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160

抑制剂 & 化合物

28

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T22605	Bifemelane hydrochloride	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Bifemelane hydrochloride 是一种选择性的，有效的，和竞争性的单胺氧化酶A (MAO-A)抑制剂，Ki=4.20 μM，它也非竞争性地抑制MAO-B，Ki=46.0 μM。它具有显著的抗抑郁作用，可用于研究与脑血管疾病有关的认知和情绪障碍。
T6073	OG-L002	Histone Demethylase; Monoamine Oxidase; HSV	Chromatin/Epigenetic; Microbiology/Virology; Neuroscience
	OG-L002 是一种高度选择性的 LSD1有效抑制剂，IC50为 0.02 μM。它抑制HSV IE 基因的表达，还是单胺氧化酶抑制剂，对 MAO-A 和 MAO-B 的IC50分别为 1.38 μM 和 0.72 μM。
T0084	Moclobemide 吗氯贝胺,Ro111163	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Moclobemide (Ro111163) 是可逆的、可透过血脑屏障的单胺氧化酶 (MAO-A) 抑制剂，能够抑制 hMAO-A (IC50=6.061 μM)。它上调慢性应激小鼠海马祖细胞的增殖。
T7048	1,4-Naphthoquinone α-Naphthoquinone,Naphthalene-1,4-Dione,P-Naphthoquinone,1,4-萘醌,para-naphthoquinone	Others; MAO; Topoisomerase	DNA Damage/DNA Repair; Metabolism; Neuroscience; Others
	1,4-Naphthoquinone (P-Naphthoquinone) 被用作单胺氧化酶和 DNA 拓扑异构酶活性的潜在抑制剂，还用于抑制乙酰转移酶活性。
T0006	Methylene Blue trihydrate 碱性亚甲蓝三水合物,Methylthionine chloride,Basic blue 9,亚甲蓝三水合物,Methylene Blue	Guanylate cyclase; Microtubule Associated; NO Synthase; Parasite; Monoamine Oxidase	Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Methylene Blue trihydrate (Basic blue 9) 是鸟苷酸环化酶，单胺氧化酶 A 和 NO 合酶抑制剂。它是血管加压药，在医疗中通常用作染料。它具有抗伤害感受，抗疟疾，抗抑郁和抗焦虑作用，可用于高铁血红蛋白血症，神经退行性疾病和异环磷酰胺引起的脑病的研究。
T79487	MAO A/HSP90-IN-2	Monoamine Oxidase	Neuroscience
	MAO A/HSP90-IN-2（compound 4-C）是一种针对HSP90和MAO A的双重抑制剂，显示出分别对这两种酶有0.016 μM和4.58 μM的IC50值。该化合物能够上调HSP70，降低HER2和磷酸化AKT的表达，同时能减少GL26细胞中由IFN-γ诱导的PD-L1表达增加。此外，MAO A/HSP90-IN-2能够抑制对Temozolomide敏感或耐药的胶质母细胞瘤(GBM)、结肠癌、白血病和非小细胞肺癌细胞的生长，并可能有助于阻止肿瘤逃避免疫监控。
T79486	MAO A/HSP90-IN-1	Monoamine Oxidase	Neuroscience
	MAO A/HSP90-IN-1 (4-b) 是一种针对MAO A和HSP90的双重抑制剂，展现在恶性胶质瘤GL26细胞上的IC50为1.77 μM，针对HSP90α的IC50为0.019 μM。该化合物能够通过抑制MAO A活性和HSP90结合，以及降低HER2和phospho-Akt表达，进而抗击恶性胶质瘤（GMB）。同时，MAO A/HSP90-IN-1 (4-b)可减少PD-L1的表达，从而降低T细胞活化的抑制，有望用来抑制肿瘤的免疫逃逸。该化合物适用于脑肿瘤相关疾病研究。
T61958	MAO A/HDAC-IN-1
	MAO A/HDAC-IN-1 是有效的单胺氧化酶 A (MAO A) 和HDAC 双重抑制剂，可用于胶质瘤研究。
T5887	7-Hydroxy-3,4-dihydro-2(1H)-quinolinone 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone,3,4-二氢-7-羟基-2(1H)-喹啉酮	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	7-Hydroxy-3,4-dihydro-2(1H)-quinolinone 是弱MAO-A 抑制剂，IC50=183 μM，对 MAO-B 无作用。
T6962	Rasagiline Mesylate TVP1012,甲磺酸雷沙吉兰,AGN1135,Azilect	Apoptosis; MAO; Autophagy; Monoamine Oxidase	Apoptosis; Autophagy; Metabolism; Neuroscience
	Rasagiline Mesylate (AGN1135) 是一种高效的，不可逆的选择性线粒体单胺氧化酶 (MAO) 抑制剂，抑制大鼠脑 MAO B 和 MAO A 的IC50分别为 4.43 nM 和 412 nM。
T80799	WAY-620147	MAO	Metabolism; Neuroscience
	WAY-620147 为N-(2-morpholinoethyl)nicotinamide的衍生物，能够抑制单胺氧化酶（Monoamine Oxidase）。WAY-620147 对MAO-A及MAO-B的IC50值分别为26 μM和55 μM，可用于研究神经系统疾病。
T60712	MAO-B-IN-17	MAO	Metabolism; Neuroscience
	MAO-B-IN-17 是一种具有选择性和有效性的单胺氧化酶 B (MAO-B) 抑制剂(IC50：5.08 μM)，可用于研究像帕金森类的中枢神经系统疾病。
T18918	Azure B Azure B chloride,天青 B	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Azure B (Azure B chloride) 是一种 Methylene blue 的主要代谢物，是一种阳离子染料，用于 Azure 曙红染色剂以进行血液涂片染色。它是高选择性和可逆的抑制单胺氧化酶(MAO)-A 的抑制剂，对重组人的 MAO-A 和 MAO-B 的IC50分别为 11 和 968 nM。它具有显著的抗抑郁作用。
T38034	MAO-IN-M30 dihydrochloride M 30 dihydrochloride	Monoamine Oxidase	Neuroscience
	MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) 是一种口服活性，可通过血脑屏障的，脑选择性不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。MAO-IN-M30 dihydrochloride 是有效的铁螯合剂、自由基清除剂。MAO-IN-M30 dihydrochloride 对 Dexamethasone 诱导的脑细胞凋亡具有神经保护作用。MAO-IN-M30 dihydrochloride 在 MPTP 和 lactacystin 帕金森病模型中也显示出神经恢复活性。
T15023	CX-157 KP 157	MAO	Metabolism; Neuroscience
	CX-157 (KP 157) 是一种新型单胺氧化酶-A（MAO-A）抑制剂，可用于研究抑郁症类的神经系统疾病和癌症。
T1578	Pargyline hydrochloride 优降宁盐酸盐,Pargylamine hydrochloride	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Pargyline hydrochloride (Pargylamine hydrochloride) 是不可逆的单胺氧化酶抑制剂，可作用于 MAO-A (Ki=13 μM) 和 MAO-B (Ki=0.5 μM) ，具有降压和抗癌作用。
T1119	Rasagiline 雷沙吉兰,AGN1135,TVP1012	BCL; MAO; Monoamine Oxidase	Apoptosis; Metabolism; Neuroscience
	Rasagiline (AGN1135) 是不可逆的、高效的、选择性的线粒体单胺氧化酶 (MAO) 抑制剂，抑制大鼠脑 MAO B 和 MAO A 的 IC50分别为 4.43 nM 和 412 nM。
T15010	CR4056 6-(1H-imidazol-1-yl)-2-phenylquinazoline	MAO; Imidazoline Receptor	Metabolism; Neuroscience
	CR4056 (6-(1H-imidazol-1-yl)-2-phenylquinazoline) 是一种特异性 MAO-A 抑制剂，IC50 为 202.7 nM，是 I2-咪唑啉受体的配体，IC50 为 596 nM。
T26632	AnnH31	MAO; DYRK	Cell Cycle/Checkpoint; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	AnnH31 是一种有效的 Dyrk1A 抑制剂，IC50 值为 81 nM。AnnH31 对 MAO-A 有抑制作用，IC50 为 3.2 μM。AnnH31 可作为探针，用于确认 DYRK1A 参与细胞磷酸化。
T0300	Pargyline Pargylamine,Paragyline,优降宁	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Pargyline (Pargylamine) 是不可逆的单胺氧化酶抑制剂，对MAO-A 和MAO-B 的Ki 分别为 13 μM 和 0.5 μM，具有降压和抗癌作用。
T21652	RN-1 dihydrochloride	Histone Demethylase; MAO	Chromatin/Epigenetic; Metabolism; Neuroscience
	RN-1 dihydrochloride 是血脑屏障通透性的、不可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 选择性抑制剂，IC50为 70 nM，对 LSD1 的选择性高于 MAO-A 和 MAO-B，IC50分别为 0.51 μM 和 2.785 μM。
T23453	Tetrindole mesylate	MAO	Metabolism; Neuroscience
	Tetrindole mesylate 是一种 MAO-A 抑制剂。
T10079	MAO-IN-1	MAO	Metabolism; Neuroscience
	MAO-IN-1是一种高效的单胺氧化酶B (MAO B)抑制剂（IC50：20 nM），可用于研究神经系统相关疾病。
T8589	(±)-Amiflamine 4-(dimethylamino)-alpha,4-(2-氨基丙基)-N,N,3-三甲基苯胺,Amiflamine,2-dimethylphenethylamine	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	(±)-Amiflamine (2-dimethylphenethylamine) 是一种单胺氧化酶(MAO-A)，pIC50=5.57。
T9759	MAO-B-IN-5
	MAO-B-IN-5 是一种有效的、选择性和具有口服活性的MAO-B 抑制剂，IC50值为 0.204 μM。MAO-B-IN-5 在帕金森病 (PD) 中具有研究潜力。
T27606	Indantadol HCl CHF-3381,CMP-3381,GT-3381,V-3381,CNP-3381,Indantadol	MAO; NMDAR	Metabolism; Neuroscience
	Indantadol HCl (CHF-3381) 是一种 NMDA 拮抗剂和非选择性 MAO 抑制剂。
T68069	Femoxetine	MAO; 5-HT Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Femoxetine 是一种5-HT 抑制剂，具有抗抑郁活性，可增强吗啡诱导的抗伤害感受，抑制小鼠产生高运动能力所需的MAO-A 和MAO-B。
T77564	Coumarin102 Exciton 480
	Coumarin102 (Exciton 480)是一种荧光染料。Coumarin102对Monoamine oxidase B、MAO-B和MAO-A具有较弱的抑制活性，可用来研究神经系统疾病。
T9560	MAO-B-IN-2
	MAO-B-IN-2 是一种选择性和竞争性的MAO-B 和 BChE 抑制剂，其IC50值分别为 0.51 和 7.00 μM。MAO-B-IN-2 通过良好的 ROS 清除特性减轻 H2O2 诱导的细胞损伤。
T2315	GSK-LSD1 dihydrochloride GSK-LSD1 (hydrochloride),GSK-LSD1 2HCl	Histone Demethylase	Chromatin/Epigenetic
	GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) 是一种特异性不可逆的 LSD1 抑制剂(IC50: 16 nM)。GSK-LSD1 dihydrochloride 对 LSD1 的选择性是其他密切相关的 FAD 利用酶（即 MAO-A、LSD2、MAO-B）的 1000 倍以上。
T60932	MAO-B-IN-8	MAO	Metabolism; Neuroscience
	MAO-B-IN-8 is a highly potent and reversible inhibitor of monoamine oxidase-B (MAO-B), which also exhibits inhibitory effects on the microglial production of neuroinflammatory mediators. This compound is specifically designed for use in research related to neurodegenerative diseases [1].
T60671	MAO-B-IN-9	Beta Amyloid; Serotonin Transporter; Monoamine Oxidase	Neuroscience
	MAO-B-IN-9是一种可穿过血脑屏障的单胺氧化酶B MAO-B 抑制剂（IC50：0.18μM），具有有效性、选择性和时间依赖性。MAO-B-IN-9具有神经保护作用，可以防止Aβ1-42诱导的神经元细胞死亡，这可能与Aβ1-42的抗聚集作用有关。
T71934	Atibeprone	MAO	Metabolism; Neuroscience
	Atibeprone 是 MAO-B 抑制剂，具有抗抑郁活性，可用于研究帕金森病。
T0235	Modaline sulfate	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Modaline sulfate 是一种 MAO 抑制剂，用于研究抑郁症。
T28750	Sembragiline RG-1577,EVT-302,RO-4602522,RO4602522,RG1577,EVT302	MAO	Metabolism; Neuroscience
	Sembragiline (EVT-302) 是一种具有选择性的 MAO-B 抑制剂，可用于研究阿尔茨海默病（AD）。
T10089	2614W94	MAO	Metabolism; Neuroscience
	2614W94 是一种选择性 MAO-A 抑制剂，IC50 为 5 nM，Ki 为 1.6 nM。
T6651	Safinamide mesylate PNU-151774E,FCE28073,PNU-151774E,NW-1015,EMD 1195686 mesylate,沙芬酰胺甲磺酸盐	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Safinamide mesylate (EMD 1195686 mesylate) 是选择性的、有效的、可逆的单胺氧化酶 B 的抑制剂，对 MAO-A 选择性较低。它能够阻断钠通道和调节谷氨酸释放。它具有神经保护作用，可用于研究帕金森病、缺血脑卒中等疾病。
T60891	AChE/BChE/MAO-B-IN-1	MAO; AChE	Metabolism; Neuroscience
	AChE/BChE/MAO-B-IN-1是一种可逆的、非时间依赖且可透过血脑屏障的AChE、BChE 和MAO-B 抑制剂，对 hAChE、hBChE 和 hMAO-B 表现出抑制作用，IC50分别为 7.31、0.56 和 26.1 μM。AChE/BChE/MAO-B-IN-1具有神经保护作用且无明显细胞毒性。
T27288	Esuprone LU-43839,LU 43839,LU43839	MAO	Metabolism; Neuroscience
	Esuprone (LU-43839) 是一种新型可逆且具有高选择性的MAO-A 抑制剂，具有抗惊厥活性，可用于治疗抑郁症。
T5676	(Z)-SU4312	MAO; NOS	Immunology/Inflammation; Metabolism; Neuroscience
	(Z)-SU4312 是 MAO-B 和 NOS 的抑制剂（IC50 值分别为 0.2 μM 和 19.0μM）。
T16803	RS 8359	MAO	Metabolism; Neuroscience
	RS 8359 是单胺氧化酶 A (MAO-A) 的可逆抑制剂，对 A:B 酶类型的特异性比约为 2200。 RS 8359 具有抗抑郁活性。
T24680	PSB-1491	MAO	Metabolism; Neuroscience
	PSB-1491 是一种选择性和竞争性的单胺氧化酶 B 抑制剂，IC50 为 0.386 nM，是 MAO-A 的 25000 倍以上。
T8907	Minaprine dihydrochloride 米那卜林二盐酸盐	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Minaprine dihydrochloride 是一种可逆的单胺氧化酶 MAO-A 抑制剂，对乙酰胆碱酯酶有微弱抑制，是一种抗抑郁类化合物。
T17211	Vafidemstat ORY-2001	Histone Demethylase; MAO	Chromatin/Epigenetic; Metabolism; Neuroscience
	Vafidemstat (ORY-2001) 是一种可透过血脑屏障且具有选择性、口服活性的赖氨酸-组蛋白去甲基化酶 (LSD1)/MAO-B 抑制剂，可用于研究神经系统疾病。
T5053	Eprobemide LIS 630,依普贝胺	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Eprobemide (LIS 630) 是一种非竞争性的、可逆的单胺氧化酶 A 抑制剂。
T7942	Tranylcypromine hemisulfate Tranylcypromine Sulfate,Tranylcypromine (hemisulfate),反苯环丙胺半硫酸盐	Histone Demethylase; MAO; Monoamine Oxidase	Chromatin/Epigenetic; Metabolism; Neuroscience
	Tranylcypromine hemisulfate (Tranylcypromine Sulfate) 是单胺氧化酶(MAO) 和赖氨酸特异性去甲基化酶 1 (LSD1) 的抑制剂，可用于研究抑郁症和子宫内膜异位症。
T6651L	Safinamide EMD1195686,FCE26743,FCE 26743,EMD-1195686,EMD 1195686,FCE-26743	MAO	Metabolism; Neuroscience
	Safinamide (FCE-26743) 是一种可逆选择性单胺氧化酶 B (IC50 0.098μM)抑制剂，可减少多巴胺的降解，也是一种谷氨酸释放抑制剂(IC50 8μM)。它还能抑制多巴胺的再摄取。 Safinamide 还能阻断钠和钙通道。 Safinamide 的潜在的其他用途可能是帕金森病、不宁腿综合征和癫痫。
T24679	PSB-1434 PSB 1434,PSB1434	MAO	Metabolism; Neuroscience
	PSB-1434 是一种选择性和竞争性的单胺氧化酶 B 抑制剂，IC50 为 1.59 nM，相对于 MAO-A 的选择性>6000 倍。
T50055	Milacemide	MAO	Metabolism; Neuroscience
	Milacemide 是一种甘氨酸前药和 MAO-B 抑制剂。已经研究了米拉塞米对人类记忆的影响以及作为阿尔茨海默病症状的潜在治疗方法。
T26930	BW-1370U87 1370U 87,1370U-87,1370U87,BW 1370U87
	BW-1370U87 is a monoamine oxidase A (MAO-A) inhibitor. BW-1370U87 elevates neurotransmitter amines in the brain over the same dose range at which it exhibits positive activities in animal models of depressive illness. BW-1370U87's mechanism of action foll

化合物

Bifemelane hydrochloride

Cat.No: T22605

Target: MAO, Monoamine Oxidase

Cat.No: T6073

Target: Histone Demethylase, Monoamine Oxidase, HSV

Cat.No: T0084

Synonym: 吗氯贝胺,Ro111163

Target: MAO, Monoamine Oxidase

1,4-Naphthoquinone

Cat.No: T7048

Synonym: α-Naphthoquinone,Naphthalene-1,4-Dione,P-Naphthoquinone,1,4-萘醌,para-naphthoquinone

Target: Others, MAO, Topoisomerase

Methylene Blue trihydrate

Cat.No: T0006

Synonym: 碱性亚甲蓝三水合物,Methylthionine chloride,Basic blue 9,亚甲蓝三水合物,Methylene Blue

Target: Guanylate cyclase, Microtubule Associated, NO Synthase, Parasite, Monoamine Oxidase

MAO A/HSP90-IN-2

Cat.No: T79487

Target: Monoamine Oxidase

MAO A/HSP90-IN-1

Cat.No: T79486

Target: Monoamine Oxidase

MAO A/HDAC-IN-1

Cat.No: T61958

7-Hydroxy-3,4-dihydro-2(1H)-quinolinone

Cat.No: T5887

Synonym: 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone,3,4-二氢-7-羟基-2(1H)-喹啉酮

Target: MAO, Monoamine Oxidase

Rasagiline Mesylate

Cat.No: T6962

Synonym: TVP1012,甲磺酸雷沙吉兰,AGN1135,Azilect

Target: Apoptosis, MAO, Autophagy, Monoamine Oxidase

Cat.No: T80799

Target: MAO

Cat.No: T60712

Target: MAO

Cat.No: T18918

Synonym: Azure B chloride,天青 B

Target: MAO, Monoamine Oxidase

MAO-IN-M30 dihydrochloride

Cat.No: T38034

Synonym: M 30 dihydrochloride

Target: Monoamine Oxidase

Cat.No: T15023

Synonym: KP 157

Target: MAO

Pargyline hydrochloride

Cat.No: T1578

Synonym: 优降宁盐酸盐,Pargylamine hydrochloride

Target: MAO, Monoamine Oxidase

Cat.No: T1119

Synonym: 雷沙吉兰,AGN1135,TVP1012

Target: BCL, MAO, Monoamine Oxidase

Cat.No: T15010

Synonym: 6-(1H-imidazol-1-yl)-2-phenylquinazoline

Target: MAO, Imidazoline Receptor

Cat.No: T26632

Target: MAO, DYRK

Cat.No: T0300

Synonym: Pargylamine,Paragyline,优降宁

Target: MAO, Monoamine Oxidase

RN-1 dihydrochloride

Cat.No: T21652

Target: Histone Demethylase, MAO

Tetrindole mesylate

Cat.No: T23453

Target: MAO

Cat.No: T10079

Target: MAO

(±)-Amiflamine

Cat.No: T8589

Synonym: 4-(dimethylamino)-alpha,4-(2-氨基丙基)-N,N,3-三甲基苯胺,Amiflamine,2-dimethylphenethylamine

Target: MAO, Monoamine Oxidase

Cat.No: T9759

Cat.No: T27606

Synonym: CHF-3381,CMP-3381,GT-3381,V-3381,CNP-3381,Indantadol

Target: MAO, NMDAR

Cat.No: T68069

Target: MAO, 5-HT Receptor

Cat.No: T77564

Synonym: Exciton 480

Cat.No: T9560

GSK-LSD1 dihydrochloride

Cat.No: T2315

Synonym: GSK-LSD1 (hydrochloride),GSK-LSD1 2HCl

Target: Histone Demethylase

Cat.No: T60932

Target: MAO

Cat.No: T60671

Target: Beta Amyloid, Serotonin Transporter, Monoamine Oxidase

Cat.No: T71934

Target: MAO

Modaline sulfate

Cat.No: T0235

Target: MAO, Monoamine Oxidase

Cat.No: T28750

Synonym: RG-1577,EVT-302,RO-4602522,RO4602522,RG1577,EVT302

Target: MAO

Cat.No: T10089

Target: MAO

Safinamide mesylate

Cat.No: T6651

Synonym: PNU-151774E,FCE28073,PNU-151774E,NW-1015,EMD 1195686 mesylate,沙芬酰胺甲磺酸盐

Target: MAO, Monoamine Oxidase

AChE/BChE/MAO-B-IN-1

Cat.No: T60891

Target: MAO, AChE

Cat.No: T27288

Synonym: LU-43839,LU 43839,LU43839

Target: MAO

Cat.No: T5676

Target: MAO, NOS

Cat.No: T16803

Target: MAO

Cat.No: T24680

Target: MAO

Minaprine dihydrochloride

Cat.No: T8907

Synonym: 米那卜林二盐酸盐

Target: MAO, Monoamine Oxidase

Cat.No: T17211

Synonym: ORY-2001

Target: Histone Demethylase, MAO

Cat.No: T5053

Synonym: LIS 630,依普贝胺

Target: MAO, Monoamine Oxidase

Tranylcypromine hemisulfate

Cat.No: T7942

Synonym: Tranylcypromine Sulfate,Tranylcypromine (hemisulfate),反苯环丙胺半硫酸盐

Target: Histone Demethylase, MAO, Monoamine Oxidase

Cat.No: T6651L

Synonym: EMD1195686,FCE26743,FCE 26743,EMD-1195686,EMD 1195686,FCE-26743

Target: MAO

Cat.No: T24679

Synonym: PSB 1434,PSB1434

Target: MAO

Cat.No: T50055

Target: MAO

Cat.No: T26930

Synonym: 1370U 87,1370U-87,1370U87,BW 1370U87

Cat. No.	Product Name	Target	Signaling Pathways
T3885	ROSIRIDIN 6'-O-Deacetylrosiridoside C,络塞定,(-)-Rosiridin	Others; Monoamine Oxidase	Neuroscience; Others
	Rosiridin (6'-O-Deacetylrosiridoside C) 能够抑制 MAO A 和 MAO B，有潜在的抑郁症和老年性痴呆作用。它在 10 μM 时对 MAO B 的抑制率为 83.8% (pIC50=5.38)。
TN2004	Obtusin 1,7-二羟基-2,3,8-三甲氧基-6-甲基蒽-9,10-二酮,决明素	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Obtusin 是来自决明子种子，是一种高度选择性和竞争性的人单胺氧化酶-A 抑制剂，IC50=11.12 μM，Ki=6.15 μM。它在神经退行性疾病，尤其是焦虑和抑郁中起预防作用。
T2900	Paeonol 丹皮酚,Peonol	MAO; Autophagy; Monoamine Oxidase	Autophagy; Metabolism; Neuroscience
	Paeonol (Peonol) 是一种从牡丹中提取的活性物质，可抑制 MAO-A 和 MAO-B，IC50 分别为 54.6 μM 和 42.5 μM。
TN7057	rosmarinate acid (R)-rosmarinic acid,rosmarinic acid,迷迭香素,Rosemary acid	MAO; Endogenous Metabolite; Transferase	Metabolism; Neuroscience
	Rosmarinate acid(Rosemary acid) 抑制 MAO-A、MAO-B 和 COMT 酶，IC50 分别为 50.1、184.6 和 26.7 μM。
T5648	Purpurin 吡啉,1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin	MAO; Antibacterial; Antibiotic; Antifungal	Metabolism; Microbiology/Virology; Neuroscience
	Purpurin (Verantin) 是来自Rubia tinctorumL. 的天然蒽醌，具有抗抑郁样作用。
T3933	Jatrorrhizine Yatrorizine,neprotin,药根碱	MAO; 5-HT Receptor; Antibacterial; AChE	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Jatrorrhizine (neprotin) 是一种从黄连中分离得到的生物碱，具有抗菌、抗氧化、抗疟原虫和神经保护活性。它通过抑制 uptake-2 transporter 的活性减少血清素和去甲肾上腺素的摄取。它是一种有口服活性的乙酰胆碱酯酶制剂。
T4024	Norharmane 2-Azacarbazole,2,9-Diazafluorene,β-Carboline,去甲哈尔满	DNA; Endogenous Metabolite; Monoamine Oxidase	DNA Damage/DNA Repair; Metabolism; Neuroscience
	Norharmane (β-Carboline) 是一种有效的选择性单胺氧化酶 A (MAO-A) 抑制剂，Ki=3.34 μM。
T2765	Rosmarinic acid Labiatenic acid,迷迭香酸,Rosemary acid	Apoptosis; IκB/IKK; MAO; Endogenous Metabolite; Transferase; Monoamine Oxidase	Apoptosis; Metabolism; Neuroscience; NF-κB
	Rosmarinic acid (Labiatenic acid) 广泛存在植物中，具有抗氧化、抗炎和抗菌活性。它抑制 MAO-A，MAO-B 和 COMT，IC50分别为 50.1，184.6 和 26.7 μM。
T10146	4-Hydroxyderricin	Dehydrogenase; MAO	Metabolism; Neuroscience
	4-Hydroxyderricin 是一种有效且具有选择性 MAO-B 抑制剂（IC50：3.43 μM），是当归的主要活性成分，能轻度抑制多巴胺β-羟化酶（DBH）活性，并具有抗抑郁活性。
TN1470	Cassiaside B2 决明子苷B2	Phosphatase; MAO; 5-HT Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Cassiaside B2 是蛋白酪氨酸磷酸酶1B (PTP1B) 和人单胺氧化酶A (hMAO-A) 的抑制剂。Cassiaside B2是 5-HT2C 受体的激动剂，具有抗过敏活性。Cassiaside B2 是萘吡喃酮参比提取物（NRE）的有效成分之一。
T3158	Harmane Loturine,Harman,Aribine,哈尔满碱	Adrenergic Receptor; Monoamine Oxidase; Imidazoline Receptor	GPCR/G Protein; Neuroscience
	Harmane (Loturine) 是一种在咖啡和烟草烟雾中发现的 β-咔啉生物碱，是有效的神经毒素，可引起严重的动作震颤和精神病学表现。它还是选择性的单胺氧化酶抑制剂，具有致突变作用，对 MAO A/B 的 IC50值分别为 0.5 和 5 μM。
T6862	Isatin Pseudoisatin,板蓝根,Indoline-2,3-dione,2,3-Indolinedione	Apoptosis; MAO; Monoamine Oxidase	Apoptosis; Metabolism; Neuroscience
	Isatin (2,3-Indolinedione) 是一种单胺氧化酶抑制剂，IC50为3 μM。它也可作为心钠肽刺激和一氧化氮刺激的鸟苷酸环化酶活性的拮抗剂，显示对血清素系统有影响。
TN1120	Osthenol	MAO; Monoamine Oxidase	Metabolism; Neuroscience
	Osthenol 是一种前酰化香豆素，从独活干根中分离得到。它对重组 hMAO-A 具有潜在的选择性抑制作用，IC50=0.74 µM，对 hMAO-A 和 hMAO-B 表现出较高的选择性指数。它是一种可逆的，选择性的竞争性人单胺氧化酶-A(hMAO-A)抑制剂 (Ki=0.26 µM)。
T1311	4-aminobenzoic acid PABA,Vitamin H1,Vitamin Bx,para-Aminobenzoic acid,对氨基苯甲酸	Endogenous Metabolite	Metabolism
	4-aminobenzoic acid (para-Aminobenzoic acid) 是一种具有紫外线吸收和抗纤维化特性的有机酸。当暴露在光线下时，4-aminobenzoic acid 吸收紫外线并通过光化学反应释放多余的能量，这可能会对DNA造成损害。4-aminobenzoic acid 还可以增加组织水平的摄氧量，并可能增强单胺氧化酶(MAO)活性以促进血清素的降解，过量可能导致纤维化变化。
T1711	Harmine Telepathine,去氢骆驼蓬碱	MAO; 5-HT Receptor; DYRK	Cell Cycle/Checkpoint; GPCR/G Protein; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	Harmine (Telepathine) 是一种从山茱萸种子中分离出来的生物碱，具有抗癌和抗炎活性。它是双特异性酪氨酸磷酸化调节激酶抑制剂，对5-HT2A 血清素受体具有高亲和力，Ki 值为 397 nM。
T3822	Bellidifolin Bellidifoline,龙胆山酮酚,Bellidifolium,雏菊叶龙胆酮	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Bellidifolin (Bellidifoline) 是从獐牙菜的茎中提取的一种呫吨酮，它能作为病毒蛋白 R 的抑制剂，具有保肝、降血糖、抗炎、抗氧化、抗肿瘤作用。
T5S0734	Desmethoxyyangonin Desmethoxy yangonin,去甲氧基醉椒素,Demethoxyyangonin,5,6-Dehydrokavain	Others; Monoamine Oxidase	Neuroscience; Others
	Desmethoxyyangonin (5,6-Dehydrokavain) 是一种MAO-B 可逆性抑制剂。
TN1724	Harmalol hydrochloride Harmidol hydrochloride	P450; Antioxidant	Metabolism; oxidation-reduction
	Harmalol hydrochloride (Harmidol hydrochloride) 是一种可从Peganum harmala L.的种子中提取出来的β-咔啉生物碱。Harmalol hydrochloride 是Harmaline 的主要代谢产物，在转录和翻译后水平上显著抑制二恶英介导的 CYP1A1 诱导。Harmalol hydrochloride 在去氧肾上腺素或KCl 预先收缩的分离大鼠胸主动脉制剂中显示出血管松弛活性。 Harmalol hydrochloride 具有抗氧化活性.
TN3294	8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate	NADPH-oxidase; P450; MAO	Immunology/Inflammation; Metabolism; Neuroscience
	8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
T79979	Methyl piperate	Monoamine Oxidase	Neuroscience
	Methylpiperate，一种胡椒碱类生物碱，展现出显著的MAO抑制活性(IC50 3.6 μM)。该化合物对MAO-B的选择性抑制作用(IC50 1.6 μM)优于对MAO-A(IC50 27.1 μM)，因此可用于治疗精神障碍。
TN2553	1-Methyl-2-undecyl-4(1H)-quinolone 1-Methyl-2-undecylquinolin-4(1H)-one	MAO	Metabolism; Neuroscience
	1-Methyl-2-undecyl-4(1H)-quinolone, and dihydroevocarpine should also be served as the chemical markers together with evodiamine for the quality control of Evodia rutaecarpa (Juss.) Benth. 1-Methyl-2-undecyl-4(1H)-quinolone shows a selective inhibition of type B MAO (MAO-B) activity with the IC(50) value of 15.3 microM using a substrate kynuramine, but does not inhibit type A MAO (MAO-A) activity.It can mitigate high phosphate-induced human aortic valve interstitial cells (HAVICs) calcification ...
TN1099	Dihydroevocarpine	MAO; P-gp; Antifection	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Dihydroevocarpine shows potent anti-Helicobacter pylori activity with the minimum inhibitory concentration (MIC) value of 10-20 microg/ml. Dihydroevocarpine is a moderate modulator of p-glycoprotein (p-gp) activity; it shows more potent inhibitory effects against MAO-B compared to MAO-A.
TN3300	8alpha-Tigloyloxyhirsutinolide 13-O-acetate	NADPH-oxidase; P450; MAO	Immunology/Inflammation; Metabolism; Neuroscience
	8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has anti-cancer activity, it is active against both cancer cell lines (IC50 = 3.50 microM for HT29
T40244	Methyl citrate
	Methyl citrate, obtained from Opuntia ficus-indica var. saboten Makino fruits, serves as a potent Monoamine oxidase B (MAO-B) inhibitor with an IC50 value of 0.23 mM.
T40576	(S)-Salsolidine
	(S)-Salsolidine, a chemical compound, functions as a weak inhibitor of monoamine oxidase (MAO), exhibiting an inhibition constant (K i ) of 63 μM. R enantiomer demonstrating a greater efficacy than (S)-Salsolidine, boasting a K i value of 26 μM compared to the S form.
TN3726	Cudraflavone B	IκB/IKK; MAO; ROS; Akt; COX; PI3K; Nrf2; Autophagy	Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling
	Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mouse melanoma cells, and hepatoprotective activity. It may be a lead for the development of a potential candidate for human oral squamous cell carcinoma cells.
T40628	Chrysophanol-1-O-β-gentiobioside
	Chrysophanol-1-O-β-gentiobioside, an anthraquinone glycoside obtained from the seeds of Cassia obtusifolia, exhibits targeted inhibition of hMAO-A isozyme activity with an IC50 value of 96.15 μM.
T36950	Rubrofusarin triglucoside
	Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside inhibits human monoamine oxidase A (hMAO-A) with an IC50 of 85.5 μM[1]. [1]. Pradeep Paudel, et al. Rubrofusarin as a Dual Protein Tyrosine Phosphate 1B and Human Monoamine Oxidase-A Inhibitor: An in Vitro and in Silico Study. ACS Omega. 2019 Jul 3;4(7):11621-11630.

天然产物

Cat.No: T3885

Synonym: 6'-O-Deacetylrosiridoside C,络塞定,(-)-Rosiridin

Target: Others, Monoamine Oxidase

Cat.No: TN2004

Synonym: 1,7-二羟基-2,3,8-三甲氧基-6-甲基蒽-9,10-二酮,决明素

Target: MAO, Monoamine Oxidase

Cat.No: T2900

Synonym: 丹皮酚,Peonol

Target: MAO, Autophagy, Monoamine Oxidase

rosmarinate acid

Cat.No: TN7057

Synonym: (R)-rosmarinic acid,rosmarinic acid,迷迭香素,Rosemary acid

Target: MAO, Endogenous Metabolite, Transferase

Cat.No: T5648

Synonym: 吡啉,1,2,4-Trihydroxyanthraquinone,Hydroxylizaric acid,Verantin

Target: MAO, Antibacterial, Antibiotic, Antifungal

Cat.No: T3933

Synonym: Yatrorizine,neprotin,药根碱

Target: MAO, 5-HT Receptor, Antibacterial, AChE

Cat.No: T4024

Synonym: 2-Azacarbazole,2,9-Diazafluorene,β-Carboline,去甲哈尔满

Target: DNA, Endogenous Metabolite, Monoamine Oxidase

Rosmarinic acid

Cat.No: T2765

Synonym: Labiatenic acid,迷迭香酸,Rosemary acid

Target: Apoptosis, IκB/IKK, MAO, Endogenous Metabolite, Transferase, Monoamine Oxidase

4-Hydroxyderricin

Cat.No: T10146

Target: Dehydrogenase, MAO

Cat.No: TN1470

Synonym: 决明子苷B2

Target: Phosphatase, MAO, 5-HT Receptor

Cat.No: T3158

Synonym: Loturine,Harman,Aribine,哈尔满碱

Target: Adrenergic Receptor, Monoamine Oxidase, Imidazoline Receptor

Cat.No: T6862

Synonym: Pseudoisatin,板蓝根,Indoline-2,3-dione,2,3-Indolinedione

Target: Apoptosis, MAO, Monoamine Oxidase

Cat.No: TN1120

Target: MAO, Monoamine Oxidase

4-aminobenzoic acid

Cat.No: T1311

Synonym: PABA,Vitamin H1,Vitamin Bx,para-Aminobenzoic acid,对氨基苯甲酸

Target: Endogenous Metabolite

Cat.No: T1711

Synonym: Telepathine,去氢骆驼蓬碱

Target: MAO, 5-HT Receptor, DYRK

Cat.No: T3822

Synonym: Bellidifoline,龙胆山酮酚,Bellidifolium,雏菊叶龙胆酮

Target: Others, HIV Protease

Desmethoxyyangonin

Cat.No: T5S0734

Synonym: Desmethoxy yangonin,去甲氧基醉椒素,Demethoxyyangonin,5,6-Dehydrokavain

Target: Others, Monoamine Oxidase

Harmalol hydrochloride

Cat.No: TN1724

Synonym: Harmidol hydrochloride

Target: P450, Antioxidant

8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate

Cat.No: TN3294

Target: NADPH-oxidase, P450, MAO

Methyl piperate

Cat.No: T79979

Target: Monoamine Oxidase

1-Methyl-2-undecyl-4(1H)-quinolone

Cat.No: TN2553

Synonym: 1-Methyl-2-undecylquinolin-4(1H)-one

Target: MAO

Dihydroevocarpine

Cat.No: TN1099

Target: MAO, P-gp, Antifection

8alpha-Tigloyloxyhirsutinolide 13-O-acetate

Cat.No: TN3300

Target: NADPH-oxidase, P450, MAO

Cat.No: T40244

(S)-Salsolidine

Cat.No: T40576

Cat.No: TN3726

Target: IκB/IKK, MAO, ROS, Akt, COX, PI3K, Nrf2, Autophagy

Chrysophanol-1-O-β-gentiobioside

Cat.No: T40628

Rubrofusarin triglucoside

Cat.No: T36950

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