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97

抑制剂 & 化合物

24

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1866	AT-56	Others; PGE Synthase	Immunology/Inflammation; Others
	AT56 是口服有活性的脂钙蛋白型前列腺素 D 合酶 (L-PGDS) 选择性抑制剂，其IC50=95 μM，Ki=75 μM。它能够特异性地抑制L-PGDS 催化的 PGD2介导的嗜睡或疼痛反应。
T8674	SR33805	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	SR33805 是钙通道拮抗剂，在去极化和极化条件下的 EC50值分别为 4.1 和 33 nM。它阻止 L 型 Ca2+通道，可用于研究急性或慢性心脏衰竭。
T0145	Felodipine 非洛地平,CGH-869	Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Felodipine (CGH-869) 是一种长效的 1, 4-二氢吡啶钙通道抑制剂，可跨越血脑屏障，可诱导自噬，具有抗高血压活性。它通过选择性作用于血管平滑肌，尤其是阻力血管来降低血压。
T0957	Isradipine PN 200-110,伊拉地平	Calcium Channel; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Isradipine (PN 200-110) 是一种二氢吡啶类钙通道阻滞剂，具有抗高血压和血管扩张活性。它是一种具有口服活性的 L 型钙通道阻滞剂，也是一种潜在可行的帕金森病神经保护剂。
T6777	Bay K 8644 (±)-BAY-K-8644,SQ 28,873	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Bay K 8644 (SQ 28,873)是一种二氢吡啶化合物，是一种选择性的 L 型 Ca2+ 通道激活剂，IC50 为 17.3 nM。它通过增加通道的开放时间来增加通过肌膜 Ca2+通道的 Ca2+流入。
T1101	Minocycline hydrochloride Minocycline HCl,盐酸米诺环素,美满霉素	HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic	Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Minocycline hydrochloride (Minocycline HCl) 是四环素抗生素，具有出色的吸收和组织渗透性，可用于多种细菌感染以及痤疮的治疗。米诺环素可导致在开始治疗后 1 至 3 个月内发生的急性肝炎样综合征或通常在长期治疗后具有自身免疫特征的更隐匿的慢性肝炎。
T12032	Mibefradil dihydrochloride 盐酸米贝地尔,Ro 40-5967 (dihydrochloride),米贝拉地尔	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Mibefradil dihydrochloride (Ro 40-5967 (dihydrochloride)) 是一种钙离子通道抑制剂，选择性作用于 T 型 Ca2+通道，对 T 型和 L 型通道的IC50分别为 2.7 和 18.6 μM。
T15301	Fluspirilene Redeptin,R 6218	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Fluspirilene (R 6218) 是一种非竞争性 L 型钙通道拮抗剂(IC50：0.03 μM)。Fluspirilene 是一种长效抗精神病类疾病的化合物，用于治疗精神分裂症。
T23301	(S)-(+)-Niguldipine hydrochloride	Others	Others
	L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist
T22788	FPL64176 FPL 64176	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	FPL64176 是一种非二氢吡啶类L 型钙通道激动剂，EC50值为 16 nM。
T25702	Levovirin ICN 17261,L-Ribavirin,ICN-17261,ICN17261
	Levovirin is a monocyclic L-nucleosides with type 1 cytokine-inducing activity. Levovirin is the L-enantiomer of Ribavirin. Levovirin has similar immunomodulatory activity but does not have direct antiviral activity or hemolytic anemia.
T2323	Efonidipine (±)-Efonidipine,NZ-105,依福地平	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Efonidipine (NZ-105) 是一种二氢吡啶类钙通道阻滞剂，可阻断 T 型和 L 型钙通道。
T15244	Ertugliflozin L-pyroglutamic acid 埃格列净,PF-04971729 L-pyroglutamic acid	Others; SGLT	GPCR/G Protein; Others
	Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) 是一种特异性和口服活性的 hSGLT2 抑制剂，IC50 为 0.877 nM。 Ertugliflozin L-pyroglutamic acid 可用于治疗 2 型糖尿病的研究。
T68055	Devapamil Devapamilo,Devapamilum	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Devapamil (Devapamilo) 是一种苯烷基胺，以使用依赖性方式阻断来自膜细胞内侧的 L 型钙电流。
T6571	Lomerizine dihydrochloride Terranas,盐酸洛美利嗪,Lomerizine 2HCl,Lomerizine hydrochloride,KB-2796	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Lomerizine dihydrochloride (KB-2796) 是双重 L 和 T 型电压门控钙通道拮抗剂。
T16339	Norverapamil hydrochloride (±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米	Calcium Channel; P-gp; Drug Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Norverapamil hydrochloride (D591 hydrochloride) 是 Verapamil 的 N-去甲基代谢物，是 L 型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。
T0388	Cilnidipine FRC-8653,西尼地平	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Cilnidipine (FRC-8653) 是二氢吡啶类Ca2+通道阻断剂，可作用于 L 和 N 型 Ca2+通道，具有抗高血压活性。
TQ0144	(S)-(-)-Bay-K-8644 (S)-(-)-Bay K 8644	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	(S)-(-)-Bay-K-8644 ((S)-(-)-Bay K 8644) 是 L 型 Ca2+ 通道的激动剂，可激活 Ba2+ 电流，其EC50 为 32 nM。
T32490	L-161240 L-161,240	Antibacterial	Microbiology/Virology
	L-161240 是一种与脂质A生物合成有关的抗菌剂，在DEACET测定IC50值为 30 nM，并且对野生型大肠杆菌的MIC值为1-3μg/ mL。
T11727	JPH203 dihydrochloride KYT-0353 dihydrochloride	Others	Others
	JPH203 dihydrochloride (KYT-0353 dihydrochloride) 是一种酪氨酸类似物，可作为 L 型氨基酸转运蛋白 1 (LAT1) 的选择性抑制剂，用于癌症研究。
TQ0139	VU 0240551 N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide,VU0240551-2-D4	Potassium Channel; Calcium Channel; HER	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Metabolism; Tyrosine Kinase/Adaptors
	VU 0240551 是神经元 K-Cl 协同转运蛋白 KCC2 抑制剂的特异性拮抗剂，IC50 为 560 nM。 VU 0240551 抑制 L 型钙通道和 hERG。
T8591	RNase L-IN-2 5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one	Others	Others
	RNase L-IN-2 是 RNase L 的激活剂，EC50 为 22 uM；对多种类型的 RNA 病毒（包括人类病原体人类副流感病毒 3 型）具有广谱抗病毒活性，在有效浓度下没有细胞毒性。
T21263	Amlodipine maleate Amlodipine (+-)-form maleate,Amvaz	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Amlodipine maleate (Amvaz) 是一种具有口服活性的二氢吡啶类钙通道阻滞剂，通过阻滞电压依赖性 L 型钙通道，从而抑制钙离子内流。Amlodipine maleate 可用于研究高血压和癌症。
T62769	Tribendimidine	AChR	Neuroscience
	Tribendimidine 是一种广谱的、口服具有活力的驱虫剂，也是一种 L 型烟碱乙酰胆碱受体 (nAChR) 激动剂。Tribendimidine 对 A. lumbricoides 和 N. americanus 具有极高的活性。
T0999	Clevidipine Clevidipine butyrate,丁酸氯维地平,氯维地平,Cleviprex	Calcium Channel; AChR	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Clevidipine (Clevidipine butyrate) butyrate 是一种二氢吡啶 L 型钙通道阻滞剂，IC50为7.1 nM。它对血管平滑肌有选择性，可用于降低血压。
T27205	DPI 201-106 DPI-201-106	Sodium Channel	Membrane transporter/Ion channel
	DPI 201-106对电压门控钠通道的有心脏选择性调节活性，从而产生正性肌力作用。DPI 201-106 具有协同肌膜和细胞内作用机制。
T16240	N,N'-Diacetyl-L-cystine (Ac-Cys-OH)2,DiNAC	Others	Others
	N,N'-Diacetyl-L-cystine (DiNAC) 是一种具有免疫调节特性的 N-乙酰基半胱氨酸的二硫二聚体。它在高脂血症兔中也具有抗动脉粥样硬化的作用。它是啮齿类动物中接触敏感/迟发型超敏反应的有效口服活性调节剂。
T7334	NP118809 39-1B4,1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	NP118809 (39-1B4) 是 N 型钙通道阻滞剂，IC50值为 0.11 μM。它较弱地抑制 L 型钙通道，IC50值为 12.2 μM。
T68123	Oxodipine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Oxodipine 是一种二氢吡啶型钙拮抗剂，抑制了KCl 诱导的兔主动脉收缩，降低了效力较低的大鼠心室试纸收缩的心脏力量。在大鼠培养的新生儿心室肌细胞中，Oxodipine 降低了L 型Ca 电流（I），IC 为0.24μM，对T 型Ca 电流（I）的IC 为0.41μM。Oxodipine 会使小鼠便秘和狗牙龈增生。
T30251	AZD-1305 UNII-CZO834LXQM,AZD 1305	Others	Others
	AZD-1305是一种新型抗心律失常化合物，主要阻断哺乳动物细胞和心室心肌细胞中 IKr 的快速组分、l 型钙电流和病房内钠电流，可用于研究逆转心律失常。
TQ0081	JPH203 KYT-0353	Others	Others
	JPH203 (KYT-0353) 是一种 L 型氨基酸转运蛋白 1 (LAT-1) 的抑制剂，具有有效性和特异性。JPH203 可以抑制细胞对亮氨酸的摄取，抑制细胞增殖、诱导细胞凋亡，具有抗炎和抗肿瘤活性。
T0163	Nisoldipine 尼索地平,BAY-k 5552	Calcium Channel; Reactive Oxygen Species	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	Nisoldipine (BAY-k 5552) 是一种高效特异的L 型Cav1.2通道阻断剂，IC50=10 nM。
T50077	m-Nisoldipine 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate	Others	Others
	m-Nisoldipine (3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate) 是一种二氢吡啶类钙通道阻滞剂，尼索地平的衍生物，阻断心脏和平滑肌细胞中的 L-型钙通道，用于治疗高血压和心绞痛。
T15257	Etripamil MSP-2017,(-)-MSP-2017	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Etripamil (MSP-2017) 是一种短效L 型钙通道拮抗剂，可用于治疗阵发性室上性心动过速的研究。它通过抑制房室结细胞中钙慢通道的钙离子流入，显示房室结传导并延长房室结不应期
T23280	Ruthenium Red 钌红,Ammoniated ruthenium oxychloride	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Ruthenium Red (Ammoniated ruthenium oxychloride) 是一种 L 型钙电流 (ICa) 阻断剂，是一种聚阳离子染料，广泛用于电子显微镜 (EM) 下细胞、组织和营养细菌的观察。它能与磷脂和脂肪酸反应强烈，并与酸性粘多糖结合。
T7502	PF 05089771 tosylate	Sodium Channel	Membrane transporter/Ion channel
	PF 05089771 tosylate 是口服有效的、选择性的Nav1.7丙烯酰胺抑制剂。PF 05089771 tosylate 具有用于疼痛和糖尿病神经性疾病的研究。
T0030	Bupivacaine hydrochloride Vivacaine,Bupivacaine HCl,盐酸布比卡因	Sodium Channel	Membrane transporter/Ion channel
	Bupivacaine hydrochloride (Vivacaine) 是NMDA 受体抑制剂，可用于慢性疼痛的研究。它可阻断钠、L-钙和钾通道，还阻断SCN5A 通道，IC50为 69.5 μM。
TQ0153	Mibefradil 米贝地尔,Ro 40-5967	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Mibefradil is a calcium channel blocker with moderate selectivity for T-type Ca2+ channels (IC50s: 2.7 μM and 18.6 μM for T-type and L-type currents).
T80078	Calciseptin	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Calciseptine 是从黑曼巴Dendroaspis p. polylepis分离得到的天然神经毒素。含有60个氨基酸和四个二硫键，特异性阻断L型钙通道（calcium channel）[1]。
T80065	Calcicludine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Calcicludine是Dendroaspis angusticeps产毒蛋白，针对高电压激活的calcium channel（特别是L型）有抑制作用，IC50为88 nM，影响兴奋性突触传递。
T24376	L-751788 L751788,L 751788
	L-751788 is an inhibits of type 1 5alpha-reductase.
T24374	L-708906 L708906,ARRY 142886,ARRY-142886,ARRY142886,L 708906
	L-708906 is the Human Immunodeficiency Virus Type 1 inhibitor.
T32435	L 163255 L-163255,L163255,L163,255,L-163,255,L 163,255
	L 163255 is a type of growth hormone secretagogue (GHS).
T32436	L 1935 Compound l1935,L-1935,Histamine-liberator L 1935,L1935
	L 1935 is a type of powerful histamine-liberator.
T34511	Sandosaponin B
	Sandosaponin B is a olean-12-ene-type triterpene oligoglycoside isolated from kidney bean, the seed of Phaseolus vulgaris L.
T24282	L 158809 L158809,L-158,809,L-158809
	L 158809 is an antagonist of the angiotensin II type 1 receptor.
T23225	(R)-(-)-Niguldipine hydrochloride	Others	Others
	L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist
T35729	Nemadipine-A
	Nemadipine A is an L-type calcium channel blocker that induces morphological and growth defects in wild-type C. elegans and those with hypoexpression of egl-19, which encodes the only L-type calcium channel α1-subunit in the C. elegans genome. It also inhibits L-type calcium channels in chick ciliary neurons. Nemadipine A increases TRAIL-induced cytotoxicity and synergistically enhances caspase-8 and caspase-3 activation in a concentration-dependent manner in H1299 lung adenocarcinoma cells. It ...
T70036	AJG-049 HCl
	AJG-049 HCl is a calcium channel antagonist that inhibits L-type Ca2+ channels via diltiazem-binding site(s).
T25670	Lercanidipine. (R)- (-)-Lercanidipine,(R)-Lercanidipine
	Lercanidipine. (R)- is an enantiomer of antihypertensive drugs Lercanidipine. Lercanidipine acts by blocking L-type calcium channels, allowing relaxation and opening of blood vessels.

化合物

Cat.No: T1866

Target: Others, PGE Synthase

Cat.No: T8674

Target: Calcium Channel

Cat.No: T0145

Synonym: 非洛地平,CGH-869

Target: Calcium Channel, Autophagy

Cat.No: T0957

Synonym: PN 200-110,伊拉地平

Target: Calcium Channel, Autophagy

Cat.No: T6777

Synonym: (±)-BAY-K-8644,SQ 28,873

Target: Calcium Channel

Minocycline hydrochloride

Cat.No: T1101

Synonym: Minocycline HCl,盐酸米诺环素,美满霉素

Target: HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

Mibefradil dihydrochloride

Cat.No: T12032

Synonym: 盐酸米贝地尔,Ro 40-5967 (dihydrochloride),米贝拉地尔

Target: Calcium Channel

Cat.No: T15301

Synonym: Redeptin,R 6218

Target: Calcium Channel

(S)-(+)-Niguldipine hydrochloride

Cat.No: T23301

Target: Others

Cat.No: T22788

Synonym: FPL 64176

Target: Calcium Channel

Cat.No: T25702

Synonym: ICN 17261,L-Ribavirin,ICN-17261,ICN17261

Cat.No: T2323

Synonym: (±)-Efonidipine,NZ-105,依福地平

Target: Calcium Channel

Ertugliflozin L-pyroglutamic acid

Cat.No: T15244

Synonym: 埃格列净,PF-04971729 L-pyroglutamic acid

Target: Others, SGLT

Cat.No: T68055

Synonym: Devapamilo,Devapamilum

Target: Calcium Channel

Lomerizine dihydrochloride

Cat.No: T6571

Synonym: Terranas,盐酸洛美利嗪,Lomerizine 2HCl,Lomerizine hydrochloride,KB-2796

Target: Calcium Channel

Norverapamil hydrochloride

Cat.No: T16339

Synonym: (±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米

Target: Calcium Channel, P-gp, Drug Metabolite

Cat.No: T0388

Synonym: FRC-8653,西尼地平

Target: Calcium Channel

(S)-(-)-Bay-K-8644

Cat.No: TQ0144

Synonym: (S)-(-)-Bay K 8644

Target: Calcium Channel

Cat.No: T32490

Synonym: L-161,240

Target: Antibacterial

JPH203 dihydrochloride

Cat.No: T11727

Synonym: KYT-0353 dihydrochloride

Target: Others

Cat.No: TQ0139

Synonym: N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide,VU0240551-2-D4

Target: Potassium Channel, Calcium Channel, HER

Cat.No: T8591

Synonym: 5-(3-hydroxyphenyl)-8-thia-4,6-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),5-trien-3-one

Target: Others

Amlodipine maleate

Cat.No: T21263

Synonym: Amlodipine (+-)-form maleate,Amvaz

Target: Calcium Channel

Cat.No: T62769

Target: AChR

Cat.No: T0999

Synonym: Clevidipine butyrate,丁酸氯维地平,氯维地平,Cleviprex

Target: Calcium Channel, AChR

Cat.No: T27205

Synonym: DPI-201-106

Target: Sodium Channel

N,N'-Diacetyl-L-cystine

Cat.No: T16240

Synonym: (Ac-Cys-OH)2,DiNAC

Target: Others

Cat.No: T7334

Synonym: 39-1B4,1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮

Target: Calcium Channel

Cat.No: T68123

Target: Calcium Channel

Cat.No: T30251

Synonym: UNII-CZO834LXQM,AZD 1305

Target: Others

Cat.No: TQ0081

Synonym: KYT-0353

Target: Others

Cat.No: T0163

Synonym: 尼索地平,BAY-k 5552

Target: Calcium Channel, Reactive Oxygen Species

Cat.No: T50077

Synonym: 3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Target: Others

Cat.No: T15257

Synonym: MSP-2017,(-)-MSP-2017

Target: Calcium Channel

Cat.No: T23280

Synonym: 钌红,Ammoniated ruthenium oxychloride

Target: Calcium Channel

PF 05089771 tosylate

Cat.No: T7502

Target: Sodium Channel

Bupivacaine hydrochloride

Cat.No: T0030

Synonym: Vivacaine,Bupivacaine HCl,盐酸布比卡因

Target: Sodium Channel

Cat.No: TQ0153

Synonym: 米贝地尔,Ro 40-5967

Target: Calcium Channel

Cat.No: T80078

Target: Calcium Channel

Cat.No: T80065

Target: Calcium Channel

Cat.No: T24376

Synonym: L751788,L 751788

Cat.No: T24374

Synonym: L708906,ARRY 142886,ARRY-142886,ARRY142886,L 708906

Cat.No: T32435

Synonym: L-163255,L163255,L163,255,L-163,255,L 163,255

Cat.No: T32436

Synonym: Compound l1935,L-1935,Histamine-liberator L 1935,L1935

Cat.No: T34511

Cat.No: T24282

Synonym: L158809,L-158,809,L-158809

(R)-(-)-Niguldipine hydrochloride

Cat.No: T23225

Target: Others

Cat.No: T35729

Cat.No: T70036

Lercanidipine. (R)-

Cat.No: T25670

Synonym: (-)-Lercanidipine,(R)-Lercanidipine

Cat. No.	Product Name	Target	Signaling Pathways
T15700	L-Xylose L-(-)-Xylose,L-(-)木糖	Others	Others
	L-Xylose (L-(-)-Xylose) 是一种木糖的左旋结构。其中木糖是醛戊糖类型的单糖。
T3938	H-HomoArg-OH.HCl NSC 145416,L-Homoarginine hydrochloride,L-高精氨酸盐酸盐,L(+)-Homoarginine hydrochloride	Endogenous Metabolite; Phosphorylase	Metabolism
	H-HomoArg-OH.HCl (L-Homoarginine hydrochloride) 是内源性代谢产物的一种。
T13280	Valerylcarnitine VALERYL-L-CARNITINE	Endogenous Metabolite	Metabolism
	Valerylcarnitine (VALERYL-L-CARNITINE) 是一种短链脂肪酸，可用于研究 2 型糖尿病。
TQ0234	Epoxymicheliolide 1β,10β-Epoxymicheliolide,环氧木香内酯	Others	Others
	Epoxymicheliolide (1β,10β-Epoxymicheliolide) 是木香内酯衍生物的一种。
T3S1916	Heteroclitin D 异型南五味子丁素,异南五味子丁素；异型南五味子丁素	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Heteroclitin D 是异形南五味子中的一种木脂素，可抑制 L 型钙通道，具有抗脂质过氧化作用。
T3013	Catharanthine tartrate Catharanthine hemitartrate,酒石酸长春质碱	Others; Calcium Channel	Membrane transporter/Ion channel; Metabolism; Others
	Catharanthine tartrate (Catharanthine hemitartrate) 是长春花中的一种生物碱，可抑制电压门控 L 型钙离子通道，具有抗肿瘤和降血压活性。
T19340	Glutarylcarnitine O-glutaroyl-L-carnitine	Endogenous Metabolite	Metabolism
	Glutarylcarnitine (O-glutaroyl-L-carnitine) 是大多数串联质谱新生儿筛查计划中监测的丙二酸尿症和谷草酸尿症 I 型的诊断代谢物。
T2782L	Catharanthine Tartrate(2468-21-5(free base))	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Catharanthine Tartrate(2468-21-5(free base)) 是从马达加斯加长春花中分离得到的天然产物，Catharanthine Tartrate 抑制电压操作的L 型Ca2+通道，具有抗癌和降血压活性。
TN4660	Niranthin	Anti-infection; HBV; PAFR; Topoisomerase	DNA Damage/DNA Repair; GPCR/G Protein; Microbiology/Virology
	Niranthin 是一种木脂素，具有广泛的药理活性。它是L. donovaniIB 拓扑异构酶的非竞争性抑制剂，可用于研究耐药利什曼病的治疗。
T5267	N-Acetyl-L-glutamic acid Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) 是一种 N-Acyl-L-氨基酸，是动物细胞培养基的组成成分，是一种酿酒酵母和人类的代谢物。
T2215	Ferulic Acid Coniferic acid,Fumalic Acid,阿魏酸	FGFR; Endogenous Metabolite	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Ferulic Acid (Coniferic acid) 是新型的成纤维细胞生长因子受体 1 (FGFR1)抑制剂, 在FGFR1和FGFR2的IC50分别为 3.78 和 12.5 μM。
TCS0102	Pulegone 胡薄荷酮,(+)-Pulegone,蒲勒酮，胡薄荷酮，长叶薄荷酮	Calcium Channel; Endogenous Metabolite; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	Pulegone ((+)-Pulegone) 是 Calamintha nepeta (L.) Savi 的精油的主要化学成分，也是禽类驱虫剂之一。它在禽类物种中驱避作用的分子靶点是伤害感受性 TRP 锚蛋 1。它刺激鸡感觉神经元中的 TRPM8 和 TRPA1 通道，并在高浓度下抑制前者但不抑制后者。
T25253	Cinnamtannin B-1 Cinnamtannin B1 (constituent of cinnamomum verum bark),LDN 0022358,LDN-0022358,LDN0022358,肉桂单宁B-1	Antioxidant; COX	Immunology/Inflammation; Neuroscience; oxidation-reduction
	Cinnamtannin B-1 (LDN 0022358) 是一种 A 型原花青素，包含在多种植物中，如越桔、桂树、泽兰肉桂和猪苓。它是一种有效的抗氧化剂和保护剂，可对抗人类血小板的氧化应激和凋亡。它是一种 Cox-2抑制剂。
T8787	Drotaverine hydrochloride	PDE	Metabolism
	Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂，也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂，可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果，但无抗胆碱能的效果。
TN1065	Hirsutine	Apoptosis	Apoptosis
	Hirsutine 是一种来自钩藤的吲哚生物碱，可诱导细胞凋亡，是一种登革热病毒抑制剂，且毒性低。它具有抗癌、心脏保护、抗高血压、抗心律失常和血管舒张活性。
T8274	3-Methyl-L-histidine	Endogenous Metabolite	Metabolism
	3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
T38954	L-Glyceric acid sodium
	L-Glyceric acid sodium is a urinary metabolite predominantly found in individuals with the rare inherited metabolic disorder, L-glyceric aciduria. This compound serves as a diagnostic tool for identifying primary hyperoxaluria type 2 (PH2) and can be used to differentiate between PH1 and PH2 based on its excretion pattern.
T82182	Hosenkoside L
	Hosenkoside L是一种从植物中提取的糖苷。
TN1797	Isorhoifolin	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Isorhoifolin and vicenin II are main compounds of ethyl acetate fraction (EAcF) obtained from Erythrina velutina leaves, EAcF increases the cardiac contractile force by increasing the l-type calcium current and activating the adrenergic receptor pathway.
TN5234	Vindorosine	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles.
T79934	Clavirolide L
	Clavirolide L (Compound 3)为多拉贝烷二萜类化合物，源自Clavularia viridis。该化合物对HIV-1具有显著抑制效果，同时不针对RT酶，适用于HIV感染的研究。
TN2534	1-Hydroxy-2,3,5-trimethoxyxanthone	IκB/IKK; Calcium Channel; NOS; 5-HT Receptor; COX	GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels; a minor contribution to the effects of HM-1 may be related to inhibition of the protein kinase C-mediated release of intracellular Ca(2+) stores. HM-1,at the concentration of 1 ug/mL, can effectively inhibit the osteoclast differentiation in a co-c...
T36563	(E)-Guggulsterone
	Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...
T37452	Stephacidin B
	Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc...

天然产物

Cat.No: T15700

Synonym: L-(-)-Xylose,L-(-)木糖

Target: Others

H-HomoArg-OH.HCl

Cat.No: T3938

Synonym: NSC 145416,L-Homoarginine hydrochloride,L-高精氨酸盐酸盐,L(+)-Homoarginine hydrochloride

Target: Endogenous Metabolite, Phosphorylase

Valerylcarnitine

Cat.No: T13280

Synonym: VALERYL-L-CARNITINE

Target: Endogenous Metabolite

Epoxymicheliolide

Cat.No: TQ0234

Synonym: 1β,10β-Epoxymicheliolide,环氧木香内酯

Target: Others

Cat.No: T3S1916

Synonym: 异型南五味子丁素,异南五味子丁素；异型南五味子丁素

Target: Calcium Channel

Catharanthine tartrate

Cat.No: T3013

Synonym: Catharanthine hemitartrate,酒石酸长春质碱

Target: Others, Calcium Channel

Glutarylcarnitine

Cat.No: T19340

Synonym: O-glutaroyl-L-carnitine

Target: Endogenous Metabolite

Catharanthine Tartrate(2468-21-5(free base))

Cat.No: T2782L

Target: Calcium Channel

Cat.No: TN4660

Target: Anti-infection, HBV, PAFR, Topoisomerase

N-Acetyl-L-glutamic acid

Cat.No: T5267

Synonym: Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid

Target: Others, Endogenous Metabolite

Cat.No: T2215

Synonym: Coniferic acid,Fumalic Acid,阿魏酸

Target: FGFR, Endogenous Metabolite

Cat.No: TCS0102

Synonym: 胡薄荷酮,(+)-Pulegone,蒲勒酮，胡薄荷酮，长叶薄荷酮

Target: Calcium Channel, Endogenous Metabolite, TRP/TRPV Channel

Cinnamtannin B-1

Cat.No: T25253

Synonym: Cinnamtannin B1 (constituent of cinnamomum verum bark),LDN 0022358,LDN-0022358,LDN0022358,肉桂单宁B-1

Target: Antioxidant, COX

Drotaverine hydrochloride

Cat.No: T8787

Target: PDE

Cat.No: TN1065

Target: Apoptosis

3-Methyl-L-histidine

Cat.No: T8274

Target: Endogenous Metabolite

L-Glyceric acid sodium

Cat.No: T38954

Cat.No: T82182

Cat.No: TN1797

Target: Adrenergic Receptor

Cat.No: TN5234

Target: Calcium Channel, Sodium Channel

Cat.No: T79934

1-Hydroxy-2,3,5-trimethoxyxanthone

Cat.No: TN2534

Target: IκB/IKK, Calcium Channel, NOS, 5-HT Receptor, COX

(E)-Guggulsterone

Cat.No: T36563

Cat.No: T37452

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