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77

抑制剂 & 化合物

18

天然产物

1

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Cat. No.	Product Name	Target	Signaling Pathways
T9318	TP0586532	Others	Others
	TP0586532 是有效的non-hydroxamate LpxC 抑制剂 (IC50=0.101 μM)。TP0586532具有低心血管风险的特点，对肺炎克雷伯菌有效，包括耐药菌株。
T4570	Pipobroman Vercyte,A-8103,Amedel,哌泊溴烷	Others; DNA Alkylator/Crosslinker	DNA Damage/DNA Repair; Others
	Pipobroman (Vercyte) 是一种烷基化剂，是哌嗪的溴化衍生物。它通过抑制 DNA 和 RNA 聚合酶或减少嘧啶核苷酸掺入 DNA 发挥其作用。它在真性红细胞增多症和原发性血小板增多症中具有良好的临床活性，可用于癌症研究。
T32160	Indolidan LY 195115
	Indolidan (LY 195115) 诱导费舍尔344大鼠的心血管和肾上腺增生性病变。 Indolidan 可增加心血管疾病的风险。
T1267	Abacavir Epzicom,Ziagen,阿巴卡韦,Abacavir sulfate	Apoptosis; HIV Protease; Reverse Transcriptase	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Abacavir (Ziagen) 是一种核苷类似物逆转录酶抑制剂。
T16479	PF-04937319	Others; Glucokinase	Metabolism; Others
	PF-04937319 是一种葡萄糖激酶激活剂 (EC50 =154.4 μM)。 PF-04937319 保持降糖功效，同时降低许多其他 GKA 观察到的低血糖风险。 PF-04937319可用于治疗2型糖尿病的研究。
T21334	Bucillamine DE-019,Thiobutarit,Tiobutarit,布西拉明,SA96,DE 019,DE019	VEGFR; Antioxidant	Angiogenesis; oxidation-reduction; Tyrosine Kinase/Adaptors
	Bucillamine (DE019) 可防止高危器官移植中的缺血/再灌注损伤，抑制 VEGF 的产生。 Bucillamine 是一种具有抗风湿和抗血管生成特性的口服活性巯基供体和抗氧化剂。 Bucillamine 可用于脉络膜新生血管和类风湿性关节炎的研究。
T1595	Nevirapine NSC 641530,奈韦拉平,BI-RG 587,奈伟拉平,NVP	HIV Protease; Reverse Transcriptase	Microbiology/Virology; Proteases/Proteasome
	Nevirapine (NVP) 是一种 HIV-1逆转录酶非核苷抑制剂，Ki 值为 270 μM，可用于研究 HIV/AIDS。
T15549	Icosabutate NST-4016,PRC-4016	Others	Others
	Icosabutate (NST-4016) 是一种具有口服活性的二十碳五烯酸的衍生物，可抑制 NASH 的肝脏炎症和纤维化，可改善他汀类药物治疗的残留高甘油三酯血症患者的心血管风险状况，降低甘油三脂，可用于研究肝纤维化和动脉粥样硬化。
T6295	Dabigatran BIBR 953,BIBR 953ZW,达比加群	Thrombin	Proteases/Proteasome
	Dabigatran (BIBR 953ZW) 是一种口服抗凝剂，是一种可逆的，竞争性的直接凝血酶 (thrombin) 抑制剂，Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。
T21013	Clomipramine Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina,氯米帕明	5-HT Receptor	GPCR/G Protein; Neuroscience
	Clomipramine (Clomicalm) 是一种三环类抗抑郁药，能够有效阻断 5-HT 再摄取 (IC50:1.5 nM) ，可用于研究强迫症 (OCD) 及抑郁症。
TP1676L	C-Reactive Protein (CRP) 201-206 acetate C-Reactive Protein (CRP) 201-206 acetate(130348-99-1 free base)	Others	Others
	C-Reactive Protein (CRP) 201-206 acetate (C-Reactive Protein )(130348-99-1 free base) 是 C-反应蛋白的 201-206 片段。 C-反应蛋白 (CRP) 醋酸盐是炎症的原型标志物，是心血管风险标志物，可能促进动脉粥样硬化形成。
T6381	Amifostine trihydrate Ethyol trihydrate,WR2721,三水氨磷汀,Amifostine	Others; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Others
	Amifostine trihydrate (WR2721) 是一种广谱细胞保护剂和辐射防护剂。它可选择性保护正常组织免受放射线和化学疗法造成的损害。它是有效的HIF-α1和p53诱导剂。它通过清除氧衍生的自由基来保护细胞免受损伤。它可降低肾脏毒性并具有抗血管生成作用。
T2534	Pitavastatin calcium P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,匹伐他汀钙,NK-104	Apoptosis; Mitophagy; Endogenous Metabolite; HMG-CoA Reductase; Autophagy	Apoptosis; Autophagy; Metabolism
	Pitavastatin calcium (NK-104) 是一种羟甲基戊二酰-CoA 还原酶抑制剂。它在 HepG2 细胞中抑制乙酸合成胆固醇的IC50为 5.8 nM。它是高效的肝细胞低密度脂蛋白胆固醇受体诱导剂。具有抗癌活性。
T3655	BMS-1 PD1-PDL1 inhibitor 1,PD-1/PD-L1 inhibitor 1	Apoptosis; PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-1 (PD-1/PD-L1 inhibitor 1)是一种 PD-1/PD-L1蛋白质/蛋白质相互作用的抑制剂，IC50为 6 到 100 nM。
T0056	Oxeladin citrate	Others	Others
	Oxeladin citrate 是止咳剂，能够对各种病因引发咳嗽进行有效研究。
T16558	Polidocanol Polyoxyethylene lauryl ether,Polyoxyethyleneglycol Dodecyl Ether	Others	Others
	Polidocanol (Polyoxyethylene lauryl ether) 是月桂醇的烷基聚乙二醇醚，是天然矿物油中天然脂肪醇或烷基醇的衍生物，是一种硬化剂。Polidocanol 可用做局部麻醉，但与其他麻醉药物合用时有增强麻醉药物对心血管系统作用的风险。
T19722	Benazeprilat CGS14831,CGS-14831,CGS 14831	RAAS; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Benazeprilat(CGS 14831) 是一种具有口服活性的贝那普利活性代谢物。Benazeprilat 具有高效的抗血压活性，可与其他其他类别的化合物（包括噻嗪类利尿剂和钙通道阻滞剂）联合使用来减少与心血管风险和继发性终末器官损伤相关的疾病的发生。Benazeprilat 可能用于研究急性左心室衰竭。
T31206	Darexaban YM 150,Darexaban, Tanexaban,YM150	Factor Xa	Metabolism
	Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂，IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。
TP1516L	C-Reactive Protein (CRP) 77-82 acetate C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base)	Others	Others
	C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base) 是 C-反应蛋白的 77-82 片段。 C-反应蛋白 (CRP) 是炎症的原型标志物，是心血管风险标志物，可能促进动脉粥样硬化。C-反应蛋白 (CRP) 是一种环状（环状）五聚体蛋白，存在于血浆中，其循环浓度炎症反应而升高。它是一种肝脏来源的急性期蛋白，在巨噬细胞和 T 细胞分泌 IL-6 后会增加。
T71941	Lig3	Others	Others
	Lig3 is an inhibitor against high-risk strains of human papillomavirus (HPV) E6 oncoprotein.
T16067	Metrizoic acid 甲泛影酸,Metrizoate	Others	Others
	Metrizoic acid is an ionic contrast medium. Metrizoic acid displays high osmolality and has a risk of inducing allergic reactions.
T70349	DJT06001	Others	Others
	DJT06001 is a selective Factor Xa inhibitor, reducing thrombus formation with low risk of bleeding.
T32782	Lipopeptin A	Others	Others
	Lipopeptin A is a lipoprotein subclass that is a risk factor for atherosclerotic diseases such as coronary heart disease and stroke.
T26289	TRC210258 TRC-210258,TRC 210258
	TRC210258 is a TGR5 agonist that acts by decreasing glycemic and dyslipidemic cardiovascular risk in animal models of diabesity.
T29216	Zimelidine A23140,A 23140,A-23140
	Zimelidine is a serotonin uptake inhibitor formerly used for depression, but was withdrawn worldwide because of the risk of Gullain-Barre syndrome associated with its use.
T13728	Hydrocortisone buteprate HBP,Hydrocortisone probutate	Others	Others
	Hydrocortisone buteprate (Hydrocortisone probutate) is a medium potent, non-halogenated double-ester of hydrocortisone with a favorable benefit/risk ratio for the treatment of inflammatory skin disorders.
T69516	Thenalidine tartrate	Others	Others
	Thenalidine is an antihistamine with anticholinergic properties used as an antipruritic drug. It was withdrawn from the US, Canadian, and UK markets due to a risk of neutropenia. Thenalidine is an antagonist of the H1-receptor.
T68437	Febuxostat 67M-1	Others	Others
	Febuxostat 67M-1 is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and reduces the risk of gout or kidney stone formation.
T15755	Lidoflazine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Lidoflazine is a high-affinity blocker of the HERG K+ channel and is an antianginal calcium channel blocker. It carries an obvious risk of QT interval prolongation and ventricular arrhythmia.
T17100	Tin(IV) mesoporphyrin IX dichloride Stannsoporfin	Others	Others
	Tin(IV) mesoporphyrin IX dichloride is a heme oxygenase inhibitor being developed for the prevention of hyperbilirubinemia in infants at risk of developing jaundice.
T40245	Miroestrol
	Miroestrol is a potent phytoestrogen compound with multifaceted biological effects. It induces a mammogenic effect and demonstrates neuroprotective properties, along with the ability to prevent bone loss in ovariectomized mice. Additionally, Miroestrol has been shown to reduce the risk of cancer [4].
T69002	Zimeldine hydrochloride hydrate
	Zimeldine hydrochloride hydrate is a serotonin uptake inhibitor that was formerly used for depression but was withdrawn worldwide in September 1983 because of the risk of Guillain-Barre Syndrome associated with its use.
T68505	Obicetrapib sodium
	Obicetrapib sodium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
T68503	Obicetrapib potassium
	Obicetrapib potassium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
T71358	Nialamide monohydrochloride
	Nialamide monohydrochloride is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was used as an antidepressant. It was withdrawn by Pfizer several decades ago due to the risk of hepatotoxicity.
T26605	Alyssin
	Alyssin is a sulforaphane homolog and antioxidant. It induces phase II enzymes and increases Nrf2 levels in adenocarcinoma cells. It decreases the metabolism of polycyclic aromatic hydrocarbons, supressing the risk of carcinogenesis in vitro.
T69281	Febuxostat 67M-4	Others	Others
	Febuxostat 67M-4 is a derivative compound of Febuxostat 67M-1 which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and reduces the risk of gout or kidney stone formation.
T16377	Odiparcil SB-424323	Thrombin	Proteases/Proteasome
	Odiparcil is an orally active beta-d-thioxyloside analog. Odiparcil is an indirect thrombin inhibitor that exerts its anticoagulant effect through activation of antithrombin II (heparin cofactor II). It also has an antithrombotic activity associated with a reduced risk of adverse bleeding events.
T20419	Raloxifene Pharoxifene,雷洛昔芬,Raloxifenum,Keoxifene,LY-139481	Estrogen Receptor/ERR; Others	Endocrinology/Hormones; Others
	Raloxifene (LY-139481) 是一种苯并噻吩类化合物，是一种选择性雌激素受体 (estrogen receptor) 调节剂 (SERM)，对骨、血脂有雌激素激动作用，对乳腺和子宫有雌激素拮抗作用。它用于乳腺癌和骨质疏松症研究。
T68504	Obicetrapib calcium
	Obicetrapib calcium is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
TP1028	Calcitonin, eel Thyrocalcitonin eel
	Calcitonin, eel is a peptide hormone that plays a crucial role in maintaining calcium balance within the body. It is extensively utilized in the scientific investigation of postmenopausal osteoporosis, a condition characterized by decreased bone density and an increased risk of fractures in women after menopause.
T71865	DSM43	Others	Others
	DSM43 is a dihydroorotate dehydrogenase (DHODH) inhibitor. Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target for malaria treatmen
T69282	Febuxostat 67M-2
	Febuxostat 67M-2 is a derivative compound of Febuxostat 67M-1 which is an inhibitor of xanthine oxidase. It reduces uric acid production in the body and also used to reduce the risk of gout or kidney stone formation.
T27025	Cizolirtine citrate E-4018,E4018,E 4018
	Cizolirtine is a calcitonin gene-related peptide antagonist. Cizolirtine may be useful for alleviating some neuropathic somatosensory disorders, in particular cold allodynia, with a reduced risk of undesirable side effects. Cizolirtine inhibits the spinal
T71980	Omeprazole acid
	Omeprazole acid is a medication used in the treatment of gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. Omeprazole is a proton pump inhibitor and as such blocks the release of stomach acid.
T62610	LY3154885	Others	Others
	LY3154885 是一种口服具有活力的多巴胺 D1 受体正变构调节剂 (PAM)。LY3154885 对药物-药物相互作用 (DDI) 的风险具有改善作用。
T79212	mTOR inhibitor-12	mTOR	PI3K/Akt/mTOR signaling
	mTORinhibitor-12（Compound 11）为选择性脑渗透性mTOR抑制剂，无遗传毒性风险，适用于中枢神经系统疾病研究。
T63025	Antitubercular agent-26
	Antitubercular agent-26 (Compound 32) 是一种口服具有活力的抗结核剂，能够作用于 M. tuberculosisH37Rv 细胞（在细胞外的 IC50: 0.50 μM，细胞内的 IC50: 0.51 μM)。Antitubercular agent-26 具有良好的代谢稳定性，及低心脏毒性风险低，没有遗传毒性。
TP1676	C-Reactive Protein (CRP) (201-206) C-Reactive Protein (CRP) 201-206	Others	Others
	C-Reactive Protein (CRP) (201-206) 是 C-反应蛋白的 201-206 片段。其中C-反应蛋白 (CRP) 是炎症的原型标志物，是心血管风险标志物，可能促进动脉粥样硬化形成。
T76752	Motavizumab
	Motavizumab (MEDI-524)为针对humanRSV(呼吸道合胞病毒)的单克隆抗体。该化合物主要应用于对高危婴儿的呼吸道合胞病毒感染的研究。

化合物

Cat.No: T9318

Target: Others

Cat.No: T4570

Synonym: Vercyte,A-8103,Amedel,哌泊溴烷

Target: Others, DNA Alkylator/Crosslinker

Cat.No: T32160

Synonym: LY 195115

Cat.No: T1267

Synonym: Epzicom,Ziagen,阿巴卡韦,Abacavir sulfate

Target: Apoptosis, HIV Protease, Reverse Transcriptase

Cat.No: T16479

Target: Others, Glucokinase

Cat.No: T21334

Synonym: DE-019,Thiobutarit,Tiobutarit,布西拉明,SA96,DE 019,DE019

Target: VEGFR, Antioxidant

Cat.No: T1595

Synonym: NSC 641530,奈韦拉平,BI-RG 587,奈伟拉平,NVP

Target: HIV Protease, Reverse Transcriptase

Cat.No: T15549

Synonym: NST-4016,PRC-4016

Target: Others

Cat.No: T6295

Synonym: BIBR 953,BIBR 953ZW,达比加群

Target: Thrombin

Cat.No: T21013

Synonym: Chlorimipramine,Anafranil,Clomicalm,Anafranil (free base),Clomipramina,氯米帕明

Target: 5-HT Receptor

C-Reactive Protein (CRP) 201-206 acetate

Cat.No: TP1676L

Synonym: C-Reactive Protein (CRP) 201-206 acetate(130348-99-1 free base)

Target: Others

Amifostine trihydrate

Cat.No: T6381

Synonym: Ethyol trihydrate,WR2721,三水氨磷汀,Amifostine

Target: Others, HIF/HIF Prolyl-Hydroxylase

Pitavastatin calcium

Cat.No: T2534

Synonym: P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,匹伐他汀钙,NK-104

Target: Apoptosis, Mitophagy, Endogenous Metabolite, HMG-CoA Reductase, Autophagy

Cat.No: T3655

Synonym: PD1-PDL1 inhibitor 1,PD-1/PD-L1 inhibitor 1

Target: Apoptosis, PD-1/PD-L1

Oxeladin citrate

Cat.No: T0056

Target: Others

Cat.No: T16558

Synonym: Polyoxyethylene lauryl ether,Polyoxyethyleneglycol Dodecyl Ether

Target: Others

Cat.No: T19722

Synonym: CGS14831,CGS-14831,CGS 14831

Target: RAAS, Endogenous Metabolite

Cat.No: T31206

Synonym: YM 150,Darexaban, Tanexaban,YM150

Target: Factor Xa

C-Reactive Protein (CRP) 77-82 acetate

Cat.No: TP1516L

Synonym: C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base)

Target: Others

Cat.No: T71941

Target: Others

Cat.No: T16067

Synonym: 甲泛影酸,Metrizoate

Target: Others

Cat.No: T70349

Target: Others

Cat.No: T32782

Target: Others

Cat.No: T26289

Synonym: TRC-210258,TRC 210258

Cat.No: T29216

Synonym: A23140,A 23140,A-23140

Hydrocortisone buteprate

Cat.No: T13728

Synonym: HBP,Hydrocortisone probutate

Target: Others

Thenalidine tartrate

Cat.No: T69516

Target: Others

Febuxostat 67M-1

Cat.No: T68437

Target: Others

Cat.No: T15755

Target: Calcium Channel

Tin(IV) mesoporphyrin IX dichloride

Cat.No: T17100

Synonym: Stannsoporfin

Target: Others

Cat.No: T40245

Zimeldine hydrochloride hydrate

Cat.No: T69002

Obicetrapib sodium

Cat.No: T68505

Obicetrapib potassium

Cat.No: T68503

Nialamide monohydrochloride

Cat.No: T71358

Cat.No: T26605

Febuxostat 67M-4

Cat.No: T69281

Target: Others

Cat.No: T16377

Synonym: SB-424323

Target: Thrombin

Cat.No: T20419

Synonym: Pharoxifene,雷洛昔芬,Raloxifenum,Keoxifene,LY-139481

Target: Estrogen Receptor/ERR, Others

Obicetrapib calcium

Cat.No: T68504

Calcitonin, eel

Cat.No: TP1028

Synonym: Thyrocalcitonin eel

Cat.No: T71865

Target: Others

Febuxostat 67M-2

Cat.No: T69282

Cizolirtine citrate

Cat.No: T27025

Synonym: E-4018,E4018,E 4018

Omeprazole acid

Cat.No: T71980

Cat.No: T62610

Target: Others

mTOR inhibitor-12

Cat.No: T79212

Target: mTOR

Antitubercular agent-26

Cat.No: T63025

C-Reactive Protein (CRP) (201-206)

Cat.No: TP1676

Synonym: C-Reactive Protein (CRP) 201-206

Target: Others

Cat.No: T76752

Cat. No.	Product Name	Target	Signaling Pathways
T8301	Amaranth Acid Red 27,酸性红 27	Others	Others
	Amaranth (Acid Red 27) 是一种阴离子染料, 可应用到天然和合成纤维、皮革、纸张及苯酚-甲醛树脂。它是一种暗红色至紫色的偶氮染料，可用作食品染料和化妆品。
T19608	Zinc sulfate heptahydrate	Others	Others
	Zinc sulfate heptahydrate 是七水合形式的硫酸锌，是一种膳食补充剂，可用于锌缺乏症和预防高危人群的锌缺乏症。
T8343	8-Hydroxy-2'-deoxyguanosine 8-OHdG,8-Hydroxydeoxyguanosine,8-Hydroxy-2-Deoxyguanosine,2'-Deoxy-8-oxoguanosine,8 OHdG,8-Oxo-dG,8-OH-脱氧鸟嘌呤,8 Oxo dG,8-Oxo-2'-deoxyguanosine	Endogenous Metabolite	Metabolism
	8-Hydroxy-2'-deoxyguanosine (8-OHdG) 是致癌反应和氧化应激的关键生物标志物。
T4863	DL-Homocysteine DL-高半胱氨酸,2-Amino-4-mercaptobutyric acid	Endogenous Metabolite	Metabolism
	DL-Homocysteine (2-Amino-4-mercaptobutyric acid) 是弱神经毒素，能够影响犬尿酸的产生。
T2S1749	Protogracillin 原纤细薯蓣皂甙	Others	Others
	Protogracillin 是一种甾体皂苷，分离自Dioscorea zingiberensisWright (DZW) 中。从 DZW 根状茎中获得的甾体皂苷具有抗血栓作用，同时由降低心血管疾病风险的潜力。
T5112	DI-N-OCTYL PHTHALATE	Others	Others
	DI-N-OCTYL PHTHALATE 用作增塑剂和添加剂。用于毒理学研究以及通过邻苯二甲酸盐从食品接触材料 (FCM) 迁移到食品中而发生的食品污染风险评估研究。
S00015	Tea polyphenol	Apoptosis; Others; Autophagy	Apoptosis; Autophagy; Others
	Tea polyphenol 也称为绿茶提取物，是茶中天然存在的酚类化合物，具有抗癌、抗氧化、抑制细胞增殖、诱导细胞凋亡、延缓细胞周期和调节致癌物代谢等生物活性。
TN5131	Tetrahydrocannabivarin THCV,delta9-Tetrahydrocannabivarin,CRM,Tetrahydrocannavarin	Cannabinoid Receptor	GPCR/G Protein
	Tetrahydrocannabivarin (CRM) 是 cannabinoid type 1 receptor 的中性拮抗剂，对 2 型糖尿病有潜在治疗价值。
T3011	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine,犬尿氨酸	Others; Endogenous Metabolite	Metabolism; Others
	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是一种酮类和氨基酸衍生物，具有多种生物功能，包括血管舒张、免疫调节和神经调节活性。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是烟酸的前体。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 的异常产生与神经系统疾病相关的认知缺陷和抑郁症状有关。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 在某些类型的癌细胞中过度表达，可能被用作评估癌症风险的生物标志物。
T7031	Aristolochic acid B 马兜铃酸B,Aristolochic Acid II,马兜铃酸 B	DNA	DNA Damage/DNA Repair
	Aristolochic acid B (Aristolochic Acid II) 是一种来自马兜铃科分类群的天然产物，是马兜铃酸的主要成分之一。已知马兜铃酸是诱变剂和致癌物质。它在体内表现出比 Aristolochic acid I 更大的致癌风险。
T4944	Nervonic acid cis-15-Tetracosenoic acid,神经酸,Selacholeic acid	Endogenous Metabolite	Metabolism
	Nervonic acid (Selacholeic acid) 是在髓磷脂生物合成中很重要的单不饱和脂肪酸。
T3123	Allicin	ERK; IL Receptor; Others; IκB/IKK; p38 MAPK; TNF; ROS; Caspase; Antifection	Apoptosis; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; Others; Proteases/Proteasome
	Allicin 具有抗氧化、杀菌、抗癌、抗炎活性，对肠上皮细胞具有抑制性免疫调节作用。 Allicin 能显着抑制胰岛素诱导的血管平滑肌细胞的增殖和迁移，这可能与抑制 ERK 信号通路的激活有关。 Allicin 有利于降低高胆固醇血症大鼠的血液胆固醇、甘油三酯水平和收缩压，它可能有益于影响动脉粥样硬化的两个危险因素——高脂血症和高血压。
T4919	Ureidopropionic acid Carbamoyl-b-alanine,3-酰脲丙酸,3-Ureidopropionic acid	Endogenous Metabolite	Metabolism
	Ureidopropionic acid (3-Ureidopropionic acid) 是尿嘧啶代谢的中间体。更具体地说，它是二氢尿嘧啶的分解产物，由二氢嘧啶酶产生。它通过β -脲丙酸酶进一步分解为β -丙氨酸。尿素丙酸本质上是β -丙氨酸的尿素衍生物。高水平的尿丙酸存在于β -尿丙酸酶(UP)缺乏的个体中。嘧啶代谢中的酶缺乏与抗肿瘤药物5-氟尿嘧啶的严重毒性风险有关。
T4877	L-Homocystine	Endogenous Metabolite	Metabolism
	L-Homocystine 是一种 L-homocysteine 的氧化物。其中 L-homocysteine 是抗血栓因子、血管舒张损害剂、促炎因子，也是研究心血管疾病发生机制的内质网应激反应的诱导剂。
T0256	Citric acid trilithium salt tetrahydrate Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate	Dehydrogenase; GSK-3; HIF/HIF Prolyl-Hydroxylase; Antibacterial; GluR	Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells
	Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是一种用于治疗精神疾病的药物。它也是一种医药和建筑材料, 可用于氨基酸定量分析时的梯度洗脱。
T3S0209	Vincristine	ERK; p38 MAPK; NF-κB; Akt; JNK; mTOR	Cytoskeletal Signaling; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Vincristine 属于生物碱类天然产物，可与微管蛋白结合并抑制微管的形成，从而抑制肿瘤细胞的有丝分裂。Vincristine 可用作微管去稳定剂，用于研究治疗血液系统肿瘤，如白血病和淋巴瘤以及儿童肉瘤的相关研究。
TN1919	(+)-Medioresinol 梣皮树脂醇,皮树脂醇,Medioresinol	Beta Amyloid; ROS; Antifection	Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in the amount of α²-secretase, it is a potentially valuable antiamyloidogenic agent for the prevent
T82031	Isoguaiacin
	Isoguaiacin为一种天然产物，具有复杂的多环化合物结构，广泛应用于生物医药研究领域。

天然产物

Cat.No: T8301

Synonym: Acid Red 27,酸性红 27

Target: Others

Zinc sulfate heptahydrate

Cat.No: T19608

Target: Others

8-Hydroxy-2'-deoxyguanosine

Cat.No: T8343

Synonym: 8-OHdG,8-Hydroxydeoxyguanosine,8-Hydroxy-2-Deoxyguanosine,2'-Deoxy-8-oxoguanosine,8 OHdG,8-Oxo-dG,8-OH-脱氧鸟嘌呤,8 Oxo dG,8-Oxo-2'-deoxyguanosine

Target: Endogenous Metabolite

DL-Homocysteine

Cat.No: T4863

Synonym: DL-高半胱氨酸,2-Amino-4-mercaptobutyric acid

Target: Endogenous Metabolite

Cat.No: T2S1749

Synonym: 原纤细薯蓣皂甙

Target: Others

DI-N-OCTYL PHTHALATE

Cat.No: T5112

Target: Others

Cat.No: S00015

Target: Apoptosis, Others, Autophagy

Tetrahydrocannabivarin

Cat.No: TN5131

Synonym: THCV,delta9-Tetrahydrocannabivarin,CRM,Tetrahydrocannavarin

Target: Cannabinoid Receptor

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

Cat.No: T3011

Synonym: Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine,犬尿氨酸

Target: Others, Endogenous Metabolite

Aristolochic acid B

Cat.No: T7031

Synonym: 马兜铃酸B,Aristolochic Acid II,马兜铃酸 B

Target: DNA

Cat.No: T4944

Synonym: cis-15-Tetracosenoic acid,神经酸,Selacholeic acid

Target: Endogenous Metabolite

Cat.No: T3123

Target: ERK, IL Receptor, Others, IκB/IKK, p38 MAPK, TNF, ROS, Caspase, Antifection

Ureidopropionic acid

Cat.No: T4919

Synonym: Carbamoyl-b-alanine,3-酰脲丙酸,3-Ureidopropionic acid

Target: Endogenous Metabolite

Cat.No: T4877

Target: Endogenous Metabolite

Citric acid trilithium salt tetrahydrate

Cat.No: T0256

Synonym: Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate

Target: Dehydrogenase, GSK-3, HIF/HIF Prolyl-Hydroxylase, Antibacterial, GluR

Cat.No: T3S0209

Target: ERK, p38 MAPK, NF-κB, Akt, JNK, mTOR

(+)-Medioresinol

Cat.No: TN1919

Synonym: 梣皮树脂醇,皮树脂醇,Medioresinol

Target: Beta Amyloid, ROS, Antifection

Cat.No: T82031

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0173	Dabigatran-d4 HCl
	Dabigatran-d4 HCl 是 Dabigatran HCl 的氘代化合物。Dabigatran HCl 的 CAS 号为 211914-51-1。Dabigatran 是一种口服抗凝剂，是一种可逆的，竞争性的直接凝血酶 (thrombin) 抑制剂，Ki=4.5 nM。它也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。

同位素

Dabigatran-d4 HCl

Cat.No: TMIH-0173

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