330
14
1
2
88
Cat. No. | Product Name | ||
---|---|---|---|
L4300 | Wnt/Hedgehog/Notch 通路化合物库 | 237 compounds | |
237 个Wnt & Hedgehog & Notch 靶点相关的生物活性小分子化合物的特有集合,用于相关通路的研究及药物的筛选,可用于高通量、高内涵筛选。 |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
CL0141 |
Notch pathway inhibitor kit
Notch pathway inhibitor kit |
||
CL0128 |
HMGCR inhibitor kit
HMGCR inhibitor kit |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4626L |
TC-O 9311
TCO-9311,TC-O9311,TCO 9311,TC-O 9311,TCO9311,TC-O-9311 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
TC-O 9311 (TCO-9311) 是一种孤儿 G 蛋白偶联受体 139 激动剂,EC50值为 39 nM。 | |||
T34793 |
TC-T 6000
TCT 6000,hENT4-IN-1,TCT6000,TC-T6000 |
AChR | Neuroscience |
TC-T 6000 (hENT4-IN-1) 是一种具有选择性和高效性的人源平衡核苷转运蛋白 4 (ENT4) 抑制剂(IC50:74.4 nM),具有血管扩张活性,抑制 hENT1和 hENT2,可用于研究癌症和心血管损伤。 | |||
T8449 |
TC-I2000
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
TC-I2000 是一款 TRPM8 通道阻断器。在表达 rTRPM8 的 CHO 细胞中抑制 icilin 诱导的 TRPM8 通道激活,IC50 为 53 nM。 | |||
T9606 |
TC-067533
|
SARS-CoV | Microbiology/Virology |
TC-067533 是一种类木瓜蛋白酶抑制剂,IC50 为 8.7 μM。 | |||
T17006 |
TC-I 2014
|
TRP/TRPV Channel | Membrane transporter/Ion channel |
TC-I 2014 是一种口服有效的、强效的、苯并咪唑类的、 TRPM8 的拮抗剂,其对犬类、人和大鼠通道的 IC50 值分别为 0.8 nM, 3.0 nM 和 4.4 nM。在疼痛动物模型中具有抗痛觉超敏作用。 | |||
T17009 |
TC-S 7009
|
HIF | Angiogenesis; Chromatin/Epigenetic |
TC-S 7009是一种有效的和具有选择性的HIF-2α抑制剂(Kd: 81 nM)。TC-S 7009对HIF-2α的亲和力大于HIF-1α (Kd >> 5 μM)。 TC-S 7009破坏HIF-2α异源二聚化,降低HIF-2α靶基因表达,降低dna 结合活性。 | |||
T17008 |
TC-S 7005
|
PLK | Cell Cycle/Checkpoint |
TC-S 7005是一种有效的Polo 样激酶的抑制剂,Plk1、Plk2和Plk3的IC50值分别为214 nM,4 nM 和24 nM。 | |||
T13100 |
TC HSD 21
|
Dehydrogenase | Metabolism |
TC HSD 21 是一种有效且高度选择性的 17β-羟基类固醇脱氢酶 3 型抑制剂 (IC50 = 14 nM)。 | |||
T24859 | TC-AQP1-1 | Aquaporin | Membrane transporter/Ion channel |
TC-AQP1-1 是一种通过虚拟筛选鉴定的水通道蛋白 1 通道的阻断剂,并在低微摩尔浓度下抑制非洲爪蟾卵母细胞肿胀试验中通过 hAQP1 的水通量。 | |||
T23439 |
TC-N 1752
|
Sodium Channel | Membrane transporter/Ion channel |
TC-N 1752 是一种具有口服活性的 Nav1.7 通道抑制剂,IC50 为 0.17 μM。 TC-N 1752 显示镇痛活性。 | |||
T13101 |
TC-MCH 7c
|
Melanin-concentrating Hormone Receptor (MCHR) | GPCR/G Protein |
TC-MCH 7c 是一种可口服的、可选择的、可穿透血脑屏障的MCH1R 拮抗剂,其对hMCH1R 的IC50表现为5.6 nM,TC-MCH 7c 是一种苯基吡啶酮衍生物,其对人的MCH1R Ki 分别为 3.4 nM ,对小鼠 MCH1R Ki 为 3.0 nM。 | |||
T17004 |
TC-DAPK 6
|
DAPK | Apoptosis |
TC-DAPK 6 是死亡相关蛋白激酶 (DAPK) 的 ATP 竞争性抑制剂,对 DAPK1 和 DAPK3 的 IC50 分别为 69 和 225 nM。 | |||
T23438 |
TC LPA5 4
|
LPA Receptor | GPCR/G Protein |
TC LPA5 4是LPA5受体的拮抗剂。 | |||
T23440 |
TC-N 22A
|
GluR | Neuroscience |
TC-N 22A 是一种作用力强的、可选择的、口服具有活性的、可以通过血脑屏障的 mGlu4 正向别构调节剂 (PAM)。TC-N 22A 在表达人 mGlu4 的 BHK 细胞中 EC50 表现为 9 nM。TC-N 22A 在激动和正向别构模型中对 mGlu 1、2、3、5 和 7 受体的活性表现很低 (EC50 >10 μM)。TC-N 22A 可以用于中枢神经系统疾病的研究。 | |||
T4648 |
TC-G-1008
GPR39-C3 |
GHSR | GPCR/G Protein |
TC-G-1008 (GPR39-C3) 是一种口服有活性的 GPR39激动剂,可作用于大鼠受体(EC50: 0.4 nM)和人类受体(EC50:0.8 nM)的。 | |||
T21826 |
TC-E 5003
NSC 30176 |
Histone Methyltransferase | Chromatin/Epigenetic |
TC-E 5003 (NSC-30176) 是选择性 PRMT1抑制剂,其 IC50值为1.5 µM。它在 TLR4 信号传导中具有抗炎特性。 | |||
T13099 |
TC ASK 10
|
ASK; MAPK | Apoptosis; MAPK |
TC ASK 10 是选择性的,口服有效的细胞凋亡信号调节激酶 1 抑制剂,IC50为 14 nM。它对其他代表性激酶的抑制活性低于 50%,除 ASK2之外 (IC50为 0.51 μM)。 | |||
T4626 |
TC-O 9311 free base
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
TC-O 9311 是一种有效的 GPR139 激动剂。 | |||
T8818 |
TC-G 1005
(4-环丙基-3,4-二氢-1(2H)-喹喔啉基)[4-(2,5-二甲基苯氧基)-3-吡啶基]甲酮 |
GPCR19 | GPCR/G Protein |
TC-G 1005 是具有口服活性的TGR5选择性激动剂,能够激活 hTGR5 (EC50:0.72 nM)和 mTGR5 (EC50:6.2 nM)。它能够减少小鼠体内葡萄糖水平。 | |||
T28931 |
TC-AC28
TC AC28 |
||
TC-AC28 is a novel potent and selective Brd2(2) ligand. | |||
T23434 |
GPR35 agonist 2
TC-G 1001 |
GPR; Arrestin | Endocrinology/Hormones; GPCR/G Protein |
GPR35 agonist 2 (TC-G 1001) 是一种有效的 GPR35 激动剂。GPR35 agonist 2 在 β-arrestin 和 Ca2+ 释放试验中的 EC50 值分别为 26 和 3.2 nM。 | |||
T27636 |
Ispronicline
AZD-3480,RJR-1734,AZD 3480,TC 1734,AZD3480,TC-01734,TC-1734-112 |
AChR | Neuroscience |
Ispronicline (TC-1734) 是一种具有口服活性、选择性和有效性的 α4β2 nAChR 部分激动剂,具有抗抑郁、神经保护和持久的认知作用。Ispronicline 对 α4β2 nAChR 具有很高的亲和力,Ki= 11 nM。 | |||
T68154 |
TC-2216
|
AChR | Neuroscience |
TC-2216 是神经烟碱乙酰胆碱受体的部分激动剂,可用于治疗焦虑症和抑郁症。 | |||
T26252 |
PI3Kδ-IN-3
TC KHNS 11 |
PI3K | PI3K/Akt/mTOR signaling |
PI3Kδ-IN-3 (TC KHNS 11) 是一种 PI3Kδ 抑制剂,IC50 值为 9 nM。PI3Kδ-IN-3 具有良好的药代动力学特性且对 B 细胞功能有抑制作用。 | |||
T24860 |
TC-G1003
TC G1003 |
||
TC-G1003 is an effective agonist of the somatostatin sst2 receptor. | |||
TQ0110 |
ROCK-IN-2
TC-S 7001,Azaindole 1 |
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
ROCK-IN-2 (Azaindole 1) 是一种选择性,ATP-竞争型的ROCK 抑制剂,对ROCK-1和ROCK-2的IC50值分别为 0.6 和 1.1 nM。 | |||
T70818 |
TC-2153
|
||
TC-2153 是纹状体富集蛋白酪氨酸磷酸酶 (STEP) 的选择性抑制剂,具有精神活性和低急性毒性。TC-2153 增加脑源性神经营养因子 (BDNF) 在大脑中的表达。它还降低MAOA 和5-HT1A receptor 受体的 mRNA 水平。TC-2153 也抑制5-HT2A 受体介导的信号传递。 | |||
T9083 |
TC11
CLT-003,1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 |
BCL; Caspase; CDK | Apoptosis; Cell Cycle/Checkpoint; Proteases/Proteasome |
TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) 是一种有效的肿瘤细胞增殖抑制剂,并通过激活 caspase-3、8 和 9 诱导细胞凋亡。在长时间有丝分裂阻滞期间,它诱导 MCL1降解导致凋亡。它作为苯酞酰亚胺衍生物在结构上与免疫调节药物相关。 | |||
T3193 |
Pimelic diphenylamide 106
Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Pimelic diphenylamide 106 (RGFA-8) 是一种缓慢和紧密结合的I 类HDAC 抑制剂,对HDAC1、 2和3的IC50值分别150、760和370 nM。 | |||
TP2112L |
TC14012 acetate
TC14012 acetate(368874-34-4 free base) |
CXCR; Arrestin | Autophagy; GPCR/G Protein; Immunology/Inflammation |
TC14012 acetate 是 T140 的血清稳定衍生物,是一种选择性的肽模拟 CXCR4 拮抗剂,IC50 为 19.3 nM。 TC14012 还是一种有效的 CXCR7 激动剂,EC50 为 350 nM,可将 β-arrestin 2 募集到 CXCR7。 TC14012 具有抗癌活性和抗 HIV 活性。 | |||
T23424 |
TC 1698 dihydrochloride
|
Others | Others |
nicotinic α7 receptor agonist | |||
T69624 |
TC-5115
|
||
TC-5115 is a potent inhibitor of MLL methyltransferase with IC50 value of 16 nM. TC-5115 may lead to the development of a new therapy for the treatment of human MLL leukemia. The mixed-lineage leukemia (MLL) protein, also known as MLL1, is a lysine methyltransferase specifically responsible for methylation of histone 3 lysine 4. MLL has been pursued as an attractive therapeutic target for the treatment of acute leukemia carrying the MLL fusion gene or MLL leukemia. | |||
T37529 |
TC NTR1 17
|
||
Non-peptide neurotensin receptor 1 (NTS1) partial agonist (EC50 <15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). Exhibits over 50-fold selectivity for NTS1 over NTS2 and GPR35. Hershberger et al (2014) Imidazole-derived agonists for the neurotensin 1 receptor. Bioorg.Med.Chem.Lett. 24 262 PMID:24332089 | |||
T40119 |
TC-2559 difumarate
|
||
TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist with an EC 50 of 0.18 μM. It exhibits selectivity for α4β2 receptors over α2β4, α4β4, and α3β4 receptors, with EC 50 s ranging from 10 to 30 μM. TC-2559 difumarate also demonstrates antinociceptive effects. | |||
T23423 | TC 1 | Others | Others |
σ1 receptor ligand | |||
T33776 |
Ochratoxin TC
|
||
Ochratoxin TC is an ochratoxin C analog. | |||
T23430 |
TC-E 5005
|
Others | Others |
PDE10A inhibitor | |||
T28932 | TC-E 5008 | ||
TC-E 5008 is a selective inhibitor of mutant isocitrate dehydrogenase 1 (mIDH1). | |||
T23435 |
TC-G 1004
|
Others | Others |
adenosine A2A receptors antagonist | |||
T23433 |
TC-G 1000
|
Others | Others |
α2D-adrenoceptor agonist | |||
T17007 |
TC-Mps1-12
|
Kinesin | Cytoskeletal Signaling |
TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) . | |||
T23426 |
TC-A 2317 hydrochloride
|
Others; Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Others |
TC-A 2317 hydrochloride 是 Aurora 激酶 A 的抑制剂,Ki 为 1.2 nM,而 Aurora 激酶 B 的 Ki 为 101 nM。 TC-A 2317 hydrochloride 显示出抗肿瘤活性。 | |||
T23431 |
TC-E 5006
|
Others | Others |
γ-secretase modulator | |||
T23441 |
TC OT 39
|
Others | Others |
oxytocin receptor partial agonist | |||
T23425 |
TC 2559 difumarate
|
Others | Others |
partial agonist of α4β2 nicotinic acetylcholine receptor | |||
T21916 |
TC-SP 14
|
||
TC-SP 14, also known as compound 14, is a highly active and potent S1P1 agonist with oral bioavailability. It exhibits an EC50 value of 0.042 μM, indicating its strong binding affinity to the S1P1 receptor. Notably, its interaction with the S1P3 receptor is minimal, as evidenced by an EC50 value of 3.47 μM. TC-SP 14 demonstrates significant pharmacological effects, including a marked reduction in blood lymphocyte counts and the attenuation of delayed type hypersensitivity response to antigen cha... | |||
T23442 |
TC-P 262
|
Others | Others |
P2X3 and P2X2/3 receptor antagonist | |||
T23428 |
TC-E 5001
|
Others | Others |
dual tankyrase (TNKS) inhibitor | |||
T23427 |
TC-C 14G
|
Others | Others |
CB1 receptor inverse agonist | |||
T23437 |
TC-I 15
|
Others | Others |
α2β1 integrin inhibitor |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TC0017 |
Haplopine
|
Tyrosinase; Antifection | Microbiology/Virology; Proteases/Proteasome |
Haplopine shows photo-activated antimicrobial activity against S. aureus. It exhibits potent melanogenesis-inhibitory activities with almost no toxicity to the cells. | |||
TC0029 |
Peucedanin
|
||
Peucedanin 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TC0029,CAS号为 133-26-6。 | |||
TC0018 |
N-Benzoyl-2-hydroxy-2-phenylethylamine
|
||
N-Benzoyl-2-hydroxy-2-phenylethylamine 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TC0018,CAS号为 111059-46-2。 | |||
TC0037 |
colchiceine
|
||
colchiceine 在生命科学相关研究中具有广泛的应用。 | |||
TN7099 |
antcin A
|
NOD | Immunology/Inflammation; NF-κB |
antcin A 是一种类固醇类植物化学物质,从珍贵的食用菌牛樟芝子实体中分离出来,具有很强的抗炎和抗肿瘤作用。 | |||
T2916 |
Patchouli alcohol
百秋李醇,Patchouli camphor,Patchoulol,(-)-Patchouli Alcohol,广藿香醇 |
Antibacterial; Antifungal | Microbiology/Virology |
Patchouli alcohol (Patchoulol) 是一种从广藿香中提取的天然三环倍半萜,有抗幽门螺杆菌和抗炎活性。 | |||
T75614 | Kouitchenside G | ||
Kouitchenside G 是一种可以从Swertia kouitchensis 中分离得到的天然产物。Kouitchenside G 抑制α-Glucosidase,IC50为 956 μM。 | |||
T68351 |
Homodestcardin
|
||
Homodestcardin is a cyclic depsipeptide fungal metabolite that has been found in T. roseum and has immunosuppressant activity. It inhibits concanavalin A-induced proliferation of isolated mouse T cells. | |||
T80688 |
β-Patchoulene
|
||
β-Patchoulene, 一种三环倍半萜类化合物,源自广藿香油,主要应用于炎症性疾病治疗。 | |||
T80010 |
(25S)-Antcin B
|
SARS-CoV | Microbiology/Virology |
Antcin-B是3CLPro的高亲和力有效抑制剂,可用于SARS-CoV-2的研究。 | |||
TMA2549 |
Sutchuenmedin A
|
Others | Others |
Sutchuenmedin A is a natural product from Epimedium sutchuenense. | |||
T3427 |
Polydatin
Piceid,虎杖苷,Polydotin Peceid |
Apoptosis; Mitophagy; NF-κB; Autophagy | Apoptosis; Autophagy; NF-κB |
Polydatin (Piceid) 是从传统中药虎杖根中提取的一种天然产物,在多个实验模型中具有抗炎作用。它可抑制 G6PD,并诱导氧化和内质网应激。 | |||
TL0012 |
Shyobunone
|
Others | Others |
Shyobunone and isoshyobunone have insecticidal and repellant activity, they exhibit strong contact toxicity against Lasioderma serricorne (LS adults with LD50 values of 20.24 and 24.19 ug/adult, respectively; they are strongly repellent against Tribolium | |||
T83111 |
Angulatin E
|
||
Angulatin E为celangulin TC制备过程中的关键活性成分。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01003 |
TCN2 Protein, Human, Recombinant (His)
II,TC-2,D22S750,TC,TCII,TC |
Human | HEK293 Cells |
TCN2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.7 kDa and the accession number is P20062-1. | |||
TMPY-03484 |
TCPTP Protein, Human, Recombinant
TCPTP,protein tyrosine phosphatase, non-receptor ty... |
Human | Baculovirus Insect Cells |
TCPTP Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 36.8 kDa and the accession number is P17706-1. | |||
TMPK-00550 |
CD55/DAF Protein, Cynomolgus, Recombinant (His)
TC,DAF-GPI,CR,CROM,Daf1,CD55,Cd55a,DAF |
Cynomolgus | HEK293 Cells |
Decay Accelerating Factor (or CD55) is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection. | |||
TMPY-02369 |
TCPTP Protein, Mouse, Recombinant (aa 2-314, His)
protein tyrosine phosphatase, non-receptor type 2,TC |
Mouse | Baculovirus Insect Cells |
TCPTP Protein, Mouse, Recombinant (aa 2-314, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 38.7 kDa and the accession number is Q06180-1. | |||
TMPY-00713 |
CD55/DAF Protein, Human, Recombinant (hFc)
CR,CD55 molecule, decay accelerating factor for complement (... |
Human | HEK293 Cells |
CD55/DAF Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.7 kDa and the accession number is P08174-1. | |||
TMPY-02173 |
TCPTP Protein, Human, Recombinant (aa 1-314, His & GST)
TCPTP,TC-PTP,protein tyrosine phosphatase,... |
Human | Baculovirus Insect Cells |
TCPTP Protein, Human, Recombinant (aa 1-314, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 64.4 kDa and the accession number is P17706-1. | |||
TMPY-01292 |
CD55/DAF Protein, Human, Recombinant (His)
CD55 molecule, decay accelerating factor for complement (Cro... |
Human | HEK293 Cells |
CD55/DAF Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.5 kDa and the accession number is P08174-1. | |||
TMPY-01187 |
Rac1 Protein, Human, Recombinant (GST)
Rac-1,p21-Rac1,MIG5,ras-related C3 botulinum toxin substrate... |
Human | Baculovirus Insect Cells |
RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for RAC1 gene. RAC1 is a plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, bind... | |||
TMPY-00469 |
CXCL7 Protein, Human, Recombinant (His)
LA-PF4,TC1,LDGF,NAP-2,TGB,CTAP-III,PBP,Beta-TG,CTAP... |
Human | E. coli |
CXCL7 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 9.9 kDa and the accession number is P02775. | |||
TMPY-05081 |
Notch 1 Protein, Human, Recombinant (hFc)
notch 1,TAN1,hN1,AOVD1,AOS5 |
Human | HEK293 Cells |
Notch 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79.7 kDa and the accession number is P46531. | |||
TMPY-05054 |
Notch 4 Protein, Human, Recombinant (His)
INT3,notch 4 |
Human | Baculovirus Insect Cells |
NOTCH4 (Notch Receptor 4) is a Protein Coding gene. Notch4 belongs to a family of transmembrane receptors that play an important role in vascular development and maintenance. The NOTCH4 gene is located at 6p21.3 and is involved in the development and patterning of the central nervous systems. It regulates signaling pathways associated with neuronal maturation, a process involved in the development and patterning of the central nervous system. The NOTCH4 gene has also been identified as a possibl... | |||
TMPY-00856 |
TCCR Protein, Human, Recombinant (hFc)
WSX1,interleukin 27 receptor, α,IL27R,TCCR,IL-27RA,... |
Human | HEK293 Cells |
TCCR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 79 kDa and the accession number is Q6UWB1. | |||
TMPK-00356 |
IL-27RA/TCCR Protein, Human, Recombinant (His)
WSX1,IL-27 RA,IL27R α,CRL1,IL27RA,IL27R alpha,IL-27R-alpha,W... |
Human | HEK293 Cells |
IL-27Ra (also known as TCCR and WSX1) as a gene whose expression can induce the transformation of hematopoietic cells. IL-27Ra (IL-27R) is a type I cytokine receptor that functions as the ligand binding component of the receptor for IL-27 and functions with the glycoprotein 130 (gp130) coreceptor to induce signal transduction in response to IL-27. | |||
TMPK-00066 |
BCMA/TNFRSF17 Protein, Human, Recombinant (His & Avi), FITC-Labeled
CD269,TNFRSF17,TNFRSF13A,BCMA,BCM |
Human | HEK293 Cells |
B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene.TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). BCMA/TNFRSF17 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 8.9 kDa and the accession number is Q0222... | |||
TMPJ-01452 |
Notch 1 Protein, Mouse, Recombinant (aa 18-526, His)
mT14,Neurogenic locus notch homolog protein 1,Mo |
Mouse | HEK293 Cells |
Mouse Notch1 is a 300 kDa type I transmembrane glycoprotein and it functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Mouse Notch1 is synthesized as a 2531 amino acid (aa) precursor that contains an 18 aa signal sequence, a 1707 aa extracellular domain (ECD) with 36 EGFlike repeats and three Lin12/notch repeats, a 21 aa transmembrane segment and a 785 aa cytoplasmic domain that contains six ankyrin repeats, a glutamine-rich domain ... | |||
TMPK-00465 |
Notch 2 Protein, Human, Recombinant (His & Avi)
N2,Notch-2,HJCYS,AGS2,NOTCH2,N2ECD |
Human | HEK293 Cells |
Human Notch 2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch 2 is lethal, showing that not all functions overlap.Notch 2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intrac... | |||
TMPK-01367 |
Notch 3 Protein, Human, Recombinant (His & Avi), Biotinylated
Notch-3,Notch homolog 3,CADASIL,NOTC |
Human | HEK293 Cells |
Notch 3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 47.7 kDa and the accession number is Q9UM47. | |||
TMPH-01946 |
PTCH2 Protein, Human, Recombinant (His & Myc)
|
Human | E. coli |
PTCH2 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPK-00822 |
VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled
RP1-261G23.1,VEGFA,MGC70609,VEGF,VEGFMGC70609,VPF,VAS,MVCD1,... |
Human | HEK293 Cells |
Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF165 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 22.2 kDa and the accession number is P15692-4. | |||
TMPY-05571 |
Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated
CD33 molecule,Siglec-3,p67,SIGLEC3 |
Human | HEK293 Cells |
Siglec-3/CD33 Protein, Human, Recombinant, FITC conjugated is expressed in HEK293 mammalian cells. The accession number is AAH28152.1. | |||
TMPH-02216 |
TCN1 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach. | |||
TMPJ-00058 |
BTC Protein, Mouse, Recombinant (His)
βcellulin,isoform CRA_a,Btc,Betacellulin,mCG_12529 |
Mouse | E. coli |
Mouse Betacellulin is a single type I membrane protein which belongs to the EGF family of cytokines. EGF family has many members including EGF, TGF-a, Amphiregulin, HB-EGF, Epiregulin, Tomoregulin and the Neuregulins. Betacellulin is characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. Betacellulin is expressed in several tissues and tumor cells including kidney, uterus, liver, pancreas and small intestine.... | |||
TMPK-00466 |
Notch 2 Protein, Human, Recombinant (His & Avi), Biotinylated
NOTCH2,N2,N2ECD,Notch-2,HJCYS,AGS2 |
Human | HEK293 Cells |
Human Notch-2 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes. Although Notch proteins are structurally and functionally similar, deletion of either Notch-1 or Notch-2 is lethal, showing that not all functions overlap.Notch-2 functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intrac... | |||
TMPK-00107 |
NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag), FITC-Labeled
NKG2D,KLR,CD314,D12S2489E,NKG2-D |
Human | HEK293 Cells |
NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain. This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands. Human NKG2D is expressed on CD8 alpha beta T cells, gamma δ T cells, NK cells and NKT cells. NKG2D/CD314 Protein, Human, Recombinant (hFc & Flag), FITC-Labeled is expressed in HEK293 mammalian cells with N-hFc-Flag tag. The predicted molecular weight is 43.4 kDa and the a... | |||
TMPH-00672 |
Metalloprotease stcE Protein, E. coli O157:H7, Recombinant (His)
|
E. coli | E. coli |
Virulence factor that contributes to intimate adherence of enterohemorrhagic E.coli (EHEC) O157:H7 to host cells. Is able to cleave the secreted human mucin 7 (MUC7) and the glycoprotein 340 (DMBT1/GP340). Also cleaves human C1 inhibitor (SERPING1), a regulator of multiple inflammatory pathways, and binds and localizes it to bacterial and host cell surfaces, protecting them from complement-mediated lysis. Therefore, the current model proposes two roles for StcE during infection: it acts first as... | |||
TMPK-01005 |
CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His), FITC-Labeled
DCAL-2,HECL,CLL-1,CLECSF7,CD371,CLEC12A,PRO34150,MICL,CLECSF... |
Human | HEK293 Cells |
CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (His), FITC-La... | |||
TMPY-05028 |
NOTCH2NL Protein, Human, Recombinant (mFc)
notch 2 N-terminal like,N2N |
Human | HEK293 Cells |
NOTCH2NLA (Notch 2 N-Terminal Like A) is a Protein Coding gene. NOTCH2NL, human-specific paralogs of the NOTCH2 receptor, stood out for their ability to promote cortical progenitor maintenance. It belongs to the NOTCH family. NOTCH2NL promote the clonal expansion of human cortical progenitors, ultimately leading to higher neuronal output. At the molecular level, NOTCH2NL function by activating the Notch pathway through inhibition of cis Delta/Notch interactions. NOTCH2NL ectopic expression delay... | |||
TMPK-01360 |
Notch 3 Protein, Human, Recombinant (His & Avi)
Notch-3,Notch homolog 3,NOTCH3,CA... |
Human | HEK293 Cells |
Notch 3 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 47.7 kDa and the accession number is Q9UM47. | |||
TMPH-03645 |
Alpha-TCS Protein, Trichosanthes kirilowii, Recombinant (His)
rRNA N-glycosidase,EC:3.2.2.22,Ribosome-inactivating protein... |
Trichosanthes kirilowii | E. coli |
Inactivates eukaryotic 60S ribosomal subunits. Alpha-TCS Protein, Trichosanthes kirilowii, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P09989. | |||
TMPK-00452 |
HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled
LCCS2,HER3c-erbB-3,p180-ErbB3,MGC88033,ErbB3,p85-sErbB3,p45-... |
Human | HEK293 Cells |
Her3, also called ErbB3, is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors.Her3 is expressed in keratinocytes, melanocytes, skeletal muscle cells, embryonic myoblasts and Schwann cells. Monomeric Her3 serves as a low affinity receptor for the heregulins (HRG). HER3/ERBB3 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 71.6 kDa and the accession numbe... | |||
TMPK-00270 |
TPBG/5T4 Protein, Human, Recombinant (His & Avi), FITC-Labeled
WAIF1,TPBG,5T4AG,5T4,M6P1 |
Human | HEK293 Cells |
The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR4/CXCL12, Wnt, and Hippo pathways which may all contribute through the mobilization of CSCs. TPBG/5T4 Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 38.2 kDa and the accession numb... | |||
TMPJ-00986 |
CTCF Protein, Human, Recombinant
Transcriptional Repressor CTCF,CCCTC-Bindi... |
Human | E. coli |
Transcriptional Repressor CTCF (CTCF) belongs to the CTCF Zinc-Finger Protein family. CTCF contains twelve C2H2-type zinc fingers and interacts with CHD8. CTCF is widely expressed in many tissues, and it is absent in primary spermatocytes. CTCF is involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. CTCF plays an essential role in oocyte and preimplantation embryo development by activating or rep... | |||
TMPH-01783 |
NOTCH2NLB Protein, Human, Recombinant (His & Myc)
|
Human | Baculovirus Insect Cells |
NOTCH2NLB Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 31.3 kDa and the accession number is P0DPK3. | |||
TMPH-02944 |
TCTP/TPT1 Protein, Mouse, Recombinant (His)
|
Mouse | E. coli |
Involved in calcium binding and microtubule stabilization. TCTP/TPT1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.5 kDa and the accession number is P63028. | |||
TMPH-01784 |
NOTCH2NLB Protein, Human, Recombinant (E. coli, His & Myc)
|
Human | E. coli |
NOTCH2NLB Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.9 kDa and the accession number is P0DPK3. | |||
TMPJ-01344 |
TCblR Protein, Human, Recombinant (hFc)
8D6 antigen,CD320 antigen,Transcobalamin receptor,TC |
Human | HEK293 Cells |
TCblR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 58-60 KDa and the accession number is Q9NPF0. | |||
TMPJ-01345 |
TCblR Protein, Human, Recombinant (His)
FDC-signaling molecule 8D6,CD320,8D6 antigen,Transcobalamin ... |
Human | HEK293 Cells |
TCblR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 32-58 KDa and the accession number is Q9NPF0. | |||
TMPY-05906 |
Influenza A H1N1 (A/swine/Saskatchewan/SD0056/2014) Hemagglutinin/HA Protein (His)
Harvey rat sarcoma viral oncogene homolog |
H1N1 | HEK293 Cells |
Influenza A H1N1 (A/swine/Saskatchewan/SD0056/2014) Hemagglutinin/HA Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.5 kDa and the accession number is A0A0U4T2C2. | |||
TMPH-03528 |
Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS47), Recombinant (His & Myc)
chp,Chemotaxis inhibitory protein,CHIPS |
Staphylococcus aureus | E. coli |
Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of human neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fMLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fMLP-induced calcium responses. Prevents phagocytosis of the bacterium. Chemotaxis inhibitory Protein, S. aureus (strain NCTC 8325/PS... | |||
TMPY-03889 |
STC2 Protein, Human, Recombinant (His)
stanniocalcin 2,STC-2,STCRP |
Human | HEK293 Cells |
STC2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.1 kDa and the accession number is O76061. | |||
TMPY-05543 |
TCCR Protein, Mouse, Recombinant (His)
Tccr,Wsx1,CRL1,WSX-1,interleukin 27 receptor, alpha... |
Mouse | HEK293 Cells |
TCCR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.6 kDa and the accession number is AAC40121.1. | |||
TMPY-00371 |
STC1 Protein, Human, Recombinant (His)
stanniocalcin 1,STC |
Human | HEK293 Cells |
Stanniocalcin-1 (STC1) is a paracrine factor associated with inflammation and carcinogenesis. STC1 is a secreted glycoprotein hormone and involved in various types of human malignancies. Stanniocalcin-1 (STC1), which has myriad functions, including the maintenance of calcium homeostasis, the promotion of early wound healing, uncoupling respiration (aerobic glycolysis), reepithelialization in damaged tissues, the inhibition of vascular leakage, and the regulation of macrophage functions to keep e... | |||
TMPY-03279 |
STC2 Protein, Human, Recombinant (hFc)
STC-2,STCRP,stanniocalcin 2 |
Human | HEK293 Cells |
STC2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.7 kDa and the accession number is O76061. | |||
TMPY-06792 |
TCCR Protein, Mouse, Recombinant (His & Avi), Biotinylated
Tccr,CRL1,IL-27R,interleukin 27 receptor, α,Wsx1,in... |
Mouse | HEK293 Cells |
TCCR Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 56.37 kDa and the accession number is AAC40121.1. | |||
TMPK-00961 |
MSLN/Mesothelin Protein, Human, Recombinant (His & Avi), FITC-Labeled
MSLN,MPF,CAK1,Mesothelin,MPFSMRP,SMR |
Human | HEK293 Cells |
MSLN/Mesothelin Protein, Human, Recombinant (His & Avi), FITC-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 35.2 kDa and the accession number is Q13421-2. | |||
TMPH-02911 |
STC2 Protein, Mouse, Recombinant
|
Mouse | E. coli |
Has an anti-hypocalcemic action on calcium and phosphate homeostasis. STC2 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 30.1 kDa and the accession number is O88452. | |||
TMPK-01016 |
B7-H3 Protein, Human, Recombinant (hFc), FITC-Labeled
B7H3, UNQ309,PRO352,PSEC0249,B7 homolog 3,B7-H3,CD276 |
Human | HEK293 Cells |
B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction. B7-H3 Protein, Human, Recombinant (hFc), FITC-Labeled is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular w... | |||
TMPK-01471 |
HLA-A*11:01&B2M&KRAS WT (VVVGAGGVGK) Monomer Protein, Human, MHC (His & Avi), FITC-Labeled
CFC2,KRAS,K-RAS4B,MHC,K-RAS2B,KRAS1,NS3,K-RAS2A,NS,K-RAS4A,R... |
Human | HEK293 Cells |
Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. | |||
TMPH-00606 |
CDTC Protein, E. coli, Recombinant (His & Myc)
Cytolethal distending toxin subunit C,CDT C,CDTC |
E. coli | E. coli |
Part of the tripartite complex that is required for the CDT activity. CdtC, along with CdtA, probably forms a heterodimeric subunit required for the delivery of CdtB. CDTC Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.7 kDa and the accession number is Q46670. | |||
TMPY-04930 |
Notch 2 Protein, Human, Recombinant (His)
AGS2,HJCYS,hN2,notch 2 |
Human | Baculovirus Insect Cells |
NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of developmental processes by controlling cell fate decisions. Hajdu Cheney Syndrome (HCS) is a rare disease associated with mutations of NOTCH2 that lead to the translation of a truncated, presumably stable, NOTCH2 protein. NOTCH2 is down-regulated in colon cancer, and reduced express... | |||
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