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Search Results for " rankl "

Targets Recommended: RANKL/RANK Others

22

抑制剂 & 化合物

20

天然产物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7844	4-IPP 4-Iodo-6-phenylpyrimidine	Others	Others
	4-IPP (4-Iodo-6-phenylpyrimidine) 是一种巨噬细胞迁移抑制因子 (MIF) 的特异性自杀底物，也是 MIF 的不可逆抑制剂。
T9917	Denosumab	RANKL/RANK	NF-κB
	Denosumab 是能够结合并抑制RANKL 受体激活因子的人单克隆抗体。它具有抗癌活性，可降髋部、低椎骨以及非椎骨骨折的风险。
T16159	Muramyl dipeptide MDP	NOD	Immunology/Inflammation; NF-κB
	Muramyl dipeptide (MDP) 是合成的免疫反应肽，由 N-乙酰壁酸与 L-Ala-D-isoGln 的短氨基酸链相连。它通过MAPK 途径上调 Runx2 基因表达，直接促进成骨细胞分化，通过降低 RANKL/OPG 比值间接抑制破骨细胞分化。它是通过Runx2诱导骨形成的诱导因子，也是NLRP1激动剂。
T13324	VUF11207 fumarate	CXCR; Arrestin	Autophagy; GPCR/G Protein; Immunology/Inflammation
	VUF11207 fumarate 是一种 CXCR7激动剂和高效CXCR7配体，pKi 为 8.1。它可诱导CXCR7的β-arrestin2募集和随后的内在化，pEC50分别为 8.8 和 7.9。
T62189	sRANKL-IN-1
	sRANKL-IN-1 (compound S3) 是一种 sRANKL (soluble RANKL) 的抑制剂。sRANKL-IN-1 能够较强的抑制破骨细胞 (IC50: 0.096 μM，Kd: 34.80 μM)。sRANKL-IN-1 能够用于研究骨质疏松症。
T61531	NFATc1-IN-1	RANKL/RANK	NF-κB
	NFATc1-IN-1 (also known as compound A04) is a highly effective inhibitor of osteoclast formation induced by RANKL, with an IC50 of 1.57 μM. It exerts its anti-osteoclastogenic effects by attenuating the RANKL-induced nuclear translocation of NFATc1. Due to its remarkable properties, NFATc1-IN-1 holds significant potential for advancing research related to osteoclastic diseases [1].
T15718	Latanoprost acid	GPR	Endocrinology/Hormones; GPCR/G Protein
	Latanoprost acid 是前列腺素受体的选择性激动剂，通过抑制 c-fos/NFATc1 通路抑制 RANKL 诱导的破骨细胞生成和功能。拉坦前列素酸可用于降低眼内压力的研究。
T77567	BCPA	Others	Others
	BCPA 是一种无细胞毒性的 Pin1 调节剂。BCPA 可调节破骨细胞活化，减弱 Pin1 蛋白的减少，从而抑制 RANKL 诱导的破骨细胞发生的受体激活物。BCPA 用于研究骨质疏松。
T2188	Thonzonium Bromide 嘧苯十六铵,通佐溴胺	Proton pump; Antibacterial; Autophagy	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Thonzonium bromide 是一种单阳离子表面活性剂，在结构上与 Farnesol 相似的抗菌剂。它以剂量依赖的方式抑制质子转运 (EC50=69 μM)。在体外可抑制 RANKL 诱导的破骨细胞形成和骨吸收，并在体内阻止 LPS 诱导的骨丢失。
T27526	Halenaquinone
	Halenaquinone is a phosphatidylinositol 3-kinase inhibitor. Halenaquinone specifically inhibits the secondary DNA binding of RAD51. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Halenaquinone induces apoptosis in PC12 cells.
T72008	E09241
	E09241 is a novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through canonical Wnt/β-catenin signaling.
T71479	Kahweol oleate
	Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T68642	Kahweol palmitate
	Kahweol palmitate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T80618	Narlumosbart	RANKL/RANK	NF-κB
	Narlumosbart（JMT103）是一种IgG4κ型抗体，专一性靶向核因子-κB 配体受体激活剂（RANKL）。
T69205	GGTI-2166
	GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent monocytes (MD cells) and the mouse monocyte cell line RAW 264.7 (RAW cells). GGTI-2166 inhibited TRAP activity induced by RANKL or TNF-alpha in both cell cultures and prevented the incorporation of [3H]all-trans geranylgeraniol into prenylated proteins in RAW cells.
T73061	Amakusamine
	Amakusamine以IC50值为10.5 μM，抑制NF-κB配体受体激活剂(RANKL)在RAW264.7细胞中诱导的多核破骨细胞形成。
T71480	Kahweol linoleate
	Kahweol linoleate is a semi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T81171	SH491
	SH491（Compound 33）是一款抗骨质疏松药物。该化合物能够抑制RANKL诱导的骨髓源性单核细胞（BMM）分化为破骨细胞（IC50: 11.8 nM）。同时，SH491降低了破骨细胞形成的相关标记基因（TRAP、CTSK、MMP-9和ATPase v0d2）以及相应蛋白（TRAP、CTSK、MMP-9）的表达。
T71478	Kahweol stearate
	Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T68641	Kahweol Acetate
	Kahweol Acetate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
T78816	Anti-osteoporosis agent-4	NF-κB	NF-κB
	Anti-osteoporosis agent-4 (Compound 11h) 在生物医学领域中表现为有效抑制原代破骨细胞的分化，减弱RANKL诱导的破骨细胞生成，并展示出强抑制作用，具有 IC50 值为358.29 nM。此外，该化合物还能抑制关键的 PI3K/AKT 和 IκBα/NF-κB 信号通路激活，表明其在防治骨质疏松症中的潜在应用价值。
T19848	Cyclosporin B 7-L-Alanine-cyclosporin A,Antibiotic S 7481F2
	Cyclosporin B is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. Cyclosporin B displays antiviral properties, inhibiting the entry of hepatitis B into hepatocytes. Cyclosporin B also

化合物

Cat.No: T7844

Synonym: 4-Iodo-6-phenylpyrimidine

Target: Others

Cat.No: T9917

Target: RANKL/RANK

Muramyl dipeptide

Cat.No: T16159

Synonym: MDP

Target: NOD

VUF11207 fumarate

Cat.No: T13324

Target: CXCR, Arrestin

Cat.No: T62189

Cat.No: T61531

Target: RANKL/RANK

Latanoprost acid

Cat.No: T15718

Target: GPR

Cat.No: T77567

Target: Others

Thonzonium Bromide

Cat.No: T2188

Synonym: 嘧苯十六铵,通佐溴胺

Target: Proton pump, Antibacterial, Autophagy

Cat.No: T27526

Cat.No: T72008

Cat.No: T71479

Kahweol palmitate

Cat.No: T68642

Cat.No: T80618

Target: RANKL/RANK

Cat.No: T69205

Cat.No: T73061

Kahweol linoleate

Cat.No: T71480

Cat.No: T81171

Kahweol stearate

Cat.No: T71478

Kahweol Acetate

Cat.No: T68641

Anti-osteoporosis agent-4

Cat.No: T78816

Target: NF-κB

Cat.No: T19848

Synonym: 7-L-Alanine-cyclosporin A,Antibiotic S 7481F2

Cat. No.	Product Name	Target	Signaling Pathways
T5528	Cyanidin Chloride	Antioxidant	oxidation-reduction
	Cyanidin Chloride 是一种花青素的亚类，具有抗氧化和抗癌活性。它能够抑制破骨细胞形成，羟基磷灰石吸收和 NF-κB 配体 (RANKL) 诱导的破骨细胞标记基因表达的受体激活。
T0683	Mevastatin Compactin,ML236B,美伐他汀	Apoptosis; Antibacterial; Antibiotic; HMG-CoA Reductase; Autophagy; Lipid	Apoptosis; Autophagy; Metabolism; Microbiology/Virology
	Mevastatin (ML236B) 是他汀类 HMG-CoA 还原酶抑制剂。它是一种降脂药，可诱导细胞凋亡，将癌细胞阻滞在 G0/G1期。它还可增加内皮型一氧化氮合酶的 mRNA 和蛋白质水平。它有抗肿瘤活性，用于心血管疾病的研究。
T2789	Scutellarin 黄岑素,野黄芩苷,Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide	Akt; HIV Protease; STAT	Cytoskeletal Signaling; JAK/STAT signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Scutellarin (Scutellarein-7-glucuronide) 是从黄芩中分离的黄酮，可抑制破骨细胞中 RANKL 介导的 MAPK 和 NF-κB 信号通路，并下调 HCC 细胞中的 STAT3/Girdin/Akt 信号通路。
TN1215	(2S)-2'-Methoxykurarinone 2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone	Akt; Antifection	Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
	(2S)-2'-Methoxykurarinone 是一种分离自苦参根中的化合物，具有抗炎、解热、抗糖尿病和抗肿瘤活性。它对人髓系白血病 HL-60 细胞具有细胞毒活性。它能够下调 RANKL 信号，抑制破骨细胞形成和骨吸收。
TN2143	3,7,4'-Trihydroxyflavone Resokaempferol,5-Deoxykampferol	DNA	DNA Damage/DNA Repair
	3,7,4'-Trihydroxyflavone(5-Deoxykampferol) 是从黄檀心材中分离得到的一种具有 DNA 断链活性的黄酮类化合物，可抑制 NF-κB 配体（RANKL）受体激活剂诱导的 RAW 264.7 细胞和骨髓巨噬细胞中的破骨细胞分化、肌动蛋白环形成和骨吸收。
T5770	Alisol B	RANKL/RANK	NF-κB
	Alisol B 是一种具有用于骨科疾病研究潜力的化合物，通过分化破骨细胞发挥其功能。
T6S0923	Hypericin Hypericine,金丝桃素,Cyclosan	Apoptosis; Antiviral; Influenza Virus; Tyrosine Kinases; Antibacterial; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Hypericin (Cyclosan) 是贯叶连翘的提取物，有抗菌、抗病毒、抗肿瘤和抗抑郁作用。
T3849	Kinsenoside 金线莲苷,(+)-Kinsenoside	Apoptosis; Nrf2	Apoptosis; Immunology/Inflammation
	Kinsenoside ((+)-Kinsenoside) 是从金盏花属植物中分离得到的主要活性成分，以 Nrf2 依赖的方式保护髓核细胞在氧化应激下的生存能力，防止细胞凋亡、衰老和线粒体功能障碍。它显示出显着的抗肝毒性和抗炎活性。
T2755	Rhoifolin 野漆树苷,Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside	Others; p38 MAPK; NF-κB; transporter; IGF-1R; Autophagy	Autophagy; MAPK; Metabolism; NF-κB; Others; Tyrosine Kinase/Adaptors
	Rhoifolin (Apigenin 7-O-neohesperidoside) 是从琯溪蜜柚叶子分离的一种黄酮糖苷。它通过 RANKL 诱导的NF-κB 和MAPK 途径改善钛颗粒刺激的骨溶解并减少破骨细胞生成。它通过增强脂联素分泌，胰岛素受体-β的酪氨酸磷酸化和GLUT4易位有助于治疗糖尿病并发症。
TN1712	Gossypin	NF-κB; S6 Kinase	MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Gossypin 是一种从Hibiscus vitifolius 中分离得到的黄酮，能够抑制NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中，它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。
T5720	Boldine 1,10-Dimethoxy-2,9-dihydroxyaporphine,波尔定碱,波尔定,ex Peumus boldus	RANKL/RANK	NF-κB
	Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) 是一种阿扑吗啡异喹啉生物碱，从山苍子根中提取获得，具有抗氧化、抗炎和细胞保护的活性。它能够抑制破骨细胞生成，并利用下调 OPG/RANKL/RANK 信号途径，改善骨破坏。它可用于研究类风湿性关节炎。
T5S2129	Sciadopitysin	TNF; NF-κB	Apoptosis; NF-κB
	Sciadopitysin 是一种双黄酮类化合物，来自银杏叶片中。它通过抑制NF-κB 活化并降低c-Fos 和NFATc1的表达来抑制 RANKL 诱导的破骨细胞生成和骨丢失。
TN3209	3′,4′,7-Trihydroxyflavone	ATPase; Others; p38 MAPK; NF-κB	MAPK; Membrane transporter/Ion channel; NF-κB; Others
	3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。
T38799	2,3-Bis(3-indolylmethyl)indole
	2,3-Bis(3-indolylmethyl)indole exhibits concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption.
T83151	Ajudecunoid A
	Ajudecunoid A, 一种从Ajuga decumbens分离的天然产物，具有抑制RANKL诱导的破骨细胞生成的活性。
T27711	Kahweol Eicosanate J002075,J 002075,J-002075
	Kahweol Eicosanate is a semi-syntetic derivative of kahweol. Kahweol Eicosanate exhibits a wide variety of biological activities, including inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, inhibiting RANKL-induced osteoclast
T83033	Anti-osteoporosis agent-2
	Anti-osteoporosis agent-2 (Compound 10)为抗骨质疏松剂，能抑制RANKL诱导的破骨细胞分化。
T16846	Sauristolactam Saurolactam	Others	Others
	Sauristolactam inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation. Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus Chi
T79932	Eudebeiolide B Plebeiolide D	NF-κB	NF-κB
	Eudebeiolide B，一种自荔枝草分离得的化合物，能通过调控RANKL诱导的NF-κB、c-Fos及钙信号来抑制破骨细胞的生成，适用于研究与破骨细胞相关的疾病。
TN2775	2-Methoxystypandrone	MMP; BCL; IκB/IKK; GSK-3; TNF; NOS; NF-κB; Wnt/beta-catenin; COX; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity. 2-Methoxystypandrone concomitant

天然产物

Cyanidin Chloride

Cat.No: T5528

Target: Antioxidant

Cat.No: T0683

Synonym: Compactin,ML236B,美伐他汀

Target: Apoptosis, Antibacterial, Antibiotic, HMG-CoA Reductase, Autophagy, Lipid

Cat.No: T2789

Synonym: 黄岑素,野黄芩苷,Breviscapin,Breviscapinun,Breviscapine,Scutellarein-7-glucuronide

Target: Akt, HIV Protease, STAT

(2S)-2'-Methoxykurarinone

Cat.No: TN1215

Synonym: 2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone

Target: Akt, Antifection

3,7,4'-Trihydroxyflavone

Cat.No: TN2143

Synonym: Resokaempferol,5-Deoxykampferol

Target: DNA

Cat.No: T5770

Target: RANKL/RANK

Cat.No: T6S0923

Synonym: Hypericine,金丝桃素,Cyclosan

Target: Apoptosis, Antiviral, Influenza Virus, Tyrosine Kinases, Antibacterial, PKC

Cat.No: T3849

Synonym: 金线莲苷,(+)-Kinsenoside

Target: Apoptosis, Nrf2

Cat.No: T2755

Synonym: 野漆树苷,Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside

Target: Others, p38 MAPK, NF-κB, transporter, IGF-1R, Autophagy

Cat.No: TN1712

Target: NF-κB, S6 Kinase

Cat.No: T5720

Synonym: 1,10-Dimethoxy-2,9-dihydroxyaporphine,波尔定碱,波尔定,ex Peumus boldus

Target: RANKL/RANK

Cat.No: T5S2129

Target: TNF, NF-κB

3′,4′,7-Trihydroxyflavone

Cat.No: TN3209

Target: ATPase, Others, p38 MAPK, NF-κB

2,3-Bis(3-indolylmethyl)indole

Cat.No: T38799

Cat.No: T83151

Kahweol Eicosanate

Cat.No: T27711

Synonym: J002075,J 002075,J-002075

Anti-osteoporosis agent-2

Cat.No: T83033

Cat.No: T16846

Synonym: Saurolactam

Target: Others

Cat.No: T79932

Synonym: Plebeiolide D

Target: NF-κB

2-Methoxystypandrone

Cat.No: TN2775

Target: MMP, BCL, IκB/IKK, GSK-3, TNF, NOS, NF-κB, Wnt/beta-catenin, COX, JAK, STAT

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02726	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc) RANKL,OPGL,Trance,OPG,tumor necrosis factor (ligand...	Mouse	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 56 kDa and the accession number is AAC40113.1.
TMPY-03364	RANKL/TNFSF11/CD254 Protein, Human, Recombinant sOdf,OPTB2,TNFSF11,TRANCE,hRANKL2,ODF,OPGL,RANK...	Human	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 20.5 kDa and the accession number is AAC51762.1.
TMPY-03674	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc) sOdf,tumor necrosis factor (ligand) superfamily, member 11,T...	Human	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 52.4 kDa and the accession number is AAC51762.1.
TMPJ-00607	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) Receptor activator of nuclear factor κ-B ligand,Osteoprotege...	Mouse	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 30-35 KDa and the accession number is BAA97257.1.
TMPK-00717	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His & Flag) OPGL,CD254,TRANCE,ODF,RANKL,TNFSF11,OPTB2,sOdf	Human	HEK293 Cells
	Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL and RANK are under the tight control of the female sex hormones estradiol and progesterone. RANKL/TNFSF11/CD254 Protein, Human, Recombinant ...
TMPK-00591	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (aa 70-316, His) CD254,OPGL,TNFSF11,TRANCE,ODF,sOdf,OPTB2,RANKL	Mouse	HEK293 Cells
	Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL and RANK are under the tight control of the female sex hormones estradiol and progesterone. RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant ...
TMPY-01471	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (hFc) TRANCE,sOdf,CD254,hRANKL2,TNFSF11,ODF,OPTB2,tumor n...	Human	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is AAC51762.1.
TMPK-00716	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244) OPGL,TRANCE,OPTB2,TNFSF11,ODF,sOdf,RANKL,CD254	Human	HEK293 Cells
	Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL and RANK are under the tight control of the female sex hormones estradiol and progesterone. RANKL/TNFSF11/CD254 Protein, Human, Recombinant ...
TMPY-06561	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (rFc) OPTB2,OPGL,hRANKL2,CD254,sOdf,tumor necrosis factor...	Human	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 46.18 kDa and the accession number is AAC51762.1.
TMPJ-00662	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) Receptor activator of nuclear factor kappa-B ligand,Receptor...	Human	E. coli
	CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitog...
TMPY-03527	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc) CD254,tumor necrosis factor (ligand) superfamily, member 11,...	Human	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc) is expressed in HEK293 mammalian cells with rFc tag. The predicted molecular weight is 47.9 kDa and the accession number is O14788-2.
TMPY-00537	RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc) tumor necrosis factor (ligand) superfamily, member 11	Cynomolgus	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 48.9 kDa and the accession number is G7PW41.
TMPJ-01472	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)	Mouse	HEK293 Cells
	RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 23-29 KDa and the accession number is O35235-1.
TMPJ-01466	Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His) OPG,Tumor Necrosis Factor Receptor Superfamily Member 11B,OC...	Human	HEK293 Cells
	TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNF...
TMPJ-00674	RANK/TNFRSF11A Protein, Mouse, Recombinant (His) Receptor activator of NF-KB,TNFRSF11A,Osteoclast differentia...	Mouse	HEK293 Cells
	Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, br...
TMPJ-00349	RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His) CD265 antigen,FEO,TRANCER,ODFR,ODFROSTS,TRANCE R,TNFRSF11A,O...	Human	HEK293 Cells
	Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutive...
TMPH-02659	FPR2 Protein, Mouse, Recombinant (GST & His & Myc)	Mouse	E. coli
	High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophil chemotactic factors. Stimulates chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation. Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation. FPR2 Protein, Mouse,...
TMPJ-00253	OPG Protein, Mouse, Recombinant (His) Opg,Ocif,Tnfrsf11b,Osteoclastogenesis inhibitory factor,Oste...	Mouse	HEK293 Cells
	Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG ...

重组蛋白

RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-02726

Species: Mouse

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Human, Recombinant

Cat.No: TMPY-03364

Species: Human

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03674

Species: Human

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00607

Species: Mouse

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPK-00717

Species: Human

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (aa 70-316, His)

Cat.No: TMPK-00591

Species: Mouse

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01471

Species: Human

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244)

Cat.No: TMPK-00716

Species: Human

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (rFc)

Cat.No: TMPY-06561

Species: Human

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)

Cat.No: TMPJ-00662

Species: Human

Expression System: E. coli

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (aa 63-244, rFc)

Cat.No: TMPY-03527

Species: Human

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPY-00537

Species: Cynomolgus

Expression System: HEK293 Cells

RANKL/TNFSF11/CD254 Protein, Mouse, Recombinant (Flag & His)

Cat.No: TMPJ-01472

Species: Mouse

Expression System: HEK293 Cells

Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)

Cat.No: TMPJ-01466

Species: Human

Expression System: HEK293 Cells

RANK/TNFRSF11A Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00674

Species: Mouse

Expression System: HEK293 Cells

RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)

Cat.No: TMPJ-00349

Species: Human

Expression System: HEK293 Cells

FPR2 Protein, Mouse, Recombinant (GST & His & Myc)

Cat.No: TMPH-02659

Species: Mouse

Expression System: E. coli

OPG Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00253

Species: Mouse

Expression System: HEK293 Cells

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