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87

抑制剂 & 化合物

19

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T72521	Efflux inhibitor-1
	Efflux inhibitor-1为一种吡唑啉[1,5-a]嘧啶类外排抑制剂，具有对ABCG2/BCRP和ABCB1的选择性靶向性，优先靶向ABCG2，其IC50值分别为0.45 μM与2.17 μM。
T8596	Ceefourin 1	MRP	Immunology/Inflammation
	Ceefourin 1 是一种具有高度选择性的多药抗性蛋白 4 (MRP4) 抑制剂。它能够抑制多种 MRP4 底物的转运，但对其他 ABC 转运蛋白无影响。它是苯并噻唑，常作为高危神经母细胞瘤的化学增敏剂。
T1050	Prazosin hydrochloride Prazosin hydrochloride,哌唑嗪盐酸盐,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,盐酸哌唑嗪,Minipress	Potassium Channel; MRP; Adrenergic Receptor; ABC; Autophagy	Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Prazosin hydrochloride (Vasoflex) 是一种选择性肾上腺素能 α-1 拮抗剂，可降低外周阻力并放松血管平滑肌。它可用于研究高血压和酒精使用障碍。它是一种合成哌嗪衍生物，具有降压抗肾上腺素能特性。它抑制有机阳离子转运蛋白 OCT-1 和 OCT-3，IC50分别为 1.8 和 13 μM 。
T16339	Norverapamil hydrochloride (±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米	Calcium Channel; P-gp; Drug Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Norverapamil hydrochloride (D591 hydrochloride) 是 Verapamil 的 N-去甲基代谢物，是 L 型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。
T12374	PAβN dihydrochloride MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride	Others; Antibacterial	Microbiology/Virology; Others
	PAβN dihydrochloride (MC-207,110 dihydrochloride) 是一种外排泵抑制剂。
T16744	Rhodamine 6G Basic Red 1,罗丹明6G,罗丹明 6G	Others	Others
	Rhodamine 6G (Basic Red 1) 是一种罗丹明类似物，可用于表征 MRP1 介导的流出的动力学，测定 Pgp 的流出，可用作激光染料和潜在的线粒体探针。
T24542	NP-313 NP 313,NSC 4264,NSC-4264,NSC4264
	NP-313 (NSC-4264) 是一种有效的抗血栓剂，对血栓素 A 2 合成和选择性抑制由 SOCC 介导的 Ca 2+ 内流有抑制作用，可以抑制血小板的聚集和活化。
T14076	A 839977 A839977,A-839977	P2X Receptor; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Neuroscience
	A 839977是一种选择性 P2X7 受体拮抗剂,具有抗炎和镇痛活性，可抑制 P2X7 受体的 BzATP 诱发的钙内流，可用于研究肾纤维化 .
T9587	CCTA-1523	Others; ABC	Membrane transporter/Ion channel; Others
	CCTA-1523 是 ABCG2 抑制剂的外排功能。它选择性地逆转癌细胞中 ABCG2 介导的 MDR。
T3525	PD150606	Cysteine Protease	Proteases/Proteasome
	PD150606 是一种具有选择性的非肽 calpain 抑制剂，具有神经保护活性，抑制 μ-calpains 和 m-calpains ，抑制红藻氨酸诱导的 Ca2+ 内流，干扰兴奋性毒性依赖性运动神经元死亡。
T24170	Iodoantipyrine 碘安替比林,Jodantipyrine,EINECS 204-966-6,Arthripur,Iodophenazone	Others	Others
	Iodoantipyrine (Arthripur) 是一种常用的指示剂，用于在正常和高CBF 条件下通过测量全身注射指示剂后的循环静脉流出量来评价大鼠。
T19649	PF-06273340 PF 6273340,PF 06273340,PF6273340,PF-6273340	Trk receptor	Tyrosine Kinase/Adaptors
	PF-06273340 是一种口服具有活力的、具有选择性的外周限制性Trk 泛抑制剂。
T16349	NSC-60339	Others; Antibacterial	Microbiology/Virology; Others
	NSC-60339 是一种外排泵抑制剂和 AcrAB-TolC 的底物，是聚对苯二甲酸衍生物，对癌症化疗有潜在作用。
T4497	Amifampridine 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine	Others	Others
	Amifampridine (3,4-Diaminopyridine) 可用于罕见肌肉疾病的研究。
T29645	Adatanserin hydrochloride WY50324 hydrochloride	5-HT Receptor	GPCR/G Protein; Neuroscience
	Adatanserin hydrochloride (WY50324 hydrochloride) 是一种新型 5-HT（1A）/5-HT（2）受体配体，具有潜在的神经保护作用，抑制内源性氨基酸缺血性外排，可用于研究抑郁症和焦虑症。
T12343	Benzquinamide BZQ,P2647,Benzoquinamide	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Benzquinamide (P2647) 是一种具有抗癌活性的止吐剂, 抑制p糖蛋白介导的药物外排，增强多重耐药细胞中抗癌药物的细胞毒性。Benzquinamide 对 α2A, α2B, 以及α2C 肾上腺素能受体（α2-AR）的 Ki值分别为 1,365, 691 和 545 nM。
T1146	Nifedipine BAY-a-1040,Procardia XL,Procardia,硝苯地平,Adalat	CaMK; Potassium Channel; Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Nifedipine (Procardia) 是一种二氢吡啶类钙通道阻滞剂，可抑制细胞外钙离子跨膜流入心肌和血管平滑肌细胞，导致主要冠状动脉和全身动脉扩张，降低心肌收缩力。它常用于心肌功能不全的相关研究。
T60165	VB124	Monocarboxylate transporter	Membrane transporter/Ion channel
	VB124 是一种具有口服活性的、有效且选择性的MCT4抑制剂。VB124 可特异性抑制 MDA-MB-231 细胞中乳酸的涌入和流出，IC50分别为 8.6 nM 和 19 nM。VB124 对 MCT4 的选择性高于 MCT1。VB124可用于心脏肥大、心力衰竭和代谢的研究。
T0939	Phenytoin 苯妥英,Diphenylhydantoin,5,5-Diphenylhydantoin	Virus Protease; Sodium Channel	Membrane transporter/Ion channel; Microbiology/Virology
	Phenytoin (5,5-Diphenylhydantoin) 是一种有效的电压门控钠离子通道阻滞剂，可减少小鼠乳腺肿瘤的生长和转移，具有抗癫痫活性。
T1433	Ritodrine hydrochloride DU21220,盐酸利托君,Ritodrine HCl,NSC 291565	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ritodrine hydrochloride (NSC 291565) 是一种 β-2肾上腺素受体激动剂。
T3148	MK-571 sodium L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor; LTR	GPCR/G Protein; Immunology/Inflammation
	MK-571 sodium (L-660711 sodium salt) 是一种可口服的选择性白三烯 D4受体拮抗剂，在豚鼠和人肺膜的 Ki 分别为0.22 和 2.1 nM。
T27609	INF55
	INF55 inhibits NorA efflux pump.
T74827	AcrB-IN-2
	Efflux pump-IN-2 是一种 AcrB 外排泵抑制剂，能够增强抗生素的作用。Efflux pump-IN-2 抑制尼罗红 (AcrB 的一种已知底物) 外排。Efflux pump-IN-2 不破坏细菌外膜，也不会在线虫模型中显示毒性。
T24434	MCC1189 MCC 1189,MCC-1189
	MCC1189 is a first-in-class MFS efflux pump CaMdr1p inhibitor.
T10944	D13-9001	Others	Others
	The KD values of D13-9001 in Escherichia coli and Pseudomonas aeruginosa were 1.15μM and 3.57μM, respectively. D13-9001 has antibiotic activity. It is an effective AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor.
T28808	SLUPP-417 SLUPP417
	SLUPP-417 is an efflux pump inhibitor (EPI) by interacting with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in Escherichia coli.
T10490	(S)-ML753286	Others	Others
	(S)-ML753286 is a breast cancer resistance protein (BCRP) inhibitor (IC50: 0.6 μM on BCRP efflux transporter).
T74828	AcrB-IN-3
	Efflux pump-IN-3为一种AcrB外排泵抑制剂，具有增强抗生素效力的特性。该化合物能阻断尼罗红（AcrB已知的一种底物）的外排，而不会破坏细菌的外膜，并且在线虫模型中未展现出毒性。
T74829	AcrB-IN-4
	Efflux pump-IN-4是一种针对AcrB外排泵的抑制剂，能够增强抗生素效果。该化合物通过抑制尼罗红（AcrB的已知底物）的外排来发挥作用，同时不破坏细菌外膜，且在线虫模型中未显示出毒性。
T28807	SLUPP-225 SLUPP 225
	SLUPP-225 is an efflux pump inhibitor (EPI) by interacting with the membrane fusion protein AcrA, a critical component of the AcrAB-TolC efflux pump in Escherichia coli.
T26911	Bromotetrandrine 5-Bromotetrandrine,W-198,BrTet,W 198,W198
	Bromotetrandrine is an P-glycoprotein inhibitor, which were developed and coadministered with chemotherapeutic drugs to overcome the effect of efflux pumps thus enhancing the chemosensitivity of therapeutics.
T29428	4010B-30 4010B30
	4010B-30 is an up-regulation of apolipoprotein A-I gene expression. It functions by promoting cholesterol efflux, ABCA1 expression, and PPAR activation.
T71735	AAL1
	AAL1 is an inhibitor of dark-grown Arabidopsis thaliana seedlings, functioning through auxin receptor Transport Inhibitor Response1 (TIR1) and depending on auxin influx and efflux carriers.
T14915	CDK12-IN-E9	CDK	Cell Cycle/Checkpoint
	CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak binding ability to CDK7/CyclinH complex (IC50> 1 μM).
T81654	NorA-IN-1
	NorA-IN-1 (Compound 16) 为NorA抑制剂，能够抑制外翻膜囊泡中NorA外排泵的活性，适用于多药耐药性研究。
T24005	DJ101 DJ-101,DJ 101
	DJ101is an effective and metabolically stable inhibitor of tubulin. It can circumvent the drug efflux pumps responsible for multidrug resistance of existing tubulin inhibitors.
T82723	ChTX-Lq2
	ChTX-Lq2为Ca2+激活的K+流出抑制剂，Kd值为43 nM。
T40898	DMHCA
	DMHCA, a potent, selective LXR agonist, specifically activates the LXR pathway's cholesterol efflux arm, avoiding triglyceride synthesis stimulation. This compound exhibits anti-inflammatory properties and is utilized in researching cholesterol homeostasis and diabetes.
T69976	WS-691
	WS-691 is a highly Potent and Orally Active ABCB1 Modulator. WS-691 significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC50 = 22.02 nM). WS-691 significantly increased the intracellular concentration of PTX and [3H]-PTX while decreasing the efflux of [3H]- PTX in SW620/Ad300 cells by inhibiting the efflux function of ABCB1. WS-691 could stabilize ABCB1 by directly binding to ABCB1 WS-691 increased the sensitivity of SW620/Ad300 cells to PTX in vi...
T69317	Dexverapamil
	Dexverapamil is the R-enantiomer of the calcium channel blocker verapamil. Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms.
T35927	C2 L-threo Ceramide (d18:1/2:0) C2 L-threo Ceramide (d18:1/2:0)
	C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide . C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1...
T12106	MRL-494	Others	Others
	MRL-494 is an antibacterial agent and is a small-molecule inhibitor of β-barrel assembly machine A (BamA) impervious to efflux and the outer membrane permeability barrier.
T25356	E17110 E-17110,E 17110
	E17110 is an LXRβ agonist. E17110 exhibited a significant activation effect on LXRβ (EC50: 0.72 μmol/L). E17110 also increased the expression of ABCA1 and ABCG1 in RAW264.7 macrophages. E17110 significantly decreased cellular lipid accumulation and promoted cholesterol efflux in RAW264.7 macrophages.
T80047	Polistes mastoparan
	Polistes mastoparan 作为一种抗菌肽，能够增强S. aureus (金黄色葡萄球菌) 的K+流失并削弱其活性，其EC50为5 μM。
T32242	IWP-051 IWP051
	IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of pote
T63267	P-gp/BCRP-IN-1
	P-gp/BCRP-IN-1 (compound 19) 是一种潜在的、相对安全的、口服有效的外排转运蛋白(P-gp 和 BCRP) 抑制剂。P-gp/BCRP-IN-1 通过抑制 P-gp 和BCRP 的外排功能产生耐药性逆转，P-gp/BCRP-IN-1可克服紫杉醇的耐药性，提高紫杉醇的口服生物利用度。
T28648	S39625 S-39625,S 39625
	S39625, an E-ring camptothecin keto analogue, is a stable, potent, and selective topoisomerase I inhibitor without being substrates of drug efflux transporters. Nanomolar concentrations of S39625 induces intense and persistent histone gamma-H2AX. The chem
T37296	GI-530159
	TREK1 and TREK2 channel activator (EC50 = 0.76 μM in Rb efflux assay in TREK1-expressing CHO cells). Exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Hyperpolarizes membrane potential of dorsal root ganglion neurons and depresses neuronal activity in vitro. Loucif et al (2018) GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability. Br.J.Pharmacol. 175 2272 PMID...
T37824	MCT4-IN-1 MCT4-IN-1
	MCT4-IN-1 is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MCT4-IN-1 targets to the cytosolic domain of MCT4. MCT4-IN-1 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MCT4-IN-1 has the potential for MCT4 transporter inhibition research[1].
T69956	KR30031
	KR30031 is a novel P-glycoprotein inhibitor with potential anticancer activity. KR30031 is a verapamil analog with fewer cardiovascular effects. The ability of KR-30031 to reduce this efflux transport is equal to that of verapamil, a well-known P-glycoprotein inhibitor. The bioavailability of paclitaxel could be enhanced by coadministration of a P-glycoprotein inhibitor, KR-30031.

化合物

Efflux inhibitor-1

Cat.No: T72521

Cat.No: T8596

Target: MRP

Prazosin hydrochloride

Cat.No: T1050

Synonym: Prazosin hydrochloride,哌唑嗪盐酸盐,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,盐酸哌唑嗪,Minipress

Target: Potassium Channel, MRP, Adrenergic Receptor, ABC, Autophagy

Norverapamil hydrochloride

Cat.No: T16339

Synonym: (±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米

Target: Calcium Channel, P-gp, Drug Metabolite

PAβN dihydrochloride

Cat.No: T12374

Synonym: MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride

Target: Others, Antibacterial

Cat.No: T16744

Synonym: Basic Red 1,罗丹明6G,罗丹明 6G

Target: Others

Cat.No: T24542

Synonym: NP 313,NSC 4264,NSC-4264,NSC4264

Cat.No: T14076

Synonym: A839977,A-839977

Target: P2X Receptor, Calcium Channel

Cat.No: T9587

Target: Others, ABC

Cat.No: T3525

Target: Cysteine Protease

Cat.No: T24170

Synonym: 碘安替比林,Jodantipyrine,EINECS 204-966-6,Arthripur,Iodophenazone

Target: Others

Cat.No: T19649

Synonym: PF 6273340,PF 06273340,PF6273340,PF-6273340

Target: Trk receptor

Cat.No: T16349

Target: Others, Antibacterial

Cat.No: T4497

Synonym: 3,4-Pyridinediamine,Pyridine-3,4-Diamine,阿米吡啶,3,4-Diaminopyridine

Target: Others

Adatanserin hydrochloride

Cat.No: T29645

Synonym: WY50324 hydrochloride

Target: 5-HT Receptor

Cat.No: T12343

Synonym: BZQ,P2647,Benzoquinamide

Target: Adrenergic Receptor

Cat.No: T1146

Synonym: BAY-a-1040,Procardia XL,Procardia,硝苯地平,Adalat

Target: CaMK, Potassium Channel, Calcium Channel, Autophagy

Cat.No: T60165

Target: Monocarboxylate transporter

Cat.No: T0939

Synonym: 苯妥英,Diphenylhydantoin,5,5-Diphenylhydantoin

Target: Virus Protease, Sodium Channel

Ritodrine hydrochloride

Cat.No: T1433

Synonym: DU21220,盐酸利托君,Ritodrine HCl,NSC 291565

Target: Adrenergic Receptor

Cat.No: T3148

Synonym: L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid

Target: Leukotriene Receptor, LTR

Cat.No: T27609

Cat.No: T74827

Cat.No: T24434

Synonym: MCC 1189,MCC-1189

Cat.No: T10944

Target: Others

Cat.No: T28808

Synonym: SLUPP417

Cat.No: T10490

Target: Others

Cat.No: T74828

Cat.No: T74829

Cat.No: T28807

Synonym: SLUPP 225

Bromotetrandrine

Cat.No: T26911

Synonym: 5-Bromotetrandrine,W-198,BrTet,W 198,W198

Cat.No: T29428

Synonym: 4010B30

Cat.No: T71735

Cat.No: T14915

Target: CDK

Cat.No: T81654

Cat.No: T24005

Synonym: DJ-101,DJ 101

Cat.No: T82723

Cat.No: T40898

Cat.No: T69976

Cat.No: T69317

C2 L-threo Ceramide (d18:1/2:0)

Cat.No: T35927

Synonym: C2 L-threo Ceramide (d18:1/2:0)

Cat.No: T12106

Target: Others

Cat.No: T25356

Synonym: E-17110,E 17110

Polistes mastoparan

Cat.No: T80047

Cat.No: T32242

Synonym: IWP051

Cat.No: T63267

Cat.No: T28648

Synonym: S-39625,S 39625

Cat.No: T37296

Cat.No: T37824

Synonym: MCT4-IN-1

Cat.No: T69956

Cat. No.	Product Name	Target	Signaling Pathways
T5S0246	Pseudoprotodioscin 山药	Others; Fatty Acid Synthase	Metabolism; Others
	Pseudoprotodioscin 是一种呋喃葡糖苷，抑制SREBP1/2和microRNA 33a/b 水平，降低胆固醇和甘油三酯合成相关的基因表达。
T19768	γ-Tocotrienol gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol,γ-生育三烯酚	Others	Others
	γ-Tocotrienol (Plastochromanol) 是一种维生素 E 的活性形式。
TN3150	6,8-Diprenylnaringenin 6,8-二异戊二烯基柚皮素,Senegalensin,Lonchocarpol A	BCRP; ABC	Membrane transporter/Ion channel
	6,8-Diprenylnaringenin (Senegalensin) 是来自蛇麻草 Humulus lupulus 的天然产物。 6,8-Diprenylnaringenin 是一种乳腺癌耐药蛋白 (BCRP) 抑制剂，具有一定雌激素作用。
T4818	Thyminose 2-脱氧-D-核糖,2-Deoxy-D-ribose,2-Deoxy-D-arabinose,2-Deoxy-D-erythropentose	Others; Endogenous Metabolite	Metabolism; Others
	Thyminose (2-Deoxy-D-arabinose) 通过抑制谷胱甘肽的合成和增加其外排诱导细胞凋亡。
T8165	Erythrodiol	Endogenous Metabolite; ABC	Membrane transporter/Ion channel; Metabolism
	Erythrodiol 是一种橄榄油的成分，能够选择性抑制ABCA1蛋白的降解来促进胆固醇外流，有用于动脉粥样硬化的研究潜力。
TN1493	Chrysosplenol D 猫眼草酚D	IL Receptor; NF-κB; JNK	Immunology/Inflammation; MAPK; NF-κB
	Chrysosplenol D 属于甲氧基黄酮类化合物，可诱导 ERK1/2 介导的三阴性人乳腺癌细胞凋亡。它还显示出抗炎和中等抗锥虫活性。
T6S0095	Genkwanin 7-O-Methylapigenin,Puddumetin,Apigenin 7-methyl ether,芫花素	Virus Protease	Microbiology/Virology
	Genkwanin (Apigenin 7-methyl ether) 是一种O-甲基化黄酮，有抗炎活性，通过被动扩散和多药耐药蛋白介导的外排机制转运。
T19554	L-Aspartic aicd sodium L-Aspartic acid sodium,Sodium L-aspartate	Others; Sodium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Others
	L-Aspartic aicd sodium (Sodium L-aspartate) 是一种氨基酸，是一种结肠特异性活性分子输送的前体活性分子，可促进大鼠前脑膜囊泡的 Na+外排。
TMA2270	Alisol F 24-acetate	P-gp	Membrane transporter/Ion channel; Neuroscience
	Alisol F 24-acetate 是一种从 Alisma plantago-aquatica Linn [1] 中分离出来的天然产物。 Alisol F 24 Acetate 通过抑制 P-糖蛋白介导的药物流出来增强 MCF-7/DOX 细胞的化学敏感性和凋亡。
TN2160	Roemerine (-)-Roemerine	Antibiotic	Microbiology/Virology
	Roemerine ((-)-Roemerine) 是一种来自塞内加尔番荔枝的卟啉生物碱，具有抗真菌和抗癌活性，通过抑制 Bmr 来防止小檗碱外排。Roemerine 以浓度依赖性方式增加细胞膜通透性，可用于研究真菌感染和前列腺癌。
T14140	Agaric acid 落叶松蕈酸,Agaricinic Acid	Mitochondrial Metabolism; AChR	Metabolism; Neuroscience
	Agaric acid (Agaricinic Acid) 来一种自真菌部落的Polyporus officinalis 和Polyporus igniarius。它可促进积累的 Ca2+流出，跨膜电位的破坏和线粒体肿胀。它通过其与腺嘌呤核苷酸转位酶的相互作用诱导线粒体通透性转变。它用于调节脂类代谢。
T6S0653	Linarin Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷	TNF; AChE	Apoptosis; Neuroscience
	Linarin (Acacetin-7-O-rutinoside) 是一种选择性的乙酰胆碱酯酶 (AChE) 抑制剂，从薄荷花提取物中分离得到。
TN5466	Boeravinone B
	Boeravinone B, a novel efflux pump inhibitor, apart from inhibiting the MdeA mediated efflux, also significantly inhibit the biofilm formation of S. aureus, boeravinone B may be used in combination with mupirocin for further development. Boeravinone B exh
TN1462	Cajanin 2',4',5-三羟基-7-甲氧基异黄酮,木豆异黄酮	ERK; MEK; Akt	Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Cajanin has potential hypolipidemic effects,possibly via up-regulating the ABCA1 protein expression,subsequently resulting in increased macrophage cholesterol efflux and RCT, it can significantly improve basal glucose uptake in HepG2 cells, its improving effect is concentration dependent, it exhibits effects stronger than that of rosiglitazone, which has been used as an antidiabetic drug.
T79992	Sarglaroids F	Caspase	Apoptosis; Proteases/Proteasome
	Sarglaroids F（化合物6）为从草珊瑚根部提取的抗炎剂，影响K+外排并降低Caspase-1(P20)水平以抑制LPS/ATP诱导的IL-1β释放，对RAW264.7细胞无细胞毒性。
T82339	Gangliotetraose Gg4
	Gangliotetraose（Gg4）是一种含有GM1及其唾液酸化衍生物的四糖。它能促进分化神经元核内Ca2+的外流，进而降低核内Ca2+浓度。Gg4参与调节神经元的可塑性、修复过程以及大脑中神经营养素的释放。
T80001	Majoranaquinone	Antibiotic	Microbiology/Virology
	Majoranaquinone对4种Staphylococcus菌株、1种Moraxella菌株和1种Enterococcus菌株显示出良好的抑菌作用。此外，Majoranaquinone在E.coli ATCC 25922菌株中表现出显著的外排泵抑制活性，并能有效抑制E.coli ATCC 25922和E.coli K-12 AG100的生物膜形成。
TN5474	Bonducellin
	Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bonducellin shows weak antimalarial ac
TN5530	Volkensiflavone Talbotaflavone	Others	Others
	Volkensiflavone (Talbotaflavone) 是一种天然产物，存在于黄芪和藤黄中。它具有植物代谢物的作用,是一种次生代谢产物。Volkensiflavone 是一种双类黄酮，属于羟黄酮和羟黄酮。Volkensiflavone 可以作为佐剂用于过表达外排泵的多药耐药金黄色葡萄球菌的抗生素治疗。

天然产物

Pseudoprotodioscin

Cat.No: T5S0246

Synonym: 山药

Target: Others, Fatty Acid Synthase

Cat.No: T19768

Synonym: gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol,γ-生育三烯酚

Target: Others

6,8-Diprenylnaringenin

Cat.No: TN3150

Synonym: 6,8-二异戊二烯基柚皮素,Senegalensin,Lonchocarpol A

Target: BCRP, ABC

Cat.No: T4818

Synonym: 2-脱氧-D-核糖,2-Deoxy-D-ribose,2-Deoxy-D-arabinose,2-Deoxy-D-erythropentose

Target: Others, Endogenous Metabolite

Cat.No: T8165

Target: Endogenous Metabolite, ABC

Chrysosplenol D

Cat.No: TN1493

Synonym: 猫眼草酚D

Target: IL Receptor, NF-κB, JNK

Cat.No: T6S0095

Synonym: 7-O-Methylapigenin,Puddumetin,Apigenin 7-methyl ether,芫花素

Target: Virus Protease

L-Aspartic aicd sodium

Cat.No: T19554

Synonym: L-Aspartic acid sodium,Sodium L-aspartate

Target: Others, Sodium Channel, Endogenous Metabolite

Alisol F 24-acetate

Cat.No: TMA2270

Target: P-gp

Cat.No: TN2160

Synonym: (-)-Roemerine

Target: Antibiotic

Cat.No: T14140

Synonym: 落叶松蕈酸,Agaricinic Acid

Target: Mitochondrial Metabolism, AChR

Cat.No: T6S0653

Synonym: Buddleoflavonoloside,Buddleoside,Acacetin-7-O-rutinoside,Acaciin,Linarine,蒙花苷

Target: TNF, AChE

Cat.No: TN5466

Cat.No: TN1462

Synonym: 2',4',5-三羟基-7-甲氧基异黄酮,木豆异黄酮

Target: ERK, MEK, Akt

Cat.No: T79992

Target: Caspase

Gangliotetraose

Cat.No: T82339

Synonym: Gg4

Majoranaquinone

Cat.No: T80001

Target: Antibiotic

Cat.No: TN5474

Volkensiflavone

Cat.No: TN5530

Synonym: Talbotaflavone

Target: Others

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