Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) 是一种具有口服活性的组胺 N-甲基转移酶抑制剂,也是一种Nurr1激动剂,可特异性结合Nurr1的配体结合域,EC50约为20 μM。它是 4-氨基喹啉衍生物,具有抗疟和抗炎特性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 236 | 现货 | ||
100 mg | ¥ 413 | 现货 | ||
200 mg | ¥ 588 | 现货 | ||
500 mg | ¥ 980 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 163 | 现货 |
产品描述 | Amodiaquine dihydrochloride dihydrate (Amodiaquine hydrochloride) is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties. |
靶点活性 | Histamine N-methyl transferase:18.6 nM(Ki) |
体内活性 | 在体内给予小剂量的 Amodiaquine dihydrochloride dihydrate 对狗的胃液分泌具有显著增效作用,能显著增强组胺的效应[3]。Amodiaquine dihydrochloride dihydrate 能够预防由P. acnes诱导和LPS加剧的严重肝损伤,且治疗可增强这类小鼠肝脏内组胺水平的升高而不伴随远端甲基组胺的增高[1]。 |
激酶实验 | Whole-cell competitive binding assays: Whole-cell competitive binding assays are performed in LNCaP/AR(codon-switch) (LNCaP/AR(cs)) (harbors a mixture of exogenous wild-type AR and endogenous mutant AR (T877A)) and cells propagated in Iscove's or RPMI media supplemented with 10% fetal bovine serum, or during the assay with 10% charcoal-stripped, dextran-treated fetal bovine serum (CSS). Cells are pre-incubated with 18F-FDHT, increasing concentrations (1pM to 1 μM) of cold Bicalutamide are added, and the assay is performed to measure specific uptake of 18F-FDHT (4). IC50 values are determined using a one site binding model with least squares curve fitting and R2 > 0.99. |
别名 | Amodiaquine hydrochloride, 阿莫地喹盐酸盐, Amodiaquin dihydrochloride dihydrate |
分子量 | 464.82 |
分子式 | C20H28Cl3N3O3 |
CAS No. | 6398-98-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 85 mg/mL (182.9 mM)
H2O: 27 mg/mL (58.1 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 2.1514 mL | 10.7569 mL | 21.5137 mL | 53.7843 mL |
5 mM | 0.4303 mL | 2.1514 mL | 4.3027 mL | 10.7569 mL | |
10 mM | 0.2151 mL | 1.0757 mL | 2.1514 mL | 5.3784 mL | |
20 mM | 0.1076 mL | 0.5378 mL | 1.0757 mL | 2.6892 mL | |
50 mM | 0.043 mL | 0.2151 mL | 0.4303 mL | 1.0757 mL | |
DMSO | 100 mM | 0.0215 mL | 0.1076 mL | 0.2151 mL | 0.5378 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Amodiaquine dihydrochloride dihydrate 6398-98-7 Chromatin/Epigenetic GPCR/G Protein Immunology/Inflammation Microbiology/Virology Neuroscience Histone Methyltransferase Parasite Histamine Receptor antimalarial anti-inflammatory CXCL2 CCL2 N-methyltransferase neuroprotective Amodiaquine hydrochloride Amodiaquin dihydrochloride Dihydrate Inhibitor Amodiaquine Amodiaquine Hydrochloride Amodiaquine dihydrochloride Dihydrate IL-1β 阿莫地喹盐酸盐 Nurr1 Amodiaquin dihydrochloride dihydrate inhibit Amodiaquin inhibitor