43
19
2
45
Cat. No. | Product Name | ||
---|---|---|---|
L4700 | 免疫/炎症分子化合物库 | 4720 compounds | |
4720 种具有抗炎症活性的化合物的特有集合,可用于高通量筛选和高内涵筛选; | |||
L9810 | 抗纤维化化合物库 | 1155 compounds | |
1155 种潜在的抗纤维化分子,是研究纤维化的有效工具,可以用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T77494 |
TNF-α-IN-9
|
TNF | Apoptosis |
TNF-α-IN-9 是一种 NDM-1 inhibitor-3类似物,是一种 TNF-α 抑制剂。TNF-α-IN-9 显示低抑制活性。 | |||
T19584L |
TNF-α (31-45), human acetate
TNF-α (31-45), human acetate(144796-71-4 free base) |
Others | Others |
TNF-α (31-45), human acetate(144796-71-4 free base) 是一种肿瘤坏死因子-α 的肽。 | |||
T4637 |
R-7050
TNF-α Antagonist III |
TNF | Apoptosis |
R-7050 (TNF-α Antagonist III) 是一种肿瘤坏死因子受体拮抗剂,对 TNFα具有更高选择性。 | |||
T36097 | TNF-α-IN-2 | ||
TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in the TNFα trimer upon binding, resulting in disrupted signaling when the trimer interacts with TNFR1. TNF-α-IN-2 holds promise as a valuable tool for investigating the pathogenesis of rheumatoid arthritis[1]. | |||
TP1537 |
TNF-α (10-36), human
|
||
TNF-α (10-36), human is a potent pro-inflammatory cytokine involved in the acute phase stress response. | |||
T36127 |
TNF-α Antagonist
|
||
TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destr... | |||
T13175 |
TNF-α-IN-1
|
TNF | Apoptosis |
TNF-α-IN-1是 TNF-α 抑制剂。 | |||
T40321 | TNF-α-IN-6 | ||
TNF-α-IN-6 is an orally efficacious allosteric inhibitor of TNFα ( K D = 6.8 nM). | |||
TP1626 |
TNF-α (46-65), human
|
||
Human TNF alpha (46-65) peptide. | |||
T19584 |
TNF-α (31-45), human
|
Others | Others |
TNF-α (31-45), human is a peptide of tumor necrosis factor-α. | |||
TP1479 |
TNF-α (10-36), human (TFA) (144796-70-3 free base)
TNF-α (10-36), human (TFA) |
||
TNF-α (10-36), human (TFA) is a peptide of human TNF-α. | |||
T4403 |
AX-024 hydrochloride
AX-024 HCl |
IL Receptor; TNF; COX; IFNAR; Interleukin | Apoptosis; Immunology/Inflammation; Neuroscience |
AX-024 hydrochloride (AX-024 HCl) 是一种细胞因子释放抑制剂,可强烈抑制 IL-6、TNFα、IFN-γ、IL-10 和 IL-17A 的产生。它是口服可利用的 TCR-Nck 相互作用抑制剂,可选择性地抑制 TCR 触发的 T 细胞活化。它通过靶向 SH3结构域调节细胞信号传导,具有低毒、高效和高选择性的特点。 | |||
TP1669 |
TNF-α (46-65), human TFA (144796-72-5 free base)
TNF-α (46-65), human TFA |
||
TNF-α (46-65), human (TFA) is a peptide of human TNF-α. | |||
TP1636 |
TNF-α (31-45), human TFA (144796-71-4 free base)
TNF-α (31-45), human TFA |
||
TNF-α (31-45), human (TFA) is a peptide of tumor necrosis factor-α. | |||
T78272 |
Anti-Mouse TNF alpha Antibody (TN3-19.12)
|
||
Anti-Mouse TNF alpha Antibody为Rat宿主源的IgG类针对小鼠TNF alpha的抗体抑制剂。 | |||
T78434 |
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA
|
||
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA 为基于荧光共振能量转移的多肽底物,通过裂解引起的荧光强度变化来确定其活性。 | |||
T81838 |
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human)
|
||
Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) 为一种基于FRET (荧光共振能量转移) 原理的多肽底物,通过其裂解引起的荧光强度变化来评估其活性。 | |||
T9901 |
Adalimumab
|
TNF | Apoptosis |
Adalimumab 是人源的单克隆 IgG1 抗体,靶向肿瘤坏死因子α。 | |||
TP1615L |
IKKγ NBD Inhibitory Peptide acetate
IKKγ NBD Inhibitory Peptide acetate(372146-18-4 free base) |
NF-κB | NF-κB |
IKKγ NBD Inhibitory Peptide acetate 是一种 NEMO 结合结构域肽(NBD 肽)乙酸盐,对应于 NEMO 氨基末端 α-螺旋区域。它显示可阻断 TNF-α 诱导的 NF-kB 活化。 | |||
T4412 |
Roquinimex
Linomide,罗喹美克,LS2616,FCF89,ABR212616 |
TNF | Apoptosis |
Roquinimex (FCF89) 是一种喹啉衍生物免疫刺激剂,可增加 NK 细胞活性和巨噬细胞的细胞毒性,抑制血管生成并减少 TNF α 的分泌。 | |||
T10865 |
Cot inhibitor-1
|
TNF; MAPK | Apoptosis; MAPK |
Cot inhibitor-1 是一种选择性的 Cot 蛋白激酶(也被称为 Tpl2或 MAP3K8)抑制剂(IC50 为 28 nM)。Cot inhibitor-1 抑制人全血中 TNF-alpha 的产生,其 IC50 为 5.7 nM。Cot 参与多种细胞信号通路,特别是与炎症和免疫反应有关的信号通路。Cot inhibitor-1抑制 Cot 活性,可能对类风湿关节炎、炎症性肠病和某些类型的癌症具有潜在的治疗效果。 | |||
T24816 |
SP-100030
SP100030,SP 100030 |
NF-κB | NF-κB |
SP-100030 是一种有效的 NF-κB 和激活蛋白-1 (AP-1) 双抑制剂 (IC50 分别为 50 和 50 nM)。SP-10003 抑制 Jurkat 和其他T 细胞系产生的 IL-2、IL-8 和 TNF-α 的产生。SP-100030 降低小鼠胶原性关节炎 (CIA)。 | |||
T7091 |
N-Formyl-Met-Leu-Phe
fMLP,N-Formyl-MLF |
TNF | Apoptosis |
N-Formyl-Met-Leu-Phe (N-Formyl-MLF) 是一种趋化肽和N-甲酰基肽受体的特异性配体,可抑制TNF-alpha 的分泌。 | |||
T1562 |
Rebamipide
Proamipide,OPC12759,瑞巴派特 |
Free radical scavengers; COX; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience; oxidation-reduction |
Rebamipide (OPC12759) 是一种粘膜保护剂,可诱导COX-2表达,增加PGE2水平,并以 COX-2 依赖性方式增强胃粘膜防御。 | |||
T26624 |
AN0128
AN 0128,CRM-0005,CRM0005,ONT0001,AN-0128,ONT-0001 |
||
AN 0128 is a tumour necrosis factor alpha (TNF-α) inhibitor. | |||
T77064 | Licaminlimab | ||
Licaminlimab (OCS-02) 是一种单链抗TNF alpha 抗体片段。TNF alpha 是巨噬细胞和单核细胞在炎症过程中产生的炎症细胞因子。 | |||
T27142 |
Delmitide
Rationally Designed Peptide-58,RDP-1258,RDP5,Allotrap-1258,RDP1258,RDP-5 |
||
Delmitide, a TNF-alpha production inhibitor, is used potentially for the treatment of Crohn's disease and ulcerative colitis. | |||
T69594 |
IM-491
|
||
IM-491 is a TNF-alpha converting enzyme inhibitor. | |||
T76026 |
TNF-α (31-45), human TFA
|
||
TNF-α (31-45), human TFA 是人肿瘤坏死因子-α 的多肽片段。TNF α 是一种炎性细胞因子,可诱导坏死或凋亡。 | |||
T71022 |
GI-129471
|
||
GI-129471 is a metalloproteinase inhibitor, specifically blocking TNF-alpha secretion both in vitro and in vivo. | |||
T69716 |
Solimastat
|
||
Solimastat is a novel oral, broad-spectrum matrix metalloproteinase inhibitor (MMPI), being >10-fold more active than marimastat in inhibiting the processing of cell-bound TNF-alpha. | |||
T27507 |
GW-3333
GW 3333,GW3333 |
||
GW-3333 is an matrix metalloproteinase inhibitor. It is also a tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) inhibitor. The efficacy of GW3333 suggests that dual inhibitors of matrix metalloproteinases and TACE may prove therapeutic as antiar | |||
T64264 | ISIS 104838 | ||
ISIS 104838 是一种反义寡核苷酸药物,能够抑制肿瘤坏死因子 (TNF-alpha) 的产生,造成类风湿关节炎关节疼痛和肿胀。 | |||
T69205 |
GGTI-2166
|
||
GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells. | |||
T81606 |
Onercept
|
||
Onercept为重组可溶性人类肿瘤坏死因子-α p55受体,用于Crohn's disease研究。 | |||
TP1615 |
IKKγ NBD Inhibitory Peptide
|
||
A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO with the IKK complex is vital for t | |||
T70280 |
KB-R7785
|
||
KB-R7785 is a novel ADAM12 and MMP inhibitor, ameliorating cardiac function in a transverse aortic constriction (TAC) model by inhibiting the proteolytic activation of HB-EGF signaling, exerting its antidiabetic effect by ameliorating insulin sensitivity through the inhibition of TNF-alpha production. | |||
T69223 | CC-1088 | ||
CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). SelCIDs inhibit phosphodiesterase-4 (PDE 4), an enzyme involved in tumor necrosis factor alpha (TNF alpha) production. CC-1088 inhibits production of the cytokines vascular endothelial growth factor (VEGF) (a pro-angiogenic factor) and interleukin-6 (IL-6). | |||
T78548 |
3-Hydroxyxanthone
3-Hydroxy-xanthen-9-one |
Integrin | Cytoskeletal Signaling |
3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one) 是一种具有抗炎活性的氧杂蒽酮化合物。它能抑制人脐静脉内皮细胞(HUVEC)中NADPH催化的脂质过氧化,并且阻止TNF-α所诱导的ICAM-1表达。 | |||
T76963 | Certolizumab pegol | ||
Certolizumab pegol (Certolizumab) 是经过重组和聚乙二醇化处理的人源化单克隆抗体抗原结合片段,它选择性地靶向并中和肿瘤坏死因子-α (TNF-α)。适用于类风湿关节炎和克罗恩病的研究领域。 | |||
T80973 |
TNF-α-IN-8
|
||
TNF-α-IN-8 (compound I-42) 作为一种TNF-α抑制剂,属于异吲哚-亚胺类化合物,适用于肿瘤、心脏病、骨质疏松、炎症、过敏及自身免疫性疾病的研究。作为点击化学试剂,其Azide基团能与含Alkyne的分子配对,通过铜催化的叠氮-炔环加成反应(CuAAc)产生反应,也可与含DBCO或BCN基团的分子进行菌株促进的炔-叠氮环加成反应(SPAAC)。 | |||
T72687 | Keap1-Nrf2-IN-11 | ||
Keap1-Nrf2-IN-11为Keap1-Nrf2抑制剂,KD2值达0.21 nM。该化合物可有效抑制ROS及NO的生成,并降低TNF-α的表达。通过促进Nrf2的核内转移,Keap1-Nrf2-IN-11对炎症具有调节作用,适用于抗炎研究。 | |||
T36618 |
Rupatadine
|
||
Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited histamine-induced guinea pig ileum contraction (pA2 = 9.29 +/- 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4). It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in hu... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5660 |
Menthone
|
IL Receptor; TNF; NF-κB; Parasite | Apoptosis; Immunology/Inflammation; Microbiology/Virology; NF-κB |
Menthone 是一种从植物和薄荷油中提取的单萜,是精油的主要挥发性成分,具有抗炎和抗氧化特性。 | |||
T3927 |
Phellopterin
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Phellopterin 是一种分离自P. trifoliata 中的天然产物。它能够调节 Akt 和 PKC 通路,抑制 TNF-alpha 诱导的 VCAM-1 表达,进而减少单核细胞与内皮细胞的粘附。 | |||
T3805 |
Prim-O-glucosylcimifugin
升麻苷,Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside |
TNF; COX; JAK; NO Synthase | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells |
Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) 具有强效的抗炎作用。通过调节 JAK2/STAT3 信号传导可抑制iNOS 和COX-2表达。 | |||
T4S0795 |
Berberrubine chloride
9-Berberoline Chloride,Beroline,Beroline Chloride,小檗红碱,Berberrubine,9-Berberoline |
IL Receptor | Immunology/Inflammation |
Berberrubine chloride (9-Berberoline Chloride) 是一种黄连素的有效代谢物,能够改善动物模型中溃疡性结肠炎的症状。 | |||
T6S1256 |
Ruscogenin
|
NOS; NF-κB; NOD-like Receptor (NLR) | Immunology/Inflammation; NF-κB |
Ruscogenin 是一种重要甾体皂苷元,提取自麦冬。它能够抑制 TXNIP/NLRP3炎症体激活和 MAPK 途径,改善脑缺血诱导的血脑屏障功能障碍,具有显著抗血栓、抗炎作用。 | |||
T2823 |
Crocin
西红花苷,藏红花,Gardenia Yellow,Alpha-Crocin,藏红花素 |
Others | Others |
Crocin (Gardenia Yellow) 是从Crocus sativus 柱头中分离出的主要成分,是一种营养保健品,具有抗炎,抗癌,抗抑郁和抗惊厥等强大的药理作用。 | |||
T4S1615 |
Sanggenon C
桑根酮C,桑根酮 C,Sanggenone C |
NF-κB | NF-κB |
Sanggenon C (Sanggenone C) 是一种从桑属的根皮中分离得到的黄烷酮 Diels-Alder 加合物化合物。它可抑制NF-κB 活性,抑制 RAW264.7 细胞中诱导型一氧化氮合酶的表达,以及肿瘤坏死因子-α 刺激的细胞粘附和血管细胞粘附分子-1 的表达。 它具有抗氧化和抗炎作用,也有抑制胰脂肪酶作用。 | |||
T3893 |
Forsythoside B
连翘酯苷 B,连翘脂苷B |
TNF; NF-κB | Apoptosis; NF-κB |
Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha,IL-6,IκB, 调节 NF-κB。它抑制炎症反应,具有抗氧化和神经保护作用。 | |||
TMA0627 | Taxiresinol | TNF | Apoptosis |
Taxiresinol shows anticancer, antinociceptive, and antiallergic activities, it shows inhibitory activity on induced histamine release from the human basophilic cell line, KU812. Taxiresinol can protect the hepatocytes from apoptosis via an inhibition of TNF- alpha production by activated macrophages and a direct inhibition of apoptosis induced by TNF- alpha in D-GalN/LPS-treated mice. | |||
TMA2576 |
Episappanol
|
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α). | |||
TN4243 | Hyuganin D | TNF | Apoptosis |
Hyuganin D can inhibit LPS-induced NO and/or TNF-alpha production in mouse peritoneal macrophages. | |||
TN4334 | Isotaxiresinol | TNF | Apoptosis |
Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. Isotaxiresinol ma | |||
TN1458 |
Buddlejasaponin IV
|
PARP; Akt; Chk | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-kappaB activation. | |||
TN5351 |
Cycloshizukaol A
|
||
Cycloshizukaol A prevents monocyte adhesion to HUVEC through the inhibition of cell adhesion molecules expression stimulated by TNF-alpha, it inhibits PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity with MIC values of 0.9 microM. | |||
TN4303 |
Isokaempferide
|
ATPase; Potassium Channel; Calcium Channel; TNF; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism |
Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by reducing neutrophil degranulation, myeloperoxidase activity, mediators as well as TNF-alpha secretion. Isokaempferide is used as a bronchodilator, can induce relaxation of guinea-pig isolated trachea. | |||
TN4146 | Glutinol acetate | TNF | Apoptosis |
Glutinol acetate shows significant cytotoxic activity against four human cancer cell lines (HL-60, SK-OV-3, A549, and HT-29), with GI(50) in the range of 11.1-17.9microM; it also has anti-inflammatory effect, exhibits moderate inhibitory activity of TNF-alpha secretion in the lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cell line. | |||
TN5474 |
Bonducellin
|
||
Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bonducellin shows weak antimalarial ac | |||
TN2243 |
Sugiol
10-Deoxoxanthoperol |
IL Receptor; TNF; ROS | Apoptosis; Immunology/Inflammation |
Sugiol (10-Deoxoxanthoperol) 是一种枞烷二萜,可从台湾板栗树 (Calocedrus formosana) 的树皮中分离出来。Sugiol 具有抗炎活性,可有效减少脂多糖 (LPS) 刺激巨噬细胞后的活性氧 (ROS) 产生。 | |||
TN5011 |
Shizukaol B
|
ERK; IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; HIV Protease; DNA/RNA Synthesis; Prostaglandin Receptor; JNK | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome |
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimul |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00779 |
TNF alpha Protein, Rabbit, Recombinant
TNF-a,Tumor Necrosis Factor,TNF-α,TNF<... |
Rabbit | E. coli |
Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor type 2,p75R). TNFα is a pleiotropic cytokine that is capable to promote inflammation, to induce apoptotic cell death, and to inhibit tumorigenesis and viral replication. TNFα is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other ... | |||
TMPY-01294 |
TNF alpha Protein, Mouse, Recombinant
TNF-α,Tnfsf1a,TNF-alpha,... |
Mouse | E. coli |
TNF alpha Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.39 kDa and the accession number is P06804. | |||
TMPY-00936 |
TNF alpha Protein, Human, Recombinant
TNFA,TNFSF2,TNF-alpha, |
Human | E. coli |
TNF alpha Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375. | |||
TMPY-04146 |
TNF alpha Protein, Human, Recombinant (hFc)
DIF,TNFA,tumor necrosis factor,TNFSF2,... |
Human | HEK293 Cells |
TNF alpha Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.8 kDa and the accession number is P01375. | |||
TMPK-00583 |
TNF alpha Protein, Ferret, Recombinant (His)
TNF-α,DIF,TNFα,TNF-alpha... |
Ferret | E. coli |
TNF alpha Protein, Ferret, Recombinant (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 18.88 kDa and the accession number is A3FBF1. | |||
TMPY-05187 |
TNF alpha Protein, Mouse, Recombinant, Biotinylated
Tnfa,TNFSF2,肿瘤坏死因子,Tnfsf1a,TN... |
Mouse | E. coli |
TNF alpha Protein, Mouse, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P06804. | |||
TMPK-00119 |
TNF alpha Protein, Cynomolgus, Recombinant (His)
TNF α,TNFα,APC1 protein,TNF-a... |
Cynomolgus | HEK293 Cells |
TNF alpha Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 18.35 kDa and the accession number is P79337. | |||
TMPY-05237 |
TNF alpha Protein, Human, Recombinant, Biotinylated
TNFSF2,DIF,TNF-α,tumor necrosis factor,肿瘤坏... |
Human | E. coli |
TNF alpha Protein, Human, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P01375. | |||
TMPK-00120 |
TNF alpha Protein, Human, Recombinant (His & Avi)
TNFα,APC1 protein,肿瘤坏死因子,TNFSF2,TNF |
Human | HEK293 Cells |
TNF alpha Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375. | |||
TMPJ-00124 |
TNF alpha Protein, Human, Recombinant (aa 77-233, His)
TNF-a,TNF-α,Tumor Necrosis Factor,TNF<... |
Human | E. coli |
TNF alpha Protein, Human, Recombinant (aa 77-233, His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 16 KDa and the accession number is P01375. | |||
TMPK-00121 |
TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated
TNF,TNF-alpha,TNFATN... |
Human | HEK293 Cells |
TNF alpha Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 20.3 kDa and the accession number is P01375. | |||
TMPY-02153 |
TNF beta Protein, Human, Recombinant
LT,TNF β,TNFSF1,肿瘤坏死因子,TNFB,lymph... |
Human | E. coli |
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS... | |||
TMPJ-00125 |
TNF alpha Protein, Human, Recombinant (aa 57-233, His)
TNFA,TNF-α,Cachectin,肿瘤坏死因子,TNF-<... |
Human | E. coli |
TNF alpha Protein, Human, Recombinant (aa 57-233, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18 KDa and the accession number is P01375. | |||
TMPY-02202 |
TNF alpha Protein, Rat, Recombinant
tumor necrosis factor,肿瘤坏死因子,TNF-α |
Rat | E. coli |
TNF alpha Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P16599. | |||
TMPJ-00288 |
TNF RII Protein, Human, Recombinant (mFc)
Tumor necrosis factor receptor 2,TNFRSF1B,p75,T... |
Human | HEK293 Cells |
TNF RII Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60 KDa and the accession number is P20333. | |||
TMPJ-00287 |
TNF RII Protein, Human, Recombinant (hFc)
TNF-R2,Tumor necrosis factor receptor superfamily m... |
Human | HEK293 Cells |
TNF RII Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 60-90 KDa and the accession number is P20333. | |||
TMPH-03745 |
TNF-alpha Protein, Zebrafish, Recombinant (His)
|
Danio rerio (Zebrafish) | E. coli |
TNF-alpha Protein, Zebrafish, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.6 kDa and the accession number is Q08CQ3. | |||
TMPY-02069 |
TNF alpha Protein, Cynomolgus, Rhesus, Recombinant
肿瘤坏死因子,TNF-α,tumor necrosis factor |
Cynomolgus,Rhesus | E. coli |
TNF alpha Protein, Cynomolgus, Rhesus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is NP_001040614.1. | |||
TMPY-01594 |
TNF alpha Protein, Canine, Recombinant
肿瘤坏死因子,TNF-α,tumor necrosis factor |
Canine | E. coli |
TNF alpha Protein, Canine, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A9LMQ0. | |||
TMPY-02226 |
TNF alpha Protein, Ferret, Recombinant
tumor necrosis factor,肿瘤坏死因子,TNF-α |
Ferret | E. coli |
TNF alpha Protein, Ferret, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa and the accession number is A3FBF1. | |||
TMPJ-00546 |
EFNA1 Protein, Human, Recombinant (hFc)
TNFAIP4,LERK1,Tumor Necrosis Factor α-Induced Prote... |
Human | HEK293 Cells |
Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the... | |||
TMPY-05516 |
TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated
肿瘤坏死因子,tumor necrosis factor,TNF-α |
Cynomolgus | E. coli |
TNF alpha Protein, Cynomolgus, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is P79337. | |||
TMPY-06981 |
IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)
interleukin 1 α,IL1,白介素,IL-1F1,IL1-α,IL-1A,IL1F1,白细胞介素,IL-1 ... |
Human | E. coli |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage... | |||
TMPJ-01172 |
IL-17 Protein, Mouse, Recombinant (His)
CTLA8,IL-17,IL-17A,Interleukin-17A,CTLA-8,Cytotoxic T-Lympho... |
Mouse | HEK293 Cells |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumato... | |||
TMPK-01382 |
TNFR2/CD120b/TNFR1B Protein, Cynomolgus, Recombinant (His)
p75TNFR,p75TBPII,CD120b,TNF-R75,TNF |
Cynomolgus | HEK293 Cells |
Tumor Necrosis Factor Receptor II (TNF RII), also known as TNFRSF1B, p75/p80, and CD120b, is a type I transmembrane protein that belongs to the TNF receptor superfamily. It has a molecular weight of approximately 75 kDa.Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects o... | |||
TMPY-03416 |
TNFAIP8 Protein, Human, Recombinant (His)
GG2-1,tumor necrosis factor, alpha-induced protein ... |
Human | E. coli |
Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8) family is a newly identified protein with vital roles in maintaining immune homeostasis. Tumor necrosis factor-alpha-inducible protein 8 (TNFAIP8) is a TNF-alpha inducible anti-apoptotic protein with multiple roles in tumor growth and survival. by the creation of cellular autophagy events, TNFAIP8 promotes cell survival and drug resistance in prostate cancer cells. TNFAIP8 regulates Hippo pathway through interacting with LATS1 to prom... | |||
TMPJ-01107 |
PAP Protein, Human, Recombinant (His)
PAP1,PAP,PDGFA-Associated Protein 1,HASPP28,28 kDa Heat- and... |
Human | E. coli |
Human PAP, also known as 28 kDa heat- and acid-stable phosphoprotein, PDGF-associated protein, PDGFA-associated protein 1, PDAP1, HASPP28, is a protein which belongs to the PDAP1 family. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. PDGF-Associated Protein (PAP) is a phosphoprotein that may enhance PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB. PDAP1 expression is induced by TNF-alpha, and cells overexpressing PDAP1 sho... | |||
TMPK-00564 |
TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His)
TBP1,TNF-RI,TNFAR,p55,p60,p55-R,TNF |
Cynomolgus | HEK293 Cells |
Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate the cell death and inflammation associated with TNF-α, while sparing or potentiating the protective effects of TNFR2 signalling. | |||
TMPH-02195 |
TXNDC17 Protein, Human, Recombinant (GST)
|
Human | E. coli |
Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. | |||
TMPJ-00930 |
VCAM-1 Protein, Mouse, Recombinant (hFc)
Vascular cell adhesion protein 1,Vcam1 |
Mouse | HEK293 Cells |
Vascular cell adhesion molecule 1 (VCAM-1) is a cell surface protein belonging to the immunoglobulin superfamily, the protein is expressed by activated endothelial cells and certain leukocytes (such as macrophages). IL-1 beta, IL-4, TNF-alpha and IFN-gamma induced the expression of VCAM-1. The human and mouse VCAM-1 proteins share approximately 76% amino acid similarity. Mouse VCAM-1 is Important in cell-cell recognition. it appears to function in leukocyte-endothelial cell adhesion, and interac... | |||
TMPH-02650 |
FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. | |||
TMPY-02246 |
HB-EGF Protein, Human, Recombinant
DTSF,DTR,HEGFL,heparin-binding EGF-like growth factor,DTS |
Human | Baculovirus Insect Cells |
Heparin-binding EGF-like growth factor (HBEGF), a member of the EGF family of growth factors, exerts its biological activity through activation of the EGFR and other ErbB receptors. Soluble mature HBEGF is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen and chemotactic factor for fibroblasts, smooth muscle cells but not endothelial cells. HBEGF activates two EGF receptor subtypes, HER1 and HER4, and binds to cell surface HSPG. The transmembrane form of... | |||
TMPJ-00109 |
LMIR2 Protein, Human, Recombinant (hFc)
IgSF16,Immunoglobulin Superfamily Member 16,CD300C,CLM-6,CMR... |
Human | HEK293 Cells |
CD300C is a single-pass type I membrane protein which belongs to the immunoregulatory signaling (IRS) family. CD300C contains one Ig-like V-type domain and is present on the surface of natural killer cells, granulocytes, most myeloid cells, dendritic cells, and a subpopulation of T and B lymphocytes. The CD300C (CMRF-35A) and CD300A (CMRF-35H) molecules are homologous leukocyte surface proteins. CD300a and CD300C play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion... | |||
TMPH-01560 |
IL-26 Protein, Human, Recombinant (His & Trx)
|
Human | E. coli |
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-T... | |||
TMPH-01559 |
IL-26 Protein, Human, Recombinant (His)
|
Human | P. pastoris (Yeast) |
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecula... | |||
TMPH-02287 |
ZRANB1 Protein, Human, Recombinant (His & Myc)
|
Human | E. coli |
Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling. ZRANB1 Prot... | |||
TMPH-02876 |
RIPK1 Protein, Mouse, Recombinant (His)
|
Mouse | E. coli |
Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, i... | |||
TMPY-00248 |
Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His)
Lymphotoxin β,lymphotoxin β (TNF superfamily, membe... |
Cynomolgus | Baculovirus Insect Cells |
LTB (Lymphotoxin Beta) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. Heat-labile enterotoxin B subunit (LTB) of enterotoxigenic Escherichia coli (ETEC) is both a strong mucosal adjuvant and immunogen. It is a subunit vaccine candidate to be used against ETEC-induced diarrhea. It has already been expressed in seve... | |||
TMPY-04412 |
Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST)
mitogen-activated protein kinase kinase kinase kinase 2,GCK,... |
Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein, and MAP4K2, is cytoplasm and peripheral membrane protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. MAP4K2 contains one CNH domain and one protein kinase domain. Although this kinase is found in many tissues, its express... | |||
TMPK-01103 |
LILRA3/CD85e Protein, Human, Recombinant (His & Avi)
HM43,LIR-4HM43e3,HM31,ILT-6,LIR4,CD85e,LILRA3,ILT6 |
Human | HEK293 Cells |
Human LILRA3, also known as Leukocyte Ig-like receptor 4 (LIR-4), CD85 antigen-like family member E, Immunogobulin-like transcript 6 (ILT-6) and monocyte inhibitory receptor HM43/HM31, is a 70 kD Ig superfamily member that belongs to the leukocyte receptor complex/cluster. Mature LILRA3 is 416 amino acids (aa) in length and contains four C2-type Ig-like domains. Unlike other LILR family members, LILRA3 is actively secreted.LILRA3 acts as soluble receptor for class I MHC antigens. LILRA3 binds b... | |||
TMPJ-01444 |
IL-17A Protein, Cynomolgus, Recombinant (His)
CTLA-8,CTLA8,IL17A,IL-17,IL-17A,Cytotoxic T-Lymphocyte-Assoc... |
Cynomolgus | HEK293 Cells |
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synt... | |||
TMPJ-01187 |
Siglec-E Protein, Mouse, Recombinant (hFc)
SiglecE,Siglec-E |
Mouse | HEK293 Cells |
Siglecs are sialic acid specific I‑type lectins that are characterized by an extracellular domain (ECD) with an N‑terminal Ig‑like V‑set domain followed by varying numbers of Ig‑like C2‑set domains. Mouse Siglec‑E, also known as Myeloid Inhibitory Siglec (MIS), is an 80 ‑ 85 kDa member of the CD33‑related subfamily of Siglecs. Rodent and primate Siglec gene families have significantly diverged, and Siglec‑9 is the most likely human ortholog of mouse Siglec‑E. Siglec‑E is expressed as a heavily N... | |||
TMPY-01033 |
IL-32 Protein, Human, Recombinant (isoform alpha, His)
IL-32δ,IL-32beta,IL32,TAIFc,IL-32γ,白介素,IL-32 Protein(isoform... |
Human | HEK293 Cells |
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,... | |||
TMPY-03308 |
ADAM17 Protein, Rat, Recombinant (His)
ADAM metallopeptidase domain 17 |
Rat | HEK293 Cells |
ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. The expression of ADAM17 may be inhibited by ethanol. It is involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. ADAM1... | |||
TMPH-02878 |
PTPRS Protein, Mouse, Recombinant (His & Myc)
|
Mouse | E. coli |
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteo... |