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DMBA

产品编号 T36696 CAS 57-97-6

7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzymes, including the cytochrome P450 (CYP450) isoform CYP1B1, as well as microsomal epoxide hydrolase (mEH), producing a variety of reactive metabolites that form DNA adductsin vivo, and it has been commonly used to induce tumor formation in various rodent models.2,3,1DMBA increases proliferation and migration of, and induces epithelial-to-mesenchymal transition (EMT) in, MCF-10A breast cancer cells when used at a concentration of 5 μM.4It also has immunosuppressant activity, inhibiting proliferation of isolated mouse splenic B- and T cells stimulatedex vivowith LPS or concanavalin A , respectively, when administered at doses of 50 and 100 mg/kg.5Intragastric administration of DMBA (20 mg/animal) induces formation of mammary gland tumors in rats.6DMBA (50 μg/animal), in combination with phorbol 12-myristate 13-acetate , initiates papilloma formation in a rat two-stage model of skin carcinogenesis.7

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DMBA, CAS 57-97-6

规格	价格/CNY	货期
100 mg	￥ 768	现货
250 mg	￥ 1,750	现货
500 mg	￥ 2,460	现货
1 g	￥ 4,420	35日内发货

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述

分子量	256.34
分子式	C20H16
CAS No.	57-97-6

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 10 mg/mL

DMF: 20 mg/mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Rengarajan, T., Rajendran, P., Nandakumar, N., et al.Exposure to polycyclic aromatic hydrocarbons with special focus on cancerAsian Pac. J. Trop. Biomed.5(3)182-189(2015) 2. Csiszar, A., Balasubramanian, B., Tarantini, S., et al.Chemically induced carcinogenesis in rodent models of aging: Assessing organismal resilience to genotoxic stressors in geroscience researchGeroscience41(2)209-227(2019) 3. Huberman, E., Chou, M.W., and Yang, S.K.Identification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cellsProc. Natl. Acad. Sci. U.S.A.76(2)862-866(1979) 4. Kwon, Y.-J., Ye, D.-J., Baek, H.-S., et al.7,12-Dimethylbenz[α]anthracene increases cell proliferation and invasion through induction of Wnt/β-catenin signaling and EMT processEnviron. Toxicol.33(7)729-742(2018) 5. Gao, J., Lauer, F.T., Dunaway, S., et al.Cytochrome P450 1B1 is required for 7,12-dimethylbenz(a)-anthracene (DMBA) induced spleen cell immunotoxicityToxicol. Sci.86(1)68-74(2005) 6. Barros, A.C.S.D., Muranaka, E.N.K., Mori, L.J., et al.Induction of experimental mammary carcinogenesis in rats with 7,12-dimethylbenz(a)anthraceneRev. Hosp. Clin. Fac. Med. Sao Paulo59(5)257-261(2005) 7. V?h?tupa, M., Pemmari, T., Junttila, I., et al.Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)J. Vis. Exp.154(2019)

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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