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Search Results for " osteoporosis "

72

抑制剂 & 化合物

36

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T61269	Anti-osteoporosis agent-1
	Anti-osteoporosis agent-1 (comp 4aa) 作为一种高效的复制蛋白 A(RPA) 抑制剂，表现出其IC50值仅为18 μM。
T83032	Anti-osteoporosis agent-7
	Anti-osteoporosis agent-7 (Compound 133) 作为一种潜在的抗骨质疏松剂，对破骨细胞的形成展示了高度的抑制效果。
T78816	Anti-osteoporosis agent-4	NF-κB	NF-κB
	Anti-osteoporosis agent-4 (Compound 11h) 在生物医学领域中表现为有效抑制原代破骨细胞的分化，减弱RANKL诱导的破骨细胞生成，并展示出强抑制作用，具有 IC50 值为358.29 nM。此外，该化合物还能抑制关键的 PI3K/AKT 和 IκBα/NF-κB 信号通路激活，表明其在防治骨质疏松症中的潜在应用价值。
T10696	CB2 modulator 1	Cannabinoid Receptor	GPCR/G Protein
	CB2 modulator 1 是一种有效的 CB2 调节剂。可用于免疫疾病、骨质疏松症、炎症、肾缺血的研究。
T7469	Alendronic Acid alendronate,阿仑膦酸	Others	Others
	Alendronic Acid (alendronate) 是法呢基二磷酸合酶(FDPS)抑制剂，是一种双膦酸盐。它能够抑制破骨细胞介导的骨吸收，对绝经后骨质疏松症，恶性高钙血症和 Paget 病具有疗效。
T22703	CYM-5520 CYM 5520	S1P Receptor; LPL Receptor	GPCR/G Protein
	CYM-5520 是一种选择性的变构鞘氨醇 1-磷酸受体 2 (S1PR2) 激动剂，EC50为 480 nM。它可以在 S1PR2 受体中与 S1P 结合，可用于骨质疏松症研究。
T39508	KY-02327	Others	Others
	KY-02327 是 KY-02061的一种类似物，具有代谢稳定性。KY-02327是Dishevelled (Dvl)-CXXC5相互作用抑制剂。KY-02327激活Wnt/β-catenin 途径，从而促进成骨细胞分化。
T9917	Denosumab	RANKL/RANK	NF-κB
	Denosumab 是能够结合并抑制RANKL 受体激活因子的人单克隆抗体。它具有抗癌活性，可降髋部、低椎骨以及非椎骨骨折的风险。
T1210	Sodium etidronate 依替膦酸钠,Didronel	Phosphatase	Metabolism
	Sodium etidronate (Didronel) 是一种内源性 pyrophosphate 的合成治疗性 diphosphonate 类似物。作为称为 bisphosphonates 盐类药物家族的一员，etidronate disodium 与内源性 pyrophosphate 的不同之处在于其对酶水解的耐受性。该药剂吸附 hydroxyapatite 细胞并减少破骨细胞的数量，从而抑制异常骨吸收。 Etidronate 还可以直接刺激成骨细胞的骨形成。
T1850	Balicatib AAE581,巴利卡替	Cysteine Protease	Proteases/Proteasome
	Balicatib (AAE581) 是组织蛋白酶K 抑制剂，其对组织蛋白酶K 的抑制作用是组织蛋白酶B、L 和S 的抑制性的10到100倍。
T0308	Etidronic acid HEDPA,Etidronate,HEDP,羟乙磷酸	Apoptosis; Phosphatase; Others; HBV	Apoptosis; Metabolism; Microbiology/Virology; Others
	Etidronic acid (HEDP) 是一种影响钙代谢的二膦酸盐，抑制异位钙化并减缓骨吸收和骨转换，可应用于洗涤，水处理，化妆品和制药业。
T2334	Avanafil 阿伐那非,TA1790	PDE	Metabolism
	Avanafil (TA1790) 是一种高活性PDE-5抑制剂，IC50=5.2 nM，对PDE1，PDE6和PDE11活性较低。
T7839	Lasofoxifene Tartrate CP-336156,酒石酸拉索昔芬	Estrogen Receptor/ERR	Endocrinology/Hormones
	Lasofoxifene Tartrate (CP-336156) 是一种非甾体类的雌激素受体选择性调节剂 (SERM)。
T21460	Teriparatide acetate hPTH 1-34 (acetate salt),Parathar acetate,Forteo,醋酸立特帕肽	Others	Others
	Teriparatide acetate (Forteo) 是一种 PHT 激动剂，在 HEK293 细胞中的 IC50 为 2 nM。Teriparatide acetate 是一种重组形式的甲状旁腺激素。它是一种有效的合成代谢（即骨骼生长）剂，用于治疗某些形式的骨质疏松症。间歇使用特立帕肽比破骨细胞更能激活成骨细胞，从而导致骨骼整体增加。
T6374	Alfacalcidol Bondiol,Etalpha,阿法骨化醇,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol	Others	Others
	Alfacalcidol (Etalpha) 是一种维生素 D3 衍生物，是非选择性的维生素 D 受体活化剂，有用于骨质疏松研究的潜力。
T6739	Zoledronic Acid CGP-4244,CGP42446A,唑来膦酸,Zoledronate,CGP 42446,ZOL 446,Zometa	Apoptosis; Rho; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint
	Zoledronic Acid (ZOL 446) 是一种含氮二磷酸盐，能抑制破骨细胞的分化和凋亡，具有高效的抗骨质再吸收活性，也有抗癌作用。
T21299	Zoledronic acid monohydrate 唑来膦酸一水合物,zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate	Apoptosis; Others; Autophagy	Apoptosis; Autophagy; Others
	Zoledronic acid monohydrate (CGP 42446) 是一种含氮二磷酸盐，具有高效的抗骨质再吸收活性。它能抑制破骨细胞的分化和凋亡，有抗癌作用。
T29164	WY-47766 WY47766
	WY-47766, a proton pump inhibitor, is used potentially for the treatment of postmenopausal osteoporosis.
T19501	Pamidronate disodium pentahydrate	Others	Others
	Pamidronate disodium pentahydrate 能够强化骨骼、预防骨质疏松症。
T12846	SB-423562	CaSR	GPCR/G Protein
	SB-423562 是一种钙敏感受体 (CaSR) 拮抗剂，可用于骨质疏松症研究。
T24182	ISX-1 ISX 1	Others	Others
	ISX-1 抑制脂肪生成并促进成骨细胞生成。 ISX-1 可用于骨质疏松症和骨质减少症的研究。
T1599L	Ibandronate sodium 伊班膦酸钠,Boniva,Ibandronate sodium salt,Bondronat	HBV; Transferase	Metabolism; Microbiology/Virology
	Ibandronate sodium (Boniva) 是一种高活性的含氮二磷酸盐，可用于骨质疏松的研究。
TP1215	Abaloparatide TFA BA 058 TFA,Abaloparatide TFA (247062-33-5 free base),BIM 44058 TFA	Others	Others
	Abaloparatide TFA (BIM 44058 TFA) 是一种甲状旁腺激素相关蛋白 (PTHrP) 类似物药物，与相关药物特立帕肽一样用于治疗骨质疏松症。
T6539	Ibandronate sodium monohydrate Boniva monohydrate,Bondronat monohydrate,Ibandronate sodium,伊班膦酸钠单水合物,BM-210955,BM-21.0955,伊班膦酸钠一水合物,RPR-102289A	Apoptosis; Others	Apoptosis; Others
	Ibandronate sodium monohydrate (BM-210955) 是一种高活性的含氮二磷酸盐，可用于骨质疏松。
TP1040L	Calcitonin（salmon） Acetate(47931-85-1(free base)) Salmon calcitonin	CGRP Receptor	GPCR/G Protein; Neuroscience
	Calcitonin(salmon)Acetate (47931-85-1(free base))(Salmon calcitonin) 是一种钙调节激素，用于治疗绝经后至少 5 年的女性骨质疏松症。
T6373	Alendronate sodium hydrate G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,阿仑膦酸钠,G-704650 Adronat,Fosamax	Transferase	Metabolism
	Alendronate sodium hydrate (MK 217) 是 farnesyl diphosphate synthase 抑制剂(IC50:460 nM)。
TP1040	Calcitonin (salmon) 鲑降钙素,Calcitonin salmon,Salmon calcitonin	CGRP Receptor	GPCR/G Protein; Neuroscience
	Calcitonin (salmon) 是一种阿米林和卡西宁受体的双激动剂，是一种钙调节激素，能够刺激骨的生成并能抑制骨吸收。
T1041	Risedronate Sodium NE 58095 Sodium,Risedronic Acid Sodium,利塞膦酸钠,利赛膦酸钠	HBV; Transferase	Metabolism; Microbiology/Virology
	Risedronate Sodium (NE 58095 Sodium) 是一种双磷酸盐，对破骨细胞介导的骨吸收具有抑制作用。
T1641	Strontium ranelate Distrontium renelate,S12911,雷尼酸锶	Calcium Channel; CaSR	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	Strontium ranelate (S12911) 是抗骨质疏松的药物，能够抑制骨吸收，促进骨形成，进而促使正骨平衡。它还能够激活非骨骼细胞中的钙敏感受体 (CaSR)，进而促进肌醇 1，4，5-三磷酸的生成及丝裂原活化的蛋白激酶信号转导。
T67855	ISX-3	Others	Others
	ISX-3 是有效的促成骨剂和抗脂肪生成剂。ISX-3 可以增加 PPARγ 的表达。ISX-3 可用于研究骨质减少和骨质疏松症。
T21535	Parathyroid Hormone (1-34), bovine	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Parathyroid Hormone (1-34), bovine 是一种甲状旁腺激素 (PTH) 受体激动剂，是甲状旁腺激素的一部分。 Parathyroid Hormone (1-34), bovine 可用于研究骨质疏松症和甲状旁腺功能衰退。
T77567	BCPA	Others	Others
	BCPA 是一种无细胞毒性的 Pin1 调节剂。BCPA 可调节破骨细胞活化，减弱 Pin1 蛋白的减少，从而抑制 RANKL 诱导的破骨细胞发生的受体激活物。BCPA 用于研究骨质疏松。
T8436	Minodronic acid Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-,ONO-5920,YM-529	Apoptosis; P2X Receptor	Apoptosis; Membrane transporter/Ion channel; Neuroscience
	Minodronic acid(YM-529) 是一种 P2X2/3 受体拮抗剂，具有抗癌活性，可直接或间接的抑制癌细胞增殖，诱导细胞凋亡。Minodronic-acid 对各种类型的癌细胞的转移具有抑制作用。Minodronic-acid 可用于研究骨质疏松。
T60554	Schnurri-3 inhibitor-1	Others	Others
	Schnurri-3 inhibitor-1 是有效的 schnurri-3 抑制剂，schnurri-3是成人骨形成的重要调节因子。在成骨细胞系 Shn3FFL 中，Schnurri-3 inhibitor-1 通过 EF1alpha 启动子抑制 Shn3 蛋白表达 (AC50= 2.09 μM)。Schnurri-3 inhibitor-1 可用于骨质疏松症相关的研究。
T111959	IFB-088 acetate
	IFB-088 acetate 是一种苄基胍衍生物，可用于治疗与PPP1R15A 途径相关并与蛋白质错误折叠应激相关的疾病和癌症，如tau 病、突触核蛋白病、多谷氨酰胺和多丙氨酸疾病、白质营养不良、囊性纤维化、多发性硬化症、溶酶体储存障碍、淀粉样变性疾病、炎症、代谢障碍、心血管疾病、骨质疏松症、神经系统创伤等等。
T31944	Glutamine monofluorophosphate L-Glutamine monofluorophosphate,G-MFP
	Glutamine monofluorophosphate is used during the fluorotherapy of osteoporosis.
T28870	Strontium Malonate NBS-101,NBS 101,NBS101
	Strontium Malonate, a calcium-sensing receptor agonist, is used potentially for the treatment of postmenopausal osteoporosis.
T25700L	Levormeloxifene fumarate
	Levormeloxifene fumarate is an osteoporosis drug and selective estrogen receptor modulator (SERM).
T70305	Zoledronate trisodium hydrate
	Zoledronate trisodium is a Bone Resorption Inhibitor and Osteoporosis Therapy Adjunct
T27825	LG190178 LG-190178,LG 190178
	LG190178, a vitamin D receptor (VDR) ligand, is a therapeutic agent used for the treatment of psoriasis, osteoporosis, and secondary hyperparathyroidism.
T26041	Ranelic acid
	Ranelic acid is an organic acid capable of chelating metal cations. Strontium ranelate, the strontium salt of Ranelic acid, is utilized to treat osteoporosis and increase bone mineral density.
T11914	LY88074 Trimethyl ether	Others	Others
	LY88074 Trimethyl ether is useful for inhibiting various conditions associated with estrogen deprivation syndrome, such as osteoporosis and hyperlipidemia.
T31624	Encaleret JIT305,JIT 305
	Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.
T69778	iso-Dehydrozingerone
	iso-Dehydrozingerone is a novel osteoclastogenesis inhibitor, preventing ovariectomy-induced osteoporosis in ddY mice.
T15749	LGD-2226	Androgen Receptor	Endocrinology/Hormones
	LGD-2226 is a selective and orally active androgen receptor modulator (EC50: 0.2 nM, Ki: 1.5 nM for the human androgen receptor). LGD-2226 can be used for muscle wasting, osteoporosis, and sexual dysfunction.
T19305	Eldecalcitol-d6	Others	Others
	Eldecalcitol is an orally active analogue of active vitamin D used in the treatment of osteoporosis. Eldecalcitol-d6 is the deuterium labeled Eldecalcitol.
T11913	LY88074 Methyl ether	Others	Others
	LY88074 Methyl ether is effective in inhibiting conditions associated with estrogen deprivation syndrome, such as osteoporosis and hyperlipidemia, which occur due to various estrogen-deficient states.
T15206	Eldecalcitol 艾地骨化醇,ED-71,2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3	Others	Others
	Eldecalcitol possesses a potent inhibitory effect on bone resorption and induces a significant increase in bone mineral density. Eldecalcitol is an orally active analogue of active vitamin D. It also is used in the treatment of osteoporosis .
T16394	ONO-5334	Cysteine Protease	Proteases/Proteasome
	ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 has the potential for the study of osteoporosis.
TP1027	Calcitonin, eel TFA (57014-02-5 free base) Thyrocalcitonin eel (TFA),Calcitonin, eel TFA
	Calcitonin,eel TFA is a thyroid hormone polypeptide that can regulate calcium homeostasis and is widely used in the study of postmenopausal osteoporosis.

化合物

Anti-osteoporosis agent-1

Cat.No: T61269

Anti-osteoporosis agent-7

Cat.No: T83032

Anti-osteoporosis agent-4

Cat.No: T78816

Target: NF-κB

CB2 modulator 1

Cat.No: T10696

Target: Cannabinoid Receptor

Alendronic Acid

Cat.No: T7469

Synonym: alendronate,阿仑膦酸

Target: Others

Cat.No: T22703

Synonym: CYM 5520

Target: S1P Receptor, LPL Receptor

Cat.No: T39508

Target: Others

Cat.No: T9917

Target: RANKL/RANK

Sodium etidronate

Cat.No: T1210

Synonym: 依替膦酸钠,Didronel

Target: Phosphatase

Cat.No: T1850

Synonym: AAE581,巴利卡替

Target: Cysteine Protease

Cat.No: T0308

Synonym: HEDPA,Etidronate,HEDP,羟乙磷酸

Target: Apoptosis, Phosphatase, Others, HBV

Cat.No: T2334

Synonym: 阿伐那非,TA1790

Target: PDE

Lasofoxifene Tartrate

Cat.No: T7839

Synonym: CP-336156,酒石酸拉索昔芬

Target: Estrogen Receptor/ERR

Teriparatide acetate

Cat.No: T21460

Synonym: hPTH 1-34 (acetate salt),Parathar acetate,Forteo,醋酸立特帕肽

Target: Others

Cat.No: T6374

Synonym: Bondiol,Etalpha,阿法骨化醇,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol

Target: Others

Zoledronic Acid

Cat.No: T6739

Synonym: CGP-4244,CGP42446A,唑来膦酸,Zoledronate,CGP 42446,ZOL 446,Zometa

Target: Apoptosis, Rho, Autophagy

Zoledronic acid monohydrate

Cat.No: T21299

Synonym: 唑来膦酸一水合物,zoledronate,ZOL 446,CGP 42446,CGP42446A,Zoledronic acid hydrate

Target: Apoptosis, Others, Autophagy

Cat.No: T29164

Synonym: WY47766

Pamidronate disodium pentahydrate

Cat.No: T19501

Target: Others

Cat.No: T12846

Target: CaSR

Cat.No: T24182

Synonym: ISX 1

Target: Others

Ibandronate sodium

Cat.No: T1599L

Synonym: 伊班膦酸钠,Boniva,Ibandronate sodium salt,Bondronat

Target: HBV, Transferase

Abaloparatide TFA

Cat.No: TP1215

Synonym: BA 058 TFA,Abaloparatide TFA (247062-33-5 free base),BIM 44058 TFA

Target: Others

Ibandronate sodium monohydrate

Cat.No: T6539

Synonym: Boniva monohydrate,Bondronat monohydrate,Ibandronate sodium,伊班膦酸钠单水合物,BM-210955,BM-21.0955,伊班膦酸钠一水合物,RPR-102289A

Target: Apoptosis, Others

Calcitonin（salmon） Acetate(47931-85-1(free base))

Cat.No: TP1040L

Synonym: Salmon calcitonin

Target: CGRP Receptor

Alendronate sodium hydrate

Cat.No: T6373

Synonym: G-704650,Alendronate,MK 217,Alendronate sodium trihydrate,阿仑膦酸钠,G-704650 Adronat,Fosamax

Target: Transferase

Calcitonin (salmon)

Cat.No: TP1040

Synonym: 鲑降钙素,Calcitonin salmon,Salmon calcitonin

Target: CGRP Receptor

Risedronate Sodium

Cat.No: T1041

Synonym: NE 58095 Sodium,Risedronic Acid Sodium,利塞膦酸钠,利赛膦酸钠

Target: HBV, Transferase

Strontium ranelate

Cat.No: T1641

Synonym: Distrontium renelate,S12911,雷尼酸锶

Target: Calcium Channel, CaSR

Cat.No: T67855

Target: Others

Parathyroid Hormone (1-34), bovine

Cat.No: T21535

Target: Thyroid hormone receptor(THR)

Cat.No: T77567

Target: Others

Minodronic acid

Cat.No: T8436

Synonym: Phosphonicacid,(1-hydroxy-2-imidazo(1,2-a)pyridin-3-ylethylidene)bis-,ONO-5920,YM-529

Target: Apoptosis, P2X Receptor

Schnurri-3 inhibitor-1

Cat.No: T60554

Target: Others

IFB-088 acetate

Cat.No: T111959

Glutamine monofluorophosphate

Cat.No: T31944

Synonym: L-Glutamine monofluorophosphate,G-MFP

Strontium Malonate

Cat.No: T28870

Synonym: NBS-101,NBS 101,NBS101

Levormeloxifene fumarate

Cat.No: T25700L

Zoledronate trisodium hydrate

Cat.No: T70305

Cat.No: T27825

Synonym: LG-190178,LG 190178

Cat.No: T26041

LY88074 Trimethyl ether

Cat.No: T11914

Target: Others

Cat.No: T31624

Synonym: JIT305,JIT 305

iso-Dehydrozingerone

Cat.No: T69778

Cat.No: T15749

Target: Androgen Receptor

Eldecalcitol-d6

Cat.No: T19305

Target: Others

LY88074 Methyl ether

Cat.No: T11913

Target: Others

Cat.No: T15206

Synonym: 艾地骨化醇,ED-71,2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3

Target: Others

Cat.No: T16394

Target: Cysteine Protease

Calcitonin, eel TFA (57014-02-5 free base)

Cat.No: TP1027

Synonym: Thyrocalcitonin eel (TFA),Calcitonin, eel TFA

Cat. No.	Product Name	Target	Signaling Pathways
T83033	Anti-osteoporosis agent-2
	Anti-osteoporosis agent-2 (Compound 10)为抗骨质疏松剂，能抑制RANKL诱导的破骨细胞分化。
TN1124	Neoeriocitrin	AChE	Neuroscience
	Neoeriocitrin 是一种有效的乙酰胆碱酯酶抑制剂，分离于自百日草，在 MC3T3-E1 中显示出对增殖和成骨分化的活性。
T5S1172	Tiliroside 银椴甙,Tribuloside,银椴苷；椴树苷	Antioxidant	oxidation-reduction
	Tiliroside (Tribuloside) 是糖苷类黄酮，是 α-淀粉酶的非竞争性抑制剂(Ki:84.2 μM)。它抑制胃肠道中碳水化合物的消化和葡萄糖的吸收，具有抗糖尿病作用。
T3408	Syringin Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine,紫丁香苷	NOS; Autophagy	Autophagy; Immunology/Inflammation
	Syringin (eleutheroside-b) 是欧丁香中的一种苯丙素类天然产物，通过抑制自噬来防止压力超载引起的心肌肥厚，具有抗肿瘤、抗增殖、抗骨质疏松、免疫调节和血小板聚集抑制作用。
TN7036	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) 是一种从玛卡中分离得到的玛卡酰胺。它能够激活典型的Wnt/β‐catenin 信号通路，诱导间充质干细胞成骨分化和随后的骨形成，可用于研究骨质疏松症。
T3906	Epimedin A	Others	Others
	Epimedin A 是一种提取自草本淫羊藿中的天然化合物。
TQ0172	2''-O-Rhamnosylicariside II	Others	Others
	2''-O-Rhamnosylicariside II 是天然来源的黄酮类糖苷化合物，可能对改善绝经后骨质疏松有益处。
TN1076	Oleonuezhenide	Others	Others
	Oleonuezhenide 分离自 Fructus Ligustri Lucidi 中，具有神经保护活性。
T6S2146	Epimedin B 朝藿定B,Epmedin B	Others	Others
	Epimedin B (Epmedin B) 是一种天然活性成分，来自淫羊藿，据报道其就有抗骨质疏松症的潜能。
T2O2798	D-(+)-Trehalose Ergot Sugar,D-Trehalose,Mycose,D-(+)-Trehalose Anhydrous,D-海藻糖,Trehalose	Others; Endogenous Metabolite	Metabolism; Others
	D-(+)-Trehalose (Mycose) 来源于自Saccharomyces cerevisiae，常用作食品成分和药物赋形剂。
T3130	Testosterone phenylpropionate Testosterone hydrocinnamate,苯丙酸睾酮,Retandrol,Testosterone 17-phenylpropionate	Others	Others
	Testosterone phenylpropionate (Testosterone 17-phenylpropionate) 是一种长效雄激素。d3-Testosterone phenylpropionate 可用作内标物。
T7106	Menaquinone-4 四烯甲萘醌,Vitamin K2,Menaquinone K4	Others; Endogenous Metabolite	Metabolism; Others
	Menaquinone-4 (Vitamin K2) 是维生素 K 的一种，用作止血剂，有潜力用于骨质疏松的研究。
T3396	Baohuoside I Icariside-II,宝藿苷I,Icariin-II,宝藿苷 I	Apoptosis; CXCR	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation
	Baohuoside I (Icariside-II) 是从朝鲜淫羊藿中得到的一种黄酮类天然产物，是CXCR4抑制剂，抑制 CXCR4 的表达，诱导凋亡，具有抗肿瘤活性。
T5751	Tigogenin	Others	Others
	Tigogenin 是甾体皂甙元，普遍用于甾体类药物的合成。它能够阻碍小鼠骨髓基质细胞脂肪细胞分化，促使成骨细胞的分化。
T3397	Epmedin C 淫羊霍定C,Baohuoside-VI,Epimedin C	Others	Others
	Epmedin C (Baohuoside-VI) 是天然化合物，在切除卵巢的小鼠体内与雌性激素作用相似。
T6S2252	Sweroside	Others	Others
	Sweroside 是分离自Lonicera japonica 中，具有细胞保护、抗骨质疏松和保护肝脏活性。
T8709	Nandrolone phenylpropionate Nandrolone phenpropionate,苯丙酸诺龙	Androgen Receptor	Endocrinology/Hormones
	Nandrolone phenylpropionate (Nandrolone phenpropionate) 是一种合成代谢类固醇，是一种 19-nortestosterone 的衍生物。它能够促进蛋白质合成，用于缓解组织分解代谢，可以用于骨质疏松症和特纳综合征的研究。
TN7242	5-Hydroxyvanillin 3,4-Dihydroxy-5-methoxybenzaldehyde	Antifungal	Microbiology/Virology
	5-Hydroxyvanillin (3,4-Dihydroxy-5-methoxybenzaldehyde) 可从籼稻中就分离得到对金黄色葡萄球菌具有抑制作用，可用于治疗和预防骨质疏松症。
TN6900	Reptoside	Others	Others
	Reptoside 可从杜仲和 Ajuga chamaepitys （L.） Schreb 根部和地上部分中提取，是杜仲治疗骨质疏松症的活性环烯醚萜苷之一。
TJS0856	Dalbergin 黄檀素,6-Hydroxy-7-Methoxy-4-Phenylcoumarin	Others	Others
	Dalbergin (6-Hydroxy-7-Methoxy-4-Phenylcoumarin) 是一种 Dalbergia Sissoo Linn. knot wood 提取物的成分。它具有强大的抗氧化活性。
T1549	Raloxifene hydrochloride LY156758 hydrochloride,盐酸雷洛昔芬,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl	Estrogen Receptor/ERR; Others; MAO; Estrogen/progestogen Receptor; Autophagy	Autophagy; Endocrinology/Hormones; Metabolism; Neuroscience; Others
	Raloxifene hydrochloride (LY156758 hydrochloride) 是一种选择性且可口服的雌激素受体调节剂，用于预防绝经后妇女的骨质疏松症。它对骨骼和胆固醇代谢具有雌激素激动作用，但对乳腺和子宫组织具有完全的雌激素拮抗作用。
T3S0364	L-Arginine L-精氨酸,L-Arg,(S)-(+)-Arginine	IL Receptor; Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism
	L-Arginine (L-Arg) 是内皮型一氧化氮合酶(eNOS) 的底物。L-Arginine 通过阳离子氨基酸转运体家族转运到血管平滑肌细胞，并被代谢成一氧化氮、多胺或 L-脯氨酸。
T2768	Saikosaponin A 柴胡皂苷A,柴胡皂苷 A	NF-κB; Antibacterial; Liver X Receptor	Metabolism; Microbiology/Virology; NF-κB
	Saikosaponin A 是银柴胡中的主要活性成分，有抗炎活性，可上调 LXRα的表达。
T7190	Actein	Apoptosis; Akt; JNK; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Actein 是从升麻的根茎中分离的一种三萜糖苷，通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖，诱导自噬和凋亡。
TN5888	Toddaculin	Others	Others
	Toddaculin 是一种天然香豆素，抑制过度的破骨细胞活性并增强成骨细胞分化和矿化。它可诱导白血病细胞分化和凋亡，具有抗炎活性。
T6S2099	Geraniin	Antioxidant; TNF	Apoptosis; oxidation-reduction
	Geraniin 是一种肿瘤坏死因子α释放抑制剂，其IC50值为 43 μM，具有抗肿瘤、抗炎和抗高血糖活性。
T3673	Mollugin 大叶茜草素,Rubimaillin	HER; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。
T6S1559	Aurantio-obtusin	Others	Others
	Aurantio-obtusin 是从决明子中分离出的蒽醌类化合物，具有抗炎、抗凝血、抗氧化、抗高血压的活性。它能抑制 IgE 介导的肥大细胞和过敏模型中的过敏反应，具有研究过敏相关疾病的潜力。在大鼠中，它通过内皮细胞 PI3K/AKT/ eNOS 依赖信号通路放松全身动脉，是潜在的新型血管扩张剂。
TMA0132	Dihydrophaseic acid	Others	Others
	Dihydrophaseic acid 3'-O-b-D-glucopyranoside (D3G) can increase the proliferation and differentiation of osteoblast cells and enhance bone formation, suggests that D3G may be a good candidate for the treatment of osteoporosis.
TN6568	Glycinol
	Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity.
T81761	Morusignin L
	Morusignin L为一种表现出抗骨质疏松症效应的化学物质。
T39445	Korepimedoside C Epimedin I,朝藿苷丙
	Korepimedoside C, also known as Epimedin I, is a flavonol glycoside derived from the aerial parts of Epimedium koreanum Nakai. Epimedium koreanum Nakai is a renowned Chinese herbal medicine that has been extensively studied for its potential in addressing impotence, osteoporosis, immune suppression, and cardiovascular diseases.
TN3753	Dalbergioidin	Tyrosinase; ROS; Akt; PI3K; TGF-beta/Smad	Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Dalbergioidin protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, suggests that it may be useful in bone metabolism diseases, particularly osteoporosis. Dalbergioidin also ameliorates doxorubicin-induced ...
TN1431	Baohuoside VII 宝藿苷,宝藿苷VII	Others	Others
	Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VII in vivo exhibits significant anti
TN3144	6,4'-Dihydroxy-7-methoxyflavanone 檀木	ERK; IL Receptor; Antioxidant; TNF; NF-κB; MAPK; Prostaglandin Receptor; JNK; Autophagy	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; oxidation-reduction
	6,4'-Dihydroxy-7-methoxyflavanone 是一种从 Dalbergia odorifera T. Chen (Leguminosae) 的心材中分离出来的生物活性化合物，具有抗氧化、抗炎和神经保护作用。 6,4'-二羟基-7-甲氧基黄烷酮可用于治疗破骨性骨病如骨质疏松症、类风湿性关节炎和牙周病的研究。
TN4334	Isotaxiresinol	TNF	Apoptosis
	Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. Isotaxiresinol ma

天然产物

Anti-osteoporosis agent-2

Cat.No: T83033

Cat.No: TN1124

Target: AChE

Cat.No: T5S1172

Synonym: 银椴甙,Tribuloside,银椴苷；椴树苷

Target: Antioxidant

Cat.No: T3408

Synonym: Lilacin,Syringoside,eleutheroside-b,Methoxyconiferine,紫丁香苷

Target: NOS, Autophagy

N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide

Cat.No: TN7036

Synonym: (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14

Target: Wnt/beta-catenin

Cat.No: T3906

Target: Others

2''-O-Rhamnosylicariside II

Cat.No: TQ0172

Target: Others

Cat.No: TN1076

Target: Others

Cat.No: T6S2146

Synonym: 朝藿定B,Epmedin B

Target: Others

D-(+)-Trehalose

Cat.No: T2O2798

Synonym: Ergot Sugar,D-Trehalose,Mycose,D-(+)-Trehalose Anhydrous,D-海藻糖,Trehalose

Target: Others, Endogenous Metabolite

Testosterone phenylpropionate

Cat.No: T3130

Synonym: Testosterone hydrocinnamate,苯丙酸睾酮,Retandrol,Testosterone 17-phenylpropionate

Target: Others

Cat.No: T7106

Synonym: 四烯甲萘醌,Vitamin K2,Menaquinone K4

Target: Others, Endogenous Metabolite

Cat.No: T3396

Synonym: Icariside-II,宝藿苷I,Icariin-II,宝藿苷 I

Target: Apoptosis, CXCR

Cat.No: T5751

Target: Others

Cat.No: T3397

Synonym: 淫羊霍定C,Baohuoside-VI,Epimedin C

Target: Others

Cat.No: T6S2252

Target: Others

Nandrolone phenylpropionate

Cat.No: T8709

Synonym: Nandrolone phenpropionate,苯丙酸诺龙

Target: Androgen Receptor

5-Hydroxyvanillin

Cat.No: TN7242

Synonym: 3,4-Dihydroxy-5-methoxybenzaldehyde

Target: Antifungal

Cat.No: TN6900

Target: Others

Cat.No: TJS0856

Synonym: 黄檀素,6-Hydroxy-7-Methoxy-4-Phenylcoumarin

Target: Others

Raloxifene hydrochloride

Cat.No: T1549

Synonym: LY156758 hydrochloride,盐酸雷洛昔芬,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl

Target: Estrogen Receptor/ERR, Others, MAO, Estrogen/progestogen Receptor, Autophagy

Cat.No: T3S0364

Synonym: L-精氨酸,L-Arg,(S)-(+)-Arginine

Target: IL Receptor, Endogenous Metabolite, NO Synthase

Cat.No: T2768

Synonym: 柴胡皂苷A,柴胡皂苷 A

Target: NF-κB, Antibacterial, Liver X Receptor

Cat.No: T7190

Target: Apoptosis, Akt, JNK, Autophagy

Cat.No: TN5888

Target: Others

Cat.No: T6S2099

Target: Antioxidant, TNF

Cat.No: T3673

Synonym: 大叶茜草素,Rubimaillin

Target: HER, JAK

Aurantio-obtusin

Cat.No: T6S1559

Target: Others

Dihydrophaseic acid

Cat.No: TMA0132

Target: Others

Cat.No: TN6568

Cat.No: T81761

Korepimedoside C

Cat.No: T39445

Synonym: Epimedin I,朝藿苷丙

Cat.No: TN3753

Target: Tyrosinase, ROS, Akt, PI3K, TGF-beta/Smad

Cat.No: TN1431

Synonym: 宝藿苷,宝藿苷VII

Target: Others

6,4'-Dihydroxy-7-methoxyflavanone

Cat.No: TN3144

Synonym: 檀木

Target: ERK, IL Receptor, Antioxidant, TNF, NF-κB, MAPK, Prostaglandin Receptor, JNK, Autophagy

Cat.No: TN4334

Target: TNF

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