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Search Results for " calmodulin "

94

抑制剂 & 化合物

18

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1271L	Calmodulin-Dependent Protein Kinase II 290-309 acetate Calmodulin-Dependent Protein Kinase II 290-309 acetate (115044-69-4 Free base)	CaMK	Neuroscience
	Calmodulin-Dependent Protein Kinase II 290-309 acetate 是 Ca2+/calmodulin-dependent protein kinase II 的有效拮抗剂（IC50 = 52 nM）。
T40895	Calmodulin antagonist-1
	Calmodulin antagonist-1 (W-7) is a calmodulin (CaM) antagonist that effectively inhibits calmodulin-activated Ca 2+ -phosphodiesterase (PDE) with an IC 50 of 28 μM. This compound also competitively inhibits trypsin-treated Ca 2+ -PDE with respect to cyclic GMP, exhibiting an IC 50 of 375 μM and a K i value of 300 μM.
TP1271	Calmodulin-Dependent Protein Kinase II (290-309) Calmodulin-Dependent Protein Kinase II(290-309)
	Calmodulin-Dependent Protein Kinase II (290-309) is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.
TP1716	Calmodulin-Dependent Protein Kinase II (281-309) Calmodulin-Dependent Protein Kinase II 281-309
	Calmodulin-Dependent Protein Kinase II (281-309) is a synthetic peptide that can be phosphorylated at Thr286 by PKC and inhibits CaM kinase II (IC50 = 80 nM).
TP1710	Calmodulin Binding Peptide 1
	Calmodulin Binding Peptide 1, a potent CaM-binding peptide with picomolar (pM) affinity, originates from smooth muscle myosin light-chain kinase (MLCK peptide). It effectively blocks inositol trisphosphate (IP3)-induced calcium (Ca2+) release [1].
T80549	Calmodulin Kinase IINtide, Myristoylated Myr-CaMKIINtide	CaMK	Neuroscience
	Myristoylated Calmodulin Kinase IINtide（Myr-CaMKIINtide）是一种选择性非竞争性CaMKII抑制剂。
T2697	KN-93	CaMK; Autophagy	Autophagy; Neuroscience
	KN-93是 Ca2+/钙调蛋白依赖性激酶 II (CaMKII) 的选择性抑制剂，Ki 为370 nM，可竞争性阻断 CaM 与激酶的结合。
T14860	CaMKII-IN-1	CaMK; Autophagy	Autophagy; Neuroscience
	CaMKII-IN-1是高效的 CaMKII 选择性抑制剂，IC50为63nM，对 CaMKIV, MLCK, p38a, Akt1,和 PKC 这些靶点几乎无作用。
TP2310	Autocamtide-2-related inhibitory peptide	CaMK; Autophagy	Autophagy; Neuroscience
	Autocamtide-2-related inhibitory peptide 是一种高度特异性和有效的 CaMKII 抑制剂，IC50 为 40 nM。
T6605	NH125	CaMK; Virus Protease; PKA; Antibacterial; PKC; Autophagy; Antifungal	Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Neuroscience; Tyrosine Kinase/Adaptors
	NH125 是一种真核延长因子 2 激酶(eEF-2K/CaMKIII)的高效选择性抑制剂，诱导 eEF2 磷酸化，对 eEF-2K 作用的 IC50值为 60 nM。
T76488	Calmodulin Dependent Protein Kinase Substrate
	CalmodulinDependent Protein Kinase Substrate 为Ca2+及钙调蛋白(CaM)依赖的CaMK底物肽，属合成肽底物类。
TQ0137	A-484954 A 484954	CaMK; Parasite; Autophagy	Autophagy; Microbiology/Virology; Neuroscience
	A-484954 (A 484954) 是一种高度特异性的真核延伸因子-2 抑制剂，其 IC50值为 280 nM。
T14069	A-3 hydrochloride	CaMK; Casein Kinase; PKA; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Neuroscience; Stem Cells; Tyrosine Kinase/Adaptors
	A-3 hydrochloride 是一种细胞可渗透的、可逆的、ATP 竞争性非选择性拮抗剂。它抑制 PKA 、酪蛋白激酶 II 和肌球蛋白轻链激酶，Ki 值分别为4.3 µM、5.1 µM 和7.4 µM。它还抑制 PKC 和酪蛋白激酶 I 的活性，Ki 分别为 47 µM 和 80 µM。
T2694	KN-62	CaMK; P2X Receptor; Autophagy	Autophagy; Membrane transporter/Ion channel; Neuroscience
	KN-62 是一种选择性的、可逆的钙调蛋白依赖性蛋白激酶 II (CaMK-II) 抑制剂，直接与 CaMK-II 酶的钙调蛋白结合位点结合，对大鼠脑 CaMK-II 的IC50值为 0.9 μM。它是非竞争性的P2X7受体拮抗剂，IC50约为 15 nM。
T3546	STO-609 STO 609	CaMK; AMPK; Autophagy	Autophagy; Chromatin/Epigenetic; Neuroscience; PI3K/Akt/mTOR signaling
	STO-609 是一种特异性和细胞渗透性的 Ca2+/钙调蛋白依赖性蛋白激酶激酶抑制剂，用于重组 CaM-KKα 和 CaM-KKβ，Ki 值分别为 80 和 15 ng/mL。它抑制 Hela 细胞溶解物中的 AMP 活化蛋白激酶激酶活性，IC50值约为 0.02 g/ml。
T76487	Calmodulin Dependent Protein Kinase Substrate Analog
	CalmodulinDependent Protein Kinase Substrate Analog 是一种 Ca2+- 和钙调蛋白 (CaM) 依赖性蛋白激酶 (CaMK) 底物肽。CalmodulinDependent Protein Kinase Substrate Analog 是一种合成蛋白激酶的肽底物。
T4185	lavendustin C HDBA,NSC 666251,N-(2,5-二羟基苄基)-5-氨基水杨酸	CaMK; EGFR; Tyrosinase; Src	Angiogenesis; JAK/STAT signaling; Neuroscience; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	lavendustin C (NSC 666251) 是 Ca2+钙调蛋白依赖性激酶 II 抑制剂，IC50为 0.2 µM。它抑制 EGFR 相关酪氨酸激酶和 pp60c-src(+)激酶，IC50分别为 0.012 和 0.5 µM。
T10667	Calmidazolium chloride R 24571,钙调蛋白抑制剂	CaMK; Autophagy	Autophagy; Neuroscience
	Calmidazolium chloride (R 24571) 是一种钙调蛋白拮抗剂，对CaM 依赖性磷酸二酯酶和钙调蛋白诱导的红细胞Ca2+转运ATP 酶活化有拮抗作用，IC50分别为0.15和0.35 μM。Calmidazolium chloride 结合CaMK 的Kd 值为3 nM。Calmidazolium chloride 在抗癌领域有研究的价值。
T75959	Calmodulin-Dependent Protein Kinase II(290-309) acetate
	Calmodulin-Dependent Protein Kinase II (290-309) acetate 是有效的 CaMK 拮抗剂，抑制抑制 Ca2+/钙调蛋白依赖性蛋白激酶II 的IC50值为52 nM。
T8389	Trifluoperazine 三氟拉嗪,trifluoroperazine	CaMK; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; P-gp; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Trifluoperazine (trifluoroperazine) 是一种多巴胺 D2 受体抑制剂，可治疗精神分裂症。它是NUPR1抑制剂，具有抗癌活性。它是α1-adrenergic 受体拮抗剂，是流感病毒形态发生的可逆抑制剂。
T1222	Trifluoperazine dihydrochloride Trifluoperazine 2HCl,盐酸三氟拉嗪,SKF5019,Urinox	CaMK; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; P-gp; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Trifluoperazine dihydrochloride (SKF5019) 是一种抗精神病药物，靶向中枢多巴胺受体。它是流感病毒形态发生的可逆抑制剂，是NUPR1抑制剂，具有抗癌活性。它是钙调蛋白抑制剂，还可抑制 P-糖蛋白，可研究精神分裂症。
T23525	W-9 hydrochloride N-(6-aminohexyl)-5-chloronaphthalene-2-sulfonamide hydrochloride	CaMK	Neuroscience
	W-9 hydrochloride 是一种钙调蛋白拮抗剂。
T20792	W-7 hydrochloride N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐,W 7 HCl,W7 HCl,W-7 HCl	CaMK; Apoptosis; Myosin; PDE	Apoptosis; Cytoskeletal Signaling; Metabolism; Neuroscience
	W-7 hydrochloride (W-7 HCl) 是一种选择性的钙调蛋白拮抗剂。它抑制Ca2+-钙调蛋白依赖性磷酸二酯酶和肌球蛋白轻链激酶，IC50值分别为 28 μM 和 51 μM。它可诱导细胞凋亡，具有抗癌活性。
TP2057L	Camstatin acetate	NO Synthase	Immunology/Inflammation
	Camstatin acetate 结合钙调蛋白并抑制神经元一氧化氮合酶。它是 PEP-19 的单一钙调蛋白结合 IQ 基序的具有功能活性的 25 个残基片段。
TP1910L1	CALP1 acetate CALP1 acetate(145224-99-3 free base)	CaMK	Neuroscience
	CALP1 acetate 是一种钙调蛋白 (CaM) 激动剂（Kd 为 88 µM），可与 CaM EF-hand/Ca2+ 结合位点结合。 CALP1 通过抑制钙通道的开放来阻断钙流入和细胞凋亡（IC50 为 44.78 µM）。 CALP1 阻断谷氨酸受体通道并阻断储存操作的非选择性阳离子通道。 CALP1 激活依赖于 CaM 的磷酸二酯酶活性。
T23522	W-13 hydrochloride W-13 HCl	CaMK	Neuroscience
	W-13 hydrochloride (W-13 HCl) 是一种钙调蛋白拮抗剂。
TP1909L1	CALP2 acetate(261969-04-4 free base)	CaMK; PDE	Metabolism; Neuroscience
	CALP2 acetate 是一种钙调蛋白拮抗剂，对与 CaM EF-hand/Ca2+-结合位点具有高亲和力，Kd 为 7.9 µM。它有效抑制粘附和脱粒。它也是肺泡巨噬细胞的强激活剂。它抑制 CaM 依赖性磷酸二酯酶活性并增加细胞内 Ca2+ 浓度。
T23523	W-5 hydrochloride W-5 HCl,盐酸W-5,W 5 (hydrochloride),N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl	CaMK	Neuroscience
	W-5 hydrochloride (N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl) 一种有效的钙调素拮抗剂。
T22538	A-7 hydrochloride	CaMK	Neuroscience
	A-7 hydrochloride 是一种钙调蛋白拮抗剂，会引起 MDA-MB-231细胞中 CD44+CD24-亚群的改变。
TP1403L	Syntide 2 acetate(108334-68-5 free base)	CaMK	Neuroscience
	Syntide 2 acetate(108334-68-5 free base) 是一种合成肽，被 Ca2+/钙调蛋白依赖性蛋白激酶 II (CaMKII; Km = 12 µM) 识别为底物。
TP1217L	Autocamtide 2 TFA(129198-88-5 free base)	CaMK	Neuroscience
	Autocamtide 2 TFA(129198-88-5 free base) 是钙/钙调蛋白依赖性蛋白激酶 II (CaMKII) 的高选择性肽底物。 Autocamtide 2 TFA 可用于 CaMKII 活性测定。
T68162	Tiflucarbine Tiflucarbina	5-HT Receptor; PDE	GPCR/G Protein; Metabolism; Neuroscience
	Tiflucarbine 是一种潜在的非选择性5-HT激动剂，具有抗抑郁活性。Tiflucarbine 剂量依赖性的增加了大鼠脑中可溶性钙调蛋白（CaM）依赖性磷酸二酯酶的比活性。
TP1911L	CALP3 acetate(261969-05-5 free base)	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	CALP3 acetate(261969-05-5 free base) 是一种有效的 Ca2+ 通道阻滞剂，可激活 Ca2+ 结合蛋白的 EF 手基序。它可以通过调节钙调蛋白 (CaM)、Ca2+ 通道和泵的活性在功能上模拟增加的 [Ca2+]i。
T4530	KN-92 phosphate KN-92 磷酸盐,KN92-H3PO4	CaMK	Neuroscience
	KN-92 phosphate (KN92-H3PO4) 是 KN-93 的非活性衍生物，不能抑制 CaM 激酶活性。它可作为阐明 KN-93 的拮抗活性的对照化合物。KN-93 能够渗透细胞，是一种可逆的 CaMKII 竞争性抑制剂。
T34973	Tyrphostin 8 4-Hydroxybenzylidenemalononitrile	EGFR; GTPase	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrphostin 8(4-Hydroxybenzylidenemalononitrile) 是一种有效的 GTP 酶抑制剂，对 EGFR 激酶有抑制作用， IC50 值为 560 μM。Tyrphostin 8 可抑制蛋白丝氨酸/苏氨酸钙调磷酸酶 (IC50=21 μM)，增强 Caco-2 细胞中转铁蛋白受体介导的转吞作用，并增加口服胰岛素 - 转铁蛋白的降血糖作用。
T8543	KN-92 hydrochloride	CaMK	Neuroscience
	KN-92 hydrochloride 是 KN-93 的非活性衍生物，对 CaM 激酶无抑制作用。它可作为对照化合物用于阐明 KN-93 的拮抗活性。KN-93 是一种可渗透细胞的、可逆的、竞争性的 CaMKII 抑制剂。
T0806	Flunarizine dihydrochloride Flunarizine 2HCl,KW-3149,R14950,盐酸氟桂利嗪	Calcium Channel; Dopamine Receptor; Sodium Channel	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Flunarizine dihydrochloride (R14950) 是 Na+/Ca2+(T 型) 通道双重阻滞剂。它也是 D2多巴胺受体拮抗剂。它具有用于扩张外周血管和预防偏头痛的潜力。
T68064	Elziverine	CaMK	Neuroscience
	Elziverine是一种可口服的小分子钙调蛋白拮抗剂。Elziverine体外处理以浓度依赖性方式抑制了SHRSP，WKY和Wistar大鼠中Ca负载诱导的棘皮细胞形成。Elziverine可用于治疗神经疾病，可用于研究认知障碍。
T2170	SKF-96365 hydrochloride 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑,SKF96365	Apoptosis; Potassium Channel; Calcium Channel; TRP/TRPV Channel; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel; Metabolism
	SKF-96365 hydrochloride (SKF96365) 是store-operated Ca2+entry 抑制剂，也是TRP channel 阻滞剂。它显著抑制豚鼠离体心脏 hERG、hKCNQ1/hKCNE1、hKir2.1 和 hKv4.3 电流，延长QTc 间期。它通过诱导结直肠癌细胞的细胞周期阻滞和凋亡起抗肿瘤作用。
T1158	Phenoxybenzamine hydrochloride 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl	CaMK; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phenoxybenzamine hydrochloride (NCI-c01661) 是一种选择性的 α-adrenoceptor 和 calmodulin 的抑制剂，是常用的抗高血压药。
T17282	Zaldaride maleate CGS-9343B,KW 5617	Others	Others
	Zaldaride maleate inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity (IC50: 3.3 nM). Zaldaride maleate is an effective and selective inhibitor of calmodulin. Zaldaride maleate prevents estrogen-induced transcription activation by ER, re
T23009	MMPX	Others	Others
	calmodulin-sensitive cyclic GMP phosphodiesterase inhibitor
T12021	Metofenazate Methophenazine	Others	Others
	Metofenazate is an selective inhibitor of calmodulin .
T70288	Methophenazine diethanesulfonate
	Methophenazine diethanesulfonate is a Calmodulin antagonist.
T69156	Metofenazate difumarate
	Metofenazate difumarate is a selective calmodulin inhibitor.
T32421	KS 501 KS501,KS-501
	KS 501 interferes with calmodulin activation and is isolated from Sporothrix sp. KAC-1985.
T68201	HT-74
	HT-74 is a calmodulin antagonist.
T71451	Zaldaride (free base)
	Zaldaride (free base) is a calmodulin antagonist.
T25406	Fasciculic acid C
	Fasciculic acid C is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.
T25404	Fasciculic acid A
	Fasciculic acid A is a calmodulin antagonist isolated from mushroom Naematoloma fasciculare.

化合物

Calmodulin-Dependent Protein Kinase II 290-309 acetate

Cat.No: TP1271L

Synonym: Calmodulin-Dependent Protein Kinase II 290-309 acetate (115044-69-4 Free base)

Target: CaMK

Calmodulin antagonist-1

Cat.No: T40895

Calmodulin-Dependent Protein Kinase II (290-309)

Cat.No: TP1271

Synonym: Calmodulin-Dependent Protein Kinase II(290-309)

Calmodulin-Dependent Protein Kinase II (281-309)

Cat.No: TP1716

Synonym: Calmodulin-Dependent Protein Kinase II 281-309

Calmodulin Binding Peptide 1

Cat.No: TP1710

Calmodulin Kinase IINtide, Myristoylated

Cat.No: T80549

Synonym: Myr-CaMKIINtide

Target: CaMK

Cat.No: T2697

Target: CaMK, Autophagy

Cat.No: T14860

Target: CaMK, Autophagy

Autocamtide-2-related inhibitory peptide

Cat.No: TP2310

Target: CaMK, Autophagy

Cat.No: T6605

Target: CaMK, Virus Protease, PKA, Antibacterial, PKC, Autophagy, Antifungal

Calmodulin Dependent Protein Kinase Substrate

Cat.No: T76488

Cat.No: TQ0137

Synonym: A 484954

Target: CaMK, Parasite, Autophagy

A-3 hydrochloride

Cat.No: T14069

Target: CaMK, Casein Kinase, PKA, PKC

Cat.No: T2694

Target: CaMK, P2X Receptor, Autophagy

Cat.No: T3546

Synonym: STO 609

Target: CaMK, AMPK, Autophagy

Calmodulin Dependent Protein Kinase Substrate Analog

Cat.No: T76487

Cat.No: T4185

Synonym: HDBA,NSC 666251,N-(2,5-二羟基苄基)-5-氨基水杨酸

Target: CaMK, EGFR, Tyrosinase, Src

Calmidazolium chloride

Cat.No: T10667

Synonym: R 24571,钙调蛋白抑制剂

Target: CaMK, Autophagy

Calmodulin-Dependent Protein Kinase II(290-309) acetate

Cat.No: T75959

Trifluoperazine

Cat.No: T8389

Synonym: 三氟拉嗪,trifluoroperazine

Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy

Trifluoperazine dihydrochloride

Cat.No: T1222

Synonym: Trifluoperazine 2HCl,盐酸三氟拉嗪,SKF5019,Urinox

Target: CaMK, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, P-gp, Autophagy

W-9 hydrochloride

Cat.No: T23525

Synonym: N-(6-aminohexyl)-5-chloronaphthalene-2-sulfonamide hydrochloride

Target: CaMK

W-7 hydrochloride

Cat.No: T20792

Synonym: N-(6-氨基己基)-5-氯-1-萘磺胺盐酸盐,W 7 HCl,W7 HCl,W-7 HCl

Target: CaMK, Apoptosis, Myosin, PDE

Camstatin acetate

Cat.No: TP2057L

Target: NO Synthase

Cat.No: TP1910L1

Synonym: CALP1 acetate(145224-99-3 free base)

Target: CaMK

W-13 hydrochloride

Cat.No: T23522

Synonym: W-13 HCl

Target: CaMK

CALP2 acetate(261969-04-4 free base)

Cat.No: TP1909L1

Target: CaMK, PDE

W-5 hydrochloride

Cat.No: T23523

Synonym: W-5 HCl,盐酸W-5,W 5 (hydrochloride),N-(6-Aminohexyl)-1-naphthalenesulfonamide HCl

Target: CaMK

A-7 hydrochloride

Cat.No: T22538

Target: CaMK

Syntide 2 acetate(108334-68-5 free base)

Cat.No: TP1403L

Target: CaMK

Autocamtide 2 TFA(129198-88-5 free base)

Cat.No: TP1217L

Target: CaMK

Cat.No: T68162

Synonym: Tiflucarbina

Target: 5-HT Receptor, PDE

CALP3 acetate(261969-05-5 free base)

Cat.No: TP1911L

Target: Calcium Channel

KN-92 phosphate

Cat.No: T4530

Synonym: KN-92 磷酸盐,KN92-H3PO4

Target: CaMK

Cat.No: T34973

Synonym: 4-Hydroxybenzylidenemalononitrile

Target: EGFR, GTPase

KN-92 hydrochloride

Cat.No: T8543

Target: CaMK

Flunarizine dihydrochloride

Cat.No: T0806

Synonym: Flunarizine 2HCl,KW-3149,R14950,盐酸氟桂利嗪

Target: Calcium Channel, Dopamine Receptor, Sodium Channel

Cat.No: T68064

Target: CaMK

SKF-96365 hydrochloride

Cat.No: T2170

Synonym: 1-[2-(4-甲氧基)-2-[3-(4-甲氧基苯基)丙氧基]乙基]咪唑,SKF96365

Target: Apoptosis, Potassium Channel, Calcium Channel, TRP/TRPV Channel, Autophagy

Phenoxybenzamine hydrochloride

Cat.No: T1158

Synonym: 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl

Target: CaMK, Adrenergic Receptor

Zaldaride maleate

Cat.No: T17282

Synonym: CGS-9343B,KW 5617

Target: Others

Cat.No: T23009

Target: Others

Cat.No: T12021

Synonym: Methophenazine

Target: Others

Methophenazine diethanesulfonate

Cat.No: T70288

Metofenazate difumarate

Cat.No: T69156

Cat.No: T32421

Synonym: KS501,KS-501

Cat.No: T68201

Zaldaride (free base)

Cat.No: T71451

Fasciculic acid C

Cat.No: T25406

Fasciculic acid A

Cat.No: T25404

Cat. No.	Product Name	Target	Signaling Pathways
TN1008	Psoralenoside	CaMK; Calcium Channel; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Psoralenoside 是源于补骨脂中的苯并呋喃苷，具有抗肿瘤、抗菌、促进成骨细胞增殖和雌激素样活性。它对组胺 H1、钙调素和电压门控 l 型钙通道具有较高的亲和力。
T3777	Praeruptorin A (+)-Praeruptorin A,白花前胡甲素	CaMK; NF-κB	Neuroscience; NF-κB
	Praeruptorin A ((+)-Praeruptorin A) 是一种白花前胡的主要生物活性成分。它能够抑制 NF-κB 活化，发挥抗炎作用。
T4S1419	(±)-Praeruptorin A Praeruptorin A,(±)-白花前胡甲素,白花前胡甲素,(-)-Praeruptorin A	p38 MAPK; Calcium Channel; Akt	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	(±)-Praeruptorin A 是来自白花前胡的干燥根中的一种主要成分，用于研究伴有厚痰和呼吸困难的咳嗽，非天生性咳嗽和上呼吸道感染。它是顺式-内酯 (CKL) 的二酯化产物，可作为 Ca2+-反流阻滞剂，用于高血压的研究。
T2144	Tacrolimus 他克莫司,Fujimycin,FK506,FR900506	Phosphatase; Others; Antibacterial; Antibiotic; mTOR; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling
	Tacrolimus (Fujimycin) 可与 FKBP12 结合形成高亲和力复合物 (Ki: 0.2 nM)，抑制钙/钙调蛋白依赖性蛋白磷酸酶的活性。
T3904	Gomisin J	Calcium Channel; AMPK	Chromatin/Epigenetic; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Gomisin J 是在五味子中发现的小分子量木脂素，具有血管舒张活性，在非酒精性脂肪性肝病方面有研究潜力。它通过激活 AMPK、LKB1 和 Ca2+/钙调蛋白依赖性蛋白激酶 II 以及抑制 HepG2 细胞中的胎球蛋白 A 来调节脂肪生成酶和脂肪分解酶以及炎症分子的表达，从而抑制脂质积累。
T4839	Ac-Ala-OH N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
T16397	Ophiobolin A	Others	Others
	Ophiobolin A is a fungal metabolite and a phytotoxin and is an effective and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase (IC50: 9 μM). Ophiobolin A also has antimicrobial and anticancer activity.
T82472	Encecalinol
	Encecalinol，一种从Ageratina grandifolia地上部分提取的化合物，有效地抑制钙调蛋白（calmodulin）。
T70221	Dibefurin
	Dibefurin is a metabolite that inhibits the activity of calcineurin, a calcium/calmodulin-dependent protein phosphatase involved in the activation of T lymphocytes.
T72902	Acremonidin A
	Acremonidin A 是一种有效的钙调素(CaM)抑制剂，存在于Purpureocillium lilacinum 中。Acremonidin A 与人钙调素 (hCaM) 生物传感器 hCaM M124C mBBr 结合，Kd 为 19.40 nM。
T72731	Acremoxanthone C
	Acremoxantone C 是一种有效的钙调素(CaM)抑制剂，存在于 Purpureocillium lilacinum 中。Acremoxantone C 与人钙调素 (hCaM) 生物传感器 hCaM M124C mBBr 结合，Kd 为 18.25 nM。
T15636	K-252a Antibiotic K 252a,Antibiotic SF 2370,SF2370	Others	Others
	K-252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi. K-252a inhibits protein kinase (IC50: 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively).
TN4551	Methyl orsellinate	Phosphatase; cAMP; Antifection	GPCR/G Protein; Metabolism; Microbiology/Virology
	Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interact with bovine-brain calmodulin and inhibit the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase. Methyl orsellinate can inhibit PTP1B activity with 50% inhibitory concentration values of 277 +/- 8.6 microM, the selective inhibition of PTP1B has been widely recognized as a potential ...
T83518	(S)-O-Methylencecalinol
	(S)-O-Methylencecalinol (compound 10)，一种从Ageratina grandfolia地上部分分离得到的化合物，目标是钙调素。
T83367	3,5-Diprenyl-4-hydroxyacetophenone
	3,5-Diprenyl-4-hydroxyacetophenone（化合物8）是从桔梗地上部分分离出的化合物，具有钙调素靶向性。
T74198	Beauverolide Ja
	Beauverolide Ja 是一种环四缩酚肽，是一种有效的钙调蛋白 (CaM) 抑制剂，对 Ca2+-CaM 的Kd 为 0.078 μM，Ki 为 0.39 μM。Beauverolide Ja 是Isaria fumosorosea 的次级代谢产物。
TN1834	Kobusin 去甲槟郎碱,自旋七叶素	Others; NOS; NF-κB	Immunology/Inflammation; NF-κB; Others
	Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Kobusin can mildly reduce gastrointestinal motility in mice, it activates CFTR and CaCCgie chloride channel activities in mouse colonic epithelia and shows inhibitory effects toward ANO1/CaCC-mediated short-circuit currents in ANO1/CaCC-express...

天然产物

Cat.No: TN1008

Target: CaMK, Calcium Channel, Histamine Receptor

Cat.No: T3777

Synonym: (+)-Praeruptorin A,白花前胡甲素

Target: CaMK, NF-κB

(±)-Praeruptorin A

Cat.No: T4S1419

Synonym: Praeruptorin A,(±)-白花前胡甲素,白花前胡甲素,(-)-Praeruptorin A

Target: p38 MAPK, Calcium Channel, Akt

Cat.No: T2144

Synonym: 他克莫司,Fujimycin,FK506,FR900506

Target: Phosphatase, Others, Antibacterial, Antibiotic, mTOR, Autophagy

Cat.No: T3904

Target: Calcium Channel, AMPK

Cat.No: T4839

Synonym: N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸

Target: Others, Endogenous Metabolite

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

Cat.No: T16397

Target: Others

Cat.No: T82472

Cat.No: T70221

Cat.No: T72902

Acremoxanthone C

Cat.No: T72731

Cat.No: T15636

Synonym: Antibiotic K 252a,Antibiotic SF 2370,SF2370

Target: Others

Methyl orsellinate

Cat.No: TN4551

Target: Phosphatase, cAMP, Antifection

(S)-O-Methylencecalinol

Cat.No: T83518

3,5-Diprenyl-4-hydroxyacetophenone

Cat.No: T83367

Beauverolide Ja

Cat.No: T74198

Cat.No: TN1834

Synonym: 去甲槟郎碱,自旋七叶素

Target: Others, NOS, NF-κB

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