89
7
3
2
20
Cat. No. | Product Name | ||
---|---|---|---|
L2192 | 抗胰腺癌化合物库 | 2238 compounds | |
2238 种与胰腺癌相关的化合物,可以用于高通量和高内涵筛选; | |||
L1610 | FDA 上市激酶抑制剂库 | 263 compounds | |
263种靶向激酶的上市药物集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选; | |||
L1600 | 激酶抑制剂库 | 2700 compounds | |
2700 种激酶抑制剂/调节剂的独特集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
CL0091 |
MEK inhibitor kit
MEK inhibitor kit |
||
CL0109 |
Ras inhibitor kit
Ras inhibitor kit |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T28012 |
MEK-IN-4
|
MEK | MAPK |
MEK-IN-4 是一种 MEK 抑制剂,可用于研究炎症性疾病和癌症。 | |||
T6843 |
GDC-0623
G-868,GDC0623,RG 7421,MEK inhibitor 1 |
Apoptosis; MEK | Apoptosis; MAPK |
GDC-0623 (RG 7421) 是一种 ATP 竞争性的MEK1抑制剂,Ki 值为 0.13 nM。它对 A375 细胞中 BRAFV600E 的 EC50值为 7 nM,而对 HCT116 细胞中 KRAS (G13D)的 EC50值为 42 nM。 | |||
T11993 |
MEK inhibitor
|
MEK | MAPK |
MEK inhibitor is a potent MEK inhibitor with antitumor potency. | |||
T10675 |
MEK-IN-1
|
MEK | MAPK |
MEK-IN-1 is a MEK inhibitor. | |||
T73364 |
MEK-IN-5
|
||
MEK-IN-5 是一种有效的 MEK 抑制剂和 NO 供体。MEK-IN-5 以剂量和时间依赖性方式显著降低 pMEK 和 pERK 的表达水平。MEK-IN-5 诱导 MDA-MB-231 细胞凋亡 (apoptosis)。 | |||
T74361 | MEK/PI3K-IN-2 | ||
MEK/PI3K-IN-2 (compound 6s) 是一种有效的 MEK/PI3K 抑制剂,其 IC50值分别为 352 nM (MEK1), 107 nM (PI3Kα), 和 137 nM (PI3Kδ)。MEK/PI3K-IN-2 抑制 pAKT 和 pERK1/2 水平。MEK/PI3K-IN-2 对肿瘤细胞具有抗增殖活性。 | |||
T79047 | MEK-IN-6 | ERK | MAPK |
MEK-IN-6(Example 69)是一种针对MEK的抑制剂,在A375细胞中有效抑制ERK1/2(THR202/Tyr204)的磷酸化,其IC50值为2 nM。此化合物主要应用于癌症研究领域。 | |||
T2508 |
Binimetinib
ARRY-438162,ARRY-162,MEK162 |
MEK; Autophagy | Autophagy; MAPK |
Binimetinib (ARRY-162) 是一种可口服的选择性 MEK1/2抑制剂,抑制MEK 的IC50为 12 nM。 | |||
T74360 |
MEK/PI3K-IN-1
|
||
MEK/PI3K-IN-1(compound 6r)是一种高效的MEK/PI3K抑制剂,IC50值为124 nM(MEK1)、130 nM(PI3Kα)及236 nM(PI3Kδ)。该化合物能够降低pAKT和pERK1/2的活性,并展现对肿瘤细胞的抗增殖作用。 | |||
T79048 | MEK-IN-6 hydrate | MEK | MAPK |
MEK-IN-6 hydrate(compound 69)为MEK抑制剂,其对A375细胞展现出强效性,IC50仅为2 nM。 | |||
T40206 |
MEK4 inhibitor-1
MEK4 inhibitor-1 |
||
MEK4 inhibitor-1 is a newly developed compound specifically designed to inhibit the activity of MEK4, a key enzyme involved in pancreatic adenocarcinoma, with an IC 50 value of 61 nM. | |||
T6152 |
PD318088
|
MEK | MAPK |
PD318088 是非 ATP 竞争性的MEK1/2变构抑制剂,是 PD184352 的结构类似物。它在MEK1 活性位点与 ATP 结合位点相邻的区域与 ATP 同时结合,可用于癌症研究。 | |||
T6785 |
BI-847325
|
Apoptosis; MEK; Aurora Kinase | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK |
BI847325是MEK 和极光激酶 (AK)的一种选择性双重抑制剂, 对人类MEK2和AK-C 的IC50值分别为4和15 nM。 | |||
T6692 |
TAK-733
TAK733,TAK 733 |
MEK | MAPK |
TAK-733 是选择性 MEK 抑制剂,IC50为 3.2 nM。 | |||
T2708 |
SL327
SL 327,SL-327 |
MEK; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; MAPK |
SL327 是能通过血脑屏障运输的选择性 MEK1/2 抑制剂,IC50 分别为 0.18 和 0.22 μM。 | |||
T21295 |
BIX02189
BIX 02189 |
ERK; MEK | MAPK |
BIX02189 是一种有效的选择性 MEK5 和 ERK5 抑制剂,IC50分别为 1.5 和 59 nM。 | |||
T21635 |
PD184161
|
MEK | MAPK |
PD 184161 是一种口服有效的,时间和浓度依赖的 MEK 抑制剂,IC50为10-100 nM。它诱导抑郁样行为,抑制细胞增殖并诱导细胞凋亡。 | |||
T2623 |
PD98059
PD 98059 |
ERK; Aryl Hydrocarbon Receptor; MEK; Autophagy | Autophagy; Immunology/Inflammation; MAPK |
PD98059 是一种 MEK 抑制剂,抑制 MEK1 和 MEK2 (IC50=2/50 μM),具有非 ATP 竞争性。PD98059 也是一种 AHR 的配体而起拮抗作用。PD98059 可以抑制细胞自噬。 | |||
T7610 |
GW284543
UNC10225170 |
MEK | MAPK |
GW284543 (UNC10225170) 是一个选择性的MEK5抑制剂,可降低 pERK5,并下调内源性 MYC 蛋白。 | |||
T2443 |
CI-1040
PD 184352 |
Apoptosis; MEK | Apoptosis; MAPK |
CI-1040 (PD 184352) 是一种有口服活性的高度特异性MEK 小分子抑制剂,对 MEK1 的IC50值为 17 nM 。 | |||
T6971 |
Ro 5126766
CH5126766,Avutometinib,VS-6766,RO5126766 |
Raf; MEK | MAPK |
Ro 5126766 (CH5126766) 是双重MEK/RAF 抑制剂,抑制BRAFV600E、CRAF、MEK 和 BRAF,IC50分别为 8.2、56、160 和 190 nM。 | |||
T6189 |
Mirdametinib
PD325901,PD0325901 |
Apoptosis; MEK; Autophagy | Apoptosis; Autophagy; MAPK |
Mirdametinib (PD325901) 是一种 MEK 抑制剂 (IC50=0.33 nM),具有选择性、非 ATP 竞争性和口服活性。Mirdametinib 具有抗肿瘤活性,可以抑制 p-ERK1/2 的表达并诱导细胞凋亡。 | |||
T21980 |
PD 198306
|
MEK | MAPK |
PD 198306 是一种具有抗痛觉过敏作用的 MAPK/ERK 激酶 (MEK) 选择性抑制剂。 PD 198306 可降低链脲佐菌素诱导的活性 ERK1 水平升高。 | |||
T6218 |
Selumetinib
ARRY-142886,司美替尼,AZD6244 |
Apoptosis; ERK; MEK | Apoptosis; MAPK |
Selumetinib (AZD6244) 是一种高效选择性的,非 ATP 竞争性的MEK1/2抑制剂, 抑制 MEK1 的IC50为14 nM。它抑制 MEK1/2 磷酸化水平。 | |||
T1144L |
Lidocaine Hydrochloride hydrate
|
EGFR; Sodium Channel | Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors |
Lidocaine Hydrochloride hydrate 是一种酰胺类局部麻醉剂,具有抗炎作用。 | |||
T5412 |
RO4987655
CH4987655,RG7167 |
MEK | MAPK |
RO4987655 (RG7167) 是一种具有口服活性和高选择性的 MEK 抑制剂,抑制MEK1/MEK2,IC50为 5.2 nM。 | |||
T6083 |
AZD8330
ARRY-424704,ARRY-704 |
ERK; MEK | MAPK |
AZD8330 (ARRY-704) 是非竞争性的 MEK1/MEK2抑制剂,IC50为 7 nM。 | |||
T6760 |
APS-2-79 hydrochloride
APS-2-79 HCl,APS-2-79 |
MEK; MAPK | MAPK |
APS-2-79 hydrochloride (APS-2-79 HCl) 是一种 KSR 依赖性的MEK 拮抗剂,可与 ATPbiotin 竞争性地结合到 KSR2-MEK1 复合物内的KSR2。它与 KSR 结合可将 KSR 处于非活性状态,使其无法再结合 RAF 和激活 MEK,从而阻断 Ras-MAPK 信号通路。 | |||
T0468 |
Lidocaine
Lignocaine,Alphacaine,Xylocaine,利多卡因 |
Apoptosis; ERK; NF-κB; MEK; Sodium Channel; Histamine Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Neuroscience; NF-κB |
Lidocaine (Alphacaine) 是一种酰胺衍生物,抑制涉及复杂电压和依赖性的钠通道,可用于研究室性心律失常。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长,迁移和侵袭。 | |||
T2125 |
Trametinib
GSK1120212,曲美替尼,JTP-74057 |
Apoptosis; MEK; Autophagy | Apoptosis; Autophagy; MAPK |
Trametinib (GSK1120212) 是一种 MEK 抑制剂,抑制 MEK1 和 MEK2 (IC50=0.7/0.9 nM),具有 ATP 非竞争性和口服活性。Trametinib 可以激活自噬,诱导凋亡。 | |||
T6223 |
U0126-EtOH
U0126 Ethanol,U0126 |
Mitophagy; Influenza Virus; MEK; Autophagy | Autophagy; MAPK; Microbiology/Virology |
U0126-EtOH (U0126 Ethanol) 是一种非 ATP 竞争性的选择性MEK1和MEK2抑制剂,IC50分别为 72 nM 和 58 nM。U0126-EtOH 可抑制自噬和线粒体自噬。 | |||
T2378 |
RGB-286638 free base
|
GSK-3; MEK; JAK; CDK | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells |
RGB-286638 free base 是一种新型 CDK 抑制剂,抑制cyclin T1-CDK9、cyclin B1-CDK1、cyclin E-CDK2、cyclin D1-CDK4、cyclin E-CDK3和p35-CDK5活性,IC50分别为 1、2、3、4、5 和 5 nM。它也抑制 GSK-3β、TAK1、Jak2 和 MEK1,IC50值分别为 3、5、50和 54 nM。 | |||
T3623 |
Cobimetinib
可美替尼,考比替尼,RG7420,XL518,GDC-0973 |
Apoptosis; MEK | Apoptosis; MAPK |
Cobimetinib (GDC-0973) 是一种可口服的 MEK1选择性抑制剂,抑制MEK1的IC50为4.2 nM。 | |||
T1144 |
Lidocaine hydrochloride
Lidocaine HCL,盐酸利多卡因,Lignocaine hydrochloride,Xyloneural,Lidothesin |
Apoptosis; ERK; NF-κB; MEK; Sodium Channel | Apoptosis; MAPK; Membrane transporter/Ion channel; NF-κB |
Lidocaine hydrochloride (Lignocaine hydrochloride) 抑制涉及复杂电压和依赖性的钠通道。它通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长,迁移和侵袭。Lidocaine 是一种酰胺衍生物,是一种研究室性心律失常的药物和有效的肿瘤抑制剂。 | |||
T6131 |
Pimasertib
AS703026,MSC1936369B,N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺,SAR 245509 |
MEK | MAPK |
Pimasertib (AS703026) 是一种高效选择性和ATP 非竞争性的MEK1/2抑制剂,可用于癌症研究。 | |||
T80543 |
STE-MEK1(13)
ERK Activation Inhibitor Peptide,Ste-MPKKKPTPIQLNP-NH₂ |
ERK | MAPK |
STE-MEK1(13)(Ste-MPKKKPTPIQLNP-NH2)为一细胞渗透性ERK1/2抑制剂,IC50值为13-30μM,可抑制ERK1/2磷酸化。 | |||
T76556 |
MEK1 Derived Peptide Inhibitor 1
|
||
MEK1Derived Peptide Inhibitor 1,一种肽抑制剂,以IC50值30 μM抑制MEK1激活ERK2。适用于细胞渗透性研究。 | |||
T6636 |
Refametinib
BAY 86-97661,瑞法替尼//瑞美替尼,BAY 869766,RDEA119 |
MEK | MAPK |
Refametinib (RDEA119) 是可口服的、非 ATP 竞争和选择性的 MEK1/MEK2变构抑制剂,IC50分别为 19 和 47 nM。 | |||
T76557 |
Myristoyl-MEK1 Derived Peptide Inhibitor 1
|
||
Myristoyl-MEK1 Derived Peptide Inhibitor 1 是MEK1Derived Peptide Inhibitor 1 的豆蔻酰化形式。Myristoyl-MEK1 Derived Peptide Inhibitor 1 抑制ERK 的激活,IC50为 10 μM。 | |||
T63547 | MEK1/2-IN-2 | ||
MEK1/2-IN-2 是有效的、ATP 竞争性的 MEK1/2 抑制剂,对野生型 MEK1/2 和一组 MEK1/2 突变细胞表现出同等的抑制效果。 | |||
T62079 |
MEK4 inhibitor-2
|
||
MEK4 inhibitor-2 是一种新型的抗胰腺癌的MEK4抑制剂,其IC50值为 83 nM。 | |||
T20168 |
Aurothiomalate sodium
金硫丁二钠,Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate |
Others; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Others |
Aurothiomalate sodium (Miochrysin) 是一种选择性的致癌 PKCι信号传导抑制剂,可抑制肿瘤细胞增殖。它是一种硫氧还蛋白还原酶 (TrxR) 抑制剂,也是一种抗风湿剂。 | |||
T5857 |
Trametinib (DMSO solvate)
Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate) |
Apoptosis; MEK | Apoptosis; MAPK |
Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) 是一种口服有效的 MEK 抑制剂,抑制 MEK1 和 MEK2 的 IC50分别为 2 nM。它还能激活自噬,诱导凋亡。 | |||
T9321 |
zapnometinib
ATR-002,3,4-difluoro-2-(2-chloro-4-iodophenylaMino)-benzoic acid,PD0184264,2-(2-chloro-4-iodoanilino)-3,4-difluorobenzoic acid |
Influenza Virus; MEK; Antibacterial | MAPK; Microbiology/Virology |
Zapnometinib (ATR-002) 是 CI-1040 的活性代谢物,是一种 MEK 抑制剂,IC50值为 5.7 nM,有抗流感病毒的抗病毒和抗菌活性。 | |||
T79144 |
PROTAC MEK1 Degrader-1
|
PROTACs | PROTAC |
PROTACMEK1Degrader-1是一种针对MEK1的PROTAC,显示出pIC50值为7.0。该化合物由MEK1抑制剂与von Hippel-Lindau配体构成,能够抑制ERK1/2的磷酸化,并对A375细胞展现出抗增殖活性。 | |||
T72407 | c-Met/MEK1/Flt-3-IN-1 | ||
Antiproliferative against-3 具有良好的抗癌细胞增殖活性,对 Hela、A549 和 MCF-7 的细胞的 IC50值分别为 0.21 µM、0.39 µM 和 0.33 µM。Antiproliferative against-3 (comp 33) 剂量依赖性的诱导 A549 细胞的凋亡,并将细胞阻滞在 G1 期。 | |||
T21332 |
U0126
U 0126,U-0126 |
Mitophagy; MEK; Autophagy | Autophagy; MAPK |
U0126 是一种有效的特异性非竞争性 MAP 激酶抑制剂,抑制 MEK-1 和 MEK-2,IC50 值分别为 0.07 和 0.06 μM。 U0126 抑制自噬和线粒体自噬。 | |||
T22677 |
Cobimetinib racemate
Cobimetinib (racemate),考比替尼 (外消旋体) |
MEK | MAPK |
Cobimetinib racemate (Cobimetinib (racemate)) 是 Cobimetinib 的外消旋体,是一种选择性 MEK 抑制剂。 | |||
T76777 |
Bermekimab
MABp1 |
IL Receptor | Immunology/Inflammation |
Bermekimab (MABp1) 是一种人源化抗白介素-1α (IL-1α) 的单克隆抗体。Bermekimab 具有潜在的抗炎活性,可预防皮肤炎症。 | |||
T76798 | Bimekizumab | ||
Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) 是一种人源化单克隆抗体,可选择性中和 IL-17A 和 IL-17F。这两种细胞因子都能够促进成骨的人骨膜衍生细胞 (hPDC) 分化。因此,Bimekizumab 的应用,可以阻断炎症驱动的成骨分化。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMS2181 |
trans-Zeatin
(E)-Zeatin,玉米素 |
ERK; MEK; Endogenous Metabolite | MAPK; Metabolism |
trans-Zeatin ((E)-Zeatin) 是植物细胞分裂素,可抑制紫外线诱导的MEK/ERK 的活化,在细胞生长、分化和分裂中起着重要的作用。 | |||
T7030 |
anemarsaponin B
知母皂苷B,知母皂苷 B |
p38 MAPK; NF-κB; MEK; COX; NO Synthase | Immunology/Inflammation; MAPK; Neuroscience; NF-κB |
Anemarsaponin B 是一种甾体皂苷,可降低iNOS 和COX-2的蛋白和 mRNA 水平,减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-κB 的 p65 亚基的核转位,还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。 | |||
T2836 |
Isorhamnetin
3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin |
MEK; PI3K; Endogenous Metabolite | MAPK; Metabolism; PI3K/Akt/mTOR signaling |
Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮,可通过抑制MEK1和PI3K 来抑制皮肤癌。 | |||
T6S1740 |
Nardosinone
苷松新酮,甘松新酮 |
Others | Others |
Nardosinone 是一个 dbcAMP 和 staurosporine 的神经生成作用增强剂,分离自Nardostachys chinensis 中。Nardosinone 可能成为一种有用的药理学工具,不仅可用于研究神经生长因子 (NGF) 的作用机理,而且可用于研究神经毒性物质的作用机理。 | |||
T7190 |
Actein
|
Apoptosis; Akt; JNK; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Actein 是从升麻的根茎中分离的一种三萜糖苷,通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖,诱导自噬和凋亡。 | |||
T17261 | Xantocillin | Others | Others |
Xanthocillin is a marine agent. Xanthocillin also induces autophagy through inhibition of the MEK/ERK pathway. | |||
TN1953 |
Morusinol
桑根皮醇,桑树醇 |
ERK; MEK; Autophagy; Ras | Autophagy; GPCR/G Protein; MAPK |
Morusinol 是从桑树根皮中提取出的类黄酮。 Morusinol 具有抗血小板和抗癌活性,在体内抑制动脉血栓形成,通过诱导自噬、G2/M 细胞周期阻滞、抑制细胞侵袭和迁移以及靶向 Ras/MEK/ERK 通路发挥抗肿瘤活性。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00023 |
Midkine Protein, Human, Recombinant (His & Avi)
MDK,MEK,MK1,MKARAP,ARAP,MK,NEGF2 |
Human | E. coli |
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Midkine Protein, Hu... | |||
TMPK-00024 |
Midkine Protein, Human, Recombinant (His & Avi), Biotinylated
MK1,MK,MDK,NEGF2,MKARAP,MEK,ARAP |
Human | E. coli |
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Midkine Protein, Hu... | |||
TMPK-00812 |
Midkine Protein, Mouse, Recombinant (His)
MK1,ARAP,MKARAP,MEK,MK,NEGF2,MDK |
Mouse | E. coli |
Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human malignancies and acts as a mediator for the acquisition of critical hallmarks of cancer, including cell growth, survival, metastasis, migration, and angiogenesis. Midkine Protein, Mo... | |||
TMPY-04544 |
MEK2 Protein, Human, Recombinant (GST)
mitogen-activated protein kinase kinase 2,FLJ26075,MKK2,CFC4... |
Human | Baculovirus Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion ... | |||
TMPY-04572 |
MKK4 Protein, Mouse, Recombinant (His & GST)
MKK4,MEK4,PRKMK4,Sek1,JNKK1,Serk1,mitogen-activated... |
Mouse | Baculovirus Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / ... | |||
TMPJ-01378 |
Mp1 Protein, Human, Recombinant (His)
Mitogen-Activated Protein Kinase Kinase 1-Interacting Protei... |
Human | E. coli |
Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the eff... | |||
TMPY-04756 |
MEK1 Protein, Mouse, Recombinant
Prkmk1,MAPKK1,mitogen-activated protein kinase kinase 1,... |
Mouse | Baculovirus Insect Cells |
MEK1 Protein, Mouse, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 43.6 kDa and the accession number is P31938. | |||
TMPY-04569 |
MEK1 Protein, Mouse, Recombinant (His & GST)
MEKK1,mitogen-activated protein kinase kinase 1,Prk... |
Mouse | Baculovirus Insect Cells |
MEK1 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 71.3 kDa and the accession number is P31938. | |||
TMPY-04364 |
MKK6 Protein, Human, Recombinant (His & GST)
MKK6,mitogen-activated protein kinase kinase 6,SAPKK3,MAPKK6... |
Human | Baculovirus Insect Cells |
MKK6 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 65.3 kDa and the accession number is P52564-1. | |||
TMPY-04749 |
MKK6 Protein, Human, Recombinant (S207D, T211D)
MAPKK6,PRKMK6,MKK6,MEK6,mitogen-activated protein k... |
Human | Baculovirus Insect Cells |
MKK6 Protein, Human, Recombinant (S207D, T211D) is expressed in Baculovirus insect cells. The predicted molecular weight is 37.7 kDa and the accession number is P52564-1. | |||
TMPY-04365 |
MKK6 Protein, Human, Recombinant (S207D, T211D, His & GST)
SAPKK3,mitogen-activated protein kinase kinase 6,MKK6,MAPKK6... |
Human | Baculovirus Insect Cells |
MKK6 Protein, Human, Recombinant (S207D, T211D, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 65.3 kDa and the accession number is P52564-1. | |||
TMPY-04748 |
MKK6 Protein, Human, Recombinant
MKK6,MAPKK6,SAPKK-3,SAPKK3,PRKMK6,MEK6,mitogen-acti... |
Human | Baculovirus Insect Cells |
MKK6 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 37.6 kDa and the accession number is A8K3Y2. | |||
TMPY-05004 |
FGF-4 Protein, Human, Recombinant
HST-1,KFGF,fibroblast growth factor 4,HSTF1,K-FGF,HST,HBGF-4 |
Human | E. coli |
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specification of both blood and skeletal muscle lineages. Fibroblast growth factor 4 (FGF4) signaling induces differentiation from embryonic stem cells (ESCs) via the phosphorylation of downstream molecules such as mitogen-activated protein kinase/extracellular signal-related kinase (MEK) a... | |||
TMPH-03368 |
SG3/Secretogranin 3 Protein, Rat, Recombinant (His & Myc)
|
Rat | E. coli |
Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway. SG3/Secretogranin 3 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 58.2 kDa and the accessio... | |||
TMPY-04410 |
MAP4K5 Protein, Human, Recombinant (His & GST)
KHS,GCKR,MAPKKKK5,mitogen-activated protein kinase kinase ki... |
Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase kinase kinase kinase 5, also known as Kinase homologous to SPS1/STE2, MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5, and MAP4K5, is a cytoplasm protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. MAP4K5 is ubiquitously expressed in all tissues examined, with high levels in the ovary, testis, and prostate. It contains one CNH domain and one protein kinase domain. MAP4K5 is highly similar to yeast SPS... | |||
TMPY-04389 |
MAP3K8 Protein, Human, Recombinant (GST)
TPL2,MEKK8,EST,ESTF,COT,Tpl-2,c-COT,AURA2,mitogen-a... |
Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase kinase subfamily. MAP3K8 is expressed in several normal tissues and human tumor-derived cell lines. Isoform 1 of MAP3K8 is activated specifically during the S and G2/M phases of the... | |||
TMPY-04412 |
Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST)
mitogen-activated protein kinase kinase kinase kinase 2,GCK,... |
Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein, and MAP4K2, is cytoplasm and peripheral membrane protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. MAP4K2 contains one CNH domain and one protein kinase domain. Although this kinase is found in many tissues, its express... | |||
TMPY-04374 |
MST4 Protein, Human, Recombinant (GST)
serine/threonine protein kinase 26,MST4,MASK |
Human | Baculovirus Insect Cells |
MST4, also known as mammalian STE2-like protein kinase 4, is a novel member of the germinal center kinase subfamily of human Ste2-like kinases and is closely related to MST3. The 416 amino acid full-length MST4 contains a C-terminal regulatory domain and an N-terminal kinase domain, both of which are required for full activation of the kinase. MST4 is highly expressed in the placenta, thymus, and peripheral blood leukocytes. MST4 specifically activates ERK but not JNK or p38 MAPK in transiently ... | |||
TMPY-02519 |
BLVRB Protein, Human, Recombinant (His)
HEL-S-10,biliverdin reductase B,FLR,BVRB,SDR43U1 |
Human | E. coli |
Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann-fold) and a C-terminal domain that contains a six-stranded β-sheet that is flanked on one face by several α-helices. The C-terminal and N-terminal domains interact extensively, forming the active site cleft at their interface. Biliverdin reductase (BVR) catalyzes the last step i... | |||
TMPY-04562 |
GRK2 Protein, Human, Recombinant (His & GST)
β,adrenergic, beta, receptor kinase 1 |
Human | Baculovirus Insect Cells |
G-protein coupled receptor kinase 2 (GRK2), also referred as Adrenergic, beta, receptor kinase 1 (ADRBK1), is a ubiquitous member of the G protein-coupled receptor kinase (GRK) family that appears to play a central, integrative role in signal transduction cascades. GRK2 can phosphorylate a growing number of non-GPCR substrates and associate with a variety of proteins related to signal transduction, thus suggesting that this kinase could also have diverse 'effector' functions. GRK2 has been repor... |