102
12
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21493 |
Cyclosporin H
|
Others | Others |
Cyclosporin H 是一种 FPR-1(甲酰肽受体 1) 的选择性强效抑制剂。它缺乏 Cyclosporin A 具有的免疫抑制活性。它是一种病毒转导增强剂,可使人脐带血来源的造血干细胞和祖细胞中慢病毒转导增强 10 倍。它与雷帕霉素或前列腺素 E2 联合使用时表现出累加效应。 | |||
T21543 |
AP 18
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
AP-18 是选择性的 TRPA1 抑制剂。AP-18 可以抑制 50 μM 肉桂醛诱导的 TRPA1 激活,在小鼠和人中的 IC50 分别为 4.5 μM 和 3.1 μM。AP-18 可以逆转 CFA 诱导的小鼠机械性痛觉过敏。AP-18 可以浓度依赖的方式减弱 30 μM AITC 诱导的 Yo-Pro 摄取(IC50= 10.3 μM)。 | |||
T0097 |
MRT67307
MRT67307 HCl |
IκB/IKK; Autophagy | Autophagy; NF-κB |
MRT67307 是一种IKKε和TBK-1的双抑制剂,IC50分别为 160 和 19 nM。它抑制细胞自噬,也可抑制ULK1和ULK2,IC50分别为 45 和 38 nM。 | |||
T7123 |
AMG-47a
|
VEGFR; p38 MAPK; JAK; Src | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors |
AMG-47a 是具有口服活性的 Lck 抑制剂,IC50值为 0.2 nM。它具有抗炎作用,对 VEGF2、p38α、p38α、Jak3、MLR 和 IL-2的 IC50值分别为 1、3、72、30 和 21 nM。 | |||
T3569 |
SU5214
SU 5214 |
VEGFR; Tyrosinase | Angiogenesis; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
SU5214 (SU 5214) 是 VEGFR2 抑制剂,IC50值为 14.8 µM(FLK-1) 和 36.7 µM (EGFR)。 | |||
T9292 |
ALE-0540
ALE0540 |
Others; Trk receptor | Others; Tyrosine Kinase/Adaptors |
ALE-0540是一种非肽类杂环分子,可抑制NGF 与p75和TrkA 的结合,以及TrkA 受体介导的信号转导和生物反应。 | |||
T2648 |
Pimecrolimus
SDZ-ASM 981,ASM 981,吡美莫司 |
Others | Others |
Pimecrolimus (SDZ-ASM 981) 是一种免疫亲和素配体,能与胞质受体特异性的结合。 | |||
T38617L |
Biotin-TAT (47-57) acetate
Biotin-TAT (47-57) acetate(1231898-25-1 free base) |
Others | Others |
Biotin-TAT (47-57) acetate 是一种生物素标记的 TAT 多肽和转录反式激活因子。 Biotin-TAT (47-57) acetate 是蛋白质转导结构域中使用广泛的肽之一。 | |||
T40423 |
L48H37
|
||
L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is primarily utilized in sepsis and lung injury research [1]. | |||
T76780 |
Onartuzumab
RG-3638,PRO-14396,MetMAb |
c-Met/HGFR | Tyrosine Kinase/Adaptors |
Onartuzumab (MetMAb) 是一种人源化抗酪氨酸激酶 c-MET 单价单克隆抗体。Onartuzumab 具有抗肿瘤活性,对 HGF 结合、受体磷酸化和信号转导有抑制作用。 | |||
T3455 |
Merestinib
LY2801653 |
Discoidin Domain Receptor (DDR); FLT; c-Met/HGFR; ROS; ROS Kinase | Angiogenesis; Immunology/Inflammation; Tyrosine Kinase/Adaptors |
Merestinib (LY2801653) 是一种有效的口服生物可利用的具有抗肿瘤活性的c-Met 抑制剂。 | |||
T76724 |
Nemolizumab
CIM331 |
Interleukin | Immunology/Inflammation |
Nemolizumab (CIM331) 是一种人源化的抗人白细胞介素-31 受体 a 单克隆抗体,对白细胞介素-31 (IL-31) 与其受体的结合和随后的信号转导有抑制作用。Nemolizumab 可用于研究特应性皮炎伴瘙痒。 | |||
T61111 |
UCB-5307
|
TNF | Apoptosis |
UCB-5307 是一种小分子化合物,可在体外抑制 TNFR1 信号转导和下游功能。 人 TNFα 的 KD 为 9 nM。 TNF 直接通过缓慢的结合动力学结合,KD = 6 nM。 UCB-5307 可以通过预制的 hTNF/hTNFR1 复合物。 | |||
T41094 |
Wnt/β-catenin agonist 2
|
GSK-3; Wnt/beta-catenin | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells |
Wnt/β-catenin agonist 2激活 Wnt/β-catenin 信号传导,是一种有效的 Wnt 激动剂。 Wnt/β-catenin agonist 2可用于与信号转导相关的疾病研究,与癌症侵袭转移密切相关。 | |||
T6271 |
Tipifarnib
替吡法尼,R115777,Zarnestra,IND 58359 |
Transferase | Metabolism |
Tipifarnib (IND 58359) 能够抑制法尼基转移酶 (FTase),IC50=0.86 nM,具有潜在抗肿瘤特性。 | |||
T2307 |
Icotinib Hydrochloride
埃克替尼盐酸盐,盐酸埃克替尼,BPI-2009H |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Icotinib Hydrochloride (BPI-2009H) 是一种口服的基于喹唑啉的表皮生长因子受体 (EGFR) 抑制剂,IC50值为5 nM,具有潜在的抗肿瘤活性。 | |||
T2078 |
Fimepinostat
CUDC-907,PI3K/HDAC Inhibitor,CUDC 907 |
Apoptosis; PI3K; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Fimepinostat (CUDC 907) 是一种 I 型PI3K 及 I 和 II 型HDAC 酶抑制剂,作用于 PI3Kα/PI3Kβ/PI3Kδ 和 HDAC1/HDAC2/HDAC3/HDAC10 ,IC50分别为 19/54/39 nM 和 1.7/5.0/1.8/2.8 nM。 | |||
T35349 |
CU-CPD107
CU-CPD107 |
TLR | Immunology/Inflammation |
CU-CPD107是一种 toll-like receptor 8 (TLR8)的选择性激动剂,对ssRNA 配体也表现出激活活性。在R848存在的情况下,CU-CPD107是TLR8信号抑制剂 (IC50=13.7 μM)。在ssRNA 存在的情况下,CU-CPD107表现出协同激动剂活性,而CU-CPD107单独不影响TLR8信号转导。 | |||
TP1991L |
M 1145 acetate
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
M1145 acetate 是一种嵌合肽,是一种选择性甘丙肽受体 2 (GAL2) 激动剂,Ki 为 6.55 nM。它对 GAL2 的亲和力比 GAL1 高 90 倍以上(Ki=587 nM),比 GalR3 的亲和力高 76 倍(Ki=497 nM)。 它对甘丙肽的信号转导具有累加作用。 | |||
T14871 |
Carboxyamidotriazole Orotate
L-651582 Orotate,CAI Orotate |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Carboxyamidotriazole Orotate (L-651582 Orotate) 是一种可口服的信号转导抑制剂,是Carboxyamidotriazole (CAI) 的乳清酸盐形式。它是一种非电压性钙通道和钙通道介导的信号通路的细胞抑制剂,具有抗癌、抗炎活性和抗血管生成作用。 | |||
T22796 |
Galiellalactone
|
Others | Others |
inhibits IL-6-mediated JAK/STAT signal transduction | |||
T38617 |
Biotin-TAT (47-57)
|
||
Biotin-TAT (47-57) is a biotin-tagged transactivator of transcription, commonly employed as a protein transduction domain (PTD) in various primary cells. Its transduction capacity is contingent on ATP and temperature, suggesting the participation of endocytosis. | |||
T31159 |
Cysteinesulfenic acid
L-Alanine, 3-sulfeno-,L-Cysteine sulfoxide,L-Cysteinesulfenic acid,S-(Propylcarbamoyl)cysteine |
||
Cysteinesulfenic acid is a protein-sulfenic acid involved in enzyme catalysis, redox regulation, and signal transduction. | |||
T68442 | Desacetylravidomycin | ||
Desacetylravidomycin is a new inhibitor of IL-4 signal transduction, produced by Streptomyces sp. WK-6326. | |||
T69626 |
L6H21
|
||
L6H21 is an inhibitor of the interaction and signaling transduction of LPS-TLR4/MD-2 (myeloid differentiation 2). | |||
T82422 |
F1874-108
|
||
F1874-108是一种油菜素内酯生物合成及信号传导途径的抑制剂。 | |||
T28511 |
Reglitazar
JTT-501,JTT501,PNU-182716,PNU182716,PNU-716 |
||
Reglitazar is a PPARɑ agonist and PPARγ agonist. Reglitazar rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle. Reglitazar improves insulin resistance in genetic and non-genetic insulin-resistant models. | |||
TP1185 |
Cys-TAT(47-57)
Cys-[HIV-Tat (47-57)] |
||
Cys-TAT(47-57) (Cys-[HIV-Tat (47-57)]) is an arginine rich cell penetrating peptide derived from the HIV-1 transactivating protein.This peptide corresponds to the protein transduction domain of the TAT protein. | |||
T74394 | Flupyradifurone | ||
Flupyradifurone 是一种nAChR 激动剂,可干扰害虫中枢神经系统的信号转导,可用作杀虫剂。 | |||
T82612 |
Dansyl ethylenediamine
|
||
Dansyl ethylenediamine是一种用于合成能特异地转导蛋白质结合事件为荧光信号变化的蛋白质印迹聚合物的荧光探针。 | |||
TP1991 |
M1145
M 1145 |
||
Potent and selective galanin receptor 2 (GAL2) agonist (EC50 = 38 nM, Ki values are 6.55, 497 and 587 nM at GAL2, GAL3 and GAL1 respectively). Has an additive effect on the signal transduction of galanin. | |||
T68600 | Enoximone sulfoxide | ||
Enoximone sulfoxide is a selective phosphodiesterase III (PDE3) inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. Enoximone prevents the degradation of cAMP by PDE, which prolongs signal transduction and its subsequent effects. It is used in patients with congestive heart failure. | |||
T61247 |
TRK-IN-16
|
||
TRK-IN-16 (WO2012034091A1, compound X-21) is a highly effective TRK inhibitor, targeting protein kinases that are integral to regulating cell growth, differentiation, and various cellular signal transduction processes. This compound shows great potential for research in TRK-related diseases [1]. | |||
T4402 |
(4-Chloro-thiazol-2-yl)acetic acid
|
Others | Others |
(4-Chloro-thiazol-2-yl)acetic acid 已被用于多种科学研究应用,包括蛋白质折叠、酶抑制和信号转导。 | |||
T61246 | TRK-IN-15 | ||
TRK-IN-15 (WO2012034091A1, compound X-55) is a highly effective inhibitor of TRK, a protein kinase with crucial involvement in the regulation of cellular growth, differentiation, and signal transduction. Offering significant potential for studying TRK-related diseases, TRK-IN-15 holds promise for advancing research in this field [1]. | |||
T74943 | SARS-CoV-2-IN-25 | ||
SARS-CoV-2-IN-25 (Compound CP026) 是一种有效的 SARS-CoV-2刺突伪粒子转导抑制剂,IC50为 1.6 μM。SARS-CoV-2-IN-25 抑制包膜病毒和脂质体。 | |||
T76387 |
Protein kinase C substrate
|
||
Protein kinase C substrate,蛋白激酶C的底物,关键用于蛋白质检测。作为信号转导中重要的调控元素,Protein kinase C通过特定底物的磷酸化作用发挥其功能。 | |||
T69469 |
Panepoxydone
|
||
Panepoxydone 是一种 NF-κB 活化抑制剂。Panepoxydone 通过抑制 IκB 的磷酸化来干扰 NF-κB 介导的信号转导。Panepoxydone 具有抗肿瘤、抗炎、抗疟疾和抗寄生虫活性。 | |||
T37028 |
PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)
PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt) |
||
The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal ... | |||
T78561 | M62812 free base | ||
M62812 (free base) 是一种TLR4信号转导抑制剂,能够抑制内皮细胞和白细胞的活化,有效预防小鼠致死性感染性休克,适用于脓毒症的研究。 | |||
T77176 | Elgemtumab | ||
Elgemtumab(LJM716) 是一种全人IgG 单克隆抗体。Elgemtumab 可特异性结合 HER3,阻断配体依赖性和非依赖性 HER3 信号转导和细胞增殖,具有良好的抗肿瘤潜力。 | |||
T76764 | Tovetumab | ||
Tovetumab (MEDI-575) 为针对PDGFRα的选择性抗体,专一性阻断PDGFRα信号转导。适用于胶质母细胞瘤与非小细胞肺癌(NSCLC)研究。 | |||
T77032 | Imsidolimab | ||
Imsidolimab (ANB 019) 是一种高亲和力、人源化的抗IL-36R 单克隆抗体。Imsidolimab 拮抗IL-36细胞因子信号传导。Imsidolimab 在泛发性脓疱型银屑病 (GPP) 和其他炎症性皮肤病中有潜在应用。 | |||
T61701 | SHP2-IN-9 | ||
SHP2-IN-9 is a potent inhibitor (IC50 = 1.174 μM) specifically targeting the SHP2 protein, displaying improved penetration across the blood-brain barrier. It exhibits a remarkable 85-fold selectivity for SHP2 over SHP1. By inhibiting SHP2-mediated cell signal transduction and impairing cancer cell proliferation, SHP2-IN-9 effectively suppresses the growth of both cervix cancer tumors and glioblastoma in vivo [1]. | |||
T77789 |
Oleoyl-L-alpha-lysophosphatidic acid sodium salt
LPA sodium salt |
||
Oleoyl-L-alpha-lysophosphatidic acid sodium salt为必需的细胞膜生物合成代谢物,可通过与G蛋白偶联受体(GPCR)(即LPA受体)相互作用来介导信号传导,是LPA1和LPA2受体的内源性激动剂。 | |||
T80744 |
Zanolimumab
Anti-Human CD4 Recombinant Antibody |
||
Zanolimumab(Anti-HumanCD4Recombinant Antibody)是靶向CD4的人源单克隆抗体,能有效地抑制T细胞受体(TCR)的信号转导。它在类风湿性关节炎、银屑病、黑色素瘤、皮肤及周围T细胞淋巴瘤的研究中有应用。 | |||
T35933 |
D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt)
D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt),Ins(1,4,5,6)-P4 |
||
D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.[1] D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal tran... | |||
T36939 |
PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt)
PtdIns-(3,4,5)-P3 (1,2-dihexanoyl) (ammonium salt) |
||
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3, also known as PIP3, is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. PIP3 can serve as an anchor for the binding of signal transd... | |||
T36672 |
CAY10561
|
||
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561... | |||
T7005L |
Ulixertinib hydrochloride
Ulixertinib HCl,BVD-523,VRT752271,BVD 523,BVD523,VRT 752271 |
||
Ulixertinib is an inhibitor of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventi |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1417 |
Azadirachtin
|
Apoptosis; Antifection | Apoptosis; Microbiology/Virology |
Azadirachtin 是一种有前途的植物源杀虫剂,能够诱导昆虫 Sf9、SL-1 和 BTI-Tn-5B1-4 细胞凋亡。它广泛用于害虫防治。 | |||
T6S1844 |
Tenacissoside H
Tenacissimoside C,通关藤苷H |
Others | Others |
Tenacissoside H (Tenacissimoside C) 是一种分离自通关藤中的天然产物,具有抗肿瘤作用。 | |||
T3364 |
Veratramine
NSC17821,黎芦碱,NSC23880,藜芦胺 |
Sodium Channel | Membrane transporter/Ion channel |
Veratramine (NSC-23880) 是一种信号转导抑制剂,可作用于肿瘤。 | |||
T3406 |
Kuromanin chloride
Glucocyanidin chloride,Chrysontemin,矢车菊素-3-O-葡萄糖苷,Chrysontemin chloride,Cyanidin 3-O-glucoside chloride |
NF-κB | NF-κB |
Kuromanin chloride (Chrysontemin chloride) 是从桑叶中获得,能够提高血糖浓度、维持脂质代谢平衡,表现出降低肥胖的作用。 | |||
TN1134 |
Euscaphic acid
|
Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling |
Euscaphic acid 是来源于枣的一种三萜,是DNA 聚合酶抑制剂,可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。 | |||
T20879 |
Tacrolimus monohydrate
FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506 |
Phosphatase; Others; Antibacterial; Antibiotic; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Others |
Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物,它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶,从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。 | |||
T2133 |
Adenosine monophosphate
5'-Adenylic acid,5'-腺嘌呤核苷酸,AMP,Adenosine 5'-monophosphate |
Endogenous Metabolite; AMPK | Chromatin/Epigenetic; Metabolism; PI3K/Akt/mTOR signaling |
Adenosine monophosphate (AMP) 是一种嘌呤核糖核苷5'-单磷酸腺苷,是信号转导和调节能量稳态的关键细胞代谢物。它具有EC 3.1.3.11(果糖-二磷酸酶)抑制剂、EC 3.1.3.1(碱性磷酸酶)抑制剂和腺苷A1受体激动剂的作用。 | |||
T4969 |
Guanosine 5'-triphosphate trisodium salt
鸟苷-5'-三磷酸三钠盐,GTP Trisodium salt,5'-GTP trisodium salt |
Endogenous Metabolite | Metabolism |
Guanosine 5'-triphosphate trisodium salt (5'-GTP trisodium salt) 为G蛋白(G proteins)信号转导过程中的活化剂。 | |||
T6S1917 |
Schisandrol B
Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B |
P450; Reactive Oxygen Species; Autophagy | Autophagy; Immunology/Inflammation; Metabolism; NF-κB |
Schisandrol B (Besigomsin) 是华中五味子的主要活性成分,具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生,也抑制 P-糖蛋白和CYP3A 的活性。 | |||
T17273 |
YM-254890
|
Others | Others |
YM-254890 inhibits platelet aggregation induced by ADP by blocking the P2Y1 signal transduction pathway (IC50: below 0.6 μM). YM-254890 is a selective Gαq/11 protein inhibitor. YM-254890 displays no inhibition of other G protein subtypes. | |||
TN1550 |
Danshenxinkun A
丹参新醌甲,丹参新醌A |
Others | Others |
Danshenxinkun A, Danshenxinkun B and Neocryptotanshinone may intervene thrombotic diseases by adjusting the targets mainly involved in pathways of endocrine system, signal transduction, signaling molecules and interaction, cell motility, environmental ada | |||
T4700 |
1,3,5-Trihydroxy-4-prenylxanthone
|
||
1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 valu |