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50

抑制剂 & 化合物

22

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T28628	RVX-297 RVX297	Epigenetic Reader Domain	Chromatin/Epigenetic
	RVX-297 是口服具有活性的，对BD2有选择性的BET 高效抑制剂，作用于BRD2(BD2)、BRD3(BD2)、BRD4(BD2) 的IC50分别为 0.08、0.05、0.02 μM。它能够阻碍多种免疫细胞炎症基因的表达，对临床前模型急性炎症及自身免疫均有效。
T6716	Valsartan Diovan,缬沙坦,Tareg,CGP 48933	RAAS	Endocrinology/Hormones
	Valsartan (CGP 48933) 是一种血管紧张素 II 受体拮抗剂，有用于高血压和心力衰竭的研究潜力。
T2036	6-OAU GTPL5846	GPR	Endocrinology/Hormones; GPCR/G Protein
	6-OAU (GTPL5846) 是 GPR84 的替代激动剂，在 Gqi5 嵌合体存在的情况下，在 HEK293 细胞中激活人 GPR84，在 PI 测定中 EC50 为 105 nM。
T4602	Hydrocortisone hemisuccinate Hydrocortisone 21-he,氢化可的松琥珀酸酯,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate	Glucocorticoid Receptor; Others; Interleukin	Endocrinology/Hormones; Immunology/Inflammation; Others
	Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) 是糖皮质激素，是口服有活性的甾体抗炎剂。它能够降低IL-6(IC50:6.7 μM)、IL-3(IC50:21.4 μM)的生物活性，可用于研究溃疡性结肠炎。
T7317	CU-CPT-9a	TLR	Immunology/Inflammation
	CU-CPT-9a 是TLR8特异性拮抗剂，IC50值为 0.5 nM。
T11765	KPLH1130	Dehydrogenase; PDK	Metabolism; PI3K/Akt/mTOR signaling
	KPLH1130，一种选择性丙酮酸脱氢酶激酶(PDK)抑制剂，在高脂饮食(HFD)喂养的小鼠中提高了糖耐量。KPLH1130 抑制巨噬细胞极化并减轻了炎症反应。
T11492	GSK2983559 free acid	Others; RIP kinase	Apoptosis; NF-κB; Others
	GSK2983559 free acid 是一种有效的特异性受体相互作用蛋白 2 (RIP2) 抑制剂。 GSK2983559 free acid 在阻断人类炎症性肠病外植体样品和体内的许多促炎细胞因子反应方面表现出优异的活性。
T11598	IAXO-102	TLR	Immunology/Inflammation
	IAXO-102 是一种 TLR4 拮抗剂，可负向调节 TLR4 信号传导，还可以防止实验性腹主动脉瘤的发展。它抑制 MAPK 和 p65 NF-κB 磷酸化和 TLR4 依赖性促炎蛋白的表达。
T2401	Alogliptin Benzoate 苯甲酸阿格列汀,SYR 322,Alogliptin(SYR-322)benzoate	Ferroptosis; Proteasome; DPP-4	Apoptosis; Proteases/Proteasome; Ubiquitination
	Alogliptin Benzoate (SYR 322) 是一种有效且特异性的 DPP-4 抑制剂，IC50值小于 10 nM，其选择性比 DPP-8/9 高 10,000 倍以上，可用于研究 2 型糖尿病。
T1127	Beclometasone dipropionate Beclovent,Beclomethasone dipropionate,二丙酸倍氯米松,丙酸倍氯米松,Beconase,Vancenase	Glucocorticoid Receptor	Endocrinology/Hormones
	Beclometasone dipropionate (Vancenase) 是具有口服活性的糖皮质激素，具有抗炎和免疫抑制作用。它是Betamethasone 的前体药物，Betamethasone 是 LPS 诱导的炎症及 MMP 释放的抑制剂。
T15017	CU-T12-9	TLR	Immunology/Inflammation
	CU-T12-9 是特异性 TLR1/2激动剂，可激活先天免疫系统和适应性免疫系统。它选择性激活 TLR1/2 异二聚体，可通过促进 TLR1 和 TLR2 二聚而激活 NF-κB 信号，引起下游 TNF-α、IL-10 和 iNOS 增加。
T9543	Syk Inhibitor II hydrochloride	Others	Others
	Syk Inhibitor II hydrochloride 信号传导的影响在狼疮中可能很突出。
T70484	AD-35
	AD-35 is a neuroprotectant for treating Alzheimer’s diseases by significantly inhibiting the production and release of proinflammatory cytokines TNF-α and IL-1β.
T70905	TLR9-IN-18
	TLR9-IN-18 is a potent and selective TLR9 antagonist. TLR9-IN-18 suppresses the production of the proinflammatory cytokine IL-6 in a CpG-induced mouse model.
T16570	Pralnacasan VX-740,HMR 3480	Others	Others
	Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan is an effective, non-peptide, and orally active interleukin-1β converting enzyme inhibitor (Ki: 1.4 nM). Pralnacasan has the potential for osteoarthritis and rheumatoid a
T27224	DX-9065A HCl hydrate DX9065,DX 9065,DX9065A,DX 9065A,DX-9065A,DX-9065
	DX-9065A is a factor Xa inhibitor. DX-9065a inhibits proinflammatory events induced by factor Xa and gingipains. DX-9065a is a competitive inhibitor of the Spectrozyme FXa (SpFXa) cleavage by both fXa and prothrombinase with similar K(i) values of approxi
T82467	Endotrophin (Mus musculus)
	Endotrophin (Mus musculus) 为Col6的裂解产物，其上调可能导致纤维化和炎症基因表达增强。
T68620	(R)-DOI hydrochloride
	(R)-DOI hydrochloride is a 5-HT2 receptor agonist, inhibiting TNF-α-mediated proinflammatory signaling cascades and inflammation via 5-HT2A receptor activation and preventing the development of, and inflammation associated with, acute allergic asthma.
T72223	Anti-inflammatory agent 7
	Anti-inflammatory agent 7 通过阻断 LPS 处理的 RAW 264.7 细胞和小鼠的 NF-κB/MAPK 信号通路抑制促炎细胞因子。
T73580	8A8	NO Synthase	Immunology/Inflammation
	8A8 作为促炎因子NO的有效抑制剂，具有4.7 μM的 IC50 值，并显著抑制由 LPS 诱导的 HaCat 细胞增殖。
T74572	RIPK2-IN-2
	RIPK2-IN-2 (example 25) 是RIP2 激酶PROTAC 抑制剂。RIPK2-IN-2 可以阻断 RIP2 依赖的促炎信号，调节 RIP2 激酶在自身炎性疾病中的活性。
T70015	GSK563
	GSK563 is a potent GVIA iPLA2 inhibitor (XI(50) 0.0000021, IC50 1 nM). GSK563 is 22 000 times more active against GVIA iPLA2 than GIVA cPLA2. It was found to reduce β-cell apoptosis induced by proinflammatory cytokines, raising the possibility that it can be beneficial in countering autoimmune diseases, such as type 1 diabetes.
T81668	NLRP3 agonist 1	NOD-like Receptor (NLR)	Immunology/Inflammation
	NLRP3 agonist1 (compound 23)为高效口服活性NLRP3激动剂。该化合物能够激活Caspase-1酶，进而将pro-IL-1β与pro-IL-18等促炎细胞因子裂解为成熟型态。
T79790	ALPK1-IN-3	NF-κB	NF-κB
	ALPK1-IN-3 (T007)为ALPK1抑制剂。在脓毒症引起的急性肾损伤动物模型中，ALPK1-IN-3能够降低肾脏促炎基因的表达并增加动物的存活率。
T36145	12(R)-HETE
	Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid . In mammals, 12(R)-HETE can be produced by 12(R)-LOs and also by CYP450 oxidation. The activity of 12(R)-HETE in mammals is predominantly proinflammatory. 12(R)-HETE exhibits dose-dependent leukocyte chemotaxis at concentrations as low as 100 nM, and lowers intraocular pressure in rabbits.
T61621	IMMH001
	IMMH001, also known as SYL930, is an orally active compound that exhibits potent selectivity as an agonist for the S1P1 receptor, which is the sphingosine-1-phosphate receptor 1. This compound effectively reduces the levels of various chemokines and proinflammatory cytokines, such as IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 finds utility in research focused on rheumatoid arthritis (RA) [1] [2].
T71554	ARN 14494
	ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes.
T60809	MIF-IN-1
	MIF-IN-1 (compound 14) 是巨噬细胞迁移抑制因子(MIF)的抑制剂，pIC50为6.87。巨噬细胞迁移抑制因子 (MIF) 是一种与多种疾病相关的促炎细胞因子，包括神经退行性疾病。
T25976	Ppack HCl Ppack dihydrochloride,Fprmecl, dihydrochloride
	Ppack HCl is a peptide derivative that irreversibly and specifically suppresses thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki: 0.24 nM). It has been utilized as an anticoagulant (100 μM) and to stud
T25977	Ppack trifluoroacetate Ppack trifluoroacetate salt
	Ppack trifluoroacetate is a peptide derivative that irreversibly and specifically suppresses thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki: 0.24 nM). It has been utilized as an anticoagulant (100 μM
T71325	ANA-773
	ANA773 is a Toll-like Receptor 7 (TLR7) agonist prodrug with potential immunostimulating activity. Upon oral administration, ANA773 is metabolized into its active form that binds to and activates TLR7, thereby stimulating dendritic cells (DCs) and enhancing natural killer cell (NK) cytotoxicity. This activation results in the production of proinflammatory cytokines, including interferon alpha, and enhanced antibody-dependent cellular cytotoxicity (ADCC). TLR7 is a member of the TLR family, which...
T80759	XY-52
	XY-52（Compound 32）是ST2抑制剂，AlphaLISA实验中IC50为5.68μM，HEK-Blue实验中为4.59μM。该化合物能提升促炎性T细胞增殖，并在移植物抗宿主病（GVHD）小鼠模型中降低血浆sST2与IFNγ生物标志物水平。
T78822	JT002	NOD-like Receptor (NLR)	Immunology/Inflammation
	JT002为口服活性的NLRP3炎性体抑制剂，能够抑制NLRP3依赖性促炎细胞因子（如IL-1β、IL-1α、IL-18）的生成以及细胞焦亡（pyroptosis），阻断NLRP3炎性体复合物的形成。此外，JT002可有效减少小鼠气道高反应性，并降低气道中中性粒细胞的聚集。
T79304	Semapimod CPSI-2364,CNI-1493 free base
	Semapimod是一种抑制促炎细胞因子产生的化合物，具有抑制TNF-α、IL-1β和IL-6功能。它通过抑制巨噬细胞的p38 MAPK以及一氧化氮的生成发挥作用，并且能够抑制TLR4信号传导（IC50约为0.3 μM）。Semapimod对于治疗各类炎症和自身免疫性疾病显示出潜在效用。
T73527	GK563
	GK563是一种针对Ca2+-independent phospholipase A2(GVIA iPLA2)的选择性抑制剂，具有1 nM的IC50值。相比于GIVA cPLA2，GK563对GVIA iPLA2的抑制活性高出22000倍。它能减少促炎细胞因子诱导的β-cell凋亡，从而增加了其在对抗自身免疫性疾病（例如1型糖尿病）中的潜在应用价值。
TP1891	MMK 1
	Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechanism and enhances production of proi
T82526	Drotrecogin alfa (activated)
	Drotrecogin alfa activated (DrotAA)为重组人活化蛋白C（APC）。该化合物能够抑制由烟雾引起的大鼠肺微血管通透性上升及促炎细胞因子IL-1β水平增加，具有抗凝血与抗炎作用，并促进纤溶过程。Drotrecogin alfa activated主要用于重症脓毒症的实验研究。
T79637	CIAC001
	CIAC001是一种丙酮酸激酶PKM2的抑制剂，它展现出了抗神经炎症活性。这种化合物能够抑制LPS诱导的一氧化氮(NO)产生(IC50=2.5 μM)，并保护BV-2免疫活性细胞。在小鼠模型中，CIAC001减轻了慢性吗啡引起的成瘾和神经炎症症状。
T75090	STING agonist-22
	STINGagonist-22 (CF501) 是一种有效的非核苷酸STING 激动剂。STINGagonist-22 是一种佐剂，通过激活STING 来诱导 I 型干扰素 (IFN-I) 反应和促炎细胞因子的产生。STINGagonist-22 可用作增强原始蛋白疫苗的佐剂，产生有效、广泛和长期的免疫保护。STINGagonist-22 可用于 SARS-CoV-2 变异和 sarbecovirus 疾病研究。
T69288	CEP-7055
	CEP-18770 is an orally bioavailable synthetic P2 threonine boronic acid inhibitor of the chymotrypsin-like activity of the proteasome, with potential antineoplastic activity. Proteasome inhibitor CEP 18770 represses the proteasomal degradation of a variety of proteins, including inhibitory kappaBalpha (IkappaBalpha), resulting in the cytoplasmic sequestration of the transcription factor NF-kappaB; inhibition of NF-kappaB nuclear translocation and transcriptional up-regulation of a variety of cel...
T75812	MMK1 TFA
	MMK1 TFA 是一种有效的选择性人甲酰肽受体样 1 (FPRL-1/FPR2) 激动剂，对 FPRL-1 和 FPR1 的 EC50值分别为 <2 nM 和 >10000 nM。MMK1 TFA 是一种有效的趋化剂和钙动员 (calcium-mobilizing) 激动剂。MMK1 TFA 可有效激活吞噬性白细胞，并可增强人单核细胞对百日咳毒素敏感的促炎细胞因子 IL-1b 和IL-6的产生。MMK1 TFA 发挥抗焦虑样活性。
T78018	Plasminogen
	Plasminogen是一种可由尿激酶血浆蛋白原激活剂(uPA)或组织血浆蛋白原激活剂(tPA)裂解激活的分泌性蛋白，生成血浆蛋白，该酶可以广泛裂解纤维蛋白及其他ECM成分。作为促炎调节剂，Plasminogen能促进急性及糖尿病相关伤口愈合。该蛋白在伤口愈合、炎症和低纤溶酶原血症的研究中有重要应用。
T68321	AS1940477
	AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent c...
T23028	MRT67307 HCl (1190378-57-4 free base) MRT67307 HCl	Others	Others
	MRT67307 is an inhibitor for TBK1, IKKε , MARK1-4 and NUAK1 with IC50 value of 19, 160, 27-52 and 230nM , respectively [1]. It is an inhibitor for ULK1and ULK2 with IC50 value of 45 and 38nM, respectively [2]. Also, it is a salt inducible kinase (SIK) inhibitor with IC50 value of 250, 67 and 430nM for SIK1, SIK2 and SIK3, respectively.<br />SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and oth...
T36486	Benpyrine
	Benpyrine is a highly specific and orally active TNF-α inhibitor with a KD value of 82.1 μM. Benpyrine tightly binds to TNF-α and blocks its interaction with TNFR1, with an IC50 value of 0.109 μM. Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1]. Benpyrine (5-20 μM; 14 hours; RAW264.7 cells) pretreatment results in a dose-dependent decrease in the phosphorylation of IκBα in RAW264.7 cells (stimulated with 10 ng/mL TNF-α or 1 μg/mL LPS). Benpyrine abo...
T36629	Givinostat
	Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF3056. At 25, 50, and 100 nM, Givinostat reduced IL-1β secretion more than 70%. Givinostat (ITF-2357) suppresses the production of IL-6 in PBMCs stimulated with TLR agonists as well as the combination of IL-12 plus IL-18. IL-6 secretion decreases to 50% at 50 nM Givinostat, but at 1...
T35451	β-Defensin-2 (human) (trifluoroacetate salt)
	β-Defensin-2 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1It inhibits the growth of periodontopathogenic and cariogenic bacteria, includingP. gingivalisandS. salivarius.2β-Defensin-2 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3It also stimulates calcium mobilization, migration, and proliferation of keratinocytes whe...
T36996	MSA-2 dimer
	MSA-2 dimer is a selective, orally active non-nucleotide STING agonist (Kd=145 μM) with long-term antitumor and immunogenic activity. MSA-2 dimer is bound to STING as a non-covalent dimer exhibiting higher permeability than cyclic dinucleotide[1]. MSA-2 dimer (60 mg/kg; p.o.; 50 days) inhibits tumor growth and prolongs overall survival[1]. MSA-2 dimer (40 mg/kg; s.c.; 25 days) induces complete tumor regression[1].MSA-2 dimer (60 mg/kg; p.o.; 4 hours) increases proinflammatory cytokine (IFN-β) le...
T37861	Talabostat
	Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,...
T35881	Resolvin E2
	Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.2,3RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A .3Hepatic RvE2 levels are increased in m...

化合物

Cat.No: T28628

Synonym: RVX297

Target: Epigenetic Reader Domain

Cat.No: T6716

Synonym: Diovan,缬沙坦,Tareg,CGP 48933

Target: RAAS

Cat.No: T2036

Synonym: GTPL5846

Target: GPR

Hydrocortisone hemisuccinate

Cat.No: T4602

Synonym: Hydrocortisone 21-he,氢化可的松琥珀酸酯,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate

Target: Glucocorticoid Receptor, Others, Interleukin

Cat.No: T7317

Target: TLR

Cat.No: T11765

Target: Dehydrogenase, PDK

GSK2983559 free acid

Cat.No: T11492

Target: Others, RIP kinase

Cat.No: T11598

Target: TLR

Alogliptin Benzoate

Cat.No: T2401

Synonym: 苯甲酸阿格列汀,SYR 322,Alogliptin(SYR-322)benzoate

Target: Ferroptosis, Proteasome, DPP-4

Beclometasone dipropionate

Cat.No: T1127

Synonym: Beclovent,Beclomethasone dipropionate,二丙酸倍氯米松,丙酸倍氯米松,Beconase,Vancenase

Target: Glucocorticoid Receptor

Cat.No: T15017

Target: TLR

Syk Inhibitor II hydrochloride

Cat.No: T9543

Target: Others

Cat.No: T70484

Cat.No: T70905

Cat.No: T16570

Synonym: VX-740,HMR 3480

Target: Others

DX-9065A HCl hydrate

Cat.No: T27224

Synonym: DX9065,DX 9065,DX9065A,DX 9065A,DX-9065A,DX-9065

Endotrophin (Mus musculus)

Cat.No: T82467

(R)-DOI hydrochloride

Cat.No: T68620

Anti-inflammatory agent 7

Cat.No: T72223

Cat.No: T73580

Target: NO Synthase

Cat.No: T74572

Cat.No: T70015

NLRP3 agonist 1

Cat.No: T81668

Target: NOD-like Receptor (NLR)

Cat.No: T79790

Target: NF-κB

Cat.No: T36145

Cat.No: T61621

Cat.No: T71554

Cat.No: T60809

Cat.No: T25976

Synonym: Ppack dihydrochloride,Fprmecl, dihydrochloride

Ppack trifluoroacetate

Cat.No: T25977

Synonym: Ppack trifluoroacetate salt

Cat.No: T71325

Cat.No: T80759

Cat.No: T78822

Target: NOD-like Receptor (NLR)

Cat.No: T79304

Synonym: CPSI-2364,CNI-1493 free base

Cat.No: T73527

Cat.No: TP1891

Drotrecogin alfa (activated)

Cat.No: T82526

Cat.No: T79637

STING agonist-22

Cat.No: T75090

Cat.No: T69288

Cat.No: T75812

Cat.No: T78018

Cat.No: T68321

MRT67307 HCl (1190378-57-4 free base)

Cat.No: T23028

Synonym: MRT67307 HCl

Target: Others

Cat.No: T36486

Cat.No: T36629

β-Defensin-2 (human) (trifluoroacetate salt)

Cat.No: T35451

Cat.No: T36996

Cat.No: T37861

Cat.No: T35881

Cat. No.	Product Name	Target	Signaling Pathways
TN6730	Epoxyazadiradione	NF-κB	NF-κB
	Epoxyazadiradione 是从印楝果实中得到的柠檬苦素。它能够可逆的、非竞争性的抑制人类、约氏疟原虫、疟原虫的互变异构酶活性。它具有抗疟原虫和人类 MIF 诱导的促炎反应的潜力。
TQ0218	Deoxyandrographolide 去氧穿心莲内酯,14-deoxyandrographolide	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Deoxyandrographolide (14-deoxyandrographolide) 抑制 LPS 诱导的 iNOS mRNA 水平升高以及促炎症介质 TNF-α 和 IL-6 的产生。它增强 NGF 诱导的神经突起生长。
T7926	Carmoisine Azo Rubine,Chromotrope FB,偶氮玉红,铬变素FB	Others	Others
	Carmoisine (Azo Rubine) 是一种可用作食品添加剂的偶氮染料。
TQ0054	Purpureaside C	Others	Others
	Purpureaside C 是一种酚类糖苷类，具有显着的促炎、免疫调节和抗菌作用。
T10689	Cauloside D	Others	Others
	Cauloside D 是一种分离自 Caulophyllum robustumMax 中的三萜苷类化合物。它能够阻碍 iNOS 和促炎细胞因子的表达，具有抗炎活性。
T5660	Menthone	IL Receptor; TNF; NF-κB; Parasite	Apoptosis; Immunology/Inflammation; Microbiology/Virology; NF-κB
	Menthone 是一种从植物和薄荷油中提取的单萜，是精油的主要挥发性成分，具有抗炎和抗氧化特性。
T3887	Rosarin	Others	Others
	Rosarin 是从玫瑰红景天中分离出来的肉桂醇糖苷。它抑制小鼠肾脏和大脑前额皮层中促炎因子 iNOS，IL-1β 和 TNF-α 的表达。它具有抗炎和神经保护作用。
TJS0315	4-Methyldaphnetin 7,8-Dihydroxy-4-methylcoumarin,4-甲基瑞香素,DHMC,7,8-二羟基-4-甲基香豆素	Apoptosis; Lipoxygenase	Apoptosis; Metabolism
	4-Methyldaphnetin (DHMC) 是一种合成 4-甲基香豆素衍生物的前体。它对几种肿瘤细胞株具有选择性的抗增殖和诱导凋亡的作用。它能够清除自由基，显著抑制膜脂过氧化。
T2S2173	(E)-Naringenin chalcone Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮	Others	Others
	Naringenin chalcone (Isosalipurpol) 是一种黄酮醇生物合成的中间体，在查耳酮异构酶的作用下，自发代谢成柚皮素。它具有抗炎和抗过敏活性。
TN1448	(-)-Bornyl acetate L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯	p38 MAPK; NF-κB; JNK; Antifungal	MAPK; Microbiology/Virology; NF-κB
	(-)-Bornyl acetate (L-(-)-Bornyl acetate) 是存在于牛膝草油中的一种具有抗真菌活性的 (+)-Bornyl acetate 低活性异构体。
T3753	Sinapinic Acid Sinapic acid,芥子酸,Synapoic acid	Apoptosis; RAAS; Reactive Oxygen Species; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB
	Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类，是HDAC 抑制剂，对ACE-I 的活性也有抑制作用。它有抗肿瘤活性，诱导肿瘤细胞凋亡，具有抗氧化、抗糖尿病的作用。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。
T3795	Corilagin	Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology
	Corilagin 是一种鞣酸，有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长，MIC 为 25 μg/mL。它有抗肿瘤活性，可用于肝癌和卵巢癌。
T4S2326	Cornuside 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside	ERK; p38 MAPK; NF-κB; JNK	MAPK; NF-κB
	Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷，可用于炎症疾病的研究和促进血液循环。它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应，用于炎性过敏性疾病中的潜能。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶，具有抗肿瘤特性。
TN6442	Esculentoside C
	Esculentoside C exerts proinflammatory effects synergistically, it can induce inflammatory stimulation.
T14877	Cauloside C	Others	Others
	Cauloside C, a triterpene glycoside isolated from Caulophyllum robustum Max, exerts anti-inflammatory effects through the inhibition of expression of iNOS and proinflammatory cytokines.
TN4093	Galeopsin	TNF	Apoptosis
	Galeopsin shows potential anti-inflammatory activity by inhibiting proinflammatory cytokine TNF-α, it has anti-proliferative effect on several cancer cell lines.
TN1504	Citreorosein 羟基大黄素	cAMP; NF-κB; PI3K	GPCR/G Protein; NF-κB; PI3K/Akt/mTOR signaling
	Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation and subsequent inhibition of transcription factor NF-κB activation.
T78497	λ-Carrageenan
	λ-Carrageenan是广泛应用于基础研究的海藻多糖，常用作促炎剂，并具有有效的抗肿瘤活性。
T79970	Taxamairin B
	Taxamairin B是有效的抗炎化合物，能显著抑制LPS诱导的RAW264.7细胞中促炎因子(TNF-α, IL-1β和IL-6)表达及NO、ROS生成，并对LPS引起的急性肺损伤模型小鼠具有保护效果。
TN6524	Irilone
	Irilone has immunomodulatory, and α-amylase inhibitory activities, it exhibits the selective inhibition toward CYP3 A4 rather than other major human CYPs. Irilone exhibited prominent antioxidant activities with the IC50 value of 10.46μM. Irilone potentiat

天然产物

Epoxyazadiradione

Cat.No: TN6730

Target: NF-κB

Deoxyandrographolide

Cat.No: TQ0218

Synonym: 去氧穿心莲内酯,14-deoxyandrographolide

Target: IL Receptor, TNF

Cat.No: T7926

Synonym: Azo Rubine,Chromotrope FB,偶氮玉红,铬变素FB

Target: Others

Cat.No: TQ0054

Target: Others

Cat.No: T10689

Target: Others

Cat.No: T5660

Target: IL Receptor, TNF, NF-κB, Parasite

Cat.No: T3887

Target: Others

4-Methyldaphnetin

Cat.No: TJS0315

Synonym: 7,8-Dihydroxy-4-methylcoumarin,4-甲基瑞香素,DHMC,7,8-二羟基-4-甲基香豆素

Target: Apoptosis, Lipoxygenase

(E)-Naringenin chalcone

Cat.No: T2S2173

Synonym: Isosalipurpol,柚皮苷查尔酮,Chalconaringenin,trans-2'4'6'4-tetrahydroxychalcone,柚皮素查耳酮

Target: Others

(-)-Bornyl acetate

Cat.No: TN1448

Synonym: L-(-)-Bornyl acetate,左旋乙酸冰片酯,Bornyl acetate,(-)-乙酸龙脑酯

Target: p38 MAPK, NF-κB, JNK, Antifungal

Cat.No: T3753

Synonym: Sinapic acid,芥子酸,Synapoic acid

Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

Cat.No: T3795

Target: Apoptosis, TLR, Reverse Transcriptase, Antibacterial, Autophagy

Cat.No: T4S2326

Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside

Target: ERK, p38 MAPK, NF-κB, JNK

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Esculentoside C

Cat.No: TN6442

Cat.No: T14877

Target: Others

Cat.No: TN4093

Target: TNF

Cat.No: TN1504

Synonym: 羟基大黄素

Target: cAMP, NF-κB, PI3K

Cat.No: T78497

Cat.No: T79970

Cat.No: TN6524

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