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Search Results for " neutrophils "

100

抑制剂 & 化合物

25

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T39437	Cevidoplenib dimesylate	Syk	Angiogenesis; Tyrosine Kinase/Adaptors
	Cevidoplenib dimesylate 是一种脾酪氨酸激酶 (Syk) 抑制剂，具有抗炎和免疫调节特性。
T21815	ONO-RS-082	Others	Others
	ONO-RS-082 是磷脂酶 A 抑制剂。它抑制PLA2的IC50值为1.0 μM，但即使浓度达到 100 μM 也不抑制 PLC。
TQ0105	CAY10650	Phospholipase	Metabolism
	CAY10650 是高效的胞浆磷脂酶A2α抑制剂，IC50=12 nM，能够抑制脂滴形成和 PGE2 分泌。
T17250	W-54011	ROS; Complement System	Immunology/Inflammation
	W-54011 是口服有效的非肽 C5a 受体拮抗剂，抑制125I 标记的 C5a 与人嗜中性白细胞的结合，Ki 为 2.2 nM。它还抑制C5a 诱导的人嗜中性粒细胞的细胞内 Ca2+动员，趋化性和ROS 的生成，IC50分别为 3.1 nM、2.7 nM 和1.6 nM。
T8930	CID44216842 KUC103479N-02	CDK; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	CID44216842 (KUC103479N-02) 是Cdc42选择性抑制剂。在 GDP 结合测定中，它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 0.3 和 0.5 μM。在 GTP 结合测定中，它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 1.0 和 1.2 μM。它可用作分子探针。
T8531	m-3M3FBS 2,4,6-三甲基-N-[3-(三氟甲基)苯基]苯磺酰胺	Apoptosis; Phospholipase	Apoptosis; Metabolism
	m-3M3FBS 是一种有效的磷脂酶C 激活剂，刺激人中性粒细胞产生超氧物，上调细胞内钙离子浓度，刺激多种细胞产生磷酸肌醇。它诱导单核细胞白血病细胞凋亡。
T1076	Dexamethasone MK 125,Prednisolone F,NSC 34521,Hexadecadrol,地塞米松	Glucocorticoid Receptor; Mitophagy; IL Receptor; SARS-CoV; Antibacterial; Antibiotic; Autophagy; Complement System	Autophagy; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology
	Dexamethasone (Hexadecadrol) 是一种糖皮质激素受体激动剂和一种 IL 受体调节剂。Dexamethasone 具有抗炎和免疫抑制活性，可诱导自噬。Dexamethasone 抑制 LPS 诱导的巨噬细胞炎症反应。
T40446	AG-09/1	Others	Others
	AG-09/1 是一种具有选择性和有效性的甲酰基肽受体 1 (FPR1) 激动剂，可激活人中性粒细胞的趋化作用。
T72322	R 59-022 hydrochloride DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride	5-HT Receptor; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; Neuroscience
	R 59-022 hydrochloride (DKGI-I hydrochloride) 是一种 5-HT Receptor 拮抗剂，可激活蛋白激酶 C (PKC)。R 59-022 hydrochloride 是一种 DGK 抑制剂 (IC50:2.8 µM),可抑制 OAG 磷酸化为 OAPA。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生，并抑制嗜中性粒细胞中磷脂酸的产生。
TP1672L	N-Formyl-Met-Ala-Ser TFA(17351-32-5 free base)	Others	Others
	N-Formyl-Met-Ala-Ser TFA(17351-32-5 free base) 是一种肽，与中性粒细胞上的甲酰肽受体结合。N-Formyl-Met-Ala-Ser 肽 (fMet-Ala-Ser) 与中性粒细胞上的甲酰肽受体结合。含有 N-甲酰甲硫氨酸的肽包括有效和已知的成员 N-甲酰-Met-Leu-Phe（FMLP 或 fMet-Leu-Phe）通过受体依赖性机制刺激人中性粒细胞。
T1639	Amlexanox 氨来呫诺,CHX3673,Amoxanox,氨来诺,AA673	IL Receptor; FGFR; Others; IκB/IKK	Angiogenesis; Immunology/Inflammation; NF-κB; Others; Tyrosine Kinase/Adaptors
	Amlexanox (AA673) 是一种特异性的 IKKε和 TBK1抑制剂，其 IC50=1-2 μM。
T9878	Croconazole	Lipoxygenase; LTR	Immunology/Inflammation; Metabolism
	Croconazole 对中性粒细胞的 5-脂氧合酶 (5-LOX) 表现出剂量依赖性抑制活性。Croconazole 是一种抗真菌剂。Croconazole 对合成白三烯 B4 (LTB4) 和 5-羟基二十碳四烯酸 (5-HETE) 的 IC50 分别为 7.8 ± 1.7 和 7.6 ± 0.3 μM。
T0468	Lidocaine Lignocaine,Alphacaine,Xylocaine,利多卡因	Apoptosis; ERK; NF-κB; MEK; Sodium Channel; Histamine Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Neuroscience; NF-κB
	Lidocaine (Alphacaine) 是一种酰胺衍生物，抑制涉及复杂电压和依赖性的钠通道，可用于研究室性心律失常。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。
T77638	BIRM 271	Phospholipase; LTR	Immunology/Inflammation; Metabolism
	BIRM 271 是一种新型花生四烯酸释放抑制剂，可阻断白三烯B4和人中性粒细胞中的血小板活化因子生物合成。BIRM 271 和 BIRM 270 属于对映异构体，对白三烯B4 的产生有抑制作用，IC50 为40 nM。
TP1168	N-Formyl-Met-Leu-Phe-Lys fMLFK	Others	Others
	N-Formyl-Met-Leu-Phe-Lys (fMLFK) 是一种多肽，是选择性FPR1激动剂，作用于 FPR1(IC50:3.5 nM)，FPR2(IC50:6.7 nM) 和 FPR2-D2817.32G(IC50:0.88 nM) 。
T14138	AG-825 Tyrphostin AG-825	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	AG-825（Tyrphostin C15）是一种具有选择性和竞争性且抑制酪氨酸磷酸化的 ErbB2 抑制剂，其 IC50 值为 0.35 μM。AG-825（Tyrphostin C15）对 HER2 具有抑制作用，在小鼠乳腺癌异种模型中显示出抗癌活性。AG-825（Tyrphostin C15）是一种潜在的克服锰诱导的神经毒性或阿尔茨海默病发展的活性分子，能促进人中性粒细胞的凋亡，可用于研究乳腺癌。
T38287	C3a Receptor Agonist C3a receptor agonist 1,C3a受体激动剂,Complement 3a Receptor Agonist	Complement System	Immunology/Inflammation
	C3a Receptor Agonist (C3a receptor agonist 1) 结合免疫系统补体途径中的G 蛋白偶联C3a 受体(C3aRs)。在肠缺血再灌注损伤模型中，C3aR 的激活可防止中性粒细胞动员。C3aRs 在成年小鼠的神经祖细胞和未成熟神经元上表达。C3a 在体外刺激神经祖细胞的分化。
T22526	BML-111 5(S),6(R)-7-trihydroxymethyl Heptanoate	Others	Others
	inhibits leukotriene B4 (LTB4)-induced polymorphonuclear neutrophils (PMN) chemotaxis
T30916	CI 922 CI-922,UNII-5VC7KY707F,CI922
	CI 922 is an anaphylaxis mediator release inhibitor. It inhibits the activation of human neutrophils.
T37278	2-chloro Stearic Acid
	2-chloro Stearic acid is a bioactive fatty acid that accumulates in primary human monocytes and neutrophils as well as murine neutrophils stimulated with phorbol 12-myristate 13-acetate . It induces DNA release from primary human neutrophils. 2-chloro Stearic acid is toxic to C. quinquefasciatus larvae (LC50 = <1 ppm).
T37303	5-OxoETE 5-KETE,5-OxoETE
	5-OxoETE is a polyunsaturated keto acid formed by the oxidation of 5-HETE in human neutrophils by a specific dehydrogenase.[1] It stimulates cytosolic calcium levels in neutrophils with an EC50 value of 2 nM.[2] 5-OxoETE selectively stimulates the migration and degranulation of eosinophils and activates the MAPK pathway in stimulated neutrophils via a specific G protein-coupled receptor.[3],[4],[5],[6]
T41134	Defensin HNP-2 human
	Defensin HNP-2 is a naturally occurring antibiotic and monocyte chemotactic peptide synthesized by human neutrophils.
T26699	AZ10397767 AZ 10397767,AZ-10397767
	AZ10397767 is a potent CXCR2 antagonist (IC50 = 1 nM). AZ10397767 significantly reduced the numbers of infiltrating neutrophils into both in vitro and in vivo tumor models.
T36043	17(R)-Protectin D1 17(R)-Protectin D1
	17(R)-Protectin D1 is an aspirin-triggered epimer of the specialized pro-resolving mediator protectin D1 .1It decreases leukotriene B4-induced transendothelial migration of human polymorphonuclear (PMN) neutrophils when used at concentrations ranging from 0.1 to 10 nM. 17(R)-Protectin D1 (0.01-10 ng) reduces the recruitment of neutrophils in a mouse model of TNF-α-induced peritonitis. 1.Serhan, C.N., Fredman, G., Yang, R., et al.Novel proresolving aspirin-triggered DHA pathwayChem. Biol.18(18)97...
T26523	Abroquinone A
	Abroquinone A, a natural isoflavanquinone, has been shown to block cytosolic phospholipase A(2) and 5-lipoxygenase activation in neutrophils, it may have pharmaceutical potential as an antiallergic agent.
T81316	Rabbit neutrophil peptide 3b
	Rabbit Neutrophil Peptide 3b，一种源自兔腹膜中性粒细胞的抗菌肽。
T75748	Indolicidin TFA
	Indolicidin TFA 是一种从牛中性粒细胞的细胞质颗粒中纯化的强效抗菌肽。
T36221	2-chloro Palmitic Acid
	2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endot...
T37967	12(S)-HEPE
	12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of ω-3 fatty acids.
T35968	Nitrosobenzene
	Nitrosobenzene is a spin trap that has been used in the study of oxidative DNA damage and nitroso-compound-induced respiratory burst in neutrophils.
TP1672	N-Formyl-Met-Ala-Ser
	N-Formyl-Met-Ala-Ser is a peptide, binds to formyl peptide receptors on neutrophils.N-Formyl-Met-Ala-Ser Peptide (fMet-Ala-Ser) binds to formyl peptide receptors on neutrophils. N-Formylmethionine-containing peptides including the most potent and known me
T37617	Leukotriene B3
	LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects. However, LTB3 is five times less potent than LTB4 in eliciting chemotaxis of human neutrophils.
T37618	Leukotriene B4 dimethyl amide Leukotriene B4 dimethyl amide
	LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on guinea pig lung membranes.
T38043	Resolvin E4
	Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acid by 15-lipoxygenase (15-LO)via15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE intermediatesin vitroand by isolated human M2 macrophages or polymorphonuclear (PMN) neutrophils under normoxic or hypoxic conditions. RvE4 synthesis is enhanced in M2 macrophage and neutrophil co-cultures, indicating transcellular biosynthesis by a potential 15-LO and 5-LO mechanism...
T10454	Bactenecin 抗菌肽,Bactenecin, bovine	Antibacterial	Microbiology/Virology
	Bactenecin is a cyclic antimicrobial peptide isolated from bovine neutrophils with potent activity against Bacterial and Fungal species.
TP1864	[Glu1]-Fibrinopeptide B [Glu1]-纤维蛋白肽B
	[Glu1]-Fibrinopeptide B, a derivative of fibrinopeptide B amino acid residues 1-14, originates from human fibrinopeptide B (hFpB). hFpB is a proteolytic cleavage product of the fibrinogen B beta-chain, specifically generated by thrombin, which plays a significant role in activating neutrophils (PMN), monocytes, and fibroblasts.
T80323	Bovine neutrophil beta-defensin 12 BNBD-12
	Bovine neutrophil beta-defensin 12，一种牛中性粒细胞来源的抗菌肽，展现针对大肠杆菌(Escherichia coli)和金黄色葡萄球菌(Staphylococcus aureus)的抗菌活性。
T35773	Gliotoxin-13C13 Gliotoxin-13C13
	Gliotoxin-13C13is intended for use as an internal standard for the quantification of gliotoxin by GC- or LC-MS. Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains ofAspergillusand other fungi with diverse biological activities.1,2,3,4,5,6,7,8It inhibits 20S proteasomal chymotrypsin activity (IC50= 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB.2,3Gliotoxin induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutr...
T36604	(±)5-HETE
	(±)5-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. It contains equal amounts of 5(S)-HETE and 5(R)-HETE. (±)5-HETE induces the aggregation of isolated neutrophils with an IC50 value of 200 nM.[1]
T81279	RhB-PBP10 TFA
	RhB-PBP10 TFA，一种Rhodamine B 标记的PBP10 TFA （FPR2 拮抗剂），有效选择性地抑制FPRL1 在中性粒细胞中诱导的颗粒动员以及氧自由基的分泌。
T38157	Ricinelaidic Acid
	Ricinelaidic acid is a 12-hydroxy fatty acid and an antagonist of leukotriene B4 (LTB4) receptors (Ki = 2 μM in porcine neutrophil membranes). It inhibits chemotaxis and calcium flux induced by LTB4 in isolated human neutrophils (IC50s = 10 and 7 μM, respectively). Ricinelaidic acid (1 mg/kg, i.v.) inhibits bronchoconstriction induced by LTB4 in rats by 46%.
TP1919	Ac2-12
	Annexin/lipocortin 1-mimetic peptide; inhibits leukocyte extravasation. Reduces neutrophil adhesion and emigration, and promotes detachment of neutrophils from activated mesenteric endothelium in mice in vivo.
T38087	20-hydroxy Leukotriene B4 20-hydroxy Leukotriene B4
	20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2...
T38354	Lactosylsphingosine (d18:1) Lactosylsphingosine (d18:1)
	Lactosylsphingosine is a bioactive sphingolipid and a form of lactosylceramide that is lacking the fatty acyl group. Lyso-lactosylceramide (1-50 μM) reduces viability of human neutrophils in a concentration-dependent manner. Unlike lactosylceramide,lactosylsphingosine has no effect on protein synthesis and cell proliferation in cardiomyocytes. Lactosylsphingosine is a precursor in the synthesis of lyso-ganglioside GM3.
TP1948	PBP10 PBP 10
	Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro and blocks cell motility. Also exh
T37166	RCTR1
	Resolvin conjugate in tissue regeneration 1 (RCTR1) is a specialized pro-resolving mediator (SPM) biosynthesized from docosahexaenoic acid by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils.1It has been found in human spleen and bone marrow.2RCTR1 is produced via lipoxygenase-mediated oxidation of DHA to 7(S)-8-epoxy-17(S)-HDHA, which is conjugated to glutathione.1,2,3RCTR1 (10 nM) increases phagocytosis ofE. colior apoptotic neutrophils in isolated human monocyte-de...
T61356	CXCR2 antagonist 3
	CXCR2 antagonist 3 (compound 11h) is a highly effective antagonist of CXC chemokine receptor 2 (CXCR2). It displays potent activity in inhibiting neutrophil infiltration into the air pouch, with double-digit nanomolar potencies against CXCR2. Moreover, CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs, while enhancing the infiltration of CD3+ T lymphocytes into Pan02 tumor tissues [1].
TP1891	MMK 1
	Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proi
T36606	(±)7-HDHA
	(±)7-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Enzymatic transformation of DHA by RBL-1 cells and human neutrophils also produces 7-HDHA. However, the enzymatic product is most likely the S-isomer. (±)7-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant polyunsaturated fatty acid.
T37648	5(R)-HETE
	5(R)-HETE is a rare lipoxygenase product of arachidonic acid. Nearly all plant and animal 5-LOs produce 5(S)-HETE, but the presence of a 5(R)-LO and the synthesis of 5(R)-HpETE and 5(R)-HETE have been confirmed in oocytes of the bivalve mollusk, S. solidissima. 5(R)-HETE is more potent than the (S)-enantiomer as a chemotactic agent for human neutrophils.

化合物

Cevidoplenib dimesylate

Cat.No: T39437

Target: Syk

Cat.No: T21815

Target: Others

Cat.No: TQ0105

Target: Phospholipase

Cat.No: T17250

Target: ROS, Complement System

Cat.No: T8930

Synonym: KUC103479N-02

Target: CDK, Ras

Cat.No: T8531

Synonym: 2,4,6-三甲基-N-[3-(三氟甲基)苯基]苯磺酰胺

Target: Apoptosis, Phospholipase

Cat.No: T1076

Synonym: MK 125,Prednisolone F,NSC 34521,Hexadecadrol,地塞米松

Target: Glucocorticoid Receptor, Mitophagy, IL Receptor, SARS-CoV, Antibacterial, Antibiotic, Autophagy, Complement System

Cat.No: T40446

Target: Others

R 59-022 hydrochloride

Cat.No: T72322

Synonym: DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride

Target: 5-HT Receptor, PKC

N-Formyl-Met-Ala-Ser TFA(17351-32-5 free base)

Cat.No: TP1672L

Target: Others

Cat.No: T1639

Synonym: 氨来呫诺,CHX3673,Amoxanox,氨来诺,AA673

Target: IL Receptor, FGFR, Others, IκB/IKK

Cat.No: T9878

Target: Lipoxygenase, LTR

Cat.No: T0468

Synonym: Lignocaine,Alphacaine,Xylocaine,利多卡因

Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel, Histamine Receptor

Cat.No: T77638

Target: Phospholipase, LTR

N-Formyl-Met-Leu-Phe-Lys

Cat.No: TP1168

Synonym: fMLFK

Target: Others

Cat.No: T14138

Synonym: Tyrphostin AG-825

Target: Apoptosis, EGFR

C3a Receptor Agonist

Cat.No: T38287

Synonym: C3a receptor agonist 1,C3a受体激动剂,Complement 3a Receptor Agonist

Target: Complement System

Cat.No: T22526

Synonym: 5(S),6(R)-7-trihydroxymethyl Heptanoate

Target: Others

Cat.No: T30916

Synonym: CI-922,UNII-5VC7KY707F,CI922

2-chloro Stearic Acid

Cat.No: T37278

Cat.No: T37303

Synonym: 5-KETE,5-OxoETE

Defensin HNP-2 human

Cat.No: T41134

Cat.No: T26699

Synonym: AZ 10397767,AZ-10397767

17(R)-Protectin D1

Cat.No: T36043

Synonym: 17(R)-Protectin D1

Cat.No: T26523

Rabbit neutrophil peptide 3b

Cat.No: T81316

Indolicidin TFA

Cat.No: T75748

2-chloro Palmitic Acid

Cat.No: T36221

Cat.No: T37967

Cat.No: T35968

N-Formyl-Met-Ala-Ser

Cat.No: TP1672

Cat.No: T37617

Leukotriene B4 dimethyl amide

Cat.No: T37618

Synonym: Leukotriene B4 dimethyl amide

Cat.No: T38043

Cat.No: T10454

Synonym: 抗菌肽,Bactenecin, bovine

Target: Antibacterial

[Glu1]-Fibrinopeptide B

Cat.No: TP1864

Synonym: [Glu1]-纤维蛋白肽B

Bovine neutrophil beta-defensin 12

Cat.No: T80323

Synonym: BNBD-12

Gliotoxin-13C13

Cat.No: T35773

Synonym: Gliotoxin-13C13

Cat.No: T36604

Cat.No: T81279

Ricinelaidic Acid

Cat.No: T38157

Cat.No: TP1919

20-hydroxy Leukotriene B4

Cat.No: T38087

Synonym: 20-hydroxy Leukotriene B4

Lactosylsphingosine (d18:1)

Cat.No: T38354

Synonym: Lactosylsphingosine (d18:1)

Cat.No: TP1948

Synonym: PBP 10

Cat.No: T37166

CXCR2 antagonist 3

Cat.No: T61356

Cat.No: TP1891

Cat.No: T36606

Cat.No: T37648

Cat. No.	Product Name	Target	Signaling Pathways
T8288	14-Deoxyandrographolide 去氧穿心莲内酯,14-去氧穿心莲内酯	Apoptosis; Others	Apoptosis; Others
	14-Deoxyandrographolide 是穿心莲中的一种天然产物，是一种钙通道阻断剂，具有保肝功效。它通过诱导 TNFRSF1A 的释放，使肝细胞对 TNF-α 介导的凋亡脱敏。
TN1933	Mitraphylline 帽柱木菲碱,帽柱叶碱	IL Receptor; TNF; NF-κB	Apoptosis; Immunology/Inflammation; NF-κB
	Mitraphylline 是一种绒毛钩藤中主要的五环吲哚类生物碱，可阻碍脂多糖介导的原代人中性粒细胞活化。
TN6647	4-O-Cinnamoylquinic acid 金银花	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	4-O-Cinnamoylquinic acid 是从 Casearia grewiifolia 干果中提取出来的小分子化合物，对前列腺素有抑制作用，抑制人中性粒细胞中超氧阴离子的生成。
TN2286	Tsugaric acid A	NO Synthase	Immunology/Inflammation
	Tsugaric acid A 能够显著抑制超氧阴离子的形成，还可以保护人类角质形成细胞，使其免受紫外线 B 诱导的损害。
T5S1897	Linderalactone	Apoptosis; Others; JAK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells
	Linderalactone 是从乌药中分离出来的一种倍半萜烯内酯，通过调节凋亡相关蛋白的表达和抑制 JAK/STAT 信号通路来抑制癌细胞生长。它以 IC50值为 15 µM 来抑制肺癌 A-549 细胞的增殖。
TN7224	2,2'-Dihydroxy chalcone	Antibacterial; Autophagy	Autophagy; Microbiology/Virology
	2,2'-Dihydroxy chalcone 是一种用 fMLP/CB 刺激的大鼠中性粒细胞释放β-葡糖醛酸酶（IC50=1.6±0.2μM）和溶菌酶（IC50=1.4±0.2μM）的有效抑制剂。2,2'-Dihydroxy chalcone 对大肠杆菌、福氏志贺氏菌、白葡萄球菌和金黄色葡萄球菌有抑菌活性。
TN3469	Aucuparin 2,6-dimethoxy-4-phenylphenol	NADPH-oxidase	Immunology/Inflammation
	Aucuparin (2,6-dimethoxy-4-phenylphenol) 是一种植物抗菌素，具有抗炎活性。在博来霉素 (BLM) 诱导的肺纤维化小鼠模型中，Aucuparin 抑制肺纤维化。在经ABTS 和FRAP 测定显示出明显的清除活性。 Aucuparin 对fmlp 诱导的人中性粒细胞产生超氧化物具有明显的抑制作用，其IC50为17.0μM。
T5280	3-Chloro-L-Tyrosine 3-氯-L-酪氨酸,3-Chlorotyrosine,Chlorotyrosine	Others; Endogenous Metabolite	Metabolism; Others
	3-Chloro-L-Tyrosine (Chlorotyrosine) 是一种髓过氧化物酶催化氧化的特异性标志物，在从人动脉粥样硬化内膜分离的低密度脂蛋白中显著升高。
T40615	N,N'-Dimethylthiourea N,N-二甲基硫脲,DMTU	Antioxidant	oxidation-reduction
	N,N'-Dimethylthiourea (DMTU) 是一种分离自黑蒜的化合物。N,N'-Dimethylthiourea 具有口服活性的羟基自由基 (•OH) 的清除剂，通过活化的中性粒细胞在体外阻止 •OH 的产生。N,N'-Dimethylthiourea 通过发挥 •OH 清除和抗炎作用，防止水浸限制应激诱导的大鼠胃粘膜损伤。
TN1448	(-)-Bornyl acetate L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯	p38 MAPK; NF-κB; JNK; Antifungal	MAPK; Microbiology/Virology; NF-κB
	(-)-Bornyl acetate (L-(-)-Bornyl acetate) 是存在于牛膝草油中的一种具有抗真菌活性的 (+)-Bornyl acetate 低活性异构体。
T38097	Antibiotic PF 1052
	Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also in...
TN4317	Isopedicin	NADPH-oxidase; cAMP; p38 MAPK; PKA; JNK; PDE	GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism; Tyrosine Kinase/Adaptors
	Isopedicin has anti-inflammatory functions, it inhibits the O(2)()(-) production in human neutrophils* by an elevation of cellular cAMP and activation of PKA through its inhibition of cAMP-specific PDE.
TN2973	3'-O-Methylmurraol
	3'-O-Methylmurraol may have potential anti-inflammatory activity, it exhibits inhibition (IC50 ≤ 7.31 ug/mL) of superoxide anion generation by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB).
TN4388	Kielcorin	Antifection	Microbiology/Virology
	Kielcorin shows antibacterial activity against strain EMRSA-16. It also shows in vitro anti-inflammatory (respiratory burst) inhibiting activities using isolated human neutrophils (IC (50) = 965.21 ± 65.80 uM). trans-Kielcorin has hepatoprotective activity, it can prevent tert-butylhydroperoxide-induced lipid peroxidation and cell death in freshly isolated rat hepatocytes.
TN5227	(+/-)-Vestitol	NOS; CXCR; Antifection	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology
	Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to be applied in the pharmaceutical and food industries. Vestitol inhibits neutrophils migration
TN2767	2'-Hydroxygenistein 鲁冰花	Antifection	Microbiology/Virology
	2'-Hydroxygenistein has antifungal activity, dimerization of it causes a remarkable increase of antifungal activity. It shows significant concentration-dependent inhibitory effects on the release of beta-glucuronidase and lysozyme from rat neutrophils in response to formyl-Met-Leu-Phe/cytochalasin B. 2'-Hydroxygenistein of genistein can enhance its antioxidant activity and cell cytotoxicity in MCF-7 human breast cancer cells.
T79951	Piperkadsin A	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Piperkadsin A作为一种ROS抑制剂，能够有效地抑制PMA诱导的人多形核中性粒细胞中ROS的生成，其IC50值为4.3 μM。
TN3744	Cyclomorusin	NOS; AChR	Immunology/Inflammation; Neuroscience
	Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion generation in fMLP-stimulated rat neutrophils. Cyclomorusin , neocyclomorusin
T38262	Sphingosine (d14:1)
	Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fungus, with an EC50 value of 10.2 nM. Sphingosine (d14:1) inhibits protein kinase C (PKC) in vitro (IC50 = 7.3 mol%) as well as superoxide generation induced by phorbol 12-myristate 13-acetate in neutrophils and reduces growth of CHO cells (IC50s = 19 and 8 μM, respectively).
TN2408	Evofolin B	Cannabinoid Receptor	GPCR/G Protein
	Evofolin B 是从Zanthoxylum ailanthoides 的茎皮中分离出来的天然化合物。Evofolin B 对人类中性粒细胞对甲酰-L-蛋氨酸-L-亮氨酸-L-苯丙氨酸/cytochalasin B（fMLP/CB）产生的超氧阴离子有抑制作用。
T75967	Bactenecin TFA
	Bactenecin TFA (Bactenecin, bovine TFA) 是一种从牛嗜中性粒细胞中分离出来的有效的含 12 个氨基酸的环状抗菌肽。Bactenecin TFA 抑制细菌和酵母菌 (bacteria 和 yeast) 的生长，并能杀死真菌红毛癣菌 (fungusTrichophyton rubrum)。Bactenecin TFA 增加了膜的通透性，抑制了假苹果芽孢杆菌 (B. pseudomallei) 的生长和生物膜的形成。
TN5164	trans-Hinokiresinol	IL Receptor; TNF; NOS; LTR	Apoptosis; Immunology/Inflammation
	Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyasol (cis-hinokiresinol) are estrogen
T36051	Lipoxin A4 脂氧素 A4,LXA4
	Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes.[1] LXA4 is equipotent to leukotriene B4 in inducing superoxide generation in human neutrophils at 0.1 μM.2 LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.[2],[3],[4] Analytical and biological comparisons of synth...
T37291	Lyso-Globotriaosylceramide (d18:1) Lyso-Globotriaosylceramide (d18:1)
	Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas...
TN2766	2'-Hydroxydaidzein	Cannabinoid Receptor; Antioxidant	GPCR/G Protein; oxidation-reduction
	2'-Hydroxydaidzein 是一种在植物中发现的异黄酮类植物素，是一种天然化合物。2'-Hydroxydaidzein 具有抗氧化活性，主要由o -氢键解离焓(BDE)和氢原子转移(HAT)机制驱动。2'-Hydroxydaidzein 抑制炎症细胞中的化学介质，可能对治疗和预防与化学介质产生过多有关的中枢和外周炎症性疾病有作用。2'-Hydroxydaidzein 对大鼠中性粒细胞和formyl-Met-Leu-Phe/cytochalasin B（fMLP/CB）的释放具有抑制作用，IC（50）值分别为2.8+/-0.1和5.9+/-1.4 microM。

天然产物

14-Deoxyandrographolide

Cat.No: T8288

Synonym: 去氧穿心莲内酯,14-去氧穿心莲内酯

Target: Apoptosis, Others

Cat.No: TN1933

Synonym: 帽柱木菲碱,帽柱叶碱

Target: IL Receptor, TNF, NF-κB

4-O-Cinnamoylquinic acid

Cat.No: TN6647

Synonym: 金银花

Target: Prostaglandin Receptor

Tsugaric acid A

Cat.No: TN2286

Target: NO Synthase

Cat.No: T5S1897

Target: Apoptosis, Others, JAK

2,2'-Dihydroxy chalcone

Cat.No: TN7224

Target: Antibacterial, Autophagy

Cat.No: TN3469

Synonym: 2,6-dimethoxy-4-phenylphenol

Target: NADPH-oxidase

3-Chloro-L-Tyrosine

Cat.No: T5280

Synonym: 3-氯-L-酪氨酸,3-Chlorotyrosine,Chlorotyrosine

Target: Others, Endogenous Metabolite

N,N'-Dimethylthiourea

Cat.No: T40615

Synonym: N,N-二甲基硫脲,DMTU

Target: Antioxidant

(-)-Bornyl acetate

Cat.No: TN1448

Synonym: L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯

Target: p38 MAPK, NF-κB, JNK, Antifungal

Antibiotic PF 1052

Cat.No: T38097

Cat.No: TN4317

Target: NADPH-oxidase, cAMP, p38 MAPK, PKA, JNK, PDE

3'-O-Methylmurraol

Cat.No: TN2973

Cat.No: TN4388

Target: Antifection

Cat.No: TN5227

Target: NOS, CXCR, Antifection

2'-Hydroxygenistein

Cat.No: TN2767

Synonym: 鲁冰花

Target: Antifection

Cat.No: T79951

Target: Reactive Oxygen Species

Cat.No: TN3744

Target: NOS, AChR

Sphingosine (d14:1)

Cat.No: T38262

Cat.No: TN2408

Target: Cannabinoid Receptor

Cat.No: T75967

trans-Hinokiresinol

Cat.No: TN5164

Target: IL Receptor, TNF, NOS, LTR

Cat.No: T36051

Synonym: 脂氧素 A4,LXA4

Lyso-Globotriaosylceramide (d18:1)

Cat.No: T37291

Synonym: Lyso-Globotriaosylceramide (d18:1)

2'-Hydroxydaidzein

Cat.No: TN2766

Target: Cannabinoid Receptor, Antioxidant

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