Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Indantadol HCl (CHF-3381) 是一种 NMDA 拮抗剂和非选择性 MAO 抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,300 | 现货 | ||
5 mg | ¥ 2,920 | 现货 | ||
10 mg | ¥ 4,290 | 现货 | ||
25 mg | ¥ 6,890 | 现货 | ||
50 mg | ¥ 9,320 | 现货 | ||
100 mg | ¥ 12,500 | 现货 | ||
500 mg | ¥ 24,900 | 现货 |
产品描述 | Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor. |
体内活性 | In a human heat-capsaicin-induced pain model, Indantadol HCl at a dose of 500 mg effectively reduced the area of secondary hyperalgesia to 67%. Indantadol HCl undergoes extensive liver metabolism, withthe formation of two major metabolites - CHF-3567 and 2-aminoindane. The drug is excreted in urine partially as the parent compound, but mostly as CHF-3567. The tolerability profile of Indantadol HCl at single doses up to 600 mg and twice-daily doses up to 400 mg in clinical trials was significantly more favorable than for other NMDA antagonists. Most side effects have been observed to be mild, and include dizziness and asthenia. Indantadol HCl is currently in phase II clinical trials in patients with diabetic peripheral neuropathic pain.[1] |
别名 | CHF-3381, CMP-3381, GT-3381, V-3381, CNP-3381, Indantadol |
分子量 | 226.7 |
分子式 | C11H15ClN2O |
CAS No. | 202914-18-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (220.56 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.4111 mL | 22.0556 mL | 44.1112 mL | 110.2779 mL |
5 mM | 0.8822 mL | 4.4111 mL | 8.8222 mL | 22.0556 mL | |
10 mM | 0.4411 mL | 2.2056 mL | 4.4111 mL | 11.0278 mL | |
20 mM | 0.2206 mL | 1.1028 mL | 2.2056 mL | 5.5139 mL | |
50 mM | 0.0882 mL | 0.4411 mL | 0.8822 mL | 2.2056 mL | |
100 mM | 0.0441 mL | 0.2206 mL | 0.4411 mL | 1.1028 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Indantadol HCl 202914-18-9 Metabolism Neuroscience MAO NMDAR CNP3381 CHF 3381 GT3381 CMP3381 CHF-3381 V3381 CMP 3381 CMP-3381 CNP 3381 GT-3381 GT 3381 CHF3381 V-3381 CNP-3381 V 3381 Indantadol Inhibitor inhibitor inhibit