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49

抑制剂 & 化合物

38

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7356	PTP1B-IN-1 PTP1B inhibitor,5-苯基-1,2,5-噻二唑烷-3-酮 1,1-二氧化物	Phosphatase	Metabolism
	PTP1B-IN-1 (PTP1B inhibitor) 是一种蛋白质酪氨酸磷酸酶 1B 的有效抑制剂 (IC50 : 1.6 mM)
T12577	PTP1B-IN-3	Phosphatase	Metabolism
	PTP1B-IN-3 是一种具有有选择性和高效性的 PTP1B 抑制剂，具有抗癌活性，抑制 PTP1B 和 TCPTP 。PTP1B-IN-3 可用于研究糖尿病。
T67893	PTP1B-IN-22	Phosphatase	Metabolism
	PTP1B-IN-22是一种蛋白酪氨酸磷酸酶1B (PTP1B)抑制剂，可抑制骨骼肌 L6肌管的葡萄糖摄取。
T4256	PTP1B-IN-2	Phosphatase	Metabolism
	PTP1B-IN-2 是一种蛋白酪氨酸磷酸酶抑制剂，IC50=50 nM。
T24073	PTP1B-IN-4 NUN 17724,PTP1B-inhibitor-2,PTP1B IN 2,PTP1B-IN-2,PTP1B-inhibitor-4,FRJ,PTP1B inhibitor 4,NUN17724,PTP1B inhibitor 2,PTP1BIN2,NUN-17724	Phosphatase	Metabolism
	PTP1B-IN-4 (NUN-17724)是一种 PTP1B 的变构抑制剂，IC50为8μM。PTP1B-IN-4可用于肥胖症和糖尿病的研究。
T12578	(E,E)-RAMB4 PTP1B-IN-8	Phosphatase	Metabolism
	PTP1B-IN-8 is a potent and selective inhibitor of protein tyrosine phosphatase-1B (PTP1B).
T12579	RAMB4 PTP1B-IN-9	Proteasome	Proteases/Proteasome; Ubiquitination
	RAMB4 (PTP1B-IN-9) 是一种泛素-蛋白酶体系统(UPS)应激源，是通过抑制 20S 蛋白酶体催化活性物质上游泛素介导的蛋白质降解而产生。它能够在不影响 20S 蛋白酶体催化活性的情况下触发泛素蛋白酶体系统 (UPS) 应激反应。
T40745	PTP1B-IN-13 PTP1B-IN-13
	PTP1B-IN-13, a potent and selective inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B), effectively targets the allosteric site, exhibiting an IC50 value of 1.59 μM.
T40835	PTP1B-IN-14 PTP1B-IN-14
	PTP1B-IN-14 is a selective PTP1B inhibitor ( IC 50 = 0.72 μM) targeting the allosteric site.
T63739	PTP1B-IN-15
	PTP1B-IN-15 是有效的、选择性的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂，对II 型糖尿病和肥胖症表现出研究潜力。
T61851	PTP1B-IN-3 diammonium
	PTP1B-IN-3 diammonium is a highly effective and orally bioavailable inhibitor of the protein tyrosine phosphatase 1B (PTP1B) enzyme, with an IC50 value of 120 nM for both PTP1B and TCPTP. This compound exhibits potent antidiabetic and anticancer properties, as supported by extensive research [1] [2].
T78703	PTP1B/AKR1B1-IN-2	Phosphatase	Metabolism
	PTP1B/AKR1B1-IN-2（化合物7f）是一种双重PTP1B/AKR1B1抑制剂，具有IC50：3.2和2.1 μM，Ki：4.0和0.9μM。该化合物作为胰岛素模拟剂，能够改善小鼠C2C12肌母细胞的葡萄糖摄取，并可用于2型糖尿病（T2DM）的研究。
T63022	PTP1B-IN-18
	PTP1B-IN-18 是一种口服具有活力的完全混合型蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂 (Ki: 35.2 μM)。PTP1B-IN-18 能够用于研究 2 型糖尿病。
T63435	PTP1B-IN-16
	PTP1B-IN-16 是有潜力的、选择性的苯并咪唑衍生物，也是一种蛋白质酪氨酸磷酸酶 1B (PTP1B) 抑制剂 (Ki: 12.6 μM)。PTP1B-IN-16 能够用于研究 2 型糖尿病。
T63021	PTP1B-IN-17
	PTP1B-IN-17 (Compound 45) 是一种有潜力的选择性苯并咪唑衍生物，能够作为蛋白质酪氨酸磷酸酶 1B (PTP1B) 抑制剂 (Ki: 30.2 μM)。PTP1B-IN-17 能够用于研究 2 型糖尿病。
T78702	PTP1B/AKR1B1-IN-1	Phosphatase	Metabolism
	PTP1B/AKR1B1-IN-1是一种针对PTP1B和AKR1B1的双重抑制剂，其IC50值分别为0.06 μM和4.3 μM。该化合物也能抑制TC-PTP，IC50为9 μM。在小鼠成肌细胞中，PTP1B/AKR1B1-IN-1作为胰岛素模拟剂使用，并能减少AKR1B1依赖的山梨醇积累，有助于抑制2型糖尿病的发展并控制血糖水平。
T63023	PTP1B-IN-19
	PTP1B-IN-19 (Compound 43) 是一种有潜力的选择性苯并咪唑衍生物，能够作为蛋白质酪氨酸磷酸酶 1B (PTP1B) 抑制剂 (Ki: 23.3 μM)。PTP1B-IN-17 能够用于研究 2 型糖尿病。
T4340	SPI-112	Phosphatase	Metabolism
	SPI 112 是一种选择性的、有效的、竞争性的SHP2 (PTPN11)抑制剂，对SHP2，蛋白酪氨酸磷酸酶 (PTP) 和 PTP1B 的IC50分别为 1 μM，18.3 μM 和 14.5 μM。
T23133	Pentamidine	Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology
	Pentamidine 是抗微生物剂，会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究，有抗肿瘤活性，抗菌活性。
T28410	PHPS1 PHPS-1,PHPS 1	Phosphatase	Metabolism
	PHPS1 是 Shp2的选择性抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的 Ki 分别为 0.73，5.8，10.7，5.8 和 0.47 μM。
T9921	Infliximab	TNF	Apoptosis
	Infliximab 是一种与 TNF-α特异性结合的嵌合单克隆 IgG1 抗体，可阻止 TNF-α与 TNFR1和 TNFR2 的相互作用，用于治疗克罗恩病和类风湿性关节炎。
T7704	KY-226	Phosphatase	Metabolism
	KY-226 是选择性的，口服活性的和变构蛋白酪氨酸磷酸酶 1B 抑制剂，IC50=0.25 μM，且不激活 PPARγ 。它可以保护神经元免受脑缺血损伤。它通过增强胰岛素和瘦素信号传导发挥抗糖尿病和抗肥胖作用。
T1654	Pentamidine isethionate Pentamidine isethionate salt,Pentamidine diisethionate,喷他脒羟乙磺酸盐	Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology
	Pentamidine isethionate (Pentamidine diisethionate) 是抗微生物剂，会干扰 DNA 的生物合成。它抑制寄生虫Leishmania infantum，IC50为 2.5 μM。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它有抗肿瘤和抗菌活性。
T23132	Pentamidine dihydrochloride 喷他脒二盐酸盐,MP-601205 dihydrochloride	Phosphatase; Antibacterial; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology
	Pentamidine dihydrochloride (MP-601205 dihydrochloride) 是一种抗微生物剂，会干扰 DNA 的生物合成。它是选择性蛋白酪氨酸磷酸酶和再生肝磷酸酶抑制剂。它可用于冈比亚锥虫病，抗锑利什曼病和卡氏肺孢子虫肺炎的研究，有抗肿瘤活性，抗菌活性。
T22276	Bis(maltolato)oxovanadium(IV) 双(麦芽醇)氧钒(IV),BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)	Phosphatase; Others	Metabolism; Others
	Bis(maltolato)oxovanadium(IV) (BMOV) 是一种有效的胰岛素增敏剂，也是一种有效的、竞争性的、可逆的、口服具有活性的光谱蛋白酪氨酸磷酸酶 (PTP) 抑制剂。它抑制HCPTPA，PTP1B，HPTPβ和SHP2的IC50分别为 126 nM，109 nM，26 nM 和 201 nM。
T7381	TCS 401	Phosphatase	Metabolism
	TCS 401 是一种选择性的蛋白酪氨酸磷酸酶 1B 抑制剂。
T7084	2-Bromo-4'-hydroxyacetophenone SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮	Phosphatase	Metabolism
	2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) 是一种PTP1B 的有效抑制剂，其Ki=42 μM。
T9938	RA371 EX-A4742	Others	Others
	RA371 (EX-A4742) 是 PTP1B-IN-8 的衍生物，PTP1B-IN-8 是 PTP1B 的抑制剂。
T4627	SPI--112Me	Others	Others
	SPI--112Me 是 SPI-112 的前药，在无细胞试验中，它优先抑制 Shp2 的 PTPase 活性超过 Shp1 和 PTP1B 20 倍。
T22137	PTP Inhibitor IV	Others	Others
	PTP Inhibitor IV 是一种有效的蛋白酪氨酸磷酸酶 (PTP) 抑制剂，可选择性抑制 DUSP14 磷酸酶活性（IC50 ： 5.21 μM）。PTP Inhibitor IV 对 SHP-2、PTP1B、PTP-ε、PTP Meg-2、PTP-σ、PTP-β 和 PTP-μ具有抑制作用，IC50 分别为 1.8 μM、2.5 μM、8.4 μM、13 μM、20 μM、6.4 μM，和 6.7 μM。PTP Inhibitor IV 通过抑制PTP 活性，影响细胞信号传导，并可能调节与PTP 介导的信号传导事件相关的特定途径。
T13013	Sodium stibogluconate Stibogluconate trisodium nonahydrate,葡萄糖酸锑钠	Phosphatase	Metabolism
	Sodium stibogluconate (Stibogluconate trisodium nonahydrate) 是一种有效的蛋白酪氨酸磷酸酶 (phosphatase) 抑制剂。它在10，100 和 100 μg/mL 时分别抑制 99% 的 SHP-1，SHP-2 和 PTP1B 活性。
T16724	Razuprotafib AKB-9778	Phosphatase; Others	Metabolism; Others
	Razuprotafib (AKB-9778) 是一种 VE-PTP (HPTPß)催化活性的有效选择性抑制剂，抑制结构相关磷酸酶 PTP1B。除 HPTPη 和 HPTPγ 外，它对 VE-PTP 具有良好的选择性。它能够促进 TIE2 活化，增强 ANG1 诱导的 TIE2 活化，并刺激 TIE2 通路中信号分子的磷酸化。
T15166	DPM-1001	Phosphatase	Metabolism
	DPM-1001 is an orally bioavailable and non-competitive protein-tyrosine phosphatase (PTP1B) inhibitor (IC50: 100 nM) with the anti-diabetic property.
T15243	Ertiprotafib PTP 112	Phosphatase; PPAR	DNA Damage/DNA Repair; Metabolism
	Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPARα/PPARβ).
T11730	JTT 551	Others	Others
	JTT 551 can be used in the research of type 2 diabetes mellitus. JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively.
T25953	PHPS1 Sodium PHPS1 Na,PHPS1 Sodium salt
	PHPS1 sodium 是 Shp2的选择性抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的Ki 值分别为 0.73，5.8，10.7，5.8 和 0.47 μM。
T69633	TCS-401
	TCS-401 is an insulin receptor sensitizing agent; Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B).
T72216	DPM-1001 trihydrochloride
	DPM-1001 trihydrochloride 是一种有效的，特异性的，具有口服活性的，且非竞争性的蛋白酪氨酸磷酸酶 (PTP1B) 抑制剂，其 IC50为 100 nM。DPM-1001 trihydrochloride 是特异性 PTP1B 抑制剂 MSI-1436 (IC50=600 nM) 的类似物。DPM-1001 trihydrochloride 具有抗糖尿病特性。
T79844	Anticancer agent 143	Phosphatase	Metabolism
	Anticanceragent 143（化合物 369），作为PTPN2/PTP1B双重抑制剂，表现出强效活性，其IC50值均低于2.5 nM。该化合物主要用于癌症研究领域。
T76019	[pTyr5] EGFR (988-993) (TFA)
	[pTyr5]EGFR(988-993) TFA 来源于表皮生长因子受体 (EGFR 988-993) 的自磷酸化位点 (Tyr992)。[pTyr5] EGFR(988-993) TFA 常与催化活性低的蛋白-酪氨酸磷酸1B (PTP1B) 结合。
T35877	MurA-IN-1
	MurA-IN-1 (compound 1a) is a PTPRR inhibitor, with IC50 values of 0.23 μM, 0.8 μM, 0.75 μM and 0.09 μM for PTP1B, PTPN5, PTPN7 and PTPRR, respectively[1]. (A family of human MAPK-specific protein tyrosine phosphatases) [1]. Jeyanthy Eswaran, et al. Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. Biochem J. 2006 May 1;395(3):483-91.
T39167	GS-493
	GS-493, a highly specific protein tyrosine phosphatase SHP2 (PTPN11) inhibitor, exhibits remarkable potency with an IC50 of 71 nM. It displays 29- and 45-fold greater affinity towards SHP2 compared to its related counterparts, SHP1 and PTP1B, respectively. In addition, GS-493 impedes both cellular motility and growth of cancer cells, portraying promising antitumor effects.
TP1613	[pTyr5] EGFR (988-993) [pTyr5] EGFR 988-993
	[pTyr5] EGFR (988-993) is a compound obtained from the auto-phosphorylation site, Tyr992, located within the sequence of the epidermal growth factor receptor (EGFR 988-993). This compound is frequently found bound with the catalytically inactive protein-tyrosine phosphate 1B (PTP1B).
T41018	CPT-157633
	CPT-157633 is a difluoro-phosphonomethyl phenylalanine derivative that acts as a potent inhibitor of the enzyme PTP1B. It effectively prevents the development of glucose intolerance induced by binge drinking.
T79845	Anticancer agent 144	Phosphatase	Metabolism
	Anticanceragent 144（化合物444）作为一种有效的PTPN2/PTP1B双重抑制剂，展现出卓越的抑制活性，其IC50值均低于2.5 nM。该化合物主要用于癌症研究领域。
T79479	MptpB-IN-2	Antibiotic	Microbiology/Virology
	MptpB-IN-2（化合物20）是一种高选择性的结核分枝杆菌蛋白酪氨酸磷酸酶B（MptpB）抑制剂，其对MptpB、MptpA和PTP1B的IC50值分别为0.64 μM、4.06 μM和4.14 μM。此化合物对Mtb H37Rv表现出较低的抗结核活性，MIC为64.9 μM。
T71811	Lobaric acid
	Lobaric acid is a depsidone metabolite that has been isolated from Stereocaulon lichen species with antioxidant, antiproliferative, antiviral, and enzyme inhibitory activites. It scavenges superoxide radicals in a cell-free assay (IC50 = 97.9 μmol) and inhibits proliferation in a panel of leukemia, colorectal, gastric, breast, ovarian, prostate, pancreatic, and lung cancer cell lines (EC50s = 15.2-63.9 μg/ml). Lobaric acid inhibits protein tyrosine phosphatase 1B (PTP1B; IC50 = 0.87 μM for the h...
T39677	MY33-3 MY33-3
	MY33-3 is a powerful and specific inhibitor of receptor protein tyrosine phosphatase (RPTP)β/ζ, demonstrating an IC50 value of approximately 0.1 μM. Moreover, MY33-3 exhibits inhibitory activity against PTP-1B with an IC50 value of about 0.7 μM. Additionally, MY33-3 has been shown to effectively decrease ethanol consumption and alleviate neuroinflammation and cognitive dysfunction induced by Sevoflurane.
T10594	bpV(phen)	PTEN	PI3K/Akt/mTOR signaling
	bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).

化合物

Cat.No: T7356

Synonym: PTP1B inhibitor,5-苯基-1,2,5-噻二唑烷-3-酮 1,1-二氧化物

Target: Phosphatase

Cat.No: T12577

Target: Phosphatase

Cat.No: T67893

Target: Phosphatase

Cat.No: T4256

Target: Phosphatase

Cat.No: T24073

Synonym: NUN 17724,PTP1B-inhibitor-2,PTP1B IN 2,PTP1B-IN-2,PTP1B-inhibitor-4,FRJ,PTP1B inhibitor 4,NUN17724,PTP1B inhibitor 2,PTP1BIN2,NUN-17724

Target: Phosphatase

Cat.No: T12578

Synonym: PTP1B-IN-8

Target: Phosphatase

Cat.No: T12579

Synonym: PTP1B-IN-9

Target: Proteasome

Cat.No: T40745

Synonym: PTP1B-IN-13

Cat.No: T40835

Synonym: PTP1B-IN-14

Cat.No: T63739

PTP1B-IN-3 diammonium

Cat.No: T61851

PTP1B/AKR1B1-IN-2

Cat.No: T78703

Target: Phosphatase

Cat.No: T63022

Cat.No: T63435

Cat.No: T63021

PTP1B/AKR1B1-IN-1

Cat.No: T78702

Target: Phosphatase

Cat.No: T63023

Cat.No: T4340

Target: Phosphatase

Cat.No: T23133

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Cat.No: T28410

Synonym: PHPS-1,PHPS 1

Target: Phosphatase

Cat.No: T9921

Target: TNF

Cat.No: T7704

Target: Phosphatase

Pentamidine isethionate

Cat.No: T1654

Synonym: Pentamidine isethionate salt,Pentamidine diisethionate,喷他脒羟乙磺酸盐

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Pentamidine dihydrochloride

Cat.No: T23132

Synonym: 喷他脒二盐酸盐,MP-601205 dihydrochloride

Target: Phosphatase, Antibacterial, Antibiotic, Parasite, Antifungal

Bis(maltolato)oxovanadium(IV)

Cat.No: T22276

Synonym: 双(麦芽醇)氧钒(IV),BMOV,Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium,Bis(maltolato)oxovanadium (IV)

Target: Phosphatase, Others

Cat.No: T7381

Target: Phosphatase

2-Bromo-4'-hydroxyacetophenone

Cat.No: T7084

Synonym: SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮

Target: Phosphatase

Cat.No: T9938

Synonym: EX-A4742

Target: Others

Cat.No: T4627

Target: Others

PTP Inhibitor IV

Cat.No: T22137

Target: Others

Sodium stibogluconate

Cat.No: T13013

Synonym: Stibogluconate trisodium nonahydrate,葡萄糖酸锑钠

Target: Phosphatase

Cat.No: T16724

Synonym: AKB-9778

Target: Phosphatase, Others

Cat.No: T15166

Target: Phosphatase

Cat.No: T15243

Synonym: PTP 112

Target: Phosphatase, PPAR

Cat.No: T11730

Target: Others

Cat.No: T25953

Synonym: PHPS1 Na,PHPS1 Sodium salt

Cat.No: T69633

DPM-1001 trihydrochloride

Cat.No: T72216

Anticancer agent 143

Cat.No: T79844

Target: Phosphatase

[pTyr5] EGFR (988-993) (TFA)

Cat.No: T76019

Cat.No: T35877

Cat.No: T39167

[pTyr5] EGFR (988-993)

Cat.No: TP1613

Synonym: [pTyr5] EGFR 988-993

Cat.No: T41018

Anticancer agent 144

Cat.No: T79845

Target: Phosphatase

Cat.No: T79479

Target: Antibiotic

Cat.No: T71811

Cat.No: T39677

Synonym: MY33-3

Cat.No: T10594

Target: PTEN

Cat. No.	Product Name	Target	Signaling Pathways
T73073	PTP1B-IN-21
	PTP1B-IN-21 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.56 μM)，抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP；IC50>100 μM)，PTP1B 是抑制 2 型糖尿病的重要靶点。
T73072	PTP1B-IN-20
	PTP1B-IN-20 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.05 μM)，抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP；IC50=78.0 μM)，PTP1B 是抑制 2 型糖尿病的重要靶点。
TCS1372	Atraric acid	Phosphatase; Androgen Receptor	Endocrinology/Hormones; Metabolism
	Atraric acid 衍生物作为一种新的化学先导结构，用于作为 AR 拮抗剂的新型治疗化合物，可用于预防或治疗前列腺疾病。它以剂量依赖性方式抑制 PTP1B 活性，IC50 值为 51.5 uM，表明阿特拉酸具有治疗糖尿病的潜力。
T5708	LUPENONE	Phosphatase; Parasite	Metabolism; Microbiology/Virology
	Lupenone 是从Rhizoma Musae 中分离出的 lupine 型三萜类天然产物。它有如抗炎，抗病毒，抗糖尿病，抗癌，改善南美锥虫病的药理活性。
TN1990	Norathyriol 芒果苷元	Akt; DNA/RNA Synthesis; AMPK; PPAR	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling
	Norathyriol 是来自芒果的芒果苷代谢物，具有抗氧化、抗癌、抗菌和抗炎活性。它以非竞争性方式抑制 α-葡萄糖苷酶，IC50为 3.12 μM。它还抑制PPARα、PPARβ和PPARγ，IC50分别为 92.8、102.4 和 153.5 µM。
TN1470	Cassiaside B2 决明子苷B2	Phosphatase; MAO; 5-HT Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Cassiaside B2 是蛋白酪氨酸磷酸酶1B (PTP1B) 和人单胺氧化酶A (hMAO-A) 的抑制剂。Cassiaside B2是 5-HT2C 受体的激动剂，具有抗过敏活性。Cassiaside B2 是萘吡喃酮参比提取物（NRE）的有效成分之一。
TN1956	Mulberrofuran G	Phosphatase; HBV; Glucosidase	Metabolism; Microbiology/Virology
	Mulberrofuran G分离自自 Morus alba L.，具有抗乙型肝炎病毒活性，可保护缺血损伤诱导的细胞死亡。Mulberrofuran G 是一种 PTP1B 和 α-葡萄糖苷酶的双重抑制剂，可用于研究阿尔茨海默症。
TN1691	Glabrol 光甘草酚,光甘草醇	P450; NF-κB; NO Synthase; Acyltransferase	Immunology/Inflammation; Metabolism; NF-κB
	Glabrol 是分离自甘草根的乙醇提取物中的一种异戊二烯类黄酮，是一种有效且非竞争性的酰基辅酶 A：胆固醇酰基转移酶（ACAT）抑制剂，抑制大鼠肝脏微粒体 ACAT 的 IC50为 24.6 μM。
TN2111	Prunin Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷	Phosphatase; Anti-infection; Virus Protease	Metabolism; Microbiology/Virology
	Prunin (Naringenin 7-0-glucoside) 是一种人肠道病毒 A71 抑制剂。它抑制蛋白酪氨酸磷酸酶 1B，IC50值为 5.5 μM。
T3851	Vicenin 2 Vicenin -2,维采宁 2,新西兰牡荆苷	RAAS	Endocrinology/Hormones
	Vicenin 2 来源于广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂，IC50=43.83 μM。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
TN1859	Licoflavone A	Phosphatase	Metabolism
	Licoflavone A 是分离自甘草根的黄酮类化合物，可以抑制酪氨酸磷酸酶 1B 的活性，IC50为 54.5 μM。
T13740	Isotanshinone IIA	Others	Others
	Isotanshinone IIA, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. is an abietane-type diterpene metabolite.
TN1053	Aloe-emodin-8-O-β-D-glucopyranoside Aloe-emodin-8-O-beta-D-glucopyranoside,芦荟大黄素-8-O-β-D-葡萄糖苷	Phosphatase	Metabolism
	Aloe-emodin-8-O-β-D-glucopyranoside (Aloe-emodin-8-O-beta-D-glucopyranoside) 是一种分离自Saussrurea lappa 中的化合物，是一种温和的人类蛋白酪氨酸磷酸酶 1B 抑制剂，其IC50=26.6 μM。
T7028	Licochalcone C LICOCHALCONEC,甘草查尔酮C	Phosphatase; Antioxidant; Glucosidase	Metabolism; oxidation-reduction
	Licochalcone C (LICOCHALCONEC) 能够抑制 α-葡萄糖苷酶，其对 α-葡萄糖苷酶的 IC50 <100 nM，对蛋白酪氨酸磷酸酶 1B 的 IC50=92.43 μM 。
TN5400	Aerugidiol
	Aerugidiol inhibits protein tyrosine phosphatase 1B (PTP1B).
TN2913	3-Acetoxy-11-ursen-28,13-olide	Phosphatase	Metabolism
	3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibits weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line.
TN3335	Abyssinone V	Phosphatase	Metabolism
	Abyssinone V 是一种从刺桐茎皮中分离的天然化合物，是蛋白质酪氨酸磷酸酶 1B (PTP1B) 的抑制剂。
TN3505	Beta-Peltoboykinolic acid	Phosphatase	Metabolism
	Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cytotoxic activity.
T38587	Chrysophanol triglucoside
	Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia , inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC 50 s of 80.17 and 197.06 μM, respectively. Chrysophanol triglucoside has the potential for diabetes research.
TN1775	Isocryptotanshinone	ERK; JNK; STAT	JAK/STAT signaling; MAPK; Stem Cells
	Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes.
TN4839	Psidial A	Others	Others
	Psidial A shows activity to enzyme PTP1B; it also reduces tumor growth and stimulate uterus proliferation.
TN1832	Kanzonol C	Others; NF-κB; Tyrosinase	NF-κB; Others; Proteases/Proteasome
	Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it shows the inhibition of matrix metalloproteinase (MMP)-2 secretion from brain tumor-derived glioblastoma cells.
TN2288	Uralenol 乌拉尔醇	Others; Estrogen/progestogen Receptor; Tyrosinase	Endocrinology/Hormones; Others; Proteases/Proteasome
	Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as substrate( IC50 =49.5 μM). Uralenol shows potent anti-proliferation effects on ER-positive breast cancer MCF-7 cells in vitro.
T75495	Rubrofusarin 6-O-β-D-glucopyranoside
	Rubrofusarin 6-O-β-D-glucopyranoside为Rubrofusarin的糖苷形式，具有抑制蛋白酪氨酸磷酸酶 1B (PTP1B) 的活性，IC50值为87.36 μM，适用于糖尿病和抑郁症研究。
TN4551	Methyl orsellinate	Phosphatase; cAMP; Antifection	GPCR/G Protein; Metabolism; Microbiology/Virology
	Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interact with bovine-brain calmodulin and inhibit the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase. Methyl orsellinate can inhibit PTP1B activity with 50% inhibitory concentration values of 277 +/- 8.6 microM, the selective inhibition of PTP1B has been widely recognized as a potential ...
TN3525	Boehmenan	ERK; Phosphatase; EGFR; PARP; MEK; Wnt/beta-catenin; Akt; Caspase; STAT; p53	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell
T80008	Stevisaliosides D	Phosphatase	Metabolism
	Stevisaliosides D (Compound 5) 是从甜叶菊根中提取的化合物，具有抑制PTP1B的活性（IC50：31.8 μM），应用于抗糖尿病研究。
T79985	Cryptosporioptide A	Phosphatase	Metabolism
	Cryptosporioptide A (Compound 3)是一种从昆虫寄生真菌Cordyceps gracilioides中分离出的色素蛋白酪氨酸磷酸酶抑制剂，针对PTP1B、SHP2、CDC25B、LAR和SHP1等酶展示了抑制作用，其IC50值分别为7.3、5.7、7.6、>50、4.9 μg/mL。
T75603	cis-Ferulic acid 4-O-β-D-glucopyranoside
	cis-Ferulic acid 4-O-β-D-glucopyranoside (compound 7)是一种从西伯利亚白刺分离的酚糖苷，不仅具有抗氧化活性，还能强效抑制磷酸酶PTP1B。
TN2887	3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid	Phosphatase	Metabolism
	(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM.
TN4279	Isoderrone	Tyrosinase	Proteases/Proteasome
	Isoderrone 在体外对α-葡萄糖苷酶(α-glucosidase)有抑制作用；它是一种蛋白酪氨酸磷酸酶1B（PTP1B）抑制剂，IC50值为22.7±1.7μM，表明它可能是一种治疗2型糖尿病的新药。
T3930	Taraxerol acetate 醋酸蒲公英霜,Taraxeryl acetate	Phosphatase; HSV	Metabolism; Microbiology/Virology
	Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS cells than taraxerol. A. roxburghiana has antidiabetic activity, could be attributed due to PTP
T80007	Stevisalioside A	Phosphatase	Metabolism
	Stevisalioside A (Compound 2)，一种从甜叶菊根提取的化合物，展现出抗糖尿病的口服活性。该化合物有效抑制PTP1B，IC50为526.8 μM，并能降低Stevisalioside A引起的高血糖小鼠血糖水平，改善餐后血糖峰值及口服葡萄糖和胰岛素耐量测试结果。
TN4064	Flavoglaucin	Phosphatase; IL Receptor; TNF; NOS; NF-κB; COX; Nrf2; Prostaglandin Receptor; Autophagy	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB
	Flavoglaucin exhibits significant inhibitory effects on PTP1B, the IC50 value of 13.4, micrometer; it also shows good binding affinity for human opioid or cannabinoid receptors. Flavoglaucin appears to be an antitumor promoter, it also has anti-inflammato
TN2928	Pygenic acid A 3-Epicorosolic acid,脓毒酸A
	3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.3-Epicorosolic acid shows both potent α-glucosidase and pro
T38069	Aquastatin A
	Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K....
T3827	Rhein-8-glucoside calcium 大黄酸-8-O-β-D-葡萄糖苷,Rhein-8-O-β-D-glucopyranoside,Rhein-8-glucoside calcium salt	Phosphatase; Antibacterial	Metabolism; Microbiology/Virology
	Rhein-8-glucoside calcium (Rhein-8-glucoside calcium salt) salt 是一种从 Saussurea lappa 根的 EtOH 提取物中，分离得到的蒽醌类 hPTP1B 抑制剂，IC50值为11.5 μM，具有抗菌作用。

天然产物

Cat.No: T73073

Cat.No: T73072

Cat.No: TCS1372

Target: Phosphatase, Androgen Receptor

Cat.No: T5708

Target: Phosphatase, Parasite

Cat.No: TN1990

Synonym: 芒果苷元

Target: Akt, DNA/RNA Synthesis, AMPK, PPAR

Cat.No: TN1470

Synonym: 决明子苷B2

Target: Phosphatase, MAO, 5-HT Receptor

Mulberrofuran G

Cat.No: TN1956

Target: Phosphatase, HBV, Glucosidase

Cat.No: TN1691

Synonym: 光甘草酚,光甘草醇

Target: P450, NF-κB, NO Synthase, Acyltransferase

Cat.No: TN2111

Synonym: Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷

Target: Phosphatase, Anti-infection, Virus Protease

Cat.No: T3851

Synonym: Vicenin -2,维采宁 2,新西兰牡荆苷

Target: RAAS

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Cat.No: TN1859

Target: Phosphatase

Isotanshinone IIA

Cat.No: T13740

Target: Others

Aloe-emodin-8-O-β-D-glucopyranoside

Cat.No: TN1053

Synonym: Aloe-emodin-8-O-beta-D-glucopyranoside,芦荟大黄素-8-O-β-D-葡萄糖苷

Target: Phosphatase

Cat.No: T7028

Synonym: LICOCHALCONEC,甘草查尔酮C

Target: Phosphatase, Antioxidant, Glucosidase

Cat.No: TN5400

3-Acetoxy-11-ursen-28,13-olide

Cat.No: TN2913

Target: Phosphatase

Cat.No: TN3335

Target: Phosphatase

Beta-Peltoboykinolic acid

Cat.No: TN3505

Target: Phosphatase

Chrysophanol triglucoside

Cat.No: T38587

Isocryptotanshinone

Cat.No: TN1775

Target: ERK, JNK, STAT

Cat.No: TN4839

Target: Others

Cat.No: TN1832

Target: Others, NF-κB, Tyrosinase

Cat.No: TN2288

Synonym: 乌拉尔醇

Target: Others, Estrogen/progestogen Receptor, Tyrosinase

Rubrofusarin 6-O-β-D-glucopyranoside

Cat.No: T75495

Methyl orsellinate

Cat.No: TN4551

Target: Phosphatase, cAMP, Antifection

Cat.No: TN3525

Target: ERK, Phosphatase, EGFR, PARP, MEK, Wnt/beta-catenin, Akt, Caspase, STAT, p53

Stevisaliosides D

Cat.No: T80008

Target: Phosphatase

Cryptosporioptide A

Cat.No: T79985

Target: Phosphatase

cis-Ferulic acid 4-O-β-D-glucopyranoside

Cat.No: T75603

3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid

Cat.No: TN2887

Target: Phosphatase

Cat.No: TN4279

Target: Tyrosinase

Taraxerol acetate

Cat.No: T3930

Synonym: 醋酸蒲公英霜,Taraxeryl acetate

Target: Phosphatase, HSV

Stevisalioside A

Cat.No: T80007

Target: Phosphatase

Cat.No: TN4064

Target: Phosphatase, IL Receptor, TNF, NOS, NF-κB, COX, Nrf2, Prostaglandin Receptor, Autophagy

Cat.No: TN2928

Synonym: 3-Epicorosolic acid,脓毒酸A

Cat.No: T38069

Rhein-8-glucoside calcium

Cat.No: T3827

Synonym: 大黄酸-8-O-β-D-葡萄糖苷,Rhein-8-O-β-D-glucopyranoside,Rhein-8-glucoside calcium salt

Target: Phosphatase, Antibacterial

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