Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nicodicosapent is a fatty acid niacin conjugate. It is also an inhibitor of the sterol regulatory element-binding protein (SREBP). The sterol regulatory element-binding protein (SREBP) is a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 824 | 5日内发货 | ||
5 mg | ¥ 1,490 | 5日内发货 | ||
25 mg | ¥ 5,780 | 6-8周 | ||
50 mg | ¥ 7,510 | 6-8周 | ||
100 mg | ¥ 12,500 | 6-8周 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,700 | 5日内发货 |
产品描述 | Nicodicosapent is a fatty acid niacin conjugate. It is also an inhibitor of the sterol regulatory element-binding protein (SREBP). The sterol regulatory element-binding protein (SREBP) is a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1. |
体外活性 | Nicodicosapent obviously suppresses ApoB secretion in a dose-dependent manner (IC50: 27 μM). Nicodicosapent displays a synergistic inhibition on secreted PCSK9 ( IC50: 17 μM). Nicodicosapent reduces the production of mature SREBP-2 protein in HepG2 cells but does not interact with the GPR109A receptor. Nicodicosapent causes time-dependent hydrolysis in HepG2 cells. |
体内活性 | Nicodicosapent (100 mg/kg p.o.) produces high plasma levels of nicotinic acid in the plasma. ApoE*3-Leiden mice treated with Nicodicosapent display an obvious reduction in PCSK9 levels, LDL particles including VLDL and LDL cholesterol, and plasma triglycerides. |
分子量 | 449.63 |
分子式 | C28H39N3O2 |
CAS No. | 1269181-69-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (222.41 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.2241 mL | 11.1203 mL | 22.2405 mL | 55.6013 mL |
5 mM | 0.4448 mL | 2.2241 mL | 4.4481 mL | 11.1203 mL | |
10 mM | 0.2224 mL | 1.112 mL | 2.2241 mL | 5.5601 mL | |
20 mM | 0.1112 mL | 0.556 mL | 1.112 mL | 2.7801 mL | |
50 mM | 0.0445 mL | 0.2224 mL | 0.4448 mL | 1.112 mL | |
100 mM | 0.0222 mL | 0.1112 mL | 0.2224 mL | 0.556 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Nicodicosapent 1269181-69-2 Others Inhibitor inhibitor inhibit