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Search Results for " mek1 "

57

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T63547	MEK1/2-IN-2
	MEK1/2-IN-2 是有效的、ATP 竞争性的 MEK1/2 抑制剂，对野生型 MEK1/2 和一组 MEK1/2 突变细胞表现出同等的抑制效果。
T79144	PROTAC MEK1 Degrader-1	PROTACs	PROTAC
	PROTACMEK1Degrader-1是一种针对MEK1的PROTAC，显示出pIC50值为7.0。该化合物由MEK1抑制剂与von Hippel-Lindau配体构成，能够抑制ERK1/2的磷酸化，并对A375细胞展现出抗增殖活性。
T80543	STE-MEK1(13) ERK Activation Inhibitor Peptide,Ste-MPKKKPTPIQLNP-NH₂	ERK	MAPK
	STE-MEK1(13)（Ste-MPKKKPTPIQLNP-NH2）为一细胞渗透性ERK1/2抑制剂，IC50值为13-30μM，可抑制ERK1/2磷酸化。
T76556	MEK1 Derived Peptide Inhibitor 1
	MEK1Derived Peptide Inhibitor 1，一种肽抑制剂，以IC50值30 μM抑制MEK1激活ERK2。适用于细胞渗透性研究。
T72407	c-Met/MEK1/Flt-3-IN-1
	Antiproliferative against-3 具有良好的抗癌细胞增殖活性，对 Hela、A549 和 MCF-7 的细胞的 IC50值分别为 0.21 µM、0.39 µM 和 0.33 µM。Antiproliferative against-3 (comp 33) 剂量依赖性的诱导 A549 细胞的凋亡，并将细胞阻滞在 G1 期。
T76557	Myristoyl-MEK1 Derived Peptide Inhibitor 1
	Myristoyl-MEK1 Derived Peptide Inhibitor 1 是MEK1Derived Peptide Inhibitor 1 的豆蔻酰化形式。Myristoyl-MEK1 Derived Peptide Inhibitor 1 抑制ERK 的激活，IC50为 10 μM。
T6636	Refametinib BAY 86-97661,瑞法替尼//瑞美替尼,BAY 869766,RDEA119	MEK	MAPK
	Refametinib (RDEA119) 是可口服的、非 ATP 竞争和选择性的 MEK1/MEK2变构抑制剂，IC50分别为 19 和 47 nM。
T6692	TAK-733 TAK733,TAK 733	MEK	MAPK
	TAK-733 是选择性 MEK 抑制剂，IC50为 3.2 nM。
T6131	Pimasertib AS703026,MSC1936369B,N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺,SAR 245509	MEK	MAPK
	Pimasertib (AS703026) 是一种高效选择性和ATP 非竞争性的MEK1/2抑制剂，可用于癌症研究。
T5857	Trametinib (DMSO solvate) Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate)	Apoptosis; MEK	Apoptosis; MAPK
	Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) 是一种口服有效的 MEK 抑制剂，抑制 MEK1 和 MEK2 的 IC50分别为 2 nM。它还能激活自噬，诱导凋亡。
T6218	Selumetinib ARRY-142886,司美替尼,AZD6244	Apoptosis; ERK; MEK	Apoptosis; MAPK
	Selumetinib (AZD6244) 是一种高效选择性的，非 ATP 竞争性的MEK1/2抑制剂，抑制 MEK1 的IC50为14 nM。它抑制 MEK1/2 磷酸化水平。
T5412	RO4987655 CH4987655,RG7167	MEK	MAPK
	RO4987655 (RG7167) 是一种具有口服活性和高选择性的 MEK 抑制剂，抑制MEK1/MEK2，IC50为 5.2 nM。
T2443	CI-1040 PD 184352	Apoptosis; MEK	Apoptosis; MAPK
	CI-1040 (PD 184352) 是一种有口服活性的高度特异性MEK 小分子抑制剂，对 MEK1 的IC50值为 17 nM 。
T6843	GDC-0623 G-868,GDC0623,RG 7421,MEK inhibitor 1	Apoptosis; MEK	Apoptosis; MAPK
	GDC-0623 (RG 7421) 是一种 ATP 竞争性的MEK1抑制剂，Ki 值为 0.13 nM。它对 A375 细胞中 BRAFV600E 的 EC50值为 7 nM，而对 HCT116 细胞中 KRAS (G13D)的 EC50值为 42 nM。
T2125	Trametinib GSK1120212,曲美替尼,JTP-74057	Apoptosis; MEK; Autophagy	Apoptosis; Autophagy; MAPK
	Trametinib (GSK1120212) 是一种 MEK 抑制剂，抑制 MEK1 和 MEK2 (IC50=0.7/0.9 nM)，具有 ATP 非竞争性和口服活性。Trametinib 可以激活自噬，诱导凋亡。
T2708	SL327 SL 327,SL-327	MEK; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; MAPK
	SL327 是能通过血脑屏障运输的选择性 MEK1/2 抑制剂，IC50 分别为 0.18 和 0.22 μM。
T2623	PD98059 PD 98059	ERK; Aryl Hydrocarbon Receptor; MEK; Autophagy	Autophagy; Immunology/Inflammation; MAPK
	PD98059 是一种 MEK 抑制剂，抑制 MEK1 和 MEK2 (IC50=2/50 μM)，具有非 ATP 竞争性。PD98059 也是一种 AHR 的配体而起拮抗作用。PD98059 可以抑制细胞自噬。
T6223	U0126-EtOH U0126 Ethanol,U0126	Mitophagy; Influenza Virus; MEK; Autophagy	Autophagy; MAPK; Microbiology/Virology
	U0126-EtOH (U0126 Ethanol) 是一种非 ATP 竞争性的选择性MEK1和MEK2抑制剂，IC50分别为 72 nM 和 58 nM。U0126-EtOH 可抑制自噬和线粒体自噬。
T6152	PD318088	MEK	MAPK
	PD318088 是非 ATP 竞争性的MEK1/2变构抑制剂，是 PD184352 的结构类似物。它在MEK1 活性位点与 ATP 结合位点相邻的区域与 ATP 同时结合，可用于癌症研究。
T6971	Ro 5126766 CH5126766,Avutometinib,VS-6766,RO5126766	Raf; MEK	MAPK
	Ro 5126766 (CH5126766) 是双重MEK/RAF 抑制剂，抑制BRAFV600E、CRAF、MEK 和 BRAF，IC50分别为 8.2、56、160 和 190 nM。
T3623	Cobimetinib 可美替尼,考比替尼,RG7420,XL518,GDC-0973	Apoptosis; MEK	Apoptosis; MAPK
	Cobimetinib (GDC-0973) 是一种可口服的 MEK1选择性抑制剂，抑制MEK1的IC50为4.2 nM。
T6083	AZD8330 ARRY-424704,ARRY-704	ERK; MEK	MAPK
	AZD8330 (ARRY-704) 是非竞争性的 MEK1/MEK2抑制剂，IC50为 7 nM。
T2508	Binimetinib ARRY-438162,ARRY-162,MEK162	MEK; Autophagy	Autophagy; MAPK
	Binimetinib (ARRY-162) 是一种可口服的选择性 MEK1/2抑制剂，抑制MEK 的IC50为 12 nM。
T2253	TCS PIM-1 1 3-氰基-4-苯基-6-(3-溴-6-羟基苯基)-2(1H)-吡啶酮,SC 204330	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	TCS PIM-1 1 (SC 204330) 是一种特异性有效的 ATP 竞争性 Pim-1 激酶抑制剂，IC50为 50 nM，对 MEK1/MEK2 和 Pim-2 表现出良好的特异性，IC50值大于 20000 nM。
T6324	(E/Z)-BIX02188 334949-59-6	ERK; MEK; TGF-beta/Smad	MAPK; Stem Cells
	BIX02188 是一种特异性 MEK5 抑制剂 (IC50: 4.3 nM)，也抑制 ERK5 催化活性 (IC50: 810 nM)，并且不抑制密切相关的激酶 MEK1/2、JNK2 和 ERK2。
T6039	TAK-285 TAK285,TAK 285	EGFR; MEK; HER; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Tyrosine Kinase/Adaptors
	TAK-285 是一种新型 HER2 和 EGFR(HER1) 双重抑制剂，IC50 分别为 17 和 23 nM。它可穿过血脑屏障，有抗肿瘤活性，对 HER1/2 的选择性是 HER4 的 10 倍以上。
T6525	GW 5074 GW5074,3-(3,5-二溴-4-羟基苯亚甲基)-5-碘-1,3-二氢吲哚-2-酮,Raf1 Kinase Inhibitor I	Apoptosis; Raf	Apoptosis; MAPK
	GW 5074 (Raf1 Kinase Inhibitor I) 是一种有效且特异性的 c-Raf 抑制剂，IC50值为 9 nM。它对 JNK1/2/3、MEK1、MKK6/7、CDK1/2、c-Src、p38 MAP、VEGFR2 或 c-Fms 的活性没有影响。
T27242	EF24 EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone	ERK; MEK; Caspase	Apoptosis; MAPK; Proteases/Proteasome
	EF24 (3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone) 是姜黄素类似物，口服生物利用度高，抗肿瘤作用强。它可增强活化的 Caspase3 及 Caspase9 的水平，并抑制 MEK1 及 ERK 的磷酸化形式的表达。它可以抑制口腔鳞状细胞癌细胞的 MAPK/ERK 信号通路，从而发挥抗肿瘤作用。
T6077	ZM-447439	Apoptosis; MEK; Src; Aurora Kinase	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK; Tyrosine Kinase/Adaptors
	ZM 447439是一种极光激酶 (aurora) 抑制剂，对aurora A 和B 的IC50值分别为110和130 nM。
T6760	APS-2-79 hydrochloride APS-2-79 HCl,APS-2-79	MEK; MAPK	MAPK
	APS-2-79 hydrochloride (APS-2-79 HCl) 是一种 KSR 依赖性的MEK 拮抗剂，可与 ATPbiotin 竞争性地结合到 KSR2-MEK1 复合物内的KSR2。它与 KSR 结合可将 KSR 处于非活性状态，使其无法再结合 RAF 和激活 MEK，从而阻断 Ras-MAPK 信号通路。
T2378	RGB-286638 free base	GSK-3; MEK; JAK; CDK	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	RGB-286638 free base 是一种新型 CDK 抑制剂，抑制cyclin T1-CDK9、cyclin B1-CDK1、cyclin E-CDK2、cyclin D1-CDK4、cyclin E-CDK3和p35-CDK5活性，IC50分别为 1、2、3、4、5 和 5 nM。它也抑制 GSK-3β、TAK1、Jak2 和 MEK1，IC50值分别为 3、5、50和 54 nM。
T21635	PD184161	MEK	MAPK
	PD 184161 是一种口服有效的，时间和浓度依赖的 MEK 抑制剂，IC50为10-100 nM。它诱导抑郁样行为，抑制细胞增殖并诱导细胞凋亡。
T35610	2,5-dimethyl Celecoxib	Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells
	2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂，mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。
T13782	MS432	MEK	MAPK
	MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
T64175	Cobimetinib hemifumarate
	Cobimetinib hemifumarate 是一种有效的、选择性的 MEK1 抑制剂，对 MEK1 的 IC50 值为 4.2 nM。
T23129	PD 334581	Others	Others
	MEK1 inhibitor
T63929	Selumetinib sulfate
	Selumetinib (AZD6244) 是高效的、选择性的、非 ATP 竞争性的 MEK1/2 抑制剂，可抑制 MEK1/2 磷酸化水平，对 MEK1 的 IC50 值为 14 nM。
T71163	Pimasertib HCl
	Pimasertib HCl is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activati...
T64001	MAP855
	MAP855 是一种高效的、选择性的、口服具有活力的具、 ATP 竞争性的 MEK1/2 激酶抑制剂，对 MEK1 ERK2 cascade 的 IC50 值为 3 nM，pERKEC50 值为 5 nM。MAP855 对野生型和突变型 MEK1/2 表现出同等的抑制效果。
T78209	Nedometinib	MEK	MAPK
	Nedometinib是MEK1酪氨酸激酶的抑制剂，具备抗肿瘤活性，适用于皮肤病、皮肤纤维神经瘤和神经纤维瘤病研究。
T69826	U-0126
	U0126 is a highly selective inhibitor of both MEK1 and MEK2, a type of MAPK/ERK kinase. It was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with IC50 of 72 nM for MEK1 and 58 nM for MEK2. U0126 inhibited anchorage-independent growth of Ki-ras-transformed rat fibroblasts by simultaneously blocking both extracellular signal-regulated kinase and mammalian target of rapamycin pathways.
T31126	CX-659S CX659S,UNII-YG2F04AVMQ,CX 659S
	CX-659S is a novel diaminuracil derivative that indirectly inhibits Langerhans cell function by blocking the MEK1/2 -- ERK1/2 pathway in keratinocytes. CX-659S can inhibit the contact hypersensitivity induced by haptens in mice.
T61755	E6201
	E6201 (ER-806201) is a potent dual kinase inhibitor targeting MEK1 and FLT3, inhibiting their activities in an ATP-competitive manner. It effectively suppresses MEK1-induced ERK2 phosphorylation (IC50 = 5.2 nM), MKK4-induced JNK phosphorylation (IC50 = 91 nM), and MKK6-induced p38 MAPK phosphorylation (IC50 = 19 nM). E6201 exhibits anti-tumor and anti-psoriasis effects [1] [2].
T28862	ST-168 ST168,ST 168
	ST-168 is a potent inhibitor of PI3K and MEK. ST-168 displays improved PI3K and MEK1 isoform inhibition. ST-168 demonstrated a 2.8-, 2.7-, 23-, and 2.5-fold improved inhibition toward the PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ isoforms and a 2.2-fold improvement
T68267	RO5068760
	RO5068760 , a substituted hydantoin, is a potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen-activated protein kinase pathway activation. In vitro, RO5068760 demonstrates MEK1 kinase inhibitory activity with an IC50 of 0.025 μM in a cRaf/MEK/ERK cascade assay RO5068760 showed superior efficacy in tumors harboring B-RafV600E mutation.
T68459	RO4927350
	RO4927350 is a potent and highly selective non-ATP-competitive MEK1/2 inhibitor. RO4927350 selectively blocks the MAPK pathway signaling both in vitro and in vivo, which results in significant antitumor efficacy in a broad spectrum of tumor models. RO4927350 inhibits not only ERK1/2 but also MEK1/2 phosphorylation. In cancer cells, high basal levels of phospho-MEK1/2 rather than phospho-ERK1/2 seem to correlate with greater sensitivity to RO4927350. Furthermore, RO4927350 prevents a feedback inc...
T18668	(S,R,S)-AHPC-Me-C10-Br	Others	Others
	(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate that functions as a ligand-linker for E3 ligases. This compound incorporates a VHL E3 ligase linker and MS432, derived from the MEK1/2 inhibitor PD0325901[1].
T40217	PD0325901-O-C2-dioxolane PD0325901-O-C2-dioxolane
	PD0325901-O-C2-dioxolane is a chemical compound primarily composed of the MEK inhibitor PD0325901. It can be utilized, in conjunction with either a VHL or CRBN E3 ligase ligand, for the synthesis of MEK1/2 degrader.
T71722	Angiogenesis inhibitor BT2
	Angiogenesis inhibitor BT2 is a novel inhibitor of angiogenesis and vascular permeability, inhibiting ERK phosphorylation and the expression of FosB/ΔFosB, VCAM-1, and many genes involved in proliferation, migration, angiogenesis, and inflammation, interacting with MEK1, suppressing retinal CD31, pERK, VCAM-1, and VEGF-A165 expression.
T74361	MEK/PI3K-IN-2
	MEK/PI3K-IN-2 (compound 6s) 是一种有效的 MEK/PI3K 抑制剂，其 IC50值分别为 352 nM (MEK1), 107 nM (PI3Kα), 和 137 nM (PI3Kδ)。MEK/PI3K-IN-2 抑制 pAKT 和 pERK1/2 水平。MEK/PI3K-IN-2 对肿瘤细胞具有抗增殖活性。

化合物

Cat.No: T63547

PROTAC MEK1 Degrader-1

Cat.No: T79144

Target: PROTACs

Cat.No: T80543

Synonym: ERK Activation Inhibitor Peptide,Ste-MPKKKPTPIQLNP-NH₂

Target: ERK

MEK1 Derived Peptide Inhibitor 1

Cat.No: T76556

c-Met/MEK1/Flt-3-IN-1

Cat.No: T72407

Myristoyl-MEK1 Derived Peptide Inhibitor 1

Cat.No: T76557

Cat.No: T6636

Synonym: BAY 86-97661,瑞法替尼//瑞美替尼,BAY 869766,RDEA119

Target: MEK

Cat.No: T6692

Synonym: TAK733,TAK 733

Target: MEK

Cat.No: T6131

Synonym: AS703026,MSC1936369B,N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺,SAR 245509

Target: MEK

Trametinib (DMSO solvate)

Cat.No: T5857

Synonym: Trametinib DMSO solvate,GSK-1120212 (DMSO solvate),Trametinib dimethyl sulfoxide,JTP-74057 (DMSO solvate)

Target: Apoptosis, MEK

Cat.No: T6218

Synonym: ARRY-142886,司美替尼,AZD6244

Target: Apoptosis, ERK, MEK

Cat.No: T5412

Synonym: CH4987655,RG7167

Target: MEK

Cat.No: T2443

Synonym: PD 184352

Target: Apoptosis, MEK

Cat.No: T6843

Synonym: G-868,GDC0623,RG 7421,MEK inhibitor 1

Target: Apoptosis, MEK

Cat.No: T2125

Synonym: GSK1120212,曲美替尼,JTP-74057

Target: Apoptosis, MEK, Autophagy

Cat.No: T2708

Synonym: SL 327,SL-327

Target: MEK, DNA/RNA Synthesis

Cat.No: T2623

Synonym: PD 98059

Target: ERK, Aryl Hydrocarbon Receptor, MEK, Autophagy

Cat.No: T6223

Synonym: U0126 Ethanol,U0126

Target: Mitophagy, Influenza Virus, MEK, Autophagy

Cat.No: T6152

Target: MEK

Cat.No: T6971

Synonym: CH5126766,Avutometinib,VS-6766,RO5126766

Target: Raf, MEK

Cat.No: T3623

Synonym: 可美替尼,考比替尼,RG7420,XL518,GDC-0973

Target: Apoptosis, MEK

Cat.No: T6083

Synonym: ARRY-424704,ARRY-704

Target: ERK, MEK

Cat.No: T2508

Synonym: ARRY-438162,ARRY-162,MEK162

Target: MEK, Autophagy

Cat.No: T2253

Synonym: 3-氰基-4-苯基-6-(3-溴-6-羟基苯基)-2(1H)-吡啶酮,SC 204330

Target: Pim

Cat.No: T6324

Synonym: 334949-59-6

Target: ERK, MEK, TGF-beta/Smad

Cat.No: T6039

Synonym: TAK285,TAK 285

Target: EGFR, MEK, HER, Aurora Kinase

Cat.No: T6525

Synonym: GW5074,3-(3,5-二溴-4-羟基苯亚甲基)-5-碘-1,3-二氢吲哚-2-酮,Raf1 Kinase Inhibitor I

Target: Apoptosis, Raf

Cat.No: T27242

Synonym: EF 24,EF-24,3,5-Bis[(2-fluorophenyl)Methylene]-4-piperidinone

Target: ERK, MEK, Caspase

Cat.No: T6077

Target: Apoptosis, MEK, Src, Aurora Kinase

APS-2-79 hydrochloride

Cat.No: T6760

Synonym: APS-2-79 HCl,APS-2-79

Target: MEK, MAPK

RGB-286638 free base

Cat.No: T2378

Target: GSK-3, MEK, JAK, CDK

Cat.No: T21635

Target: MEK

2,5-dimethyl Celecoxib

Cat.No: T35610

Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor

Cat.No: T13782

Target: MEK

Cobimetinib hemifumarate

Cat.No: T64175

Cat.No: T23129

Target: Others

Selumetinib sulfate

Cat.No: T63929

Cat.No: T71163

Cat.No: T64001

Cat.No: T78209

Target: MEK

Cat.No: T69826

Cat.No: T31126

Synonym: CX659S,UNII-YG2F04AVMQ,CX 659S

Cat.No: T61755

Cat.No: T28862

Synonym: ST168,ST 168

Cat.No: T68267

Cat.No: T68459

(S,R,S)-AHPC-Me-C10-Br

Cat.No: T18668

Target: Others

PD0325901-O-C2-dioxolane

Cat.No: T40217

Synonym: PD0325901-O-C2-dioxolane

Angiogenesis inhibitor BT2

Cat.No: T71722

MEK/PI3K-IN-2

Cat.No: T74361

Cat. No.	Product Name	Target	Signaling Pathways
T6S1587	Notoginsenoside R2 三七皂苷R2,20(S)-Notoginsenoside R2,Ginsenoside Ng-R2	Others; Nrf2	Immunology/Inflammation; Others
	Notoginsenoside R2 (20(S)-Notoginsenoside R2) 是一种新分离三七皂苷，表现出对6-OHDA 诱导的氧化应激及细胞凋亡的保护作用。
T5S2361	Epiberberine	ERK; Beta-Secretase; MEK; BACE; AMPK; AChR; AChE	Chromatin/Epigenetic; MAPK; Neuroscience; PI3K/Akt/mTOR signaling
	Epiberberine 是一种从黄连中得到的生物碱，是AChE 和BChE 抑制剂，和非竞争性BACE1抑制剂。在 3T3-L1 细胞分化早期，它能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。它具有抗氧化作用，能够清除 ONOO-，可用于阿尔滋海默症和糖尿病的研究。
T2836	Isorhamnetin 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin	MEK; PI3K; Endogenous Metabolite	MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮，可通过抑制MEK1和PI3K 来抑制皮肤癌。
T15542	Hypothemycin	Others	Others
	Hypothemycin is a fungal polyketide and is a multikinase inhibitor (Kis: 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively).
T14055	5Z-7-Oxozeaenol FR148083,L783279,LL-Z 1640-2	VEGFR; FLT; MEK; MAPK; PDGFR; Antibiotic; Src	Angiogenesis; MAPK; Microbiology/Virology; Tyrosine Kinase/Adaptors
	5Z-7-Oxozeaenol (FR148083) 是一种天然抗原生动物抑制剂，不可逆的选择性抑制 TAK1和 VEGF-R2，IC50值分别为 8 nM 和 52 nM。
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Notoginsenoside R2

Cat.No: T6S1587

Synonym: 三七皂苷R2,20(S)-Notoginsenoside R2,Ginsenoside Ng-R2

Target: Others, Nrf2

Cat.No: T5S2361

Target: ERK, Beta-Secretase, MEK, BACE, AMPK, AChR, AChE

Cat.No: T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Cat.No: T15542

Target: Others

5Z-7-Oxozeaenol

Cat.No: T14055

Synonym: FR148083,L783279,LL-Z 1640-2

Target: VEGFR, FLT, MEK, MAPK, PDGFR, Antibiotic, Src

Cat.No: T36954

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