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Search Results for " hct116?cells "

58

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9810	TNIK-IN-5	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	TNIK-IN-5 是高效的 TNIK 抑制剂 (IC50= 0.05 μM)。TNIK-IN-5 可以有效抑制细胞中的 Wnt 信号通路。TNIK-IN-5 在体外显示出良好的抗结直肠癌活性。
T6255	Bromosporine	Epigenetic Reader Domain; CDK	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Bromosporine 是广谱 BRD2/4/9 和 CECR2 溴结构域抑制剂，IC50为0.41、0.29、0.122和0.017 μM。
T21854	Proteasome inhibitor IX PS-IX,AM114	Proteasome	Proteases/Proteasome; Ubiquitination
	Proteasome inhibitor IX (PS-IX) 是 Chalcone 的一种衍生物，对20S 蛋白酶体的胰凝乳蛋白酶样活性有抑制作用，IC50约为 1 μM。它抑制 HCT116 p53+/+细胞生长，IC50为 1.49 μM，显示出有效的抗癌活性。
T36970	STD1T	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	STD1T 是一种具有选择性和有效性的脱泛素酶 USP2a 抑制剂，具有潜在的抗癌活性，可降低 HCT116 结肠和 MCF-7 乳腺癌细胞中的细胞周期蛋白 D1 蛋白水平。
T24131	HDAC3-IN-T247 HDAC3 inhibitor T247,HDAC3 inhibitor-T247,HDAC3 IN T247,T247	Histone Demethylase; Antiviral	Chromatin/Epigenetic; Immunology/Inflammation
	HDAC3-IN-T247 (HDAC3 inhibitor T247) 是一种具有选择性和有效性的组蛋白去乙酰化酶 3（HDAC3）抑制剂，具有抗癌和抗病毒活性。HDAC3-IN-T247 以剂量依赖的方式诱导人结肠癌 HCT116 细胞中 NF-κB 乙酰化。HDAC3-IN-T247 抑制癌细胞增殖。
T78156	MC4033	Apoptosis	Apoptosis
	MC4033是一种选择性的，可逆的KAT8赖氨酸乙酰转移酶抑制剂，IC50为12.1μM，具有抗癌活性，并能诱导凋亡(apoptosisautophagy)。
T5699	SSE15206	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	SSE15206 是一种克服多药耐药性的微管聚合抑制剂，其在 HCT116 细胞中的 GI50值为 197 nM。由于癌细胞中纺锤体形成不完整，导致 G2/M 停滞，有丝分裂异常。
T13436	(E)-[6]-Dehydroparadol (6)-Dehydroparadol	Nrf2	Immunology/Inflammation
	(E)-[6]-Dehydroparadol ((6)-Dehydroparadol) 是 [6]-Shogaol 的氧化代谢产物，是有效的 Nrf2 活化剂。
T9575	MRTX9768	Histone Methyltransferase	Chromatin/Epigenetic
	MRTX-9768 是一种有效的、选择性的、具有口服活性的 PRMT5-MTA 复合体抑制剂，可选择性靶向 MTAP/CDKN2A 缺失的肿瘤。
T22632	TASIN-1 1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine,塔辛-1	APC	Cell Cycle/Checkpoint
	TASIN-1 是截短的APC 基因（结肠腺瘤样息肉基因）选择性抑制剂，可以抑制胆固醇生物合成并发挥细胞毒性作用。它是一种预防和干预APC 突变型结直肠癌的潜在治疗策略。
T9557	TNIK-IN-2	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	TNIK-IN-2 是有效的TNIK 抑制剂，IC50为 1.3337 μM。
T78157	PARP-1-IN-3	Apoptosis; PARP	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	PARP-1-IN-3 是一种高效的 PARP-1 抑制剂，对 PARP-1 和 PARP-2 具有抑制作用， IC50 值分别为 0.25 nM 和 2.34 nM。PARP-1-IN-3 具有潜在的抗炎活性，促使细胞凋亡并使细胞周期停滞在 G2/M 期。PARP-1-IN-3 可用于研究与癌症相关的疾病。
T64391	Antiproliferative agent-15	Others	Others
	Antiproliferative agent-15是一种具有抗癌活性的试剂。Antiproliferative agent-15对人结肠癌(HCT116和HCT15)和脑癌(LN-229和GBM-10)具有抗增殖活性。
T11421	Glutaminase-IN-1 CB839 derivative	transporter	Metabolism
	Glutaminase-IN-1 (CB839 derivative)，是一种新型 1,3,4-硒二氮基肾型谷氨酰胺酶(KGA) 的变构抑制剂，在侵袭性 H22 肝癌异种移植模型中显示出抗肿瘤活性。
T83079	Anticancer agent 172
	Anticanceragent 172 (8d) 具有显著的抗癌活性，在 HCT116 细胞中表现出 6.96 μM 的 IC50 值。
T71815	TX-1918
	TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K). TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells.
T37010	D-threo Sphinganine (d18:0) D-threo Sphinganine (d18:0)
	D-threo Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and L-erythro sphinganine (d18:0) . It induces autophagy in HCT116 cells when used at a concentration of 12 μM. D-threo Sphinganine (d18:0) is metabolized via sphinganine N-acyltransferase and sphinganine kinase in vivo in rat liver.
T63509	Top/HDAC-IN-1
	Top/HDAC-IN-1 是拓扑异构酶 (Top)/HDAC 双重抑制剂，能够作用于 HDAC1 (IC50: 18 nM)、HDAC2 (IC50: 230 nM)、HDAC3 (IC50: 790 nM)、HDAC6 (IC50: 87 nM) 和 HDAC8 (IC50: 5250 nM)。Top/HDAC-IN-1 对 HCT116 细胞表现出有效的抗肿瘤作用 (IC50: 180 nM)，可将 HCT116 细胞的细胞周期阻滞 G2 期，有效诱导其凋亡 (apoptosis)。
T74455	JPS035
	JPS035 是一种基于苯甲酰胺的Von Hippel-Lindau (VHL)E3-连接酶蛋白水解靶向嵌合体 (PROTAC)。JPS035 降解 I 类组蛋白脱乙酰酶 (HDAC)。JPS035 是一种有效的 HDAC1/2 降解剂，与 HCT116 细胞中更大的总差异表达基因和增强的细胞凋亡 (apoptosis) 相关。
T35607	10'-Desmethoxystreptonigrin
	10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin. It is active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1 and 0.4 μg/ml, respectively). 10'-Desmethoxystreptonigrin is cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 μg/ml, respectively), as well as HCT116 cells resistant to etoposide and tenipo...
T72544	4-Formylcolchicine
	4-Formylcolchicine 为一有效抗癌化合物，展示对 A549、HT-29、HCT116 细胞具有细胞毒性活性，其 IC50 值分别为 1.007 µM、0.128 µM、0.054 µM。
T37644	Bengamide B
	Potent inhibitor of NF-κB activation (IC50 = 85 nM); decreases IκBα phosphorylation. Attenuates LPS-induced nitric oxide production and expression of TNF-α, IL-6 and MCP. Suppresses proliferation of HeLa and HCT116 cells. Anti-inflammatory and antitumor. Hu et al (2007) Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem.Biol. 14 764 PMID:17656313 \|Johnson et al (2012) Myxobacteria versus sponge-derived alkaloids: the be...
T62349	Tubulin polymerization-IN-8
	Tubulin aggregation-IN-8 (compound IIc) 是一种有效的tubulin 聚合抑制剂。Tubulin aggregation-IN-8 浓度依赖性地导致 HCT116 肿瘤细胞 G2/M 期细胞周期停滞，并显示显着抑制微管蛋白聚合，IC50值为 12.7 μM。Tubulin aggregation-IN-8 具有研究癌症疾病的潜力。
T83080	Anticancer agent 171
	Anticanceragent 171（Compound 6a）是一款肟类似物，对HCT116细胞表现出显著的抗癌活性，IC50值为3.43 μM，主要用于癌症研究领域。
T36464	Caylin-1
	Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, caylin-1 inhibits the growth of HCT116 cells with an IC50 value of approximately 7 μM, making it about 7-fold less potent than nutlin-3 in the same assay. Interestingly, at ...
T63383	SZ-015268
	SZ-015268 是 CDK7 抑制剂 (IC50: 23.56 nM)，对HCC70 (IC50: 33 nM)、OVCAR-3 (IC50: 80.56 nM)、HCT116 (IC50: 12.53 nM) 和 HCC1806 (IC50: 61.55nM) 细胞增殖具有抑制作用。SZ-015268 表现出极显着的抗肿瘤作用。
T37584	Tryptoquivaline D
	Tryptoquivaline D is a fungal metabolite that has been found inNeosartorya siamensisand has anticancer activity.1,2It induces nuclear chromatin condensation, a marker of apoptosis, in HCT116 colon and HepG2 liver cancer cells when used at a concentration of 150 μM.1Tryptoquivaline D (1-100 μM), alone or in combination with doxorubicin , reduces the viability of A549 lung cancer cells.2
T83090	Anticancer agent 131
	HCT-116-IN-1, 一种与γ-内酰胺融合的吡啶酮衍生物，展现了针对HCT116细胞的强抗癌活性，其细胞毒性测定显示IC50值为5.59 μM。
T36627	Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)
	Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).1,2LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 μM.1It increases the level of H3K4 methylation, including H3K4me1 and H3K4me2 but not H3K9me2 levels, in HCT116 human colon carcinoma cells.2LSD inhibitor (1C) also induces re-expression of the Wnt signaling pathway proteins secreted frizzle-related protei...
T36465	Caylin-2
	Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-2 is a nutlin-3 analog in which trifluoromethyl groups have been substituted for chlorine on the 2 phenyl rings. At high concentrations, caylin-2 inhibits the growth of HCT116 cells with an IC50 of approximately 8 μM, making it about 10-fold less potent than nutlin-3. Interestingly, at concentrations between 5-100 nM, caylin-2 promotes the growth of HCT116 c...
T83011	Antitumor agent-105
	Antitumor agent-105（Compound 37）是一种对A549、H1299、H460、HCT116、MDA-MB-231细胞线显示出抗肿瘤活性的化合物，其IC50值分别为6.7、8.3、4.3、4.4、6.7μM。
T39200	β-catenin-IN-37
	β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of colorectal cancer cells SW480 and HCT116, with IC50 values of 20 μM and 31 μM, respectively.
T81740	Multi-kinase-IN-6	Trk receptor	Tyrosine Kinase/Adaptors
	Multi-kinase-IN-6 (compound 10e) 是一种效能极高的多激酶抑制剂，具有对 TrkA、ALK2、c-KIT、EGFR、PIM1、CK2α、CHK1 和 CDK2 等多种酶的显著抑制作用。在 MCF7、HCT116 和 EKVX 癌细胞系上，其抗增殖活性突出，IC50 值分别达到 3.36 μM、1.40 μM 与 3.49 μM。此外，Multi-kinase-IN-6 能引起 MCF7 与 HCT116 细胞的细胞周期在 G1/S 期及 G1 期停滞，并有效诱导凋亡。
T38381	CAY17c
	CAY17c is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50= 0.71 μM), as well as class I histone deacetylases (HDACs; IC50s = 0.046, 0.058, 0.075, and 0.167 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 0.073 and 0.923 μM for HDAC6 and HDAC10, respectively).1It is selective for these enzymes over BRD2, -3, and -T (IC50s = >20 μM for all), as well as over HDAC4, -5, -7, -9, and -11 (IC50s = >10 μM for all). CAY17c inhibits the proliferation of HCT116, SW620,...
T13643	Demethoxydeacetoxypseudolaric acid B analog 脱甲氧基脱乙酰土槿皮乙酸,去甲氧基去乙酰氧基土槿甲酸B类似物	Others	Others
	Demethoxydeacetoxypseudolaric acid B analog 是由 Pseudolaric acid B 半合成得到，能够有效抑制 HMEC-1、HL-60、A-549、MB-MDA-468、BEL-7402、HCT116、Hela 细胞，且 IC50值范围为 0.136-1.162 μM。
T74454	JPS016
	JPS016 是一种基于苯甲酰胺的Von Hippel-Lindau (VHL)E3-连接酶蛋白水解靶向嵌合体 (PROTAC)。JPS016 降解 I 类组蛋白脱乙酰酶 (HDAC)。JPS016 是一种有效的 HDAC1/2 降解剂，与 HCT116 细胞中更大的总差异表达基因和增强的细胞凋亡 (apoptosis) 相关。
T74453	JPS014
	JPS014, 基于苯甲酰胺的Von Hippel-Lindau (VHL) E3-连接酶蛋白水解靶向嵌合体 (PROTAC)，有效降解I 类组蛋白脱乙酰酶 (HDAC)。它作为HDAC1/2的强效降解剂，与HCT116细胞中的总差异表达基因更大和增强的细胞凋亡 (apoptosis) 密切相关。
T77937	JPS014 TFA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	JPS014 TFA是一种VHL E3连接酶蛋白水解靶向嵌合体(PROTAC)，以苯甲酰胺为基础，专门降解I类组蛋白脱乙酰酶(HDAC)。作为一种高效的HDAC1/2降解剂，JPS014 TFA与HCT116细胞中广泛的基因表达差异及促进细胞凋亡(apoptosis)密切相关。
T61996	Antiproliferative agent-6
	Antiproliferative agent-6 (compound 8a) 是有效的抗肿瘤化合物。Antiproliferative agent-6 具有抗增殖活性，抑制癌细胞系 HCT116、MCF-7、H460 和非肿瘤非整倍体永生角质细胞 HaCaT 的 GI50分别为 0.5 μM、2 μM、0.7 μM 和 3.5 μM。
T62943	ZLWT-37
	ZLWT-37 是一种有效的、口服具有活力的 CDKs 抑制剂，作用于 CDK9 (IC50: 0.002 μM) 和 CDK2 (IC50: 0.054 μM)。ZLWT-37 能够将 HCT116 细胞的细胞周期阻滞在 G2/M 期，并细胞凋亡。
T62934	ZLHQ-5f
	ZLHQ-5f 是一种 CDK2 和 Topo I 双重抑制剂，作用于 CDK2/CycA2 (IC50: 0.145 μM)。ZLHQ-5f 能够将 HCT116 细胞的细胞周期阻滞在 S 期，并诱导其细胞凋亡，具有良好安全性。
T79724	IGF2BP1-IN-1
	IGF2BP1-IN-1（Compound A11）是一款高效的IGF2BP1抑制剂，对IGF2BP1蛋白有很强的结合能力，KD值仅为2.88 nM。该化合物能显著抑制A549和HCT116癌细胞株的增殖，IC50值分别为9 nM和34 nM，且能诱导癌细胞发生凋亡。此外，IGF2BP1-IN-1在A549异种移植小鼠模型中有效抑制了肿瘤生长。
T74456	JPS036
	JPS036 是一种基于苯甲酰胺的Von Hippel-Lindau (VHL)E3-连接酶蛋白水解靶向嵌合体 (PROTAC)。JPS036 降解 I 类组蛋白脱乙酰酶 (HDAC)。JPS036 是一种有效的 HDAC1/2 降解剂，与 HCT116 细胞中更大的总差异表达基因和增强的细胞凋亡 (apoptosis) 相关。
T77938	JPS016 TFA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	JPS016 TFA是一种苯甲酰胺基Von Hippel-Lindau (VHL) E3连接酶蛋白水解靶向嵌合体(PROTAC)。该化合物能够降解I类组蛋白脱乙酰酶(HDAC)，特别是有效地降解HDAC1/2。在HCT116细胞中，JPS016 TFA与大量差异基因表达增加及细胞凋亡(apoptosis)激活相关。
T35668	Neoaureothin
	Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50 = 13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg/ml, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg/ml) and...
T83949	DC 432
	DC 432是一种强效的N-terminal methyltransferase 1/2 (NTMT1/2) (IC50= 54 nM)肽模拟抑制剂，含有BM30肽和额外五个精氨酸残基。在HCT116细胞中，DC 432处理能够降低调节染色体凝缩1和SET蛋白的N端甲基化水平。该化合物具有细胞渗透性。
T83881	4-(3,4-Difluorobenzo)curcumin CDF
	4-(3,4-Difluorobenzo)curcumin（CDF）是一种具有抗寄生虫和抗癌活性的半合成香豆素。它能减少被T. gondii持鞭毛体和无鞭毛体感染的Vero细胞的数量（EC50s分别为0.8和0.37 µM）。CDF（4和8 µM）通过增强5-氟尿嘧啶和奥沙利铂对化药抵抗性HCT116细胞主要和次要结肠球形成的抑制作用。
T62331	Autophagy-IN-1
	Autophagy-IN-1 是一种有效的细胞自噬 (autophagy) /线粒体自噬 (mitophagy) 抑制剂，能够阻断癌细胞内自噬体-溶酶体融合，并同时选择性地提高自噬通量发挥作用。Autophagy-IN-1 能够阻滞细胞周期，并诱导细胞凋亡 (apoptosis)。Autophagy-IN-1 在 HCT116 小鼠异种移植瘤模型中明显抑制肿瘤生长，且毒性低。Autophagy-IN-1 能够用于研究结直肠癌。
T37050	MPS1/TTK Inhibitor MPS1/TTK Inhibitor
	MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. It inhibits MPS1 phosphorylation of kinetochore scaffold 1 (KNL1) and increases the rate of mitosis and the number of cells entering anaphase within 15 minutes, indicating MPS1 checkpoint inhibition, when used at a concentration of 100 nM. MPS1/TTK inhibitor (50 and 100 nM) increases the number of missegr...
T36645	CAY10763 CAY10763
	CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM...

化合物

Cat.No: T9810

Target: Wnt/beta-catenin

Cat.No: T6255

Target: Epigenetic Reader Domain, CDK

Proteasome inhibitor IX

Cat.No: T21854

Synonym: PS-IX,AM114

Target: Proteasome

Cat.No: T36970

Target: DUB

Cat.No: T24131

Synonym: HDAC3 inhibitor T247,HDAC3 inhibitor-T247,HDAC3 IN T247,T247

Target: Histone Demethylase, Antiviral

Cat.No: T78156

Target: Apoptosis

Cat.No: T5699

Target: Apoptosis, Microtubule Associated

(E)-[6]-Dehydroparadol

Cat.No: T13436

Synonym: (6)-Dehydroparadol

Target: Nrf2

Cat.No: T9575

Target: Histone Methyltransferase

Cat.No: T22632

Synonym: 1-[(4-methoxyphenyl)sulfonyl]-4'-methyl-4,1'-bipiperidine,塔辛-1

Target: APC

Cat.No: T9557

Target: Wnt/beta-catenin

Cat.No: T78157

Target: Apoptosis, PARP

Antiproliferative agent-15

Cat.No: T64391

Target: Others

Glutaminase-IN-1

Cat.No: T11421

Synonym: CB839 derivative

Target: transporter

Anticancer agent 172

Cat.No: T83079

Cat.No: T71815

D-threo Sphinganine (d18:0)

Cat.No: T37010

Synonym: D-threo Sphinganine (d18:0)

Cat.No: T63509

Cat.No: T74455

10'-Desmethoxystreptonigrin

Cat.No: T35607

4-Formylcolchicine

Cat.No: T72544

Cat.No: T37644

Tubulin polymerization-IN-8

Cat.No: T62349

Anticancer agent 171

Cat.No: T83080

Cat.No: T36464

Cat.No: T63383

Tryptoquivaline D

Cat.No: T37584

Anticancer agent 131

Cat.No: T83090

Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)

Cat.No: T36627

Cat.No: T36465

Antitumor agent-105

Cat.No: T83011

β-catenin-IN-37

Cat.No: T39200

Multi-kinase-IN-6

Cat.No: T81740

Target: Trk receptor

Cat.No: T38381

Demethoxydeacetoxypseudolaric acid B analog

Cat.No: T13643

Synonym: 脱甲氧基脱乙酰土槿皮乙酸,去甲氧基去乙酰氧基土槿甲酸B类似物

Target: Others

Cat.No: T74454

Cat.No: T74453

Cat.No: T77937

Target: HDAC

Antiproliferative agent-6

Cat.No: T61996

Cat.No: T62943

Cat.No: T62934

Cat.No: T79724

Cat.No: T74456

Cat.No: T77938

Target: HDAC

Cat.No: T35668

Cat.No: T83949

4-(3,4-Difluorobenzo)curcumin

Cat.No: T83881

Synonym: CDF

Cat.No: T62331

MPS1/TTK Inhibitor

Cat.No: T37050

Synonym: MPS1/TTK Inhibitor

Cat.No: T36645

Synonym: CAY10763

Cat. No.	Product Name	Target	Signaling Pathways
T2S0357	6-Hydroxycoumarin 6-hydroxychromen-2-one,6-羟基香豆素	Others; Carbonic Anhydrase	Metabolism; Others
	6-Hydroxycoumarin (6-hydroxychromen-2-one) 是一种香豆素。其中香豆素具有抗炎，支气管扩张，解热，血管扩张，抗氧化，抗菌，抗真菌，抑菌和抗肿瘤作用。
T6S0735	Flavokawain B 黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone	Apoptosis; Others	Apoptosis; Others
	Flavokawain B (Flavokavain B) 是从卡瓦醉椒的根提取物中，分离出的查尔酮。它是一种凋亡诱导剂，可抑制各种癌细胞株生长。它以极低的无毒浓度抑制人脑内皮细胞的迁移和血管形成，具有抗血管生成活性。
TN1440	Beta-Hydroxyisovalerylshikonin	EGFR; Tyrosine Kinases; Prostaglandin Receptor; Src; AMPK; Fatty Acid Synthase	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Beta-hydroxyisovalerylshikonin 是分离自Lithospermium radix 的天然产物，具有抑制PTK 的作用，对 EGFR 和 v-Src 受体作用的IC50分别为 0.7 μM 和 1 μM。它对多种肿瘤细胞系均有抑制作用，可以高效诱导 NCI-H522 和 DMS114 细胞的死亡。
TN3152	6-Acetonyldihydrochelerythrine	ERK; BCL; Akt; HIV Protease; PPAR; p53	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. 6-Acetonyldihydrochelerythrine is
T36815	Chevalone C
	Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). Chevalone C inhibits the growth of multidrug-resistant isolates of E. coli, S. aureus, and E. faecium in a disc diffusion assay when used at a concentration of 15 μg/disc. It also induces cell death in HCT116 colorectal carcinoma cells.

天然产物

6-Hydroxycoumarin

Cat.No: T2S0357

Synonym: 6-hydroxychromen-2-one,6-羟基香豆素

Target: Others, Carbonic Anhydrase

Cat.No: T6S0735

Synonym: 黄卡瓦胡椒素B,Flavokavain B,Flavokawin B,2'-Hydroxy-4',6'-Dimethoxychalcone

Target: Apoptosis, Others

Beta-Hydroxyisovalerylshikonin

Cat.No: TN1440

Target: EGFR, Tyrosine Kinases, Prostaglandin Receptor, Src, AMPK, Fatty Acid Synthase

6-Acetonyldihydrochelerythrine

Cat.No: TN3152

Target: ERK, BCL, Akt, HIV Protease, PPAR, p53

Cat.No: T36815

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