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1524

抑制剂 & 化合物

347

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1144L	Corticotropin-releasing factor (human) acetate Corticotropin-releasing factor (human) acetate (86784-80-7 Free base)	CRFR	GPCR/G Protein
	Corticotropin-releasing factor (human) acetate 刺激垂体前叶合成和分泌促肾上腺皮质激素。
TP1106L	α-Factor Mating Pheromone, yeast acetate Mating Factor α acetate,α-Factor Mating Pheromone, yeast acetate(59401-28-4 free base)	Others	Others
	α-Factor Mating Pheromone, yeast acetate (Mating Factor α acetate)(59401-28-4 free base) 是由酿酒酵母α细胞分泌的13个氨基酸的肽。
T8679	Epidermal Growth Factor	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Epidermal Growth Factor 与表皮生长因子受体 (EGFR) 结合并刺激细胞生长和增殖。它被批准用于治疗糖尿病足溃疡。
T38332	Complement factor D-IN-2	Complement System	Immunology/Inflammation
	Complement factor D-IN-2 是 omplement factor D 的有效抑制剂，在替代补体途径的早期和关键时刻靶向 factor D 并抑制补体级联反应。Complement factor D-IN-2在自身免疫疾病的方面有研究的价值。
T21723L	Epidermal Growth Factor Receptor Peptide Acetate Epidermal Growth Factor Receptor Peptide Acetate(96249-43-3 Free base)	Others	Others
	Epidermal Growth Factor Receptor Peptide Acetate (Epidermal Growth Factor Receptor Peptide Acetate (96249-43-3 Free base)) 存在于细胞表面，通过与其特异性配体的结合而被激活。EGFR 属于受体酪氨酸激酶(RTK) 的 ErbB 家族。
TP1155L	Human growth hormone-releasing factor acetate	GHSR	GPCR/G Protein
	Human growth hormone-releasing factor acetate 是一种下丘脑多肽，通过与垂体前叶细胞上的 GHRH 受体 (GHRHR) 结合来刺激 GH 的产生和释放。
T12218	NFAT Transcription Factor Regulator-1	IL Receptor	Immunology/Inflammation
	NFAT Transcription Factor Regulator-1 是 IL-2 合成的抑制剂，IC50 值为182 nM。
T28869	Streptomyces A-Factor A-Factor (Lactone)
	Streptomyces A-Factor is a microbial hormone found in Streptomyces griseus. A-factor triggers streptomycin biosynthesis and cell differentiation by binding a repressor-type receptor protein (ArpA) and dissociating it from DNA.
T30743	Carbon dioxide reduction factor Methanofuran,Cdr factor
	Carbon dioxide reduction factor is a coenzyme of methanogenesis from carbon dioxide.
T36523	Extracellular Death Factor
	Programmed cell death in bacteria is dependent on a system of cell-to-cell communication termed quorum sensing. Extracellular death factor (EDF) is a linear pentapeptide that communicating cells produce and release, which upon reaching a sufficient concentration activates the cell death pathway in a subset of cells. It is sensitive to extreme pH, high temperatures, and other stressful conditions. At 2.5 ng/ml, EDF has been shown to facilitate mazEF-mediated cell death, significantly reducing pop...
TP1144	Corticotropin-releasing factor (human) Human corticotropin-releasing factor,Human CRF,Corticotropin-releasing factor human
	Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions b
TP1106	α-Factor Mating Pheromone, yeast Mating Factor α
	Alpha factor mating pheromone is a peptide of 13 amino acids secreted by Saccharomyces cerevisiae α cells.
T38969	Factor B-IN-1
	Factor B-IN-1 is a Factor B inhibitor.
T22774L	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)	Others	Others
	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) 是延伸因子 1 亚基。真核翻译延伸因子 1 alpha 1 (EEF1A1) 编码延伸因子 alpha 亚基的同种型- 1 复合物，负责将氨酰 tRNA 酶促递送至核糖体。这种亚型（α 1）在脑、胎盘、肺、肝、肾和胰腺中表达，另一种亚型（α 2）在脑、心脏和骨骼肌中表达。这种亚型在 66% 的 Felty 综合征患者中被鉴定为自身抗原。已发现该基因在许多染色体上具有多个拷贝，其中一些（如果不是全部）代表不同的假基因。
T38803	Factor D inhibitor 6
	Factor D inhibitor 6 is a potent, highly selective, orally active compound that specifically inhibits the activity of factor D (FD). It demonstrates an IC50 of 30 nM and a Kd of 6 nM. Notably, Factor D inhibitor 6 does not exhibit any inhibitory effects against factor B, classical and lectin complement-pathway activation, nor does it interfere with a broad array of receptors, ion channels, kinases, and proteases.
T40459	Transcriptional Intermediary Factor 2 (TIF2) (740-753) Transcriptional Intermediary Factor 2 (TIF2) (740-753)
	Transcriptional Intermediary Factor 2 (TIF2) (740-753) is a 14-amino acid peptide that serves as a coactivator of TIF-2 protein. It specifically covers residues 740-753 of the TIF-2 protein.
TP1155	Human growth hormone-releasing factor Growth Hormone Releasing Factor human
	Human growth hormone-releasing factor stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.Growth hormone-releasing hormone is a hormone produced in the hypothalamus. The main role of growth hormo
T41065	Atrial natriuretic factor (1-28) (human, porcine) Atrial natriuretic factor (1-28) (human, porcine),Atrial natriuretic peptide (1-28)
	Atrial natriuretic factor (1-28) from both human and porcine sources is a powerful suppressor of pro-opiomelanocortin (POMC) mRNA, while it only has a modest inhibition effect on βEP-LI release.
T37111	Corticotropin-releasing factor (human) (acetate)
	Human CRF acetate is a chemical compound that effectively stimulates the synthesis and secretion of adrenocorticotropin in the anterior pituitary.
TP1105	α-Factor Mating Pheromone, yeast (TFA) α-Factor Mating Pheromone, yeast (TFA)(59401-28-4,FREE),Mating Factor α (TFA)
	The alpha factor pheromone arrests yeast in the G1 phase of their cell cycle. Alpha Factor Mating Pheromone induces the expression of mating genes, changes in nuclear architecture, and polarzes growth toward the mating partner.
T19750	Spinosad Factor D
	Spinosad Factor D is a naturally derived fermentation product. It is used as a pesticide against many different insects.
TP1030	Thymus factor X TFX-Jelfa,胸腺因子X
	Thymic factor X (TFX-Jelfa) is an aqueous extract from the thymus of a juvenile calf and is a natural stimulator of lymphocyte function.
T80986	Thymus Factor
	Thymus Factor 是重要的生化物质，负责促进体液免疫功能的成熟。
T16898	Complement factor D-IN-1	Others	Others
	Complement factor D-IN-1 is an effective and selective small-molecule reversible factor d inhibitor (IC50s: 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively).
T31742	Factor 390 A F390-A,F390A,P-5-(S)-N-(N-(1-Oxo-2-(phosphonooxy)propyl)-L-gamma-glutamyl)-L-glutamate,F390 A
	Factor 390 A is a phosphodiester between AMP & methanogen factor 420.
TP2247	eukaryotic translation initiation factor 3	Others	Others
	Eukaryotic initiation factors (eIF) are proteins involved in the initiation phase of eukaryotic translation. Eukaryotic translation initiation factor 3 binds to the ribosome subunit-mRNA complex. It has been implicated in preventing the large ribosomal subunit from binding the small subunit before it is ready to commence elongation.
T8680	FIBROBLAST GROWTH FACTOR, BASIC, HUMAN
	FIBROBLAST GROWTH FACTOR, BASIC, HUMAN 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T8680，CAS号为 62031-54-3。
T80059	Complement factor I	Endogenous Metabolite	Metabolism
	Complement factor I，一丝氨酸蛋白酶，可与辅助因子H (FH)、补体受体1 (CR1/CD35)、C4结合蛋白 (C4BP) 或膜辅助因子蛋白 (MCP/CD46) 结合，调控液相及/或细胞表面补体系统的活性。
TP2466	Platelet factor 4 (59-70) PF4 (59-70)
	Platelet factor 4 (59-70) elicits human neutrophil & monocyte chemotaxis.
TP1122L	IGF-I 30-41 acetate(82177-09-1 free base) Insulin-like Growth Factor I (30-41) acetate	Others	Others
	IGF-I 30-41 acetate(82177-09-1 free base) (Insulin-like Growth Factor I (30-41) acetate) 是胰岛素样生长因子 I (IGF-I) 的氨基酸 30 至 41 片段。
TP1667	Platelet Factor 4 (58-70), human
	Platelet Factor 4 (58-70), human is a polypeptide based on the 58-70 amino acid sequence of Platelet Factor 4 (pf-4) residues.
T125089	Euphorbia factor L25
	Euphorbia factor L25 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125089。
T125686	Euphorbia factor L22
	Euphorbia factor L22 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125686。
T126086	Euphorbia factor L9
	Euphorbia factor L9 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126086。
T125685	Euphorbia factor L24
	Euphorbia factor L24 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125685。
T63234	Factor XI-IN-1
	Factor XI-IN-1 是 factor XI 活化 (factor XI activation) 抑制剂(EC50: 25.14 nM)。
T62276	Factor B-IN-3
	Factor B-IN-3 是一种补体因子 B (complement factor B) 的有效抑制剂。Factor B-IN-3 能够用于研究炎症和免疫相关疾病。
T37819	Brain-Derived Acidic Fibroblast Growth Factor (102-111) (bovine) (trifluoroacetate salt)
	Brain-derived acidic fibroblast growth factor (102-111) is a peptide fragment of brain-derived acidic fibroblast growth factor (aFGF). aFGF is an angiogenic vascular endothelial cell mitogen produced in bovine brain that has sequence homology to interleukin-1. It also shares sequence homology with the known neuropeptides neuromedin C , bombesin , neuromedin K , substance K , substance P , physalaemin, and eledoisin. aFGF (102-111) corresponds to amino acid residues 102-111 of the fulllength pept...
T37820	Brain-Derived Basic Fibroblast Growth Factor (1-24) (bovine) (trifluoroacetate salt)
	Brain-derived basic fibroblast growth factor (1-24) (brain-derived bFGF) is a peptide fragment of brain-derived bFGF. bFGF is a peptide produced in bovine brain that is protective in a rat model of pressure-induced retinal ischemia. bFGF (1-24) corresponds to amino acid residues 1-24 of the full length peptide.
T62688	Factor B-IN-4
	Factor B-IN-4 是一种补体因子 B (complement factor B) 的有效抑制剂 (IC50: 1 μM)。Factor B-IN-4 能够用于研究炎症和免疫相关疾病。
T62292	Factor B-IN-2
	Factor B-IN-2 是一种补体因子 B (complement factor B) 的有效抑制剂 (IC50: 1.5 μM)。Factor B-IN-2 能够用于研究炎症和免疫相关疾病。
T37595	Brain-Derived Acidic Fibroblast Growth Factor (1-11) (bovine) (trifluoroacetate salt)
	Brain-derived acidic fibroblast growth factor (brain-derived aFGF) (1-11) is a peptide fragment of brain-derived aFGF. Brain-derived aFGF is an angiogenic vascular endothelial cell mitogen produced in bovine brain that has sequence homology to interleukin-1. aFGF (1-11) corresponds to amino acid residues 1-11 of the full length peptide.
T62689	Factor B-IN-5
	Factor B-IN-5 是一种补体因子 B (complement factor B) 的有效抑制剂 (IC50: 1.2 μM)。Factor B-IN-4 能够用于研究炎症和免疫相关疾病。
T82458	Epigenetic factor-IN-1	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Epigenetic factor-IN-1（40569Z）是一种针对SIRT7显示出强效结合能力的表观遗传因子抑制剂，常用于肝癌的研究领域。
T60991	Factor VII-IN-1
	Factor VII-IN-1 (example 43) 具有抗凝血活性，它是一种有效的因子 VII (FVII) 的抑制剂，IC50值为1.1 μM。
TP2221L	ANP (1-11), rat acetate Atrial natriuretic factor (1-11) acetate,ANP (1-11), rat醋酸盐,Atriopeptide (1-11) acetate	Others	Others
	ANP (1-11), rat acetate (Atrial natriuretic factor (1-11) acetate) 是心房利钠因子之一，是 CRF 刺激的 ACTH 分泌的抑制剂。
TP1218	Atrial natriuretic factor (1-28) (rat) TFA Atrial Natriuretic Peptide (ANP) (1-28), rat TFA
	Atrial Natriuretic Peptide (ANP) (1-28),rat (TFA) is the main circulating forms of Atrial Natriuretic Peptide (ANP) in rats, which strongly inhibit the secretion of Ang II - stimulated endothelin-1.
TP2229	Epidermal growth factor receptor (994-1002) acetyl/amide	Others	Others
	The epidermal growth factor receptor is the cell-surface receptor for members of the epidermal growth factor family of extracellular protein ligands.
T81087	Stick Insect Hypertrehalosaemic Factor II
	Stick Insect Hypertrehalosaemic Factor II为合成肽，展现出与天然样品一致的FAB光谱、反相高效液相色谱特性以及生物活性，适用于高海藻糖效应的研究。
T76539	Insulin-like growth factor II
	Insulin-like growth factor II (IGF-2)为人血清中主要生长激素，对神经突生长具有许可性和直接作用，同时增强交感与感觉神经元的生存能力。

化合物

Corticotropin-releasing factor (human) acetate

Cat.No: TP1144L

Synonym: Corticotropin-releasing factor (human) acetate (86784-80-7 Free base)

Target: CRFR

α-Factor Mating Pheromone, yeast acetate

Cat.No: TP1106L

Synonym: Mating Factor α acetate,α-Factor Mating Pheromone, yeast acetate(59401-28-4 free base)

Target: Others

Epidermal Growth Factor

Cat.No: T8679

Target: EGFR

Complement factor D-IN-2

Cat.No: T38332

Target: Complement System

Epidermal Growth Factor Receptor Peptide Acetate

Cat.No: T21723L

Synonym: Epidermal Growth Factor Receptor Peptide Acetate(96249-43-3 Free base)

Target: Others

Human growth hormone-releasing factor acetate

Cat.No: TP1155L

Target: GHSR

NFAT Transcription Factor Regulator-1

Cat.No: T12218

Target: IL Receptor

Streptomyces A-Factor

Cat.No: T28869

Synonym: A-Factor (Lactone)

Carbon dioxide reduction factor

Cat.No: T30743

Synonym: Methanofuran,Cdr factor

Extracellular Death Factor

Cat.No: T36523

Corticotropin-releasing factor (human)

Cat.No: TP1144

Synonym: Human corticotropin-releasing factor,Human CRF,Corticotropin-releasing factor human

α-Factor Mating Pheromone, yeast

Cat.No: TP1106

Synonym: Mating Factor α

Factor B-IN-1

Cat.No: T38969

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)

Cat.No: T22774L

Target: Others

Factor D inhibitor 6

Cat.No: T38803

Transcriptional Intermediary Factor 2 (TIF2) (740-753)

Cat.No: T40459

Synonym: Transcriptional Intermediary Factor 2 (TIF2) (740-753)

Human growth hormone-releasing factor

Cat.No: TP1155

Synonym: Growth Hormone Releasing Factor human

Atrial natriuretic factor (1-28) (human, porcine)

Cat.No: T41065

Synonym: Atrial natriuretic factor (1-28) (human, porcine),Atrial natriuretic peptide (1-28)

Corticotropin-releasing factor (human) (acetate)

Cat.No: T37111

α-Factor Mating Pheromone, yeast (TFA)

Cat.No: TP1105

Synonym: α-Factor Mating Pheromone, yeast (TFA)(59401-28-4,FREE),Mating Factor α (TFA)

Spinosad Factor D

Cat.No: T19750

Thymus factor X

Cat.No: TP1030

Synonym: TFX-Jelfa,胸腺因子X

Thymus Factor

Cat.No: T80986

Complement factor D-IN-1

Cat.No: T16898

Target: Others

Cat.No: T31742

Synonym: F390-A,F390A,P-5-(S)-N-(N-(1-Oxo-2-(phosphonooxy)propyl)-L-gamma-glutamyl)-L-glutamate,F390 A

eukaryotic translation initiation factor 3

Cat.No: TP2247

Target: Others

FIBROBLAST GROWTH FACTOR, BASIC, HUMAN

Cat.No: T8680

Complement factor I

Cat.No: T80059

Target: Endogenous Metabolite

Platelet factor 4 (59-70)

Cat.No: TP2466

Synonym: PF4 (59-70)

IGF-I 30-41 acetate(82177-09-1 free base)

Cat.No: TP1122L

Synonym: Insulin-like Growth Factor I (30-41) acetate

Target: Others

Platelet Factor 4 (58-70), human

Cat.No: TP1667

Euphorbia factor L25

Cat.No: T125089

Euphorbia factor L22

Cat.No: T125686

Euphorbia factor L9

Cat.No: T126086

Euphorbia factor L24

Cat.No: T125685

Factor XI-IN-1

Cat.No: T63234

Factor B-IN-3

Cat.No: T62276

Brain-Derived Acidic Fibroblast Growth Factor (102-111) (bovine) (trifluoroacetate salt)

Cat.No: T37819

Brain-Derived Basic Fibroblast Growth Factor (1-24) (bovine) (trifluoroacetate salt)

Cat.No: T37820

Factor B-IN-4

Cat.No: T62688

Factor B-IN-2

Cat.No: T62292

Brain-Derived Acidic Fibroblast Growth Factor (1-11) (bovine) (trifluoroacetate salt)

Cat.No: T37595

Factor B-IN-5

Cat.No: T62689

Epigenetic factor-IN-1

Cat.No: T82458

Target: Sirtuin

Factor VII-IN-1

Cat.No: T60991

ANP (1-11), rat acetate

Cat.No: TP2221L

Synonym: Atrial natriuretic factor (1-11) acetate,ANP (1-11), rat醋酸盐,Atriopeptide (1-11) acetate

Target: Others

Atrial natriuretic factor (1-28) (rat) TFA

Cat.No: TP1218

Synonym: Atrial Natriuretic Peptide (ANP) (1-28), rat TFA

Epidermal growth factor receptor (994-1002) acetyl/amide

Cat.No: TP2229

Target: Others

Stick Insect Hypertrehalosaemic Factor II

Cat.No: T81087

Insulin-like growth factor II

Cat.No: T76539

Cat. No.	Product Name	Target	Signaling Pathways
TN1635	Euphorbia factor L8 大戟因子L8	Others	Others
	Euphorbia factor L8 is a natural product
TN1634	Euphorbia factor L7b 千金子素L7B	Others	Others
	Euphorbia factor L7b 是从大戟属植物大戟中提取的天然产物。
T2S0410	Euphorbia factor L1 Euphorbiasteroid,大戟因子L1,大戟因子 L1	Apoptosis; P-gp	Apoptosis; Membrane transporter/Ion channel; Neuroscience
	Euphorbia factor L1 (Euphorbiasteroid) 可降低 Bcl-2，PI3K，AKT 和 mTOR 蛋白和 mRNA 水平，上调 caspase-9 and caspase-3 蛋白水平。它可诱导自噬，具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用。
T5798	Euphorbia Factor L2 千金子素L2,euphorbiafactor L2,大戟因子L2	Apoptosis; NF-κB	Apoptosis; NF-κB
	Euphorbia Factor L2 是从大戟种子中分离得到的一种赤藓烷二萜，显示强烈的细胞毒性并通过线粒体途径诱导细胞凋亡，具有抗癌活性。
T125211	Deoxy euphorbia factor L1	Others	Others
	Deoxy euphorbia factor L1是一种天然产物，存在于植物续随子 Euphorbia lathyris L 的种子中。
T78500	α-Factor Mating Pheromone, yeast TFA Mating Factor α TFA
	α-Factor Mating Pheromone, yeast (TFA)为一来自S. cerevisiae的α细胞分泌的十三肽，通过Ste2p受体发挥作用。
TN1633	Euphorbia factor L7a 大戟因子L7A	Others	Others
	Euphorbia factor L7a is a natural product
T3220	Euphorbiasteroid Euphobiasteroid,Euphorbia factor L1,千金子甾醇	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	Euphorbiasteroid (Euphobiasteroid) 是续随子中的一种三环二萜，可抑制酪氨酸酶活性，增强AMPK 的磷酸化。它通过减少细胞内甘油三酯的积累来降低 3T3-L1 细胞的分化，具有抗癌、抗病毒、抗肥胖及多重耐药调节作用。
T1255	Tobramycin NSC 180514,妥布霉素,Nebramycin Factor 6,Deoxykanamycin B	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Tobramycin (NSC-180514) 是一种胃肠外给药的广谱氨基糖苷类抗生素，可研究由于敏感生物引起的中度至重度细菌感染疾病。
TQ0099	20-O-Acetylingenol-3-angelate 巨大戟醇-3-O-当归酸-20-乙酸酯,Euphorbia factor Pe1	Others	Others
	20-O-Acetylingenol-3-angelate (Euphorbia factor Pe1) 是一种天然化合物，存在于植物英加的叶子和茎中。它具有多种生物活性，包括抑制肿瘤生长、抗炎、抗真菌和抗氧化作用。
T4S2014	5,15-Diacetyl-3-benzoyllathyrol ，大戟因子L3,二乙酰基苯甲酰基香豌豆醇,5,15-二乙酰基-3-苯甲酰千金子二萜醇；千金二萜醇二乙酰苯甲酰酯,Euphorbia factor L3	Others	Others
	5,15-Diacetyl-3-benzoyllathyrol (Euphorbia factor L3) 是一种具有抗癌作用的萜类化合物。
T5688	Micheliolide	NOS; NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Micheliolide 是一种倍半萜内酯，能够抑制各种炎症反应。它能减弱高糖刺激的NF-κB 活化，IκBα的降解，和MCP-1，TGF-β1，FN 在鼠系膜细胞的表达。
T4S0217	HOMOPLANTAGININ	TNF; NF-κB	Apoptosis; NF-κB
	Homoplantaginin 是来自中药荔枝草的一种类黄酮，具有抗炎和抗氧化活性。
TN1131	Handelin	NF-κB; Immunology/Inflammation related	Immunology/Inflammation; NF-κB
	Handelin 是一种来自 Chrysanthemum boreale 的愈创木酚内酯二聚体，它能够阻碍 NF-κB 活化和促炎细胞因子产生，具有抗炎作用。
T10383	Asatone	NF-κB	NF-κB
	Asatone 是一种从细辛中分离到的活性成分，通过活化 NF-κB 及下调 p-MAPK (ERK，JNK 和 p38) 通路起作用，具有抗炎作用。
T13686	Ergolide	NF-κB	NF-κB
	Ergolide, a sesquiterpene lactone extracted from the dried flowers of Inula Britannica, effectively hinders the expression of inducible nitric oxide synthase and cyclo-oxygenase-2 in RAW 264.7 macrophages by deactivating NF-κB.
T4S1540	Myrislignan	Apoptosis; NF-κB	Apoptosis; NF-κB
	Myrislignan 是一种木酚素，从Myristica fragransHoutt 分离得到，具有抗炎作用。它通过抑制NF-kB 信号通路的激活，减轻LPS 诱导的小鼠巨噬细胞炎症反应。
T3S0807	Berbamine	CaMK; NF-κB; Autophagy	Autophagy; Neuroscience; NF-κB
	Berbamine 是从黄柏中提取的一种天然产物，是钙通道阻滞剂，具有抗肿瘤、免疫调节和心血管作用。
TMA0507	Tomatidine	NF-κB; JNK; Autophagy	Autophagy; MAPK; NF-κB
	Tomatidine 通过阻断 NF-κB 和 JNK 信号传导而发挥抗炎作用。它在哺乳动物细胞或秀丽隐杆线虫中激活自噬。
T3S1641	Esculentoside H	TNF; NF-κB; JNK	Apoptosis; MAPK; NF-κB
	Esculentoside H 是一种皂苷，分离自多年生植物 Phytolacca esculent 的根提取物中，具有抗肿瘤作用。它的机制与 TNF 释放能力有关。它能够阻断 JNK1/2和 NF-κB 信号介导的基质金属蛋白酶-9 (MMP-9) 表达，抑制结肠癌细胞迁移。
T16324	Nimbolide	Apoptosis; NF-κB; CDK	Apoptosis; Cell Cycle/Checkpoint; NF-κB
	Nimbolide 是源自印楝叶和花的一种三萜。它抑制CDK4/CDK6激酶活性。它抑制 NF-κB，Wnt，PI3K-Akt，MAPK 和 JAK-STAT 信号通路。它通过抑制NF-κB 而诱导肿瘤细胞凋亡。
T5795	Suberosin 软木花椒素	Others; NF-κB	NF-κB; Others
	Suberosin 可分离自Plumbago zeylanica 中，通过调节NF-AT 和NF-κB，抑制PHA-诱导的 PBMC 细胞增殖并捕获细胞周期G1过渡到 S 期，具有抗炎和抗血凝的活性。
T3251	Stachydrine Hydrochloride	NF-κB	NF-κB
	Stachydrine hydrochloride 是Herba Leonuri 的主要活性成分，可以抑制NF-κB 信号通路。它可用于心血管疾病的研究，具有抗心肌肥大活性。
T3S1707	Dendrophenol Moscatilin	NF-κB	NF-κB
	Dendrophenol (Moscatilin) 是从石斛茎中分离出来的天然产物，可作为 NF-κB 抑制剂。它有抗肿瘤活性。
TL0016	Sulforaphene 油菜	Apoptosis; ERK; EGFR; NF-κB	Angiogenesis; Apoptosis; JAK/STAT signaling; MAPK; NF-κB; Tyrosine Kinase/Adaptors
	Sulforaphene 是从萝卜种子中分离出来的天然产物，对鹿茸幼苗的 ED50 约为 2 x 10 -4 M。它通过抑制 EGFR、p-ERK1/2、NF-κB 和其他信号促进癌细胞凋亡并抑制迁移。
T3877	Esculentoside A	NF-κB; COX	Immunology/Inflammation; Neuroscience; NF-κB
	Esculentoside A 是一种三萜皂苷，从商陆根部分离得到。它在具有抗炎活性，对环氧合酶-2 具有选择性抑制活性。它通过抑制NF-κB 和丝裂原活化蛋白激酶信号通路抑制 LPS 诱导的急性肺损伤中的炎症反应。
TN2008	Okanin	NF-κB; TLR	Immunology/Inflammation; NF-κB
	Okanin 是鬼针草中的一种有效成分，可通过抑制TLR4/NF-κB 信号通路减弱 LPS 诱导的小胶质细胞活化。
T4S0800	Demethyleneberberine	P450; NOS; NF-κB; HIF; AMPK	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	Demethyleneberberine 是从黄连中提取的一种天然产物，是线粒体靶向抗氧化剂。它也可作为AMPK 激活剂，用于非酒精性脂肪性肝病的研究。它通过抑制NF-κB 通路和调节 Th 细胞的平衡来减轻小鼠结肠炎并抑制炎症反应。
T6S0119	Dauricine 蝙蝠葛碱	Apoptosis; Others; NF-κB	Apoptosis; NF-κB; Others
	Dauricine 是存在于北豆根粉末中的一种双苯异喹啉生物碱，具有抗炎活性。它通过抑制NF-κB 激活，剂量依赖性地抑制结肠癌细胞的增值和侵袭，并诱导凋亡。
T11060	DMAPT Dimethylamino Parthenolide	NF-κB	NF-κB
	DMAPT (Dimethylamino Parthenolide) 是一种具有口服活性的NF-κB 抑制剂，是一种 Parthenolide (PTL) 的类似物，对原发性急性髓性白血病细胞的LD50值为1.7 μM。具有潜在的抗肿瘤和抗转移作用。
T5S2129	Sciadopitysin	TNF; NF-κB	Apoptosis; NF-κB
	Sciadopitysin 是一种双黄酮类化合物，来自银杏叶片中。它通过抑制NF-κB 活化并降低c-Fos 和NFATc1的表达来抑制 RANKL 诱导的破骨细胞生成和骨丢失。
T3893	Forsythoside B 连翘酯苷 B,连翘脂苷B	TNF; NF-κB	Apoptosis; NF-κB
	Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha，IL-6，IκB，调节 NF-κB。它抑制炎症反应，具有抗氧化和神经保护作用。
TN1079	Deoxyelephantopin	NF-κB	NF-κB
	Deoxyelephantopin 是来自Elephantopus scaber 的，具有生物活性的天然倍半萜烯内酯，能够抑制NF-κB，MAPK，PI3K/Akt 和β-catenin 信号传导。它可广泛用于癌症方面的研究。
T3913	Saikosaponin D	Estrogen Receptor/ERR; NF-κB; Antibacterial; STAT	Endocrinology/Hormones; JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells
	Saikosaponin D 是一种从柴胡中分离到的三萜皂苷类天然产物，具有抗炎，抗菌，抗肿瘤，抗过敏作用。它抑制 selectin，STAT3和 NF-kB 的活性，活化estrogen receptor-β。
T5S1607	Morusin Mulberrochromene,桑辛素	NF-κB; Antibacterial; STAT	JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells
	Morusin (Mulberrochromene) 是从M. australis 分离的去乙烯基化黄酮，可抑制NF-κB 和STAT3的活性，具有抗菌、抗肿瘤、抗氧化等各种生物活性。
T4S1881	Aconine 乌头原碱,Jesaconine	Others; NF-κB	NF-κB; Others
	Aconine (Jesaconine) 是一种退热药，有胃麻醉作用，能够抑制核因子 κB 受体活化剂配体诱导的 NF-κB 激活。
T5834	Myrcene	Others	Others
	Myrcene 是具有可挥发性的芳香族化合物，对 TNFα 诱导的 NF-κB 具有抑制作用，且具有抗侵袭的能力。
TN1712	Gossypin	NF-κB; S6 Kinase	MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Gossypin 是一种从Hibiscus vitifolius 中分离得到的黄酮，能够抑制NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中，它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。
TQ0131	Rocaglamide Rocaglamide A,楝酰胺,Roc-A	HSP; NF-κB; PERK	Apoptosis; Cytoskeletal Signaling; Metabolism; NF-κB
	Rocaglamide (Roc-A) 是从米仔兰中分离出来的一种天然产物，具有抗癌特性，可用于咳嗽，受伤，哮喘和炎症性皮肤病。它是一种有效的选择性热休克因子 1 活化抑制剂，IC50约为 50 nM。它是 T 细胞中 NF-κB 活化的有效抑制剂，还抑制翻译起始因子eIF4A 的功能。
T6718	Zingerone Gingerone,Vanillylacetone,姜酮,NSC 15335	NF-κB	NF-κB
	Zingerone (Vanillylacetone) 是一种从生姜中得到的无毒的甲氧基苯酚，具有抗炎、抗糖尿病、抗脂质过敏、抗腹泻、抗痉挛和抗肿瘤等活性。它作为抗有丝分裂剂，能够抑制神经母细胞瘤的生长。它能够缓解氧化应激和炎症，下调 NF-κB 介导的信号通路。
T6S1572	Sauchinone	ERK; p38 MAPK; NF-κB	MAPK; NF-κB
	Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS，TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。
T3012	Mangiferin Alpizarin,Chinomin,芒果,Hedysarid	Apoptosis; Others; NF-κB; Nrf2	Apoptosis; Immunology/Inflammation; NF-κB; Others
	Mangiferin (Hedysarid) 是一种Nrf2激活剂。它抑制NF-κB 亚基p65和p50的核移位，具有抗氧化、抗糖尿病、抗高尿酸血症、抗病毒、抗癌和抗炎活性。
T2140	Parthenolide (-)-Parthenolide,小白菊内酯	Apoptosis; Mitophagy; NF-κB; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; NF-κB
	Parthenolide ((-)-Parthenolide) 是一种从药草短舌匹菊中发现的倍半萜内酯。它抑制NF-κB 活化，有抗炎活性。它还可抑制HDAC1蛋白，但不影响其他I/II 类HDAC。
T5687	WITHAFERIN A 醉茄素 A,醉茄素A	Ferroptosis; NF-κB	Apoptosis; NF-κB
	Withaferin A 是从南非醉茄中分离到的一种甾体内酯，是内皮蛋白 C 受体脱落抑制剂，可以抑制NF-kB 的活性，具有抗炎，抗肿瘤等作用。它是一种新型 NFkappaB 抑制剂，有望成为治疗各种炎症性疾病和癌症的新型抗炎药。
TN1637	Eurycomalactone	Anti-infection; NF-κB	Microbiology/Virology; NF-κB
	Eurycomalactone 是一种NF-κB 抑制剂，IC50=0.5 μM，是一种天然产物。它可抑制蛋白合成，降低 cyclin D1 蛋白水平，但对 TNFα 诱导的 IκBα 降解或 IKKα/β 和 IκBα 的磷酸化水平没有作用。
T6S0840	Engeletin Dihydrokaempferol 3-rhamnoside,黄杞苷	NF-κB; Reductase	Endocrinology/Hormones; Metabolism; NF-κB
	Engeletin (Dihydrokaempferol 3-rhamnoside) 是一种黄酮苷类物质，从hymenaea martiana 中获得，抑制NF-κB 信号通路的激活，具有抗炎、缓解疼痛、消肿、利尿、抗菌等作用。
TN1341	8-Deoxygartanin 8-脱氧藤黄苷	Beta Amyloid; NF-κB; Parasite	Microbiology/Virology; Neuroscience; NF-κB
	8-Deoxygartanin 是山竹果中的异戊烯化呫吨酮。它是丁基胆碱酯酶选择性抑制剂，对阿尔茨海默病 (AD) 具有多功能活性，可能是有希望治疗 AD 的化合物。
T6S0781	Phellodendrine 黄柏碱,Phallodendrin	Others; NF-κB; Akt	Cytoskeletal Signaling; NF-κB; Others; PI3K/Akt/mTOR signaling
	Phellodendrine (Phallodendrin) 是异喹啉生物碱，是黄柏皮层中的重要特征成分之一。它具有良好的抗氧化，抗炎作用。它通过调节AKT/NF-κB 途径抵抗 AAPH 诱导的氧化应激。
T2733	Sarsasapogenin Parigenin,知母皂苷元,Sarsagenin	Apoptosis; NF-κB; Endogenous Metabolite	Apoptosis; Metabolism; NF-κB
	Sarsasapogenin (Parigenin) 是一种甾体皂苷元，从中草药知母中分离到，具有抗糖尿病、抗氧化、抗癌、抗炎等作用。
T2726	Sinomenine Cucoline,Kukoline,青藤碱	Apoptosis; Others; NF-κB; Opioid Receptor; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience; NF-κB; Others
	Sinomenine (Kukoline) 是来自汉防己的一种生物碱，是 μ 阿片受体激活剂，也是NF-κB 活化的阻断剂。
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天然产物

Euphorbia factor L8

Cat.No: TN1635

Synonym: 大戟因子L8

Target: Others

Euphorbia factor L7b

Cat.No: TN1634

Synonym: 千金子素L7B

Target: Others

Euphorbia factor L1

Cat.No: T2S0410

Synonym: Euphorbiasteroid,大戟因子L1,大戟因子 L1

Target: Apoptosis, P-gp

Euphorbia Factor L2

Cat.No: T5798

Synonym: 千金子素L2,euphorbiafactor L2,大戟因子L2

Target: Apoptosis, NF-κB

Deoxy euphorbia factor L1

Cat.No: T125211

Target: Others

α-Factor Mating Pheromone, yeast TFA

Cat.No: T78500

Synonym: Mating Factor α TFA

Euphorbia factor L7a

Cat.No: TN1633

Synonym: 大戟因子L7A

Target: Others

Euphorbiasteroid

Cat.No: T3220

Synonym: Euphobiasteroid,Euphorbia factor L1,千金子甾醇

Target: Others, AMPK

Cat.No: T1255

Synonym: NSC 180514,妥布霉素,Nebramycin Factor 6,Deoxykanamycin B

Target: ribosome, Antibacterial, Antibiotic

20-O-Acetylingenol-3-angelate

Cat.No: TQ0099

Synonym: 巨大戟醇-3-O-当归酸-20-乙酸酯,Euphorbia factor Pe1

Target: Others

5,15-Diacetyl-3-benzoyllathyrol

Cat.No: T4S2014

Synonym: ，大戟因子L3,二乙酰基苯甲酰基香豌豆醇,5,15-二乙酰基-3-苯甲酰千金子二萜醇；千金二萜醇二乙酰苯甲酰酯,Euphorbia factor L3

Target: Others

Cat.No: T5688

Target: NOS, NF-κB, COX

HOMOPLANTAGININ

Cat.No: T4S0217

Target: TNF, NF-κB

Cat.No: TN1131

Target: NF-κB, Immunology/Inflammation related

Cat.No: T10383

Target: NF-κB

Cat.No: T13686

Target: NF-κB

Cat.No: T4S1540

Target: Apoptosis, NF-κB

Cat.No: T3S0807

Target: CaMK, NF-κB, Autophagy

Cat.No: TMA0507

Target: NF-κB, JNK, Autophagy

Esculentoside H

Cat.No: T3S1641

Target: TNF, NF-κB, JNK

Cat.No: T16324

Target: Apoptosis, NF-κB, CDK

Cat.No: T5795

Synonym: 软木花椒素

Target: Others, NF-κB

Stachydrine Hydrochloride

Cat.No: T3251

Target: NF-κB

Cat.No: T3S1707

Synonym: Moscatilin

Target: NF-κB

Cat.No: TL0016

Synonym: 油菜

Target: Apoptosis, ERK, EGFR, NF-κB

Esculentoside A

Cat.No: T3877

Target: NF-κB, COX

Cat.No: TN2008

Target: NF-κB, TLR

Demethyleneberberine

Cat.No: T4S0800

Target: P450, NOS, NF-κB, HIF, AMPK

Cat.No: T6S0119

Synonym: 蝙蝠葛碱

Target: Apoptosis, Others, NF-κB

Cat.No: T11060

Synonym: Dimethylamino Parthenolide

Target: NF-κB

Cat.No: T5S2129

Target: TNF, NF-κB

Cat.No: T3893

Synonym: 连翘酯苷 B,连翘脂苷B

Target: TNF, NF-κB

Deoxyelephantopin

Cat.No: TN1079

Target: NF-κB

Cat.No: T3913

Target: Estrogen Receptor/ERR, NF-κB, Antibacterial, STAT

Cat.No: T5S1607

Synonym: Mulberrochromene,桑辛素

Target: NF-κB, Antibacterial, STAT

Cat.No: T4S1881

Synonym: 乌头原碱,Jesaconine

Target: Others, NF-κB

Cat.No: T5834

Target: Others

Cat.No: TN1712

Target: NF-κB, S6 Kinase

Cat.No: TQ0131

Synonym: Rocaglamide A,楝酰胺,Roc-A

Target: HSP, NF-κB, PERK

Cat.No: T6718

Synonym: Gingerone,Vanillylacetone,姜酮,NSC 15335

Target: NF-κB

Cat.No: T6S1572

Target: ERK, p38 MAPK, NF-κB

Cat.No: T3012

Synonym: Alpizarin,Chinomin,芒果,Hedysarid

Target: Apoptosis, Others, NF-κB, Nrf2

Cat.No: T2140

Synonym: (-)-Parthenolide,小白菊内酯

Target: Apoptosis, Mitophagy, NF-κB, HDAC, Autophagy

Cat.No: T5687

Synonym: 醉茄素 A,醉茄素A

Target: Ferroptosis, NF-κB

Eurycomalactone

Cat.No: TN1637

Target: Anti-infection, NF-κB

Cat.No: T6S0840

Synonym: Dihydrokaempferol 3-rhamnoside,黄杞苷

Target: NF-κB, Reductase

8-Deoxygartanin

Cat.No: TN1341

Synonym: 8-脱氧藤黄苷

Target: Beta Amyloid, NF-κB, Parasite

Cat.No: T6S0781

Synonym: 黄柏碱,Phallodendrin

Target: Others, NF-κB, Akt

Cat.No: T2733

Synonym: Parigenin,知母皂苷元,Sarsagenin

Target: Apoptosis, NF-κB, Endogenous Metabolite

Cat.No: T2726

Synonym: Cucoline,Kukoline,青藤碱

Target: Apoptosis, Others, NF-κB, Opioid Receptor, Autophagy

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