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Search Results for " mcf-7 cell "

83

抑制剂 & 化合物

68

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9541	CTB Cholera Toxin B subunit	Epigenetic Reader Domain	Chromatin/Epigenetic
	CTB (Cholera Toxin B subunit) 是一种 p300 组蛋白乙酰转移酶的激活剂，可诱导 MCF-7 细胞凋亡。
T15578	Indotecan NSC-724998,LMP-400	Topoisomerase	DNA Damage/DNA Repair
	Indotecan (LMP-400) 是一种有效的拓扑异构酶 1 抑制剂，对 P388、HCT116和MCF-7 细胞系的IC50值分别为 300、1200和560 nM。
T77718	FAK-IN-10	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	FAK-IN-10 是一种 FAK 的抑制剂（IC50:76.3 μM)。FAK-IN-10 z MCF-7 和 A431 细胞系中显示出抗肿瘤活性，IC50 分别为 4.23 和 0.78 μM 。
T36970	STD1T	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	STD1T 是一种具有选择性和有效性的脱泛素酶 USP2a 抑制剂，具有潜在的抗癌活性，可降低 HCT116 结肠和 MCF-7 乳腺癌细胞中的细胞周期蛋白 D1 蛋白水平。
T21804	GW 610	Others	Others
	GW 610 是一种抗肿瘤剂，能够选择性作用于肺癌、结肠癌和乳腺癌细胞系，具有抗癌活性。
T83627	Pim-1 kinase inhibitor 8	Pim; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling
	Pim-1 kinase inhibitor 8 是一种高效的 Pim-1 kinase 抑制剂，具有抗癌活性，可有效抑制细胞迁移。Pim-1 kinase inhibitor 8 对 MCF-7 和 HepG2 细胞有细胞毒性，是研究乳腺癌的候选化合物。
T5350	JG-98 JG98,JG 98	Apoptosis; HSP	Apoptosis; Cytoskeletal Signaling; Metabolism
	JG-98 是一种热休克蛋白 70 (Hsp70)变构抑制剂，可与 Hsp70 上的保守位点紧密结合，打断 Hsp70-Bag3 相互作用。它影响癌细胞和肿瘤相关巨噬细胞，具有抗癌活性。
T7057	Methylstat	Histone Demethylase; Others	Chromatin/Epigenetic; Others
	Methylstat 是一种含有 Jumonji C 结构域的组蛋白去甲基化酶 (JMJD) 抑制剂的甲酯前药，具有良好的细胞渗透性。在体外试验中，methylstat 的游离酸可抑制 JMJD2A、JMJD2C、JMJD2E、PHF8 和 JMJD3，IC50 值分别约为 4.3、3.4、5.9、10 和 43 µM。 Methylstat 抑制 JMJD2C 敏感的食管癌细胞系 KYSE150 的生长，GI50 为 5.1 µM，而 methylstat 的游离酸在高达 100 µM 时不抑制细胞生长。 Methylstat 以浓度依赖性方式在多个位点诱导组蛋白高甲基化（KYSE150 细胞中 H3K4me3 和 H3K9me3 的 EC50 = 10.3 和 8.6 µM，MCF-7 细胞中的 EC50 分别为 6.7 和 6.3 µM）。
T31988	Govaniadine
	Govaniadine is a natural potent inducer of apoptosis in MCF-7 cell lines.
T10695	CB1151	Others	Others
	CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 with anti-tumor effects. It inhibits MCF-7 cell growth (IC50: 0.82 nM).
T79109	Estrogen receptor modulator 8	Estrogen Receptor/ERR	Endocrinology/Hormones
	Estrogen receptor modulator8 (compound 4) 为一口服活性化合物，作用为抑制雌激素受体/ERR α（IC50=0.437 nM，MCF-7 细胞）。此化合物能有效抑制MCF-7细胞的增殖，其IC50值仅为0.1 nM。
T63676	Bcl-2-IN-6
	Bcl-2-IN-6 是 Bcl-2 (b 细胞淋巴瘤-2) 的有效抑制剂，可下调 Bcl-2 的表达，并提高 p53、Bax、caspase-7 mRNA 的表达。Bcl-2-IN-7 能够诱导乳腺癌 MCF-7 细胞周期阻滞和凋亡。Bcl-2-IN-7 能够作用于 MCF-7 细胞 (IC50: 20.91 μM)、LoVo 细胞 (IC50: 22.30 μM)、HepG2 细胞 (IC50: 42.29 μM) 和 A549 细胞 (IC50: 48.00 μM) 均显示出良好的抗肿瘤效果。
T83874	S-72
	S-72是一种微管聚合抑制剂，以1, 3, 10 µM的浓度在无细胞测定中抑制微管聚合，并在MCF-7和耐紫杉醇的MCF-7/T乳腺癌细胞中降低细胞活性（IC50分别为15.64和26.32 nM）。50 nM浓度的S-72能抑制MCF-7和MCF-7/T细胞的迁移和侵袭，并减少划痕实验中的伤口闭合百分比。100 nM的S-72在MCF-7/T细胞中诱导G2/M期的细胞周期阻滞以及凋亡，并在同一浓度下抑制这些细胞中干扰素基因激活剂（STING）的激活。以每天15 mg/kg的剂量，S-72抑制了耐紫杉醇的MCF-7/T和MX-1/T小鼠异种移植模型中的肿瘤生长。
T72479	Anticancer agent 66
	Anticancer agent 66 是一种抗癌剂。Anticancer agent 66 在 MCF-7 细胞中诱导细胞凋亡 (apoptosis) 并增加亚 G1 细胞群。Anticancer agent 66 是一种环丙沙星类似物。
T79728	EGFR/CDK2-IN-3	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR/CDK2-IN-3（compound 4b）是一种针对EGFR与CDK-2的双重抑制剂，分别具有71.7 nM和113.7 nM的IC50s。该化合物在MCF-7细胞中能诱导凋亡，导致细胞周期在S期停滞，并显示出对癌细胞的明显毒性，其对MCF-7细胞的IC50值为3.16 μM。
T63521	Bcl-2-IN-7
	Bcl-2-IN-7 是 Bcl-2(b 细胞淋巴瘤 -2) 的有效抑制剂，能够下调 Bcl-2 的表达，提高 p53、Bax、caspase-7 mRNA 的表达，能够诱导乳腺癌 MCF-7 细胞周期阻滞和凋亡。Bcl-2-IN-7 对 MCF-7 细胞 (IC50: 20.17 μM)、LoVo 细胞 (IC50: 22.64 μM)、HepG2 细胞 (IC50:45.57 μM) 和 A549 细胞 (IC50: 51.50 μM)均表现出良好的抗肿瘤活性。
T63917	Anticancer agent 67
	Anticancer agent 67 是环丙沙星类似物，是一种抗癌剂，在 MCF-7 细胞中能够诱导细胞凋亡 (apoptosis) 并增加亚 G1 细胞群。
T82715	Cisplatin-resistant cells-IN-1
	Cisplatin-resistant cells-IN-1（化合物8）对顽固的铂类药物抗性细胞具有较高的细胞毒性。在低纳摩尔浓度范围内（IC50：0.14–1.79 μM in A549/A549-R, K562/K562-R, and MCF-7/MCF-7TamR cells），该化合物能有效降低代谢活性。
T61823	Anticancer agent 63
	Anticancer agent 63 (compound 3h) exhibits significant cytotoxic activity against multiple cancer cell lines, including SW480, HeLa, A549, and MCF-7, with IC 50 values of 4.9, 11.5, 9.4, and 3.4 μM, respectively, after 24 hours of treatment. In particular, Anticancer agent 63 induces apoptosis in MCF-7 cells by down-regulating Bcl-2 expression and up-regulating IL-2 and Caspase-3 expression. Additionally, Anticancer agent 63 demonstrates antioxidative properties [1].
T36744	CDK9 Antagonist-1 CDK9 Antagonist-1
	CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1]. CDK9\|17 μM (IC50, MCF-7 cells) [1]. Bian J , et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
T63205	HSP90-IN-13
	HSP90-IN-13（compound 5k）是一种有效的HSP90抑制剂，具有25.07 nM的IC50值，并对EGFR、VEGFR-2以及Topoisomerase-2展现出多靶点作用。此外，HSP90-IN-13能够在G2/M期阻滞MCF-7细胞周期，并通过线粒体途径诱导细胞凋亡(apoptosis)。
T78051	Necrocide 1	Others	Others
	Necrocide 1（化合物(S)-38）是一款有效的抗癌药物，具备显著的抗增殖效果，针对MCF-7和PC3细胞株的IC50值分别为0.48 nM及2 nM。
T83018	Antiproliferative agent-39
	Antiproliferative agent-39 (Compound 12)于 A549、SNU-638、Col2、HT1080、MCF-7 细胞系展现抑制增殖作用，其 IC50 值分别为 11、25、14、11, 6.3 μM。
T79729	EGFR/CDK2-IN-4	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR/CDK2-IN-4（化合物4c）是一种EGFR与CDK-2的双重抑制剂，其IC50值分别为89.6 nM和165.4 nM。该化合物在MCF-7细胞中能诱导(apoptosis)凋亡，并导致细胞周期在S期停滞。EGFR/CDK2-IN-4显示出显著的抗癌细胞毒性，对MCF-7细胞的IC50为2.74 μM。
T74340	DNA crosslinker 4 dihydrochloride
	DNA crosslinker 4 (dihydrochloride) 作为高效的DNA小沟结合剂，对NCI-H460、A2780和MCF-7癌细胞表现出显著抑制活性，适用于抗癌研究。
T79727	EGFR/CDK2-IN-2	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR/CDK2-IN-2（compound 6a）是一种针对EGFR和CDK-2的双重抑制剂，具有19.6 nM和87.9 nM的IC50s。该化合物能在MCF-7细胞内诱导凋亡，并在S期引发细胞周期停滞。此外，EGFR/CDK2-IN-2展现出IC50为0.39 μM的显著抗癌活性，对MCF-7细胞具有强效的细胞毒性。
T63455	PI3K/Akt/mTOR-IN-3
	PI3K/Akt/mTOR-IN-3 是 PI3K/Akt/mTOR 的有效抑制剂。PI3K/Akt/mTOR-IN-3 能够抑制 MCF-7 细胞 (IC50: 0.77 μM)、HeLa 细胞 (IC50: 1.23 μM) 和 HepG2 细胞(IC50: 4.57 μM)。PI3K/Akt/mTOR-IN-3 在 4 μM 浓度下可抑制 MCF-7 和 HeLa 细胞的迁移。PI3K/Akt/mTOR-IN-3 能够将细胞周期阻滞在 S 期，并诱导细胞凋亡 (apoptosis)。
T64026	ERα antagonist 1
	ERα antagonist 1 是选择性的、有效的、共价雌激素受体 α (ERα)拮抗剂。ERα antagonist 1 能够将 MCF-7 细胞的细胞周期阻滞在 G0/G1 期，并诱导其凋亡 (apoptosis)。
T79400	VEGFR-2-IN-35	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	VEGFR-2-IN-35（compound 7）作为 VEGFR-2 抑制剂，展示出37 nM 的IC50值；同时，该化合物对MCF-7 和 HCT 116 癌细胞的抑制效果显著，IC50值分别为10.56 μM 和7.07 μM。
T79651	EGFR-IN-83	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-83（化合物9）为EGFR抑制剂，IC50为2.53 nM。该化合物对MCF-7及MDA-MB-231细胞显示出抗增殖作用，其IC50值分别为2.50 μM及1.96 μM。此外，EGFR-IN-83能够诱导细胞凋亡。
T79383	ER degrader 7
	ER degrader 7 (Compound 35t) 是一种既能降解ERα又能降解ERβ的化合物。该化合物具有抑制微管蛋白聚合的功能，并能有效降低多种细胞系（包括MCF-7、T47D、MCF-10A、LCC2、T47D D538G与T47D Y537S）的细胞活性，相应IC50s值分别为0.06、2.56、15.84、1.59、1.67、1.37 μM。此外，ER degrader 7 对乳腺癌肿瘤生长同样有抑制作用。
T61032	Carbonic anhydrase inhibitor 10
	Carbonic anhydrase inhibitor 10 可用于研究癌症，它对 MCF-7 癌细胞表现出抗增殖活性， IC50值为 11.9 μM。Carbonic anhydrase inhibitor 10 是 hCA IX 的有效抑制剂，Ki 值为 6.2 nM。
T37027	MHAPC-Chol
	MHAPC-Chol is a cationic cholesterol. MHAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also been used to deliver siRNA into mice via intravenous injection, resulting in MHAPC-chol accumulation in the liver.
T69888	SB02024
	SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7, in vivo. Vps34 inhibitor significantly potentiated cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro in monolayer cultures and when grown as multicellular spheroids. Our data suggests that inhibition of autophagy significantly improves sensitivity...
T17728	PROTAC CDK9 degrader-2	Others	Others
	PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].
T13685	ERD-308	Others	Others
	ERD-308 induces >95% of ER degradation at concentrations as low as 5 nM in both cell lines (DC50 (concentration causing 50% of protein degradation) of 0.17 nM and 0.43 nM in MCF-7 and T47D ER+ cells, respectively).ERD-308 is a highly potent PROTAC degrade
T83078	Anticancer agent 33
	Anticanceragent 33 (compound 3) 为Squamocin与Bullatacin衍生物，展现出有效的抗癌特性。本化合物对4T1乳腺癌细胞系（包括A549、HeLa、HepG2和MCF-7细胞）的生长抑制作用显著，其IC50范围为1.9-5.4 µM。
T82931	Aurora A inhibitor 3	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Aurora A inhibitor3 (Compound 5h) 是一种抑制Aurora-A激酶活性的化合物，IC50为0.78 μM。该化合物同时对MCF-7和MDA-MB-231细胞线表现出细胞毒性，其GI50值分别为0.12 μM和0.63 μM。
T74338	DNA crosslinker 2 dihydrochloride
	DNA crosslinker 2 (dihydrochloride)为一种高效DNA小沟结合剂，其结合亲和力(ΔTm)达1.2°C。该化合物对NCI-H460、A2780及MCF-7癌细胞展示出抑制活性，适用于抗癌研究。
T72200	Antiproliferative agent-11
	Antiproliferative agent-11 是一种具有抗增殖活性和选择性的 Ruthenium(II)-Tris-pyrazolylmethane 复合物。Antiproliferative agent-11 对 MCF-7，HeLa，518A2，HCT116 和 RD 细胞具有抗增殖活性，其 IC50值分别为 6，10，6.8，6.7 和 6 μM。Antiproliferative agent-11 可用于癌症的研究。
T81249	Ru3	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Ru3是一种poly(ADP-ribose)polymerase 1抑制剂，能够通过诱导DNA损伤、抑制DNA修复机制、扰乱细胞周期、降低线粒体膜电位及增加reactive oxygen species水平来诱导MCF-7细胞的apoptosis。
T61717	Topoisomerase I inhibitor 4
	Topoisomerase I inhibitor 4 (compound 7a) is a potent inhibitor of topoisomerase I activity. It effectively inhibits the proliferation of various cancer cell lines including HepG2, A549, MCF-7, and HeLa, with IC50 values of 1.20 μM, 2.09 μM, 1.56 μM, and 1.92 μM, respectively. Thus, Topoisomerase I inhibitor 4 holds promise for cancer research applications [1].
T36458	CAY10701 CAY10701
	CAY10701 is a 7-deazahypoxanthine analog that prevents microtubule formation, blocking the proliferation of HeLa and MCF-7 cells (GI50s = 22 and 38 nM, respectively). It also inhibits the growth of several different colorectal cancer cell lines (GI50 values range from 9 to 17 nM), while being at least 1,500-fold less effective against normal human fibroblast WI38 cells. CAY10701 is effective in vivo, reducing tumor volume in colorectal cell xenografts in mice without significantly altering body ...
T78980	Pim-1 kinase inhibitor 5	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	Pim-1 kinase inhibitor 5 (Compound 4c)是一种选择性Pim-1激酶抑制剂，具有0.61 μM的半抑制浓度(IC50)。该化合物对HepG2、MCF-7、PC3和HCT-116癌细胞系表现出细胞毒性，其IC50s值介于6.95至20.19 μM之间。
T37035	HAPC-Chol
	HAPC-Chol is a cationic cholesterol. HAPC-Chol, as part of a lipoplex with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells in a luciferase assay without affecting cell viability. It has also been used to deliver siRNA into mice via intravenous injection, resulting in HAPC-chol accumulation in the lungs.
T36449	(S)-α-Methylbenzyl Ricinoleamide
	(S)-α-Methylbenzyl ricinoleamide is a fatty acid amide derived from ricinoleic acid and methyl benzylamine. It demonstrates potent growth inhibition of glioma (U251), breast (MCF-7), ovarian (NCI-ADR/RES and OVCAR-3), kidney (786-0), non-small cell lung (NCI-H460), and prostate (PC-3) cancer cells with a mean GI50 value of 6.9 μM.
T61501	Topoisomerase I inhibitor 5
	Topoisomerase I inhibitor 5 is an efficient inhibitor of topoisomerase I, with an IC50 value. It effectively disrupts DNA and inhibits the activity of topoisomerase I. Moreover, it can induce apoptosis in MCF-7 cells and arrest the cell cycle at the G1 phase. Topoisomerase I inhibitor 5 also exhibits potency in reversing P-gp-mediated resistance to Adriamycin [1].
T75078	Antitumor agent-86	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Antitumor agent-86 (compound 5a) 对MCF-7乳腺癌细胞线具有IC50值2.62 µM的抑制活性。该化合物通过促进细胞凋亡和引发细胞周期阻滞来表现其抗癌效能，并对RAS/PI3K/Akt/JNK信号传导途径具有靶向作用。
T61996	Antiproliferative agent-6
	Antiproliferative agent-6 (compound 8a) 是有效的抗肿瘤化合物。Antiproliferative agent-6 具有抗增殖活性，抑制癌细胞系 HCT116、MCF-7、H460 和非肿瘤非整倍体永生角质细胞 HaCaT 的 GI50分别为 0.5 μM、2 μM、0.7 μM 和 3.5 μM。
T36868	4-oxo Docosahexaenoic Acid
	4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 μM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 μM.

化合物

Cat.No: T9541

Synonym: Cholera Toxin B subunit

Target: Epigenetic Reader Domain

Cat.No: T15578

Synonym: NSC-724998,LMP-400

Target: Topoisomerase

Cat.No: T77718

Target: FAK

Cat.No: T36970

Target: DUB

Cat.No: T21804

Target: Others

Pim-1 kinase inhibitor 8

Cat.No: T83627

Target: Pim, PKC

Cat.No: T5350

Synonym: JG98,JG 98

Target: Apoptosis, HSP

Cat.No: T7057

Target: Histone Demethylase, Others

Cat.No: T31988

Cat.No: T10695

Target: Others

Estrogen receptor modulator 8

Cat.No: T79109

Target: Estrogen Receptor/ERR

Cat.No: T63676

Cat.No: T83874

Anticancer agent 66

Cat.No: T72479

Cat.No: T79728

Target: EGFR

Cat.No: T63521

Anticancer agent 67

Cat.No: T63917

Cisplatin-resistant cells-IN-1

Cat.No: T82715

Anticancer agent 63

Cat.No: T61823

CDK9 Antagonist-1

Cat.No: T36744

Synonym: CDK9 Antagonist-1

Cat.No: T63205

Cat.No: T78051

Target: Others

Antiproliferative agent-39

Cat.No: T83018

Cat.No: T79729

Target: EGFR

DNA crosslinker 4 dihydrochloride

Cat.No: T74340

Cat.No: T79727

Target: EGFR

PI3K/Akt/mTOR-IN-3

Cat.No: T63455

ERα antagonist 1

Cat.No: T64026

Cat.No: T79400

Target: VEGFR

Cat.No: T79651

Target: EGFR

Cat.No: T79383

Carbonic anhydrase inhibitor 10

Cat.No: T61032

Cat.No: T37027

Cat.No: T69888

PROTAC CDK9 degrader-2

Cat.No: T17728

Target: Others

Cat.No: T13685

Target: Others

Anticancer agent 33

Cat.No: T83078

Aurora A inhibitor 3

Cat.No: T82931

Target: Aurora Kinase

DNA crosslinker 2 dihydrochloride

Cat.No: T74338

Antiproliferative agent-11

Cat.No: T72200

Cat.No: T81249

Target: PARP

Topoisomerase I inhibitor 4

Cat.No: T61717

Cat.No: T36458

Synonym: CAY10701

Pim-1 kinase inhibitor 5

Cat.No: T78980

Target: Pim

Cat.No: T37035

(S)-α-Methylbenzyl Ricinoleamide

Cat.No: T36449

Topoisomerase I inhibitor 5

Cat.No: T61501

Antitumor agent-86

Cat.No: T75078

Target: Akt

Antiproliferative agent-6

Cat.No: T61996

4-oxo Docosahexaenoic Acid

Cat.No: T36868

Cat. No.	Product Name	Target	Signaling Pathways
TN2105	Proscillaridin A	Topoisomerase	DNA Damage/DNA Repair
	Proscillaridin A 是从Drimia robusta 中提取的一种天然产物。是强力的拓扑异构酶 I 和 II 的抑制剂，IC50值分别为 30 nM 和 100 nM。
TQ0134	Podocarpusflavone A	Topoisomerase	DNA Damage/DNA Repair
	Podocarpusflavone A is a DNA topoisomerase I inhibitor. It has moderated anti-proliferative activity induce cell apoptosis in MCF-7.
TN3049	4-Methoxycinnamyl alcohol	Others	Others
	4-Methoxycinnamyl alcohol 对MCF-7、HeLa 和DU145癌症细胞系显示出毒性，IC50值分别为14.24、7.82和22.10μg/mL。4-methoxycinnamyl alcohol 是从Foeniculum vulgare 中分离出来的。4-Methoxycinnamyl alcohol 没有显示出凋亡作用，却在10μg/mL DNA 碎片研究显示48小时后发生了坏死。
TMS0879	Asiaticoside B 积雪草苷 B,积雪草苷B	Others	Others
	Asiaticoside B 是一种从类叶升麻中分离得到的三萜糖苷，具有抗肿瘤作用。它对 HepG2 和 MCF-7 癌细胞系具有显著的细胞毒性。
T1166	Ellipticine 玫瑰树碱,NSC 71795,Elliptisine	Topoisomerase	DNA Damage/DNA Repair
	Ellipticine (Elliptisine) 是一种有效的抗肿瘤剂，抑制 DNA 拓扑异构酶 II 活性，对白血病、神经母细胞瘤和胶质母细胞瘤有部分活性。
T8724	6-Methoxydihydrosanguinarine	Others	Others
	6-Methoxydihydrosanguinarine 是一种从M. cordata 果实中分离出的生物碱，它对 MCF-7 细胞系(IC50:0.61 μM)和 SF-268 细胞系(IC50:0.54 μM)具有强的细胞毒性。
T4519	Alisol A Alisol-A,泽泻醇 A	Autophagy	Autophagy
	Alisol A (Alisol-A) 是泽泻中的一种三萜类天然产物，可能是一种自噬诱导剂，具有抗癌活性。
T2S0265	Robinin NSC 9222,刺槐素	TLR	Immunology/Inflammation
	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of the human colon cancer cell line Colo 320 expreβing MDR1/LRP was explored by monitoring their uptake of Rhodamine 123, but was shown to have minimal effect. Robinin (NSC-9222) was detected in lysates of the human breast cancer cell line MCF-7 using liquid chromatography-tandem maβ spectrometry.
T5724	Neogambogic acid neo-gambogic acid,新藤黄酸	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Neogambogic acid 是藤黄的有效成分，可诱导细胞凋亡并具有抗癌作用。它有效抑制耐甲氧西林的金黄色葡萄球菌。
TN1727	Helichrysetin 4,2',4'-三羟基-6'-甲氧基查耳酮,蜡菊亭	Apoptosis; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Helichrysetin 是从豆蔻果实中分离出的一种天然产物，是一种 DNA 结合抑制剂，可抑制原位导管癌DCIS 的形成。它抑制细胞生长，可诱导 A549 细胞凋亡。
T5S1607	Morusin Mulberrochromene,桑辛素	NF-κB; Antibacterial; STAT	JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells
	Morusin (Mulberrochromene) 是从M. australis 分离的去乙烯基化黄酮，可抑制NF-κB 和STAT3的活性，具有抗菌、抗肿瘤、抗氧化等各种生物活性。
T5S0506	Rotundic acid Rutundic acid,铁冬青酸	Apoptosis; Others; p38 MAPK; Akt; mTOR	Apoptosis; Cytoskeletal Signaling; MAPK; Others; PI3K/Akt/mTOR signaling
	Rotundic acid (Rutundic acid) 是一种从圆形肠球菌中获得的三萜类天然产物，具有抗炎和保护心脏的能力。它可通过 AKT/mTOR 和 MAPK 途径在肝细胞癌中诱导 DNA 损伤和细胞凋亡。
TN2755	2-Desoxy-4-epi-pulchellin	Anti-infection	Microbiology/Virology
	2-Desoxy-4-epi-pulchellin 是分离自 Polygonum hydropiper 的二氯甲烷可溶部分的一种化合物。
TN3972	Epimedokoreanin B	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Epimedokoreanin B （EKB）是一种从韩国淫羊藿中分离出的异戊烯化类黄酮，在人非小细胞肺癌（NSCLC）A549和NCI-H292细胞中展现出抗癌活性。Epimedokoreanin B 还具有抗炎和抗菌活性，可有清除 DPPH 自由基的活性，能以剂量依赖的方式抑制 MCF-7 和 HepG2 的增殖。Epimedokoreanin B 能显著抑制 N (δ) -（羧甲基）赖氨酸（CML）和 N (Ï) -（羧甲基）精氨酸（CMA）的形成，可通过抑制高级糖化终产物（AGEs）预防糖尿病的临床并发症。
T5S2358	Dehydrocorydaline Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine	BCL; PARP; p38 MAPK; Caspase; Parasite; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Proteases/Proteasome
	Dehydrocorydaline (13-Methylpalmatine) 是一种生物碱。它调节Bax，Bcl-2蛋白表达，激活caspase-7，caspase-8，并使PARP 失活。它能增强p38 MAPK 活化，具有抗炎、抗癌等功效。它具有强大的抗疟疾作用，并具低细胞毒性。
T6S1315	Oroxylin A 千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether	Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy	Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮，具有较强的抗癌作用。
T3729	Ethyl gallate Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯	MMP; NF-κB; Akt; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。
T17155	Trabectedin Ecteinascidin 743,曲贝替定,ET-743	Apoptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	Trabectedin (Ecteinascidin 743) 是一种四氢异喹啉生物碱，有抗肿瘤的活性，通过与 DNA 的小沟结合，阻断应激诱导的蛋白质的转录，诱导 DNA 骨架裂解和癌细胞凋亡，并增加 MCF-7 和 MDA-MB-453 细胞中 ROS 的生成。Trabectedin 在软组织肉瘤和卵巢癌中具有的研究价值。
TN4307	Isolimonexic acid	BCL; Caspase; COX; p53	Apoptosis; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
	Isolimonexic acid exhibits cytotoxicity on MCF-7 cell lines, it also inhibits Panc-28 cancer cell growth.
TN5287	3β,5α-Dihydroxyergosta-7,22-dien-6-one
	3β,5α-Dihydroxy-(22E,24R)-ergosta-7,22-dien-6-one exhibits strong or moderate cytotoxic activities against MCF-7, A549, Hela and KB cell lines with IC50 values 4.98 (MCF-7), 1.95 (A549), 0.68(Hela), and 1.50 uM (KB), respectively.
T13551	Araliadiol	Others	Others
	Araliadiol is a polyacetylenic compound isolated from the leaves of Aralia cordata Thunb. Araliadiol inhibits MCF-7 cell growth (IC50: 6.41 µg/mL).
T40940	7,3′,5′-Trihydroxyflavanone
	7,3′,5′-Trihydroxyflavanone, a flavanoid derivative, promotes apoptotic cell death in MCF-7 cells by augmenting Bax expression. Additionally, this compound demonstrates antioxidant properties.
TN5676	Musellarin B
	Musellarin B is cytotoxic toward several of the human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480).
TN4629	Nemoralisin C	Others	Others
	Nemoralisin C shows antiproliferative activity against HepG2, AGS, MCF-7, and A-549 cancer cell lines.
T83301	5,7-Dimethoxy-2,3-phenanthrenediol
	5,7-Dimethoxy-2,3-phenanthrenediol 表现出雌激素活性，能够促进MCF-7细胞的增殖，并增强ERβ在MCF-7细胞系中的表达。
TN3250	7-Prenyljacareubin	Others	Others
	7-Prenyljacareubin shows moderate cytotoxic activity against HL-60, SMMC-7721, A549, MCF-7, and SW480 cell lines.
TN4630	Nemoralisin	Others	Others
	Nemoralisin exhibits weak cytotoxicities (IC50>10 uM) against HepG2, AGS, MCF-7, and A-549 cancer cell lines.
TN1942	Momordicoside F1 苦瓜皂苷 F1	Others	Others
	Momordicoside F1 may have antiproliferative activities against MCF-7, WiDr, HEp-2, and Doay human tumor cell lines.
TN4116	Garjasmin	Others	Others
	Garjasmine exhibits weak cytotoxic activity against KB and MCF-7 cell lines.
TN1523	Conicasterol	Others	Others
	Conicasterol displays marked cytotoxic activity against human breast adenocarcinoma cell line (MCF-7) with the IC50 value of 6.23 ug/mL.
TN1679	Genistein 7,4'-di-O-β-D-glucoside 染料木素-7,4'-二-O-Β-D-葡萄糖苷,Genistein 7,4'-di-O-beta-D-glucopyranoside,鲁冰花	Others; Estrogen/progestogen Receptor	Endocrinology/Hormones; Others
	Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
TN4355	Jolkinol A	Others	Others
	Jolkinol A can inhibit both MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) cell lines, with GI50 values ranging between 40.9 microM and 95.3 microM.
TN2825	25-Anhydrocimigenol 3-O-beta-D-xyloside	Others	Others
	25-Anhydrocimigenol 3-O-beta-D-xyloside has notable cytotoxicity against HepG2 and MCF-7 cancer cell lines.
TN2828	25-O-ethylcimigenol-3-O-beta-D-xylopyranoside	Others	Others
	25-O-ethylcimigenol-3-O-beta-D-xylopyranoside has notable cytotoxicity against HepG2 and MCF-7 cancer cell lines.
TN3371	Albatrelin G	Others	Others
	Albatrelin G shows weak cytotoxic activity to cell lines HL-60, SMMC-7721, A-549, and MCF-7, in vitro.
TN4299	Isoiridogermanal	Others	Others
	Isoiridogermanal shows similar cytotoxicity with IG(50) around 11 microM and 23 microM against MCF-7 and C32 cell lines, respectively.
TN2184	Schisanlactone E 五内脂	Others	Others
	Schisanlactone E may show moderate cytotoxic activity against the human tumor cell lines Bel-7402, BGC-823, MCF-7 and HL-60.
TN1392	Anhydrosecoisolariciresinol	Others	Others
	Anhydrosecoisolariciresinol can significantly decrease the growth of human breast cancer MCF-7 and MDA-MB-231 cell lines at 50 and 100 microM.
TN2752	2-Deacetoxytaxinine J	Others	Others
	2-Deacetoxytaxinine J shows significant in vitro activity against breast cancer cell line at a concentration of 20 microM and 10 microM in MCF-7 and MDA-MB-231 respectively.
T81686	Neotriptonoterpene
	Neotriptonoterpene 是一种从 T. regelii 分离得到的化合物，在 A2780、HepG2 和 MCF-7 细胞上具有较弱的细胞毒活性，其 IC50 值分别为 65.80 µM、35.45 µM 和 64.80 µM。
TN4963	Scillascillin	Others	Others
	Scillascillin has anticancer activity, it is significantly active against human cancer cell lines MCF-7 (breast cancer) and DU-145 (prostate cancer) with inhibitory concentration (IC)50 values 9.59 and 11.32 ug/ml respectively.
TN1139	Dehydrocavidine Dehydrocorydaline,岩黄连碱	BCL; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Dehydrocavidine (Dehydrocorydaline) 具有抗肿瘤活性，它通过诱导调节 Bax/Bcl-2 介导的细胞凋亡、激活半胱天冬酶以及切割 PARP 来抑制 MCF-7 细胞增殖。
T83578	(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol
	(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol 是一种葫芦烷型三萜。该化合物在 MTT 法检测中对癌细胞系 MCF-7、HepG2、Du145、Colon205 以及 HL-60 均未表现出抑制效果。
TN1464	Camellianin A	RAAS	Endocrinology/Hormones
	Camellianin A has anticancer activity, it can inhibit the proliferation of the human hepatocellular liver carcinoma Hep G2 and human breast adenocarcinoma MCF-7 cell lines in a dose-dependent manner and induce the significant increase of the G0/G1 cell po
TN2052	Periplocoside M	Others	Others
	Periplocoside M possesses observably antitumor activity against SMMC-7721( IC 50=12.9 ng/L),Hela( IC 50=8.63 ng/L) and MCF-7( IC 50=18.5 ng/L) cancer cell lines.
T75490	27-O-(tert-Butyldimethylsilyl)withaferin A
	27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a) 为一种天然茄内酯类化合物，具备诱导细胞凋亡 (apoptosis) 的能力。该化合物对人类癌细胞系HeLa、A-549、MCF-7以及正常Vero细胞展现出抗增殖活性。
TN3237	7-Isopentenyloxy-gamma-fagarine	Others	Others
	7-Isopentenyloxy-gamma-fagarine has highly cytotoxicity against the MCF-7and Jurkat cell line. It has been used as a precursor for the chemical asymmetric synthesis of the enantiopure alkaloids: evoxine, anhydroevoxine and evodine.
T81540	Parthenosin Quercetin 3-O-β-D-glucuronide butyl ester
	Parthenosin (Quercetin 3-O-β-D-glucuronide butester) 是从Calligoum foamoides地上部分分离得到的黄酮类化合物，对HepG2和MCF-7细胞系表现出明显的细胞毒性，其IC50值分别为60.46μg/mL和61.4μg/mL。
TN2979	3-Oxotirucalla-7,24-dien-21-oic acid	Others	Others
	3-Oxotirucalla-7,24-dien-21-oic acid 是首次从蓼属植物中分离得到的已知化合物，可从黑参根中分离得到。3-Oxotirucalla-7,24-dien-21-oic acid 对 MCF-7细胞系显示出强大的细胞毒性。
TN6062	1,3,9-Trimethyluric acid
	1,3,9-Trimethyluric acid exhibits in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 uM. 1,3,9-Trimethyluric a
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天然产物

Proscillaridin A

Cat.No: TN2105

Target: Topoisomerase

Podocarpusflavone A

Cat.No: TQ0134

Target: Topoisomerase

4-Methoxycinnamyl alcohol

Cat.No: TN3049

Target: Others

Cat.No: TMS0879

Synonym: 积雪草苷 B,积雪草苷B

Target: Others

Cat.No: T1166

Synonym: 玫瑰树碱,NSC 71795,Elliptisine

Target: Topoisomerase

6-Methoxydihydrosanguinarine

Cat.No: T8724

Target: Others

Cat.No: T4519

Synonym: Alisol-A,泽泻醇 A

Target: Autophagy

Cat.No: T2S0265

Synonym: NSC 9222,刺槐素

Target: TLR

Neogambogic acid

Cat.No: T5724

Synonym: neo-gambogic acid,新藤黄酸

Target: Apoptosis, Others, Antibacterial

Cat.No: TN1727

Synonym: 4,2',4'-三羟基-6'-甲氧基查耳酮,蜡菊亭

Target: Apoptosis, HIV Protease

Cat.No: T5S1607

Synonym: Mulberrochromene,桑辛素

Target: NF-κB, Antibacterial, STAT

Cat.No: T5S0506

Synonym: Rutundic acid,铁冬青酸

Target: Apoptosis, Others, p38 MAPK, Akt, mTOR

2-Desoxy-4-epi-pulchellin

Cat.No: TN2755

Target: Anti-infection

Epimedokoreanin B

Cat.No: TN3972

Target: Apoptosis, Others, Antibacterial

Dehydrocorydaline

Cat.No: T5S2358

Synonym: Dehydrocorydalin,脱氢紫堇碱,13-Methylpalmatine

Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy

Cat.No: T6S1315

Synonym: 千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether

Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy

Cat.No: T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯

Target: MMP, NF-κB, Akt, Antibacterial

Cat.No: T17155

Synonym: Ecteinascidin 743,曲贝替定,ET-743

Target: Apoptosis, Reactive Oxygen Species

Isolimonexic acid

Cat.No: TN4307

Target: BCL, Caspase, COX, p53

3β,5α-Dihydroxyergosta-7,22-dien-6-one

Cat.No: TN5287

Cat.No: T13551

Target: Others

7,3′,5′-Trihydroxyflavanone

Cat.No: T40940

Cat.No: TN5676

Cat.No: TN4629

Target: Others

5,7-Dimethoxy-2,3-phenanthrenediol

Cat.No: T83301

7-Prenyljacareubin

Cat.No: TN3250

Target: Others

Cat.No: TN4630

Target: Others

Momordicoside F1

Cat.No: TN1942

Synonym: 苦瓜皂苷 F1

Target: Others

Cat.No: TN4116

Target: Others

Cat.No: TN1523

Target: Others

Genistein 7,4'-di-O-β-D-glucoside

Cat.No: TN1679

Synonym: 染料木素-7,4'-二-O-Β-D-葡萄糖苷,Genistein 7,4'-di-O-beta-D-glucopyranoside,鲁冰花

Target: Others, Estrogen/progestogen Receptor

Cat.No: TN4355

Target: Others

25-Anhydrocimigenol 3-O-beta-D-xyloside

Cat.No: TN2825

Target: Others

25-O-ethylcimigenol-3-O-beta-D-xylopyranoside

Cat.No: TN2828

Target: Others

Cat.No: TN3371

Target: Others

Isoiridogermanal

Cat.No: TN4299

Target: Others

Schisanlactone E

Cat.No: TN2184

Synonym: 五内脂

Target: Others

Anhydrosecoisolariciresinol

Cat.No: TN1392

Target: Others

2-Deacetoxytaxinine J

Cat.No: TN2752

Target: Others

Neotriptonoterpene

Cat.No: T81686

Cat.No: TN4963

Target: Others

Dehydrocavidine

Cat.No: TN1139

Synonym: Dehydrocorydaline,岩黄连碱

Target: BCL, PARP

(19R,23E)-5b,19-Epoxy19-ethoxycucurbita-6,23-diene-3b,25-diol

Cat.No: T83578

Cat.No: TN1464

Target: RAAS

Periplocoside M

Cat.No: TN2052

Target: Others

27-O-(tert-Butyldimethylsilyl)withaferin A

Cat.No: T75490

7-Isopentenyloxy-gamma-fagarine

Cat.No: TN3237

Target: Others

Cat.No: T81540

Synonym: Quercetin 3-O-β-D-glucuronide butyl ester

3-Oxotirucalla-7,24-dien-21-oic acid

Cat.No: TN2979

Target: Others

1,3,9-Trimethyluric acid

Cat.No: TN6062

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