143
51
1
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88
Cat. No. | Product Name | ||
---|---|---|---|
L3300 | 组胺&褪黑色素化合物库 | 153 compounds | |
153 种生物活性小分子化合物,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0007 |
SYBR Green qPCR Master Mix (High ROX)
SYBR Green qPCR Master Mix (High ROX) |
Solution in bottle | |
C0006 |
SYBR Green qPCR Master Mix (No ROX)
SYBR Green qPCR Master Mix (No ROX) |
Solution in bottle | |
C0008 |
SYBR Green qPCR Master Mix (Low ROX)
SYBR Green qPCR Master Mix (Low ROX) |
Solution in bottle |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1497L |
Mast Cell Degranulating Peptide HR-2 acetate
Mast Cell Degranulating Peptide HR-2 acetate(80388-04-1 free base) |
Others | Others |
Mast Cell Degranulating Peptide HR-2 acetate(80388-04-1 free base) 来自大黄蜂 Vespa orientalis 的肥大细胞脱粒肽,其生物学效应类似于来自蜂毒的肥大细胞脱粒肽。 | |||
TP1568 |
Mast cell degranulating peptide (28-49)
|
||
Mast cell degranulating peptide (28-49) is a bee venom depolarizer that can improve the cGMP content of cerebellum tablets in mice. | |||
TP1497 |
Mast Cell Degranulating Peptide HR-2
|
||
Peptide from giant hornet Vespa orientalis that has biological effects similar to mast cell degranulating peptide from bee venom. | |||
T9689 |
M4205
|
c-Kit | Tyrosine Kinase/Adaptors |
M4205 是一种 c-Kit 抑制剂,对外显子 11、13、17 中的 c-Kit 突变具有高活性。 | |||
T0118 |
Mizolastine
SL 850324,咪唑司汀,咪唑斯汀 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Mizolastine (SL 850324) 是组胺 H1 受体拮抗剂,IC50为 47 nM。它用于治疗过敏反应,如花粉热和荨麻疹等。 | |||
T6488 |
Epinastine hydrochloride
Alesion,Epinastine HCl,WAL-801CL HCl,依匹斯汀盐酸盐,Elestat |
5-HT Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Epinastine hydrochloride (WAL-801CL HCl) 是抗组胺剂和肥大细胞稳定剂,是一种可口服的选择性组胺 H1 受体拮抗剂,可抑制 IL-8 释放,具有抗过敏作用。 | |||
T2648 |
Pimecrolimus
SDZ-ASM 981,ASM 981,吡美莫司 |
Others | Others |
Pimecrolimus (SDZ-ASM 981) 是一种免疫亲和素配体,能与胞质受体特异性的结合。 | |||
T0994 |
Ketotifen fumarate
HC 20511 fumarate,富马酸酮替芬 |
PDE; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Ketotifen fumarate (HC 20511 fumarate) 是组胺 H1 受体和炎症介质释放的环七噻吩阻滞剂。 | |||
T15259 |
Evatanepag
CP-533536 free acid,2-[3-[N-(4-叔丁基苄基)-N-(吡啶-3-基磺酰基)氨基甲基]苯氧基]乙酸 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
Evatanepag (CP-533536 free acid) 是一种 EP2 受体选择性前列腺素 E2 (PGE2) 激动剂,可诱导局部骨形成,EC50 为 0.3 nM。它在大鼠骨折愈合模型中以单剂量局部给药时表现出愈合骨折的能力。 | |||
T3148 |
MK-571 sodium
L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid |
Leukotriene Receptor; LTR | GPCR/G Protein; Immunology/Inflammation |
MK-571 sodium (L-660711 sodium salt) 是一种可口服的选择性白三烯 D4受体拮抗剂,在豚鼠和人肺膜的 Ki 分别为0.22 和 2.1 nM。 | |||
T22256 |
c-Kit-IN-5-1
3-(2-Aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one,AMG-25,3-(2-aminoquinazolin-6-yl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]pyridin-2-one |
c-Kit | Tyrosine Kinase/Adaptors |
c-Kit-IN-5-1 (AMG-25) 是一种新型的、高效的、选择性的 c-Kit 抑制剂。 | |||
T19966 |
Clemastine
HS-592,Mecloprodin,Meclastin,HS592,HS 592 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Clemastine (Meclastin) 是 H1 受体的拮抗剂,具有抗炎作用。 | |||
T6885 |
Marimastat
BB2516,马立马司他,KB-R8898,TA2516 |
MMP | Proteases/Proteasome |
Marimastat (BB2516) 是一种血管生成和转移抑制剂,限制血管的生长和生成。它是一种广谱的,具有口服活性的MMPs 抑制剂,有效抑制 MMP-9 , MMP-1, MMP-2, MMP-14, MMP-7,用于癌症的研究。 | |||
T2743 |
Ilomastat
Galardin,GM6001,伊洛马司他 |
MMP | Proteases/Proteasome |
Ilomastat (GM6001) 是广谱的基质金属蛋白酶 (MMP) 抑制剂,可抑制 MMP 的活性,IC50值分别为 1.5 nM (MMP-1),1.1 nM (MMP-2),1.9 nM (MMP-3),0.5 nM (MMP-9),对人皮肤成纤维细胞胶原酶 (MMP-1) 的Ki=为 0.4 nM。 | |||
T6011 |
Batimastat
巴马司他,BB94 |
MMP | Proteases/Proteasome |
Batimastat (BB94) 是广谱MMP 抑制剂,能够抑制MMP-1 (IC50:3 nM),MMP-2 (IC50:4 nM),MMP-9 (IC50:4 nM),MMP-7 (IC50:6 nM) 和 MMP-3 (IC50:20 nM)。 | |||
T67959 |
Pirodomast
|
Thrombin; Serine Protease | Proteases/Proteasome |
Pirodomast 是血栓素 A(TXA2)合成酶抑制剂。Pirodomast 能抑制白三烯(LT)D4、C4、E4 的形成和血栓素 B2(TXB2)的活性,但对组胺、甲氧胆碱、血清素、LTC4 或血小板活化因子诱导的豚鼠支气管痉挛的拮抗作用较弱或无效。Pirodomast 在体外对豚鼠气管只有微弱的松弛活性。Pirodomast 是一种潜在的抗过敏化合物,在体外可抑制胰蛋白酶的蛋白水解活性,在体内可阻止抗原诱发过敏绵羊的即时和晚期哮喘反应,抑制抗原诱导的过敏绵羊对组胺和卡巴胆碱的气道高反应性。 | |||
T83168 |
Aderamastat
FP-003,FP-025 |
MMP | Proteases/Proteasome |
Aderamastat (FP-025) 是一种具有口服活性的基质金属蛋白酶12(MMP-12)抑制剂,适用于过敏性哮喘、COPD与肺纤维化的研究。 | |||
T30190 |
Ataquimast
|
Others | Others |
Ataquimast 用于治疗晚期受体阳性乳腺癌。 | |||
T35859 |
Aldumastat
GLPG1972,S201086,G504572 |
Others | Others |
Aldumastat(GLPG1972)是一种具有高效性、特异性和口服活性的 ADAMTS-5抑制剂。Aldumastat 可用于研究膝骨关节炎。 | |||
T68128 |
Picumast
|
||
Picumast 是一种具有抗过敏活性,可被用于治疗哮喘,可能用于治疗治疗过敏性气道疾病。 | |||
TP1386L1 |
Mastoparan acetate(72093-21-1 free base)
|
Others | Others |
Mastoparan acetate(72093-21-1 free base) 是一种来自黄蜂毒液的肽毒素。它的化学结构为 Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2。 | |||
T0147 |
Clemastine fumarate
HS-592 (fumarate),富马酸氯马斯汀,Meclastine fumarate,Meclastine (fumarate) |
Autophagy; Histamine Receptor | Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Clemastine fumarate (Meclastine (fumarate)) 是一种合成乙醇胺,具有抗胆碱能、镇静和组胺 H1 拮抗作用。 | |||
T5449 |
Bamaquimast
L 0042,F 10126 |
Proton pump | Membrane transporter/Ion channel |
Bamaquimast (L 0042) 是一种 proton pump 抑制剂,可用于研究哮喘类的免疫系统疾病和呼吸系统疾病。 | |||
T12539L |
Prinomastat
KB-R9896,普啉司他,AG3340 |
MMP | Proteases/Proteasome |
Prinomastat inhibits MMP-2, MMP-3 and MMP-9 (Kis: 0.05 nM, 0.3 nM and 0.26 nM, respectively). Prinomastat crosses the blood-brain barrier. It also has antitumor activity. Prinomastat is a broad-spectrum, potent, orally active metalloproteinase inhibitor ( | |||
T10461 |
Batimastat sodium salt
BB-94 sodium salt |
MMP | Proteases/Proteasome |
Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3). | |||
T80322 |
Mastoparan B
|
||
Mastoparan B,源自黄蜂Vespa的抗菌肽,可引起红细胞形态由常规盘形转变为锯齿状。 | |||
T19665 |
Amastatin hydrochloride
氨肽酶抑制剂盐酸盐,BIMI-1803,Amastatin HCl,ZX-AFC000547,ZXAFC000547,BIMI1803,J-000280,J000280 |
||
Amastatin HCl is an inhibitor of aminopeptidase. It also induces vasoconstriction. | |||
T125590 |
Clemastanin A
|
||
Clemastanin A 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125590。 | |||
T76094 |
Mastoparan X
|
||
Mastoparan X 是一种GTP 结合调节蛋白 (G 蛋白) 激活肽,是一种来自黄蜂毒液的十四肽。Mastoparan X 通过直接激活与磷脂酶 C 偶联的G 蛋白来引起各种细胞的分泌。 | |||
T24817 |
Otaplimastat
J3.046.690J,SP8203,SP-8203,SP 8203 |
||
SP-8203 is a reactive oxygen species inhibitor and superoxide dismutase stimulant. | |||
T125511 |
Stigmast-7-en-3-ol
|
||
Stigmast-7-en-3-ol 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T125511。 | |||
T124943 |
6-Hydroxystigmasta-4,22-dien-3-one
|
||
6-Hydroxystigmasta-4,22-dien-3-one 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124943。 | |||
T62090 |
(Rac)-Tanomastat
|
||
Rac)-Tanomastat ((Rac)-BAY 12-9566) 是 Tanomastat 的外消旋体。其中 Tanomastat (BAY 12-9566) 是一种口服具有活力的、含锌羧基的非肽联苯基质金属蛋白酶(MMPs)抑制剂,能够抑制 MMP-2 (Ki: 11 nM)、MMP-3 (Ki: 143 nM)、MMP-9 (Ki: 301 nM)、MMP-13 (Ki: 1470 nM)。在几种实验性肿瘤模型中,Tanomastat 表现出抗侵袭和抗转移作用。 | |||
T68012 |
rebimastat
|
||
Rebimastat 是基于巯基的第二代基质金属蛋白酶(MMP)抑制剂,具有潜在的抗肿瘤活性。利莫司他选择性抑制几种 MMPs (MMP 1、2、8、9和14),从而诱导细胞外基质降解,抑制血管生成、肿瘤生长、侵袭和转移。 | |||
T84308 |
(24R)-Stigmastane-3β,5α,6α-triol
|
||
TP1386 |
Mastoparan
|
||
Mastoparan is a peptide toxin from wasp venom. It has the chemical structure Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2. | |||
T69301 | Picumast dihydrochloride | ||
Picumast dihydrochloride is a prophylactically active anti-allergic compound which combines inhibition of mediator release and action. The activity profile of PDH differs clearly from that of known prophylactic anti-allergic drugs such as DSCG and ketotifen. | |||
T12539 |
Prinomastat hydrochloride
KB-R9896 hydrochloride,AG3340 hydrochloride |
MMP | Proteases/Proteasome |
Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with Antitumor avtivity. | |||
T33215 |
Masticadienediol
|
||
Masticadienediol is a tetracyclic triterpene. | |||
T124674 |
3β,5α-Dihydroxystigmastan-6-one
|
||
3β,5α-Dihydroxystigmastan-6-one 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124674。 | |||
T124266 |
6α-Hydroxystigmast-4-en-3-one
|
||
6α-Hydroxystigmast-4-en-3-one 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124266。 | |||
T10817 |
Cipemastat
Ro 32-3555 |
Others | Others |
Cipemastat is a competitive inhibitor of human collagenases 1, 2, and 3 (Kis: 3.0, 4.4, and 3.4 nM). | |||
T16986 |
Tanomastat
BAY 12-9566 |
MMP | Proteases/Proteasome |
Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively. | |||
T31794 |
FireMaster 695
1,2-Bis(pentabromophenoxy)ethane,Decabromo diphenyl ethyl,Ethylene bis(pentabromophenoxide),Decabromodiphenoxyethane |
||
FireMaster 695 is a biochemical. | |||
T30164 |
Asobamast
|
||
Asobamast is a biochemical. | |||
T81850 |
MASTL-IN-2
|
||
MASTL-IN-2为MASTL(microtubule-associated Ser/Thr kinase-like)抑制剂,能够抑制人上皮MIA PaCa癌细胞的增殖,其IC50值为2.8 nM。 | |||
T22255 | Amastatin | Others | Others |
Amastatin is a non-toxic inhibitor of aminopeptidase A and leucine aminopeptidase, and its Ki for aminopeptidase A is 1 µM . | |||
T71488 | Cremastranone | ||
Cremastranone is a natural antiangiogenic homoisoflavanone. Cremastranone inhibits the proliferation, migration, and tube formation ability of human retinal microvascular endothelial cells. | |||
T80047 |
Polistes mastoparan
|
||
Polistes mastoparan 作为一种抗菌肽,能够增强S. aureus (金黄色葡萄球菌) 的K+流失并削弱其活性,其EC50为5 μM。 | |||
T69716 |
Solimastat
|
||
Solimastat is a novel oral, broad-spectrum matrix metalloproteinase inhibitor (MMPI), being >10-fold more active than marimastat in inhibiting the processing of cell-bound TNF-alpha. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN6737 |
(25R)-Spirost-4-ene-3,12-dione
|
Others | Others |
(25R)-Spirost-4-ene-3,12-dione 是一种天然产物。 | |||
T16943 |
Stigmastanol
|
Endogenous Metabolite | Metabolism |
Stigmastanol 是分离自Hypericum riparium 的 6-氨基衍生物。Hypericum riparium 是属于杜仲科的药用植物。 | |||
T2967 |
Stigmasterol
Stigmasterin,beta-Stigmasterol,豆甾醇 |
MMP; Endogenous Metabolite | Metabolism; Proteases/Proteasome |
Stigmasterol (Stigmasterin) 是一种植物性甾醇,具有抑制胆固醇的特性,此外在风湿性疾病的研究中被评价为抗硬化因子。 | |||
TN5064 |
Stigmasta-4,22-dien-3-one
|
Others | Others |
Stigmasta-4,22-dien-3-one has antioxidant activity. | |||
T83259 |
6β-Hydroxystigmasta-4,22-dien-3-one
|
||
6β-Hydroxystigmasta-4,22-dien-3-one为一类固醇化合物,可从Hedychium coronarium中提取。 | |||
TN5069 |
(5α)-Stigmastane-3,6-dione
Stigmastane-3,6-dione,豆甾烷-3,6-二酮 |
||
Stigmastane-3,6-dione has anti-inflammatory activity. 5 alpha-Stigmastane-3,6-dione shows antifeedant activity against bell weevils. | |||
TN5067 |
Stigmastane-3,5,6-triol
|
Antifection | Microbiology/Virology |
Stigmastane-3,5,6-triol and derivatives could be used for preparing antiviral medicine. | |||
TN2908 |
3,7,16-Trihydroxystigmast-5-ene
|
Others | Others |
3,7,16-Trihydroxystigmast-5-ene 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN2908,CAS号为 289056-24-2。 | |||
TN5065 |
Stigmasta-4,25-dien-3-one
|
Others | Others |
Stigmasta-4,25-dien-3-one 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5065,CAS号为 848669-08-9。 | |||
T81085 |
Stigmasta-3,5-dien-7-one
|
||
Stigmasta-3,5-dien-7-one为源自Harrisonia abyssinica之甾体化合物。 | |||
TN5068 |
Stigmastane-3,6-diol
|
Others | Others |
Stigmastane-3 beta, 6 alpha-diol and stigmastane-3 beta, 6 beta-diol possess marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, the 50% inhibitory dose is 0.5--1.0 mg/ear. | |||
TN1327 | 7,22,25-Stigmastatrienol | Others | Others |
7,22,25-Stigmastatrienol is a natural product | |||
TN5066 | Stigmasta-5,8-dien-3-ol | Others | Others |
Stigmasta-5,8-dien-3-ol 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5066,CAS号为 570-72-9。 | |||
TN5294 |
Stigmasta-4,22-diene-3β,6β-diol
|
||
Stigmasta-4,22-diene-3β,6β-diol 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5294,CAS号为 167958-89-6。 | |||
T83543 |
(E)-Masticadienonic acid
|
||
(E)-Masticadienonic acid为三萜类化合物,可从Vallesia glabra中提取。 | |||
T81086 |
Stigmast-5-ene-3,7-dione
|
||
Stigmast-5-ene-3,7-dione(Compound 10)是一种从Penianthus longifolius的根、叶与细枝中分离得到的化学物质。 | |||
TN2238 |
Stigmasterol glucoside
豆甾醇葡萄糖苷 |
Others | Others |
Stigmasterol glucoside, a constituent of Adenanthera pavonina seed and leaf, may be a plant anticancer agent. | |||
T83339 |
3β-(Acetyloxy)stigmast-5-en-7-one
|
||
3β-(Acetyloxy)stigmast-5-en-7-one 表现出抗补体活性。 | |||
TN3172 |
6beta-Hydroxystigmast-4-en-3-one
|
Others | Others |
6beta-Hydroxystigmast-4-en-3-one 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3172,CAS号为 36450-02-9。 | |||
TN5062 | Stigmast-4-ene-3,6-dione | ||
Stigmast-4-ene-3,6-dione has anti-inflammatory and anti-allergic properties. | |||
TN5285 |
Stigmast-4-ene-3β,6β-diol
|
||
Stigmast-4-ene-3beta,6beta-diol possesses marked inhibitory activity against 12-O- -tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. | |||
TN5063 |
Stigmasta-4,22,25-trien-3-one
|
Others | Others |
Stigmasta-4,22,25-trien-3-one is a natural product from Callicarpa giraldiana. | |||
TN4505 | Masticadienolic acid | Others | Others |
Masticadienolic acid is a specific competitive inhibitor of secreted phospholipase A2, it not only protects the active site histidine from alkylation but also inhibits the action of secreted from pancreas, synovial fluid, and bee venom. Masticadienolic ac | |||
T75638 | Himastatin | ||
Himastatin 是一种具有抗肿瘤活性的抗生素,由S. hygroscopicus sp 菌株产生。Himastatin 是一种二聚环六肽,含有哌嗪酸和一个独特的芳香族中心。 | |||
TN3254 |
7alpha-Hydroxystigmasterol
|
Others | Others |
7alpha-Hydroxystigmasterol是一种天然产物,属于菊科苍耳属,其产品编号为 TN3254,CAS号为 64998-19-2。7alpha-Hydroxystigmasterol可用作对照参考。 | |||
TN6801 |
Stigmastadienone
|
||
Stigmastadienone is a natural product. | |||
TN1506 |
Clemastanin B
直铁线莲宁B,落叶松树脂醇苷B |
Influenza Virus | Microbiology/Virology |
Clemastanin B has antioxidant and anti-inflammatory activities, it exerts its anti-influenza activity by inhibiting the virus multiplication, prophylaxsis and blocking the virus attachment. | |||
T4946 |
(+)-Columbianetin acetate
二氢欧山芹醇醋酸酯,COLUMBIANETIN ACETATE |
Others | Others |
(+)-Columbianetin acetate (COLUMBIANETIN ACETATE) 是一种 Columbianetin 异构体。其中Columbianetin 是植物抗毒素,与芹菜贮藏过程中对病原体的抗性有关,表现出良好的抗炎及抗真菌活性。 | |||
T6943 |
Picropodophyllin
AXL1717,苦鬼臼脂素,Picropodophyllin (PPP),Picropodophyllotoxin,PPP,苦鬼臼毒素 |
Apoptosis; IGF-1R | Apoptosis; Tyrosine Kinase/Adaptors |
Picropodophyllin (Picropodophyllin (PPP)) 是一种选择性的胰岛素样生长因子-1受体抑制剂,IC50为1 nM。 | |||
T6926 |
Palmitoylethanolamide
Mackpeart DR 14V,帕米醇,N-palmitoylethanolamine,Loramine P 256,Impulsin,AM 3112,Palmidrol |
Influenza Virus; Endogenous Metabolite; PPAR | DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Palmitoylethanolamide (Impulsin) 是一种内源性脂肪酸酰胺。它有消炎药、降压药、神经保护剂和抗惊厥药的作用。在给药后,Palmitoylethanolamide 可抑制促炎介质从活化肥大细胞的释放。 | |||
TN1516 |
Cnidicin
蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮 |
NOS; NO Synthase | Immunology/Inflammation |
Cnidicin 是一种香豆素,对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。 | |||
T5S1286 |
(+)-Columbianetin
二氢山芹醇,(S)-Columbianetin,Columbianetin |
Antifungal | Microbiology/Virology |
(+)-Columbianetin ((S)-Columbianetin) 是 Columbianetin 的异构体。其中Columbianetin 是一种植物抗毒素,与芹菜贮藏过程中对病原体的抗性有关,具有良好的抗真菌和抗炎作用。 | |||
T4S0797 |
Berberine
小檗碱,Berberin,Umbellatine,黄连素 |
Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy | Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶,具有抗肿瘤特性。 | |||
T5S2343 |
Acetylshikonin
乙酰紫草素,Acetyl shikonin |
Others; P450; AChE | Metabolism; Neuroscience; Others |
Acetylshikonin 来源于紫草根,具有抗癌、抗炎作用。它是一种 AChE 抑制剂,具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂,对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。 | |||
T3S0027 |
Picropodophyllotoxin
AXL 1717,Picropodophyllin,苦鬼臼毒素 |
IGF-1R | Tyrosine Kinase/Adaptors |
Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱,存在于五月树(Podophyllum peltatum) 中,是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达,而不干扰其他生长因子受体的活性,例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) )。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶,在多种癌细胞的生长和存活中起关键作用。 | |||
TN2895 |
3,5-Dicaffeoyl-epi-quinic acid
金银花 |
IL Receptor; p38 MAPK; TNF; Caspase; JNK; Histamine Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome |
3,5-Dicaffeoyl-epi-quinic acid shows anti-inflammatory activity, it may improve mast cell-mediated inflammatory diseases. | |||
TN3864 |
Dihydroresveratrol 3-O-glucoside
|
Others | Others |
Dihydroresveratrol 3-O-glucoside 是一种天然产物,存在于Camellia sinensis var. assamica (J.W. Mast.) Kitam.叶子。 | |||
T83329 |
4,7-Didehydroneophysalin B
|
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4,7-Didehydroneophysalin B,一种源自Physalis alkekengi L. var. franchetii (Mast.) Makino的黄酮类化合物,展现出胆碱酯酶的抑制作用。 | |||
T80998 |
Thapsigargicin
Thapsigargicine |
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Thapsigargicin(Thapsigargicine)作为肥大细胞和白细胞的激活剂,能诱导大鼠腹膜肥大细胞及人嗜碱性粒细胞释放组胺,并提升完整人血小板中的细胞质游离钙水平。 | |||
TN3062 |
4'-O-Methylnyasol
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
4'-O-Methylnyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. | |||
TN5647 |
Confluentin
|
||
Confluentin has antimicrobial activity against the gram-positive bacteria.Confluentin significantly inhibits compound 48/80-induced histamine release from rat peritoneal mast cells. Confluentin also shows weak cytotoxicity against four human tumor cell li | |||
T25687 |
Leukotriene C4
白三烯C4,LTC4,Leukotriene C |
||
Leukotriene C4 is the conjugation product of Leukotriene A4 and glutathione. It is the major arachidonic acid metabolite in human mast cells, macrophages, and antigen-sensitized lung tissue. It stimulates mucus secretion in the lung and produces contracti | |||
TN4392 |
Koaburaside
|
IL Receptor; TNF; Influenza Virus | Apoptosis; Immunology/Inflammation; Microbiology/Virology |
Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histamine release from mast cells. | |||
TN5279 |
Zeorin
|
ATPase; Calcium Channel; Antifection; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP24-BSA, it shows potent inhibitory effect by 40% decrease of histamine release. | |||
TN6539 | Pd-C-II | ||
Pd-C-II has anti-inflammation activity, it can inhibit TNF-α production and iNOS protein expression and inhibit COX-2 protein expression in LPS-stimulated RAW 264.7 cells. Pd-C-II inhibits anaphylactic mediator release from purified mast cells induced by | |||
TN3325 |
9-O-Feruloyl-5,5'-dimethoxylariciresinol
|
IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cytotoxicity against a small panel of human tumor cell lines, with ED50 values of 9.86 to approxi | |||
TN6667 |
Spinacetin
|
||
Spinacetin has anti-inflammatory effects, it weakly inhibited nitric oxide production and reduced prostaglandin E2 levels to different extents. It shows the activities in preventing inflammatory processes, which might be at least partially attributed to t | |||
TN1009 |
Epimagnolin B
|
NF-κB; NO Synthase; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; NF-κB |
Epimagnolin B 是一种双环氧木质素,分离自木兰中。它能够抑制 LPS 激活的小胶质细胞中 NO 的产生。它具有抗过敏以及抗炎作用。 | |||
TN4683 |
Nyasol
|
ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt; Antifection | Cytoskeletal Signaling; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling |
Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antifungal activity, it is significantly | |||
T37272 |
9(S),12(S),13(S)-TriHOME
|
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9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME... | |||
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Cat. No. | Product Name | Species | Expression System |
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TMPJ-01470 |
SCF Protein, Human, Recombinant
Mast Cell Growth Factor,c-Kit ligand,KITLG,MGF,Stem... |
Human | E. coli |
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors. | |||
TMPJ-00166 |
SCF Protein, Mouse, Recombinant
SCF,Hematopoietic growth factor KL,MGF,Steel factor,Mast... |
Mouse | E. coli |
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ... | |||
TMPJ-00051 |
IL-3 Protein, Mouse, Recombinant (His)
Mast cell growth factor,Il3,Multipotential colony-s... |
Mouse | HEK293 Cells |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. In addition, IL-3 also affects the functional activity of mature mast cells, basophils, eosinophils and macrophages.Because of its multiple functions and targets, it was originally studied under different names, including mast cell growth factor P-cell stimulating factor, bu... | |||
TMPH-02581 |
Chymase 1 Protein, Mouse, Recombinant (His)
Mast cell protease 5,Mast cell protease I,... |
Mouse | E. coli |
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Chymase 1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.2 kDa and the accession number is P21844. | |||
TMPY-01057 |
SPG21 Protein, Human, Recombinant (GST)
ACP33,GL010,spastic paraplegia 21 (autosomal recessive, ... |
Human | Baculovirus Insect Cells |
SPG21 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 61 kDa and the accession number is Q9NZD8-1. | |||
TMPH-02499 |
Allergin-1 Protein, Mouse, Recombinant (His & Myc)
Mca32,Gm885,Allergy inhibitory receptor 1,Mast cell... |
Mouse | E. coli |
Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction. Allergin-1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.1 kDa and the accession number is Q3TB92. | |||
TMPY-02752 |
SPG21 Protein, Mouse, Recombinant (His & GST)
ACP33,C78576,BM-019,GL010,D9Wsu18e,MAST,spastic par... |
Mouse | Baculovirus Insect Cells |
SPG21 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 62.8kDa and the accession number is Q9CQC8-1. | |||
TMPY-04139 |
MCEMP1 Protein, Human, Recombinant (mFc)
C19orf59,mast cell-expressed membrane protein 1 |
Human | HEK293 Cells |
MCEMP1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 36 kDa and the accession number is A0A384NYE9. | |||
TMPY-02574 |
Chymase 1 Protein, Human, Recombinant (His)
MCT1,chymase 1, mast cell,chymase,CYH |
Human | Baculovirus Insect Cells |
The STR polymorphism in the CMA1 gene is associated with asthma and that this association is even stronger with atopic asthma. CMA1 and IL-4 in atopic asthma and for IL-4 in atopy in general. The local angiotensin II system (LAS) has numerous functions, including the regulation of growth and differentiation in the gastrointestinal tract. Angiotensin II (AngII) may be generated by angiotensin-I-converting enzyme (ACE) or mast cell chymase (CMA1) and plays an important role in inflammatory process... | |||
TMPH-00486 |
Chymase Protein, Canine, Recombinant (His & SUMO)
Chymase,Alpha-chymase,CMA1,Mast cell protease I |
Canine | E. coli |
Chymase Protein, Canine, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPY-04969 |
Allergin 1 Protein, Mouse, Recombinant (hFc)
Gm885,mast cell immunoglobulin-like receptor 1,Alle... |
Mouse | HEK293 Cells |
Allergin 1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.8 kDa and the accession number is Q3TB92-1. | |||
TMPH-01641 |
CPA3 Protein, Human, Recombinant (His)
MC-CPA,CPA3,Mast cell carboxypeptidase A,Carboxypep... |
Human | E. coli |
CPA3 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPY-05061 |
Allergin 1 Protein, Human, Recombinant (hFc)
MCA32,C17orf60,mast cell immunoglobulin-like recept... |
Human | HEK293 Cells |
Allergin 1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50.1 kDa and the accession number is Q7Z6M3-1. | |||
TMPY-04963 |
Allergin 1 Protein, Human, Recombinant (His)
C17orf60,MCA32,mast cell immunoglobulin-like recept... |
Human | HEK293 Cells |
Allergin 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 24.8 kDa and the accession number is Q7Z6M3-1. | |||
TMPJ-00897 |
TPSB2 Protein, Mouse, Recombinant (His)
Tryptase-2,Mast cell protease 6,Tryptase beta-2,Try... |
Mouse | HEK293 Cells |
Tryptase beta-2(Tpsb2), also known as Mast cell protease 6(mMCP-6), belongs to the peptidase S1 family and Tryptase subfamily. Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It plays a role in innate immunity. Tpsb2 can be detected primarily in skin during embryogenesis. Tpsb2 can not be detected at early embryonic stages but is abundantly expressed in later stages with a peak at E17.5-E18.5. Tryp... | |||
TMPY-01027 |
Mast Cell Protease-1/MCPT-1 Protein, Mouse, Recombinant (His)
carnitine palmitoyltransferase 1B (muscle),AV080368,Mcp-1 |
Mouse | HEK293 Cells |
Mast Cell Protease 1 (MMCP-1), also known as MCP-1, MCPT-1 and β-chymase, is a member of the Chymase family of chymotrypsin-like serine proteases. MCPT-1 is a 26 kDa β-chymase that is a component of mast cell granules. It is a 226 amino acid (aa) protein that has a conserved pattern of six cysteines and one potential glycosylation site. The granule-derived mouse mast cell proteases-1 and -2 (mMCP-1 and -2) colocalize in similar quantities in mucosal mast cells but micrograms of mMCP-1 compared w... | |||
TMPJ-00894 |
SCF Protein, Rat, Recombinant (His)
Hematopoietic growth factor KL,Steel factor,Stem cell factor... |
Rat | E. coli |
Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase... | |||
TMPJ-00895 |
SCF Protein, Rat, Recombinant (HEK293, His)
steel factor,Mast cell growth factor,SLF,MGFSHEP7,S... |
Rat | HEK293 Cells |
SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II... | |||
TMPJ-00402 |
CD117 Protein, Human, Recombinant (hFc)
KIT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncog... |
Human | HEK293 Cells |
C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing sti... | |||
TMPH-01685 |
MAST4 Protein, Human, Recombinant (His & Myc)
|
Human | E. coli |
MAST4 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPY-05690 |
Human mastadenovirus B (HAdV-B) encapsidation protein IVa2 Protein (His)
|
HAdV-B | Baculovirus Insect Cells |
Human mastadenovirus B (HAdV-B) encapsidation protein IVa2 Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 52.06 kDa and the accession number is YP_002213830.1. | |||
TMPY-05685 |
Human mastadenovirus E (HAdV-E) fiber Protein (His)
|
HAdV-E | Baculovirus Insect Cells |
Human mastadenovirus E (HAdV-E) fiber Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 46.56 kDa and the accession number is Q6H1A8. | |||
TMPJ-01204 |
TPSAB1 Protein, Human, Recombinant (His)
TPS1,tryptase alpha/beta 1,TPS2,tryptase α/β1,tryptase α/β 1... |
Human | HEK293 Cells |
Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1), also known as mast cell protease 7 (MCPT7), it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and s... | |||
TMPJ-01465 |
GM-CSF/CSF2 Protein, Human, Recombinant (E. coli)
Colony-Stimulating Factor,CSF2,CSF,Sargramostim,集落刺激因子,Molgr... |
Human | E. coli |
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryo... | |||
TMPJ-00042 |
TSLP Protein, Human, Recombinant
TSLP,Thymic stromal lymphopoietin |
Human | E. coli |
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region. Human TSLP has two isoforms lfTSLP and sfTSLP produced by alternative splicing . lfTSLP is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral... | |||
TMPJ-00187 |
CD300A Protein, Human, Recombinant (hFc & His)
CMRF35-like molecule 8,NK inhibitory receptor,CMRF-35-H9,Imm... |
Human | HEK293 Cells |
CD300A is a single-pass type I membrane protein which belongs to the CD300 family. It contains 1 Ig-like V-type (immunoglobulin-like) domain. The CD300 family of myeloid immunoglobulin receptors includes activating (CD300b, CD300e) and inhibitory members (CD300a, CD300f), as well as molecules presenting a negative charge within their transmembrane domain (CD300c, CD300d). It is expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granu... | |||
TMPK-00212 |
CD300A Protein, Mouse, Recombinant (His)
MAIR-I,IGSF12,IRp60,Mcipr1,CLM8,NKRL,IRC1,CD300a,Pigr4,CLM-8... |
Mouse | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Mouse, Recombinant (His) is expressed in HEK293 mam... | |||
TMPJ-00542 |
TPSB2 Protein, Human, Recombinant (His)
Tryptase-2,Tryptase Beta-2,TPS2,TPSB2,Tryptase II,Tryptase β... |
Human | HEK293 Cells |
Tryptases are Trypsin-like Serine Proteases. β-Tryptases are the main isoenzymes in mast cells. Βtryptases form active tetramers with heparin proteoglycan. In the tetramer, the unique arrangement of the active sites facing a narrow central pore, β-Tryptases are resistant to macromolecule protease inhibitors . When mast cells are activated, β-Tryptases are released and participate in provoking inflammatory conditions . β-Tryptases have been implicated as mediators in the pathogenesis of asthma an... | |||
TMPK-00187 |
CD300A Protein, Human, Recombinant (Avi), Biotinylated
Pigr4,LMIR1,IGSF12,CLM-8,CD300a,CLM8,IRC1,MAIR-I,Mcipr1,IRp6... |
Human | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Human, Recombinant (Avi), Biotinylated is expressed... | |||
TMPK-00561 |
CD300A Protein, Cynomolgus, Recombinant (His)
Mcipr1,IGSF12,IRp60,LMIR1,CD300a,MAIR-I,Pigr4,CLM-8,IRC1,NKR... |
Cynomolgus | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Cynomolgus, Recombinant (His) is expressed in HEK29... | |||
TMPK-00186 |
CD300A Protein, Human, Recombinant (Avi)
Mcipr1,CLM-8,MAIR-I,IGSF12,NKRL,LMIR1,CLM8,IRC1,IRp60,CD300a... |
Human | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Human, Recombinant (Avi) is expressed in HEK293 mam... | |||
TMPK-00559 |
CD300A Protein, Cynomolgus, Recombinant (Avi)
LMIR1,NKRL,CLM8,Mcipr1,Pigr4,IGSF12,MAIR-I,IRp60,IRC1,CLM-8,... |
Cynomolgus | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Cynomolgus, Recombinant (Avi) is expressed in HEK29... | |||
TMPK-00560 |
CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated
IGSF12,Mcipr1,NKRL,IRp60,LMIR1,Pigr4,MAIR-I,CLM-8,CD300a,CLM... |
Cynomolgus | HEK293 Cells |
CD300a is an inhibitory receptor for mast cells and eosinophils in allergic inflammation (AI); however, the spatiotemporal expression of CD300a and its potential roles in the resolution of AI are still to be determined.CD300a expression on peritoneal cells is regulated from inflammation to resolution. CD300a activation on mouse bone marrow-derived mast cells regulated ALX/FPR2 expression levels following IgE-mediated activation. CD300A Protein, Cynomolgus, Recombinant (Avi), Biotinylated is expr... | |||
TMPH-03396 |
TPSAB1 Protein, Rat, Recombinant (His & Myc & SUMO)
|
Rat | E. coli |
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSAB1 Protein, Rat, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 47.4 kDa and the accession number is P27435. | |||
TMPY-03968 |
Secretogranin II Protein, Human, Recombinant (His)
EM66,SgII,SN,CHGC,secretogranin II |
Human | HEK293 Cells |
Kit ligand, also known as Hematopoietic growth factor KL, Mast cell growth factor, Steel factor, Stem cell factor, c-Kit ligand, Kitlg and KITL, is a single-pass type I membrane protein that belongs to the SCF family. KITL / kit ligand also belongs to the family of dimeric transmembrane growth factors. The soluble form of KIT ligand is a secreted protein. Mast cells are thought to participate in a variety of immune responses, such as parasite resistance and the allergic reaction. Mast cell devel... | |||
TMPH-02258 |
TPSB2 Protein, Human, Recombinant (E. coli, His)
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Human | E. coli |
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSB2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.4 kDa and the accession number is P20231. | |||
TMPH-02957 |
TPSAB1 Protein, Mouse, Recombinant (His)
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Mouse | E. coli |
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSAB1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 30.1 kDa and the accession number is Q02844. | |||
TMPH-03328 |
Mcpt1 Protein, Rat, Recombinant (Myc)
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Rat | E. coli |
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. May participate in generating perivascular beta-protein which ultimately aggregates into amyloid-beta deposits. Mcpt1 Protein, Rat, Recombinant (Myc) is expressed in E. coli expression system with N-Myc tag. The predicted molecular weight is 28.6 kDa and the accession number is P09650. | |||
TMPH-00064 |
MRJP1 Protein, Apis mellifera, Recombinant (His)
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Apis mellifera | P. pastoris (Yeast) |
Induces the differentiation of honeybee larvae into queens through an Egfr-mediated signaling pathway. Promotes body size increase by activating p70 S6 kinase, stimulates ovary development by augmenting the titer of vitellogenin (Vg) and juvenile hormone, and reduces developmental time by increasing the activity of mitogen-activated protein kinase and inducing the 20-hydroxyecdysone protein (20E). Most abundant protein found in the royal jelly which is the food of the queen honey bee larva. The ... | |||
TMPH-02257 |
TPSB2 Protein, Human, Recombinant (His & Myc)
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Human | P. pastoris (Yeast) |
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. TPSB2 Protein, Human, Recombinant (His & Myc) is expressed in yeast with C-6xHis-Myc tag. The predicted molecular weight is 31.2 kDa and the accession number is P20231. | |||
TMPK-01303 |
TPSAB1 protein, Cynomolgus, Recombinant (His)
Tryptase alpha/beta-1,TPSB1,Tryptase I,TPS2,TPS1,Tryptase al... |
Cynomolgus | E. coli |
TPSAB1, namely tryptase alpha/beta-1, is a serine protease with trypsinlike activity. TPSAB1 is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. It may play a role in innate immunity. Diseases associated with TPSAB1 include mastocytosis and systemic mastocytosis. | |||
TMPH-03267 |
CD300f/CD300LF Protein, Rat, Recombinant (His & Myc & SUMO)
Clm1,Cd300lf,CD300 antigen-like family member F,CLM-1,CD300f... |
Rat | E. coli |
Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell ... | |||
TMPK-00049 |
IL-3 Protein, Mouse, Recombinant (hFc)
IL3,MULTI-CSF,MCGF,白细胞介素,IL-3MGC79398,IL-3,白介素,interleukin-3 |
Mouse | HEK293 Cells |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 42.2 kDa and the accession num... | |||
TMPK-00590 |
IL-3 Protein, Human, Recombinant (E. coli)
interleukin-3,IL-3,MULTI-CSF,MCGF,IL-3MGC79398,IL3 |
Human | E. coli |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Human, Recombinant(E. coli) is expressed in E. coli expression system. The predicted molecular weight is 15.09 kDa and the accession number is A... | |||
TMPK-00032 |
IL-3 Protein, Human, Recombinant (His & Avi), Biotinylated
白细胞介素,白介素,interleukin-3,MULTI-CSF,IL-3,IL3,IL-3MGC79398,MCGF |
Human | E. coli |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 16.... | |||
TMPK-00655 |
IL-3 Protein, Cynomolgus, Recombinant (His)
MCGF,IL3,MULTI-CSF,IL-3MGC79398,interleukin-3,IL-3 |
Cynomolgus | E. coli |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Cynomolgus, Recombinant (His) is expressed in E. coli expression system with N-His tag. The predicted molecular weight is 15.13 kDa and the acce... | |||
TMPJ-00233 |
CD200R1/CRTR2 Protein, Human, Recombinant (His)
Cell Surface Glycoprotein CD200 Receptor 1,OX2R,MOX2R,CD200 ... |
Human | HEK293 Cells |
Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. CD200R1 and CD200 associate via their respective N-terminal Ig-like domains. CD200R1 is restricted primarily to mast cells, basophils, macrophages, and dendritic cells. It propagates inhibitory signals despite its lacking a cytopla... | |||
TMPK-00026 |
IL-9 Protein, Mouse, Recombinant (hFc)
P40,IL-9,Interleukin-9,Cytokine P40,T-cell growth factor P40... |
Mouse | HEK293 Cells |
IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Mouse, Re... | |||
TMPK-00033 |
IL-3 Protein, Human, Recombinant (hFc)
IL3,interleukin-3,IL-3,MULTI-CSF,白介素,白细胞介素,IL-3MGC79398,MCGF |
Human | HEK293 Cells |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 41.6 kDa and the accession num... | |||
TMPK-00031 |
IL-3 Protein, Human, Recombinant (His & Avi)
IL-3,IL3,IL-3MGC79398,白介素,interleukin-3,MULTI-CSF,白细胞介素,MCGF |
Human | E. coli |
Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes. IL-3 Protein, Human, Recombinant (His & Avi) is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 16.9 kDa and the ... | |||
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