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Search Results for " phosphatidylinositol "

76

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TQ0009	UCB9608	PI4K	PI3K/Akt/mTOR signaling
	UCB9608 是选择性、可口服的 PI4KIIIβ 抑制剂，IC50=11 nM，对其选择性高于 PI3KC2 α，β 和 γ。它能够增加代谢稳定性，具有良好的药代动力学特征，是一种免疫抑制剂。
T27499	GSK-A1	HCV Protease; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	GSK-A1 是 III 型磷脂酰肌醇 4-激酶 PI4KA 选择性抑制剂，pIC50为 8.5-9.8，抑制 PtdIns(4,5)P2 再合成，IC50约为 3 nM。GSK-A1有效降低 PtdIns(4)P 的水平，而对 PtdIns(4,5)P2 没影响。GSK-A1在抗丙型肝炎病毒方面有研究的潜力。
T13386	Zandelisib	PI3K	PI3K/Akt/mTOR signaling
	Zandelisib 是PI3K 抑制剂，对p110δ选择性抑制，IC50为 3.5 nM。它显示出抗肿瘤作用。
T16125	MMV390048	Parasite; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling
	MMV390048 是一种抗疟药，是一种新型化学疟原虫 PI4K 抑制剂。它与疟原虫 PI4K 的 ATP 结合位点结合，不与除人类 PIP4K2C 外的其他恶性疟原虫和人类激酶结合。
T16967	T-00127_HEV1	PI4K	PI3K/Akt/mTOR signaling
	T-00127_HEV1 是有效的phosphatidylinositol 4-kinase III beta 抑制剂，IC50为 60 nM。
T12454	PI-273	Apoptosis; PI4K	Apoptosis; PI3K/Akt/mTOR signaling
	PI-273 是一种可逆的特异性磷脂酰肌醇 4-激酶抑制剂，IC50为 0.47 μM。它可抑制乳腺癌细胞的增殖，阻断细胞周期并诱导细胞凋亡。
T16530	BF738735	Antiviral; PI4K	Immunology/Inflammation; PI3K/Akt/mTOR signaling
	BF738735 是有效的磷脂酰肌醇 4-激酶 IIIβ 抑制剂，IC50为 5.7 nM。
T5421	KDU691	Parasite; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling
	KDU691 是一种咪唑吡嗪类药物，对血阶段的裂殖体、配子体和肝期具有较强的抗寄生虫活性，它是 PI4K 抑制剂，选择性抑制双氢青蒿素预处理的恶性疟原虫。
T12468	PI4KIIIbeta-IN-10	PI3K; PI4K	PI3K/Akt/mTOR signaling
	PI4KIIIbeta-IN-10 是PI4KIIIβ抑制剂，IC50=3.6 nM。
T2616	PIK-93 PIK 93	ATM/ATR; DNA-PK; Virus Protease; PI3K; Carbonic Anhydrase; PI4K; mTOR; HSV	DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
	PIK-93 是一种合成的PI4KIIIβ抑制剂，IC50值为 19 nM，同时可抑制PI3Kγ和PI3Kα的活性，IC50值分别为 16 nM 和 39 nM。
T12469	PI4KIIIbeta-IN-9	PI3K; PI4K	PI3K/Akt/mTOR signaling
	PI4KIIIbeta-IN-9 是一种 PI4KIIIβ抑制剂，其 IC50=7 nM。它也抑制 PI3Kδ (IC50:125 nM) 和 PI3Kγ (IC50:1046 nM)。
T4220	BQR-695 BQR695,NVP-BQR695	PI3K; Parasite; PI4K	Microbiology/Virology; PI3K/Akt/mTOR signaling
	BQR-695 (NVP-BQR695) 是一种磷脂酰肌醇 4-激酶抑制剂，对于人类和疟原虫 PI4KIIIβ 的 IC50值分别为 80 和 3.5 nM。
T19840	GSK-F1 PI4KA inhibitor-F1	PI4K	PI3K/Akt/mTOR signaling
	GSK-F1 (PI4KA inhibitor-F1) 是一种新型强效 PI4KA 抑制剂。
T4079	LY-294002 hydrochloride SF 1101,LY 294002,NSC 697286	PI3K	PI3K/Akt/mTOR signaling
	LY-294002 hydrochloride (NSC 697286) 是一种合成的 PI3Kα/δ/β 分子抑制剂（IC50：0.5/0.57/0.97 μM，在无细胞试验中）；在溶液中比 Wortmannin 更稳定，也是自噬体形成的阻断剂。
T41270	Phosphatidylinositols, soya, sodium salts
	Phosphatidylinositols, soya, sodium salts 在生命科学相关研究中具有广泛的应用。
T77212	L-α-lysophosphatidylinositol (Soy) (sodium)
	L-α-lysophosphatidylinositol Soy sodium 作为GPR55的内源性配体，是一种既属于内源性溶血磷脂也是内源性大麻素神经递质的化合物。
T28416	PIK-108 PIK 108,PIK108	PI3K	PI3K/Akt/mTOR signaling
	PIK-108 是选择性的、变构的、非 ATP 竞争性的 p110β/p110δ 抑制剂。
T2061	APY0201	PI3K; Interleukin	Immunology/Inflammation; PI3K/Akt/mTOR signaling
	APY0201 是PIKfyve 抑制剂，能够抑制 PtdIns3P 转化为PtdIns(3,5)P2 (IC50:5.2 nM)，还能够抑制IL-12/IL-23产生。
T26195	SMI481 NPPM-6748-481,NPPM 6748-481,NPPM6748481,SMI-481 SMI 481,NPPM 6748481	Others	Others
	SMI481 (NPPM6748481) 是一种选择性的酵母磷脂酰肌醇转移蛋白 (PITP) Sec14 抑制剂。
T67837	(3S)-GSK-F1 PI4KA inhibitor-F1	PI4K	PI3K/Akt/mTOR signaling
	(3S)-GSK-F1是一种选择性PI4KIIIα抑制剂，pIC50=8.3。
T3556	NIH-12848	PI3K	PI3K/Akt/mTOR signaling
	NIH12848 是推定的磷脂酰肌醇 5-磷酸4-激酶 γ (PI5P4Kγ) 抑制剂(IC50:1 μM)。
T12365	PARP/PI3K-IN-1	PARP; PI3K	Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	PARP/PI3K-IN-1 是一种新型双重聚（ADP-核糖）聚合酶(PARP）和磷酸肌醇 3-激酶(PI3K)双重抑制剂，具有抗癌、抗肿瘤和抗癌细胞增殖活性，可用于研究乳腺癌、胰腺癌和肺癌。
T26698	AZ044	PI4K	PI3K/Akt/mTOR signaling
	AZ044是 III 型磷脂酰肌醇-4-激酶α -亚型(PI4KIIIalpha)的有效选择性抑制剂。
T16528	PI-828 LY 294002, 4gamma-NH2	Casein Kinase; PI3K	Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	PI-828 是磷脂酰肌醇3-激酶(PI3K)抑制剂，广泛用于研究 PI3K 的生理功能，也可促进干细胞向中胚层分化。
T1861	Omipalisib GSK458,GSK2126458	PI3K; mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	Omipalisib (GSK2126458) 是一种磷脂酰肌醇 3-激酶(PI3K) 的小分子吡啶磺酰胺抑制剂，具有抗肿瘤活性。它抑制 p110α/β/δ/γ，mTORC1/2 的活性，Ki 值分别为 0.019 nM/0.13 nM/0.024 nM/0.06 nM 和 0.18 nM/0.3 nM。
T6168	ZSTK474	PI3K; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	ZSTK474 是 ATP 竞争性的泛 I 类PI3K 抑制剂，抑制 PI3Kα、PI3Kβ、PI3Kδ 和 PI3Kγ，IC50分别为 16 nM、44 nM、4.6 nM 和 49 nM。它是一种可口服的 s-三嗪衍生物，具有抗肿瘤活性。
T1999	Taselisib RG-7604,GDC-0032	PI3K; Carbonic Anhydrase	Metabolism; PI3K/Akt/mTOR signaling
	Taselisib (GDC-0032) 是 PI3K 抑制剂，靶向作用于突变 PI3KCA。它能够抑制 PI3Kα (IC50:0.29 nM)，PI3Kβ (IC50:0.91 nM) 和 PI3Kγ (IC50:0.97 nM)。
T67845	ARUK2001607	PI3K	PI3K/Akt/mTOR signaling
	ARUK2001607 是磷脂酰肌醇 5-磷酸 4-激酶 γ (PI5P4Kγ) 的选择性抑制剂，Kd 为 7.1 nM。ARUK2001607 对PI5P4Kγ的选择性超过其他 >150 种激酶。
T13623	Compound 48/80 trihydrochloride C48/80 trihydrochloride	Phospholipase	Metabolism
	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) 是 N-甲基对甲氧基苯乙胺和甲醛发生缩合反应后的混合物。Compound 48/80 trihydrochloride 是一种肥大细胞 (mast cell) 脱颗粒剂和组胺 (histamine) 释放剂。Compound 48/80 trihydrochloride 对人血小板磷脂酰肌醇特异性磷脂酶 C (phosphatidylinositol-specific phospholipase C) 活性有抑制作用。
T27094	CT-2584 CT2584
	CT-2584 is an angiogenesis inhibitor and lysophosphatidic acid acyltransferase inhibitor. CT-2584 inhibits phospholipid signaling. By inhibiting CTP:choline-phosphate cytidylyltransferase (CT), CT-2584 caused de novo phospholipid biosynthesis via PA to be
T68130	Pobilukast SKF 104353 Z2,SKF 104353	Leukotriene Receptor	GPCR/G Protein
	Pobilukast (SKF 104353) 是一种选择性半胱氨酰白三烯受体拮抗剂，可阻断磷脂酰肌醇代谢和白三烯D诱导的血栓素合成，可用于研究过度心肌再灌注损伤（MI/R）大鼠限制心肌损伤。
T2370	AC-55541 AOB2796	Proteasome; Protease-activated Receptor	GPCR/G Protein; Proteases/Proteasome; Ubiquitination
	AC-55541 (AOB2796) 是高选择性的蛋白酶激活受体 2(PAR2)激动剂，pEC50为6.7。它在 PI 水解测定和 Ca2+动态测定中的pEC50值为 5.9 和 6.6，在体内表现出伤害感受器活性。
T72032	PI5P4Ks-IN-2	PI3K	PI3K/Akt/mTOR signaling
	PI5P4Ks-IN-2 是磷脂酰肌醇 5-磷酸 4-激酶 PI5P4Kγ 的抑制剂。PI5P4Ks-IN-2 靶向 PI5P4K 亚型，对 PI5P4Kα、PI5P4Kβ、PI5P4Kγ和PI5P4Kγ+具有抑制作用，IC50 值分别 <4.3、<4.6、6.2和0.32 。
T67703	mTOR inhibitor 9b	mTOR	PI3K/Akt/mTOR signaling
	mTOR inhibitor 9b 是一种酶抑制剂，对蛋白激酶mTOR 和磷脂酰肌醇 3-激酶 PIK3CA 具有抑制作用，IC50分别为 0.76nm 和1.262 µM。mTOR inhibitor 9b 具有抗癌活性，可用来研究白血病、皮肤癌、乳腺癌、肺癌和结肠癌。
T36083	DS-7423	PI3K; mTOR	PI3K/Akt/mTOR signaling
	DS-7423 是PI3K 和mTOR 的有效抑制剂，抑制PI3Kα 和 mTOR 的IC50分别为15.6 nM 和 34.9 nM。DS-7423表现出抗癌活性。
T67702	mTOR inhibitor 9d	PI3K; mTOR	PI3K/Akt/mTOR signaling
	mTOR inhibitor 9d 是一种蛋白激酶 mTOR 和PI3K 双重抑制剂，对mTOR 的IC50值为0.31nm，可用于治疗白血病、皮肤癌、乳腺癌、肺癌和结肠癌。
T32950	Lumi-PI
	Lumi-PI is used as a chemiluminescent substrate for detecting phosphatidylinositol-specific phospholipase C.
T69912	AS2541019
	AS2541019 is a selective Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibitor.
T39581	PI3K-IN-19 hydrochloride PI3K-IN-19 hydrochloride
	PI3K-IN-19 hydrochloride (WO2017153220, step 5) acts as a phosphatidylinositol-3-kinase (PI3K) inhibitor.
T22759	Edelfosine	Others	Others
	inhibits phosphatidylinositol phospholipase C
T24637	PI3K inhibitor C 96 PI3K IN C96,PI3K-IN-C96
	PI3K inhibitor C 96 is an inhibitor of phosphatidylinositol 3-kinase. It shows effective activity against multiple myeloma in vitro and in vivo.
T71798	Demethoxyviridiol
	Demethoxyviridiol is a mycotoxin that inhibits phosphatidylinositol 3-kinase (PI3K).
T27526	Halenaquinone
	Halenaquinone is a phosphatidylinositol 3-kinase inhibitor. Halenaquinone specifically inhibits the secondary DNA binding of RAD51. Halenaquinone inhibits RANKL-induced osteoclastogenesis. Halenaquinone induces apoptosis in PC12 cells.
T28627	RV-1729 RV1729
	RV-1729, a phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) inhibitor, is used potentially for the treatment of asthma.
T29159	WJD008 WJD-008,WJD 008
	WJD008 is a dual inhibitor of phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin. WJD008 prevents PI3K signaling and inhibits the proliferation of transformed cells with oncogenic PI3K mutant. WJD008 has antiproliferative and anticlonogeni
TP1977	187-1, N-WASP inhibitor
	Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization
T37030	PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt) PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4)-P1 (1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) featuring C8:0 fatty acids at the sn-1 and sn-2 positions. The compound contains the same inositol and diacylglycerol (DAG) stereochemistry as the natural compound. PtdIns-(4)-P1 can be phosphorylated to di- ...
T27157	Dezapelisib INCB-040093,INCB 040093,INCB040093
	Dezapelisib is an orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K). INCB040093 prevents both the production of the second messenger phosphatidylinositol-3,4,5-trisp
T36937	PtdIns-(1,2-dioctanoyl) (sodium salt)
	The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) containing C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this anal...
T4186	AC-264613 AC264613	Protease-activated Receptor	GPCR/G Protein
	AC-264613 是一种选择性蛋白酶激活受体 (PAR-2) 激动剂，pEC50为 7.5。

化合物

Cat.No: TQ0009

Target: PI4K

Cat.No: T27499

Target: HCV Protease, PI4K

Cat.No: T13386

Target: PI3K

Cat.No: T16125

Target: Parasite, PI4K

Cat.No: T16967

Target: PI4K

Cat.No: T12454

Target: Apoptosis, PI4K

Cat.No: T16530

Target: Antiviral, PI4K

Cat.No: T5421

Target: Parasite, PI4K

PI4KIIIbeta-IN-10

Cat.No: T12468

Target: PI3K, PI4K

Cat.No: T2616

Synonym: PIK 93

Target: ATM/ATR, DNA-PK, Virus Protease, PI3K, Carbonic Anhydrase, PI4K, mTOR, HSV

PI4KIIIbeta-IN-9

Cat.No: T12469

Target: PI3K, PI4K

Cat.No: T4220

Synonym: BQR695,NVP-BQR695

Target: PI3K, Parasite, PI4K

Cat.No: T19840

Synonym: PI4KA inhibitor-F1

Target: PI4K

LY-294002 hydrochloride

Cat.No: T4079

Synonym: SF 1101,LY 294002,NSC 697286

Target: PI3K

Phosphatidylinositols, soya, sodium salts

Cat.No: T41270

L-α-lysophosphatidylinositol (Soy) (sodium)

Cat.No: T77212

Cat.No: T28416

Synonym: PIK 108,PIK108

Target: PI3K

Cat.No: T2061

Target: PI3K, Interleukin

Cat.No: T26195

Synonym: NPPM-6748-481,NPPM 6748-481,NPPM6748481,SMI-481 SMI 481,NPPM 6748481

Target: Others

Cat.No: T67837

Synonym: PI4KA inhibitor-F1

Target: PI4K

Cat.No: T3556

Target: PI3K

Cat.No: T12365

Target: PARP, PI3K

Cat.No: T26698

Target: PI4K

Cat.No: T16528

Synonym: LY 294002, 4gamma-NH2

Target: Casein Kinase, PI3K

Cat.No: T1861

Synonym: GSK458,GSK2126458

Target: PI3K, mTOR, Autophagy

Cat.No: T6168

Target: PI3K, Autophagy

Cat.No: T1999

Synonym: RG-7604,GDC-0032

Target: PI3K, Carbonic Anhydrase

Cat.No: T67845

Target: PI3K

Compound 48/80 trihydrochloride

Cat.No: T13623

Synonym: C48/80 trihydrochloride

Target: Phospholipase

Cat.No: T27094

Synonym: CT2584

Cat.No: T68130

Synonym: SKF 104353 Z2,SKF 104353

Target: Leukotriene Receptor

Cat.No: T2370

Synonym: AOB2796

Target: Proteasome, Protease-activated Receptor

Cat.No: T72032

Target: PI3K

mTOR inhibitor 9b

Cat.No: T67703

Target: mTOR

Cat.No: T36083

Target: PI3K, mTOR

mTOR inhibitor 9d

Cat.No: T67702

Target: PI3K, mTOR

Cat.No: T32950

Cat.No: T69912

PI3K-IN-19 hydrochloride

Cat.No: T39581

Synonym: PI3K-IN-19 hydrochloride

Cat.No: T22759

Target: Others

PI3K inhibitor C 96

Cat.No: T24637

Synonym: PI3K IN C96,PI3K-IN-C96

Demethoxyviridiol

Cat.No: T71798

Cat.No: T27526

Cat.No: T28627

Synonym: RV1729

Cat.No: T29159

Synonym: WJD-008,WJD 008

187-1, N-WASP inhibitor

Cat.No: TP1977

PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)

Cat.No: T37030

Synonym: PtdIns-(4)-P1 (1,2-dioctanoyl) (ammonium salt)

Cat.No: T27157

Synonym: INCB-040093,INCB 040093,INCB040093

PtdIns-(1,2-dioctanoyl) (sodium salt)

Cat.No: T36937

Cat.No: T4186

Synonym: AC264613

Target: Protease-activated Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T73812	Phosphatidylinositol 4,5-bisphosphate
	Phosphatidylinositol 4,5-bisphosphate（L-alpha-Phosphatidylinositol-4,5-bisphosphate）为细胞膜磷脂成分，主要作为磷脂酶C（PLC）与磷酸肌醇3-激酶（PI3K）的底物，充当重要信使。
T3399	Psoralidin	Others; Estrogen/progestogen Receptor; Reactive Oxygen Species; Lipoxygenase; Gamma-secretase; Akt; COX; Antibacterial	Cytoskeletal Signaling; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Psoralidin 是COX-2和5-LOX 的抑制剂，有抗癌，抗菌和抗炎作用。它显著下调NOTCH1信号传导，还极大地诱导活化氧产生。
TN2019	Orobol 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮	BCL; Caspase; PI3K	Apoptosis; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) 是酪氨酸特异性蛋白激酶和磷脂酰肌醇转换的抑制剂。Orobol 抑制 PI3K，对 PI3K α/β/γ/K/δ 的 IC50 为 3.46-5.27 μM。 Orobol 具有抗皮肤老化和抗肥胖的作用。
T4S21320	ISOGINKGETIN 异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮	MMP; Others	Others; Proteases/Proteasome
	ISOGINKGETIN (4',4'''-Dimethylamentoflavone) 是一种MMP9抑制剂，也是一种Pre-mRNA Splicing 抑制剂。
TMA0291	Dehydroglyasperin D	GSK-3; p38 MAPK; ROS; Akt; COX; PI3K; DNA/RNA Synthesis; Prostaglandin Receptor; JNK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells
	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction with phosphatidylinositol 3-kinase; it also mediates suppression of both COX-2 expression and the MLK3 signalling pathway through direct binding and inhibition of MLK3. Dehydroglyasperin D shows strong ferric reducing activities and effectively scavenged DPPH, ABTS(+), and singlet o...

天然产物

Phosphatidylinositol 4,5-bisphosphate

Cat.No: T73812

Cat.No: T3399

Target: Others, Estrogen/progestogen Receptor, Reactive Oxygen Species, Lipoxygenase, Gamma-secretase, Akt, COX, Antibacterial

Cat.No: TN2019

Synonym: 3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮

Target: BCL, Caspase, PI3K

Cat.No: T4S21320

Synonym: 异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮

Target: MMP, Others

Dehydroglyasperin D

Cat.No: TMA0291

Target: GSK-3, p38 MAPK, ROS, Akt, COX, PI3K, DNA/RNA Synthesis, Prostaglandin Receptor, JNK

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