Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with Antitumor avtivity.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,500 | 6-8周 | ||
50 mg | ¥ 13,700 | 6-8周 | ||
100 mg | ¥ 17,400 | 6-8周 |
产品描述 | Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with Antitumor avtivity. |
靶点活性 | MMP1:79 nM, MMP2:0.05 nM (ki), MMP13:0.3 nM (ki), MMP13:6.3 nM, MMP9:0.26 nM (ki), MMP9:5 nM |
体外活性 | Prinomastat inhibits Wnt1-induced MMP-3 production. Reversal of Wnt1-induced EMT and β-catenin transcriptional activity by Prinomastat[1]. |
体内活性 | Prinomastat has good tumour growth inhibition, with a short T1/2 of 1.6 hours[1]. |
别名 | KB-R9896 hydrochloride, AG3340 hydrochloride |
分子量 | 459.97 |
分子式 | C18H22ClN3O5S2 |
CAS No. | 1435779-45-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (217.41 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1741 mL | 10.8703 mL | 21.7405 mL | 54.3514 mL |
5 mM | 0.4348 mL | 2.1741 mL | 4.3481 mL | 10.8703 mL | |
10 mM | 0.2174 mL | 1.087 mL | 2.1741 mL | 5.4351 mL | |
20 mM | 0.1087 mL | 0.5435 mL | 1.087 mL | 2.7176 mL | |
50 mM | 0.0435 mL | 0.2174 mL | 0.4348 mL | 1.087 mL | |
100 mM | 0.0217 mL | 0.1087 mL | 0.2174 mL | 0.5435 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Prinomastat hydrochloride 1435779-45-5 Proteases/Proteasome MMP KB-R9896 hydrochloride KB-R-9896 Hydrochloride Prinomastat Hydrochloride AG3340 hydrochloride AG-3340 Hydrochloride AG3340 Hydrochloride KB-R 9896 Hydrochloride AG 3340 Hydrochloride KB-R9896 Hydrochloride Inhibitor inhibitor inhibit