Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rosmarinic acid (Labiatenic acid) 是植物中广泛存在的酚酯化合物,具有抗氧化、抗炎和抗菌活性。它抑制 MAO-A,MAO-B 和 COMT,IC50分别为 50.1,184.6 和 26.7 μM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
20 mg | ¥ 290 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 230 | 现货 |
产品描述 | Rosmarinic acid (Labiatenic acid) has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive performance, Alzheimer′s disease prevention, kideney disease treatment, cardioprotection and c |
靶点活性 | IKK β:12 μM |
体外活性 | Rosmarinic acid (RA) exhibits a multifunctional profile characterized by antioxidant effects, and monoamine oxidases (MAO-A and MAO-B) and catechol-O-methyl transferase (COMT) inhibition in vitro. Rosmarinic acid exhibits antioxidant effects against hydroxyl (HO(•)) and nitric oxide (NO) radicals (IC50 of 29.4 and 140 μM, respectively), and inhibition of lipid peroxidation (IC50 of 19.6 μM)[1]. Rosmarinic acid (RA) exerts a significant cytoprotective effect by scavenging intracellular ROS induced by UVB. In Water2-treated cells, 2.5 μM Rosmarinic acid scavenges 60% of intracellular ROS compared to 77% of intracellular ROS scavenging effect in N-acetyl-L-cysteine (NAC)[2]. |
体内活性 | Rosmarinic acid (RA) is a widespread phenolic ester compound in plants, particularly those in the Labiatae family of herbs, like Rosmarinus officinali, Salvia miltiorrhiza, and Prunella vulgaris. Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice by dual inhibition of NF-κB and STAT3 activation. In the DSS-induced colitis model, Treatment with Rosmarinic acid (30, 60 mg/kg, p.o.) markedly attenuates the production of cytokines[3]. |
细胞实验 | Rosmarinic acid (RA) is dissolved in DMSO and stored, and then diluted with appropriate media before use[2]. Human keratinocytes (HaCaT cells) are treated with Rosmarinic acid (0.625, 1.25, 2.5, or 5 μM) and exposed to UVB radiation 1 h later. They are then incubated at 37°C for 48 h. At this time, MTT is added to each well to obtain a total reaction volume of 200 μL. After 4 h incubation, the supernatant is removed by aspiration. The formazan crystals in each well are dissolved in dimethyl sulfoxide (DMSO; 150 μL), and the absorbance at 540 nm is measured on a scanning multi-well spectrophotometer[2]. |
别名 | Labiatenic acid, 迷迭香酸, Rosemary acid |
分子量 | 360.31 |
分子式 | C18H16O8 |
CAS No. | 20283-92-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 36.03 mg/mL (100 mM), Sonification is recommended
DMSO: 72.07 mg/mL (200 mM), Sonification is recommended
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 2.7754 mL | 13.8769 mL | 27.7539 mL | 69.3847 mL |
5 mM | 0.5551 mL | 2.7754 mL | 5.5508 mL | 13.8769 mL | |
10 mM | 0.2775 mL | 1.3877 mL | 2.7754 mL | 6.9385 mL | |
20 mM | 0.1388 mL | 0.6938 mL | 1.3877 mL | 3.4692 mL | |
50 mM | 0.0555 mL | 0.2775 mL | 0.5551 mL | 1.3877 mL | |
100 mM | 0.0278 mL | 0.1388 mL | 0.2775 mL | 0.6938 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Rosmarinic acid 20283-92-5 Apoptosis Metabolism Neuroscience NF-Κb IκB/IKK MAO Endogenous Metabolite Transferase Monoamine Oxidase inhibit Inhibitor Labiatenic acid 迷迭香酸 Rosemary acid COMT inhibitor