首页工具

登录

搜索结果

Search Results for " antagonistic "

51

抑制剂 & 化合物

19

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T23101	o-3M3FBS	Others	Others
	o-3M3FBS 是 m-3M3FBS 的阴性对照。它以独立于 PLC 的机制及拮抗方式抑制内向和外向电流。它以与 m-3M3FBS 竞争的方式增加 [Ca2+]i 增加。
T3630	Relugolix RVT-601,瑞卢戈利,TAK-385	GNRH Receptor	GPCR/G Protein
	Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。
T67957	Pipoxizine
	Pipoxizine 对组胺所致的支气管收缩具有拮抗作用，可用于研究哮喘疾病。
T0147	Clemastine fumarate HS-592 (fumarate),富马酸氯马斯汀,Meclastine fumarate,Meclastine (fumarate)	Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Clemastine fumarate (Meclastine (fumarate)) 是一种合成乙醇胺，具有抗胆碱能、镇静和组胺 H1 拮抗作用。
T78646	Estrogen receptor antagonist 8	Estrogen Receptor/ERR	Endocrinology/Hormones
	Estrogen receptor antagonist8 作为一种雌激素受体ER的有效拮抗剂，在体内展现出抗子宫活性（EC50=4.160 μM）。
T67811	Tefludazine
	Tefludazine 一种具有苯茚酮结构的新型神经抑制剂，是一种具有良好口服活性且与多巴胺和5-羟色胺受体有拮抗作用的化合物。Tefludazine 在小鼠、大鼠和狗的体外和体内测试模型中表现出强大的多巴胺（DA）拮抗活性。Tefludazine 是一种用来治疗精神类疾病的潜在化合物。
T11851	Lin28-let-7a antagonist 1	Others	Others
	Lin28-let-7a antagonist 1 对 Lin28A-let-7a-1 相互作用的 IC50 为 4.03 μM，对 Lin28-let-7a 相互作用有明显的拮抗作用。
T2623	PD98059 PD 98059	ERK; Aryl Hydrocarbon Receptor; MEK; Autophagy	Autophagy; Immunology/Inflammation; MAPK
	PD98059 是一种 MEK 抑制剂，抑制 MEK1 和 MEK2 (IC50=2/50 μM)，具有非 ATP 竞争性。PD98059 也是一种 AHR 的配体而起拮抗作用。PD98059 可以抑制细胞自噬。
T23380	Sonepiprazole	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Sonepiprazole 是D4多巴胺受体选择性拮抗剂，与rD4多巴胺受体，hD4.2多巴胺受体，rD2多巴胺受体和组胺H1受体结合的Ki 分别为 3.6、10.1、5147 和 7430 nM。
T9833	Opiranserin hydrochloride	P2X Receptor; GlyT; 5-HT Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Opiranserin hydrochloride 是甘氨酸转运蛋白 2 型 (GlyT2) 和 5-羟色胺受体 2A (5HT2A) 的双重拮抗剂，IC50 分别为 0.86 和 1.3 μM。它显示对 rP2X3 的拮抗活性 (IC50=0.87 μM)。它正在开发为用于治疗术后疼痛的注射剂。
T23283	2-Methoxyidazoxan monohydrochloride RX 821002 hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	L-Albizziin (2-Methoxyidazoxan monohydrochloride) 是高效的 alpha 2r 肾上腺素受体选择性拮抗剂，对 imidazoline 拮抗作用很小或没有。它对 (豚鼠) alpha 2D 肾上腺素受体 (pKd9.7) 的亲和力明显高于 (兔子) alpha 2A 肾上腺素受体 (pKd8.2)。
T31195	Dalcotidine KU 1257,KU-1257	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Dalcotidine (KU 1257) 是一种新型组胺H2受体拮抗剂，具有组胺H9受体拮抗活性和抗分泌作用，与豚鼠大脑皮层结合的Ki 值为0.040 对分离性豚鼠右心房组胺诱导的正变时反应的拮抗作用的KB 值为0.041。Dalcotidine 提高了溃疡愈合的质量，可能有助于降低溃疡的复发率和复发率。
T67894	Butyzamide	Thrombopoietin Receptor; JAK	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Butyzamide 是一种有效的可口服的Mpl 激活剂，是一种对血小板生成素(TPO)受体具有拮抗作用的新型非肽基分子，促进表达人Mpl (hMpl)的和小鼠pro B 细胞株Ba/F3的增殖，诱导JAK2、STAT3、STAT5和MAPK 的磷酸化。Butyzamide 在小鼠异种移植试验中有助于提升血小板水平。
T9524	Lanthanum trichloride	Others	Others
	Lanthanum trichloride 可用作分析试剂，可用作提取金属镧的原料和石油裂化催化剂。它在医药领域也有一定的作用。例如，研究表明，它对内毒素（LPS）体内作用的拮抗作用对寻找新的有效内毒素拮抗剂有一定的影响，为防治内毒素血症提供了实验依据。
T67959	Pirodomast	Thrombin; Serine Protease	Proteases/Proteasome
	Pirodomast 是血栓素 A（TXA2）合成酶抑制剂。Pirodomast 能抑制白三烯（LT）D4、C4、E4 的形成和血栓素 B2（TXB2）的活性，但对组胺、甲氧胆碱、血清素、LTC4 或血小板活化因子诱导的豚鼠支气管痉挛的拮抗作用较弱或无效。Pirodomast 在体外对豚鼠气管只有微弱的松弛活性。Pirodomast 是一种潜在的抗过敏化合物，在体外可抑制胰蛋白酶的蛋白水解活性，在体内可阻止抗原诱发过敏绵羊的即时和晚期哮喘反应，抑制抗原诱导的过敏绵羊对组胺和卡巴胆碱的气道高反应性。
T23580	20681-S 20681 S
	20681-S has narcotic antagonistic properties and antinociceptive.
T71159	F-0401
	F-0401 is a novel calcium antagonist with platelet-activating factor-antagonistic action.
T68838	Medroxalol hydrochloride
	Medroxalol hydrochloride is an antihypertensive agent that possesses both alpha and beta-adrenergic antagonistic properties.
T68690	Temiverine hydrochloride monohydrate
	Temiverine hydrochloride monohydrate is an anticholinergic drug with calcium antagonistic activity.
T68871	Pipradimadol
	Pipradimadol is a 4,4-disubstituted piperidine derivative with antidepressive and serotonin antagonistic activity.
T70634	Psycholeine
	Psycholeine is isolated from the tropical plant Psychotria oleoides; exhibits somatostatin antagonistic activity on growth hormone secretion.
T69021	Nifedipine HCl
	Nifedipine HCl is a potent vasodilator agent with calcium antagonistic action. It is a useful anti-anginal agent that also lowers blood pressure.
T36597	ISPA-28
	ISPA-28 is a specific antagonist of the plasmodial surface anion channel (PSAC). It exerts its antagonistic effects by direct and reversible binding to CLAG3[1][2].
T38139	Orexin receptor antagonist 2
	Orexin Receptor Antagonist 2 (compound 30), characterized by its potent antagonistic activity with pKis of 7.69 and 9.78, holds promise for insomnia research[1].
T28795	SKI2496 SKI 2496,SKI-2496
	SKI2496 is a potent and orally bioavailableantagonist of Gonadotropin-Releasing Hormone Receptor (hGnRHR IC50 = 0.46 nM; max. LH inh. inh. (%, h)= 84%, 12h; LH inh. (24h) = 76%.). SKI2496 exhibits more selective antagonistic activity toward the human GnRH
T71029	RCC-36 HCl
	Rcc 36 is an active metabolite of temiverine that has inhibitory actions toward the atropine-resistant part of contractions, which may be related to the calcium antagonistic actions of these compounds.
T80183	Muscarinic toxin 7
	Muscarinic toxin 7，一种肽类毒素，特异性地针对毒蕈碱M1受体表现出选择性和非竞争性的拮抗活性。
T25911	Oxycinchophen Magnophenyl,Sintofene,Reumartril,Chinoxone
	Oxycinchophen 是一种喹啉类的有机物，抗风湿病的化合物。它已被用于研究 P- 选择素拮抗活性，DHOD 抑制活性，以及抗炎药对血管平滑肌的作用。
T78013	Pep2-8 TFA
	Pep2-8是增强PCSK9拮抗活性的肽，作用于前蛋白转化酶枯草杆菌蛋白酶/可辛9型(PCSK9)。
T71466	Sdz 210-096
	Sdz 210-096 is a novel opiate antagonist. It is a novel 14 beta-benzyl morphinan derivative with antagonistic actions at mu and kappa opiate receptors. This compound has been characterized for luteinizing hormone (LH) secretion-stimulating effects in a variety of experimental paradigms in the rat.
TP1075	AUNP-12 TFA (1353563-85-5 free base) AUNP-12 TFA,NP-12 TFA
	AUNP-12 TFA (NP-12 TFA) is a polypeptide antagonist in the pd-1 signaling pathway, which has the same antagonistic effect on pd-l1 and pd-l2, and can protect the proliferation and effector function of lymphocytes.
T78778	D3R/MOR antagonist 1	Dopamine Receptor	GPCR/G Protein; Neuroscience
	D3R/MOR antagonist 1 (Compound 114) 为D3R/MOR拮抗剂，其对D3R和MOR的Ki值分别为46.5 nM和691 nM。该化合物通过MOR的部分激动作用可能具有镇痛效果，同时通过D3R的拮抗作用有助于降低阿片类药物的滥用风险。
T79266	Antihypertensive agent 2
	Antihypertensive agent 2 (Compound 4g) 为一种有效的血管紧张素 II 受体 1 拮抗剂，其降血压效能可与Losartan媲美或更胜一筹。
T83487	[Pmp1,Tyr(OEt)2] AVP
	[Pmp1,Tyr(OEt)2] AVP为环状加压素(AVP)的线性拮抗剂，具备相似结构。
T82901	Belrestotug GSK4428859A,EOS884448,EOS-448
	Belrestotug (EOS-448) 是一种抗TIGIT (VSIG9, VSTM3) 的拮抗性人免疫球蛋白 G1 kappa (hIgG1 kappa) 抗体，具备抗肿瘤活性。
T61145	Topiramate lithium
	Topiramate lithium (McN 4853) is a wide-ranging antiepileptic compound with GluR5 receptor antagonistic properties. Its mechanism of action involves enhancing GABAergic activity, inhibiting kainate/AMPA receptors, voltage-sensitive sodium and calcium channels, and increasing potassium conductance. Additionally, this compound inhibits carbonic anhydrase. [1][2][3]
T61347	D4R antagonist-1
	D4R antagonist-1 是一种有效的选择性 D4R 拮抗剂，IC50为 6.87 μM。D4R antagonist-1 具有帕金森病研究潜力。
T75834	Antagonist G TFA
	Antagonist G TFA 作为后叶加压素（vasopressin）的有效拮抗剂，同时对GRP和缓激肽具有弱拮抗作用。此外，Antagonist G 能够诱导AG-1转录，增强癌细胞对化疗的敏感性。
T26751	BBR 2160 BBR-2160,BBR2160
	BBR 2160 is a dihydropyridine derivative belonging to the group of the so-called tiampidine. BBR 2160 has calcium-antagonistic properties in cardiac tissue. Intracellular microelectrodes have been used to characterize the electrophysiological properties o
T80561	Atrosab
	Atrosab是一种人源化IgG1抗TNFR1抗体，具有拮抗作用。它能够抑制TNF诱导的细胞凋亡(apoptosis)，并减少IL-6和IL-8的生成，有助于研究炎症性疾病。
T73132	DS69910557
	DS69910557为高效、选择性的hPTHR1拮抗剂，口服有效。其对PTHR1的拮抗IC50值为0.08 μM。适用于甲状旁腺功能亢进症、恶性肿瘤引起的高钙血症及骨质疏松症研究。
T16399	Opiranserin	P2X Receptor; GlyT; 5-HT Receptor	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Opiranserin 是一种非阿片类和非 NSAID 镇痛候选药物，是 2 型甘氨酸转运蛋白 (GlyT2) 和 5-羟色胺受体 2A (5HT2A) 的双重拮抗剂，IC50分别为 0.86 和 1.3 μM。它可用于术后疼痛的研究，对 rP2X3 有拮抗作用，IC50为0.87 μM。
T62918	GPR84 antagonist 3
	GPR84antagonist 3 (compound 42)为一种高效GPR84(G 蛋白偶联受体 84)拮抗剂，具pIC50值为8.28，表现出对GTPγS的抑制作用，并拥有良好的药代动力学特性。
T60249	RhlR antagonist 1
	RhlR antagonist 1 is a highly effective antagonist of the RhlR protein, showing an IC50 value of 26 μM. It exhibits selective antagonistic activity against RhlR, with minimal effect on LasR and PqsR. RhlR antagonist 1 strongly inhibits biofilm formation in both static and dynamic environments and reduces the production of virulence factors, such as rhamnolipid and pyocyanin, in P. aeruginosa. These characteristics make RhlR antagonist 1 a valuable tool for the development of molecules that modul...
T72492	GnRH-R antagonist 1	GNRH Receptor	GPCR/G Protein
	GnRH-R antagonist 1 (化合物 21a) 是GnRH-R拮抗剂，具有优良口服安全性及膜透性，高亲和力结合GnRH-R（IC50=0.57 nM），并展现出有效体外拮抗活性（IC50=2.18 nM）。该化合物适用于晚期前列腺癌治疗和预防过早LH峰出现的研究。
T80787	WAY-649123
	WAY-649123为一有活性分子，适用于生化反应研究。
T79547	MOR agonist-2	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	MOR agonist-2 (Compound 46) 为D3R拮抗剂及MOR激动剂，其Ki值分别为7.26 nM和564 nM。MOR agonist-2潜在以MOR部分激动机制实现镇痛效果，并通过D3R拮抗降低阿片类药物的滥用风险。
T74415	Imlunestrant tosylate
	Imlunestrant (LY-3484356) tosylate 是口服有效且选择性的雌激素受体(estrogen receptor, ER)降解剂(SERD)，具纯拮抗性。该化合物能持续抑制ER依赖的基因转录与细胞生长，适用于研究ER阳性(ER+)晚期乳腺癌(aBC)与子宫内膜样癌(EEC)。
T78734	Sigma-1 receptor antagonist 5	Sigma receptor	GPCR/G Protein
	Sigma-1 receptor antagonist 5 (compound 12) 是一种 4-吡啶衍生物，既有镇痛活性也是 sigma 受体 (Ki=4.5 nM (σ1R)，10 nM (σ2R)) 及组胺 H3 (hH3R，Ki=7.7 nM，IC50=215 nM) 的拮抗剂。它能够抑制辣椒素引起的痛觉，并展现出对伤害性和神经性疼痛模型的显著疗效。
T70309	Dicetrorelix pamoate
	Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently lutein...

化合物

Cat.No: T23101

Target: Others

Cat.No: T3630

Synonym: RVT-601,瑞卢戈利,TAK-385

Target: GNRH Receptor

Cat.No: T67957

Clemastine fumarate

Cat.No: T0147

Synonym: HS-592 (fumarate),富马酸氯马斯汀,Meclastine fumarate,Meclastine (fumarate)

Target: Autophagy, Histamine Receptor

Estrogen receptor antagonist 8

Cat.No: T78646

Target: Estrogen Receptor/ERR

Cat.No: T67811

Lin28-let-7a antagonist 1

Cat.No: T11851

Target: Others

Cat.No: T2623

Synonym: PD 98059

Target: ERK, Aryl Hydrocarbon Receptor, MEK, Autophagy

Cat.No: T23380

Target: Dopamine Receptor

Opiranserin hydrochloride

Cat.No: T9833

Target: P2X Receptor, GlyT, 5-HT Receptor

2-Methoxyidazoxan monohydrochloride

Cat.No: T23283

Synonym: RX 821002 hydrochloride

Target: Adrenergic Receptor

Cat.No: T31195

Synonym: KU 1257,KU-1257

Target: Histamine Receptor

Cat.No: T67894

Target: Thrombopoietin Receptor, JAK

Lanthanum trichloride

Cat.No: T9524

Target: Others

Cat.No: T67959

Target: Thrombin, Serine Protease

Cat.No: T23580

Synonym: 20681 S

Cat.No: T71159

Medroxalol hydrochloride

Cat.No: T68838

Temiverine hydrochloride monohydrate

Cat.No: T68690

Cat.No: T68871

Cat.No: T70634

Cat.No: T69021

Cat.No: T36597

Orexin receptor antagonist 2

Cat.No: T38139

Cat.No: T28795

Synonym: SKI 2496,SKI-2496

Cat.No: T71029

Muscarinic toxin 7

Cat.No: T80183

Cat.No: T25911

Synonym: Magnophenyl,Sintofene,Reumartril,Chinoxone

Cat.No: T78013

Cat.No: T71466

AUNP-12 TFA (1353563-85-5 free base)

Cat.No: TP1075

Synonym: AUNP-12 TFA,NP-12 TFA

D3R/MOR antagonist 1

Cat.No: T78778

Target: Dopamine Receptor

Antihypertensive agent 2

Cat.No: T79266

[Pmp1,Tyr(OEt)2] AVP

Cat.No: T83487

Cat.No: T82901

Synonym: GSK4428859A,EOS884448,EOS-448

Topiramate lithium

Cat.No: T61145

D4R antagonist-1

Cat.No: T61347

Antagonist G TFA

Cat.No: T75834

Cat.No: T26751

Synonym: BBR-2160,BBR2160

Cat.No: T80561

Cat.No: T73132

Cat.No: T16399

Target: P2X Receptor, GlyT, 5-HT Receptor

GPR84 antagonist 3

Cat.No: T62918

RhlR antagonist 1

Cat.No: T60249

GnRH-R antagonist 1

Cat.No: T72492

Target: GNRH Receptor

Cat.No: T80787

Cat.No: T79547

Target: Opioid Receptor

Imlunestrant tosylate

Cat.No: T74415

Sigma-1 receptor antagonist 5

Cat.No: T78734

Target: Sigma receptor

Dicetrorelix pamoate

Cat.No: T70309

Cat. No.	Product Name	Target	Signaling Pathways
T2S0271	Voacamine 老刺木胺,Voacanginine	Cannabinoid Receptor; P-gp	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Voacamine (Voacanginine) 是非洲马铃果中的一种吲哚生物碱，可抑制多药耐药肿瘤细胞中的 P-糖蛋白作用，具有强效的大麻素 CB1受体拮抗活性。
T4S1659	Xanthotoxol 8-Hydroxypsoralen,8-Hydroxyfuranocoumarin,Psoralen,花椒毒酚,8-Hydroxypsoralene	Reactive Oxygen Species; 5-HT Receptor; Endogenous Metabolite	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Xanthotoxol (Psoralen) 是一种具有生物活性的线性呋喃香豆素，具有很强的抗炎、抗氧化、5-HT 拮抗和神经保护作用等药理活性。
T20939	Bimatoprost acid 17-phenyl trinor PGF2α,17-phenyl trinor Prostaglandin F2α	GPR	Endocrinology/Hormones; GPCR/G Protein
	Bimatoprost acid (17-phenyl trinor PGF2α) 是一种代谢稳定的 PGF2α 类似物，对 FP 受体具有潜在的拮抗活性。与 PGF2α 相比，它与绵羊黄体细胞上的 FP 受体结合的相对效力为 756%。
T6S1885	Benzoylmesaconine Mesaconine 14-benzoate,苯甲酰新乌头原碱	Others	Others
	Benzoylmesaconine (Mesaconine 14-benzoate) 是乌头汤最丰富的组分。其中乌头汤可用于研究类风湿性关节炎。
T6S0659	Rhynchophylline 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin	Calcium Channel; NF-κB	Membrane transporter/Ion channel; Metabolism; NF-κB
	Rhynchophylline (Mitrinermine) 是一种生物碱类化合物，从钩藤中分离得到，具有很高的生物活性，被广泛用于抗炎、神经保护等方面的研究。
T15248	Estetrol Donesta	Estrogen Receptor/ERR; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Estetrol(Donesta) 是可口服且具有选择性核雌激素受体 (estrogen receptor) 调节剂,是一种在怀孕期间由人类胎儿肝脏合成的天然雌激素。Estetrol 对子宫内膜或中枢神经系统有作用，但对乳房有拮抗作用。Estetrol 在低浓度时可能有助于降低血栓形成。Estetrol 可用于缓解更年期症状。
T6491	(-)-(S)-Equol (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	(-)-(S)-Equol (4',7-Dihydroxyisoflavan) 是雌激素受体β的高亲和力配体。
T3915	Ginsenoside Ro 人参皂苷Ro,Chikusetsusaponin 5,Polysciasaponin P3,人参皂苷 Ro,Chikusetsusaponin V	Calcium Channel; Reductase; Prostaglandin Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism
	Ginsenoside Ro (Chikusetsusaponin V) 能降低 TXA2产量，较弱降低 COX-1 和 TXAS 活性，具有 Ca2+拮抗剂的抗血小板作用，IC50为 155 μM。
TN1719	Gymnestrogenin 匙羹藤苷元,(3BETA,4ALPHA,16BETA,21BETA)-齐墩果-12-烯-3,16,21,23,28-五醇	Liver X Receptor	Metabolism
	Gymnestrogenin has a dual LXRα±/α2 antagonistic profile.
TN4821	Pregomisin	PAFR	GPCR/G Protein
	Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M.
TN6500	Microgrewiapine A
	Microgrewiapine A is a selective cytotoxic agent for colon cancer cells over normal colon cells and to exhibit nicotinic receptor antagonistic activity for both the hα3β4 and hα4β2 receptor subtypes.
TN6682	Cyclo(Phe-Gly)
	Cyclo(Phe-Gly) shows weak antagonistic activity against VEGFR2 -CD, it also shows strong inhibitory activity against human cancer cells(KB,KBv200) with LD50 at 6.5 and 11.2 umol/L,respectively.
T3P2855	Chamigrenal	EGFR; NOS; PAFR; COX; Prostaglandin Receptor	Angiogenesis; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors
	β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamigrenal shows platelet-activating factor antagonistic activity and the IC(50)
TN2763	2-Hydroxy-3-methoxybenzoic acid glucose ester	PAFR	GPCR/G Protein
	2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF-induced death at a dose of 300 micrograms/mouse.
TN6678	Cyclo(Tyr-Pro)
	Cyclo(Tyr-Pro) shows antibacterial activity towards several marine bacterial species, it also shows weak antagonistic activity against VEGFR2 -CD. Cyclo(Tyr-Pro) and cyclo(Pro-Val) are toxic to both suspension cells and seedlings of Pinus thunbergii, whic
TN1815	Kadsulignan L	HBV; PAFR	GPCR/G Protein; Microbiology/Virology
	Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC50 value of 2.6 x 10(-5) M.
TN4319	Isopimaric acid	Antifection	Microbiology/Virology
	Isopimaric acid is active against MDR and MRSA strains of S. aureus which are becoming increasingly resistant to antibiotics, the minimum inhibitory concentrations (MIC) are 32-64 microg/mL . Isopimaric acid is also possible that an antagonistic interacti
TN4624	Nantenine	Others	Others
	Nantenine is an acetylcholinesterase inhibitor, it functions as an effective antagonist against a wide range of MDMA-induced effects in mice. Nantenine has anticonvulsant effect, which seems attributable to its stimulation and the resultant decrease of Ca
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Cat.No: T2S0271

Synonym: 老刺木胺,Voacanginine

Target: Cannabinoid Receptor, P-gp

Cat.No: T4S1659

Synonym: 8-Hydroxypsoralen,8-Hydroxyfuranocoumarin,Psoralen,花椒毒酚,8-Hydroxypsoralene

Target: Reactive Oxygen Species, 5-HT Receptor, Endogenous Metabolite

Bimatoprost acid

Cat.No: T20939

Synonym: 17-phenyl trinor PGF2α,17-phenyl trinor Prostaglandin F2α

Target: GPR

Benzoylmesaconine

Cat.No: T6S1885

Synonym: Mesaconine 14-benzoate,苯甲酰新乌头原碱

Target: Others

Rhynchophylline

Cat.No: T6S0659

Synonym: 钩藤碱,Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin

Target: Calcium Channel, NF-κB

Cat.No: T15248

Synonym: Donesta

Target: Estrogen Receptor/ERR, Endogenous Metabolite

Cat.No: T6491

Synonym: (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Cat.No: T3915

Synonym: 人参皂苷Ro,Chikusetsusaponin 5,Polysciasaponin P3,人参皂苷 Ro,Chikusetsusaponin V

Target: Calcium Channel, Reductase, Prostaglandin Receptor

Cat.No: TN1719

Synonym: 匙羹藤苷元,(3BETA,4ALPHA,16BETA,21BETA)-齐墩果-12-烯-3,16,21,23,28-五醇

Target: Liver X Receptor

Cat.No: TN4821

Target: PAFR

Microgrewiapine A

Cat.No: TN6500

Cat.No: TN6682

Cat.No: T3P2855

Target: EGFR, NOS, PAFR, COX, Prostaglandin Receptor

2-Hydroxy-3-methoxybenzoic acid glucose ester

Cat.No: TN2763

Target: PAFR

Cat.No: TN6678

Cat.No: TN1815

Target: HBV, PAFR

Isopimaric acid

Cat.No: TN4319

Target: Antifection

Cat.No: TN4624

Target: Others

Cat.No: T35779

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼