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Search Results for " kdr "

Targets Recommended: VEGFR FGFR HER

57

抑制剂 & 化合物

24

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4075	Sulfatinib KDR-IN-1,索凡替尼	VEGFR; FGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Sulfatinib (KDR-IN-1) (HMPL-012) 是一种有效且高度选择性的酪氨酸激酶抑制剂，可抑制VEGFR1/2/3，FGFR1和CSF1R，IC50范围为1 到 24 nM 之间。
T10123	VEGFR-2-IN-9 KDR-in-4	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	VEGFR-2-IN-9 (KDR-in-4) 是一种高效的 KDR/VEGFR2 抑制剂（IC50：7 nM）,可用于研究乳腺癌。
T1057	Azilsartan TAK-536,阿齐沙坦	RAAS	Endocrinology/Hormones
	Azilsartan (TAK-536) 是一种高活性的血管紧张素Ⅱ1型受体特异性拮抗剂(IC50:2.6 nM)。
TQ0166	Tesevatinib KD-019,XL-647,EXEL-7647	EGFR; VEGFR; FLT; Ephrin Receptor	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tesevatinib (XL-647) 是一种口服的多靶点酪氨酸激酶抑制剂，对 EGFR、ErbB2、KDR、Flt4和 EphB4的 IC50值分别为 0.3、16、1.5、8.7和 1.4 nM。
T3113	Foretinib GSK089,EXEL-2880,GSK1363089,XL880	VEGFR; Tie-2; c-Met/HGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Foretinib (GSK1363089) 是多靶点酪氨酸激酶抑制剂，能够抑制 Met (IC50:0.4 nM) 和 KDR (IC50:0.9 nM)。
T62745	AMPK-IN-3	VEGFR; AMPK	Angiogenesis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	AMPK-IN-3 是一种新型且选择性和强效性的 AMPK 抑制剂，其对AMPK (α2)、AMPK (α1) 和 KDR 具有抑制作用， IC50 值分别为 60.7、107 和 3820 nM。AMPK-IN-3 在 K562 细胞中显示出抗癌活性。
T17219	Vatalanib free base	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Vatalanib free base 是一种 VEGFR2/KDR 的抑制剂，其IC50=37nM。
T5466	Tyrosine kinase-IN-1	VEGFR; FGFR; FLT; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Tyrosine kinase-IN-1是一种多靶点酪氨酸激酶抑制剂，能够抑制KDR (IC50:4 nM)，Flt-1 (IC50:20 nM)，FGFR1 (IC50:4 nM) 和 PDGFRα (IC50:2 nM)。
T6720	Vatalanib dihydrochloride CGP-797870 dihydrochloride,ZK-222584 dihydrochloride,Vatalanib 2HCl,PTK787 dihydrochloride,Vatalanib (PTK787) 2HCl,CGP-79787 dihydrochloride,瓦他拉尼	Apoptosis; VEGFR; PDGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Vatalanib dihydrochloride (PTK787 dihydrochloride) 是一种VEGFR2/KDR 的抑制剂，其IC50值为37nM。
T2358	ENMD-2076	Apoptosis; VEGFR; FGFR; FLT; c-RET; PDGFR; Src; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	ENMD2076是一种多靶点激酶抑制剂，抑制Aurora A、Flt3、KDR/VEGFR2、Flt4/VEGFR3、FGFR1、FGFR2、Src、PDGFRα的IC50值分别为1.86、14、58.2、15.9、92.7、70.8、20.2 and 56.4 nM。
T13238	Tyrphostin AG1433 SU1433,AG1433	VEGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Tyrphostin AG1433 (AG1433) 是选择性的PDGFRβ和VEGFR-2 (Flk-1/KDR)抑制剂，IC50分别为 5.0 μM 和 9.3 μM。Tyrphostin AG1433有防止血管形成的活性。
T13178	Toceranib 托西尼布,PHA 291639E,SU11654	VEGFR; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Toceranib (PHA 291639E) 是口服具有活力的受体酪氨酸激酶 (RTK) 抑制剂，能有效抑制PDGFR，VEGFR，Kit，抑制 PDGFRβ 和 Flk-1/KDR 的Ki 分别为 5 nM 和 6 nM。它具有抗肿瘤和抗血管生成作用，用于研究犬肥大细胞肿瘤。
T2496	(Z)-Semaxinib SU5416	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	(Z)-Semaxinib (SU5416) 是一种有效的选择性 VEGFR(Flk-1/KDR) 抑制剂 (IC50: 1.23 μM)，对 VEGFR 的选择性是 PDGFRβ 的 20 倍，对 FGFR、InsR 和 EGFR 没有抑制作用。 Semaxanib 是一种具有潜在抗肿瘤活性的喹诺酮衍生物。
T2640	Rebastinib DCC2036,DCC 2036,DCC-2036	Apoptosis; FLT; Bcr-Abl; Src	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Rebastinib (DCC-2036) 是一种口服有效的，非 ATP 竞争性的 Bcr-Abl 抑制剂，作用于 Abl1WT 和 Abl1T315I，IC50分别为 0.8 nM 和 4 nM，还抑制 LYN、SRC、HCK、FGR、FLT3、KDR 和 Tie-2，对 c-Kit 的活性低。Rebastinib 对 Angiopoietin2-Tie2通路具有抑制作用。
T7394	Toceranib Phosphate SU11654 phosphate,PHA 291639 phosphate,托西尼布磷酸盐	VEGFR; Tyrosinase; PDGFR; c-Kit	Angiogenesis; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Toceranib Phosphate (SU11654 phosphate) 是有效的、具有口服活性的酪氨酸激酶 (RTK) 受体抑制剂，能抑制PDGFR，VEGFR，Kit，抑制 PDGFRβ 和 Flk-1/KDR 的Ki 分别为 5 nM 和 6 nM。它具有抗肿瘤和抗血管生成作用，可用于研究犬肥大细胞肿瘤。
T2500	Cediranib AZD2171,NSC-732208,西地尼布	VEGFR; FLT; PDGFR; c-Kit; Autophagy	Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors
	Cediranib (AZD2171) 是一种可口服的高选择性VEGFR2抑制剂，对Flt1、KDR、Flt4、PDGFRα、PDGFRβ和c-Kit 的IC50值分别为小于1、小于3、5、5、36和 2nM。
T9052	XL092 CL-092,JUN04542	VEGFR; c-Met/HGFR; TAM Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	XL092 (JUN04542) 是一种ATP 竞争性的、口服有效的多受体酪氨酸激酶 (RTKs) 抑制剂，在细胞分析中的MET (IC50:15 nM)、VEGFR2 (IC50:1.6 nM)、AXL (IC50:3.4 nM) 和 MER (IC50:7.2 nM)。它具有抗肿瘤作用，具有用于研究激酶依赖性疾病的潜力。
T1667	Tandutinib MLN518,CT53518,NSC726292,坦度替尼	Apoptosis; FLT; CSF-1R; PDGFR; Src; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Tandutinib (CT53518) 是一种选择性 FLT3抑制剂，其 IC50为 0.22 μM。它还抑制c-Kit 和PDGFR，其IC50分别为 0.17 μM 和 0.20 μM。它可穿透血脑屏障，用于急性骨髓性白血病。
T2514	Linifanib 利尼伐尼,ABT-869,RG3635,AL-39324	Apoptosis; c-Fms; VEGFR; FLT; CSF-1R; PDGFR; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; Tyrosine Kinase/Adaptors
	Linifanib (AL-39324) 是一种高效口服的VEGFR 和PDGFR 家族多靶点抑制剂，具有显著的抗肿瘤活性。它对无关 RTKs、可溶性酪氨酸激酶或丝氨酸/苏氨酸激酶的活性要低得多。它是特异性 miR-10b 抑制剂，阻断miR-10b 的生物合成。
T1811	WH-4-023 KIN112,KIN001-112,Dual LCK/SRC inhibitor	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	WH-4-023 (Dual LCK/SRC inhibitor) 是选择性Lck 和Src 抑制剂，它们的 IC50 分别为 2 nM、6 nM，对p38α 和 KDR 作用效果稍弱。
T1754	ZM 306416 CB 676475	VEGFR; Bcr-Abl; Src	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	ZM 306416 (CB 676475) 是一种 VEGFR 的有效抑制剂，能够抑制 KDR (IC50:0.1 μM) 和 Flt (IC50:2 μM)，也是一种 EGFR 的抑制剂(IC50<10 nM)。
T1656	Vandetanib ZD6474,凡德他尼	Apoptosis; EGFR; VEGFR; Autophagy	Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Vandetanib (ZD6474) 是一种具有口服活性的VEGFR2/KDR 酪氨酸激酶抑制剂，IC50值为40 nM。它也抑制VEGFR3/FLT4和EGFR/HER1，IC50值分别为110和500 nM。
T22288	(1E)-CFI-400437 dihydrochloride CFI-400437 dihydrochloride	PLK	Cell Cycle/Checkpoint
	(1E)-CFI-400437 dihydrochloride (CFI-400437 dihydrochloride) 是一种选择性和有效的 polo 样激酶 4 (PLK4) 抑制剂，IC50为 0.6 nM。它还抑制 Aurora A、 Aurora B、 KDR 和 FLT-3，IC50分别为 0.37、0.21、0.48 和 0.18 μM，具有抗增殖活性。
T2624	OSI-930 OSI 930,噻尔非尼	Apoptosis; c-Fms; Raf; VEGFR; FLT; CSF-1R; Src; c-Kit	Angiogenesis; Apoptosis; MAPK; Tyrosine Kinase/Adaptors
	OSI-930 是 Kit，KDR 和 CSF-1R (c-Fms)的口服选择性抑制剂，IC50分别为 80 nM，9 nM 和 15 nM。它具有抗肿瘤活性，靶向肿瘤中的癌细胞增殖和血管生成。它还适度抑制 Flt-1，c-Raf 和 Lck，并且对 PDGFRα/β，Flt-3和 Abl 具有较弱的抑制活性。
T2064	Semaxinib 司马沙尼,SU5416	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Semaxinib (SU5416) 是一种选择性的 VEGFR(Flk-1/KDR) 抑制剂，其 IC50=1.23 μM。
T1797	Cabozantinib S-malate 苹果酸卡博替尼,Cabozantinib,卡博替尼苹果酸盐,XL184,Cabozantinib Malate	Apoptosis; VEGFR; c-Met/HGFR; TAM Receptor; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Cabozantinib S-malate (XL184) 是一种多受体酪氨酸激酶抑制剂，抑制VEGFR2，c-Met，Kit，Axl 和Flt3的IC50分别为0.035，1.3，4.6，7 和 11.3 nM。
T16995	TAS05567	FLT; c-RET; JAK; Syk	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR, and RET with IC50s of 10 nM, 4.8 nM, 600 nM, and 29 nM, respectively) in a panel of 192 kinases.
T78009	ATWLPPR Peptide
	ATWLPPR Peptide 是一种具有特异性 VEGFR2/KDR 七肽拮抗剂，能够结合VEGFR2(KDR/flk)，有效阻断VEGF与KDR的结合，并抑制VEGF诱导的体内血管生成。在体外，该肽特异性地抑制人内皮细胞的增殖；在体内，则能彻底消除VEGF诱导的血管形成。
T35570	Chiauranib CS2164,西奥罗尼	c-Fms; VEGFR; FLT; PDGFR; c-Kit; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	Chiauranib 是一种针对肿瘤血管生成的多靶点抑制剂，具有强大的抗癌作用。 Chiauranib 有效抑制血管生成相关激酶（VEGFR1、VEGFR2、VEGFR3、PDGFRα 和 c-Kit）、有丝分裂相关激酶 Aurora B 和慢性炎症相关激酶 CSF1R，IC50 值范围为 1-9 nM。
T61007	WHI-P180 hydrochloride
	WHI-P180 (Janex 3) 抑制RET, KDR 和EGFR 的IC50值分别为5 nM，66 nM 和4 μM。WHI-P180 是一种多种激酶抑制剂。
T11519	GW768505A free base	Others	Others
	GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2 (pIC50: 7.81 for VEGFR2) with anti-angiogenic activity.
T71819	RK-20448
	RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2. It also inhibits BLK, Csk, Fyn, and Lyn. RK-20448 is the cis isomer of A-419259
T80595	Conbercept KH902	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Conbercept (KH902) 是一种针对 VEGFRA 的融合蛋白，由 FLT1 第二个 C-LIKE 结构域与 KDR 第三和第四个 C-LIKE 结构域结合而成，并与 IGHG1 Fc 片段融合。该化合物设计用于中和 VEGF家族因子，具有重要的生物医学应用。
T64176	Vandetanib trifluoroacetate
	Vandetanib trifluoroacetate (D6474 trifluoroacetate) 是一种口服具有活力的、有效的 VEGFR2/KDR 酪氨酸激酶抑制剂，其 IC50 值为 40 nM。Vandetanib trifluoroacetate 对 VEGFR3/FLT4 和 EGFR/HER1 也表现出抑制作用，他们的 IC50 值分别为 110 nM、500 nM。
T68039	cep-5214
	CEP-5214是一种有效的、低纳摩尔的人 VEGF-R 酪氨酸激酶泛抑制剂，对 VEGF-R1/FLT-1、VEGF-R2/KDR 和VEGF-R3/FLT-4的IC50分别为16、8和4 nM，细胞活性与分离的酶活性相当。
T77108	Olinvacimab
	Olinvacimab (TTAC-0001) 是一种人抗 VEGFR2单克隆抗体。Olinvacimab 抑制 VEGF 与 KDR 结合，Kd 值为 0.23 nM。Olinvacimab 具有抗血管生成活性。Olinvacimab 可用于复发性胶质母细胞瘤和乳腺癌的研究。
T21641	Vandetanib hydrochloride
	Vandetanib hydrochloride (D6474 hydrochloride) 是一种有效的，口服的VEGFR2/KDR 酪氨酸激酶抑制剂 (IC50=40 nM)。Vandetanib hydrochloride 对于VEGFR3/FLT4(IC50=110 nM) 和EGFR/HER1(IC50=500 nM)也有抑制作用。
T68484	2-MT-63
	2-MT 63 is a novel TIE-2 kinase inhibitor that demonstrates unique and improved kinase selectivity compared to other inhibitors known to interact with TIE-2. 2-MT 63 has a good kinase selectivity profile in enzyme assays with >30-fold selectivity (typically much greater) against the tested kinases. Importantly, the profile includes selectivity against other targets of relevance for angiogenesis (KDR, PDGFR, EPHB4).
T39194	PLX647 dihydrochloride
	PLX647 dihydrochloride is a potent and selective dual inhibitor of FMS and KIT kinases, with IC50 values of 28 nM and 16 nM, respectively. At a concentration of 1 μM, PLX647 dihydrochloride demonstrates superior selectivity against a wide range of 400 kinases, except FLT3 and KDR, where IC50 values are 91 nM and 130 nM, respectively. This orally active compound holds great potential for targeted kinase inhibition.
T9684	(Z)-Orantinib
	(Z)-Orantinib ((Z)-SU6668) 是一种有效，选择性，具有口服活性和 ATP 竞争性的 Flk‐1/KDR，PDGFRβ和 FGFR1抑制剂，IC50值分别为 2.1，0.008 和 1.2 μM。(Z)-Orantinib 是有效的抗血管生成和抗肿瘤剂，可诱导已形成的肿瘤消退。
T68389	LY2457546
	LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. LY2457546 demonstrates potent activity against targets that include VEGFR2 (KDR), PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. In vivo, LY2457546 inhibited VEGF-driven autophosphorylation of lung KDR in the mouse and rat in a dose and concentration dependent manner. LY2457546 was well tolerated and exhibited efficacy in a 13762 synge...
T63573	WF-47-JS03
	WF-47-JS03 是选择性的、有效的、能够透过血脑屏障的 RET 激酶抑制剂，比对激酶插入域受体 (KDR) 的选择性高 500 多倍。WF-47-JS03 作用于转染 KIF5B-RET 的 Ba/F3 细胞 (IC50: 1.7 nM) 和转染 CCDC6-RET 的 LC-2/ad 肺癌细胞 (IC50: 5.3 nM)。
T38653	HG-7-85-01
	HG-7-85-01 is a type II ATP competitive inhibitor targeting wild-type and gatekeeper mutations forms of Bcr-Abl, PDGFRα, Kit, and Src kinases. It effectively inhibits T315I mutant Bcr-Abl kinase, as well as KDR and RET kinases with IC50 values of 3 nM, 20 nM, and 30 nM, respectively. In contrast, HG-7-85-01 exhibits weak or no inhibition towards other kinases (IC50 >2 μM). Furthermore, this compound inhibits cell proliferation through the induction of apoptosis and by impeding cell-cycle progres...
T68286	CE-245677 mesylate
	CE-245677 is a selective, orally active Tie2 kinase inhibitor identified by Pfizer previously in development for the treatment of certain cancers. CE-245,677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases with a cellular IC50 of 4.7 and 1 nM, resp., displays >100x selectivity against a number of other angiogenic receptor tyrosine kinases (e.g. KDR, PDGFR, FGFR) and gene family panels, and demonstrates good oral absorption in in vivo rat PK studies (F=80%).
T30855L	CGP77675 hydrate
	CGP77675 hydrate 是一种口服有效的Src 家族激酶抑制剂。CGP77675 hydrate 抑制肽底物的磷酸化和纯化 Src 的自磷酸化 (IC50分别为 5-20 和 40 nM)，并且还抑制 Src，EGFR，KDR，v-Abl 和 Lck，IC50分别为 0.02、0.15、1.0、0.31 和 0.29 μM。CGP77675 hydrate 可用于治疗与骨质流失相关的疾病，并具有抗肿瘤活性。
T62788	Pexidartinib hydrochloride
	Pexidartinib hydrochloride (PLX-3397 hydrochloride) 是一种有效的、选择性的、口服具有活力的、ATP-竞争性的集落刺激因子 1 (CSF1R 或 M-CSFR) (IC50: 20 nM) 和 c-Kit (IC50: 10 nM) 抑制剂。Pexidartinib hydrochloride 对 c-Kit 和 CSF1R 的选择性是对其他相关激酶的 10-100 倍，作用于 FLT3 (IC50: 160 nM)、KDR (VEGFR2) (IC50: 350 nM)、LCK (IC50: 860 nM)、FLT1 (VEGFR1) (IC50: 880 nM) 和 NTRK3 (TRKC) (IC50: 890 nM)。Pexidartinib hydrochloride 能够诱导细胞凋亡，表现出抗肿瘤作用。
T0520	Lenvatinib 仑伐替尼,E7080	VEGFR; FGFR; c-RET; PDGFR; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Lenvatinib (E7080) 是一种多靶点受体酪氨酸激酶抑制剂，抑制 VEGFR1-3、FGFR1-4、KIT、PDGFR 和 RET 等，具有口服活性。Lenvatinib 对 VEGFR2 和 VEGFR3 的抑制活性最强 (IC50=4/5.2 nM)。Lenvatinib 具有强效抗肿瘤活性。
T35525	PI3-Kinase α Inhibitor 2 PI3-Kinase α Inhibitor 2
	Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit. PI3Kα inhibitor 2 is a selective inhibitor of PI3Kα with IC50 values of 2, 16, 660, and 220 nM for the α, β, γ, and 2Cβ isoforms, respectively. It...
T37079	VEGFR2 Kinase Inhibitor II
	Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2's kinase activity (IC50 = 70 nM). It less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ; IC50 = 920 nM) and related receptor and non-receptor tyrosine kinases. V...
T2415	PP121	Apoptosis; VEGFR; Bcr-Abl; PDGFR; Src; mTOR; Hck	Angiogenesis; Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	PP121是一种多靶点激酶抑制剂，抑制 PDGFR、Hck、mTOR、VEGFR2、Src、Abl、DNK-PK 的 IC50值分别为2、8、10、12、14、18、60 nM。

化合物

Cat.No: T4075

Synonym: KDR-IN-1,索凡替尼

Target: VEGFR, FGFR, HER

Cat.No: T10123

Synonym: KDR-in-4

Target: VEGFR

Cat.No: T1057

Synonym: TAK-536,阿齐沙坦

Target: RAAS

Cat.No: TQ0166

Synonym: KD-019,XL-647,EXEL-7647

Target: EGFR, VEGFR, FLT, Ephrin Receptor

Cat.No: T3113

Synonym: GSK089,EXEL-2880,GSK1363089,XL880

Target: VEGFR, Tie-2, c-Met/HGFR

Cat.No: T62745

Target: VEGFR, AMPK

Vatalanib free base

Cat.No: T17219

Target: VEGFR

Tyrosine kinase-IN-1

Cat.No: T5466

Target: VEGFR, FGFR, FLT, PDGFR

Vatalanib dihydrochloride

Cat.No: T6720

Synonym: CGP-797870 dihydrochloride,ZK-222584 dihydrochloride,Vatalanib 2HCl,PTK787 dihydrochloride,Vatalanib (PTK787) 2HCl,CGP-79787 dihydrochloride,瓦他拉尼

Target: Apoptosis, VEGFR, PDGFR

Cat.No: T2358

Target: Apoptosis, VEGFR, FGFR, FLT, c-RET, PDGFR, Src, Aurora Kinase

Tyrphostin AG1433

Cat.No: T13238

Synonym: SU1433,AG1433

Target: VEGFR, PDGFR

Cat.No: T13178

Synonym: 托西尼布,PHA 291639E,SU11654

Target: VEGFR, PDGFR, c-Kit

Cat.No: T2496

Synonym: SU5416

Target: VEGFR

Cat.No: T2640

Synonym: DCC2036,DCC 2036,DCC-2036

Target: Apoptosis, FLT, Bcr-Abl, Src

Toceranib Phosphate

Cat.No: T7394

Synonym: SU11654 phosphate,PHA 291639 phosphate,托西尼布磷酸盐

Target: VEGFR, Tyrosinase, PDGFR, c-Kit

Cat.No: T2500

Synonym: AZD2171,NSC-732208,西地尼布

Target: VEGFR, FLT, PDGFR, c-Kit, Autophagy

Cat.No: T9052

Synonym: CL-092,JUN04542

Target: VEGFR, c-Met/HGFR, TAM Receptor

Cat.No: T1667

Synonym: MLN518,CT53518,NSC726292,坦度替尼

Target: Apoptosis, FLT, CSF-1R, PDGFR, Src, c-Kit

Cat.No: T2514

Synonym: 利尼伐尼,ABT-869,RG3635,AL-39324

Target: Apoptosis, c-Fms, VEGFR, FLT, CSF-1R, PDGFR, c-Kit, Autophagy

Cat.No: T1811

Synonym: KIN112,KIN001-112,Dual LCK/SRC inhibitor

Target: Src

Cat.No: T1754

Synonym: CB 676475

Target: VEGFR, Bcr-Abl, Src

Cat.No: T1656

Synonym: ZD6474,凡德他尼

Target: Apoptosis, EGFR, VEGFR, Autophagy

(1E)-CFI-400437 dihydrochloride

Cat.No: T22288

Synonym: CFI-400437 dihydrochloride

Target: PLK

Cat.No: T2624

Synonym: OSI 930,噻尔非尼

Target: Apoptosis, c-Fms, Raf, VEGFR, FLT, CSF-1R, Src, c-Kit

Cat.No: T2064

Synonym: 司马沙尼,SU5416

Target: VEGFR

Cabozantinib S-malate

Cat.No: T1797

Synonym: 苹果酸卡博替尼,Cabozantinib,卡博替尼苹果酸盐,XL184,Cabozantinib Malate

Target: Apoptosis, VEGFR, c-Met/HGFR, TAM Receptor, c-Kit

Cat.No: T16995

Target: FLT, c-RET, JAK, Syk

ATWLPPR Peptide

Cat.No: T78009

Cat.No: T35570

Synonym: CS2164,西奥罗尼

Target: c-Fms, VEGFR, FLT, PDGFR, c-Kit, Aurora Kinase

WHI-P180 hydrochloride

Cat.No: T61007

GW768505A free base

Cat.No: T11519

Target: Others

Cat.No: T71819

Cat.No: T80595

Synonym: KH902

Target: VEGFR

Vandetanib trifluoroacetate

Cat.No: T64176

Cat.No: T68039

Cat.No: T77108

Vandetanib hydrochloride

Cat.No: T21641

Cat.No: T68484

PLX647 dihydrochloride

Cat.No: T39194

Cat.No: T9684

Cat.No: T68389

Cat.No: T63573

Cat.No: T38653

CE-245677 mesylate

Cat.No: T68286

CGP77675 hydrate

Cat.No: T30855L

Pexidartinib hydrochloride

Cat.No: T62788

Cat.No: T0520

Synonym: 仑伐替尼,E7080

Target: VEGFR, FGFR, c-RET, PDGFR, c-Kit

PI3-Kinase α Inhibitor 2

Cat.No: T35525

Synonym: PI3-Kinase α Inhibitor 2

VEGFR2 Kinase Inhibitor II

Cat.No: T37079

Cat.No: T2415

Target: Apoptosis, VEGFR, Bcr-Abl, PDGFR, Src, mTOR, Hck

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00454	VEGFR2/KDR Protein, Human, Recombinant (His & Avi) VEGFR-21,Ly73,KRD1,VEGFR2,CD309,FLK1,VEGFR,KDR	Human	HEK293 Cells
	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis. VEGFR2/KDR Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-H...
TMPK-00645	VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His) KRD1,VEGFR2,FLK1,CD309,Ly73,VEGFR,VEGFR-21,KDR	Rhesus	HEK293 Cells
	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis. VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with ...
TMPY-02361	VEGFR2/KDR Protein, Human, Recombinant (His) VEGFR2,kinase insert domain receptor,VEGFR,FLK1,Flk-1,CD309	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.6 kDa and the accession number is P35968-1.
TMPJ-00593	VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His) KDR,Fetal liver kinase 1,VEGFR-2,Kinase insert doma...	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 110-140 KDa and the accession number is AAI31823.1.
TMPJ-00414	VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated Protein-tyrosine kinase receptor flk-1,KDR,Kinase i...	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 120-150 KDa and the accession number is P35968.
TMPY-02736	VEGFR2/KDR Protein, Mouse, Recombinant (His) sVEGFR-2,6130401C07,kinase insert domain receptor,VEGFR2,Flk...	Mouse	HEK293 Cells
	VEGFR2/KDR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.5 kDa and the accession number is P35918-1.
TMPY-02858	VEGFR2/KDR Protein, Mouse, Recombinant (hFc) VEGFR2,6130401C07,Krd-1,kinase insert domain receptor,Flk-1,...	Mouse	HEK293 Cells
	VEGFR2/KDR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110 kDa and the accession number is P35918.
TMPY-03202	VEGFR2/KDR Protein, Rat, Recombinant (hFc) kinase insert domain receptor	Rat	HEK293 Cells
	VEGFR2/KDR Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110 kDa and the accession number is Q5PQU0.
TMPY-01044	VEGFR2/KDR Protein, Human, Recombinant (hFc) Flk-1,CD309,FLK1,VEGFR2,VEGFR,kinase insert domain receptor	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 109 kDa and the accession number is P35968-1.
TMPY-02678	VEGFR2/KDR Protein, Rat, Recombinant (His) kinase insert domain receptor	Rat	HEK293 Cells
	VEGFR2/KDR Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.3 kDa and the accession number is A6HDB7.
TMPY-05382	VEGFR2/KDR Protein, Cynomolgus, Recombinant (His) kinase insert domain receptor	Cynomolgus	HEK293 Cells
	VEGFR2/KDR Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.7 kDa and the accession number is G7P5T2.
TMPY-05657	VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated VEGFR2,Flk-1,kinase insert domain receptor,VEGFR,CD309,FLK1	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.5 kDa and the accession number is P35968-1.
TMPY-04924	VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated VEGFR-2,6130401C07,Ly73,Krd-1,kinase insert domain receptor,...	Mouse	HEK293 Cells
	VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.5 kDa and the accession number is P35918-1.
TMPY-04940	VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated Flk-1,kinase insert domain receptor,VEGFR,CD309,VEGFR2,FLK1	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.6 kDa and the accession number is P35968-1.
TMPY-04530	VEGFR2/KDR Protein, Human, Recombinant (His & GST) Flk-1,VEGFR2,kinase insert domain receptor,FLK1,CD309,VEGFR	Human	Baculovirus Insect Cells
	VEGFR2/KDR Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 89.3 kDa and the accession number is P35968-1.
TMPY-05610	VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated Flk-1,VEGFR,kinase insert domain receptor,VEGFR2,FLK1,CD309	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 86.5 kDa and the accession number is P35968-1.
TMPY-04802	VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc) kinase insert domain receptor,CD309,VEGFR2,FLK1,Flk-1,VEGFR	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.4 kDa and the accession number is P35968-1.
TMPY-04796	VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His) FLK1,kinase insert domain receptor,CD309,VEGFR2,Flk-1,VEGFR	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.8 kDa and the accession number is P35968-1.
TMPY-04794	VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc) VEGFR,kinase insert domain receptor,Flk-1,VEGFR2,FLK1,CD309	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.5 kDa and the accession number is P35968-1.
TMPY-04795	VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His) kinase insert domain receptor,VEGFR2,FLK1,Flk-1,CD309,VEGFR	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.9 kDa and the accession number is P35968-1.
TMPJ-00865	VEGF121 Protein, Human, Recombinant (His) VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生长因子,Vascu...	Human	HEK293 Cells
	Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel...
TMPH-01201	DRD2 Protein, Human, Recombinant (His & Myc) Dopamine D2 receptor,D(2) dopamine receptor,DRD2	Human	E. coli
	Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5.
TMPJ-00355	Neuropilin-1 Protein, Human, Recombinant (aa 22-644, Avi & His), Biotinylated CD304,VEGF165R,NRP1,NRPNP1,BDCA4	Human	HEK293 Cells
	Neuropilin-1 (Npn-1, previously neuropilin; also CD304) is a 130 - 140 kDa type I transmembrane (TM) glycoprotein that regulates axon guidance and angiogenesis. Two homologues, Neuropilin-1 and Neuropilin-2, are identified. Neuropilin-1 binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis. The soluble isoform 2 binds ...
TMPJ-00870	NCK1 Protein, Human, Recombinant (His) SH2/SH3 Adaptor Protein NCK-α,SH2/SH3 Adaptor Protein NCK-Al...	Human	E. coli
	Cytoplasmic Protein NCK1 (NCK1) is a cytoplasmic protein that contains one SH2 domain and three SH3 domains. NCK1 is a member of the adapter family, which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. NCK1 maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. NCK1 plays a role in the DNA damage response, but not in the detection of the damage by ATM/ATR. It is also involved in transducing...

重组蛋白

VEGFR2/KDR Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00454

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Rhesus macaque, Recombinant (His)

Cat.No: TMPK-00645

Species: Rhesus

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (His)

Cat.No: TMPY-02361

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His)

Cat.No: TMPJ-00593

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (aa 20-764, His & Avi), Biotinylated

Cat.No: TMPJ-00414

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02736

Species: Mouse

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02858

Species: Mouse

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03202

Species: Rat

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01044

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Rat, Recombinant (His)

Cat.No: TMPY-02678

Species: Rat

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-05382

Species: Cynomolgus

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05657

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-04924

Species: Mouse

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (His), Biotinylated

Cat.No: TMPY-04940

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04530

Species: Human

Expression System: Baculovirus Insect Cells

VEGFR2/KDR Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05610

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, hFc)

Cat.No: TMPY-04802

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (Domain 2&3, His)

Cat.No: TMPY-04796

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, hFc)

Cat.No: TMPY-04794

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (Domain 1&2&3, His)

Cat.No: TMPY-04795

Species: Human

Expression System: HEK293 Cells

VEGF121 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00865

Species: Human

Expression System: HEK293 Cells

DRD2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01201

Species: Human

Expression System: E. coli

Neuropilin-1 Protein, Human, Recombinant (aa 22-644, Avi & His), Biotinylated

Cat.No: TMPJ-00355

Species: Human

Expression System: HEK293 Cells

NCK1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00870

Species: Human

Expression System: E. coli

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