Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(±)-Amiflamine (2-dimethylphenethylamine) 是一种单胺氧化酶(MAO-A),pIC50=5.57。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 3,980 | 现货 | ||
5 mg | ¥ 8,730 | 现货 | ||
10 mg | ¥ 11,700 | 现货 | ||
25 mg | ¥ 17,300 | 现货 | ||
50 mg | ¥ 23,500 | 现货 | ||
100 mg | ¥ 31,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 8,130 | 现货 |
产品描述 | (±)-Amiflamine (2-dimethylphenethylamine) is an inhibitor of reversible MAO-A. |
体外活性 | The ex vivo approach was found to be valid for moclobemide in brain and liver and for cimoxatone in brain tissue;?a slight underestimation of the MAO A inhibitory effect of the latter in the liver is likely.?Definite underestimation occurred with amiflamine in both tissues.?Kinetic investigations using homogenates from pretreated rats showed amiflamine to be a competitive inhibitor;?cimoxatone was competitive in the liver but showed a more complex pattern in the brain.?Moclobemide was noncompetitive in both tissues, as has been shown previously for brofaremine.?Moclobemide prevented the deamination of dopamine and serotonin released from their striatal stores by tetrabenazine nearly as efficiently as clorgyline at an otherwise equieffective dose;?cimoxatone was somewhat less effective relative to the reference compound, as was brofaremine, which was however given at a more effective dose.?Amiflamine was much less effective than clorgyline at protecting dopamine, but equieffective with respect to serotonin[1]. |
体内活性 | Amiflamine was 3 times less potent within noradrenergic neurons than within serotonergic neurons. A brain to plasma ratio of about 20:1 was found for amiflamine and its metabolites. The plasma and the brain concentrations of the N-demethylated metabolite [FLA 788(+)] exceeded that of amiflamine after a single dose, whereas the N,N-demethylated [FLA 668(+)] was found in low concentrations. The effect on MAO-A correlated significantly with the plasma and the brain concentration of FLA 788(+)[2]. |
别名 | 4-(dimethylamino)-alpha, 4-(2-氨基丙基)-N,N,3-三甲基苯胺, Amiflamine, 2-dimethylphenethylamine |
分子量 | 192.3 |
分子式 | C12H20N2 |
CAS No. | 77502-96-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32.5 mg/mL (169 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 5.2002 mL | 26.001 mL | 52.0021 mL | 130.0052 mL |
5 mM | 1.04 mL | 5.2002 mL | 10.4004 mL | 26.001 mL | |
10 mM | 0.52 mL | 2.6001 mL | 5.2002 mL | 13.0005 mL | |
20 mM | 0.26 mL | 1.3001 mL | 2.6001 mL | 6.5003 mL | |
50 mM | 0.104 mL | 0.52 mL | 1.04 mL | 2.6001 mL | |
100 mM | 0.052 mL | 0.26 mL | 0.52 mL | 1.3001 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
(±)-Amiflamine 77502-96-6 Metabolism Neuroscience MAO Monoamine Oxidase FLA 336 4-(dimethylamino)-alpha Inhibitor (±)Amiflamine (±) Amiflamine 4-(2-氨基丙基)-N,N,3-三甲基苯胺 Amiflamine FLA-336 FLA336 2-dimethylphenethylamine inhibit inhibitor