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Rosmarinic acid

Rosmarinic acid

产品编号 T2765   CAS 20283-92-5
别名: Labiatenic acid, 迷迭香酸, Rosemary acid

Rosmarinic acid (Labiatenic acid) 是植物中广泛存在的酚酯化合物,具有抗氧化、抗炎和抗菌活性。它抑制 MAO-A,MAO-B 和 COMT,IC50分别为 50.1,184.6 和 26.7 μM。

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Rosmarinic acid Chemical Structure
Rosmarinic acid, CAS 20283-92-5
规格 价格/CNY 货期 数量
20 mg ¥ 290 现货
1 mL * 10 mM (in DMSO) ¥ 230 现货
其他形式的 Rosmarinic acid:
产品目录号及名称: Rosmarinic acid (T2765)
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选择批次  
纯度: 99.73%
纯度: 99.47%
纯度: 98.19%
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
植物来源
结构类型
产品描述 Rosmarinic acid (Labiatenic acid) has shown to contain antioxidant, anti-inflammatory and antimicrobial activities. Possesses promising physiological actions related to cognitive performance, Alzheimer′s disease prevention, kideney disease treatment, cardioprotection and c
靶点活性 IKK β:12 μM
体外活性 Rosmarinic acid (RA) exhibits a multifunctional profile characterized by antioxidant effects, and monoamine oxidases (MAO-A and MAO-B) and catechol-O-methyl transferase (COMT) inhibition in vitro. Rosmarinic acid exhibits antioxidant effects against hydroxyl (HO(•)) and nitric oxide (NO) radicals (IC50 of 29.4 and 140 μM, respectively), and inhibition of lipid peroxidation (IC50 of 19.6 μM)[1]. Rosmarinic acid (RA) exerts a significant cytoprotective effect by scavenging intracellular ROS induced by UVB. In Water2-treated cells, 2.5 μM Rosmarinic acid scavenges 60% of intracellular ROS compared to 77% of intracellular ROS scavenging effect in N-acetyl-L-cysteine (NAC)[2].
体内活性 Rosmarinic acid (RA) is a widespread phenolic ester compound in plants, particularly those in the Labiatae family of herbs, like Rosmarinus officinali, Salvia miltiorrhiza, and Prunella vulgaris. Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice by dual inhibition of NF-κB and STAT3 activation. In the DSS-induced colitis model, Treatment with Rosmarinic acid (30, 60 mg/kg, p.o.) markedly attenuates the production of cytokines[3].
细胞实验 Rosmarinic acid (RA) is dissolved in DMSO and stored, and then diluted with appropriate media before use[2]. Human keratinocytes (HaCaT cells) are treated with Rosmarinic acid (0.625, 1.25, 2.5, or 5 μM) and exposed to UVB radiation 1 h later. They are then incubated at 37°C for 48 h. At this time, MTT is added to each well to obtain a total reaction volume of 200 μL. After 4 h incubation, the supernatant is removed by aspiration. The formazan crystals in each well are dissolved in dimethyl sulfoxide (DMSO; 150 μL), and the absorbance at 540 nm is measured on a scanning multi-well spectrophotometer[2].
别名 Labiatenic acid, 迷迭香酸, Rosemary acid
分子量 360.31
分子式 C18H16O8
CAS No. 20283-92-5

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: 36.03 mg/mL (100 mM), Sonification is recommended

DMSO: 72.07 mg/mL (200 mM), Sonification is recommended

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.7754 mL 13.8769 mL 27.7539 mL 69.3847 mL
5 mM 0.5551 mL 2.7754 mL 5.5508 mL 13.8769 mL
10 mM 0.2775 mL 1.3877 mL 2.7754 mL 6.9385 mL
20 mM 0.1388 mL 0.6938 mL 1.3877 mL 3.4692 mL
50 mM 0.0555 mL 0.2775 mL 0.5551 mL 1.3877 mL
100 mM 0.0278 mL 0.1388 mL 0.2775 mL 0.6938 mL

计算器

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分子量计算器
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参考文献

1. Andrade JM, et al. Combining in vitro and in silico approaches to evaluate the multifunctional profile of rosmarinic acid from Blechnum brasiliense on targets related to neurodegeneration. Chem Biol Interact. 2016 Jul 25;254:135-45. 2. Fernando PM, et al. Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells. Biomol Ther (Seoul). 2016 Jan;24(1):75-84. 3. Jin, B., Chung, K., Cheon, S., Lee, M., Hwang, S., & Noh Hwang, S. et al. (2017). Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation. Scientific Reports, 7(1). doi: 10.1038/srep46252 4. Shim K S, Hwang Y H, Jang S A, et al. . Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice[J]. Nutrients.  2020, 12(7): 1927.

文献引用

1. Jang S A, Hwang Y H, Yang H, et al. Water Extract of Mentha arvensis L. Attenuates Estrogen Deficiency-Induced Bone Loss by Inhibiting Osteoclast Differentiation. Frontiers in Pharmacology. 2021, 12. 2. Shim K S, Hwang Y H, Jang S A, et al.  Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice. Nutrients. 2020, 12(7): 1927 3. Zhang H, Liang B, Sang X, et al.Discovery of Potential Inhibitors of SARS-CoV-2 Main Protease by a Transfer Learning Method.Viruses.2023, 15(4): 891. 4. Quan W, Wang Y, Chen Y, et al.Screening of rosmarinic acid from Salvia miltiorrhizae acting on the novel target TRPC1 based on the ‘homology modelling–virtual screening–molecular docking–affinity assay–activity evaluation’method.Pharmaceutical Biology.2023, 61(1): 155-164. 5. Li X W, Yuan S C, Wang M, et al.Rosmarinic acid ameliorates autoimmune responses through suppression of intracellular nucleic acid-mediated type I interferon expression.Biochemical and Biophysical Research Communications.2023 6. Othman N M, Elhawary Y M, Elbeltagy M G, et al.The Effect of Rosmarinus Officinalis as a Potential Root Canal Medication on the Viability of Dental Pulp Stem Cells.The Journal of Contemporary Dental Practice.2023, 24(9): 623-631.
CHBO4 Rasagiline Mesylate Ladostigil Hydroxyamine hydrochloride RN-1 dihydrochloride Minaprine dihydrochloride AnnH31 Minaprine

相关化合物库

该产品包含在如下化合物库中:
抗癌药物库 烟草单体化合物库 抗癌临床化合物库 神经退行性疾病化合物库 苗药化合物库 已知活性化合物库 抗肝癌化合物库 药物功能重定位化合物库 抗抑郁症化合物库 中国药典收录天然产物库

剂量换算

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体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
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第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Rosmarinic acid 20283-92-5 Apoptosis Metabolism Neuroscience NF-Κb IκB/IKK MAO Endogenous Metabolite Transferase Monoamine Oxidase inhibit Inhibitor Labiatenic acid 迷迭香酸 Rosemary acid COMT inhibitor

 

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