首页工具

登录

搜索结果

Search Results for " element "

46

抑制剂 & 化合物

15

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T23384	SR 11302	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SR 11302 是一种类视黄醇，是一种激活蛋白-1 转录因子抑制剂，能够特异性抑制 AP-1 活性，而不会激活视黄酸反应元件 (RARE) 的转录。
T10733	CDDO-EA TP319,CDDO ethyl amide,RTA 405	Nrf2	Immunology/Inflammation
	CDDO-EA (CDDO ethyl amide) 是 Nrf2/抗氧化反应元件的激活剂。
T7297	KG-501 Naphthol AS-E phosphate,色酚AS-E磷酸盐	Epigenetic Reader Domain	Chromatin/Epigenetic
	KG-501 (Naphthol AS-E phosphate) 是一种 cAMP 反应元件结合蛋白抑制剂，IC50为6.89 μM。
T23383	SR11237 SR 11237	Others; RAR/RXR	Metabolism; Others
	SR11237 是一种泛视黄醇 X 受体 (RXR) 激动剂。 SR11237 导致 RXR/RXR 同源二聚体形成并反式激活包含 RXR 反应元件的报告基因。
T7798	FGH10019 FGH-10019	NPC1L1; Fatty Acid Synthase	Membrane transporter/Ion channel; Metabolism
	FGH10019 是固醇调节元件结合蛋白 (SREBP) 抑制剂，IC50=1 μM。
T3460	HhAntag	Hedgehog/Smoothened; Smo	GPCR/G Protein; Stem Cells
	HhAntag 是高效的、特异性的、具有口服活性的 Hh 通路的SMO 拮抗剂。
T6113	ICG-001	Apoptosis; Epigenetic Reader Domain; Wnt/beta-catenin	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells
	ICG001 是β-catenin/TCF 介导的一种转录抑制剂，选择性地阻断 β-catenin/CBP 相互作用而不干扰 β-catenin/p300 相互作用。它可特异性结合 CREB 蛋白，IC50为3 μM。
T7845	BTZO-1	Apoptosis	Apoptosis
	BTZO-1 是一种具有心脏保护活性的抗氧化反应元件激活剂。它可以结合巨噬细胞迁移抑制因子，结合的Kd 值为 68.6 nM，并且其结合需要 N 末端 Pro1。
TP1876L	CREBtide acetate(149155-45-3 free base)	PKA	Tyrosine Kinase/Adaptors
	CREBtide acetate(149155-45-3 free base) 是 PKA (Km=3.9 µM) 的合成底物，它基于 d-CREB（cAMP 反应元件结合蛋白）中的磷酸化序列。
TP1149	HIV-1 Rev (34-50) HIV-1 Rev 34-50,HIV-1 rev Protein (34-50)	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	HIV-1 Rev (34-50) (HIV-1 rev Protein (34-50)) 是一种具有抗 HIV-1 活性的 17 个氨基酸多肽。 HIV-1 Rev (34-50) 源自 HIV-1 中 Rev 的 Rev 响应元件结合域。
T5437	Gefitinib-based PROTAC 3	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Gefitinib-based PROTAC 3 通过 linker 将 EGFR 结合元件与 von Hippel-Lindau 配体结合，在 HCC827（外显子 19 del）和 H3255（L858R 突变）细胞中诱导 EGFR 降解，DC50 分别为 11.7 和 22.3 nM。
T2237	ICG001	Epigenetic Reader Domain; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells
	ICG001 (PRI-724 isomer) 拮抗 Wnt/β-catenin/TCF 介导的转录，并特异性结合元件结合蛋白(CREB) 结合蛋白 (CBP)，IC50 为 3 μM，但不是相关的转录共激活因子 p300。
T8890	653-47 hydrochloride	Epigenetic Reader Domain	Chromatin/Epigenetic
	653-47 hydrochloride 是一种增强剂，能显著增强 666-15 的 cAMP 反应元件结合蛋白 (CREB) 抑制活性。它也是 CREB 抑制剂，IC50为 26.3 μM。
T27083	Crebinostat	Epigenetic Reader Domain; Histone Acetyltransferase; HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Crebinostat 是一种有效的组蛋白去乙酰化酶 (HDAC) 抑制剂，对 HDAC1、HDAC2、HDAC3 和 HDAC6 有抑制作用， IC50 分别为 0.7 nM、1.0 nM、2.0 nM 和 9.3 nM。Crebinostat 可增加在体外神经元的突触蛋白 1 斑点沿树突 (synapsin-1 punctae along dendrites) 的密度。Crebinostat 可调节染色质介导的神经可塑性，增强小鼠的记忆。Crebinostat 可诱导组蛋白 H3 和组蛋白 H4 乙酰化，并增强 cAMP 反应元件结合蛋白 (CREB) 靶基因 Egr1 的表达。
T4317	PF 429242	NPC1L1; Lipid	Membrane transporter/Ion channel; Metabolism
	PF 429242 是甾醇调节元件结合蛋白 (SREBP) 位点 1 蛋白酶的竞争性抑制剂 (IC50 = 0.175 μM)。它对位点 1 蛋白酶对一组丝氨酸蛋白酶具有选择性。 PF-429242 抑制 CHO 细胞中胆固醇的合成速率 (IC50 = 0.53 μM)。
T6832	Fatostatin hydrobromide Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin	NPC1L1; Fatty Acid Synthase	Membrane transporter/Ion channel; Metabolism
	Fatostatin hydrobromide (Fatostatin A HBr) 是一种 SREBP 活化的特异性抑制剂，可抑制 SREBP-1 和 SREBP-2 的活化。它与 SCAP (SREBP 裂解激活蛋白) 结合，抑制 SREBPs 的 ER-Golgi 易位。它具有抗肿瘤作用，能抑制 ob/ob 小鼠的高血糖。它抑制了细胞中成脂基因的转录。
T24076	FzM1 FzM 1,FzM-1	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	FzM1 是卷曲蛋白受体 FZD4 的负变构调节剂 (NAM)。 FzM1减少 WNT5A 依赖的 WNT 反应元件 (WRE) 活性 (log EC50inh=-6.2)。 FzM1 与位于 FZD4 细胞内环 3 (ICL3) 的变构结合位点结合并改变受体的构象，从而抑制 WNT/β-连环蛋白级联反应。
T6529	Halobetasol propionate 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458	Phospholipase	Metabolism
	Halobetasol propionate (BMY-30056) 是一种在皮肤外使用的合成类固醇，具有抗炎，止痒和收缩血管的活性。
T2548	Diflorasone	Glucocorticoid Receptor	Endocrinology/Hormones
	Diflorasone 是一种皮质类固醇激素受体激动剂，具有抗炎和免疫抑制作用。它可通过细胞膜扩散进入细胞，并与细胞质中的糖皮质激素受体结合。它用于研究湿疹、牛皮癣等皮肤病。
T36493	CMLD-2	Apoptosis; HuR	Apoptosis; Chromatin/Epigenetic
	CMLD-2是一种 HuR-ARE 相互作用的抑制剂（Ki：350 nM），能竞争性地结合 HuR 蛋白并破坏其与富含腺嘌呤元素（ARE）的 mRNA 目标的相互作用。CMLD-2诱导细胞凋亡并通过 MAD2下调表现出抗肿瘤作用。CMLD-2 (1-75 μM ; 24-72 h) 对甲状腺癌细胞的活力具有抑制作用.CMLD-2 (20-30 μM ; 24-48 h) 激活 Caspases 并诱导H1299和A549细胞凋亡.CMLD-2 (30 μM ; 24-48 h) 诱导H1299和A549细胞的G1细胞周期停止和线粒体扰动。 CMLD-2（30μM；24-48小时）减少H1299细胞中HuR 和HuR 调节的mRNAs 和蛋白质的表达.CMLD-2（35μM；72小时）降低SW1736、8505C、BCPAP 和K1细胞的定向迁移能力。CMLD-2诱导SW1736、8505C、BCPAP 和K1细胞中的MAD2 mRNA 水平强烈下降。
T17031	TEI-9647	Others	Others
	TEI-9647 is a 1α,25-dihydroxy vitamin D3-26,23-lactone (1α,25-lactone) analog and is an effective VDR/vitamin D-responsive element (DRE)-mediated genomic actions antagonist.
T24606	PDE7 inhibitor S14 PDE7 inhibitor-S14,S14
	PDE7 inhibitor S14 is a cell-permeable PDE7 inhibitor that acts by targeting the cyclic adenosine monophosphate (cAMP)/cAMP-response element-binding protein (CREB) pathway.
T16322	Nicodicosapent	Others	Others
	Nicodicosapent is a fatty acid niacin conjugate. It is also an inhibitor of the sterol regulatory element-binding protein (SREBP). The sterol regulatory element-binding protein (SREBP) is a key regulator of cholesterol metabolism proteins such as PCSK9, H
T26999	CGP64222 CGP-64222,CGP 64222
	CGP64222, a peptoid Tat/transactivation response element inhibitor, inhibits human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry.
T14268	Aminooxy-PEG3-methyl ester	Others	Others
	Aminooxy-PEG3-methyl ester, a PEG-based PROTAC linker, serves as a pivotal element in the synthesis of PROTACs[1].
T40456	8-Bromoadenosine 5'-triphosphate tetrasodium 8-Br-ATP tetrasodium,8-Bromoadenosine 5'-triphosphate tetrasodium
	8-Bromoadenosine 5'-triphosphate tetrasodium (8-Br-ATP tetrasodium) is a tetrasodium ATP analogue, serving as a vital element for energy storage and metabolic processes in living organisms. ATP, a central component in vivo, plays a critical role in these functions.
T68594	NFAT:AP-1 inhibitor-10
	NFAT:AP-1 inhibitor-10 is a novel inhibitor of the NFAT:AP-1:DNA interaction on the ARRE-2 element, binding to DNA in a sequence-selective manner and inhibiting the transcription of the Il2 gene and several other cyclosporin A-sensitive cytokine genes important for the effector immune response.
T71191	Covidcil-19
	Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.
TP1876	CREBtide
	CREBtide is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).
T16664	N3-PEG4-C2-NH2 PROTAC Linker 20	Others	Others
	N3-PEG4-C2-NH2 (PROTAC Linker 20) is a PEG-based linker compound utilized for the synthesis of PROTACs. Its chemical structure enables efficient conjugation and serves as a bridging element between the target protein and the E3 ligase, facilitating targeted protein degradation[1].
T37789	Riboflavin 5'-monophosphate (sodium salt hydrate)
	Riboflavin 5'-monophosphate (FMN) is a coenzyme that is tightly bound to enzymes catalyzing oxidation and reduction reactions in a variety of biosynthetic pathways. FMN also binds the FMN riboswitch (RFN element) on RNA to alter gene regulation. FMN is a substrate of FMN phosphohydrolases and is used to study their function.
T82382	Fmoc-MMAF-OMe
	Fmoc-MMAF-OMe，一种具有Fmoc保护基团的抗癌剂和微管蛋白聚合抑制剂，其活性成分MMAF作为经典抗体偶联药物（ADCs）中的细胞毒性（ADC Cytotoxin）组分。
T79182	PPARγ agonist 8	PPAR	DNA Damage/DNA Repair; Metabolism
	PPARγ agonist8，作为PPARγ的激动剂，能够诱导过氧化物酶体增殖反应元件(PPRE)-萤光素酶活性，其EC50值为0.2 μM。
T8889	653-47
	653-47 是一种增强剂，能显著增强 666-15 的 cAMP 反应元件结合蛋白(CREB)抑制活性。653-47 也是一种非常弱的CREB 抑制剂，IC50值为 26.3 μM。
T77109	Omfiloctocog alfa
	Omfiloctocog alfa (SCT-800) 是一种重组的 factor VIII(FVIII)。FVIII 是一种必需的凝血蛋白，是液相凝血系统的关键组成部分。Omfiloctocog alfa 可用于血友病 A 的研究。
T11798	L-692429 MK-0751	GHSR; GPCR19	GPCR/G Protein
	L-692429 (MK-0751) 是一种有效的非肽基生长激素促分泌素 (GHS) 激动剂，是一种苯并内酰胺的衍生物，可逆转糖皮质激素对 GH 分泌的抑制。L-692429 对 G 蛋白偶联受体 (G protein-coupled receptor)具有很高的亲和力，可用于研究肢端肥大症和肥胖。
T76597	Prolylserine
	Prolylserine 是一种二肽，是 Mel-Ab 细胞中黑色素生成的抑制剂。Prolylserine 降低小眼相关转录因子 (MITF) 和酪氨酸酶的表达，诱导ERK 的磷酸化，但不诱导 cAMP 反应元件结合蛋白 (CREB)。
T68324	KCN1
	KCN1, a novel synthetic sulfonamide, is a HIF pathway inhibitor with potential anticancer activity in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. KCN1 specifically inhibited HIF reporter gene activity in several glioma cell lines at the nanomolar level. KCN1 also downregulated transcription of endogenous HIF-1 target genes, such as VEGF, Glut-1, and carbonic anhydrase 9, in a hypoxia-responsive element (HRE)-dependent manner. KCN1 potently inhibited the grow...
T78055	MYC-RIBOTAC	c-Myc	Cell Cycle/Checkpoint
	MYC-RIBOTAC 是一种针对MYC内部核糖体进入位点（IRES）的核糖核酸酶靶向降解剂（RIBOTAC）。该化合物结合了MYC mRNA的靶向组分以及一种可招募并激活RNA酶L1的小分子。通过降低MYC的mRNA和蛋白质表达水平，MYC-RIBOTAC诱导细胞发生凋亡，应用于抗肿瘤治疗的研究。
T21795	CRT5
	CRT5 是一种吡嗪苯甲酰胺，对经 VEGF 处理的内皮细胞中的所有三种 PKD 亚型 (对 PKD1、PKD2 和 PKD3 的 IC50s 分别为 1、2 和 1.5 nM) 都是一种有效的选择性抑制剂，并且 CRT5 减少 VEGF 诱导的内皮细胞迁移、增殖和微管生成。
T36614	DL-Sulforaphane N-acetyl-L-cysteine
	Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. DL-Sulforaphane N-acetyl-L-cysteine (SFN-NAC) is a major ...
T65994	(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
	Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation...
T21812	LT175
	LT175 是一种双重PPARα/γ配体，具有强大的胰岛素增敏作用和降低的脂肪生成特性。LT175是口服有效 PPARγ 的部分激动剂 (hPPARα:EC50=0.22 μM; mPPARα:EC50=0.26 μM; hPPARγ:EC50=0.48 μM)。LT175 与 PPARγ 相互作用并影响辅助调节因子环 AMP 反应元件结合蛋白结合蛋白和核辅助抑制因子 1 (NCoR1) 的募集。LT175 在“二苯口袋”的疏水区域中与 PPARγ 相互作用。
T36593	TEI-9648
	TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2]. TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1]. TEI-9648 has cons...
T83882	XY-4
	XY-4是1-棕榈酰基溶血磷脂酸(1-palmitoyl LPA094)的衍生物，同时也是过氧化物酶体增殖物激活受体γ(PPARγ)的激动剂。当浓度为5 µM时，能在表达过氧化物酶体增殖物反应元件(PPRE)的RAW 264.7巨噬细胞中诱导报告基因的表达。XY-4不作为溶血磷脂酸受体1(LPA1)、LPA2或LPA3的激动剂。在1 µM的浓度下，它能在体外诱导血小板聚集。XY-4诱导大鼠颈动脉内膜新生。
T36130	22(S)-hydroxy Cholesterol 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol
	22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22...

化合物

Cat.No: T23384

Target: DNA/RNA Synthesis

Cat.No: T10733

Synonym: TP319,CDDO ethyl amide,RTA 405

Target: Nrf2

Cat.No: T7297

Synonym: Naphthol AS-E phosphate,色酚AS-E磷酸盐

Target: Epigenetic Reader Domain

Cat.No: T23383

Synonym: SR 11237

Target: Others, RAR/RXR

Cat.No: T7798

Synonym: FGH-10019

Target: NPC1L1, Fatty Acid Synthase

Cat.No: T3460

Target: Hedgehog/Smoothened, Smo

Cat.No: T6113

Target: Apoptosis, Epigenetic Reader Domain, Wnt/beta-catenin

Cat.No: T7845

Target: Apoptosis

CREBtide acetate(149155-45-3 free base)

Cat.No: TP1876L

Target: PKA

HIV-1 Rev (34-50)

Cat.No: TP1149

Synonym: HIV-1 Rev 34-50,HIV-1 rev Protein (34-50)

Target: HIV Protease

Gefitinib-based PROTAC 3

Cat.No: T5437

Target: EGFR

Cat.No: T2237

Target: Epigenetic Reader Domain, Wnt/beta-catenin

653-47 hydrochloride

Cat.No: T8890

Target: Epigenetic Reader Domain

Cat.No: T27083

Target: Epigenetic Reader Domain, Histone Acetyltransferase, HDAC

Cat.No: T4317

Target: NPC1L1, Lipid

Fatostatin hydrobromide

Cat.No: T6832

Synonym: Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin

Target: NPC1L1, Fatty Acid Synthase

Cat.No: T24076

Synonym: FzM 1,FzM-1

Target: Wnt/beta-catenin

Halobetasol propionate

Cat.No: T6529

Synonym: 卤贝他索丙酸酯,Halobetasol Propionate,Ulobetasol propionate,BMY-30056,卤倍他索丙酸酯,CGP-14458

Target: Phospholipase

Cat.No: T2548

Target: Glucocorticoid Receptor

Cat.No: T36493

Target: Apoptosis, HuR

Cat.No: T17031

Target: Others

PDE7 inhibitor S14

Cat.No: T24606

Synonym: PDE7 inhibitor-S14,S14

Cat.No: T16322

Target: Others

Cat.No: T26999

Synonym: CGP-64222,CGP 64222

Aminooxy-PEG3-methyl ester

Cat.No: T14268

Target: Others

8-Bromoadenosine 5'-triphosphate tetrasodium

Cat.No: T40456

Synonym: 8-Br-ATP tetrasodium,8-Bromoadenosine 5'-triphosphate tetrasodium

NFAT:AP-1 inhibitor-10

Cat.No: T68594

Cat.No: T71191

Cat.No: TP1876

Cat.No: T16664

Synonym: PROTAC Linker 20

Target: Others

Riboflavin 5'-monophosphate (sodium salt hydrate)

Cat.No: T37789

Cat.No: T82382

PPARγ agonist 8

Cat.No: T79182

Target: PPAR

Cat.No: T8889

Omfiloctocog alfa

Cat.No: T77109

Cat.No: T11798

Synonym: MK-0751

Target: GHSR, GPCR19

Cat.No: T76597

Cat.No: T68324

Cat.No: T78055

Target: c-Myc

Cat.No: T21795

DL-Sulforaphane N-acetyl-L-cysteine

Cat.No: T36614

(6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide

Cat.No: T65994

Cat.No: T21812

Cat.No: T36593

Cat.No: T83882

22(S)-hydroxy Cholesterol

Cat.No: T36130

Synonym: 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol

Cat. No.	Product Name	Target	Signaling Pathways
T1658	Selenomethionine DL-Selenomethionine,DL-硒代蛋氨酸,Seleno-DL-methionine,硒代蛋氨酸	Amino Acids and Derivatives; Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	Selenomethionine (Seleno-DL-methionine) 是一种硒代氨基酸，是蛋氨酸的硒类似物。它具有作为植物代谢物的作用。它是硒代蛋氨酸和硒代氨基酸的成员。
T7033	Rosmanol	Antioxidant; COX	Immunology/Inflammation; Neuroscience; oxidation-reduction
	Rosmanol 能够显著抑制脂多糖诱导的 INOS、COX-2 的表达，抑制低密度脂蛋白的氧化，并具有抗炎作用。
T4717	25-Hydroxycholesterol 25-羟基胆固醇,25-羟基胆甾醇	Others; Endogenous Metabolite; HMG-CoA Reductase	Metabolism; Others
	25-Hydroxycholesterol 是胆固醇的代谢产物，由巨噬细胞响应 Toll 样受体激活而分泌。它有效抑制 B 细胞产生 IgA，EC50约为 65 nM。
T35709	N-acetyl-D-Lactosamine N-Acetyllactosamine	Endogenous Metabolite	Metabolism
	N-acetyl-D-Lactosamine (N-Acetyllactosamine) 是一种由半乳糖和N-乙酰葡萄糖组成的二糖，是各种寡糖的重要组成部分，可作为合成各种寡糖的起始材料。N-acetyl-D-Lactosamine 可能被都当作一种结构元素自然出现在各种糖结合物中，也可用于表征凝集素，具有益生元的作用。
T2915	Bardoxolone RTA 401,齐墩果烷三萜化合物,CDDO	Others; Nrf2	Immunology/Inflammation; Others
	Bardoxolone (CDDO) 是新型核调节因子激活剂。
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
T37298	Spinacine	Endogenous Metabolite	Metabolism
	Spinacine 是人内源性代谢产物。
TQ0163	Sagittatoside A Icariin-A,箭藿苷 A	Estrogen/progestogen Receptor	Endocrinology/Hormones
	Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
T13762	Luteolin 7-sulfate	Others	Others
	Luteolin 7-sulfate, derived from the marine plant Phyllospadix iwatensis Makino, suppresses TYR gene expression by intervening in a signaling pathway involving the cAMP-responsive element binding protein (CREB) and microphthalmia-associated transcription factor (MITF). This inhibition ultimately leads to a decrease in melanin synthesis.
T4S1421	Praeruptorin B Praeruptorin D,(+)-川白芷内酯	NPC1L1; Fatty Acid Synthase	Membrane transporter/Ion channel; Metabolism
	Praeruptorin B 是一种固醇调控元件结合蛋白(SREBPs)的抑制剂。
TN4383	Kazinol U	IL Receptor; IκB/IKK; NOS; NF-κB	Immunology/Inflammation; NF-κB
	Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-ÎºB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms.
T77289	5-O-Methylembelin
	5-O-Methylembelin 是一种天然异香豆素，可抑制PCSK9、低密度脂蛋白受体 (IDOL) 和甾醇调节元件结合蛋白 2 (SREBP2) mRNA 的表达。
TN4273	Isocoronarin D	Others	Others
	Isocoronarin D is a main active ingredient for inducing death of the tested cancer cells, it possesses a wide anti-cancer capability. Isocoronarin D may have potential chemopreventive activity, it can activate antioxidant response element (ARE) (EC50 57.6 ± 2.4 uM). It also shows the highest Hb F induction effect of 1.6-fold at 20 microM.
TN3539	Broussonin A	ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt	Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c
TN6501	Isololiolide
	Isololiolide has phytotoxicity, it inhibited seedling growth of cress and barnyard grass. It also showed in vitro activity against both trypomastigote and intracellular amastigotes of Trypanosoma cruzi, with IC50 values of 32 μM and 40 μM, respectively. I

天然产物

Selenomethionine

Cat.No: T1658

Synonym: DL-Selenomethionine,DL-硒代蛋氨酸,Seleno-DL-methionine,硒代蛋氨酸

Target: Amino Acids and Derivatives, Endogenous Metabolite, Autophagy

Cat.No: T7033

Target: Antioxidant, COX

25-Hydroxycholesterol

Cat.No: T4717

Synonym: 25-羟基胆固醇,25-羟基胆甾醇

Target: Others, Endogenous Metabolite, HMG-CoA Reductase

N-acetyl-D-Lactosamine

Cat.No: T35709

Synonym: N-Acetyllactosamine

Target: Endogenous Metabolite

Cat.No: T2915

Synonym: RTA 401,齐墩果烷三萜化合物,CDDO

Target: Others, Nrf2

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

Cat.No: T37298

Target: Endogenous Metabolite

Sagittatoside A

Cat.No: TQ0163

Synonym: Icariin-A,箭藿苷 A

Target: Estrogen/progestogen Receptor

Luteolin 7-sulfate

Cat.No: T13762

Target: Others

Cat.No: T4S1421

Synonym: Praeruptorin D,(+)-川白芷内酯

Target: NPC1L1, Fatty Acid Synthase

Cat.No: TN4383

Target: IL Receptor, IκB/IKK, NOS, NF-κB

5-O-Methylembelin

Cat.No: T77289

Cat.No: TN4273

Target: Others

Cat.No: TN3539

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt

Cat.No: TN6501

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼