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Search Results for " pro-apoptotic "

50

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21919	UCF 101	Apoptosis	Apoptosis
	UCF 101 是竞争性的促凋亡蛋白酶Omi/HtrA2选择性抑制剂。它对 MI/R 损伤具有明显的心脏保护作用，还具有一定的神经保护作用。它在 543 nm 处具有天然的红色荧光，可用于监视其进入哺乳动物细胞的能力。
T23861	CAY10526 CAY-10526,BTH,CAY 10526	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	CAY10526 (BTH) 是 mPGES-1 的选择性抑制剂，可抑制 NF-κB 信号通路。
T12870	SCH79797 dihydrochloride	Apoptosis; Others; Protease-activated Receptor	Apoptosis; GPCR/G Protein; Others
	SCH79797 dihydrochloride 是一种有效的特异性蛋白酶激活受体 1 (PAR1) 拮抗剂，IC50 为 70 nM，Ki 为 35 nM。SCH79797 dihydrochloride 具有抗增殖和促凋亡作用。
T76371	Tumor targeted pro-apoptotic peptide
	Tumor targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2) 为抗肿瘤肽，具有破坏线粒体膜和促进细胞凋亡功能，展现小鼠的抗癌活性。
T13689	Ethylene dimethanesulfonate	Apoptosis	Apoptosis
	Ethylene dimethanesulfonate 是温和的烷基化乙二醇非挥发性甲烷磺酸二酯，对 LC 具有选择性的促凋亡作用。
T77662	DJ4	Apoptosis	Apoptosis
	DJ4 在微摩尔范围内以剂量依赖性诱导促凋亡作用。
T4212	XMU-MP-1	Hippo pathway	Stem Cells
	XMU-MP-1 是一种促凋亡、无菌的 20 样激酶 MST1 和 2 的抑制剂。
T12644L	(S)-Thalidomide (S)-(-)-Thalidomide	Apoptosis	Apoptosis
	(S)-Thalidomide ((S)-(-)-Thalidomide) 是 Thalidomide 的 S 型异构体，具有免疫调节，抗炎，抗癌，抗血管生成活性和促凋亡活性，可用于研究麻风结节性红斑和骨髓瘤。
T77571	Bcl-B inhibitor 1	Apoptosis; BCL	Apoptosis
	Bcl-B inhibitor 1 是一种Bcl-B 抑制剂，具有抗肿瘤活性，通过与BH3结构域促凋亡蛋白结合并失活。
T9726	2’-OMe-Guanosine	Apoptosis; Nucleoside Antimetabolite/Analog	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	2'-O-Methylguanosine 是一种修饰核苷，是tRNA 上的核苷在 tRNA 鸟苷-2’-o-甲基转移酶作用下产生的。2'-O-Methylguanosine 具有一定的促凋亡作用。
T77332	TV 3279	BCL; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling
	TV 3279是一种新型ChE-MAI 抑制剂，神经保护特性取决于它们诱导抗凋亡蛋白PKC、Bcl-2、Bcl-x 和SOD 的能力，并阻止促凋亡酶甘油醛磷酸脱氢酶在PC-12和神经母细胞瘤细胞中的核易位。
T70388	(S)-Enitociclib VIP152	CDK	Cell Cycle/Checkpoint
	(S)-Enitociclib (VIP152) 是一种选择性 CDK9 抑制剂，通过抑制 RNA 聚合酶 II 介导的转录来诱导 MYC+ 淋巴瘤的完全消退，抑制抗凋亡和促生存蛋白的转录。
T31020	CP 461 OSI 461,UNII-68OJX9I7DT,CP-461,CP461	Apoptosis; PDE	Apoptosis; Metabolism
	CP 461 (UNII-68OJX9I7DT) 是一种特异性 PDE2A 抑制剂，是一种新型促凋亡化合物，能抑制环 GMP 磷酸二酯酶，但不能抑制环氧化酶-1 或-2。CP 461 在体外可抑制多种人类肿瘤细胞系的生长，并选择性地诱导癌细胞系而不是正常细胞凋亡。
T10827	CK2/ERK8-IN-1 TMCB	Apoptosis; ERK; Casein Kinase; Pim; DYRK	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors
	CK2/ERK8-IN-1 (TMCB) 是一种酪蛋白激酶 2 (CK2) (Ki 为 0.25 µM) 和 ERK8 (MAPK15, ERK7) 的双重抑制剂，IC50 均为 0.50 μM。CK2/ERK8-IN-1 也与 PIM1，HIPK2 和 DYRK1A 结合，Ki 值分别为 8.65 µM，15.25 µM 和 11.9 µM。
T10706	CCI-006	Mitochondrial Metabolism	Metabolism
	CCI-006 是一种 MLL 重排白血病细胞的选择性抑制剂和化学增敏剂。它能够抑制线粒体呼吸，造成 MLL-r 白血病细胞亚群中无法克服的线粒体去极化和促凋亡未折叠蛋白反应。
T2129	Zaprinast	PDE	Metabolism
	Zaprinast 是一种 cGMP 选择性的磷酸二酯酶(PDE)抑制剂，是一种 GPR35激动剂，对大鼠 GPR35 有很强的激活作用，对人 GPR35 有一定的激活作用。它通过抗增殖和促凋亡作用，减少血管的重构。
T6778	BDA-366	BCL	Apoptosis
	BDA-366 是一种有效的 Bcl2 拮抗剂，以高亲和力和选择性 (Ki = 3.3 nM) 结合 Bcl2-BH4 结构域。 BDA-366 诱导 Bcl2 的构象变化，从而消除其抗凋亡功能，将其从存活分子转变为细胞死亡诱导剂。 BDA-366 抑制肺癌细胞的生长。
T60202	MMRi62 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol	Ferroptosis	Apoptosis
	MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol) 是一种铁死亡 (ferroptosis) 诱导剂，靶向 MDM2-MDM4 (抑癌基因 p53 负调控因子)。MMRi62 对胰腺导管腺癌 (PDAC) 细胞显示出 p53 独立的促凋亡 (apoptosis) 活性，并诱导其自噬 (autophagy)。MMRi62 诱导铁死亡，伴随着活性氧增加和铁蛋白重链 (FTH1) 溶酶体降解。MMRi62 还可导致突变型 p53 的蛋白酶体降解，并对具有 KRAS 和 TP53 高频突变特征的原位异种移植 PDAC 小鼠模型具有体内药效。
T34335	RM-133 RM133
	RM-133 is a promising pro-apoptotic agent which shows activity on various cancer cell lines.
T36901	Pelcitoclax
	Pelcitoclax (APG-1252) is a powerful inhibitor of the Bcl-2 and Bcl-xl proteins, displaying significant antineoplastic and pro-apoptotic properties[1].
TP1611	Bim BH3, Peptide IV
	This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.
T26789	BH3I-2' BH3I2',BH3I 2'
	BH3I-2' is a cell-permeable BH3 mimetic. BH3I-2' induces apoptosis by specifically preventing BH3 domain-mediated interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family, thereby blocking the interaction between Bcl-x and Bak BH3 by targeting the Bcl-x binding pocket.
T80038	Bim BH3
	BimBH3，一种具有生物活性的肽，属于促凋亡Bcl-2蛋白家族。
TP1718	Bim BH3, Peptide IV TFA (721885-31-0 free base) Bim BH3, Peptide IV TFA
	Bim BH3, Peptide IV TFA is a 26-site residue of BH3 protein Bim, belonging to the pro-apoptotic group of bcl-2 protein family.
T29060	UNBS-1450 UNBS 1450,UBS1450,UBS-1450,UBS 1450
	UNBS-1450 is a sodium channel antagonist. UNBS-1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin, it is effective against various cancer cell types with an excellent differential toxicity. At low nanomolar concentrations, UNBS-1450 induce
T68027	(Z/E)-cp-461 free base
	CP-461是一种口服生物有效的第二代选择性凋亡抗肿瘤化合物(SAAND)和非甾体抗炎化合物(NSAID)舒林酸的类似物，具有潜在的促凋亡和抗肿瘤活性。
T11534L	Haemanthamine hydrochloride (466-75-1 free base) Haemanthamine hydrochloride	Others	Others
	Haemanthamine hydrochloride is an alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. It inhibits protein biosynthesis during the elongation stage of translation. It has antimalarial, pro-apoptotic, antiviral, antioxidant, an
T35270	YO-Pro 1 YO-Pro1,YO-Pro-1
	YO-Pro 1 是一种由苯并恶唑和喹啉环通过连接体连接而成的菁染料，在水中几乎没有荧光，但其荧光在插入双链DNA后大大增强，成为DNA浓度测定的基础，Ex/Em (结合DNA) = 491/509 nm。YO-Pro 1 可用于鉴定凋亡细胞。
T76030	Bim BH3, Peptide IV TFA
	BimBH3, Peptide IV TFA 是一种来自 BH3-only proteinBim 的 26 个残基肽，属于Bcl-2蛋白家族的促凋亡家族。
T69296	PHA-680626
	PHA-680626 is a potent and selective PLK inhibitor. PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinases. PHA-680626 inhibits Plk1 (IC50 = 0.53 μM), Plk2 (IC50 = 0.07 μM) and Plk3 (IC50 = 1.61 μM).
T71301	Opaganib HCl
	ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis a...
TP1966	Parstatin(mouse) Parstatin (mouse)
	Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apo
T76073	BH3 hydrochloride
	BH3 hydrochloride是一种能够穿透血脑屏障的多肽，其机制是通过直接激活促凋亡蛋白Bax/Bak或中和抗凋亡Bcl-2家族蛋白(Bcl-2、Bcl-XL、Bcl-w、mcl1和A-1)，从而诱导细胞凋亡。这一作用是通过与BH3结构域的结合实现的。
TP1965	Parstatin(human) Parstatin (human)
	Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apop
T70008	Bomedemstat ditosylate
	Bomedemstat, also known as IMG-7289, is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndrome, and Myelofibrosis. IMG-7289 selectively inhibited proliferation and induced apoptosis of JAK2 V617F cells by concomitantly increasing expression and methylation of p53, and, independently, the pro-apoptotic factor PUMA and by decreasing the levels of its antiapoptotic antago...
T63757	Bcl-2-IN-9
	Bcl-2-IN-9 是新型的、促凋亡的、细胞毒性低的 Bcl-2 抑制剂 (IC50: 2.9 μM)。Bcl-2-IN-9 能够下调 Bcl-2 表达，诱导癌细胞凋亡 (apoptosis)，并对白血病细胞表现出高选择性。
T76315	HKPao
	HKPao (Hunter-killer peptide ao) 是一种具有抗肥胖和抗肿瘤促凋亡活性的生物活性肽，能够促使细胞释放囊泡中的细胞色素 c。
T38042	Resolvin D4 Resolvin D4,RvD4
	Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid . [1] It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreated tissues from humans, mice, and sardines.[2][3] RvD4, at 10 ng/mouse, reduces neutrophil infiltration in zymosan A-induced peritonitis and, at 200 ng/mouse, diminishes neutrophil infiltration in response to S. aureus infection. [3] With isolated cells, RvD4 promotes phagocytosi...
T72570	Antitumor agent-83
	Antitumor agent-83 是一种促凋亡蛋白 BAX 的激活剂，对肿瘤细胞有显著的抗增殖作用。Antitumor agent-83 通过诱导 BAX 的构象激活介导细胞凋亡 (Apoptosis)，对 A549 细胞周期有抑制作用。Antitumor agent-83 具有良好的体外代谢稳定性和 CYP 谱。
T37166	RCTR1
	Resolvin conjugate in tissue regeneration 1 (RCTR1) is a specialized pro-resolving mediator (SPM) biosynthesized from docosahexaenoic acid by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils.1It has been found in human spleen and bone marrow.2RCTR1 is produced via lipoxygenase-mediated oxidation of DHA to 7(S)-8-epoxy-17(S)-HDHA, which is conjugated to glutathione.1,2,3RCTR1 (10 nM) increases phagocytosis ofE. colior apoptotic neutrophils in isolated human monocyte-de...
T28874	SU11652 SU-11652,SU 11652
	SU11652 is a potent cell-permeable pyrrole-indolinone compound. SU11652 acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor with greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGFR2, IC50 = 27 nM), FGFR1 (IC50= 170
T21911	Rilmenidine hemifumarate Rilmenidine (hemifumarate),S-3341 hemifumarate	Apoptosis; Imidazoline Receptor	Apoptosis; Neuroscience
	Rilmenidine hemifumarate (S-3341 hemifumarate) 是一种新型且具有口服活性和选择性的 I1咪唑啉受体 (I1 imidazoline receptor) 和α2肾上腺素受体激动剂，可诱导自噬，调节白血病细胞增殖，刺激促凋亡蛋白 Bax，诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。
T83751	PUMA BH3 (human) TFA
	PUMA BH3是一个由p53上调凋亡调节器(PUMA)的BH3域组成的肽，并激活促凋亡蛋白Bak。PUMA BH3与Bak结合（在HEPES和CHAPS缓冲液中的Kds分别为290和26 nM），诱导Bak同源寡聚化和Bak介导的膜透性增加。
T68656	Brivudine monophosphate
	Brivudine monophosphate is a phosphate ester of Brivudine. Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator...
T38043	Resolvin E4
	Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acid by 15-lipoxygenase (15-LO)via15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE intermediatesin vitroand by isolated human M2 macrophages or polymorphonuclear (PMN) neutrophils under normoxic or hypoxic conditions. RvE4 synthesis is enhanced in M2 macrophage and neutrophil co-cultures, indicating transcellular biosynthesis by a potential 15-LO and 5-LO mechanism...
T80226	r8 Bid BH3
	r8 Bid BH3是一种促凋亡的生物活性肽，属于"BCL-2家族"中的“仅具BH3功能域”的亚群，对Bcl-2表达的人类白血病细胞系显示出致死性。作为Bcl-2拮抗剂，它具备治疗癌症的潜力。此外，多聚-D-精氨酸（d-异构体，标记为rrrrrrrr）被融合到Bid BH3肽上，以提高其被细胞摄取的能力。
T79919	S-Adenosyl-L-methionine (1,4-butanedisulfonate) Ademetionine (1,4-butanedisulfonate),S-Adenosyl methionine (1,4-butanedisulfonate),AdoMet (1,4-butanedisulfonate)	Endogenous Metabolite	Metabolism
	S-Adenosyl-L-methionine (S-Adenosyl methionine) 1,4-butanedisulfonate 作为一种口服活性的甲基供体，它是一种膳食补充剂，对抗抑郁和缓解疼痛具有显著功效。此化合物在癌症治疗中显示了抗增殖、促进凋亡和阻止转移的潜在作用。同时，S-Adenosyl-L-methionine 1,4-butanedisulfonate 也用于肝病和骨关节炎的相关研究。
T64158	Nenocorilant
	Nenocorilant (Relacorilant) 是一种口服具有活力的糖皮质激素受体 (GR) 拮抗剂 (Ki: 0.15 nM)。Nenocorilant 能够促进细胞凋亡 (pro-apoptotic)，联合细胞毒性药物后能够提高药效。Nenocorilant 能够用于研究肿瘤。
T80224	Bid BH3 (80-99)
	Bid BH3 (80-99) 是一种具有促凋亡功能的生物活性肽，属于BCL-2蛋白家族中的"BH3仅限"(BOPS)亚群。作为第一个能够结合并激活Bcl-2、Bax和Bak的BOP，Bid扮演引发细胞凋亡的关键角色。它通过从细胞质迁移到线粒体膜来失活Bcl-2或激活Bax。特别地，在N末端位置的谷氨酰胺(Q)或谷氨酸(E)，会自然转化为pGlu形式，其疏水性γ-内酰胺环被认为有助于增强肽针对胃肠道蛋白酶的稳定性。焦谷氨酰肽通常被划分为这类生物活性肽的一个常见子集，并且在HPLC分析中，作为评估肽纯度的重要指标被考虑在内。
T36410	9(E),11(E),13(E)-Octadecatrienoic Acid
	9(E),11(E),13(E)-Octadecatrienoic acid (β-ESA) is a conjugated polyunsaturated fatty acid that is found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linolenic acid. It reduces growth of Caco-2 colon cancer cells in a dose-dependent and time-dependent manner. In vitro, β-ESA induces DNA fragmentation and upregulation of pro-apoptotic Bax mRNA. β-ESA decreases protein expression of the apoptosis suppression factor Bcl-2 and induces a...

化合物

Cat.No: T21919

Target: Apoptosis

Cat.No: T23861

Synonym: CAY-10526,BTH,CAY 10526

Target: Prostaglandin Receptor

SCH79797 dihydrochloride

Cat.No: T12870

Target: Apoptosis, Others, Protease-activated Receptor

Tumor targeted pro-apoptotic peptide

Cat.No: T76371

Ethylene dimethanesulfonate

Cat.No: T13689

Target: Apoptosis

Cat.No: T77662

Target: Apoptosis

Cat.No: T4212

Target: Hippo pathway

(S)-Thalidomide

Cat.No: T12644L

Synonym: (S)-(-)-Thalidomide

Target: Apoptosis

Bcl-B inhibitor 1

Cat.No: T77571

Target: Apoptosis, BCL

2’-OMe-Guanosine

Cat.No: T9726

Target: Apoptosis, Nucleoside Antimetabolite/Analog

Cat.No: T77332

Target: BCL, PKC

(S)-Enitociclib

Cat.No: T70388

Synonym: VIP152

Target: CDK

Cat.No: T31020

Synonym: OSI 461,UNII-68OJX9I7DT,CP-461,CP461

Target: Apoptosis, PDE

Cat.No: T10827

Synonym: TMCB

Target: Apoptosis, ERK, Casein Kinase, Pim, DYRK

Cat.No: T10706

Target: Mitochondrial Metabolism

Cat.No: T2129

Target: PDE

Cat.No: T6778

Target: BCL

Cat.No: T60202

Synonym: 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol

Target: Ferroptosis

Cat.No: T34335

Synonym: RM133

Cat.No: T36901

Bim BH3, Peptide IV

Cat.No: TP1611

Cat.No: T26789

Synonym: BH3I2',BH3I 2'

Cat.No: T80038

Bim BH3, Peptide IV TFA (721885-31-0 free base)

Cat.No: TP1718

Synonym: Bim BH3, Peptide IV TFA

Cat.No: T29060

Synonym: UNBS 1450,UBS1450,UBS-1450,UBS 1450

(Z/E)-cp-461 free base

Cat.No: T68027

Haemanthamine hydrochloride (466-75-1 free base)

Cat.No: T11534L

Synonym: Haemanthamine hydrochloride

Target: Others

Cat.No: T35270

Synonym: YO-Pro1,YO-Pro-1

Bim BH3, Peptide IV TFA

Cat.No: T76030

Cat.No: T69296

Cat.No: T71301

Parstatin(mouse)

Cat.No: TP1966

Synonym: Parstatin (mouse)

BH3 hydrochloride

Cat.No: T76073

Parstatin(human)

Cat.No: TP1965

Synonym: Parstatin (human)

Bomedemstat ditosylate

Cat.No: T70008

Cat.No: T63757

Cat.No: T76315

Cat.No: T38042

Synonym: Resolvin D4,RvD4

Antitumor agent-83

Cat.No: T72570

Cat.No: T37166

Cat.No: T28874

Synonym: SU-11652,SU 11652

Rilmenidine hemifumarate

Cat.No: T21911

Synonym: Rilmenidine (hemifumarate),S-3341 hemifumarate

Target: Apoptosis, Imidazoline Receptor

PUMA BH3 (human) TFA

Cat.No: T83751

Brivudine monophosphate

Cat.No: T68656

Cat.No: T38043

Cat.No: T80226

S-Adenosyl-L-methionine (1,4-butanedisulfonate)

Cat.No: T79919

Synonym: Ademetionine (1,4-butanedisulfonate),S-Adenosyl methionine (1,4-butanedisulfonate),AdoMet (1,4-butanedisulfonate)

Target: Endogenous Metabolite

Cat.No: T64158

Bid BH3 (80-99)

Cat.No: T80224

9(E),11(E),13(E)-Octadecatrienoic Acid

Cat.No: T36410

Cat. No.	Product Name	Target	Signaling Pathways
T8193	α-Thujone Thujone,ALPHA-(-)-THUJONE,α-侧柏酮,(-)-α-侧柏酮	Apoptosis; Reactive Oxygen Species; GABA Receptor; AChR; Parasite; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	α-Thujone 是一种从西方金钟柏精油中分离出来的单萜，可穿透血脑屏障。它是 GABAA 受体的可逆调节剂，在抑制 GABA 诱导的电流时，它的 IC50为 21 μM。它诱导 ROS 依赖性细胞毒性，还诱导细胞凋亡和自噬。它具有抗伤害，抗肿瘤、杀虫和驱虫活性。
T13903	Stearoylethanolamide N-(2-Hydroxyethyl)octadecanamide	Apoptosis	Apoptosis
	Stearoylethanolamide(N-(2-Hydroxyethyl)octadecanamide) 是一种存在于人、大鼠和小鼠大脑中的大麻素类化合物，具有促细胞凋亡活性。
T13864	Resolvin D1 RvD1	Apoptosis	Apoptosis
	Resolvin D1 (RvD1) 是一种内源性促进炎症消解介质，可通过调节肌动蛋白聚合阻断促进炎症的中性粒细胞迁移，减少 TNF-α 介导的炎症在巨噬细胞中的作用，并增强巨噬细胞对凋亡细胞的吞噬作用。
T3395	Timosaponin AIII Filiferin B,知母皂苷 A-III,AneMarsaponin A3,Timosaponin A3	AChE; mTOR	Neuroscience; PI3K/Akt/mTOR signaling
	Timosaponin AIII (Timosaponin A3) 是一种乙酰胆碱酯酶活性抑制剂，其IC50=35.4 μM。
T5679	(E)-Ferulic acid trans-Ferulic acid,反式阿魏酸,(E)-Coniferic acid	BCL; Ferroptosis; Wnt/beta-catenin; Endogenous Metabolite	Apoptosis; Cytoskeletal Signaling; Metabolism; Stem Cells
	(E)-Ferulic acid ((E)-Coniferic acid) 是阿魏酸的异构体，阿魏酸是在植物细胞壁中丰富存在的芳香族天然产物。它引起 β-catenin 的磷酸化，导致其蛋白酶体降解，增加促凋亡因子 Bax 的表达，降低促生存因子的表达。它在人肺癌细胞系 H1299 中发挥抗增殖和抗迁移作用。
T3862	Irigenin	NF-κB; Integrin	Cytoskeletal Signaling; NF-κB
	Irigenin 可通过特异性和选择性地阻断 Extra Domain A 域的 C-C 环上α9β1和α4β1整合素结合位点，介导其抗转移作用。可通过增强胃癌细胞中促凋亡分子的表达来敏化 TRAIL 诱导的凋亡，具有抗癌作用。
T36715	Tetrac Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tetrac (Tetraiodothyroacetic acid)是L-甲状腺素(T4)的衍生物，是一种甲状腺整合素受体拮抗剂。Tetrac通过阻断EGFR介导的结直肠癌细胞信号传导来诱导抗增殖。Tetrac 可阻断 T4 和 3,5,3'-triiodo-L-thyronine (T3)在细胞表面甲状腺素整合素 αvβ3 受体上的作用。Tetra 具有抗血管生成、抗肿瘤活性和促凋亡活性。
TCS2170	2,5-Dihydroxyacetophenone Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,2 '，5'-二羟基苯乙酮,Acetylhydroquinone,2,5-二羟基苯乙酮,DHAP	ERK; NF-κB; Tyrosinase	MAPK; NF-κB; Proteases/Proteasome
	2,5-Dihydroxyacetophenone (Quinacetophenone) 是从熟地黄中分离出的一种天然产物，通过阻断 ERK1/2和 NF-κB 信号通路，抑制活化巨噬细胞中炎症介质的产生。
T11534	Haemanthamine	Others	Others
	Haemanthamine is an alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. It inhibits protein biosynthesis during the elongation stage of translation. It has antimalarial, pro-apoptotic, antiviral, antioxidant, and anticonvulsa
TMA1743	Ergosterol peroxide	ERK; VEGFR; p38 MAPK; Wnt/beta-catenin; Akt; JAK; CDK; JNK; STAT; Antifection	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pro-apoptotic protein Puma and Bax to
TN1543	Cynaropicrin	IL Receptor; Others; TNF	Apoptosis; Immunology/Inflammation; Others
	Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential anticancer agent against some leukocyte cancer cells such as lymphoma or leukemia, through pro-
T73813	Haemanthamine hydrochloride
	Haemanthamine hydrochloride 是从Amaryllidaceae 植物中分离出来的一种蛇毒碱样生物碱，具有强大的抗癌活性。Haemanthamine hydrochloride 靶向核糖体以在翻译的延长阶段抑制蛋白质的生物合成。Haemanthamine hydrochloride 具有促凋亡，抗氧化剂，抗病毒，抗疟疾和抗惊厥活性。
TMA0918	Neochamaejasmine A	Caspase	Apoptosis; Proteases/Proteasome
	Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating the p21 protein and ultimately pro

天然产物

Cat.No: T8193

Synonym: Thujone,ALPHA-(-)-THUJONE,α-侧柏酮,(-)-α-侧柏酮

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, AChR, Parasite, Autophagy

Stearoylethanolamide

Cat.No: T13903

Synonym: N-(2-Hydroxyethyl)octadecanamide

Target: Apoptosis

Cat.No: T13864

Synonym: RvD1

Target: Apoptosis

Timosaponin AIII

Cat.No: T3395

Synonym: Filiferin B,知母皂苷 A-III,AneMarsaponin A3,Timosaponin A3

Target: AChE, mTOR

(E)-Ferulic acid

Cat.No: T5679

Synonym: trans-Ferulic acid,反式阿魏酸,(E)-Coniferic acid

Target: BCL, Ferroptosis, Wnt/beta-catenin, Endogenous Metabolite

Cat.No: T3862

Target: NF-κB, Integrin

Cat.No: T36715

Synonym: Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid

Target: Apoptosis, EGFR

2,5-Dihydroxyacetophenone

Cat.No: TCS2170

Synonym: Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,2 '，5'-二羟基苯乙酮,Acetylhydroquinone,2,5-二羟基苯乙酮,DHAP

Target: ERK, NF-κB, Tyrosinase

Cat.No: T11534

Target: Others

Ergosterol peroxide

Cat.No: TMA1743

Target: ERK, VEGFR, p38 MAPK, Wnt/beta-catenin, Akt, JAK, CDK, JNK, STAT, Antifection

Cat.No: TN1543

Target: IL Receptor, Others, TNF

Haemanthamine hydrochloride

Cat.No: T73813

Neochamaejasmine A

Cat.No: TMA0918

Target: Caspase

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