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Search Results for " antimalarial "

154

抑制剂 & 化合物

62

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10336	Antimalarial agent 1	Parasite	Microbiology/Virology
	Antimalarial agent 1 是一种抗疟药。
T9984	Antimalarial agent 13 N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine	Parasite	Microbiology/Virology
	Antimalarial agent 13 (N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine) 是一种有效的抗疟剂。
T22381	Antimalarial agent 14 4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone	Others	Others
	Antimalarial agent 14 (NSC-102533) 是一种生物活性化学品。
T79535	Antimalarial agent 30	Parasite	Microbiology/Virology
	Antimalarial agent 30 具有抗伯氏疟原虫肝期寄生虫活性和抗疟活性，可用于研究疟感染。
T75067	Antimalarial agent 19	Parasite	Microbiology/Virology
	Antimalarial agent 19（compound 6e）是一种活性抗疟疾化合物，对K1型恶性疟原虫和伯氏疟原虫展现出较强的抑制效果，其EC50值分别为0.3 µM和15.3 µM。相较于γ-肝硫平，该化合物具有更好的水溶性、肠道渗透性以及微粒体稳定性。
T72416	Antimalarial agent 18
	Antimalarial agent 18 是一种有效抗疟剂，展现出电子、亲脂性和铁疏性特质。该化合物隶属于酰氧基甲基系列，可视为磷霉素的替代品，后者是针对非甲羟戊酸类异戊二烯生物合成途径的有效IspC抑制剂。Antimalarial agent 18 对恶性疟原虫和鲍曼疟原虫的生长抑制作用显著，其IC50值分别为50 nM和390 nM。
T63043	Antimalarial agent 2
	Antimalarial agent 2 是一种具有口服活性的、新型的抗疟药，在体外表现出快速的杀灭效果。
T62936	Antimalarial agent 8
	Antimalarial agent 8 (Compound 7e) 是一种新型的、口服具有活力的抗疟药。Antimalarial agent 8 在体外能够有效作用于 P. falciparum，且在体内疟疾小鼠模型中口服有效 (40 mg/kg)。
T78952	Antimalarial agent 26	Parasite	Microbiology/Virology
	Antimalarial agent 26是一种1,4-萘醌衍生物，作为口服抗疟药物，对恶性疟原虫(P. falciparum)表现出细胞毒性，并具有优于哺乳动物细胞系的选择性。该化合物能够有效抑制体内P. berghei引起的寄生虫血症。
T79335	Antimalarial agent 31	Parasite	Microbiology/Virology
	Antimalarial agent 31 (compound 7k) 是抗恶性疟疾的口服活性抑制剂，针对恶性疟原虫天冬氨酸蛋白酶血浆蛋白酶 X (PMX)。
T61200	Antimalarial agent 3
	Antimalarial agent 3, an antimalarial agent, exhibits potent activity against Plasmodium with an IC50 of 0.035 μM. Furthermore, it demonstrates an exceptionally high selectivity index in relation to mammalian cells.
T63052	Antimalarial agent 10
	Antimalarial agent 10 (Compound 17b) 是一种氨基醇喹啉化合物。Antimalarial agent 10 也是一种抗疟药，能够作用于 Pf3D7 (IC50: 14.9 nM) 和 PfW2 (IC50: 11 nM)，无论哪种细胞系，其选择性指数均大于 770。
T62537	Antimalarial agent 7
	Antimalarial agent 7 是一种有效的 PfATP4 的有效抑制剂。其中 PfATP4 是一种寄生虫表面必不可少的离子泵。Antimalarial agent 7 具有潜力进行人类疟原虫 Plasmodium falciparum 的研究。
T72396	Antimalarial agent 20
	Antimalarial agent 20 是一种抗疟剂，在 NF54 蛋白测定中对P. falciparumNF54 寄生菌株的IC50为 0.6 nM。
T78936	Antimalarial agent 27	Parasite	Microbiology/Virology
	Antimalarial agent 27 (compound 11a) 是一款针对恶性疟原虫有效的抗疟疾化合物，展现出优异的抑制能力（IC50=0.37 μM）。其机制主要通过抑制目标疟原虫中的DXR (1-脱氧-D-木糖-5-磷酸还原酶)，以达成较高抑制效果（IC50=0.11 μM）。
T62300	Antimalarial agent 11
	Antimalarial agent 11 (compound 1) 一种有效的抗疟 (antimalarial) 剂，是一种螺环色烷。Antimalarial agent 11 具有良好的抗氯喹 Dd2 菌株的效果 (EC50: 350 nM)。Antimalarial agent 11 能够作用于 D6 (EC50: 1.48 μM) 和 ARC08-022 (EC50: 1.81 μM) 。
T63456	Antimalarial agent 12
	Antimalarial agent 12 是有效的抗疟 (antimalarial) 药，能够抑制恶性疟原虫 Dd2 菌株、3D7 菌株生长，其 EC50值分别为155 nM、136 nM。Antimalarial agent 12 对大肠杆菌的 MIC>250,000 nM，也能够作用于 HEK-293 和 hPHep 细胞系，其 CC50值为 10,000-50,000 nM。
T63595	Antimalarial agent 16
	Antimalarial agent 16 是 parasite 抑制剂，表现出抗疟效果，对恶性疟原虫的生长具有抑制作用，其 IC50值为2.0 nM。
T74695	Antimalarial agent 17
	Antimalarial agent 17，一种兼具抗疟和除草功能的化合物，作为光系统 II 型抑制剂，在出苗后除草活性方面与市售除草剂表现出相当的效力。
T74845	Antimalarial agent 23
	Antimalarial agent 23，一种苯并咪唑抗疟药，对PfNF54和PfK1的IC50值均显示出良好的活性，分别为0.08 μM和0.10 μM。该化合物展现了有效的β-血红素抑制活性，但并不直接抑制血红素向疟原虫色素的转化。
T63655	Antimalarial agent 9
	Antimalarial agent 9 是有效的抗疟药，是一种喹啉-咪唑衍生物化合物。Antimalarial agent 9 在体外对 CQ 敏感株(IC50-0.14 μM)和 MDR 株(IC50-0.41 μM) 均显示出明显的抗疟效果，具有较小的细胞毒性和高度的选择性。
T63413	Antimalarial agent 15
	Antimalarial agent 15 是 parasite 抑制剂，表现出抗疟作用，对恶性疟原虫 3D7 的生长具有抑制作用，其 IC50值为20 nM。
T78951	Antimalarial agent 24	Parasite	Microbiology/Virology
	Antimalarial agent 24（Compound 7）是一种抗疟化合物，具有显著的体外（in vitro）活性。针对P. falciparum W2菌株，其IC50值为0.81 μM。同时，Antimalarial agent 24展现在HepG2细胞上的CC50值高于200 μM，表明其对宿主细胞具有较高安全性。
T79534	Antimalarial agent 29	Parasite	Microbiology/Virology
	Antimalarial agent 29 (compound 16) 作为一种效力较高的抗疟化合物，其针对伯氏疟原虫肝期寄生虫的EC500值达到5.2 μM。
T83044	Antimalarial agent 33	Parasite	Microbiology/Virology
	Antimalarial agent 33 (compound 5g) 显示针对红细胞期和肝期疟原虫的抗活性，特别是对 K1 恶性疟原虫株，其EC50为1.1 μM。Antimalarial agent 33 还展示出提升的微粒体稳定性（T1/2=29分钟），并且对原代肝细胞未表现出明显的细胞毒效应。
T79460	Antimalarial agent 28	Parasite	Microbiology/Virology
	Antimalarial agent 28 (Compound 2i)为具有针对P. berghei三个发育阶段活性的化合物。该化合物的IC50s针对肝期P. berghei为0.561 μM，对早期配子体为0.14 μM，以及对环期P. berghei为4.34 μM，表明其具有抑制该寄生虫的潜力。
T9741	INE963	Others	Others
	INE963 是快速有效的血液阶段抗疟剂，EC50为 3-6 nM。INE963 有单纯性疟疾的研究潜力。
T5477	ELQ-300	Parasite	Microbiology/Virology
	ELQ-300 是一种有口服生物活性的抗疟疾剂，可作为细胞色素 bc1 复合物的还原位点的抑制剂
T8381	Amodiaquine	Others; Histone Methyltransferase; Parasite	Chromatin/Epigenetic; Microbiology/Virology; Others
	Amodiaquine 是一种合成的4-氨基喹啉类抗疟剂，是一种有口服活性的组胺 N-甲基转移酶抑制剂。它也是一种Nurr1激动剂，有抗炎活性，可特异性结合Nurr1的配体结合域，EC50约为20 μM。
T4382	Proguanil hydrochloride Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil	Others; Dehydrogenase; DNA/RNA Synthesis; Antifolate; Parasite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Others
	Proguanil hydrochloride (Chloroquanil) 是一种双胍类抗疟疾剂，在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。
T6992	Sulfadiazine sodium Sulfadiazin-natrium,磺胺嘧啶钠,Sodium sulfadiazine	Others; Antibacterial; Antibiotic; Parasite	Microbiology/Virology; Others
	Sulfadiazine sodium (Sulfadiazin-natrium) 是一种磺胺类抗生素具有抗疟活性，可研究弓形虫病。
T40417	Ethylhydrocupreine hydrochloride Optochin hydrochloride,乙氢去甲奎宁盐酸盐；奥普托欣盐酸盐	Antibacterial; Parasite	Microbiology/Virology
	Ethylhydrocupreine hydrochloride (Optochin hydrochloride) 是奎宁的一种衍生物，具有抗菌作用，可抑制肺炎链球菌的活性。Ethylhydrocupreine hydrochloride 具有抗疟活性，对 Plasmodium falciparum 的IC50为 25.75 nM。Ethylhydrocupreine hydrochloride 是Gallus gallus2 受体 (ggTas2r1，ggTas2r2和ggTas2r7) 激动剂。
T0849	Pyrimethamine Pirimecidan,RP 4753,Pirimetamin,乙胺嘧啶	DHFR; Antifolate; Parasite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Pyrimethamine (Pirimecidan) 是一种二氢叶酸还原酶的竞争性抑制剂，用作抗疟药。
T11558	Hexyl gallate 没食子酸己酯,Gallic acid hexyl ester,Hexyl 3,4,5-trihydroxybenzoate	Antibacterial	Microbiology/Virology
	Hexyl gallate (Gallic acid hexyl ester) 是没食子酸的烷基酯衍生物，对恶性疟原虫具有很强的抗疟活性，IC50为 0.11 mM。它具有抗菌活性，通过抑制 RhlR 抑制鼠李糖脂和绿脓杆菌素的产生。
T0860	Mefloquine hydrochloride Mefloquin hydrochloride,Mefloquine HCl,盐酸甲氟喹	Potassium Channel; SARS-CoV; Reactive Oxygen Species; Parasite; Autophagy	Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; NF-κB
	Mefloquine hydrochloride (Mefloquin hydrochloride) 是喹啉抗疟药，是抗 SARS-CoV-2进入抑制剂，可研究疟疾、系统性红斑狼疮和癌症。它也是 K+通道(KvQT1/minK) 拮抗剂，IC50约为 1 μM。
T7744	Piperaquine tetraphosphate tetrahydrate 4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物,四磷酸哌喹四水合物	Parasite	Microbiology/Virology
	Piperaquine tetraphosphate tetrahydrate 是一种双喹啉抗寄生虫剂，可与青蒿素联用研究抗疟。
T0381	Amodiaquine dihydrochloride dihydrate Amodiaquine hydrochloride,阿莫地喹盐酸盐,Amodiaquin dihydrochloride dihydrate	Histone Methyltransferase; Parasite; Histamine Receptor	Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) 是一种具有口服活性的组胺 N-甲基转移酶抑制剂，也是一种Nurr1激动剂，可特异性结合Nurr1的配体结合域，EC50约为20 μM。它是 4-氨基喹啉衍生物，具有抗疟和抗炎特性。
T0860L	Mefloquine Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998	Others	Others
	Mefloquine (Ro 215998) 是一种喹啉抗疟药，是一种抗 SARS-CoV-2 进入抑制剂。 Mefloquine 也是一种 K+ 通道 (KvQT1/minK) 拮抗剂，IC50 为 ~1 μM。它可用于疟疾、系统性红斑狼疮和癌症研究。
T7532	Piperaquine	Parasite	Microbiology/Virology
	Piperaquine 是一种双喹啉化合物，可抑制来自疟疾感染患者的恶性疟原虫分离株的离体生长，IC50 范围为 11.8-217.3 nM。
T6888	Methylene Blue 亚甲蓝,methylthioninium chloride,CI-52015,Tetramethylthionine chloride,亚甲兰,Basic Blue 9	Guanylate cyclase; Microtubule Associated; NO Synthase; Parasite; Monoamine Oxidase	Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Methylene Blue (Tetramethylthionine chloride) 是鸟苷酸环化酶，是单胺氧化酶 A 和 NO 合酶抑制剂。它有抗伤害感受、抗疟疾、抗抑郁和抗焦虑作用，可研究高铁血红蛋白血症、神经退行性疾病和异环磷酰胺引起的脑病。它是血管加压剂，用作色素内窥镜检查中的染料。
T0006	Methylene Blue trihydrate 碱性亚甲蓝三水合物,Methylthionine chloride,Basic blue 9,亚甲蓝三水合物,Methylene Blue	Guanylate cyclase; Microtubule Associated; NO Synthase; Parasite; Monoamine Oxidase	Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Methylene Blue trihydrate (Basic blue 9) 是鸟苷酸环化酶，单胺氧化酶 A 和 NO 合酶抑制剂。它是血管加压药，在医疗中通常用作染料。它具有抗伤害感受，抗疟疾，抗抑郁和抗焦虑作用，可用于高铁血红蛋白血症，神经退行性疾病和异环磷酰胺引起的脑病的研究。
T20102	8-Azahypoxanthine NSC 22709,NSC-22709,阿扎次黄嘌呤,NSC22709	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	8-Azahypoxanthine (NSC-22709) 抑制次黄嘌呤-鸟嘌呤-黄嘌呤磷酸核糖基转移酶并具有抗疟特性。
T10378	Artelinic acid	Others	Others
	Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug-resistant strains of Plasmodium falciparum.
T67695	MMV688533	Parasite	Microbiology/Virology
	MMV688533具有抗疟活性。
T17313	(+)-SJ733 SJ000557733	ATPase; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	(+)-SJ733 (SJ000557733) 是一种有效的 Na+-ATPase PfATP4 抑制剂，具有抗疟活性，可用于研究疟疾。
T0519	Euquinine Quinine ethylcarbonate,无味奎宁	Others	Others
	Euquinine (Quinine ethylcarbonate) 通常用作退热药、抗疟药和补品。
T9591	YCN47284	Parasite	Microbiology/Virology
	YCN47284 是一种抗疟化合物，对恶性疟原虫的 IC50 为 1 μM。
T10356	AQ-13 dihydrochloride	Parasite	Microbiology/Virology
	AQ-13 dihydrochloride 是一种氨基喹啉类抗疟药，对耐药型菌株 Plasmodium falciparum 有抑制作用。
T67880	NITD-609 Enantiomer	Others	Others
	NITD-609 Enantiomer 是 NITD-609 的对映体，NITD-609 是一种具有抗疟活性的螺酮类药物。
T16326	Cipargamin KAE609,NITD609	Parasite	Microbiology/Virology
	Cipargamin (NITD609) 是一种有效的抗疟药物，对恶性疟原虫的IC50值约为 1 nM。

化合物

Antimalarial agent 1

Cat.No: T10336

Target: Parasite

Antimalarial agent 13

Cat.No: T9984

Synonym: N2-(3-chlorophenyl)-N4-(furan-2-ylmethyl)quinazoline-2,4-diamine

Target: Parasite

Antimalarial agent 14

Cat.No: T22381

Synonym: 4-hydroxy-3-phenyl-naphthalene-1,2-dione,2-Hydroxy-3-phenyl-1,4-naphthoquinone

Target: Others

Antimalarial agent 30

Cat.No: T79535

Target: Parasite

Antimalarial agent 19

Cat.No: T75067

Target: Parasite

Antimalarial agent 18

Cat.No: T72416

Antimalarial agent 2

Cat.No: T63043

Antimalarial agent 8

Cat.No: T62936

Antimalarial agent 26

Cat.No: T78952

Target: Parasite

Antimalarial agent 31

Cat.No: T79335

Target: Parasite

Antimalarial agent 3

Cat.No: T61200

Antimalarial agent 10

Cat.No: T63052

Antimalarial agent 7

Cat.No: T62537

Antimalarial agent 20

Cat.No: T72396

Antimalarial agent 27

Cat.No: T78936

Target: Parasite

Antimalarial agent 11

Cat.No: T62300

Antimalarial agent 12

Cat.No: T63456

Antimalarial agent 16

Cat.No: T63595

Antimalarial agent 17

Cat.No: T74695

Antimalarial agent 23

Cat.No: T74845

Antimalarial agent 9

Cat.No: T63655

Antimalarial agent 15

Cat.No: T63413

Antimalarial agent 24

Cat.No: T78951

Target: Parasite

Antimalarial agent 29

Cat.No: T79534

Target: Parasite

Antimalarial agent 33

Cat.No: T83044

Target: Parasite

Antimalarial agent 28

Cat.No: T79460

Target: Parasite

Cat.No: T9741

Target: Others

Cat.No: T5477

Target: Parasite

Cat.No: T8381

Target: Others, Histone Methyltransferase, Parasite

Proguanil hydrochloride

Cat.No: T4382

Synonym: Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil

Target: Others, Dehydrogenase, DNA/RNA Synthesis, Antifolate, Parasite

Sulfadiazine sodium

Cat.No: T6992

Synonym: Sulfadiazin-natrium,磺胺嘧啶钠,Sodium sulfadiazine

Target: Others, Antibacterial, Antibiotic, Parasite

Ethylhydrocupreine hydrochloride

Cat.No: T40417

Synonym: Optochin hydrochloride,乙氢去甲奎宁盐酸盐；奥普托欣盐酸盐

Target: Antibacterial, Parasite

Cat.No: T0849

Synonym: Pirimecidan,RP 4753,Pirimetamin,乙胺嘧啶

Target: DHFR, Antifolate, Parasite

Cat.No: T11558

Synonym: 没食子酸己酯,Gallic acid hexyl ester,Hexyl 3,4,5-trihydroxybenzoate

Target: Antibacterial

Mefloquine hydrochloride

Cat.No: T0860

Synonym: Mefloquin hydrochloride,Mefloquine HCl,盐酸甲氟喹

Target: Potassium Channel, SARS-CoV, Reactive Oxygen Species, Parasite, Autophagy

Piperaquine tetraphosphate tetrahydrate

Cat.No: T7744

Synonym: 4,4'-(1,3-丙烷双-4,1-哌嗪基)双(7-氯喹啉)磷酸盐水合物,四磷酸哌喹四水合物

Target: Parasite

Amodiaquine dihydrochloride dihydrate

Cat.No: T0381

Synonym: Amodiaquine hydrochloride,阿莫地喹盐酸盐,Amodiaquin dihydrochloride dihydrate

Target: Histone Methyltransferase, Parasite, Histamine Receptor

Cat.No: T0860L

Synonym: Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998

Target: Others

Cat.No: T7532

Target: Parasite

Cat.No: T6888

Synonym: 亚甲蓝,methylthioninium chloride,CI-52015,Tetramethylthionine chloride,亚甲兰,Basic Blue 9

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

Methylene Blue trihydrate

Cat.No: T0006

Synonym: 碱性亚甲蓝三水合物,Methylthionine chloride,Basic blue 9,亚甲蓝三水合物,Methylene Blue

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

8-Azahypoxanthine

Cat.No: T20102

Synonym: NSC 22709,NSC-22709,阿扎次黄嘌呤,NSC22709

Target: Nucleoside Antimetabolite/Analog

Cat.No: T10378

Target: Others

Cat.No: T67695

Target: Parasite

Cat.No: T17313

Synonym: SJ000557733

Target: ATPase, Parasite

Cat.No: T0519

Synonym: Quinine ethylcarbonate,无味奎宁

Target: Others

Cat.No: T9591

Target: Parasite

AQ-13 dihydrochloride

Cat.No: T10356

Target: Parasite

NITD-609 Enantiomer

Cat.No: T67880

Target: Others

Cat.No: T16326

Synonym: KAE609,NITD609

Target: Parasite

Cat. No.	Product Name	Target	Signaling Pathways
T6S0084	Tuberostemonine 对叶百部碱,Tuberstemonine	Parasite	Microbiology/Virology
	Tuberostemonine (Tuberstemonine) 是一种生物碱，可作为抗疟疾剂，有较高的肠道通透性。
T10835	Cletoquine Desethylhydroxychloroquine	Parasite; Antifection	Microbiology/Virology
	Cletoquine 是 Hydroxychloroquine 的主要活性代谢物。 Cletoquine 具有对抗基孔肯雅病毒 (CHIKV) 的能力。 Cletoquine 具有抗疟作用，并具有治疗自身免疫性疾病的潜力。
TN2027	Oxysanguinarine 8-Oxosanguinarine,氧化血根碱,Hydroxysanguinarine	Parasite	Microbiology/Virology
	Oxysanguinarine (Hydroxysanguinarine) 是一种来自Meconopsis simplicifolia 的小檗生物碱，具有抗疟和抗血小板聚集活性，对登革热病毒具有潜在的抑制作用。
TN1019	Beta-mangostin β-Mangostin,beta-倒捻子素	Apoptosis; Antibacterial; Parasite	Apoptosis; Microbiology/Virology
	Beta-mangostin (β-Mangostin) 是存在 Cratoxylum arborescens 中的一种氧杂蒽酮类天然产物，有抗癌和抗菌活性，对结核分枝杆菌的 MIC 值为 6.25 μg/mL。它在体外有抗疟活性，对恶性疟原虫的 IC50值为 3.00 μg/mL。
TN1012	Febrifugine	IL Receptor; Anti-infection; Parasite	Immunology/Inflammation; Microbiology/Virology
	Febrifugine 是存在于常山的根和叶中的一种喹唑啉酮类生物碱，有抗疟活性。它是一种有效的抗球虫药，具有杀灭裂殖体的作用。
TN1012L	Febrifugine dihydrochloride ISF-2123,Propyldazine hydrochloride,Atensil,(+)-Febrifugine dihydrochloride,常山乙素二盐酸盐,Pildralazine dihydrochloride	Parasite	Microbiology/Virology
	Febrifugine dihydrochloride (Propyldazine hydrochloride) 是存在于常山的根和叶中的一种喹唑啉酮类生物碱，具有治疗疟疾、癌症、纤维化和炎症性疾病的活性。
T3324	Lycorine Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱	Apoptosis; Virus Protease; Antibacterial; AChR; Fatty Acid Synthase	Apoptosis; Metabolism; Microbiology/Virology; Neuroscience
	Lycorine (Narcissine) 是从金眼科植物科中提取的一种天然生物碱。它是一种具有口服活性的SCAP 抑制剂，Kd 值 15.24 nM。它也是黑色素瘤血管生成抑制剂，有用于前列腺癌和代谢疾病的研究潜力。
T7059	α-Dihydroartemisinin α-Artenimol,α-Dihydroqinghaosu	Parasite	Microbiology/Virology
	α-Dihydroartemisinin (α-Dihydroqinghaosu) 是青蒿素类抗疟化合物的中间体，具有良好的抗疟抗癌活性，可用于研究红斑狼疮。
TN1145	Isofebrifugine	Parasite	Microbiology/Virology
	Isofebrifugine 是一种来自虎耳草科植物常山的生物碱，具有抗疟抗感染活性。
T3S1447	Arteannuin B	SARS-CoV; Ferroptosis	Apoptosis; Microbiology/Virology
	Arteannuin B 与青蒿素共同存在，有强效抗疟活性，具有抗 SARS-CoV-2 的活性，EC50为 10.28 μM。
T1323	Artemether SM224,蒿甲醚,Dihydroartemisinin methyl ether,Dihydroqinghaosu methyl ether,CGP 56696	Antibiotic; Parasite	Microbiology/Virology
	Artemether (CGP 56696) 是一种用于治疗急性单纯性疟疾的抗疟药。
T25114	Ascaridole NSC-406266,NSC 406266,NSC406266	Parasite	Microbiology/Virology
	Ascaridole (NSC-406266) 可作为驱虫化合物，能驱除人体和植物中的寄生蠕虫(蠕虫)，具有较弱的抗疟活性。
T3327	Artemotil SM-227,β-Arteether,Beta-Arteether,蒿乙醚,Arteether,(+)-Arteether	CXCR; CCR; Parasite	Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology
	Artemotil (SM-227) 是一种新型的速效抗疟药，可研究耐Plasmodium falciparum 的恶性疟原虫疟疾，IC50值为 1.61 nM。
T4333	Quinine dihydrochloride 盐酸奎宁,Quinine bimuriate	Others	Others
	Quinine dihydrochloride (Quinine bimuriate) 是Cinchona(Rubiaceae) 各种物种的主要生物碱。它也是一种抗疟药和肌肉松弛剂（骨骼）。
T7938	Quinidine 奎尼丁,奎宁树	Parasite	Microbiology/Virology
	Quinidine 是一种抗心律失常剂，也是 K+通道的有效阻断剂，其 IC50值为 19.9 μM。它是一种选择性细胞色素 P450db 的有效抑制剂，也可研究疟疾。
T8859	NITIDINE	Others	Others
	NITIDINE 是一种从花椒根中分离出来的具有生物活性的植物苯并菲啶生物碱。它具有抗癌、神经保护、抗疟疾、抗 HIV、镇痛、抗炎和抗真菌活性。
T3819	Ursolic acid acetate 熊果酸乙酸酯,Acetylursolic acid,3-Acetylursolic Acid	AChE	Neuroscience
	Ursolic acid acetate (Acetylursolic acid) 分离于 Ficus microcarpa 的气根中，对 KB 细胞显示细胞毒性(IC50:8.4 μM)。
T0194	Chloroquine phosphate Chloroquine diphosphate,Aralen phosphate,磷酸氯喹,Chingamin phosphate	SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Chloroquine phosphate (Aralen phosphate) 是广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。它是autophagy 和toll-like receptors 抑制剂，有效抑制SARS-CoV-2(COVID-19) 感染 (EC50=1.13 μM)。
T21065	Artemisitene	Others	Others
	Artemisitene 是青蒿素的氧化形式，是一种抗疟药。青蒿素前体是青蒿素生物合成的重要基础物质，包括青蒿素 B、青蒿素、青蒿酸等。
TN1100	Nepodin	transporter; COX; AMPK; Parasite	Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling
	Nepodin 是从Rumex crispus 中分离的一种醌氧化还原酶抑制剂，具有抗糖尿病和抗疟疾的作用。。它通过激活 AMPK 刺激 GLUT4 向质膜的转运。
T2830	Betulinic acid 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid	Apoptosis; Mitophagy; NF-κB; HIV Protease; Topoisomerase; Endogenous Metabolite; Aminopeptidase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Betulinic acid (ALS-357) 是从白桦树皮中分离出来的一种五环三萜类天然产物，是真核细胞拓扑异构酶 I 的抑制剂，IC50值为 5 μM，具有抗逆转录病毒、抗疟疾、抗癌和抗炎特性。
TN1393	(-)-Anonaine 番荔枝碱	Apoptosis; Antioxidant; Parasite; Antifungal	Apoptosis; Microbiology/Virology; oxidation-reduction
	(-)-Anonaine 可从木兰科和安妮科的几个物种中提取出来，具有抗疟、抗菌、抗真菌、抗氧化、抗癌、抗抑郁和血管舒张的活性。(-)-Anonaine 通过 Bax 和 caspase 依赖性途径诱导人类宫颈癌（HeLa）细胞的凋亡，诱导 DNA 损伤并抑制人类肺癌 h1299细胞的生长和迁移。
TN4883	Quinine sulfate dihydrate 奎宁树	Others	Others
	Quinine sulfate dihydrate 在钾通道阻滞剂中起主要作用。它也被用作抗疟疾、抗胆碱能、抗高血压和降糖药。它抑制线粒体atp 调节的钾通道。它也被用来研究生物结晶血红素，血红素，在疟疾寄生虫的代谢和研究血红素(FP)复合物的毒性。
T3417	Amentoflavone Didemethyl-ginkgetin,穗花杉双黄酮,Amenthoflavone,3',8''-Biapigenin	Apoptosis; P450; Phospholipase; Reactive Oxygen Species; Opioid Receptor; COX; Antibacterial; RSV; Antifungal	Apoptosis; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	Amentoflavone (3',8''-Biapigenin) 是一种具有很多生物活性的双黄酮类天然产物，有抗炎、抗氧化和神经保护等作用。
TN2254	Taccalonolide A 根薯酮内酯A,根薯酮内酯 A	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Taccalonolide A 是从水田七根茎中分离得到的一种类固醇，具有细胞毒性和抗疟活性。它在体外对过表达 p 糖蛋白、多药耐药蛋白 7 细胞系有抑制作用，抑制 SK-OV-3 细胞生长的 IC50值为 622 nM。它是微管稳定剂，能引起 G2-M 期滞留、Bcl-2 磷酸化，并引发细胞凋亡。
TN4276	Isocudraniaxanthone B	Sodium Channel; Antifection	Membrane transporter/Ion channel; Microbiology/Virology
	Isocudraniaxanthone B may have antimalarial activity.
TN5937	Walsuronoid B
	Walsuronoid B shows weak antimalarial activity.
TN4314	Isonardoperoxide	Antifection	Microbiology/Virology
	Isonardoperoxide shows strong antimalarial activity against Plasmodium falciparum malaria (6.0 × 10-7 M).
TN3452	Arteannuin M	TNF; Antifection	Apoptosis; Microbiology/Virology
	Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
TN4229	Humulene epoxide II	Antifection	Microbiology/Virology
	Humulene epoxide II has antimalarial activity.
TN3583	Canophyllal	Antifection	Microbiology/Virology
	Canophyllal shows antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs.
T12517	Polyketomycin	Others	Others
	Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes, has antibacterial, anticancer, antimalarial activities.
TN4535	Methyl 6-acetoxyangolensate	Antifection	Microbiology/Virology
	Methyl-6-acetoxy angolensate may have antimalarial activity.
T11534	Haemanthamine	Others	Others
	Haemanthamine is an alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. It inhibits protein biosynthesis during the elongation stage of translation. It has antimalarial, pro-apoptotic, antiviral, antioxidant, and anticonvulsa
TN4275	Isocudraniaxanthone A	Antifection	Microbiology/Virology
	Isocudraniaxanthone A may have antimalarial activity.
TN3453	Arteannuin N	TNF; Antifection	Apoptosis; Microbiology/Virology
	Arteannuin has antimalarial activity. It can degrade the level of TNF-α in rats with ostarthritis,and effectively inhibit the inflammation.
TN4666	Norcaesalpinin E	Antifection	Microbiology/Virology
	Norcaesalpinin E shows antimalarial activity against the malaria parasite Plasmodium falciparum FCR-3/A2 clone in vitro, with an IC50 value of 0.090 microM.
TN3427	Aphadilactone B	Antifection	Microbiology/Virology
	Aphadilactone B shows significant antimalarial activity with the IC50 value of 1350 ± 150 nM.
T79997	(±)-Emodin bianthrone	Parasite	Microbiology/Virology
	(±)-Emodin bianthrone (compound 10) 是具抗疟、抗结核及抗真菌作用的天然化合物。
TN4733	Pancixanthone A 胡桐，海棠木	Antifection	Microbiology/Virology
	Pancixanthone A may have antimalarial activity, it also shows a significant antileishmanial activity against the promastigote forms of Leishmania mexicana and L. infantum and against the amastigote forms of L. infantum.
TN1349	9-Hydroxycalabaxanthone	Antifection	Microbiology/Virology
	9-Hydroxycalabaxanthone exhibits cytotoxicity against the HT-29 cell line with ED50 values of 9.1 microM. The combination of 9-hydroxycalabaxanthone with α±-mangostin shows the synergistic antimalarial interaction in both clones.
T40643	Prodigiosin hydrochloride 盐酸灵菌红素,Prodigiosine hydrochloride
	Prodigiosin hydrochloride, a red pigment, is a bioactive secondary metabolite produced by bacteria. It exhibits potent proapoptotic activity and functions as an inhibitor of the Wnt/β-catenin pathway. Additionally, this compound possesses antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive, and anticancer properties.
TN2738	2,6-Dimethoxy-1-acetonylquinol	Antifection	Microbiology/Virology
	2,6-Dimethoxy-1-acetonylquinol shows varying degrees of in vitro antimalarial activity against Plasmodium falciparum. It is devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line.
TN3799	Dehydrocrebanine	Antifection	Microbiology/Virology
	Dehydrocrebanine has strong activity against promyelocytic leukemia cells (HL-60) with an IC50 of 2.14 ug/mL. It also shows potent antimalarial activity with an IC50 value of 70 ng/ml.
TN2567	10-Hydroxycanthin-6-one	Antifection	Microbiology/Virology
	10-Hydroxycanthin-6-one has potential to be an antimicrobial agent. 10-Hydroxycanthin-6-one has in vitro antimalarial activity; it also has cytotoxic activity, it could be a plant anticancer agent.
TN3422	Anisofolin A	Antifection	Microbiology/Virology
	Anisofolin A has promising antimalarial activity (IC50 4.39 ± 0.25 uM). It has promising antimycobacterium activity [IC50 4.50 ± 0.75 uM (3.31 ug/mL)] against M. tuberculosis H37Ra and at 100 ug/mL, shows 55.6 % inhibition of M. bovis.
TN3428	Aphadilactone C	Others	Others
	Aphadilactone C shows significant antimalarial activity with the IC50 value of 170 ± 10 nM. It shows potent and selective inhibition against the diacylglycerol O-acyltransferase-1 (DGAT-1) enzyme (IC50 = 0.46 ± 0.09 uM, selectivity index > 217).
TN4776	Physalin D	TNF; Antifection	Apoptosis; Microbiology/Virology
	Physalin D shows antimalarial activity; it also exhibits a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 microg/mL. Physalin D displays considerable cytotoxicity against several cancer cell lines. It
T75663	7-Methoxy-β-carboline-1-propionic acid
	7-Methoxy-β-carboline-1-propionic acid (compound 46) 是一种从东革阿里根中提取的化合物，具有细胞毒性和抗疟疾功能。
T64246	Cinchonine monohydrochloride hydrate
	Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate 是一种天然的、有效的抗疟剂，也是一种人血小板聚集的抑制剂。Cinchonine monohydrochloride hydrate 能够激活内质网应激，诱导的人肝癌细胞凋亡，并可抑制脂肪的生成。
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天然产物

Tuberostemonine

Cat.No: T6S0084

Synonym: 对叶百部碱,Tuberstemonine

Target: Parasite

Cat.No: T10835

Synonym: Desethylhydroxychloroquine

Target: Parasite, Antifection

Oxysanguinarine

Cat.No: TN2027

Synonym: 8-Oxosanguinarine,氧化血根碱,Hydroxysanguinarine

Target: Parasite

Cat.No: TN1019

Synonym: β-Mangostin,beta-倒捻子素

Target: Apoptosis, Antibacterial, Parasite

Cat.No: TN1012

Target: IL Receptor, Anti-infection, Parasite

Febrifugine dihydrochloride

Cat.No: TN1012L

Synonym: ISF-2123,Propyldazine hydrochloride,Atensil,(+)-Febrifugine dihydrochloride,常山乙素二盐酸盐,Pildralazine dihydrochloride

Target: Parasite

Cat.No: T3324

Synonym: Galanthidine,Narcissine,石蒜碱,Amarylline,Belamarine,Licorine,番石榴碱

Target: Apoptosis, Virus Protease, Antibacterial, AChR, Fatty Acid Synthase

α-Dihydroartemisinin

Cat.No: T7059

Synonym: α-Artenimol,α-Dihydroqinghaosu

Target: Parasite

Cat.No: TN1145

Target: Parasite

Cat.No: T3S1447

Target: SARS-CoV, Ferroptosis

Cat.No: T1323

Synonym: SM224,蒿甲醚,Dihydroartemisinin methyl ether,Dihydroqinghaosu methyl ether,CGP 56696

Target: Antibiotic, Parasite

Cat.No: T25114

Synonym: NSC-406266,NSC 406266,NSC406266

Target: Parasite

Cat.No: T3327

Synonym: SM-227,β-Arteether,Beta-Arteether,蒿乙醚,Arteether,(+)-Arteether

Target: CXCR, CCR, Parasite

Quinine dihydrochloride

Cat.No: T4333

Synonym: 盐酸奎宁,Quinine bimuriate

Target: Others

Cat.No: T7938

Synonym: 奎尼丁,奎宁树

Target: Parasite

Cat.No: T8859

Target: Others

Ursolic acid acetate

Cat.No: T3819

Synonym: 熊果酸乙酸酯,Acetylursolic acid,3-Acetylursolic Acid

Target: AChE

Chloroquine phosphate

Cat.No: T0194

Synonym: Chloroquine diphosphate,Aralen phosphate,磷酸氯喹,Chingamin phosphate

Target: SARS-CoV, TLR, HIV Protease, Antibiotic, Parasite, Autophagy

Cat.No: T21065

Target: Others

Cat.No: TN1100

Target: transporter, COX, AMPK, Parasite

Cat.No: T2830

Synonym: 白桦脂酸,桦木酸,ALS-357,Lupatic acid,Betulic acid

Target: Apoptosis, Mitophagy, NF-κB, HIV Protease, Topoisomerase, Endogenous Metabolite, Aminopeptidase, Autophagy

Cat.No: TN1393

Synonym: 番荔枝碱

Target: Apoptosis, Antioxidant, Parasite, Antifungal

Quinine sulfate dihydrate

Cat.No: TN4883

Synonym: 奎宁树

Target: Others

Cat.No: T3417

Synonym: Didemethyl-ginkgetin,穗花杉双黄酮,Amenthoflavone,3',8''-Biapigenin

Target: Apoptosis, P450, Phospholipase, Reactive Oxygen Species, Opioid Receptor, COX, Antibacterial, RSV, Antifungal

Taccalonolide A

Cat.No: TN2254

Synonym: 根薯酮内酯A,根薯酮内酯 A

Target: Apoptosis, Microtubule Associated

Isocudraniaxanthone B

Cat.No: TN4276

Target: Sodium Channel, Antifection

Cat.No: TN5937

Isonardoperoxide

Cat.No: TN4314

Target: Antifection

Cat.No: TN3452

Target: TNF, Antifection

Humulene epoxide II

Cat.No: TN4229

Target: Antifection

Cat.No: TN3583

Target: Antifection

Cat.No: T12517

Target: Others

Methyl 6-acetoxyangolensate

Cat.No: TN4535

Target: Antifection

Cat.No: T11534

Target: Others

Isocudraniaxanthone A

Cat.No: TN4275

Target: Antifection

Cat.No: TN3453

Target: TNF, Antifection

Norcaesalpinin E

Cat.No: TN4666

Target: Antifection

Aphadilactone B

Cat.No: TN3427

Target: Antifection

(±)-Emodin bianthrone

Cat.No: T79997

Target: Parasite

Pancixanthone A

Cat.No: TN4733

Synonym: 胡桐，海棠木

Target: Antifection

9-Hydroxycalabaxanthone

Cat.No: TN1349

Target: Antifection

Prodigiosin hydrochloride

Cat.No: T40643

Synonym: 盐酸灵菌红素,Prodigiosine hydrochloride

2,6-Dimethoxy-1-acetonylquinol

Cat.No: TN2738

Target: Antifection

Dehydrocrebanine

Cat.No: TN3799

Target: Antifection

10-Hydroxycanthin-6-one

Cat.No: TN2567

Target: Antifection

Cat.No: TN3422

Target: Antifection

Aphadilactone C

Cat.No: TN3428

Target: Others

Cat.No: TN4776

Target: TNF, Antifection

7-Methoxy-β-carboline-1-propionic acid

Cat.No: T75663

Cinchonine monohydrochloride hydrate

Cat.No: T64246

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