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Search Results for " cardioprotective "

55

抑制剂 & 化合物

23

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21640	Talinolol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Talinolol 是一种长效、心脏选择性的 β1-肾上腺素能受体阻滞剂，具有心脏保护和抗高血压作用。它也是众所周知且经常使用的 P-糖蛋白 (P-gp) 活性探针底物。
T1940	BTB06584	RAAS; ATPase	Endocrinology/Hormones; Membrane transporter/Ion channel
	BTB06584 是选择性依赖 IF1 的线粒体F1Fo-ATPase 抑制剂，可延迟缺血性细胞死亡。
T24109	GSK329 GSK 329,GSK-329	Others	Others
	GSK329 是一种有效的选择性 TNNI3 相互作用激酶 (TNNI3K) 抑制剂。 GSK329 在缺血/再灌注心脏损伤模型中表现出积极的心脏保护作用。
T9714	Atpenin A5	Potassium Channel	Membrane transporter/Ion channel
	Atpenin A5 是高度特异性的complex II 抑制剂，IC50为 ~10 nM。Dolastatin 10也是有效的mKATP 通道激动剂，具有心脏保活的作用。
T21919	UCF 101	Apoptosis	Apoptosis
	UCF 101 是竞争性的促凋亡蛋白酶Omi/HtrA2选择性抑制剂。它对 MI/R 损伤具有明显的心脏保护作用，还具有一定的神经保护作用。它在 543 nm 处具有天然的红色荧光，可用于监视其进入哺乳动物细胞的能力。
T0075	Nicorandil SG-75,尼可地尔	Potassium Channel	Membrane transporter/Ion channel
	Nicorandil (SG-75) 是一种有效的钾通道激活剂，靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯，具有血管舒张和心脏保护作用，并具有治疗心绞痛和缺血性心脏病的潜力。
T12478L	Pinacidil 吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134	Potassium Channel	Membrane transporter/Ion channel
	Pinacidil (P 1134) 是钾通道的有效激活剂。Pinacidil 通过打开 K+-通道使血管平滑肌超极化，显示出抗高血压活性。它显著改善再灌注功能和心脏顺应性。它具有直接的心脏保护作用。
T19335	Danegaptide Hydrochloride GAP-134 (Hydrochloride),ZP 1609 Hydrochloride,(4R)-甘氨酰基-4-(苯甲酰基氨基)-L-脯氨酸盐酸盐	Gap Junction Protein	Cytoskeletal Signaling
	Danegaptide Hydrochloride (GAP-134 (Hydrochloride)) 是一种具有口服活性的间隙连接蛋白选择性修饰剂，具有抗心律不齐的作用。
T68077	Furnidipine
	Furnidipine 显著降低了 AoD 和 AF 且在大鼠模型中低剂量给药时有抗心律失常和心脏保护作用。
T25859	Necrostatin-7 Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7	Apoptosis	Apoptosis
	Necrostatin-7 (Necrostatin 7) 是一种坏死性凋亡抑制剂，具有心脏保护作用，可抑制 RANK-NFATc1 信号传导并减弱巨噬细胞向破骨细胞的分化。
T8493	Ingliforib GPi 296,CP 368296	Phosphorylase	Metabolism
	Ingliforib (CP 368296) 是glycogen phosphorylase 抑制剂，能够抑制肝脏、肌肉和大脑的 glycogen phosphorylase ，其IC50值分别为 52，352 和 150 nM，具有心脏保护的作用。
T37807	JTV 519 fumarate
	Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo. Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID:17313373 \|Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID:17994112 \|...
T7845	BTZO-1	Apoptosis	Apoptosis
	BTZO-1 是一种具有心脏保护活性的抗氧化反应元件激活剂。它可以结合巨噬细胞迁移抑制因子，结合的Kd 值为 68.6 nM，并且其结合需要 N 末端 Pro1。
T6454	CORM-3 CORM3,(OC-6-44)-三羰基氯(甘氨酸基)钌	Others; NF-κB; NOD-like Receptor (NLR)	Immunology/Inflammation; NF-κB; Others
	CORM-3 是一种 CO 释放分子，能够减少 NLRP3炎症小体的激活，可以减弱 NF-κB p65的核异位，减少 ROS 的生成，并提高细胞内谷胱甘肽和超氧化物歧化酶的水平。
T10874	CP-060	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	CP-060 是一种 Ca2+ 拮抗剂，能够抑制 Ca2+ 过载，具有抗氧化、保护心脏的作用。
T75098	HIF-PHD-IN-3	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	HIF-PHD-IN-3 是一种有效的 hiPSC-CM 心脏保护支架，对 HIF-PHD 有潜在的抑制作用，可调节血红素加氧酶-1，可用于研究贫血。
T37379	Protectin D1 Neuroprotectin D1,NPD1	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Protectin D1 (Neuroprotectin D1) 是神经细胞产生的神经保护素，是一种潜在的心脏保护剂。Protectin D1 通过调节 PI3K/AKT 信号通路缓解心肌缺血/再灌注损伤，抑制咪喹莫特诱导的银屑病样皮肤炎症。
T16812	RWJ-67657 JNJ 3026582	p38 MAPK	MAPK
	RWJ-67657 (JNJ 3026582) 是一种可口服的选择性p38α和p38β抑制剂，IC50分别为 1 和 11 μM。它是心脏保护剂，具有抗炎和抗肿瘤活性。
T16420	P-1075	Potassium Channel	Membrane transporter/Ion channel
	P-1075 是磺酰脲受体2相关的 ATP 敏感性的钾通道(SUR2-KIR6)的激活剂，EC50为 45 nM。它在兔子中通过打开线粒体 K (ATP) 通道产生活性氧，产生保护心脏的功效。
T24270	KS370G KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide
	KS370G (Caffeic Acid Phenethyl Amide) 抑制 UUO 诱导的肾纤维化标志物表达。KS370G 是一种具有口服活性的降糖和心血管保护剂，可减少梗阻肾脏中胶原蛋白的沉积，并显著降低肾脏炎症趋化因子/粘附分子和单核细胞标志物的表达，改善压力过载小鼠心脏左室肥厚和功能。KS370G 可用于研究肾阻塞性肾病。
T14506	BAY 60-6583	Others; Adenosine Receptor	GPCR/G Protein; Neuroscience; Others
	BAY 60-6583 是一种强效、高亲和力的腺苷 A2B 受体激动剂（EC50 = 3 nM），对A2B 受体的亲和力超过对 A1、A2A 和 A3 受体的亲和力。BAY 60-6583 在心肌缺血模型中具有心脏保护作用。BAY 60-6583 与小鼠、兔子和狗 A2BAR 的结合 Ki 值分别为 750 nM、340 nM 和 330 nM。
T36569	KR-32568	Sodium Channel	Membrane transporter/Ion channel
	KR-32568是一种钠/氢交换器1（NHE-1）抑制剂（IC50：230 nM）。KR-32568具有强大的心脏保护作用。当使用浓度为10μM 时，它能在离体的缺血大鼠心脏模型中恢复心脏收缩功能。KR-32568（0.3mg/kg）在缺血和再灌注损伤的大鼠模型中减少了心肌梗死的大小。
T26842	Bms 188107 Bms188107,Bms-188107
	Bms 188107 is a calcium antagonist, it has cardioprotective effects.
T28656	Sabiporide BIIB 722CL
	Sabiporide is a NHE-1 inhibitor and a cardioprotective agent.
T69097	ARD-353
	ARD-353 is a nonpeptide delta receptor agonist with cardioprotective effects.
T12709	Resveratrol analog 2	Others	Others
	Resveratrol analog 2 is an analog of Resveratrol. Resveratrol is a natural polyphenolic phytoalexin with possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.
T12708	Resveratrol analog 1	Others	Others
	Resveratrol analog 1 is an analog of Resveratrol. Resveratrol is a natural polyphenolic phytoalexin with possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties.
T30487	BMS 180448 BMS-180448,BMS180448
	BMS 180448 is a prototype mitochondrial ATP-sensitive K+ (Mitok (ATP)) channel opener with cardioprotective and vasodilating properties.
T31191	Dagapamil hydrochloride
	Dagapamil hydrochloride 是一种钙通道阻滞剂。Dagapamil hydrochloride 在动物模型中具有降压、抗心律失常、心脏保护、抗过敏和抑制血小板聚集的作用。
T31191L	Dagapamil Dagapamilum
	Dagapamil 是一种钙通道阻滞剂。Dagapamil 在动物模型中具有降压、抗心律失常、心脏保护、抗过敏和抑制血小板聚集的作用。
T11731	JTV-519 free base K201 free base	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	JTV-519 free base (K201 free base), recognized for its antiarrhythmic and cardioprotective properties, functions as a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and serves as a partial agonist of ryanodine receptors in striated muscle.
T11732	JTV-519 hemifumarate K201 hemifumarate	MELK	PI3K/Akt/mTOR signaling
	JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle.
T37252	Chitoheptaose heptahydrochloride
	Chitoheptaose heptahydrochloride is a chitosan oligosaccharide with antioxidant, anti-inflammatory, antiapoptotic, and cardioprotective properties. It effectively promotes the growth and photosynthesis parameters of wheat seedlings[1][2].
T61540	F15845
	F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarction. Furthermore, F 15845 finds utility in the investigation of myocardial functional impairment [1].
T28400	Phenoprolamine Hydrochloride phenoprolamine,DDPH
	Phenoprolamine Hydrochloride is an adrenergic α1 receptor antagonist with potent antihypertensive, neuroprotective and cardioprotective effects. Phenoprolamine Hydrochloride inhibits CYP2D and CYP3A activities and down-regulates their mRNA transcription a
T78092	UCL-TRO-1938	PI3K	PI3K/Akt/mTOR signaling
	UCL-TRO-1938为一种有效的PI3Kα变构激活剂，EC50约60 μM。该化合物能够诱导细胞增殖，并具备心脏保护及神经再生功能。
T80070	PKCβII Peptide Inhibitor I	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	PKCβII Peptide Inhibitor I 为一种特定的PKCβII抑制剂。在大鼠心脏缺血/再灌注损伤模型中，该化合物显著表现出心脏保护效应，并能有效预防血管内皮功能障碍。
T76191	GLP-1(28-36)amide TFA
	GLP-1(28-36)amide TFA，为GLP-1 C-端九肽段，主要通过中性内肽酶（NEP）裂解GLP-1生成。该化合物作为一种抗氧化剂，能靶向线粒体，抑制线粒体通透性转变（MPT），显示出抗糖尿病和心脏保护的功效。
T63160	AD011
	AD011 是一种双重的 cACE/NEP 抑制剂。AD011 是通过先前报道的 C 域选择性 ACE 抑制剂赖诺普利-色氨酸合成的。AD011 显示出提供高效抗高血压和心脏保护作用的潜力。
T60276	Cyclocreatine phosphate
	Cyclocreatine phosphate 是一种抗肿瘤剂。Cyclocreatine phosphate 是环肌酸 (CCr) 的活性形式，环肌酸是肌酸激酶的底物类似物。环肌酸及其水溶性衍生物 Cyclocreatine phosphate (CCrP) 是有效的心脏保护药物。Cyclocreatine phosphate 可用于癌症研究。
T11731L	JTV-519 Formate JTV-519 Formate (145903-06-6 Free base)	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	JTV-519 Formate 是一种 Ca2+ 依赖性的肌质网 Ca2+ 刺激的 ATP 酶 (SERCA) 阻断剂，同时也是横纹肌中兰尼碱受体 (ryanodine receptors) 的部分激动剂。JTV-519 Formate 显示出抗心律失常作用，是一种心脏保护剂。
T62288	AD013
	AD013 是一种双重的 cACE 和 NEP 抑制剂。AD013 是通过 C 域选择性 ACE 抑制剂赖诺普利-色氨酸合成。AD013 具有潜力提供强效抗高血压和心脏保护作用。
T62831	AD012
	AD012 是一种 cACE/NEP 的双重抑制剂。AD012 利用先前报道的 C 域选择性 ACE 抑制剂赖诺普利-色氨酸合成。AD012 具有潜力提供强效抗高血压和心脏保护作用。
T81485	Phoenixin-14 TFA PNX-14 TFA
	Phoenixin-14 (PNX-14) TFA 是具抗焦虑、心脏保护及神经保护效果的穿透大脑屏障神经肽。它通过上调GnRH受体mRNA调控垂体促性腺激素分泌，并促进胰岛素释放。此外，Phoenixin-14 TFA保护小鼠免受缺血/再灌注(IR)伤害，通过降低ROS、提高GSH减缓氧化应激。
TP1965	Parstatin(human) Parstatin (human)
	Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apop
TP1966	Parstatin(mouse) Parstatin (mouse)
	Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apo
T37297	Ru360
	Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondria with high affinity (Kd of 0.34 nM). Ru360 has antiarrhythmic and cardioprotective effects[1][2]. Ru360 permeates slowly into the cell, and specifically inhibits mitochondrial calcium uptake in intact cardiomyocytes and in isolated heart. 1 μm Ru360 is taken up by myocardial ce...
T68499	F15845 HBr
	F 15845 is a blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery. F15845 has been shown to selectively inhibit the persistent sodium current of Nav1.5[1] exerting cardioprotective effects following ischemia. In vitro testing showed minimal effects of F15845 on other important ion channels of the heart, including major Ca2+ and K+ channels.[1] This characteristic is thought to account for the limited effect of F15845 to change other heart parameters suc...
T71910	Racemic rasagiline
	Racemic rasagiline，也称为 AGN-1135，是一种单胺氧化酶 B 型抑制剂(MAOI)。然而，在食用富含酪胺的食物的患者中，这种药物的应用可能导致致命的高血压危象。TVP-1022是雷沙吉兰的(S)异构体，具有心脏保护剂的作用。
T35494	(±)11(12)-EET
	(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET.[3]11(12)-EET has been shown, along with 8(9)-EET to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells[4] It also inhibits basolateral 18-pS potassium channels in t...

化合物

Cat.No: T21640

Target: Adrenergic Receptor

Cat.No: T1940

Target: RAAS, ATPase

Cat.No: T24109

Synonym: GSK 329,GSK-329

Target: Others

Cat.No: T9714

Target: Potassium Channel

Cat.No: T21919

Target: Apoptosis

Cat.No: T0075

Synonym: SG-75,尼可地尔

Target: Potassium Channel

Cat.No: T12478L

Synonym: 吡那地尔,S 1230,P 1134,S-1230,P-1134,P1134

Target: Potassium Channel

Danegaptide Hydrochloride

Cat.No: T19335

Synonym: GAP-134 (Hydrochloride),ZP 1609 Hydrochloride,(4R)-甘氨酰基-4-(苯甲酰基氨基)-L-脯氨酸盐酸盐

Target: Gap Junction Protein

Cat.No: T68077

Cat.No: T25859

Synonym: Necrostatin 7,Necrostatin7,Nec 7,Nec-7,Nec7

Target: Apoptosis

Cat.No: T8493

Synonym: GPi 296,CP 368296

Target: Phosphorylase

JTV 519 fumarate

Cat.No: T37807

Cat.No: T7845

Target: Apoptosis

Cat.No: T6454

Synonym: CORM3,(OC-6-44)-三羰基氯(甘氨酸基)钌

Target: Others, NF-κB, NOD-like Receptor (NLR)

Cat.No: T10874

Target: Calcium Channel

Cat.No: T75098

Target: Reactive Oxygen Species

Cat.No: T37379

Synonym: Neuroprotectin D1,NPD1

Target: Akt, PI3K

Cat.No: T16812

Synonym: JNJ 3026582

Target: p38 MAPK

Cat.No: T16420

Target: Potassium Channel

Cat.No: T24270

Synonym: KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide

Cat.No: T14506

Target: Others, Adenosine Receptor

Cat.No: T36569

Target: Sodium Channel

Cat.No: T26842

Synonym: Bms188107,Bms-188107

Cat.No: T28656

Synonym: BIIB 722CL

Cat.No: T69097

Resveratrol analog 2

Cat.No: T12709

Target: Others

Resveratrol analog 1

Cat.No: T12708

Target: Others

Cat.No: T30487

Synonym: BMS-180448,BMS180448

Dagapamil hydrochloride

Cat.No: T31191

Cat.No: T31191L

Synonym: Dagapamilum

JTV-519 free base

Cat.No: T11731

Synonym: K201 free base

Target: FLT

JTV-519 hemifumarate

Cat.No: T11732

Synonym: K201 hemifumarate

Target: MELK

Chitoheptaose heptahydrochloride

Cat.No: T37252

Cat.No: T61540

Phenoprolamine Hydrochloride

Cat.No: T28400

Synonym: phenoprolamine,DDPH

Cat.No: T78092

Target: PI3K

PKCβII Peptide Inhibitor I

Cat.No: T80070

Target: PKC

GLP-1(28-36)amide TFA

Cat.No: T76191

Cat.No: T63160

Cyclocreatine phosphate

Cat.No: T60276

JTV-519 Formate

Cat.No: T11731L

Synonym: JTV-519 Formate (145903-06-6 Free base)

Target: Others, Calcium Channel

Cat.No: T62288

Cat.No: T62831

Phoenixin-14 TFA

Cat.No: T81485

Synonym: PNX-14 TFA

Parstatin(human)

Cat.No: TP1965

Synonym: Parstatin (human)

Parstatin(mouse)

Cat.No: TP1966

Synonym: Parstatin (mouse)

Cat.No: T37297

Cat.No: T68499

Racemic rasagiline

Cat.No: T71910

Cat.No: T35494

Cat. No.	Product Name	Target	Signaling Pathways
T3809	Liriope muscari baily saponins C	Others	Others
	Liriope muscari baily saponins C 是一种L. muscari (Decne.) Baily 的主要活性成分。它已被作为肿瘤转移候选药物进行研究。它具有很强的抗炎、免疫药理和心脏保护作用。
T2763	Panaxadiol 人参二醇,20(R)-Panaxadiol	Others; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Others
	Panaxadiol (20(R)-Panaxadiol) 是从人参根中获得，具有神经保护和抗肿瘤作用，能够抑制程序性细胞死亡配体-1(PD-L1)的表达和肿瘤增殖。
TN2144	Resveratroloside	P450; NO Synthase	Immunology/Inflammation; Metabolism
	Resveratroloside 是α-glucosidase 的竞争性抑制剂，可以对血糖水平进行调节，对心脏具有保护作用。
T5S0833	Astragaloside III	Antioxidant	oxidation-reduction
	Astragaloside III 是一种分离自黄芪中的一种天然产物。
T3735	Tetrahydrocurcumin Sabiwhite,Tetrahydrodiferuloylmethane,四氢姜黄素,HZIV 81-2,Tetrahydro Curcumin	P450; Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Tetrahydrocurcumin (HZIV 81-2) 是从姜黄中发现的一种天然产物，是姜黄素的主要代谢产物，可抑制 CYP2C9和 CYP3A4，具有很强的抗氧化和心脏保护作用。
TN1982	Neoglycyrol	Others	Others
	Neoglycyrol 是分离自甘草的根中的化合物。它是由传统专利药通脉养心丸中筛选得到，具有潜在心肌保护作用。
T3885	ROSIRIDIN 6'-O-Deacetylrosiridoside C,络塞定,(-)-Rosiridin	Others; Monoamine Oxidase	Neuroscience; Others
	Rosiridin (6'-O-Deacetylrosiridoside C) 能够抑制 MAO A 和 MAO B，有潜在的抑郁症和老年性痴呆作用。它在 10 μM 时对 MAO B 的抑制率为 83.8% (pIC50=5.38)。
T6S1101	Astragalin Kaempferol 3-D-glucoside,Kaempferol 3-O-glucoside,kaempferol-3-glucoside,3-Glucosylkaempferol,Astragaline,紫云英苷,Kaempferol 3-β-D-glucopyranoside	Apoptosis; NF-κB	Apoptosis; NF-κB
	Astragalin (Kaempferol 3-O-glucoside) 是一种具有生物活性的天然黄酮类化合物。它具有多种药理特性，包括抗氧化、抗炎、抗癌、神经保护和心脏保护特性。
TN1182	11-Keto-beta-boswellic acid 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸	Leukotriene Receptor; NF-κB; Lipoxygenase	GPCR/G Protein; Metabolism; NF-κB
	11-Keto-beta-boswellic acid 是来自乳香的一种五环三萜酸，具有抗炎活性和剂量依赖性心脏保护作用，主要是由于抑制5-脂氧合酶、白三烯、NF-κB 的激活和肿瘤坏死因子 α 的产生。
TN1969	N-(p-Coumaroyl) serotonin	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	N-(p-Coumaroyl) Serotonin 是从红花种子中分离出来的多酚，具有抗氧化、抗动脉粥样硬化和抗炎作用，常用于动脉粥样硬化的研究。它可改善动脉粥样硬化和主动脉壁膨大。它可降低肌浆网中 PDGF 诱导的对中PDGFR 酪氨酸磷酸化和 Ca2+释放的作用。
TQ0207	Sulforaphane 萝卜硫素	Apoptosis; Nrf2; HDAC	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation
	Sulforaphane 是存在于多种蔬菜中的一种天然异硫氰酸酯。它可以激活Nrf2，并通过 AMPK 依赖性信号传导抑制高糖诱导的胰腺癌。它增加肿瘤抑制蛋白的转录并抑制组蛋白脱乙酰酶的活性，具有抗癌和抗炎活性。
T4518	Licochalcone D	ERK; NF-κB	MAPK; NF-κB
	Licochalcone D 是一种 NF-κB p65的有效抑制剂，是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物，具有抗氧化、抗炎、抗癌等作用。
TN1065	Hirsutine	Apoptosis	Apoptosis
	Hirsutine 是一种来自钩藤的吲哚生物碱，可诱导细胞凋亡，是一种登革热病毒抑制剂，且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。
T4749	Squalene 角鲨烯,Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene	Reactive Oxygen Species; Endogenous Metabolite; Antifungal	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Squalene (AddaVax) 是胆固醇合成的中间产物，具有降血脂、保肝、心脏保护、抗氧化和抗毒活性等多种药理特性。它还具有抗真菌活性，可用于毛癣菌治疗的相关研究。
T3S1553	trans-Cinnamaldehyde Cinnamaldehyde,Cinnamic aldehyde,桂皮醛,反式肉桂醛,Cinnamal,Phenylacrolein	COX; Endogenous Metabolite	Immunology/Inflammation; Metabolism; Neuroscience
	trans-Cinnamaldehyde (Phenylacrolein) 是一种能够用于合成反式肉桂醛-β-环糊精复合物，一种能够食用的抗菌涂层，能够延长鲜切水果的保质期。它是一种能够通过烷基异氰化物与乙炔二羧酸二烷基酯的反应来合成高度多官能的呋喃环。
TN1412	Astringin trans-Astringin,白皮杉醇葡萄糖苷	IL Receptor; Others	Immunology/Inflammation; Others
	Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin in the ischemic and ischemic-reperfused hearts may be correlated with its antioxidant activity and upregulation of NO production.
T40586	Neophytadiene
	Neophytadiene, a diterpene discovered in Turbinaria ornate, showcases desirable bioactive properties including anti-inflammatory, antioxidant, and cardioprotective effects.
T75531	Ladanetin-6-O-β-D-glucopyranoside
	Ladanetin-6-O-β-D-glucopyranoside, 一种活性类黄酮, 具备抗氧化功能，并可应用于心脏保护研究。
TN1642	Ferruginol 铁锈罗汉柏醇	BCL; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis in non-small cell lung cancer (NSCLC) cells.
T81956	Ladanetin-6-O-β-(6′′-O-acetyl)glucoside
	Ladanetin-6-O-β-(6′′-O-acetyl)glucoside 是一种从甘青青兰 (Dracocephalum tanguticum) 全株中提取的黄酮化合物，具备抗氧化特性。该化合物能够保护H9c2心肌细胞免受Doxorubicin(DOX)引起的细胞毒性。
TN1431	Baohuoside VII 宝藿苷,宝藿苷VII	Others	Others
	Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VII in vivo exhibits significant anti
T77201	Rutin trihydrate
	Rutin (Rutoside) trihydrate 是多功能天然黄酮苷，展现出抗氧化、抗炎、抗糖尿病及抗癌效果。此外，该化合物还具有心脏保护和神经保护活性。
T8291	2-Carene	Others	Others
	2-Carene 是一种天然存在的双环单萜，存在于许多精油中，如松树、雪松和柏树。它被发现具有抗炎、抗真菌和抗菌活性，以及抗氧化、抗肿瘤和抗过敏活性，还有神经保护、心脏保护和肝脏保护作用。

天然产物

Liriope muscari baily saponins C

Cat.No: T3809

Target: Others

Cat.No: T2763

Synonym: 人参二醇,20(R)-Panaxadiol

Target: Others, HIF/HIF Prolyl-Hydroxylase

Resveratroloside

Cat.No: TN2144

Target: P450, NO Synthase

Astragaloside III

Cat.No: T5S0833

Target: Antioxidant

Tetrahydrocurcumin

Cat.No: T3735

Synonym: Sabiwhite,Tetrahydrodiferuloylmethane,四氢姜黄素,HZIV 81-2,Tetrahydro Curcumin

Target: P450, Endogenous Metabolite, Autophagy

Cat.No: TN1982

Target: Others

Cat.No: T3885

Synonym: 6'-O-Deacetylrosiridoside C,络塞定,(-)-Rosiridin

Target: Others, Monoamine Oxidase

Cat.No: T6S1101

Synonym: Kaempferol 3-D-glucoside,Kaempferol 3-O-glucoside,kaempferol-3-glucoside,3-Glucosylkaempferol,Astragaline,紫云英苷,Kaempferol 3-β-D-glucopyranoside

Target: Apoptosis, NF-κB

11-Keto-beta-boswellic acid

Cat.No: TN1182

Synonym: 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸

Target: Leukotriene Receptor, NF-κB, Lipoxygenase

N-(p-Coumaroyl) serotonin

Cat.No: TN1969

Target: PDGFR

Cat.No: TQ0207

Synonym: 萝卜硫素

Target: Apoptosis, Nrf2, HDAC

Cat.No: T4518

Target: ERK, NF-κB

Cat.No: TN1065

Target: Apoptosis

Cat.No: T4749

Synonym: 角鲨烯,Nikko Squalane EX,Super Squalene,AddaVax,all-trans-Squalene,trans-Squalene,Spinacene

Target: Reactive Oxygen Species, Endogenous Metabolite, Antifungal

trans-Cinnamaldehyde

Cat.No: T3S1553

Synonym: Cinnamaldehyde,Cinnamic aldehyde,桂皮醛,反式肉桂醛,Cinnamal,Phenylacrolein

Target: COX, Endogenous Metabolite

Cat.No: TN1412

Synonym: trans-Astringin,白皮杉醇葡萄糖苷

Target: IL Receptor, Others

Cat.No: T40586

Ladanetin-6-O-β-D-glucopyranoside

Cat.No: T75531

Cat.No: TN1642

Synonym: 铁锈罗汉柏醇

Target: BCL, PARP, Caspase

Ladanetin-6-O-β-(6′′-O-acetyl)glucoside

Cat.No: T81956

Cat.No: TN1431

Synonym: 宝藿苷,宝藿苷VII

Target: Others

Rutin trihydrate

Cat.No: T77201

Cat.No: T8291

Target: Others

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