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97

抑制剂 & 化合物

18

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3481	Bimolane	Topoisomerase	DNA Damage/DNA Repair
	Bimolane 是一种拓扑异构酶 II 抑制剂。
T8527	CPYPP	Others	Others
	CPYPP 是DOCK2-Rac1相互作用的抑制剂。它能够结合DOCK2DHR-2结构域，并以剂量依赖性方式抑制 DOCK2DHR-2 (IC50:22.8 µM) 对 Rac1 的鸟嘌呤核苷酸交换因子活性。它还抑制DOCK180和DOCK5，对 DOCK9 的抑制作用较小。
T23256	RS-25344 hydrochloride	PDE	Metabolism
	RS 25344 hydrochloride 是 cAMP-磷酸二酯酶 4 的选择性抑制剂，在人淋巴细胞中的 IC50为 0.28 nM，对 PDE I、II、III 仅具有微弱的抑制作用，IC50分别为 >100 μM、160 μM、330 μM。它具有抗炎、增强记忆力和认知能力以及抗肿瘤活性。
T6588	Mitoxantrone 米托蒽醌,mitozantrone	Topoisomerase; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair
	Mitoxantrone (mitozantrone) 是一种拓扑异构酶 II 的抑制剂，也可抑制蛋白激酶C (PKC)，IC50值为8.5 μM。
T10765	Eragidomide CC-90009,Cereblon modulator 1	Apoptosis; Ligand for E3 Ligase; Molecular Glues	Apoptosis; PROTAC
	Eragidomide (CC-90009; Cereblon modulator 1) 是一种 GSPT1 选择性 cereblon (CRBN)E3 连接酶调节剂，以分子胶的方式作用。Eragidomide 通过 CRL4CRBN 选择性靶向 GSPT1 进行泛素化和蛋白酶体降解。
T6403	Siponimod 辛波莫德,BAF-312	S1P Receptor; LPL Receptor	GPCR/G Protein
	Siponimod (BAF-312) 是有效，选择性的鞘氨醇-1-磷酸 (S1P)受体调节剂，对 S1P1 和 S1P5 受体具有特异性，EC50 分别为 0.39 nM 和 0.98 nM。 BAF312 对 S1P1 和 S1P5 受体的特异性比 S1P2、S1P3 和 S1P4 受体高 1000 倍以上。
T7739	L-Leucyl-L-Leucine methyl ester hydrochloride Leu-Leu-ome hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	L-Leucyl-L-Leucine methyl ester hydrochloride (Leu-Leu-ome hydrochloride) 是一种人单核细胞或多形核白细胞产生的 L-亮氨酸甲酯的二肽缩合产物，能够选择性消除具有细胞毒性潜能的淋巴细胞，也能够诱导溶酶体途径应激。
T0158	Mitoxantrone dihydrochloride 米托蒽醌二盐酸盐,盐酸米托蒽醌,Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride	Topoisomerase; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair
	Mitoxantrone dihydrochloride (NSC-301739) 是一种拓扑异构酶 II 的抑制剂；也可抑制蛋白激酶C (PKC)，IC50值为8.5 μM。
T6933	Peficitinib ASP015K,JNJ-54781532	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Peficitinib (ASP015K) 是一种可口服的 JAK 抑制剂，对 JAK1、JAK2、JAK3 和 Tyk2 的IC50值分别为 3.9、5.0、0.7 和 4.8 nM。
T25705	Imupedone LF1695,LF-1695,LF 1695	Others	Others
	Imupedone (LF 1695) 是一种合成免疫调节剂，可调节 T 淋巴细胞和巨噬细胞，诱导骨髓前体细胞的 T 细胞分化，增加淋巴细胞对有丝分裂原、抗原和同种异体细胞的增殖反应。
T10565	BMS-1001 hydrochloride	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	BMS-1001 hydrochloride 是一种人 PD-L1/PD-1免疫检查点的抑制剂，具有口服活性且细胞毒性低。
T26637	Antipain dihydrochloride Antipain 2HCl,BDBM-32804,BDBM 32804, Antipain,BDBM32804	Protease	Proteases/Proteasome
	Antipain dihydrochloride (Antipain 2HCl) 是一种从 Actinomycetes 提取到的蛋白酶抑制剂，具有镇痛活性，抑制 X 射线诱导的人淋巴细胞染色体畸变。
TP1758L	LCMV gp33-41 acetate LCMV gp33-41 acetate（151705-84-9 Free base）	Others	Others
	LCMV gp33-41 acetate 是淋巴细胞性脉络丛脑膜炎病毒的序列，受主要组织相容性复合体 I 类 H-2Db 限制，呈递给细胞毒性 T 淋巴细胞。
T21443	Prednicarbate Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D	Others	Others
	Prednicarbate (Hoe 777) 是一种外用皮质类固醇。Prednicarbate 可用于炎症性皮肤病的研究，如特应性皮炎。
T6964	Resiquimod R848,雷西莫特,S28463	HCV Protease; TLR	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Resiquimod (R848) 是一种 Toll 样受体7/8的激动剂，可诱导细胞因子上调。
T9919	Alemtuzumab	Others	Others
	Alemtuzumab 是人源化抗 CD52单克隆抗体， CD52是一种表达于大多数淋巴细胞以及少数的髓细胞类型的糖蛋白。Alemtuzumab 与能够特异性作用于 CD52 抗原，诱导淋巴细胞深度耗竭，恢复具有调节表型的 T 细胞和 B 细胞。。
T16132	MRE3008F20	cAMP; Adenosine Receptor	GPCR/G Protein; Neuroscience
	MRE3008F20 是一种具有种属选择性和高效性的腺苷 A3 受体（AA3R）拮抗剂，抑制 Cl-IB-MECA 诱导的 cAMP 的产生，可用于研究青光眼和哮喘。
T28918	Talviraline Bay 10-8979,HBY 097,Bay10-8979,Bay-108979,Bay108979,Bay 108979,Bay-10-8979	HIV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Talviraline (Bay 10-8979) 是一种 RNA 引导的 DNA 聚合酶抑制剂。Talviraline 对多种人类细胞系以及新鲜人类外周血淋巴细胞和巨噬细胞中的 HIV-1 诱导的细胞杀伤和 HIV-1 复制具有很强的抑制作用。
T36879L	H-Leu-Leu-OMe . HBr H-Leu-Leu-OMe . HBr (16689-14-8 Free base)	Others	Others
	H-Leu-Leu-OMe . HBr 是由人单核细胞或多形核白细胞产生的L-亮氨酸甲酯的二肽缩合产物。 H-Leu-Leu-OMe . HBr 诱导内溶酶体途径应激并选择性地消除具有细胞毒性潜力的淋巴细胞。
TP1527	CEF8, Influenza Virus NP (383-391) CEF8, Influenza Virus NP 383-391	Others	Others
	CEF8, Influenza Virus NP (383-391) 是一种甲型流感病毒核蛋白，含有 383-391 残基，是甲型流感病毒核蛋白中重要的 HLA-B*2705 限制性表位，与细胞毒性 T 淋巴细胞介导的免疫逃逸有关。
T6665	Sertaconazole nitrate FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑	Antibiotic; Antifungal	Microbiology/Virology
	Sertaconazole nitrate (FI-7045) 是一种局部广谱抗真菌药，可用于治疗浅表皮肤和粘膜感染。
T4387	evobrutinib MSC2364447C,M2951	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Evobrutinib(M2951) 也称为 M-2951 和 MSC-2364447C，是布鲁顿酪氨酸激酶(BTK) 的高选择性抑制剂，BTK 对包括 B 淋巴细胞和巨噬细胞在内的各种免疫细胞的发育和功能很重要。临床前研究表明它可能对某些自身免疫性疾病有治疗作用。
T24362	L 756423 L756423,MK-944a,MK944a,L-756,423,L-756423,MK 944a	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	L 756423 (L756423) 是一种新型有效且具有选择性和竞争性的HIV蛋白酶抑制剂，对 HIV-1 PR 的 Ki 值为0.049 nM。L 756423 能阻止HIV(IIIb)感染的 MT25 淋巴细胞在0.50-0.1nM处的扩散，可用于研究获得性免疫缺陷综合征(AIDS)。
T2171	SEW2871 SEW2871	S1P Receptor; LPL Receptor	GPCR/G Protein
	SEW 2871 是一种可口服的高选择性 S1P1激动剂，EC50为 13.8 nM。它减少血液中的淋巴细胞数量，可用于糖尿病、阿尔茨海默氏病、肝纤维化和炎症相关研究。它激活 ERK、Akt 和 Rac 信号通路，并诱导 S1P1 内在化和再循环。
T7055	Bz-RS-ISer(3-Ph)-Ome Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Bz-RS-ISer(3-Ph)-Ome (Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate) 是紫杉醇衍生物，在低细胞毒性下抑制 HSV 复制周期，阻断 Vero 细胞的有丝分裂，影响 M-MSV 诱导的肿瘤大小，并通过抑制 PHA 诱导的 T 淋巴细胞增殖而影响免疫应答。
TP1543L	G280-9 acetate(156761-76-1 free base)	Others	Others
	G280-9 acetate(156761-76-1 free base) 是一种常见的黑色素瘤 gp100 表位，受 MHC 相关 HLA-A2 限制。 G280-9 序列是独特的，因为它可以在非常低的浓度下被细胞毒性 T 淋巴细胞识别，但是它显示出低的总免疫原性，这可能是由于该肽对 HLA-A2 的亲和力相对较低。
T4674	SB297006 SB 297006	CCR	Immunology/Inflammation; Microbiology/Virology
	SB297006 是一种CCR3拮抗剂，IC50为39 nM。它能够显著抑制 CCL11 处理的神经祖细胞的增殖和神经球形成。
TQ0291	Firategrast SB 683699	Integrin	Cytoskeletal Signaling
	Firategrast (SB 683699) 是一种具有口服活性和特异性的α4β1/α4β7整合素拮抗剂。Firategrast 减少淋巴细胞进入中枢神经系统 (CNS) 的运输，降低多发性硬化症 (MS) 的活性。Firategrast 用于复发缓解性多发性硬化症。Firategrast 治疗与中位脑脊液与 CD4，CD8和CD19淋巴细胞计数的适度降低有关。
T2548	Diflorasone	Glucocorticoid Receptor	Endocrinology/Hormones
	Diflorasone 是一种皮质类固醇激素受体激动剂，具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞，并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。
T14909	CCX140 3-三氟甲基-4-氯-N-[2-[7H-吡咯并[2,3-D]嘧啶-4-羰基]-5-甲基-3-吡啶基]苯磺酰胺,CCX140-B	CCR	Immunology/Inflammation; Microbiology/Virology
	CCX140 (CCX140-B) 是 CCR2 的拮抗剂。
T11319	FR183998 free base	Na+/Ca2+ Exchanger	Membrane transporter/Ion channel
	FR183998 free base 是 Na+/Ca2+ 交换剂的抑制剂。
T28408	Phosphostim Sodium IPH1101,Phosphostim,IPH 1101,IPH-1101
	Phosphostim, a gamma9deta2 T lymphocytes agonist, is used potentially for the treatment of renal cell carcinoma, HCV infection.
T70889	Oxeclosporin
	Oxeclosporin is a hydroxyethyl derivative of serine(8)-cyclosporine; inhibits proliferation and functions of lymphocytes.
T39145	4,6-Dichloroguaiacol
	4,6-Dichloroguaiacol elicits biochemical and morphological alterations in human peripheral blood lymphocytes in vitro.
T30136	Armepavine hydrochloride, (+/-)- DL-Armepavine hydrochloride
	Armepavine hydrochloride, (+/-)- is a compound which has been shown to exert immunosuppressive effects on T lymphocytes and on lupus nephritic mice.
T31018	CP 115953 CP115953,Cp-115,953,CP-115953
	CP 115953 stimulated the production of cytokines by lymphocytes. CP 115953 inhibits the activity of topoisomerase II by interacting with the enzyme.
T70307	POM2-C-HMBP
	POM2-C-HMBP is a potent Activator of Vγ9Vδ2 T-Lymphocytes. It is also an HMBPP ananlog prodrug.
T69137	Oxophenarsine hydrochloride
	Oxophenarsine hydrochloride is a classical drug used to treat syphilis. Oxophenarsine HCl inhibits HIV-1-specific protein synthesis in acutely and persistently infected lymphocytes.
T39014	KSPWFTTL
	KSPWFTTL is an immunodominant epitope derived from the p15E transmembrane protein. It is Kb-restricted and can enhance the susceptibility of a tumor cell line to cytotoxic T lymphocytes targeting anti-AKR/Gross MuLV.
T28585	Ro 31-8588 Ro-31-8588
	Talviraline is a RNA-directed DNA polymerase inhibitor. HBY 097 is a highly potent inhibitor of HIV-1 replication and HIV-1 induced cell killing in a variety of human cell lines as well as in fresh human peripheral blood lymphocytes and macrophages.
T17099	Timapiprant sodium OC000459 sodium	Others	Others
	Timapiprant sodium inhibits mast cell activation of Th2 lymphocytes and eosinophils. Timapiprant sodium is a potent and selective D prostanoid receptor 2 antagonist. Timapiprant sodium potently displaces [3H] PGD2 from human recombinant DP2 (Ki=13 nM), ra
T27192	DMI-9523 DA-DKP,Ampion,DMI 9523,DM-9523
	DMI-9523 is nuclear factor NF-κB activation inhibitor. Antigen-stimulated human T lymphocytes produce significantly lower quantities of interferon-gamma and tumor necrosis factor-alpha after stimulation in vitro in the presence of DA-DKP. DA-DKP can modul
T82060	Interleukin-6 fragment (human)
	Interleukin-6 fragment (human) 是一种多效性细胞因子，由淋巴细胞及非淋巴细胞产生。该分子的编码基因位于人类第7号染色体，长度大约为5 kb。Interleukin-6 fragment (human) 在免疫响应、急性相应、炎症过程、癌症治疗及血液造血方面均有重要的潜在应用。
T76835	Tositumomab
	Tositumomab 是一种靶向CD20抗原的小鼠IgG2a lambda 单克隆抗体，CD20抗原存在于正常和恶性B 淋巴细胞表面。
T69723	Taminadenant mesylate
	Taminadenant, also known as PBF-509 and NIR-178, is a potent and orally active adenosine A2A receptor antagonist with potential antineoplastic activity. PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell sur...
TP1075	AUNP-12 TFA (1353563-85-5 free base) AUNP-12 TFA,NP-12 TFA
	AUNP-12 TFA (NP-12 TFA) is a polypeptide antagonist in the pd-1 signaling pathway, which has the same antagonistic effect on pd-l1 and pd-l2, and can protect the proliferation and effector function of lymphocytes.
TP1629	LCMV gp33-41 (TFA) (151705-84-9 free base) LCMV gp33-41 (TFA)
	LCMV gp33-41 (TFA), the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes[1].
T37288	Remisporine B
	Remisporine B is a polyketide and derivative of remisporine A that has been found inPenicilliumand has immunosuppressant activity.1,2It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 30.1 and 32.4 μg/ml, respectively).1 1.Liu, H., Chen, S., Liu, W., et al.Polyketides with immunosuppressive activities from mangrove endophytic fungus Penicillium sp. ZJ-SY2Mar. Drugs14(12)217(2016) 2.Kong, F., and Carter, G.T.Remisporine B, a novel dimeric chrom...
T35906	Padanamide A
	Padanamide A is a bacterial metabolite originally isolated from a marine Streptomyces species. It is active against five strains of P. falciparum (EC50s = 160-340 nM), is not cytotoxic to HEK293 or HepG2 human cell lines, but is cytotoxic to Jurkat T lymphocytes with an IC50 value of approximately 60 μg/ml.
T81697	NBI-6024
	NBI-6024 是一种变构肽配体(APL)，可被1型糖尿病患者中产生炎症性干扰素-γ的T辅助淋巴细胞识别的表位。

化合物

Cat.No: T3481

Target: Topoisomerase

Cat.No: T8527

Target: Others

RS-25344 hydrochloride

Cat.No: T23256

Target: PDE

Cat.No: T6588

Synonym: 米托蒽醌,mitozantrone

Target: Topoisomerase, PKC

Cat.No: T10765

Synonym: CC-90009,Cereblon modulator 1

Target: Apoptosis, Ligand for E3 Ligase, Molecular Glues

Cat.No: T6403

Synonym: 辛波莫德,BAF-312

Target: S1P Receptor, LPL Receptor

L-Leucyl-L-Leucine methyl ester hydrochloride

Cat.No: T7739

Synonym: Leu-Leu-ome hydrochloride

Target: Others, Endogenous Metabolite

Mitoxantrone dihydrochloride

Cat.No: T0158

Synonym: 米托蒽醌二盐酸盐,盐酸米托蒽醌,Mitoxantrone 2HCl,Mitoxantrone hydrochloride,NSC-301739,mitozantrone dihydrochloride

Target: Topoisomerase, PKC

Cat.No: T6933

Synonym: ASP015K,JNJ-54781532

Target: Tyrosine Kinases, JAK

Cat.No: T25705

Synonym: LF1695,LF-1695,LF 1695

Target: Others

BMS-1001 hydrochloride

Cat.No: T10565

Target: PD-1/PD-L1

Antipain dihydrochloride

Cat.No: T26637

Synonym: Antipain 2HCl,BDBM-32804,BDBM 32804, Antipain,BDBM32804

Target: Protease

LCMV gp33-41 acetate

Cat.No: TP1758L

Synonym: LCMV gp33-41 acetate（151705-84-9 Free base）

Target: Others

Cat.No: T21443

Synonym: Hoe 777,Hoe-777,Dermatop E emollient,UNII-V901LV1K7D

Target: Others

Cat.No: T6964

Synonym: R848,雷西莫特,S28463

Target: HCV Protease, TLR

Cat.No: T9919

Target: Others

Cat.No: T16132

Target: cAMP, Adenosine Receptor

Cat.No: T28918

Synonym: Bay 10-8979,HBY 097,Bay10-8979,Bay-108979,Bay108979,Bay 108979,Bay-10-8979

Target: HIV Protease, DNA/RNA Synthesis

H-Leu-Leu-OMe . HBr

Cat.No: T36879L

Synonym: H-Leu-Leu-OMe . HBr (16689-14-8 Free base)

Target: Others

CEF8, Influenza Virus NP (383-391)

Cat.No: TP1527

Synonym: CEF8, Influenza Virus NP 383-391

Target: Others

Sertaconazole nitrate

Cat.No: T6665

Synonym: FI-7045,Ginedermofix,FI7056,Ertaczo,硝酸舍他康唑

Target: Antibiotic, Antifungal

Cat.No: T4387

Synonym: MSC2364447C,M2951

Target: BTK

Cat.No: T24362

Synonym: L756423,MK-944a,MK944a,L-756,423,L-756423,MK 944a

Target: HIV Protease

Cat.No: T2171

Synonym: SEW2871

Target: S1P Receptor, LPL Receptor

Bz-RS-ISer(3-Ph)-Ome

Cat.No: T7055

Synonym: Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate

Target: Others, HIV Protease

G280-9 acetate(156761-76-1 free base)

Cat.No: TP1543L

Target: Others

Cat.No: T4674

Synonym: SB 297006

Target: CCR

Cat.No: TQ0291

Synonym: SB 683699

Target: Integrin

Cat.No: T2548

Target: Glucocorticoid Receptor

Cat.No: T14909

Synonym: 3-三氟甲基-4-氯-N-[2-[7H-吡咯并[2,3-D]嘧啶-4-羰基]-5-甲基-3-吡啶基]苯磺酰胺,CCX140-B

Target: CCR

FR183998 free base

Cat.No: T11319

Target: Na+/Ca2+ Exchanger

Phosphostim Sodium

Cat.No: T28408

Synonym: IPH1101,Phosphostim,IPH 1101,IPH-1101

Cat.No: T70889

4,6-Dichloroguaiacol

Cat.No: T39145

Armepavine hydrochloride, (+/-)-

Cat.No: T30136

Synonym: DL-Armepavine hydrochloride

Cat.No: T31018

Synonym: CP115953,Cp-115,953,CP-115953

Cat.No: T70307

Oxophenarsine hydrochloride

Cat.No: T69137

Cat.No: T39014

Cat.No: T28585

Synonym: Ro-31-8588

Timapiprant sodium

Cat.No: T17099

Synonym: OC000459 sodium

Target: Others

Cat.No: T27192

Synonym: DA-DKP,Ampion,DMI 9523,DM-9523

Interleukin-6 fragment (human)

Cat.No: T82060

Cat.No: T76835

Taminadenant mesylate

Cat.No: T69723

AUNP-12 TFA (1353563-85-5 free base)

Cat.No: TP1075

Synonym: AUNP-12 TFA,NP-12 TFA

LCMV gp33-41 (TFA) (151705-84-9 free base)

Cat.No: TP1629

Synonym: LCMV gp33-41 (TFA)

Cat.No: T37288

Cat.No: T35906

Cat.No: T81697

Cat. No.	Product Name	Target	Signaling Pathways
TN1697	Glucosyringic acid 葡萄糖基丁香酸	Immunology/Inflammation related	Immunology/Inflammation
	Glucosyringic acid 具有免疫抑制作用，在体外能抑制鼠 B 淋巴细胞的增殖。
T7924	8-Bromoguanosine	Others	Others
	8-Bromoguanosine 是鸟苷的溴化衍生物。它是通过细胞内机制激活淋巴细胞发挥免疫刺激作用。
T5S0777	Phellodendrine chloride	Others	Others
	Phellodendrine chloride 是一种Phellodendron amurense 中的生物碱。它通过巨胞饮抑制营养物质的吸收，进而抑制 KRAS 突变的胰腺癌细胞的增殖。
T6S0781	Phellodendrine 黄柏碱,Phallodendrin	Others; NF-κB; Akt	Cytoskeletal Signaling; NF-κB; Others; PI3K/Akt/mTOR signaling
	Phellodendrine (Phallodendrin) 是异喹啉生物碱，是黄柏皮层中的重要特征成分之一。它具有良好的抗氧化，抗炎作用。它通过调节AKT/NF-κB 途径抵抗 AAPH 诱导的氧化应激。
T37705	1,2,4-Trihydroxybenzene Benzene-1,2,4-triol	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	1,2,4-Trihydroxybenzene (Benzene-1,2,4-triol) 是咖啡豆烘焙的副产品，是在小鼠、阿拉伯咖啡中发现的。1,2,4-Trihydroxybenzene 是一种苯三醇，它能增加大鼠胸腺淋巴细胞内的Ca2+浓度。
T0798	Triamcinolone Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone	Glucocorticoid Receptor; COX	Endocrinology/Hormones; Immunology/Inflammation; Neuroscience
	Triamcinolone (Aristocort) 是一种皮质类固醇激素受体激动剂，也是一种合成的长效糖皮质激素，具有抗炎活性。
TN1861	Licoflavone C 4',5,7-Trihydroxy-8-prenylflavone	Antioxidant; Antifungal	Microbiology/Virology; oxidation-reduction
	Licoflavone C (4',5,7-Trihydroxy-8-prenylflavone) 是从 Glycyrrhiza inflata 的根部分离出来的异戊二烯基黄酮化合物，具有抗氧化和抗真菌活性，在培养的人类外周淋巴细胞中，它对 DAU 或 MMC 诱导的染色体损伤具有保护作用。Licoflavone C 可用于研究真菌感染。
T20879	Tacrolimus monohydrate FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506	Phosphatase; Others; Antibacterial; Antibiotic; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others
	Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物，它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。
T4S1943	Kirenol 奇壬醇,奇任醇,Kirel	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的，具有抗氧化、抗炎、抗过敏、抗关节炎活性，可用于缓解疼痛的研究。
T2563	Acetyl-L-carnitine hydrochloride Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) 是一种由内源性左旋肉碱的乙酰化形式的盐酸盐组成的营养补充剂，具有潜在的神经保护、认知增强、抗抑郁和免疫调节活性。还可缓解化疗、糖尿病或其他疾病引起的周围神经病变。此外，乙酰左旋肉碱可能通过增加T淋巴细胞成熟来调节免疫反应，并可能下调促炎细胞因子对病毒(如SARS-CoV-2)的反应。它还可能破坏ACE2信号通路并抑制活性氧(ROS)的产生。
T13969L	Xanthopterin 黄蝶呤,Ksantopterin	Others	Others
	Xanthopterin could inhibit the growth of lymphocytes produced by concanavalin.
T70221	Dibefurin
	Dibefurin is a metabolite that inhibits the activity of calcineurin, a calcium/calmodulin-dependent protein phosphatase involved in the activation of T lymphocytes.
T16160	Musk tibetene Musk tibetine	Others	Others
	Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell lines. Musk tibetene is a nitro musk compound with carcinogenic activity.
T75502	Brazilein
	Brazilein为从Caesalpinia sappan L.中提取的关键免疫抑制成分，能够诱导小鼠脾淋巴细胞(apoptosis)。
TN5138	Teuclatriol	TNF; NF-κB; TLR	Apoptosis; Immunology/Inflammation; NF-κB
	Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-ÎºB signaling at doses of 312µM and higher. It showed a significant anti-proliferative effect on human activated-peripheral blood lymphocytes (IC50, 72.8 ± 5.4 µg/ml).
T75692	Hypoglaunine D
	Hypoglaunine D 是 Triptonine B 的类似物，是一种抗HIV 的化合物，Hypoglaunine D 抑制 H9 淋巴细胞中HIV 病毒复制的EC50值为 22 μg/ml。
TN3152	6-Acetonyldihydrochelerythrine	ERK; BCL; Akt; HIV Protease; PPAR; p53	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; MAPK; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively. 6-Acetonyldihydrochelerythrine is
TN4084	Fumitremorgin B	Antifection	Microbiology/Virology
	Fumitremorgen B is a mycotoxin, it exhibits a certain degree of genotoxicity, it can cause DNA damage in human lymphocytes; it shows an inhibitory activity on the cell cycle progression of mouse tsFT210 cells in the M phase, with the MIC value of 26.1 mic

天然产物

Glucosyringic acid

Cat.No: TN1697

Synonym: 葡萄糖基丁香酸

Target: Immunology/Inflammation related

8-Bromoguanosine

Cat.No: T7924

Target: Others

Phellodendrine chloride

Cat.No: T5S0777

Target: Others

Cat.No: T6S0781

Synonym: 黄柏碱,Phallodendrin

Target: Others, NF-κB, Akt

1,2,4-Trihydroxybenzene

Cat.No: T37705

Synonym: Benzene-1,2,4-triol

Target: Calcium Channel

Cat.No: T0798

Synonym: Fluoxyprednisolone,曲安西龙,Aristocort,Rodinolone

Target: Glucocorticoid Receptor, COX

Cat.No: TN1861

Synonym: 4',5,7-Trihydroxy-8-prenylflavone

Target: Antioxidant, Antifungal

Tacrolimus monohydrate

Cat.No: T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

Cat.No: T4S1943

Synonym: 奇壬醇,奇任醇,Kirel

Target: Wnt/beta-catenin

Acetyl-L-carnitine hydrochloride

Cat.No: T2563

Synonym: Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride

Target: Others, Endogenous Metabolite

Cat.No: T13969L

Synonym: 黄蝶呤,Ksantopterin

Target: Others

Cat.No: T70221

Cat.No: T16160

Synonym: Musk tibetine

Target: Others

Cat.No: T75502

Cat.No: TN5138

Target: TNF, NF-κB, TLR

Cat.No: T75692

6-Acetonyldihydrochelerythrine

Cat.No: TN3152

Target: ERK, BCL, Akt, HIV Protease, PPAR, p53

Fumitremorgin B

Cat.No: TN4084

Target: Antifection

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