首页工具

登录

搜索结果

Search Results for " mesenchymal "

49

抑制剂 & 化合物

19

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T9151	Teplinovivint	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Teplinovivint 是 wnt/β-catenin 信号通路抑制剂。它具有抗炎作用，对用于肌腱病具有潜在的研究价值。
T1748	Kartogenin KGN	TGF-beta/Smad	Stem Cells
	Kartogenin (KGN) 是一种人间充质干细胞分化为软骨细胞的诱导剂(EC50:100 nM)。它能够结合纤维蛋白 A，破坏其与转录因子核心结合因子 β 亚基 (CBFβ) 的相互作用，并通过调节 CBFβ-RUNX1 转录程序，诱导软骨形成，可用于研究骨关节炎。
T22814	GSA-10	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	GSA-10是新型的喹啉甲酰胺衍生物，有效激动平滑受体剂，EC50为 1.2 μM。它作用于Smo，促进多能间充质干细胞分化为成骨细胞。它介导 Hedgehog 信号传导，这可能对癌症疾病的再生医学具有研究意义。
T21981	Phthalazinone pyrazole	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Phthalazinone pyrazole 是强效、选择性和口服生物可利用的 Aurora-A 激酶抑制剂，IC50值为 0.031 μM。它抑制人胚胎干细胞向肝细胞样细胞分化过程中的上皮间质转化。它还可阻止有丝分裂并随后通过增殖细胞的凋亡抑制肿瘤生长。
T13410	ZLDI-8	Apoptosis; Phosphatase; Gamma-secretase; Immunology/Inflammation related	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; Proteases/Proteasome; Stem Cells
	ZLDI-8 是 Notch 激活/裂解酶 ADAM-17 的抑制剂，可抑制 Notch 蛋白裂解，并降低促存活/抗凋亡和上皮-间质转化相关蛋白的表达。它还是竞争性不可逆酪氨酸磷酸酶抑制剂，以IC50为 5.32 μM 抑制 MHCC97-H 细胞的生长。
T11847L	Liarozole R75251 dihydrochloride,利阿唑	P450; Retinoid Receptor	Metabolism
	Liarozole (R75251 dihydrochloride) 是一种咪唑衍生物，是一种具有口服活性的维甲酸 (RA) 代谢阻断剂(RAMBA)，具有抗肿瘤作用。它能够抑制维甲酸依赖的细胞色素P450(CYP26) 4- 羟基化 (IC50=7 μM)，导致组织维甲酸水平增加。
T0459	Sulindac Arthrocine,MK-231,舒林酸,Clinoril,Sulindac sulfoxide	COX; Autophagy	Autophagy; Immunology/Inflammation; Neuroscience
	Sulindac (Sulindac sulfoxide) 是一种非甾体类抗炎剂，可抑制COX-2的活性，也可抑制 COX-2 的过表达。它是一种亚磺酰基茚衍生物前药，具有潜在的抗肿瘤活性。
T1725	Y-27632 dihydrochloride 反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐,Y-27632 2HCl	ROCK; Apoptosis	Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Y-27632 dihydrochloride (Y-27632 2HCl) 是一种 ROCK-I 和 ROCK-II 抑制剂，具有口服有效性、ATP 竞争性。Y-27632 dihydrochloride 还抑制分离诱导的小鼠前列腺干或祖细胞凋亡。
T8400	Pamidronic acid	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Pamidronic acid 可用于各种骨吸收类疾病的研究。
T23446	TCS 2210	Others	Others
	TCS 2210是间充质干细胞中神经元分化的诱导剂，并增加神经元标志物β-III 管蛋白的表达和神经元特异性烯醇酶的表达。
T28164	Nexopamil LU49938,LU 49938,LU-49938	Calcium Channel; 5-HT Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nexopamil (LU-49938) 是一种钙通道拮抗剂，是一种5-羟色胺2A 受体拮抗剂。Nexopamil 可抑制5-HT 诱导的间质细胞收缩和增殖。
T9601	Tepotinib hydrochloride(1 : x)	c-Met/HGFR; P-gp; ABC	Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors
	Tepotinib hydrochloride(1 : x) 是一种口服生物可利用的间充质-上皮转化 (MET) TKI，主要针对具有 METex14 跳跃突变的特定 NSCLC 患者开发。
T4252	ML327	c-Myc; Autophagy	Autophagy; Cell Cycle/Checkpoint
	ML327 是 MYC 的阻断剂，还可抑制 E-钙粘蛋白转录和逆转上皮间质转化。
T38752	EW-7195	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	EW-7195 是一种具有选择性和高效性的 ALK5 (TGFβR1) 抑制剂，IC50 值为 4.83 nM。EW-7195 对 ALK5 的亲和力是 p38α 的 300 多倍。EW-7195 对 TGF-β1 诱导的 Smad 信号转导、上皮间质转化 (EMT) 和乳腺癌向肺转移有抑制作用。
T73300	AXL-IN-13	FLT; TAM Receptor; PDGFR; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	AXL-IN-13 是一种有效且具有口服活性的 AXL 抑制剂，其IC50值为 1.6 nM，Kd 值为0.26 nM。AXL-IN-13 具有抗癌活性，可逆转 TGF-β1 诱导的上皮间质转化 (EMT)，并抑制癌细胞迁移和侵袭。
T63049	CHD1Li 6.11	Others	Others
	CHD1Li 6.11 是一种致癌 CHD1L 的有效抑制剂，能够作用于 cat-CHD1L 重组蛋白 (IC50: 3.3 μM)。CHD1Li 6.11 是一种口服具有活力的抗肿瘤剂，明显减少由分离的准间充质细胞 (M 表型) 产生的 CRC 异种移植物的肿瘤体积，这些细胞具有增强的致瘤特性。
T9657	FiVe1	Others	Others
	FiVe1是一种波形蛋白结合小分子，在中期促进波形蛋白解体和磷酸化，导致有丝分裂灾难，多核化和癌细胞干性丧失；选择性地和不可逆地抑制间充质转化的乳腺癌细胞（FOXC2-HMLER 细胞IC50=234nM）和不同组织学亚型的软组织肉瘤的生长。
T11793	KY-05009	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	KY-05009 是 ATP 竞争性的、有效的 TNIK 抑制剂，Ki 为 100 nM。KY-05009抑制人肺腺癌细胞中 TGF-β1 诱导的上皮-间质转化。KY-05009 还抑制TNIK 的蛋白表达和Wnt 靶基因的转录活性，并诱导癌细胞凋亡，显示抗癌活性。
T17044	Tesaglitazar	PPAR	DNA Damage/DNA Repair; Metabolism
	Tesaglitazar 是一种有效且具有选择性的过氧化物 PPAR α / γ受体双重激动剂，对 PPARγ的亲和力比 PPARα更有效，对大鼠PPARα和人PPARα的EC50分别为13.4 μM 和3.6 μM,对大鼠PPARγ和人类 PPARγ的EC50都是0.2 μM。Tesaglitazar 诱导大鼠皮下组织间质间充质细胞DNA 合成和纤维肉瘤形成。
T77701	FL118 FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin	Survivin	Apoptosis
	FL118是一种新型存活素抑制剂，可抑制癌症干细胞样特性。FL118 是一种新型喜树碱类似物，具有抗癌活性，通过 Wnt/β-catenin 信号通路抑制上皮-间充质转化，从而抑制人乳腺癌细胞的迁移和侵袭。
T77697	BML-278 BML278,BML 278	Sirtuin; Histone Methyltransferase	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BML-278 是一种 SIRT1 激活剂，EC150 值为 1 μM。BML-278 增加父本和母本原核中的 H3K9 甲基化并抑制 H3K9 乙酰化，可用于改善早期胚胎发育。BML-278 促使原代人间充质细胞的细胞周期停止在 G1/S 期，可用于延缓衰老。BML-278 减少 U937 细胞中的微管蛋白乙酰化，增加小鼠 C2C12 成肌细胞的线粒体密度。
T36696	DMBA
	7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzymes, including the cytochrome P450 (CYP450) isoform CYP1B1, as well as microsomal epoxide hydrolase (mEH), producing a variety of reactive metabolites that form DNA adductsin vivo, and it has been commonly used to induce tumor formation in various rodent models.2,3,1DMBA increase...
T34627	SFO Safrole epoxide,Safrole oxide
	SFO is an endothelial-to-mesenchymal transition (EndoMT) inducer.
T11187	EMT inhibitor-2	Others	Others
	EMT inhibitor-2 inhibits CYP3A4 testosteron and CYP2C9 with IC50s of 49.72 and 5.54 μM, respectively. EMT inhibitor-2 inhibits epithelial-mesenchymal transition (EMT) induced by substances such as IL-1β and TGF-β released from the immunocytes.
T79789	DT-6	TGF-beta/Smad	Stem Cells
	DT-6为一有效TGF-β1抑制剂，能够抑制M2巨噬细胞诱导的上皮至间质转化(Epithelial-Mesenchymal Transition, EMT)及癌细胞侵袭性迁移，可用于癌症相关疾病研究。
TP2437	Sarasinoside A1 Sarasinoside-A1
	Sarasinoside A1 is a triterpenoid saponin that reverses mesenchymal tumor transformation.
T31124	CW 008 CW-008,CW008
	CW 008 is an activator of the cAMP/PKA/CREB pathway. It promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells in vitro and increases bone mass and bone volume density in ovariectomized mice.
T76994	Sotevtamab
	Sotevtamab (16B5) 是一种抗clusterin 单克隆抗体 (mAb)。Sotevtamab 是上皮间充质转化的抑制剂。Sotevtamab 可用于癌症研究。
T72880	PI3K/AKT-IN-2
	PI3K/AKT-IN-2 是一种 PI3K 和 AKT 抑制剂。PI3K/AKT-IN-2 阻断上皮-间质转化 (EMT)，诱导细胞凋亡 (apoptosis)。PI3K/AKT-IN-2 抑制微管蛋白 (tubulin) 的聚合。
T83075	Anticancer agent 94
	Anticanceragent 94, 一种4-羟基香豆素衍生物，能抑制肺癌细胞的侵袭和迁移，其机制为调节(EMT)效应子表达。
T83076	Anticancer agent 93
	Anticanceragent 93, 一种4-羟基香豆素衍生物，能够抑制肺癌细胞的侵袭与迁移，其机制为调节上皮间质转化（EMT）效应子的表达。
T60792	NMDA receptor antagonist-3
	NMDA receptor antagonist-3 是NMDA 受体的拮抗剂。NMDA receptor antagonist-3 在 SH-SY5Y 和人脂肪间充质干细胞中具有显著的回收率（40.0 %，100 μM）和安全的毒理学特性。
T61417	PPARγ agonist 7
	PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It specifically stimulates adiponectin production in human bone marrow mesenchymal stem cells (hBM-MSCs), making it an innovative full agonist of PPARγ with an EC 50 value of 4.34 μM [1].
T39531	RAD16-I hydrochloride RAD16-I hydrochloride
	RAD16-I hydrochloride is a self-assembling peptide with nanofibrous morphology that provides an optimal microenvironment for the proliferation and differentiation of human mesenchymal stem cells (hMSC) into chondrocytes. This peptide, known as RAD16-I, has been extensively studied and serves as a model to assess the amyloid-like staining properties of self-assembling peptide nanofibers (SAPNFs).
TP1152	Fibronectin Adhesion-promoting Peptide TFA Heparin Binding Peptide TFA
	Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into lar
T82673	CPF-7 Caerulein precursor fragment
	CPF-7（Caerulein precursor fragment）是一种促进胰岛素释放的肽，可以通过增加PANC-1导管细胞中Snai1表达来引导上皮-间质转换（EMT），并且CPF-7还能通过提高Ngn3表达以诱导外分泌细胞可塑性。此外，CPF-7适用于2型糖尿病的相关研究。
T73547	CPUL1
	CPUL1 是一种TrxR 抑制剂，对 A549 细胞显示出增殖抑制和抗转移活性。CPUL1 通过抑制TrxR1酶活性来诱导 ROS 介导的ERK/JNK 信号传导从而影响上皮-间质转化 (EMT)。CPUL1 与α-Lipoic Acid 或Dithiodipropionic acid 联合使用效果更好。
T71884	ß-Carboline-1-carboxylic acid
	β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 µg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells. β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 µg/ml, respectively) but not Hep...
T61852	hCAIX-IN-8
	hCAIX-IN-8 (compound 7i) is a highly potent and selective inhibitor of hCAIX, demonstrating potent inhibitory activity against CAIX with an IC50 value of 0.024 μM. It also exhibits inhibitory activity against CAII and CAVA with IC50 values of 1.99 μM and 1.10 μM, respectively. Furthermore, hCAIX-IN-8 exhibits anti-proliferative effects and low toxicity. It effectively reduces the occurrence of epithelial-to-mesenchymal transitions and promotes apoptosis. Additionally, hCAIX-IN-8 effectively inhi...
T62814	Antitumor agent-77
	Antitumor agent-77 对癌细胞的生长和迁移具有抑制作用，具有抗癌作用。Antitumor agent-77 能够抑制 GPx-4 和提高 COX2 引发铁下垂。Antitumor agent-77 可以激活肿瘤细胞固有凋亡通路 (Bax-Bcl-2-caspase-3)，阻碍肿瘤细胞上皮间质转化 (EMT) 过程。
T73035	STAT3-IN-15
	STAT3-IN-15是一款有效、具口服活性的STAT3抑制剂，用于对抗特发性肺纤维化（IPF）。该化合物阻止STAT3磷酸化，同时抑制TGF-β1引起的上皮细胞迁移及变形，并防止上皮间质转化（EMT）。
T36460	CAY10736 CAY10736
	CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a ...
T62822	CT1-3
	CT1-3 是一种有效的抗癌剂。CT1-3 能够调控 JNK/Bcl-2/Bax/XIAP 通路，进而诱导线粒体介导的细胞凋亡 (apoptosis)。CT1-3 可以调控 E-cadherin/Snail 轴抑制人癌细胞 (HCCs) 的上皮间充质转化 (EMT) 电位，并抑制肿瘤发生。CT1-3 在小鼠模型中具有抗肿瘤作用，且没有表现出明显的肝、肾毒性。
T63768	Antitumor agent-78
	Antitumor agent-78 能够抑制 GPx-4 和升高 COX2 ，进而导致铁下垂 (ferroptosis)。Antitumor agent-78 可以激活肿瘤细胞固有凋亡通路 (Bax-Bcl-2-caspase-3)，抑制肿瘤细胞上皮间质转化 (EMT) 过程。Antitumor agent-78 表现出抗肿瘤效果，并能够抑制癌细胞的生长和迁移。
T61746	Anticancer agent 82
	Anticancer agent 82 是 FiVe1 衍生物，是一种口服有效的选择性抗癌剂。FiVe1 能够结合 III 型中间丝蛋白vimentin(VIM)，诱导 Ser56 过度磷酸化，导致有丝分裂的选择性中断和转化表达 VIM 的间充质癌细胞的多核化。Anticancer agent 82 比 FiVe1 表现出更好的口服利用度和药代动力学特征。
T36497	CAY10735 CAY10735
	CAY10735 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mesenchymal transition (EMT) in A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 3.04 and 1.24 μM, respectively) and increases production of reactive oxygen species (ROS) in these cells ...
T61585	Sulindac sodium
	Sulindac (sodium) (MK-231) 是一种非甾体抗炎剂，具有口服活性。Sulindac (sodium) 用于减轻疼痛，肿胀和关节僵硬的关节炎。Sulindac 还用于脊柱关节炎、痛风性关节炎的研究。Sulindac (sodium) 作为一种免疫调节剂，可通过阻断 NF-κB 信号通路下调 PD-L1，调节 pMMR CRC 对抗 PD-L1 免疫治疗的应答，抑制结直肠癌 CRC 的发生发展。 Sulindac 还可通过下调 SIRT1 抑制 TGF-β1-诱导的 EMT，抑制肺癌细胞的迁移和侵袭。
T83848	VnP-16 TFA
	VnP-16是一种合成肽段，对应vitronectin的氨基酸270-281，vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时，能促进人类成骨细胞的附着和扩散，此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内，VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。
T35513	13C15-Nivalenol 13C15-Nivalenol
	13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol by GC- or LC-MS. Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It is lethal to mice (LD50= 6.9 mg/kg).2Nivalenol (5, 10, and 15 mg/kg) also induces thymic, splenic, and Peyer's patch cell apoptosis in mice.3 1.Yang, Z., Concannon, J., Ng, K.S., et al.Tetrandrine identified in a small molecule screen to activate mesenchymal stem cells for enhanced immunomodulationSci. Rep.63026...

化合物

Cat.No: T9151

Target: Wnt/beta-catenin

Cat.No: T1748

Synonym: KGN

Target: TGF-beta/Smad

Cat.No: T22814

Target: Hedgehog/Smoothened

Phthalazinone pyrazole

Cat.No: T21981

Target: Aurora Kinase

Cat.No: T13410

Target: Apoptosis, Phosphatase, Gamma-secretase, Immunology/Inflammation related

Cat.No: T11847L

Synonym: R75251 dihydrochloride,利阿唑

Target: P450, Retinoid Receptor

Cat.No: T0459

Synonym: Arthrocine,MK-231,舒林酸,Clinoril,Sulindac sulfoxide

Target: COX, Autophagy

Y-27632 dihydrochloride

Cat.No: T1725

Synonym: 反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐,Y-27632 2HCl

Target: ROCK, Apoptosis

Pamidronic acid

Cat.No: T8400

Target: Wnt/beta-catenin

Cat.No: T23446

Target: Others

Cat.No: T28164

Synonym: LU49938,LU 49938,LU-49938

Target: Calcium Channel, 5-HT Receptor

Tepotinib hydrochloride(1 : x)

Cat.No: T9601

Target: c-Met/HGFR, P-gp, ABC

Cat.No: T4252

Target: c-Myc, Autophagy

Cat.No: T38752

Target: ALK, TGF-beta/Smad

Cat.No: T73300

Target: FLT, TAM Receptor, PDGFR, TGF-beta/Smad

Cat.No: T63049

Target: Others

Cat.No: T9657

Target: Others

Cat.No: T11793

Target: Wnt/beta-catenin

Cat.No: T17044

Target: PPAR

Cat.No: T77701

Synonym: FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin

Target: Survivin

Cat.No: T77697

Synonym: BML278,BML 278

Target: Sirtuin, Histone Methyltransferase

Cat.No: T36696

Cat.No: T34627

Synonym: Safrole epoxide,Safrole oxide

EMT inhibitor-2

Cat.No: T11187

Target: Others

Cat.No: T79789

Target: TGF-beta/Smad

Sarasinoside A1

Cat.No: TP2437

Synonym: Sarasinoside-A1

Cat.No: T31124

Synonym: CW-008,CW008

Cat.No: T76994

Cat.No: T72880

Anticancer agent 94

Cat.No: T83075

Anticancer agent 93

Cat.No: T83076

NMDA receptor antagonist-3

Cat.No: T60792

PPARγ agonist 7

Cat.No: T61417

RAD16-I hydrochloride

Cat.No: T39531

Synonym: RAD16-I hydrochloride

Fibronectin Adhesion-promoting Peptide TFA

Cat.No: TP1152

Synonym: Heparin Binding Peptide TFA

Cat.No: T82673

Synonym: Caerulein precursor fragment

Cat.No: T73547

ß-Carboline-1-carboxylic acid

Cat.No: T71884

Cat.No: T61852

Antitumor agent-77

Cat.No: T62814

Cat.No: T73035

Cat.No: T36460

Synonym: CAY10736

Cat.No: T62822

Antitumor agent-78

Cat.No: T63768

Anticancer agent 82

Cat.No: T61746

Cat.No: T36497

Synonym: CAY10735

Sulindac sodium

Cat.No: T61585

Cat.No: T83848

13C15-Nivalenol

Cat.No: T35513

Synonym: 13C15-Nivalenol

Cat. No.	Product Name	Target	Signaling Pathways
T3862	Irigenin	NF-κB; Integrin	Cytoskeletal Signaling; NF-κB
	Irigenin 可通过特异性和选择性地阻断 Extra Domain A 域的 C-C 环上α9β1和α4β1整合素结合位点，介导其抗转移作用。可通过增强胃癌细胞中促凋亡分子的表达来敏化 TRAIL 诱导的凋亡，具有抗癌作用。
T3S2072	3-Butylidenephthalide Butylidene phthalide,n-Butylidenephthalide,丁烯基苯酞,丁烯基苯酞；丁烯基酞内酯	Parasite; Glucosidase	Metabolism; Microbiology/Virology
	3-Butylidenephthalide (Butylidene phthalide) 是从 Ligusticum chuanxiongHort 鉴定出的一种邻苯二甲酸酐衍生物，有杀虫活性。
T0518	Methacycline hydrochloride Rondomycin,盐酸甲烯土霉素,盐酸美他环素,Methacycline HCl	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Methacycline hydrochloride (Rondomycin) 是四环素抗生素，可抑制细菌蛋白质的合成。它是上皮-间质转化 (EMT) 抑制剂。它在体外可阻断 EMT，体内抑制纤维发生，不会直接影响 TGF-β1 Smad 信号传导。它是抗菌剂，有潜力研究肺纤维化。
TN7036	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) 是一种从玛卡中分离得到的玛卡酰胺。它能够激活典型的Wnt/β‐catenin 信号通路，诱导间充质干细胞成骨分化和随后的骨形成，可用于研究骨质疏松症。
TN1198	19-Hydroxybufalin	Others	Others
	19-Hydroxybufalin 是蟾二烯羟酸内酯，能够阻碍上皮间质转化，抑制 PC3 细胞的迁移和侵袭。
TN2081	Maohuoside A	MAPK	MAPK
	Maohuoside A 是从 E. koreanum 中分离出的单一化合物，具有促进成骨作用。它能够利用 MAPK 信号通路骨及形态发生蛋白 (BMP) ，促进骨髓间充质干细胞的成骨作用。
T2S0690	Ecliptasaponin A 早莲苷 A,旱莲苷A,Echinocystic acid-3-o-glucoside	Others	Others
	Ecliptasaponin A (Echinocystic acid-3-o-glucoside) 是一种墨旱莲 (Eclipta prostrate) 中分离得到的五环三萜皂苷。其中墨旱莲是一种具有多效作用的滋补草药，如抗炎、保肝、抗氧化和免疫调节。
T4S1383	Escin IA Aescin IA,Escin IA;Aescin IA,Escin IA	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Escin IA (Escin IA;Aescin IA);Aescin IA 是从马蹄中七叶树分离出的一种三萜皂苷，抑制HIV-1蛋白酶，IC50值为 35 μM。它具有抗 TNBC 转移活性，其作用机制涉及通过下调 LOXL2 表达抑制上皮-间质转化过程。
T3330	trans-Trimethoxyresveratrol trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,白藜芦醇三甲醚,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	trans-Trimethoxyresveratrol (MR-3) 是一种 Resveratrol(RSV) 的衍生物，与Resveratrol(RSV)相比，它可能是一个更有效的抗炎、抗血管新生的化合物。
T7982	3,6-Dihydroxyflavone	Others	Others
	3,6-Dihydroxyflavone 是一种抗癌剂。它能够提高细胞内氧化应激和脂质过氧化。它是能够根据剂量和时间依赖性地降低细胞活力，并活化半胱天冬酶级联、切割聚 (ADP-核糖) 聚合酶 (PARP) 诱导细胞凋亡。
T3674	Hydroxysafflor yellow A 藏红花,羟基红花黄色素A,HSYA,Safflomin A	TGF-beta/Smad	Stem Cells
	Hydroxysafflor yellow A (Safflomin A) 是一种黄酮类天然产物，从中药红花中分离得到，具有抗癌作用。
TN1433	Batatasin III	FAK; Others; Akt	Angiogenesis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Batatasin III 通过抑制上皮间质转化和 FAK-AKT 信号来抑制癌症迁移和侵袭，并具有抗癌活性。 Batatasin III 对整株生长有长期抑制作用，显示出抑制萌发活性。
T4915	β-Glycerophosphate disodium salt hydrate	Phosphatase; Endogenous Metabolite	Metabolism
	β-Glycerophosphate disodium salt hydrate 是一种磷酸酶抑制剂，是内源性代谢产物的一种。
T3S2312	Poncirin 枸橘苷,Isosakuranetin-7-neohesperidoside	Apoptosis; Others	Apoptosis; Others
	Poncirin (Isosakuranetin-7-neohesperidoside) 是从三叶草中分离出来的一种天然产物，具有抗炎活性。它防止脂肪生成，增强间充质干细胞中的成骨细胞分化，增加骨矿物质密度，改善小梁微结构，可能反映 GIO 小鼠的骨形成增加和骨吸收减少。
TL0008	Gigantol	Wnt/beta-catenin; Glucosidase	Cytoskeletal Signaling; Metabolism; Stem Cells
	Gigantol 是一种联苄基化合物，从几种药用兰花中获得，是一种Wnt/β-catenin 通路抑制剂，具有抗肿瘤活性。
T6S1315	Oroxylin A 千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether	Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy	Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮，具有较强的抗癌作用。
TN6568	Glycinol
	Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity.
TN4082	Friedelin 3,4-lactone	Others	Others
	Friedelin-3,4-lactone has a promotion effect on the inducing proliferation of rat mesenchymal stem cells(rMSCs).
TN3215	7,4'-Dihydroxy-8-methylflavan	Others	Others
	7,4'-Dihydroxy-8-methylflavan can significantly promote mesenchymal stem cells (MSCs) osteogenic differentiation by increasing the levels of alkaline phosphatase (ALP) activity. 7,4'-Dihydroxy-8-methylflavan also has free radical scavenging properties.

天然产物

Cat.No: T3862

Target: NF-κB, Integrin

3-Butylidenephthalide

Cat.No: T3S2072

Synonym: Butylidene phthalide,n-Butylidenephthalide,丁烯基苯酞,丁烯基苯酞；丁烯基酞内酯

Target: Parasite, Glucosidase

Methacycline hydrochloride

Cat.No: T0518

Synonym: Rondomycin,盐酸甲烯土霉素,盐酸美他环素,Methacycline HCl

Target: ribosome, Antibacterial, Antibiotic

N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide

Cat.No: TN7036

Synonym: (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14

Target: Wnt/beta-catenin

19-Hydroxybufalin

Cat.No: TN1198

Target: Others

Cat.No: TN2081

Target: MAPK

Ecliptasaponin A

Cat.No: T2S0690

Synonym: 早莲苷 A,旱莲苷A,Echinocystic acid-3-o-glucoside

Target: Others

Cat.No: T4S1383

Synonym: Aescin IA,Escin IA;Aescin IA,Escin IA

Target: HIV Protease

trans-Trimethoxyresveratrol

Cat.No: T3330

Synonym: trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,白藜芦醇三甲醚,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene

Target: Reactive Oxygen Species

3,6-Dihydroxyflavone

Cat.No: T7982

Target: Others

Hydroxysafflor yellow A

Cat.No: T3674

Synonym: 藏红花,羟基红花黄色素A,HSYA,Safflomin A

Target: TGF-beta/Smad

Cat.No: TN1433

Target: FAK, Others, Akt

β-Glycerophosphate disodium salt hydrate

Cat.No: T4915

Target: Phosphatase, Endogenous Metabolite

Cat.No: T3S2312

Synonym: 枸橘苷,Isosakuranetin-7-neohesperidoside

Target: Apoptosis, Others

Cat.No: TL0008

Target: Wnt/beta-catenin, Glucosidase

Cat.No: T6S1315

Synonym: 千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether

Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy

Cat.No: TN6568

Friedelin 3,4-lactone

Cat.No: TN4082

Target: Others

7,4'-Dihydroxy-8-methylflavan

Cat.No: TN3215

Target: Others

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼