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Search Results for " adipogenesis "

14

抑制剂 & 化合物

22

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9568	SGC-SMARCA-BRDVIII	Epigenetic Reader Domain	Chromatin/Epigenetic
	SGC-SMARCA-BRDVIII 是SMARCA2/4和PB1(5)选择性抑制剂，其Kd 值分别为 35 nM，36 nM 和 13 nM。它还抑制PB1(2)和PB1(3)，Kd 值分别为 3.7 和 2.0 μM。它可阻断 3T3-L1 鼠成纤维细胞的脂肪生成。
T9266	Fatostatin	Lipid; Fatty Acid Synthase	Metabolism
	Fatostatin A 是一种SREBP 活化的特异性抑制剂，能够抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合，抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤活性，能抑制ob/ob 小鼠的高血糖。它抑制细胞中成脂基因的转录。
T1057	Azilsartan TAK-536,阿齐沙坦	RAAS	Endocrinology/Hormones
	Azilsartan (TAK-536) 是一种高活性的血管紧张素Ⅱ1型受体特异性拮抗剂(IC50:2.6 nM)。
T6832	Fatostatin hydrobromide Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin	NPC1L1; Fatty Acid Synthase	Membrane transporter/Ion channel; Metabolism
	Fatostatin hydrobromide (Fatostatin A HBr) 是一种 SREBP 活化的特异性抑制剂，可抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合，抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤作用，能抑制 ob/ob 小鼠的高血糖。它抑制了细胞中成脂基因的转录。
T24182	ISX-1 ISX 1	Others	Others
	ISX-1 抑制脂肪生成并促进成骨细胞生成。 ISX-1 可用于骨质疏松症和骨质减少症的研究。
T30577	BRD0418 BRD 0418,BRD-0418	Others	Others
	BRD0418作为 TRIB1表达的上调因子，导致肝脏脂蛋白代谢从脂肪生成到清除的重新编程。
T7621	6-Thioinosine 6-Mercaptopurine riboside,6-疏基嘌呤核苷,6TI	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	6-Thioinosine (6TI) 是一种嘌呤抗代谢物，是抗脂肪形成剂，能降低PPAR γ和C/EBPα及其目标基因 aP2、CD36、LPL 和 LXRα 的 mRNA 水平。
T77788	Palmitic acid sodium Sodium palmitate,Palmitic acid sodium
	Palmitic acid sodium（Sodium palmitate）是饱和脂肪酸的一种，其在脂肪酸合成中形成。Palmitic acid sodium 能促进多种细胞系脂肪生成及细胞脂肪变性。
T6337	RepSox ALK5 Inhibitor II,SJN 2511,E-616452	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	RepSox (ALK5 Inhibitor II) 是一种 TGFβR-1/ALK5 的抑制剂，可以抑制 ATP 与 ALK5 结合以及 ALK5 自磷酸化 (IC50=23/4 nM)，具有选择性。RepSox 可以诱导 MEFs 细胞的脂肪生成。
T13289	EHP-101 VCE-004.8	Cannabinoid Receptor; HIF/HIF Prolyl-Hydroxylase; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism
	EHP-101 (VCE-004.8) 是一种口服有效的特异性PPARγ和CB2受体双重激动剂，可抑制脯氨酰-羟化酶(PHDs) 并激活HIF 通路。它是一种半合成的多靶点大麻喹啉，可减弱脂肪生成并防止饮食诱导的肥胖，具有抗炎活性。
T61548	Anti-inflammatory agent 22
	Anti-inflammatory agent 22 (compound 14a) is a potent orally active compound with anti-inflammatory properties. It effectively inhibits the production of TNF-α induced by LPS, exhibiting an IC50 value of 14.6 μM. Additionally, Anti-inflammatory agent 22 has demonstrated its ability to prevent adipogenesis and effectively suppress limb lymphedema volume in mice. This compound holds promise for the treatment of inflammation-related conditions, particularly lymphedematous tissue disorders [1].
T36471	Ternatin
	Ternatin is a cyclic heptapeptide first isolated from the mushroom C. versicolor that has been shown to have cytotoxic and anti-adipogenic effects in vitro. It inhibits adipogenesis with an IC50 value of 27 nM and becomes cytotoxic to 3T3-L1 mouse adipocytes at 10-fold higher concentrations. Ternatin is reported to inhibit HCT116 cell proliferation with an IC50 value of 71 nM. Note that this metabolite should not be confused with the plant flavonoid of the same name.
T64171	LXR antagonist 2
	LXR antagonist 2 (compound 10rr) 是一种有效的 LXR (肝 X 受体) 反向激动剂，能够作用于 LXRβ (IC50: 0.36 μM) 和 LXRα (IC50: 2.25 μM)。 LXR antagonist 2 是一种脂肪生成抑制剂，能够下调 LXR 靶基因 SREBP-1c、ACC、FAS 和 SCD-1。LXR antagonist 2 对 Triton WR-1339 诱导的高脂血症小鼠表现出降脂活性。
T72034	LI-2242	Others	Others
	LI-2242是一种强效肌醇六磷酸激酶（IP6K）抑制剂，对 IP6K1、IP6K2、IP6K3和 IPMK 的 IC50s 分别为31 nM、42 nM、8.7 nM 和1944 nM。LI-2242通过减少增强脂质吸收、脂质稳定和脂肪生成的基因的表达，改善了肝脏脂肪变性，增强体外脂肪细胞和肝细胞的线粒体耗氧率（OCR）和胰岛素信号传导。 LI-2242可改善饮食诱导的小鼠肥胖症、高血糖症和肝脂肪变性。LI-2242可用于研究 II 型糖尿病、肥胖症、代谢并发症、静脉血栓和精神疾病。

化合物

SGC-SMARCA-BRDVIII

Cat.No: T9568

Target: Epigenetic Reader Domain

Cat.No: T9266

Target: Lipid, Fatty Acid Synthase

Cat.No: T1057

Synonym: TAK-536,阿齐沙坦

Target: RAAS

Fatostatin hydrobromide

Cat.No: T6832

Synonym: Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin

Target: NPC1L1, Fatty Acid Synthase

Cat.No: T24182

Synonym: ISX 1

Target: Others

Cat.No: T30577

Synonym: BRD 0418,BRD-0418

Target: Others

Cat.No: T7621

Synonym: 6-Mercaptopurine riboside,6-疏基嘌呤核苷,6TI

Target: Nucleoside Antimetabolite/Analog

Palmitic acid sodium

Cat.No: T77788

Synonym: Sodium palmitate,Palmitic acid sodium

Cat.No: T6337

Synonym: ALK5 Inhibitor II,SJN 2511,E-616452

Target: ALK, TGF-beta/Smad

Cat.No: T13289

Synonym: VCE-004.8

Target: Cannabinoid Receptor, HIF/HIF Prolyl-Hydroxylase, PPAR

Anti-inflammatory agent 22

Cat.No: T61548

Cat.No: T36471

LXR antagonist 2

Cat.No: T64171

Cat.No: T72034

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1836	Kudinoside D	LDL; AMPK; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	Kudinoside D 是 Ilex kudingcha 中三萜皂苷的主要天然成分之一。它能够调节 3T3-L1 脂肪细胞中 AMPK 途径，并可抑制脂肪形成。
T3836	Eudesmin	MAPK; S6 Kinase	MAPK; PI3K/Akt/mTOR signaling
	Eudesmin 通过抑制S6K1信号通路来干扰成脂分化，具有抗肿瘤、抗炎和抗菌活性。
T2S0712	Sinigrin 黑芥子苷,Allylglucosinolate,2-Propenylglucosinolate	Others	Others
	Sinigrin (2-Propenylglucosinolate) 是十字花科植物中主要的硫代葡萄糖苷，具有抗脂肪生成作用。它在芥子油苷的分离和鉴定程序中用作参考材料。
T5583	Turanose 松二糖,D-(+)-Turanose	Endogenous Metabolite	Metabolism
	Turanose (D-(+)-Turanose) 是天然存在于蜂蜜中的蔗糖异构体。它具有抗炎和调节脂肪形成的活性。它具有肥胖症和相关慢性病的研究潜力。
T4S1173	Agrimol B 仙鹤草酚B,仙鹤草酚 B	Sirtuin; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Agrimol B 是从仙鹤草中分离得到的一种多酚衍生物，可抑制脂肪形成，降低PPARγ的表达，诱导SIRT1易位和表达。
TN2121	3,5,7,3′,4′-Pentamethoxyflavone 栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether	Others	Others
	3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) 是一种分离自小花山奈中的多甲氧基黄酮。在分化早期，它可以调控转录因子，促进 3T3-L1 前脂肪细胞形成脂肪。
T4S0227	Sinensetin Pedalitin permethyl ether,甜橙素	TNF; PGE Synthase	Apoptosis; Immunology/Inflammation
	Sinensetin (Pedalitin permethyl ether) 是从水果中发现的一种甲基化黄酮，有很强的抗血管和抗炎症的能力。
T13803	N-Oleoyl glycine	Cannabinoid Receptor; Akt; Endogenous Metabolite; PPAR	Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; PI3K/Akt/mTOR signaling
	N-Oleoyl glycine 是一种脂氨酸。在 3T3-L1 脂肪细胞中，N-Oleoyl glycine 通过激活CB1受体和Akt 信号通路来刺激脂肪形成。
T3674	Hydroxysafflor yellow A 藏红花,羟基红花黄色素A,HSYA,Safflomin A	TGF-beta/Smad	Stem Cells
	Hydroxysafflor yellow A (Safflomin A) 是一种黄酮类天然产物，从中药红花中分离得到，具有抗癌作用。
T8184	Fucosterol 岩皂甾醇,岩藻甾醇	PARP; Endogenous Metabolite; PPAR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Fucosterol 是从藻类、海藻或硅藻中分离的一种甾醇，具有抗氧化、抗脂肪、降低血液胆固醇、抗糖尿病和抗癌活性。它通过抑制 PPARα和C/EBPα的表达调控脂肪生成，可用于抗肥胖试剂开发研究。
T3S2312	Poncirin 枸橘苷,Isosakuranetin-7-neohesperidoside	Apoptosis; Others	Apoptosis; Others
	Poncirin (Isosakuranetin-7-neohesperidoside) 是从三叶草中分离出来的一种天然产物，具有抗炎活性。它防止脂肪生成，增强间充质干细胞中的成骨细胞分化，增加骨矿物质密度，改善小梁微结构，可能反映 GIO 小鼠的骨形成增加和骨吸收减少。
TN5137	Tetramethylkaempferol	transporter; PPAR	DNA Damage/DNA Repair; Metabolism
	Tetramethylkaempferol 是一种 PPARγ 激动剂，它可以通过增加脂联素的水平来提高胰岛素敏感性，脂联素是一种与脂肪组织中胰岛素敏感性相关的重要脂肪细胞因子。它可以浓度依赖性地增强甘油三酯的积累，甘油三酯是脂肪生成的标志物。
T4S0878	Prunetin 樱黄素,Prunusetin	ERK; Dehydrogenase; NF-κB	MAPK; Metabolism; NF-κB
	Prunetin (Prunusetin) 是一种O-甲基化异黄酮，具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。
TN4390	Kihadanin B	Akt; PPAR; FOXO1	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
TN3989	Erycibelline	LDL; PPAR	DNA Damage/DNA Repair; Metabolism
	Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.
T81291	Retrofractamide A
	Retrofratamide A为源自Piper chaba果实的酰胺，能够促进3T3-L1细胞的脂肪生成。
TN2228	Soyasaponin Aa 大豆皂苷 AA,大豆皂苷Aa	PPAR	DNA Damage/DNA Repair; Metabolism
	Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα± in 3T3-L1 adipo
T79949	Foenumoside B	PPAR	DNA Damage/DNA Repair; Metabolism
	Foenumoside B为从Lysimachia foenum-graecum中提取的三萜皂苷。该化合物通过激活AMPK信号传导和抑制PPARγ诱导的脂肪生成，调节脂质代谢向脂肪分解方向转变。因其调控作用，Foenumoside B常用于研究肥胖及相关代谢疾病。
T64246	Cinchonine monohydrochloride hydrate
	Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate 是一种天然的、有效的抗疟剂，也是一种人血小板聚集的抑制剂。Cinchonine monohydrochloride hydrate 能够激活内质网应激，诱导的人肝癌细胞凋亡，并可抑制脂肪的生成。
TN4213	Hirsutenone	ERK; EGFR; IL Receptor; NF-κB; Akt; PI3K; Antifection; mTOR; p53; Autophagy	Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filarial effects, it may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-...
TN3366	Ailanthoidol	IL Receptor; NOS; COX; Prostaglandin Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potential as a chemopreventive agent against tumor promotion. Ailanthoidol has anti-adipogenic activit
TN5369	Dehydroleucodine Dehydroleucodin
	Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulat

天然产物

Cat.No: TN1836

Target: LDL, AMPK, PPAR

Cat.No: T3836

Target: MAPK, S6 Kinase

Cat.No: T2S0712

Synonym: 黑芥子苷,Allylglucosinolate,2-Propenylglucosinolate

Target: Others

Cat.No: T5583

Synonym: 松二糖,D-(+)-Turanose

Target: Endogenous Metabolite

Cat.No: T4S1173

Synonym: 仙鹤草酚B,仙鹤草酚 B

Target: Sirtuin, PPAR

3,5,7,3′,4′-Pentamethoxyflavone

Cat.No: TN2121

Synonym: 栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether

Target: Others

Cat.No: T4S0227

Synonym: Pedalitin permethyl ether,甜橙素

Target: TNF, PGE Synthase

N-Oleoyl glycine

Cat.No: T13803

Target: Cannabinoid Receptor, Akt, Endogenous Metabolite, PPAR

Hydroxysafflor yellow A

Cat.No: T3674

Synonym: 藏红花,羟基红花黄色素A,HSYA,Safflomin A

Target: TGF-beta/Smad

Cat.No: T8184

Synonym: 岩皂甾醇,岩藻甾醇

Target: PARP, Endogenous Metabolite, PPAR

Cat.No: T3S2312

Synonym: 枸橘苷,Isosakuranetin-7-neohesperidoside

Target: Apoptosis, Others

Tetramethylkaempferol

Cat.No: TN5137

Target: transporter, PPAR

Cat.No: T4S0878

Synonym: 樱黄素,Prunusetin

Target: ERK, Dehydrogenase, NF-κB

Cat.No: TN4390

Target: Akt, PPAR, FOXO1

Cat.No: TN3989

Target: LDL, PPAR

Retrofractamide A

Cat.No: T81291

Cat.No: TN2228

Synonym: 大豆皂苷 AA,大豆皂苷Aa

Target: PPAR

Cat.No: T79949

Target: PPAR

Cinchonine monohydrochloride hydrate

Cat.No: T64246

Cat.No: TN4213

Target: ERK, EGFR, IL Receptor, NF-κB, Akt, PI3K, Antifection, mTOR, p53, Autophagy

Cat.No: TN3366

Target: IL Receptor, NOS, COX, Prostaglandin Receptor, PPAR

Dehydroleucodine

Cat.No: TN5369

Synonym: Dehydroleucodin

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