Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PI-828 是磷脂酰肌醇3-激酶(PI3K)抑制剂,广泛用于研究 PI3K 的生理功能,也可促进干细胞向中胚层分化。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,160 | 现货 | ||
5 mg | ¥ 2,890 | 现货 | ||
10 mg | ¥ 4,280 | 现货 | ||
25 mg | ¥ 6,850 | 现货 | ||
50 mg | ¥ 9,270 | 现货 | ||
100 mg | ¥ 12,500 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,980 | 现货 |
产品描述 | PI-828 is a phosphatidylinositol 3-kinase (PI3K) inhibitor, which is widely used to study the physiological function of PI3K and also promotes stem cell differentiation into mesoderm. |
靶点活性 | CK2:149 nM, p110α:173 nM, CK2α2:1.127 μM |
体外活性 | PI-828 (0.78-3.12 µM; 48 hours) reduces caspase 3 activation. However, higher concentrations of PI-828 (6.25-12.5 μM) alone causes apoptosis[2].The sensitivity to PI-828 is a key feature of PI3K-C2β that shows a different sensitivity to this inhibitor compared to class I PI3Ks. Of note, 1 μM PI-828 has no effect on the activity of PI3K-C2β, while it significantly inhibits class I PI3Ks. In particular, a concentration of 10 μM PI-828 completely blocks class I PI3Ks, whereas it has only a partial inhibitory effect on PI3K-C2β[4] |
别名 | LY 294002, 4gamma-NH2 |
分子量 | 322.36 |
分子式 | C19H18N2O3 |
CAS No. | 942289-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11.2 mg/mL (34.9 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.1021 mL | 15.5106 mL | 31.0212 mL | 77.553 mL |
5 mM | 0.6204 mL | 3.1021 mL | 6.2042 mL | 15.5106 mL | |
10 mM | 0.3102 mL | 1.5511 mL | 3.1021 mL | 7.7553 mL | |
20 mM | 0.1551 mL | 0.7755 mL | 1.5511 mL | 3.8777 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PI-828 942289-87-4 Metabolism PI3K/Akt/mTOR signaling Stem Cells PI3K Casein Kinase LY 294002, 4gamma-NH2 PI 828 LY-294002, 4gamma-NH2 PI828 Inhibitor inhibitor inhibit