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109

抑制剂 & 化合物

34

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Cat. No.	Product Name	Target	Signaling Pathways
T13175	TNF-α-IN-1	TNF	Apoptosis
	TNF-α-IN-1是 TNF-α 抑制剂。
T4328	OSS_128167 SIRT6-IN-1	HBV; Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology
	OSS_128167 (SIRT6-IN-1) 是一种选择性沉默调节蛋白 6 (SIRT6) 抑制剂，对 SIRT6，SIRT1 和 SIRT2 的 IC50分别为 89 μM，1578 μM 和 751 μM。它具有抗 HBV、抗癌、抗炎和抗病毒活性，可抑制 HBV 的转录和复制。
T22698	TLR3-IN-1 CU CPT 4a	TLR	Immunology/Inflammation
	TLR3-IN-1 (CU CPT 4a) 是一种选择性的TLR3信号抑制剂，在 RAW 264.7 细胞中 IC50 为 3.44 μM。它可以抑制 TLR3/dsRNA 复合物介导的下游信号通路，并抑制全细胞中 TNF-α 和 IL-1β 的产生。
T77494	TNF-α-IN-9	TNF	Apoptosis
	TNF-α-IN-9 是一种 NDM-1 inhibitor-3类似物，是一种 TNF-α 抑制剂。TNF-α-IN-9 显示低抑制活性。
T60054	EJMC-1 N-(3-chloro-4-hydroxyphenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide	TNF	Apoptosis
	EJMC-1 是一种 TNF-α 抑制剂，IC50 值为 42 μM，可用于自身炎症性疾病的研究。
T10865L	Cot inhibitor-1 hydrochloride Cot inhibitor-1 hydrochloride(915365-57-0 Free base)	TNF; MAPK	Apoptosis; MAPK
	Cot inhibitor-1 hydrochloride 是肿瘤进展位点 2 激酶 (IC50 = 28 nM) 的抑制剂，可抑制人全血中 TNF-α 的产生 (IC50 = 5.7 nM)。
T9645	CU-115 N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide	TLR	Immunology/Inflammation
	CU-115 是一种有效的，选择性的 TLR8 拮抗剂。CU-115对 TLR8 和 TLR7的 IC50分别为1.04 µM 和=>50 µM。THP-1 细胞中，CU-115 减少了 R-848 激活的 TNF-α 和 IL-1β 的产生。
T2367	SKF-86002 SKF86002	p38 MAPK; TNF	Apoptosis; MAPK
	SKF-86002 是一种可口服的 p38 MAPK 抑制剂，具有抗炎和抗关节炎活性，可用于缓解疼痛的研究。它能抑制脂氧合酶和环氧合酶介导的花生四烯酸代谢，还抑制脂多糖 (LPS) 刺激人单核细胞产生 IL-1 和 TNF-α，IC50为 1 μM。
T22168	Vialinin A Terrestrin A	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	Vialinin A (Terrestrin A) (Terrestrin A) 是一种具有抗氧化性质的对三苯化合物。Vialinin A (Terrestrin A) 是 TNF-α，USP4, USP5 和 SENP1 特异性蛋白酶 1 的有效抑制剂。Vialinin A (Terrestrin A) 可用于自身免疫疾病和癌症研究。
T4062	CAY10602	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CAY10602 是一种SIRT1激活剂，可剂量依赖性地抑制 THP-1 细胞中脂多糖对 TNF-α 的 NF-κB 依赖性诱导。
T11886	LTβR-IN-1	Others; NF-κB; LTR	Immunology/Inflammation; NF-κB; Others
	LTβR-IN-1是一种有作用的、具有选择性的淋巴素β受体(LTβR)抑制剂。LTβR-IN-1 对TNF12A 的的 p52 的核易位抑制作用具有选择性，对 TNF-α 受体介导的 p65 的核易位无明显作用，却抑制受 TWEAK 或 Anti-LTβR 刺激的 p52 核易位，IC50为10 μM。LTβR-IN-1通过配体非依赖性方式实现对 NF-kB 信号通路的调节作用。
T7672	MD2-TLR4-IN-1	TLR	Immunology/Inflammation
	MD2-TLR4-IN-1 是一种骨髓分化蛋白 2/toll 样受体 4 (MD2-TLR4) 复合物抑制剂，能够抑制巨噬细胞 LPS 诱导的 TNF-α 和 IL-6 的表达，IC50值分别为 0.89 和 0.53 μM。
T24816	SP-100030 SP100030,SP 100030	NF-κB	NF-κB
	SP-100030 是一种有效的 NF-κB 和激活蛋白-1 (AP-1) 双抑制剂 (IC50 分别为 50 和 50 nM)。SP-10003 抑制 Jurkat 和其他T 细胞系产生的 IL-2、IL-8 和 TNF-α 的产生。SP-100030 降低小鼠胶原性关节炎 (CIA)。
T38294	4-Deoxypyridoxine hydrochloride	S1P Receptor	GPCR/G Protein
	4-Deoxypyridoxine hydrochloride 通过抑制 S1P 裂解酶 (SPL) 活性来抑制细胞内 S1P 的降解，与 S1P 一样，减少化学诱导的胰岛素瘤细胞系的细胞凋亡。
T79025	TNF-α-IN-10
	TNF-α-IN-10 (compound 8a) 作为IL-6与TNF-α的抑制剂，表现出抗炎活性。
T12985L	SPD304	TNF	Apoptosis
	SPD304 是一种选择性 TNF-α 抑制剂，可阻断 TNF 与其受体的相互作用。 SPD304 在体外抑制 TNF 受体 1 与 TNF-α 结合的 IC50 为 22 µM。
T30774	CC-3052 CC3052
	CC-3052 is a water-soluble, highly stable thalidomide analogue that is an effective inhibitor of HIV-1 expression and activation-induced TNF-α production. CC-3052 also inhibited PHA-induced and rTNF-α induced TNF-α transcription in PBMC, as well as TNF-α
T77097	Nerelimomab
	Nerelimomab (BAYX1351) 是一种抗TNF-α抗体。Nerelimomab 可用于脓毒症研究。
T78730	TNF-α-IN-11
	TNF-α-IN-11 (Compound 10)是一种TNF-α抑制剂, KD值为12.06 μM。该化合物通过结合TNF-α并阻断其诱发的caspase和NF-κB信号通路激活，来实现其抑制作用。其具体机制包括抑制IκBα磷酸化和NF κB p65的核转位，适用于研究TNF-α介导的自身免疫性疾病。
T38339	R-8507
	R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 μM, respectively, in an ELISA using A549 lung epithelial cells.{\|Gururaja2007\|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.
T76898	Adalimumab beta
	Adalimumab beta (ABP-501) 是一种抗 TNF-α单克隆抗体。Adalimumab beta 可用于类风湿性关节炎 (RA) 的研究。
T36486	Benpyrine
	Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. Benpyrine (5-20 μM; 14 hours; RAW264.7 cells) pretreatment results in a dose-dependent decrease in the phosphorylation of IκBα in RAW264.7 cells (stimulated with 10 ng/mL TNF-α or 1 μg/mL LPS). Benpyrine abo...
T37726	MMP-9 Inhibitor I
	MMP-9 inhibitor I is an inhibitor of matrix metalloproteinase-9 (MMP-9) that is selective over MMP-1 and MMP-13 (IC50s = 5, 1,050, and 113 nM, respectively). It also decreases the activity of TNF-α converting enzyme (TACE) in a dose-dependent manner (IC50 = 0.54 μM). MMP-9 inhibitor I decreases TNF-α secretion stimulated by LPS in BV-2 microglial cells when used at concentrations of 50 and 100 μM.
T36097	TNF-α-IN-2
	TNF-α-IN-2 is a highly potent and orally bioavailable inhibitor of tumor necrosis factor alpha (TNFα), exhibiting an IC50 of 25 nM in the HTRF assay. It exerts its inhibitory effects by inducing conformational changes in the TNFα trimer upon binding, resulting in disrupted signaling when the trimer interacts with TNFR1. TNF-α-IN-2 holds promise as a valuable tool for investigating the pathogenesis of rheumatoid arthritis[1].
T76988	Tanfanercept
	Tanfanercept (HL036337)，一种抗TNF-α单克隆抗体，在干眼症(DE)小鼠模型中能有效改善角膜糜烂。
T77114	Placulumab
	Placulumab (ART621)，一种针对TNF α的单克隆抗体，展现出抗炎作用，对于关节炎等炎症性疾病具备潜在治疗价值。
T76209	DSTYSLSSTLTLSK TFA
	DSTYSLSSTLTLSK TFA 是用于 Infliximab (Avakine) 定量检测的通用肽。Infliximab (Avakine) 是一种嵌合单克隆IgG1抗体，能特异性地结合到 TNF-α。
T79190	Homouridine	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Homouridine 是一种尿苷类似物，可作为中间体合成抑制剂 compound I（MMP-2 抑制剂, IC50=150 μM）。此外，Compound I (EP1338282) 也能抑制 TNF-α 与 TNF-αR1 的结合。
T81606	Onercept
	Onercept为重组可溶性人类肿瘤坏死因子-α p55受体，用于Crohn's disease研究。
T14312	Apratastat	MMP; TNF	Apoptosis; Proteases/Proteasome
	Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively[1].
T36401	DCVC
	DCVC inhibits pathogen-stimulated TNF-α in human extra placental membranes in vitro.Target: TNF-αin vitro: DCVC inhibits pathogen stimulated cytokine release from tissue punch cultures. DCVC (5-50 μM) significantly inhibits LTA-, LPS-, and GBS-stimulated cytokine release from tissue cultures as early as 4 h (P ≤ 0.05). In contrast, TCA (up to 500 μM) does not inhibit LTA-stimulated cytokine release from tissue punches. DCVC effects on LTA-stimulated and LPS-stimulated TNF-α release from tissue p...
T83048	Anti-inflammatory agent 64	ROS Kinase	Tyrosine Kinase/Adaptors
	Anti-inflammatory agent 64（compound 4b）能抑制IL-6和TNF-α的分泌，具备抗氧化及抗炎活性，无论在体内外均有效，能显著减轻足跖水肿。
T83051	Anti-inflammatory agent 61
	Anti-inflammatory agent 61 (Compound 5b)为一种高效抗炎化合物，能够降低LPS诱导的RAW 264.7细胞中的TNF-α表达，并可缓解APAP引起的HepG2细胞炎症。
T36091	LEESGGGLVQPGGSMK acetate
	LEESGGGLVQPGGSMK acetate is a proteolysis peptide found in Infliximab, a chimeric monoclonal IgG1 antibody. It serves as a component of Infliximab and can be employed for the quantitative analysis of this antibody. Infliximab is specifically designed to bind to TNF-α[1].
T62674	LSD1-IN-21
	LSD1-IN-21 是一种有效的、具有血脑屏障通透性的 LSD1 (赖氨酸特异性去甲基化酶-1) 抑制剂 (IC50: 0.956 μM)。LSD1-IN-21 能够明显减少促炎细胞因子 TNF-α，表现出良好的抗癌和抗炎效果。
T63919	IKKβ-IN-1
	IKKβ-IN-1 是一种有效的、口服具有活力的 IkappaB(IKK-β) 抑制剂 (IC50: 0.20 μM)。IKKβ-IN-1 能够减少抑制小鼠巨噬细胞中 PGE2和 TNF-α的产生。IKKβ-IN-1 对小鼠具有保护作用，使其免受感染性休克诱导的死亡。
T63088	NOD2 antagonist 1
	NOD2 antagonist 1 (compound 32) 是一种有效的、选择性的 NOD2 拮抗剂 (IC50: 5.23 μM)。NOD2 antagonist 1 在 THP-1 细胞，对 Muramyl dipeptide (MDP) 诱导的 IL-8 分泌表现出抑制作用。NOD2 antagonist 1 在 PBMCs 细胞，可以抑制 MDP 诱导的 IL-6、IL-10 和 TNF-α 的水平升高。
T60346	PDE4-IN-10
	PDE4-IN-10 (compound 7a) 是一种有效的PDE4抑制剂，其对PDE4B 的IC50值为 7.01 μM。PDE4-IN-10 表现出选择性，微粒体稳定性，对TNF-α有抑制作用，并且在体外无明显毒性。
T61794	LASSBio-1632
	LASSBio-1632 is a novel anti-asthmatic lead candidate that selectively inhibits PDE4A and PDE4D isoenzymes, leading to the suppression of airway hyper-reactivity (AHR) and TNF-α production in lung tissue. With high experimental BBB permeability, LASSBio-1632 (7j) efficiently crosses the blood-brain barrier through passive diffusion [1].
T80697	β5i-IN-1	Proteasome	Proteases/Proteasome; Ubiquitination
	β5i-IN-1 是 β5i 选择性抑制剂，具有 8.463 nM 的 IC50 值。该化合物能够诱导 TNF-α 和 IL-6 的释放，同时影响 NF-κB 的转录活性，适用于特发性肺纤维化研究。
T79256	DPP-4-IN-8
	DPP-4-IN-8 (compound 27) 是一种高效的选择性DPP4抑制剂，具有 0.96 μM 的 Ki。该化合物能够抑制 Caco-2 和 HepG-2 细胞中的 DPP4 二肽酶活性，并剂量依赖性地降低 TNF-α、IL-6 和 IL-1β 的表达水平[1]。
T36011	p38 MAP Kinase Inhibitor IV p38 MAPK Inhibitor IV
	p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells.
T61709	AMS-17
	AMS-17 is a potent NLRP3 inhibitor, which effectively suppresses microglia activation both in vitro and in vivo. Additionally, AMS-17 exhibits inhibitory effects on various cytokines, such as caspase-1, TNF-α, IL-1β, and inducible nitric oxide synthase (iNOS), in N9 cells. Given these properties, AMS-17 holds promise as a valuable tool for investigating inflammation-associated neurological disorders [1].
T72102	Glucocorticoid receptor modulator 1
	Glucocorticoid receptor modulator1 是一种高效且具有口服活性的 NF-κB 和 AP-1抑制剂，IC50分别为 9 nM 和 130 nM。Glucocorticoid receptor modulator1 可有效降低炎症因子 IL-6、IL-1β、TNF-α 的表达，可缓解小鼠皮炎。
T61302	Anti-inflammatory agent 17
	Anti-inflammatory agent 17 an orally active anti-inflammatory agent, demonstrates potent efficacy in inhibiting the release of IL-6 and TNF-α without causing cytotoxicity in in vitro experiments. Furthermore, in vivo studies confirm its anti-inflammatory activity. Given its attributes, Compound 17 holds promise for investigating Acute lung injury (ALI) [1].
T76963	Certolizumab pegol
	Certolizumab pegol (Certolizumab) 是经过重组和聚乙二醇化处理的人源化单克隆抗体抗原结合片段，它选择性地靶向并中和肿瘤坏死因子-α (TNF-α)。适用于类风湿关节炎和克罗恩病的研究领域。
T78508	Delmitide acetate RDP-58 acetate	IFNAR	Immunology/Inflammation
	Delmitide acetate (RDP58) 是一种 d-异构体十肽，具有抗炎活性和口服活性。该化合物能够抑制 TNF-α、IFN-γ 以及白细胞介素 (IL)-12 的生成，同时提高血红素加氧酶 1 的活性，可用于针对溃疡性结肠炎的研究。
T72017	6(5H)-Phenanthridinone
	6(5H)-Phenanthridinone is an inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2. It decreases radiation-induced PARP activity and proliferation of RDM4 murine lymphoma cells. 6(5H)-Phenanthridinone reduces NF-κB-induced transcription of the genes encoding TNF-α, IL-2, and IFN-γ in rat lymphocytes. In vivo, 6(5H)-phenanthridinone reduces spinal cord expression of inducible nitric oxide synthase (iNOS), IL-1β, TNF-α, IL-2, and IFN-γ and reduces disease score in a rat model of experimenta...
T78434	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA
	Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA 为基于荧光共振能量转移的多肽底物，通过裂解引起的荧光强度变化来确定其活性。
T35406	α-MSH TFA
	α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2α-MSH (100 pM) reducesS. aureuscolony formation andC. albicansgerm tube fo...

化合物

Cat.No: T13175

Target: TNF

Cat.No: T4328

Synonym: SIRT6-IN-1

Target: HBV, Sirtuin

Cat.No: T22698

Synonym: CU CPT 4a

Target: TLR

Cat.No: T77494

Target: TNF

Cat.No: T60054

Synonym: N-(3-chloro-4-hydroxyphenyl)-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide

Target: TNF

Cot inhibitor-1 hydrochloride

Cat.No: T10865L

Synonym: Cot inhibitor-1 hydrochloride(915365-57-0 Free base)

Target: TNF, MAPK

Cat.No: T9645

Synonym: N-(4-(3,5-bis(trifluoromethyl)phenoxy)phenyl)-2-fluoro-6-iodobenzamide

Target: TLR

Cat.No: T2367

Synonym: SKF86002

Target: p38 MAPK, TNF

Cat.No: T22168

Synonym: Terrestrin A

Target: DUB

Cat.No: T4062

Target: Sirtuin

Cat.No: T11886

Target: Others, NF-κB, LTR

Cat.No: T7672

Target: TLR

Cat.No: T24816

Synonym: SP100030,SP 100030

Target: NF-κB

4-Deoxypyridoxine hydrochloride

Cat.No: T38294

Target: S1P Receptor

Cat.No: T79025

Cat.No: T12985L

Target: TNF

Cat.No: T30774

Synonym: CC3052

Cat.No: T77097

Cat.No: T78730

Cat.No: T38339

Adalimumab beta

Cat.No: T76898

Cat.No: T36486

MMP-9 Inhibitor I

Cat.No: T37726

Cat.No: T36097

Cat.No: T76988

Cat.No: T77114

DSTYSLSSTLTLSK TFA

Cat.No: T76209

Cat.No: T79190

Target: Nucleoside Antimetabolite/Analog

Cat.No: T81606

Cat.No: T14312

Target: MMP, TNF

Cat.No: T36401

Anti-inflammatory agent 64

Cat.No: T83048

Target: ROS Kinase

Anti-inflammatory agent 61

Cat.No: T83051

LEESGGGLVQPGGSMK acetate

Cat.No: T36091

Cat.No: T62674

Cat.No: T63919

NOD2 antagonist 1

Cat.No: T63088

Cat.No: T60346

Cat.No: T61794

Cat.No: T80697

Target: Proteasome

Cat.No: T79256

p38 MAP Kinase Inhibitor IV

Cat.No: T36011

Synonym: p38 MAPK Inhibitor IV

Cat.No: T61709

Glucocorticoid receptor modulator 1

Cat.No: T72102

Anti-inflammatory agent 17

Cat.No: T61302

Certolizumab pegol

Cat.No: T76963

Delmitide acetate

Cat.No: T78508

Synonym: RDP-58 acetate

Target: IFNAR

6(5H)-Phenanthridinone

Cat.No: T72017

Mca-(endo-1a-Dap(Dnp))-TNF-Alpha (-5 to +6) amide (human) TFA

Cat.No: T78434

Cat.No: T35406

Cat. No.	Product Name	Target	Signaling Pathways
T5785	MALTOTETRAOSE Fujioligo 450,Amylotetraose,α-1,4-Tetraglucose,麦芽四糖	TNF; Endogenous Metabolite	Apoptosis; Metabolism
	Maltotetraose (Fujioligo 450) 能够作为生物流体中酶联测定淀粉酶特性的底物。
T3887	Rosarin	Others	Others
	Rosarin 是从玫瑰红景天中分离出来的肉桂醇糖苷。它抑制小鼠肾脏和大脑前额皮层中促炎因子 iNOS，IL-1β 和 TNF-α 的表达。它具有抗炎和神经保护作用。
TN6967	(R)-Isomucronulatol (-)-Isomucronulatol,2H-1-Benzopyran-7-ol	Apoptosis	Apoptosis
	(R)-Isomucronulatol (2H-1-Benzopyran-7-ol) 是一种可从黄芪、刺槐、虎杖和甘草叶片中提取得到的类黄酮，抑制BMSCs 在TNF-α微环境中的增殖和凋亡。(R)-Isomucronulatol 具有潜在的抗炎活性。
T6S1597	Mulberroside A 桑皮苷 A,桑皮苷A	TNF; Tyrosinase; Interleukin	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Mulberroside A 是桑中的一种主要活性成分，可降低TNF-α、IL-1β和IL-6的表达，抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化。它抑制蘑菇酪氨酸酶，具有抗炎和抗细胞凋亡作用。
TN6694	5,6-Benzoflavone β-Naphthoflavone,beta-NF	Antioxidant	oxidation-reduction
	5,6-Benzoflavone (β-Naphthoflavone) 是芳烃受体的外源配体，可破坏人肝癌 HepG2 细胞中的锌稳态。5,6-Benzoflavone (β-Naphthoflavone) 具有抗炎和抗氧化活性，抑制通过 AKT/Nrf-2/HO-1-NF-kappaB 信号转导轴，抑制 LPS 诱导的炎症，抑制TNF-α诱导的ICAM-1和VCAM-1表达，可用于研究神经退行性疾病。
T6S1579	Monotropein 水晶兰苷,Monotropeine	Others	Others
	Monotropein (Monotropeine) 是从Morinda officinalis 中获得，能够抑制硫酸葡聚糖硫酸钠诱导的结肠炎小鼠模型中炎性因子的表达。
T2768	Saikosaponin A 柴胡皂苷A,柴胡皂苷 A	NF-κB; Antibacterial; Liver X Receptor	Metabolism; Microbiology/Virology; NF-κB
	Saikosaponin A 是银柴胡中的主要活性成分，有抗炎活性，可上调 LXRα的表达。
T3763	Fumaric acid Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,反丁烯二酸,Donitic acid,Allomaleic acid,富马酸	Endogenous Metabolite	Metabolism
	Fumaric acid (2-Butenedioic acid) 与烟酸酶缺乏症相关，是癌症相关的内源性代谢物。
T4973	Paraxanthine 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE	Endogenous Metabolite	Metabolism
	Paraxanthine (1,7-dimethylxanthine) 是一种 caffeine 的代谢物，能够刺激Ryanodine 受体通道来抑制多巴胺能细胞的死亡。
T6S1495	Ginsenoside Rk3 人参皂苷Rk3,人参皂甙 Rk3	Others; NF-κB	NF-κB; Others
	Ginsenoside Rk3 是存在于 Panax notoginseng 的根中。它能够抑制 HepG2 细胞中 TNF-α 诱导的 NF-κB 转录活性，IC50=14.24±1.30 μM。
T6S0653	Linarin Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷	TNF; AChE	Apoptosis; Neuroscience
	Linarin (Acacetin-7-O-rutinoside) 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂，从薄荷花提取物中分离得到。
T2S0843	Negletein 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether	IL Receptor; TNF; NOS; Interleukin	Apoptosis; Immunology/Inflammation
	Negletein (7-O-Methylbaicalein) 一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突生长。它通过抑制TNF-α和IL-1β表现出抗炎活性，其 IC50值分别为 16.4 和 10.8 μM。它还具有抗菌、抗缺氧和抗阿尔茨海默病活性。
T5S0045	Isofraxidin 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶	MMP; ERK; p38 MAPK; TLR; COX	Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome
	Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分，抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞，抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达，还抑制TLR4/髓样分化蛋白 2 复合物的形成。
T4S2063	Tetrahydrocoptisine 人血草碱,STYLOPINE	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Tetrahydrocoptisine (STYLOPINE) 具有抑制炎症的有效作用。它通过抑制 NF-κB 信号通路对 LPS 诱导的 ALI 具有保护作用，这可能涉及抑制肺部炎症过程。它具有胃保护活性，归因于减少 NO 产生和调节促炎细胞因子，抑制中性粒细胞积累和 NF-κB 表达。它是一种活性抗炎成分，通过下调 NF-κB 活化、磷酸化 ERK1/2 和磷酸化-p38MAPK 信号通路抑制 TNF-α、IL-6 和 NO 的产生。
T6S0139	Neobavaisoflavone	Apoptosis; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Neobavaisoflavone 是一种从Psoralea corylifolia 的种子中分离出来的类黄酮。它具有抗炎，抗癌和抗氧化的作用。它在中至高浓度下可抑制 DNA 聚合酶，也可抑制血小板聚集。
T4S1521	1,4-Dicaffeoylquinic acid 1,4-二咖啡酰奎宁酸,洋蓟素	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	1,4-Dicaffeoylquinic acid 是一种苯丙素类物质，从苍耳子中获得，可以减少 LPS 诱导的 TNF-α 的生成，具有抗炎活性。
T2S2264	Linalool Linalol,(±)-Linalool,Phantol,沉香醇	Apoptosis; IL Receptor; TNF; Endogenous Metabolite; iGluR	Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Linalool (Linalol) 是存在芫荽等植物中的单萜类天然产物，是竞争性NMDA 受体拮抗剂，具有抗肿瘤和抗心脏毒性的作用。它通过激活 Nrf2 诱导抗氧化防御和通过抑制 NF-κB 减少炎症反应来保护其免受 LPS/GalN 诱导的肝损伤，具有镇痛、抗菌和抗炎的特性。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T4S1469	Cucurbitacin IIb 葫芦素IIB,雪胆素乙	Apoptosis; Others	Apoptosis; Others
	Cucurbitacin IIb 是一种雪胆中的活性成分。它阻碍 STAT3，JNK 和 Erk1/2 的磷酸化，提高 IκB 和 NF-κB (p65) 的磷酸化水平，抑制 NF-κB (p65) 的核转位，降低 IκBα 和 TNF-α 的 mRNA 水平。它能够诱导细胞凋亡，具有抗炎作用。
T6S1572	Sauchinone	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS，TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。
T6S2140	β-Anhydroicaritin Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素	MMP; Others; TNF; Interleukin	Apoptosis; Immunology/Inflammation; Others; Proteases/Proteasome
	β-Anhydroicaritin 是从乳香提取的一种天然产物，具有重要的生物学和药理学作用，如抗骨质疏松症，雌激素调节和抗肿瘤特性。它改善牙周组织的降解，抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。它抑制细胞内 Ca2+的升高，并显著降低 iNOS 蛋白的表达。
T3673	Mollugin 大叶茜草素,Rubimaillin	HER; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。
T81159	Sibiricine
	Sibiricine（Compound 8），一种从Corydalis crispa药用植物提取的异喹啉类生物碱，对于LPS诱导的THP-1细胞产生的TNF-α显示出显著的抗炎效果。
T35614	D-Trimannuronic acid
	D-Trimannuronic acid is an alginate oligomer that originates from seaweed. It can induce TNF-α secretion by mouse macrophage cell lines, making it valuable in pain and vascular dementia research [1][2][3].
TN1660	Ganoderic acid C1 灵芝酸 C1,灵芝酸C1	IL Receptor; TNF; NF-κB; MAPK; COX; HIV Protease; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome
	Ganoderic acid C1 是分离自 G. lucidum 中的天然产物，能够抑制小鼠巨噬细胞TNF-α 的生成。
T36513	Pyranonigrin A
	Pyranonigrin A is a fungal metabolite originally isolated from Aspergillus that has antioxidant activity. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH;) free radicals in a cell-free assay (IC50 = 132.9 μM). Pyranonigrin A (10 μM) suppresses TNF-α-induced expression of vascular cell adhesion molecule 1 (VCAM-1) in human umbilical vein endothelial cells (HUVECs).
T75694	Lacto-N-neotetraose
	Lacto-N-neotetraose (LNnT) 是一种内源性代谢物 (endogenous metabolite)。Lacto-N-neotetraose 可以抑制 TNF-α 诱导的未成熟上皮细胞中的IL-8分泌。Lacto-N-neotetraose 具有抗炎活性，可提高伤口愈合能力。
TN3219	7,8-Didehydrocimigenol	ERK; IκB/IKK; TNF; NF-κB; Akt; PPAR	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of VCAM-1 expression.
T37751	Streptazolin
	Streptazolin is a fungal metabolite originally isolated from S. viridochromogenes. It increases NF-κB activity when used at concentrations ranging from 60 to 130 μg/ml, at least in part, via PI3K signaling. Streptazolin enhances TNF-α secretion induced by LPS and enhances IL-8 secretion when used alone or in combination with LPS in THP-1 Blue cells.
T79977	Maceneolignan A
	Maceneolignan A，一种可从肉豆蔻（肉豆蔻科）假种皮分离的天然产品，有能力抑制RBL-2H3细胞内β-己糖胺酶释放，其IC50值为48.4 μM。同样，Maceneolignan A对抗原激活的RBL-2H3细胞中TNF-α释放的抑制作用，其IC50为63.7 μM。
TN3655	Cimiside E	ERK; TNF; ROS; Akt; PI3K; PKC; PPAR	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2, PI3K, and PKC are involved in this effect.Cimiside E may be an effective chemopreventive agen
T79970	Taxamairin B
	Taxamairin B是有效的抗炎化合物，能显著抑制LPS诱导的RAW264.7细胞中促炎因子(TNF-α, IL-1β和IL-6)表达及NO、ROS生成，并对LPS引起的急性肺损伤模型小鼠具有保护效果。
TN5593	Euphohelioscopin A
	Euphohelioscopin A, an activator of protein kinase C (PKC), it inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60. Euphohelioscopin A has anti-inflammary activity, it exhibits moderate inhibitory activity

天然产物

Cat.No: T5785

Synonym: Fujioligo 450,Amylotetraose,α-1,4-Tetraglucose,麦芽四糖

Target: TNF, Endogenous Metabolite

Cat.No: T3887

Target: Others

(R)-Isomucronulatol

Cat.No: TN6967

Synonym: (-)-Isomucronulatol,2H-1-Benzopyran-7-ol

Target: Apoptosis

Cat.No: T6S1597

Synonym: 桑皮苷 A,桑皮苷A

Target: TNF, Tyrosinase, Interleukin

5,6-Benzoflavone

Cat.No: TN6694

Synonym: β-Naphthoflavone,beta-NF

Target: Antioxidant

Cat.No: T6S1579

Synonym: 水晶兰苷,Monotropeine

Target: Others

Cat.No: T2768

Synonym: 柴胡皂苷A,柴胡皂苷 A

Target: NF-κB, Antibacterial, Liver X Receptor

Cat.No: T3763

Synonym: Lichenic acid,Fumarate,2-Butenedioic acid,Trans-Butenedioic acid,反丁烯二酸,Donitic acid,Allomaleic acid,富马酸

Target: Endogenous Metabolite

Cat.No: T4973

Synonym: 1,7-二甲基黄嘌呤,1,7-DIMETHYLXANTHINE

Target: Endogenous Metabolite

Ginsenoside Rk3

Cat.No: T6S1495

Synonym: 人参皂苷Rk3,人参皂甙 Rk3

Target: Others, NF-κB

Cat.No: T6S0653

Synonym: Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷

Target: TNF, AChE

Cat.No: T2S0843

Synonym: 黄芩素-7-甲醚,7-O-Methylbaicalein,Baicalein-7-methylether

Target: IL Receptor, TNF, NOS, Interleukin

Cat.No: T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶

Target: MMP, ERK, p38 MAPK, TLR, COX

Tetrahydrocoptisine

Cat.No: T4S2063

Synonym: 人血草碱,STYLOPINE

Target: ERK, p38 MAPK, NF-κB

Neobavaisoflavone

Cat.No: T6S0139

Target: Apoptosis, DNA/RNA Synthesis

1,4-Dicaffeoylquinic acid

Cat.No: T4S1521

Synonym: 1,4-二咖啡酰奎宁酸,洋蓟素

Target: HIV Protease

Cat.No: T2S2264

Synonym: Linalol,(±)-Linalool,Phantol,沉香醇

Target: Apoptosis, IL Receptor, TNF, Endogenous Metabolite, iGluR

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Cucurbitacin IIb

Cat.No: T4S1469

Synonym: 葫芦素IIB,雪胆素乙

Target: Apoptosis, Others

Cat.No: T6S1572

Target: ERK, p38 MAPK, NF-κB

β-Anhydroicaritin

Cat.No: T6S2140

Synonym: Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素

Target: MMP, Others, TNF, Interleukin

Cat.No: T3673

Synonym: 大叶茜草素,Rubimaillin

Target: HER, JAK

Cat.No: T81159

D-Trimannuronic acid

Cat.No: T35614

Ganoderic acid C1

Cat.No: TN1660

Synonym: 灵芝酸 C1,灵芝酸C1

Target: IL Receptor, TNF, NF-κB, MAPK, COX, HIV Protease, DNA/RNA Synthesis

Cat.No: T36513

Lacto-N-neotetraose

Cat.No: T75694

7,8-Didehydrocimigenol

Cat.No: TN3219

Target: ERK, IκB/IKK, TNF, NF-κB, Akt, PPAR

Cat.No: T37751

Maceneolignan A

Cat.No: T79977

Cat.No: TN3655

Target: ERK, TNF, ROS, Akt, PI3K, PKC, PPAR

Cat.No: T79970

Euphohelioscopin A

Cat.No: TN5593

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