69
16
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22260 |
Aminopurvalanol A
|
CDK | Cell Cycle/Checkpoint |
Aminopurvalanol A 是一种竞争性、选择性和细胞渗透性的Cyclins/Cdk 复合物抑制剂,优先靶向G2/M 期转变进而抑制癌细胞分化。它通过抑制生理获能依赖性肌动蛋白聚合而抑制精子受精能力。 | |||
T13410 |
ZLDI-8
|
Apoptosis; Phosphatase; Gamma-secretase; Immunology/Inflammation related | Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience; Proteases/Proteasome; Stem Cells |
ZLDI-8 是 Notch 激活/裂解酶 ADAM-17 的抑制剂,可抑制 Notch 蛋白裂解,并降低促存活/抗凋亡和上皮-间质转化相关蛋白的表达。它还是竞争性不可逆酪氨酸磷酸酶抑制剂,以IC50为 5.32 μM 抑制 MHCC97-H 细胞的生长。 | |||
T21981 |
Phthalazinone pyrazole
|
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
Phthalazinone pyrazole 是强效、选择性和口服生物可利用的 Aurora-A 激酶抑制剂,IC50值为 0.031 μM。它抑制人胚胎干细胞向肝细胞样细胞分化过程中的上皮间质转化。它还可阻止有丝分裂并随后通过增殖细胞的凋亡抑制肿瘤生长。 | |||
T0459 |
Sulindac
Arthrocine,MK-231,舒林酸,Clinoril,Sulindac sulfoxide |
COX; Autophagy | Autophagy; Immunology/Inflammation; Neuroscience |
Sulindac (Sulindac sulfoxide) 是一种非甾体类抗炎剂,可抑制COX-2的活性,也可抑制 COX-2 的过表达。它是一种亚磺酰基茚衍生物前药,具有潜在的抗肿瘤活性。 | |||
T1725 |
Y-27632 dihydrochloride
反式-4-[(R)-1-氨基乙基]-N-(4-吡啶基)环己烷甲酰胺二盐酸盐,Y-27632 2HCl |
ROCK; Apoptosis | Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
Y-27632 dihydrochloride (Y-27632 2HCl) 是一种 ROCK-I 和 ROCK-II 抑制剂,具有口服有效性、ATP 竞争性。Y-27632 dihydrochloride 还抑制分离诱导的小鼠前列腺干或祖细胞凋亡。 | |||
T37890L |
GLP-1(28-36)amide acetate
GLP-1(28-36)amide acetate(1225021-13-5 Free base) |
Antioxidant; Glucagon Receptor | GPCR/G Protein; oxidation-reduction |
GLP-1(28-36)amide acetate 抑制线粒体通透性转变,具有抗氧化、抗糖尿病和心脏保护活性。 | |||
T21339 |
Peramivir
RWJ 270201,BCX1812,BCX 1812,帕拉米韦,RWJ270201 |
||
Peramivir, a neuraminidase inhibitor, acts as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. It is used as an antiviral drug for the treatment of influenza. | |||
T22402 |
Potassium thioacetate
|
Others | Others |
Potassium thioacetate 它已被用于合成聚合物、杂环、纳米颗粒、过渡金属配体、生物活性化合物和大分子包合物。 | |||
T7486 |
Imeglimin hydrochloride
EMD 387008 hydrochloride,(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐 |
Reactive Oxygen Species; Mitochondrial Metabolism | Immunology/Inflammation; Metabolism; NF-κB |
Imeglimin hydrochloride (EMD 387008 hydrochloride) 是一种口服降糖剂。Imeglimin 可改善胰岛素敏感性,能够抑制活性氧的产生、增加线粒体 DNA、改善线粒体功能。 | |||
T15241 |
ER-000444793
|
Others; Mitochondrial Metabolism | Metabolism; Others |
ER-000444793 是一种线粒体通透性转换孔开放抑制剂。它能够抑制 mPTP,IC50=2.8 μM。 | |||
T10404 |
ATP synthase inhibitor 1
|
ATPase | Membrane transporter/Ion channel |
ATP synthase inhibitor 1 是 F1/FO-ATP 合酶复合物 c 亚基的有效抑制剂,抑制线粒体通透性转换孔的开放。 | |||
T4252 |
ML327
|
c-Myc; Autophagy | Autophagy; Cell Cycle/Checkpoint |
ML327 是 MYC 的阻断剂,还可抑制 E-钙粘蛋白转录和逆转上皮间质转化。 | |||
T9601 | Tepotinib hydrochloride(1 : x) | c-Met/HGFR; P-gp; ABC | Membrane transporter/Ion channel; Neuroscience; Tyrosine Kinase/Adaptors |
Tepotinib hydrochloride(1 : x) 是一种口服生物可利用的间充质-上皮转化 (MET) TKI,主要针对具有 METex14 跳跃突变的特定 NSCLC 患者开发。 | |||
T21481 |
Bromophenol Blue
|
Others | Others |
Bromophenol blue 是酸性酞菁染料,可用作电泳的示踪染料。它也是一种 pH 指示剂,pH 指示范围是 3 到 4.6 之间。 | |||
T20346 |
Salicylaldoxime
|
Others | Others |
Salicylaldoxime 是一种螯合剂,有时用于分析含有过渡金属离子的样品,它通常与过渡金属离子形成色彩鲜艳的配位络合物。 | |||
T12593 |
Pyrithione
1-hydroxyl-1H-pyridine-2-thione,吡啶硫酮 |
Others | Others |
Pyrithione (1-hydroxyl-1H-pyridine-2-thione) 是一种锌离子载体,过渡金属配合物,可引起哺乳动物细胞内锌水平的升高,有杀菌和抗真菌作用。 | |||
T2169 |
Zebularine
NSC309132,4-Deoxyuridine |
DNA Methyltransferase; Autophagy | Autophagy; Chromatin/Epigenetic |
Zebularine (4-Deoxyuridine) 是一种 DNA 甲基化抑制剂,还抑制胞苷脱氨酶。它通过以共价水合物的形式与活性大小结合,充当胞苷脱氨酶的过渡态类似物抑制剂。 | |||
T13102 |
TCMDC-135051
|
Others | Others |
TCMDC-135051 是一种高选择性和有效性的蛋白激酶 PfCLK3 抑制剂,具有低的靶外毒性。TCMDC-135051 可以防止滋养体到裂殖体的转变,破坏转录并减少向蚊子载体的传播。TCMDC-135051 具有抗寄生虫活性 (EC50=320 nM)。 | |||
T73300 |
AXL-IN-13
|
FLT; TAM Receptor; PDGFR; TGF-beta/Smad | Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors |
AXL-IN-13 是一种有效且具有口服活性的 AXL 抑制剂 ,其IC50值为 1.6 nM,Kd 值为0.26 nM。AXL-IN-13 具有抗癌活性,可逆转 TGF-β1 诱导的上皮间质转化 (EMT),并抑制癌细胞迁移和侵袭。 | |||
T4321 |
Indisulam
E 7070 |
CDK; Carbonic Anhydrase | Cell Cycle/Checkpoint; Metabolism |
Indisulam (E 7070) 是碳酸酐酶抑制剂。它是细胞周期 G1期的靶向化合物,能够抑制 CDK2及周期蛋白 E 的激活,阻止 G1/S 的转化。它可以募集 DCAF15诱导RBM39降解来靶向剪接,具有抗癌作用。 | |||
T38752 |
EW-7195
|
ALK; TGF-beta/Smad | Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors |
EW-7195 是一种具有选择性和高效性的 ALK5 (TGFβR1) 抑制剂,IC50 值为 4.83 nM。EW-7195 对 ALK5 的亲和力是 p38α 的 300 多倍。EW-7195 对 TGF-β1 诱导的 Smad 信号转导、上皮间质转化 (EMT) 和乳腺癌向肺转移有抑制作用。 | |||
T77701 |
FL118
FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin |
Survivin | Apoptosis |
FL118是一种新型存活素抑制剂,可抑制癌症干细胞样特性。FL118 是一种新型喜树碱类似物,具有抗癌活性,通过 Wnt/β-catenin 信号通路抑制上皮-间充质转化,从而抑制人乳腺癌细胞的迁移和侵袭。 | |||
T11793 |
KY-05009
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
KY-05009 是 ATP 竞争性的、有效的 TNIK 抑制剂,Ki 为 100 nM。KY-05009抑制人肺腺癌细胞中 TGF-β1 诱导的上皮-间质转化。KY-05009 还抑制TNIK 的蛋白表达和Wnt 靶基因的转录活性,并诱导癌细胞凋亡,显示抗癌活性。 | |||
T36696 |
DMBA
|
||
7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzymes, including the cytochrome P450 (CYP450) isoform CYP1B1, as well as microsomal epoxide hydrolase (mEH), producing a variety of reactive metabolites that form DNA adductsin vivo, and it has been commonly used to induce tumor formation in various rodent models.2,3,1DMBA increase... | |||
T34627 |
SFO
Safrole epoxide,Safrole oxide |
||
SFO is an endothelial-to-mesenchymal transition (EndoMT) inducer. | |||
T23776 |
BBMP
|
||
BBMP is an inhibitor of mitochondrial permeability transition pore. | |||
T27426 |
GNX-865
|
||
GNX-865 is an inhibitor of mitochondrial permeability transition pore (mtPTP). | |||
T30681 |
CABP
2-CABP,2CABP,2 CABP |
||
CABP is a transition analog of ribulos-1, 5-diphosphate carboxylase/oxygenase (Rubisco). | |||
T71195 |
mPTP-IN-22
|
||
mPTP-IN-22 is a novel mitochondrial permeability transition pore (mptp) inhibitor | |||
T24485 |
ML404
ML-404,ML 404 |
||
ML404 is the mitochondrial permeability transition pore inhibitor. | |||
T27139 |
Decylubiquinone
|
||
Decylubiquinone is an analog of ubiquinone. It increases mitochondrial function in synaptosomes. Decylubiquinone inhibits the redox-activated mitochondrial permeability transition. | |||
T19386 |
ITIC
|
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
ITIC, a non-fullerene acceptor, demonstrates exceptional thermal stability and exhibits a glass-crystal transition at a significantly lower temperature than its high glass transition temperature (Tg) of 180 °C. Furthermore, ITIC, which is an indacenodithienothiophene-based postfullerene electron acceptor, displays a distinct crystallization behavior, differing substantially from that of fullerenes. | |||
T12226 |
NIM811
SDZ NIM811,(Melle-4)cyclosporin |
Others | Others |
NIM811 is an orally bioavailable dual inhibitor of mitochondrial permeability transition and cyclophilin. | |||
T70543 |
U 92163
|
||
U 92163 is synthetic peptidic transition state analog inhibitor that was used to determine the crystallographic structure of the protease from human immunodeficiency virus type 2. | |||
T33380 |
MI-389
|
||
MI-389 is a protein degrader, targeting the translation termination factor G1 to S phase transition 1 (GSPT1). | |||
T25896 |
Octicidine
ASOHO |
||
Octicidine is derived from phaseolotoxin by the removal of C-terminal dipeptide. It is a transition state analog that irreversibly suppresses ornithine carbamoyltransferase. | |||
T11187 | EMT inhibitor-2 | Others | Others |
EMT inhibitor-2 inhibits CYP3A4 testosteron and CYP2C9 with IC50s of 49.72 and 5.54 μM, respectively. EMT inhibitor-2 inhibits epithelial-mesenchymal transition (EMT) induced by substances such as IL-1β and TGF-β released from the immunocytes. | |||
T79789 |
DT-6
|
TGF-beta/Smad | Stem Cells |
DT-6为一有效TGF-β1抑制剂,能够抑制M2巨噬细胞诱导的上皮至间质转化(Epithelial-Mesenchymal Transition, EMT)及癌细胞侵袭性迁移,可用于癌症相关疾病研究。 | |||
T30477 |
Bis-PEG5-thiol
|
||
Bis-PEG5-thiol is a PEG derivative containing two thiol groups. The thiol groups react with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The hydrophilic PEG spacer increases solubility in aqueous media. | |||
T35703 |
2-hydroxy Stearic Acid methyl ester
|
||
2-hydroxy Stearic acid is a hydroxylated fatty acid methyl ester that broadens phase transition in dimyristoylphosphatidylcholine (DMPC) lipid membranes. It has been used in the synthesis of lipid-nucleotide conjugate anti-HIV agents to increase phosphodiester bond cleavage and the amount of liberated intracellular nucleotides. | |||
T76994 | Sotevtamab | ||
Sotevtamab (16B5) 是一种抗clusterin 单克隆抗体 (mAb)。Sotevtamab 是上皮间充质转化的抑制剂。Sotevtamab 可用于癌症研究。 | |||
T72880 |
PI3K/AKT-IN-2
|
||
PI3K/AKT-IN-2 是一种 PI3K 和 AKT 抑制剂。PI3K/AKT-IN-2 阻断上皮-间质转化 (EMT),诱导细胞凋亡 (apoptosis)。PI3K/AKT-IN-2 抑制微管蛋白 (tubulin) 的聚合。 | |||
T83075 | Anticancer agent 94 | ||
Anticanceragent 94, 一种4-羟基香豆素衍生物,能抑制肺癌细胞的侵袭和迁移,其机制为调节(EMT)效应子表达。 | |||
T83076 |
Anticancer agent 93
|
||
Anticanceragent 93, 一种4-羟基香豆素衍生物,能够抑制肺癌细胞的侵袭与迁移,其机制为调节上皮间质转化(EMT)效应子的表达。 | |||
T37890 |
GLP-1(28-36)amide
|
||
GLP-1(28-36)amide, a C-terminal nonapeptide derived from the cleavage of GLP-1 by neutral endopeptidase (NEP), is a significant product. It functions as an antioxidant and primarily targets the mitochondrion, where it effectively inhibits mitochondrial permeability transition (MPT). This compound exhibits anti-diabetic properties and demonstrates cardioprotection effects[1]. | |||
T71953 |
Thiol-PEG2-acid
|
||
Thiol-PEG2-acid is a PEG derivative containing a thiol group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. | |||
T79474 |
GSPT1 degrader-1
|
Apoptosis | Apoptosis |
GSPT1 degrader-1 (compound 9q) 是通过泛素蛋白酶体系统有效实现 G1 至 S 相变 1 (GSPT1) 降解的化合物。此外,该化合物能诱导G0/G1 期细胞停滞及细胞凋亡 (apoptosis)。 | |||
T80215 |
BMAP-28
|
Antibiotic | Microbiology/Virology |
BMAP-28为一种抗生肽兼具线粒体透性转换孔(inducing agent)功能,能够触发线粒体的透性转换孔(opening),进而诱导细胞凋亡。该化合物在微生物感染及癌症研究领域具有潜在应用价值。 | |||
T69297 | Leupeptin HCl | ||
Leupeptin is a naturally occurring protease inhibitor that can inhibit cysteine, serine and threonine peptidases. Leupeptin is an organic compound produced by actinomycetes. Leupeptin inhibits serine proteinases (trypsin (Ki=3.5 nM), plasmin (Ki= 3.4 nM), porcine kallikrein), and cysteine proteinases (papain, cathepsin B (Ki = 4.1 nM), endoproteinase Lys-C). It does not inhibit α-chymotrypsin or thrombin. Leupeptin is a competitive transition state inhibitor and its inhibition may be relieved by... | |||
T82673 |
CPF-7
Caerulein precursor fragment |
||
CPF-7(Caerulein precursor fragment)是一种促进胰岛素释放的肽,可以通过增加PANC-1导管细胞中Snai1表达来引导上皮-间质转换(EMT),并且CPF-7还能通过提高Ngn3表达以诱导外分泌细胞可塑性。此外,CPF-7适用于2型糖尿病的相关研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3862 |
Irigenin
|
NF-κB; Integrin | Cytoskeletal Signaling; NF-κB |
Irigenin 可通过特异性和选择性地阻断 Extra Domain A 域的 C-C 环上α9β1和α4β1整合素结合位点,介导其抗转移作用。可通过增强胃癌细胞中促凋亡分子的表达来敏化 TRAIL 诱导的凋亡,具有抗癌作用。 | |||
T0518 |
Methacycline hydrochloride
Rondomycin,盐酸甲烯土霉素,盐酸美他环素,Methacycline HCl |
ribosome; Antibacterial; Antibiotic | Microbiology/Virology |
Methacycline hydrochloride (Rondomycin) 是四环素抗生素,可抑制细菌蛋白质的合成。它是上皮-间质转化 (EMT) 抑制剂。它在体外可阻断 EMT,体内抑制纤维发生,不会直接影响 TGF-β1 Smad 信号传导。它是抗菌剂,有潜力研究肺纤维化。 | |||
TN1198 |
19-Hydroxybufalin
|
Others | Others |
19-Hydroxybufalin 是蟾二烯羟酸内酯,能够阻碍上皮间质转化,抑制 PC3 细胞的迁移和侵袭。 | |||
T2S0690 |
Ecliptasaponin A
早莲苷 A,旱莲苷A,Echinocystic acid-3-o-glucoside |
Others | Others |
Ecliptasaponin A (Echinocystic acid-3-o-glucoside) 是一种墨旱莲 (Eclipta prostrate) 中分离得到的五环三萜皂苷。其中墨旱莲是一种具有多效作用的滋补草药,如抗炎、保肝、抗氧化和免疫调节。 | |||
T3330 |
trans-Trimethoxyresveratrol
trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,白藜芦醇三甲醚,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
trans-Trimethoxyresveratrol (MR-3) 是一种 Resveratrol(RSV) 的衍生物,与Resveratrol(RSV)相比,它可能是一个更有效的抗炎、抗血管新生的化合物。 | |||
T8181 |
Poricoic acid A
Poricoic acid A(F),茯苓新酸 A |
Others | Others |
Poricoic acid A (Poricoic acid A(F)) 是提取于 Poria cocos 中,拥有抗肿瘤作用。它通过调节Gas6/AxlNFκB/Nrf2 轴提高AKI-to-CKD 的褪黑激素抑制。 | |||
T7982 |
3,6-Dihydroxyflavone
|
Others | Others |
3,6-Dihydroxyflavone 是一种抗癌剂。它能够提高细胞内氧化应激和脂质过氧化。它是能够根据剂量和时间依赖性地降低细胞活力,并活化半胱天冬酶级联、切割聚 (ADP-核糖) 聚合酶 (PARP) 诱导细胞凋亡。 | |||
TN1003 |
DL-Alanine
DL-2-Aminopropionic acid |
Endogenous Metabolite | Metabolism |
DL-Alanine (DL-2-Aminopropionic acid) 是一种氨基酸,是L-和D-丙氨酸的外消旋化合物。DL-Alanine 与硝酸银水溶液一起用于纳米颗粒生成时常作为还原剂和封端剂。DL-Alanine 是一种甜味剂,可把它位与甘氨酸和糖精钠归为一类。DL-Alanine 在组织和肝脏之间的葡萄糖-丙氨酸循环中起重要作用。DL-Alanine 可用于研究 Cu、Zn、Cd 等过渡金属螯合。 | |||
TN1433 | Batatasin III | FAK; Others; Akt | Angiogenesis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Batatasin III 通过抑制上皮间质转化和 FAK-AKT 信号来抑制癌症迁移和侵袭,并具有抗癌活性。 Batatasin III 对整株生长有长期抑制作用,显示出抑制萌发活性。 | |||
T4S1383 |
Escin IA
Aescin IA,Escin IA;Aescin IA,Escin IA |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Escin IA (Escin IA;Aescin IA);Aescin IA 是从马蹄中七叶树分离出的一种三萜皂苷,抑制HIV-1蛋白酶,IC50值为 35 μM。它具有抗 TNBC 转移活性,其作用机制涉及通过下调 LOXL2 表达抑制上皮-间质转化过程。 | |||
T14140 |
Agaric acid
落叶松蕈酸,Agaricinic Acid |
Mitochondrial Metabolism; AChR | Metabolism; Neuroscience |
Agaric acid (Agaricinic Acid) 来一种自真菌部落的Polyporus officinalis 和Polyporus igniarius。它可促进积累的 Ca2+流出,跨膜电位的破坏和线粒体肿胀。它通过其与腺嘌呤核苷酸转位酶的相互作用诱导线粒体通透性转变。它用于调节脂类代谢。 | |||
T6S1315 |
Oroxylin A
千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy | Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。 | |||
T6S1487 |
Ginsenoside Rg5
人参皂苷Rg5,人参皂甙 Rg5 |
NF-κB; COX; IGF-1R | Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors |
Ginsenoside Rg5 是红参的主要成分,可阻断IGF-1与其受体的结合,IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压,具有抗炎和治疗阿尔茨海默病的潜力。 | |||
TN5336 |
9-Oxo-10,11-dehydroageraphorone
4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone,泽兰二酮 |
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9-Oxo-10,11-dehydroageraphorone has acaricidal activity. It induces hepatotoxicity and cholestasis in rats. 9-Oxo-10,11-dehydroageraphorone also effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M pha | |||
TN6059 |
Demethoxyfumitremorgin C
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Demethoxyfumitremorgin C and tryprostatin B are fungal inhibitors of mammalian cell cycle progression at the G(2)/M transition. Demethoxyfumitremorgin C inhibits the proliferation of PC3 human prostate cancer cells via the intrinsic (mitochondrial) and ex | |||
T82406 |
FF-MAS
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FF-MAS是一种有效的meiotic maturation激动剂,能促进小鼠卵母细胞在体外成熟,促进其发展到MII阶段,并增强从2细胞阶段到囊胚阶段转变的潜力。 |