54
1
51
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1817 |
GNF-2
GNF2 |
SARS-CoV; Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors |
GNF-2 是一种高选择性的非 ATP 竞争性 Bcr-Abl 抑制剂。 它抑制 Ba/F3.p210 增殖,IC50为 138 nM。 | |||
T2490 |
Osimertinib
AZD-9291,Mereletinib,奥希替尼 |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Osimertinib (AZD-9291) 是一种 EGFR 三代抑制剂,抑制二代 EGFR 抑制剂产生的 T790M 耐药突变,具有不可逆性和口服活性。Osimertinib 具有抗肿瘤活性,用于治疗 EGFR 突变的非小细胞肺癌。 | |||
T9072 |
Tuxobertinib
BDTX-189 |
EGFR; HER; BTK; RIP kinase | Angiogenesis; Apoptosis; JAK/STAT signaling; NF-κB; Tyrosine Kinase/Adaptors |
Tuxobertinib (BDTX-189) 是一种高效可口服的选择性 EGFR 和 HER2变构突变抑制剂,具有抗癌活性。它对 EGFR、HER2、BLK 和 RIPK2 的 KD 值分别为 0.2、0.76、13 和 1.2 nM。 | |||
T3634 |
Osimertinib mesylate
甲磺酸奥希替尼,Mereletinib mesylate,奥希替尼甲磺酸盐,AZD-9291 mesylate |
EGFR | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Osimertinib mesylate (Mereletinib mesylate) 是一种不可逆的突变选择性 EGFR 抑制剂,对EGFRL858R 和EGFRL858R/T790M 的IC50值分别为 12 和 1 nM。 | |||
T36164 |
8-iso Prostaglandin F3α
8-iso Prostaglandin F3α,8-epi PGF3α |
||
8-iso PGF3α is an isoprostane produced from the free-radical peroxidation of EPA. Little is known about the biological activity of 8-iso PGF3α. There is one report that it is inactive in a TP receptor mediated assay of human platelet shape change, where 8-iso PGF2α has an ED50 value of 1 uM. [1] | |||
T13276 |
VAF347
4-(3-氯苯基)-N-[4-(三氟甲基)苯基]嘧啶-2-胺 |
Aryl Hydrocarbon Receptor | Immunology/Inflammation |
VAF347 是细胞可渗透且高度亲和力的芳烃受体激动剂,可诱导AhR 信号传导,具有抗炎作用。它抑制颗粒单核细胞 (GM 期) 前体中 CD14+CD11b+单核细胞的发育。 | |||
T69735 |
ITF3756
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
ITF3756 是一种选择性 HDAC6 抑制剂。 | |||
T3347 |
PF3274167
PF 3274167,Cligosiban,PF-3274167 |
OX Receptor | GPCR/G Protein; Neuroscience |
PF3274167 (Cligosiban) 是一种有效的、选择性的、高亲和力的非肽催产素受体拮抗剂。 | |||
TP1782L |
CEF3 acetate(199727-62-3 free base)
|
Influenza Virus | Microbiology/Virology |
CEF3 acetate(199727-62-3 free base) 对应于甲型流感病毒 M1蛋白的氨基酸13-21。甲型流感病毒的基质 (M1) 蛋白是一种多功能蛋白,在病毒生命周期中发挥重要的结构和功能作用。 | |||
T7399 |
LF3
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
LF3 是一种典型 Wnt 信号传导的特异性抑制剂,通过破坏 β-catenin 和 TCF4 之间的相互作用(IC50 < 2 μM) | |||
T22889 |
KF38789
KF 38789 |
Others | Others |
KF38789 特异性的抑制P-selectin 与PSGL-1结合。它对 U937 细胞与 P-selectin 免疫球蛋白 G 嵌合蛋白 (P-selectin-Ig) 的结合具有抑制作用 (IC50:1.97 μM) 。 | |||
T15410 |
GNF351
|
Aryl Hydrocarbon Receptor | Immunology/Inflammation |
GNF351 是芳烃受体 (AhR) 的完全拮抗剂,具有抑制 DRE 依赖性和非依赖性活性的能力。它与结合到 AhR 的光亲和性 AhR 配体竞争,IC50为 62 nM。它在小鼠或人角质形成细胞中的毒性极小。 | |||
TQ0086 |
AF38469
AF-38469 |
Neurotensin Receptor | GPCR/G Protein |
AF38469 是一种新型、特异性和可口服的Sortilin 抑制剂,IC50值为 330 nM。 | |||
T21907 |
PACOCF3
1,1,1-trifluoroheptadecan-2-one,Palmityltrifluoromethylketone |
Phospholipase | Metabolism |
PACOCF3 (Palmityltrifluoromethylketone) (Palmityltrifluoromethylketone) 是一种钙非依赖性的磷脂酶 A2 (phospholipase A2) 抑制剂,IC50为 3.8 μM。PACOCF3 改变肾小管细胞中的 Ca2+信号传导。 | |||
T4217 |
INF39
|
NOD-like Receptor (NLR); NOD | Immunology/Inflammation; NF-κB |
INF39 是无细胞毒性的NLRP3不可逆抑制剂。 | |||
TP1782 |
CEF3
|
||
CEF3 (SIIPSGPLK) is a peptide representing amino acids 13-21 of the M1 protein in the influenza A virus. The M1 protein is a versatile component of the influenza A virus, carrying out crucial structural and functional tasks throughout the virus's life cycle. | |||
T33953 |
PF3845yne
PF-3845yne,PF 3845yne |
||
PF3845yne is an alkyne analogue of PF-3845 maintaining high potency for FAAH. | |||
T12276 |
NVS-CRF38
|
Others | Others |
NVS-CRF38 is an antagonist of corticotropin-releasing factor receptor 1 (CRF1). | |||
T68334 | AF3442 | ||
AF3442 is a potent and selective mPGES-1 inhibitor (microsomal prostaglandin (PG) E synthase-1). AF3442 caused a concentration-dependent inhibition of PGE(2) in human recombinant mPGES-1 with an IC(50) of 0.06microM. AF3442 is a selective mPGES-1 inhibitor which reduced monocyte PGE(2) generation also in the presence of plasma proteins. Pharmacological inhibition of mPGES-1 did not translate into redirection of PGH(2) metabolism towards other terminal PG synthases in monocytes. The functional re... | |||
T39538 |
BCOT-PEF3-OPFP
BCOT-PEF3-OPFP |
||
BCOT-PEF3-OPFP is a cleavable linker vital in ADC synthesis. BCOT-PEF3-OPFP joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness. | |||
T11446 |
GNF362
|
Others | Others |
GNF362 is a selective and orally bioavailable inhibitor of inositol trisphosphate 3’ kinase B (Itpkb; IC50: 9 nM). GNF362 also inhibits Itpka and Itpkc (IC50s: 20 nM and 19 nM). | |||
T39127 |
meso-CF3-BODIPY 2
CF3-substituted Tetramethyl BODIPY,meso-CF3-BODIPY 2 |
||
meso-CF3-BODIPY 2, also known as CF3-substituted Tetramethyl BODIPY, is a fluorescent dye that has an absorption wavelength (λ abs ) of 553 nm and an emission wavelength (λ em ) of 622 nm. This compound is commonly utilized as a labeling reagent and in photodynamic therapy. | |||
T75358 | DMTr-4'-CF3-5-Me-U-CED phosphoramidite | ||
DMTr-4'-CF3-5-Me-U-CED phosphoramidite (DMTr-4'-CF3-5-Methyluridine-CED phosphoramidite) 为一种修饰寡脱氧核苷酸 (ODN),作为用于寡核苷酸标记的染料试剂,在 RNA 研究领域有其应用价值。 | |||
T22273 |
BI SF3
|
Others | Others |
BI SF3 是合成杂芳基甲酰胺的中间体。 | |||
T65874 |
Fmoc-D-Phe(4-CF3)-OH
|
||
Fmoc-D-Phe(4-CF3)-OH 是一种氨基酸衍生物,在生命科学相关研究中具有广泛的应用。 | |||
T21681 |
AACOCF3
Arachidonyl trifluoromethyl ketone,Arachidonyltrifluoromethane |
Phospholipase | Metabolism |
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid. It is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Moreover, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. Given its diverse applications, AACOCF3 ... | |||
T40239 |
Tenofovir-C3-O-C15-CF3 ammonium
Tenofovir-C3-O-C15-CF3 ammonium |
||
Tenofovir-C3-O-C15-CF3 (ammonium) demonstrates prolonged half-life values compared to tenofovir in human liver microsomes. It exhibits potent anti-HIV activity in vitro and enhances pharmacokinetic properties in vivo. | |||
T82952 | ATF3 inducer 1 | ||
ATF3 inducer 1, 作为一种高效ATF3诱导剂,能显著提高ATF3蛋白及其mRNA的表达水平,并在小鼠模型中展现出对MetS的抗性活性。 | |||
T70922 |
SKF32802
|
||
SKF32802 is a novel potent, selective hERG potassium channel (Kv11.1) activator that induces a leftward shift in the voltage dependence of activation. | |||
T60254 |
Calcium glycerophosphate
|
Phosphorylase | Metabolism |
Calcium glycerophosphate(CaGP)是肠道碱性磷酸酶 F3 的抑制剂 (intestinal alkaline phosphatase F3)。Calcium glycerophosphate 可作为全肠外营养溶液中钙和磷的来源。 | |||
T77372 |
Tisotumab
1E10,1.00E+10 |
Others | Others |
Tisotumab (Anti-Human F3 Recombinant Antibody) 是一种针对组织因子 (TF) 的人 IgG1 单克隆抗体。Tisotumab 参与抗体偶联药物,可用于研究癌症。 | |||
T71857 |
GTP-14564
|
FLT; Tyrosine Kinases | Angiogenesis; Tyrosine Kinase/Adaptors |
GTP-14564是一种新型酪氨酸激酶抑制剂,对 wt-FLT3和ITD-FLT3也具有抑制作用。GTP-14564 在 3μ m 处抑制表达 ITD-FLT3 的白细胞介素-3 非依赖性 Ba/F1 的生长,而需要高 30 倍的 GTP-14564 浓度来抑制表达野生型 FLT3 的 Ba/F3 的 FLT3 配体依赖性生长 (wt-FLT3)。 | |||
T5177 |
Asciminib
ABL001 |
Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Asciminib (ABL001) 是一种有效的、选择性的变构BCR-ABL1抑制剂,能够抑制 Ba/F3 细胞生长 (IC50:0.25 nM)。 | |||
T23450 |
TCS PrP Inhibitor 13
5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One |
Others | Others |
TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) 是一种抗朊病毒剂,可抑制蛋白酶抗性朊病毒蛋白的积累。它诱导神经鞘瘤细胞调亡,在ScN2a 和F3细胞株中均显示IC50值为3 nM。 | |||
T67894 |
Butyzamide
|
Thrombopoietin Receptor; JAK | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Butyzamide 是一种有效的 可口服的Mpl 激活剂,是一种对血小板生成素(TPO)受体具有拮抗作用的新型非肽基分子,促进表达人Mpl (hMpl)的和小鼠pro B 细胞株Ba/F3的增殖,诱导JAK2、STAT3、STAT5和MAPK 的磷酸化。Butyzamide 在小鼠异种移植试验中有助于提升血小板水平。 | |||
T17927 |
(S,R,S)-AHPC TFA
VH032-NH2 TFA,VHL ligand 1 TFA |
Others; Ligand for E3 Ligase | Others; PROTAC |
(S,R,S)-AHPC TFA (VHL ligand 1 TFA) 是一种 VH032-based VHL ligand,可用于募集 von Hippel-Lindau (VHL)蛋白。它能够利用 linker 与靶蛋白配体连接,形成 PROTAC 分子。 | |||
T6097 |
GNF-5837
GNF 5837 |
Trk receptor; PDGFR; c-Kit | Angiogenesis; Tyrosine Kinase/Adaptors |
GNF-5837 是一种选择性的,有效的,口服生物利用的泛TRK 抑制剂,在 Ba/F3 细胞中显示出抗增殖作用 (对Tel-TrkC,Tel-TrkB 和Tel-TrkA 的IC50值分别为 7 nM,9 nM 和 11 nM)。 | |||
T35900 |
JAK2-IN-7
JAK2-IN-7 |
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK2-IN-7 是一种选择性 JAK2抑制剂,对 JAK2,SET-2 和 Ba/F3V617F 细胞的IC50为 3、11.7 和 41 nM。 JAK2-IN-7 的选择性是 JAK1, JAK3,FLT3 的 14 倍以上。JAK2-IN-7 刺激细胞周期停滞在 G0/G1 期,并诱导肿瘤细胞凋亡 (apoptosis),具有抗肿瘤活性。 | |||
T63643 |
BI-4142
|
HER | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
BI-4142 是一种具有口服活性、高效和选择性的 HER2 抑制剂,抑制癌细胞增殖,抑制her2依赖性细胞系并抑制下游信号传导。 | |||
T15480 |
HG6-64-1
HMSL 10017-101-1 |
Others | Others |
HG6-64-1 is a potent and selective inhibitor of B-Raf (IC50: 0.09 μM on B-raf V600E transformed Ba/F3 cells). | |||
T39732 |
BCR-ABL-IN-3
|
||
BCR-ABL-IN-3 is a highly effective and irreversibly binding inhibitor of Bcr-Abl, displaying a remarkable potency with an IC50 value of ≤100 nM for Ba/F3 Bcr-Abl T3151. This compound exhibits significant anti-cancer activity. | |||
T63226 | Asciminib hydrochloride | ||
Asciminib (ABL001) hydrochloride 是选择性的、有效的变构 BCR-ABL1 抑制剂,能够抑制 Ba/F3 细胞生长(IC50: 0.25 nM)。 | |||
T62531 |
TRK-IN-12
|
||
TRK-IN-12 (Compound 9e) 是一种大环衍生的有效TRK抑制剂,具有显著的TRKG595R抑制活性 (IC50= 13.1 nM)。在Ba/F3-LMNA-NTRK1细胞系中具有出色的抗增殖效果 (IC50= 0.080 μM),并且在Ba/F3-LMNA-NTRK1-G595R细胞系中展示了超过对照活性分子LOXO-101的抑制能力 (IC50= 0.646 μM)。 | |||
T83146 |
ALK-IN-27
|
||
ALK-IN-27(化合物1)是一种有效的ALK抑制剂,展现出抗肿瘤活性。在Ba/F3 CLIP1-LTK细胞中,ALK-IN-27的IC50为2.7 nM。 | |||
T67699L |
ALK/ROS1 inhibitor 2e HCL
(R)-1-(2-((2-methoxy-4-(piperazin-1-yl)phenyl)amino)pyridin-4-yl)-N-(4-(trifluoromethoxy)benzyl)piperidine-3-carboxamide hydrochloride(2365497-12-5 Free base) |
Apoptosis | Apoptosis |
ALK/ROS1 inhibitor 2e HCL 具有抗凋亡、抗增殖和抗肿瘤活性。 | |||
T78968 | TRK-IN-23 | Trk receptor | Tyrosine Kinase/Adaptors |
TRK-IN-23 (compound 24b) 是一款口服活性TRK抑制剂,对TRKA、TRKC、TRKAG595R、TRKAF589L和TRKAG667C 表现出高效的抑制作用,其IC50值分别为0.5 nM、9 nM、14 nM、4.4 nM和4.8 nM。此外,TRK-IN-23 能够诱导含有TRKAG595R和TRKAG667C突变的Ba/F3细胞系进行细胞凋亡(apoptosis)。 | |||
T39896 |
ALK-IN-9
|
||
ALK-IN-9 (compound 40) is a highly effective ALK inhibitor. It demonstrates remarkable inhibitory activity against cell proliferation, with IC50 values of <0.2 nM for Ba/F3-EML4-ALK, KM 12 (TPM3-TRKA), and KG-l cell (OP2-FGFR1). | |||
T79420 |
FLT3-IN-22
|
||
FLT3-IN-22(化合物22f)是一款高效的FLT3抑制剂,具有针对FLT3和FLT3/D835Y极低的IC50值,分别为0.941 nM和0.199 nM。在MV4-11细胞和携带FLT3变异的Ba/F3细胞系中(涵盖FLT3-D835Y及FLT3-F691L),此抑制剂显示出显著的抗增殖能力。 | |||
T63932 |
BCR-ABL-IN-4
|
||
BCR-ABL-IN-4 是 BCR-ABLL 抑制剂,表现出抗癌活性。BCR-ABL-IN-4 对癌细胞生长具有抑制作用,能够作用于 K562 细胞 (IC50: 0.67 nM) 和 BCR-ABL T315I 转染的 Ba/F3 细胞 (IC50: 16 nM)。 | |||
T72289 | Type II TRK inhibitor 1 | Trk receptor | Tyrosine Kinase/Adaptors |
Type II TRK inhibitor 1 是有效抑制多种TRK融合蛋白及野生型的TRK抑制剂。对携有CD74-TRKAG667C及ETV6-TRKCG696C融合蛋白的Ba/F3细胞表现出抗增殖活性,其IC50值分别为6 nM与1.7 nM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3829 |
Ginsenoside F3
人参皂苷F3 |
Others; IFNAR; Interleukin | Immunology/Inflammation; Others |
Ginsenoside F3 是一种皂苷,提取自Panax ginseng 叶片。它能够调节1 型 (IL-2, IFN-γ) 及 2 型细胞因子(IL-4 and IL-10) 的产生和表达,有免疫增强的作用。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00720 |
Contactin 1 Protein, Human, Recombinant (His)
contactin 1,F3,GP135,MYPCN |
Human | HEK293 |
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3 (BIG-1), BIG-2, Contactin-5 (NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function o... | |||
TMPY-03295 |
Transferrin Protein, Mouse, Recombinant (His)
transferrin,F3,Cf3,Cf-3 |
Mouse | HEK293 |
Transferrin is a glycoprotein with an approximate molecular weight of 76.5 kDa. This glycoprotein is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of Transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as g... | |||
TMPY-03294 |
Transferrin Protein, Mouse, Recombinant (hFc)
transferrin,Cf3,Cf-3,F3 |
Mouse | HEK293 |
Transferrin is a glycoprotein with an approximate molecular weight of 76.5 kDa. This glycoprotein is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of Transferrin is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as g... | |||
TMPK-00993 |
Coagulation Factor III/Tissue Factor Protein, Canine, Recombinant (His)
Thromboplastin,CD142,TF,FLJ17960,TFA,F3,Coagulation... |
Canine | HEK293 |
Tissue factor (also named Coagulation Factor III) is a cell surface glycoprotein responsible for initiating the extrinsic pathway of coagulation.Tissue factor is the primary cellular initiator of blood coagulation via interaction with coagulation factor VII. Aberrant expression of tissue factor is responsible for thrombosis during septic shock, atherosclerosis and cancer. | |||
TMPH-03054 |
Asp f3 Protein, Neosartorya fumigata, Recombinant (His & SUMO)
|
Neosartorya fumigata | E. coli |
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Required for virulence. | |||
TMPY-02312 |
CSF3R/G-CSFR Protein, Human, Recombinant (His)
CSF3R,GCSFR,colony stimulating factor 3 receptor (g... |
Human | HEK293 |
Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor l... | |||
TMPY-03796 |
ARF3 Protein, Human, Recombinant (His)
ADP-ribosylation factor 3 |
Human | E. coli |
ARF3, also known as ADP-ribosylation factor 3, belongs to the RAS superfamily. Members of this family include ARF1, ARF2, ARF3, ARF4, ARF5 and ARF6. ARF3 gene is a member of the human ARF gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. ARF3 functions as an allosteric activator of the cholera toxin subunit, an ADP-ribosyltrans... | |||
TMPY-00814 |
CSF3R/G-CSFR Protein, Human, Recombinant (hFc)
G-CSF R,GCSFR,CD114,CSF3R,colony stimulating factor... |
Human | HEK293 |
Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor l... | |||
TMPH-01129 |
C1QTNF3 Protein, Human, Recombinant (His)
C1QTNF3,CORS26,Collagenous repeat-containing sequen... |
Human | E. coli |
C1QTNF3 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-01310 |
EIF3G Protein, Human, Recombinant (His & SUMO)
eIF3 p42,eIF-3-delta,eIF3 p44,eIF3 |
Human | E. coli |
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for di... | |||
TMPH-02734 |
IRF3 Protein, Mouse, Recombinant (His & Myc)
|
Mouse | Yeast |
IRF3 Protein, Mouse, Recombinant (His & Myc) is expressed in Yeast. | |||
TMPY-03751 |
C1orf33/MRTO4 Protein, Human, Recombinant (His)
MRT4,dJ657E11.4,C1orf33,MRT4 homolog, ribosome matu... |
Human | E. coli |
MRTO4 (MRT4 Homolog, Ribosome Maturation Factor) is a Protein Coding gene. MRTO4, also known as MRT4, belongs to the universal ribosomal protein uL10 family. This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. MRTO4 is a nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. The precise function of MRTO4 is c... | |||
TMPJ-01173 |
TFF3 Protein, Mouse, Recombinant (His)
Itf,Trefoil factor 3,Intestinal trefoil factor,mITF,Tff3... |
Mouse | Human Cells |
Trefoil factors (TFF) are secretory products of mucin producing cells. They play a key role in the maintenance of the surface integrity of oral mucosa and enhance healing of the gastrointestinal mucosa by a process called restitution. TFF comprises the gastric peptides (TFF1), spasmolytic peptide (TFF2), and the intestinal trefoil factor (TFF3). They have an important and necessary role in epithelial restitution within the gastrointestinal tract. Members of the trefoil family are characterized b... | |||
TMPY-03451 |
SPF30 Protein, Human, Recombinant (His)
SPF30,SMNR,TDRD16C,survival motor neuron domain con... |
Human | E. coli |
SMNDC1 gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. SMNDC1 is a nuclear protein that has been identified as a constituent of the spliceosome complex. SMNDC1 gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. SMNDC1 is necessary for spliceosome assembly. Its overexpression causes apoptosis. | |||
TMPH-01309 |
EIF3F Protein, Human, Recombinant (His)
eIF3 p47,eIF-3-epsilon,EIF3S5,eIF3 |
Human | E. coli |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an... | |||
TMPH-01275 |
ZNRF3 Protein, Human, Recombinant (His)
|
Human | HEK293 |
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs ... | |||
TMPH-00502 |
TFF3 Protein, Canine, Recombinant (His & Myc)
|
Canine | E. coli |
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). | |||
TMPY-05973 |
SARS-CoV-2 Spike RBD Protein (F377L, His)
|
SARS-CoV-2 | HEK293 |
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of... | |||
TMPY-03343 |
EIF3K Protein, Human, Recombinant (His & GST)
PRO1474,eukaryotic translation initiation factor 3, subunit ... |
Human | Baculovirus-Insect Cells |
EIF3K is a member of the eIF3 subunit K family. It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 4S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). It stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. EIF3K i... | |||
TMPY-02243 |
IGSF3 Protein, Human, Recombinant (His)
LCDD,immunoglobulin superfamily, member 3,EWI-3,V8 |
Human | HEK293 |
Immunoglobulin superfamily member 3 (IGSF3), also known as Glu-Trp-Ile EWI motif-containing protein 3, IgSF3 and EWI-3 and IGSF3, is a single-pass type I membrane protein that belongs to the EWI subfamily of the Ig superfamily of molecules. IGSF3 has an overall structural similarity and strong sequence similarity to V7, a human leukocyte surface protein. IGSF3 contains eight Ig-like C2-type (immunoglobulin-like) domains. IGSF3 is expressed in a wide range of tissues with high expression in the p... | |||
TMPY-04828 |
TFF3 Protein, Human, Recombinant (His)
trefoil factor 3 (intestinal),ITF,P1B,TFI |
Human | HEK293 |
Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Trefoil factor-3 (TFF3) is an estrogen-regulated gene associated with prognosis in different types of cancer. The presence and localization of TFF3 peptide was associated with the embryonic stage and tissue differentiation. TFF3 peptide distribution specific to the germ layers was not observed. The role of TFF3 peptide in cell migration and differentiation, immune response, an... | |||
TMPJ-00359 |
SLAMF3 Protein, Human, Recombinant (His)
Signaling lymphocytic activation molecule 3,CD229,Cell surfa... |
Human | Human Cells |
SLAMF3 (CD229) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature human SLAMF3 consists of a 407 amino acid (aa) extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains. The ECD of human SLAMF3 shares 57% - 59% aa sequence identity with mouse and rat SLAMF3. Within the first two Ig-like domains that are common to all SLAM proteins, human SLAMF3 shares 24% - 39% aa sequence identity with human 2B4, BLAME, CD2F-10, CD84, CRACC, ... | |||
TMPH-02207 |
TRAF3 Protein, Human, Recombinant (His)
|
Human | E. coli |
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein liga... | |||
TMPH-02086 |
SRSF3 Protein, Human, Recombinant (GB1 & His)
|
Human | E. coli |
SRSF3 Protein, Human, Recombinant (GB1 & His) is expressed in E. coli. | |||
TMPH-03288 |
EIF3I Protein, Rat, Recombinant (His)
eIF3i,Eif3s2,eIF-3-beta,Eukaryotic transla... |
Rat | Baculovirus |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an... | |||
TMPH-01130 |
C1QTNF3 Protein, Human, Recombinant (His & Myc)
Secretory protein CORS26,Collagenous repeat-containing seque... |
Human | Baculovirus |
C1QTNF3 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus. | |||
TMPH-02243 |
TFF3 Protein, Human, Recombinant (GST)
|
Human | E. coli |
Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen). | |||
TMPH-01274 |
ZNRF3 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs ... | |||
TMPH-00303 |
SF3B3 Protein, Bovine, Recombinant (His)
|
Bovine | E. coli |
Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, whic... | |||
TMPJ-01154 |
SLAMF3 Protein, Mouse, Recombinant (His)
SLAM family member 3,T-lymphocyte surface antigen Ly-9,Ly-9,... |
Mouse | Human Cells |
CD229(SLAMF3) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature mouse CD229 consists of a 406 aa extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains, a 21 aa transmembrane segment, and a 180 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs ITSMs. Within the first two Ig-like domains that are common to all SLAM proteins, mouse CD229 shares 22%-36% aa sequence identity with mouse 2B4, BLAME, CD2F10,... | |||
TMPH-00539 |
Epstein-Barr virus (strain B95-8) BDLF3 Protein (His & Myc)
|
EBV | E. coli |
Epstein-Barr virus (strain B95-8) BDLF3 Protein (His & Myc) is expressed in E. coli. | |||
TMPH-02208 |
TRAF3 Protein, Human, Recombinant
|
Human | E. coli |
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein liga... | |||
TMPH-02598 |
C1QTNF3 Protein, Mouse, Recombinant (His)
Secretory protein CORS26,C1QTNF3,Complement C1q tum... |
Mouse | HEK293 |
C1QTNF3 Protein, Mouse, Recombinant (His) is expressed in HEK293 with N-terminal 10xHis tag. The predicted molecular weight is 26.6 kDa. Accession number: Q9ES30 | |||
TMPY-05972 |
SARS-CoV-2 Spike RBD Protein (F338L, His)
|
SARS-CoV-2 | HEK293 |
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of... | |||
TMPH-02977 |
ZNF346 Protein, Mouse, Recombinant (His & SUMO)
|
Mouse | E. coli |
Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. May bind to specific miRNA hairpins. | |||
TMPH-03289 |
EIF3I Protein, Rat, Recombinant (E. coli, His)
eIF3 p36,eIF3i,eIF-3-beta,Eukaryotic trans... |
Rat | E. coli |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an... | |||
TMPH-00812 |
Hepatitis E virus genotype 1 (HEV-1) Protein ORF3 (His & SUMO)
|
HEV-1 | E. coli |
Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. Acts also as a viroporin and forms ion conductive pores allowing viral particle release. Impairs the generation of type I interferon by downregulating host TLR3 and TLR7 as well as their downstream signaling pathways. | |||
TMPH-01311 |
EIF3M Protein, Human, Recombinant (His & SUMO)
HFLB5,eIF3m,EIF3M,hFL-B5,Eukaryotic transl... |
Human | E. coli |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an... | |||
TMPY-05704 |
SARS-CoV-2 Spike RBD Protein (F342L, His)
|
SARS-CoV-2 | HEK293 |
The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of... | |||
TMPY-01862 |
IL-4 Protein, Human, Recombinant
Interleukin-4,IL-4,BCGF1,白细胞介素,interleukin 4,BSF1,BSF-1,BCGF... |
Human | E. coli |
Interleukin-4, also known as IL4, is a secreted protein that belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 / IL4 also regulates the expression of the low-affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody producti... | |||
TMPY-05094 |
Tissue Factor Protein, Cynomolgus, Recombinant (His)
coagulation factor III (thromboplastin, tissue factor) |
Cynomolgus | HEK293 |
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating... | |||
TMPY-02530 |
Tissue Factor Protein, Human, Recombinant (His)
CD142,coagulation factor III (thromboplastin, tissue factor)... |
Human | HEK293 |
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating... | |||
TMPY-02790 |
IL-4 Protein, Canine, Recombinant
白介素,interleukin 4,白细胞介素 |
Canine | E. coli |
Interleukin-4, also known as IL4, is a secreted protein that belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 / IL4 also regulates the expression of the low-affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody producti... | |||
TMPY-03624 |
IL-4 Protein, Mouse, Recombinant (Q136D, Y139D, His)
interleukin 4,白细胞介素,BSF-1,Il-4,白介素 |
Mouse | Baculovirus-Insect Cells |
Interleukin-4, also known as IL4, is a secreted protein that belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 / IL4 also regulates the expression of the low-affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody producti... | |||
TMPH-01241 |
TOP1 Protein, Human, Recombinant (His & Myc)
|
Human | Baculovirus |
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates a... | |||
TMPY-02537 |
Tissue Factor Protein, Human, Recombinant (hFc)
coagulation factor III,coagulation factor III (thromboplasti... |
Human | HEK293 |
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating... | |||
TMPY-01325 |
Tissue Factor Protein, Mouse, Recombinant (His)
Cf-3,AA409063,CD142,coagulation factor III (thromboplastin, ... |
Mouse | HEK293 |
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating... | |||
TMPY-05083 |
Tissue Factor Protein, Human, Recombinant (aa 1-295, His)
coagulation factor 3,TF,TFA,coagulation factor III,coagulati... |
Human | Baculovirus-Insect Cells |
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating... | |||
TMPY-02318 |
Tissue Factor Protein, Rabbit, Recombinant (His)
coagulation factor III (thromboplastin, tissue factor) |
Rabbit | HEK293 |
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating... | |||
TMPY-06957 |
Tissue Factor Protein, Human, Recombinant (hFc & Avi), Biotinylated
TFA,coagulation factor 3,coagulation factor III,CD142,coagul... |
Human | HEK293 |
Tissue factor (TF), also known as coagulation factor III, F3, and CD142, is a single-pass type I membrane protein which belongs to the tissue factor family. Tissue factor is one of the proteins that participate in hemostatic and inflammatory processes. Activated monocytes present in the liver increase expression of tissue factor, and while accumulating in the organ they can intensify inflammation. Tissue factor is the protein that activates the blood clotting system by binding to, and activating... | |||
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