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Search Results for " 5-lipoxygenase "

128

抑制剂 & 化合物

19

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T10151	5-Lipoxygenase-In-1	Lipoxygenase	Metabolism
	5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor.
T8356	FPL 62064	Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience
	FPL 62064 是 5-脂氧合酶和COX 双重抑制剂，具有抗炎活性，对 RBL-1 胞质 5-脂氧合酶和前列腺素合成酶 (环氧化酶) 的IC50值分别为 3.5 和 3.1 μM。
T75122	5-Lipoxygenase-IN-3
	5-Lipoxygenase-IN-3 (Compound 14) 是一种5-Lipoxygenase 抑制剂 (IC50: <1 μM)。5-Lipoxygenase-IN-3 可用于炎症性疾病、癌症、中风和阿尔茨海默病的研究。
T16802	Lonapalene RS4317,氯萘帕林	Others	Others
	Lonapalene is a topically effective inhibitor of 5-lipoxygenase.
T22054	BW 755C	Lipoxygenase	Metabolism
	BW 755C 是 5-脂氧合酶 (5-LO) 和环氧合酶 (COX) 通路的双重抑制剂。
T61211	5-LOX-IN-1	Lipoxygenase	Metabolism
	5-LOX-IN-1 是一种 5-Lipoxygenase(5-LOX)抑制剂（IC50： 2.3 μM）。5-LOX-IN-1 可用于研究癌症。
T12784	RWJ 63556 RWJ-63556	Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience
	RWJ 63556 是一种可口服的 COX-2 selective/5-lipoxygenase 抑制剂，具有抗炎活性。
T27244	Efletirizine UCB 28754,UCB-28754,UCB28754	Lipoxygenase; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Efletirizine (UCB-28754) 是一种组胺受体拮抗剂，对5-脂氧合酶(5-LO)具有抑制作用，对可用于局部治疗过敏疾病。
T8950	CAY10698	Lipoxygenase	Metabolism
	CAY10698 是选择性的12-Lipoxygenase (12-LOX)抑制剂，IC50=5.1 μM。它对 5-LOX、15-LOX-1、15-LOX-2 和 COX-1/2 无活性。
T16817	S-2474	Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience
	S-2474 是 COX-2 和 5-脂氧合酶的抑制剂，具有抗炎活性和神经保护活性，可抑制 Abeta（25 - 35）和 Abeta（1 - 40）诱导的细胞死亡。
T9023	Atuliflapon AZD5718	FLAP	Immunology/Inflammation
	Atuliflapon (AZD5718) 是可口服的FLAP(5 -脂氧合酶激活蛋白)的抑制剂，IC50值为 2 nM，可用于冠状动脉疾病的研究。
T10098	PGS-IN-1 KME-4	Lipoxygenase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	PGS-IN-1 (KME-4)是一种前列腺素合成酶抑制剂，IC50=0.28 μM。它也可抑制5-脂肪氧合酶的活性，IC50=1.05 μM。
T16503	PF-4191834 PF-04191834	Lipoxygenase	Metabolism
	PF-4191834 是 5-Lipoxygenase (5-LOX) 的非铁螯合和非氧化还原抑制剂，IC50 为 229 nM。 PF-4191834 对 5-LOX 的特异性比 12-LOX 和 15-LOX 高约 300 倍，并且对环氧合酶没有活性。 PF-4191834 可用于炎症和疼痛的研究。
T25737	Linetastine TMK 688,TMK-688,TMK688	Lipoxygenase; LTR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Linetastine (TMK-688) 是一种 5-脂氧合酶抑制剂(5-LOX)，能抑制白三烯的产生，并能拮抗组胺的作用。Linetastine可用于研究哮喘、动脉粥样硬化和消化性溃疡。
T22358	Etalocib LY293111,VML295	Apoptosis; Leukotriene Receptor; LTR	Apoptosis; GPCR/G Protein; Immunology/Inflammation
	Etalocib (LY293111) 是一种具有口服活性的白三烯(LTB4)受体的拮抗剂，抑制 [3H]LTB4结合的 Ki 值为 25 nM。它还可诱导凋亡。它抑制 LTB4诱导的钙动员，lC50值为 20 nM。
T70188	ER-34122	Lipoxygenase	Metabolism
	ER-34122，一种新型可口服的双重 5-脂氧合酶/环氧合酶抑制剂，在花生四烯酸诱导的耳部炎症模型中具有强大的抗炎活性。
TQ0159	U-73343 U 73343	Phospholipase	Metabolism
	U-73343 是一种 U-73122 的无活性类似物，能够剂量依赖性的抑制酸分泌，可作为 U-73122 的阴性对照。其中 U 73122 是一种有效的磷脂酶 C (phospholipase C) 和 5-脂氧合酶 (5-LO (5-lipoxygenase)) 抑制剂，对磷脂酶 C 的 IC50值约为 1-2.1 µM。
T22502	2-TEDC	Lipoxygenase	Metabolism
	2-TEDC 是一种有效的脂氧合酶（LOX）抑制剂，对 5-LOX、12-LOX 和 15-LOX 具有抑制作用，IC50 值分别为 0.09 μM、0.013 μM 和 0.5 μM。2-TEDC 可用于研究动脉粥样硬化。
T9878	Croconazole	Lipoxygenase; LTR	Immunology/Inflammation; Metabolism
	Croconazole 对中性粒细胞的 5-脂氧合酶 (5-LOX) 表现出剂量依赖性抑制活性。Croconazole 是一种抗真菌剂。Croconazole 对合成白三烯 B4 (LTB4) 和 5-羟基二十碳四烯酸 (5-HETE) 的 IC50 分别为 7.8 ± 1.7 和 7.6 ± 0.3 μM。
T11487	Fiboflapon GSK2190915,AM-803	FLAP	Immunology/Inflammation
	Fiboflapon (GSK2190915) 是一种可口服且具有有效性 5-脂氧合酶激活蛋白 (FLAP) 抑制剂，结合 FLAP 的效价为 2.9 nM，对人血中 LTB4 有抑制作用， IC50 值为 76 nM。
T10208	A-69412 N-1-(Fur-3-ylethyl)-N-hydroxyurea	Lipoxygenase	Metabolism
	A-69412 (N-1-(Fur-3-ylethyl)-N-hydroxyurea) 是一种特异性的 5-脂氧合酶 (5-LO) 的可逆抑制剂。 A-69412 能用于哮喘和溃疡性结肠炎，以及其他炎症和过敏症状的研究。
T0477	Zileuton Abbott 64077,齐留通,A 64077	Ferroptosis; Lipoxygenase; COX	Apoptosis; Immunology/Inflammation; Metabolism; Neuroscience
	Zileuton (A 64077) 是羟基脲的合成衍生物，是一种选择性的5-脂氧合酶抑制剂，具有平喘特性。
T8844	Diflapolin	Others; FLAP; Epoxide Hydrolase	Immunology/Inflammation; Metabolism; Others
	Diflapolin 是高活性的双 5-脂氧合酶激活蛋白(FLAP)/可溶性环氧化物水解酶抑制剂，具有显著的抗炎作用和较高的靶向选择性。它抑制分离的 sEH 的活性，IC50为20 nM。它还抑制完整人单核细胞和中性粒细胞中 5-LOX 产物的形成，IC50分别为 30 和 170 nM。
T68173	ZD-2138 Ici-D2138	Lipoxygenase	Metabolism
	ZD-2138是一种有效且具有选择性的5-脂氧合酶（5-LOX）的特异性抑制剂，抑制了过敏原诱导的肺支气管收缩，可减少豚鼠孤立气道的神经诱发性快速激肽能收缩。ZD-2138可用来治疗哮喘疾病。
T77528	5-LOX-IN-2	Apoptosis; Lipoxygenase	Apoptosis; Metabolism
	5-LOX-IN-2 是一种 5-脂氧合酶抑制剂 (5-LOX )抑制剂，从体外实验测得的IC50 值为 0.33 μM。5-LOX-IN-2 以剂量依赖的方式抑制 5-LOX发挥作用。5-LOX-IN-2 可降低肾癌细胞的细胞活性并诱导凋亡 (apoptosis)，可用于研究癌症。
T7724	Tepoxalin RWJ-20485,RWJ20485,ORF20485,替泊沙林,ORF-20485,RWJ 20485,ORF 20485	Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience
	Tepoxalin (RWJ 20485) 是有效的5-脂氧合酶和环氧合酶抑制剂，表现出强大的抗炎活性和较小的胃肠道刺激性。
T4657	WHI-P97 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	WHI-P97 是一种选择性 JAK-3抑制剂，可用于预防过敏性哮喘的研究。
T6893	MK-886 MK886,L 663536	Apoptosis; Leukotriene Receptor; COX; PPAR; FLAP	Apoptosis; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	MK-886 (L 663536)是一种细胞可渗透的，具有口服活性的 FLAP (IC50为 30 nM) 和白三烯生物合成 (完整白细胞和人全血中的IC50分别为 3 nM 和 1.1μM) 的抑制剂。它也是一种非竞争性PPARα拮抗剂，可以诱导细胞凋亡。
T68037L	CBS-1114 HCl N-Phenylbenzamidrazone hydrochloride,cbs-1114 HCl(46721-85-1 Free base)	Lipoxygenase	Metabolism
	CBS-1114 HCl (N-Phenylbenzamidrazone hydrochloride) 是一种5-脂氧合酶抑制剂，是一种良好眼睛渗透型号的抗炎化合物。CBS-1114 HCl 可以保持和改善心脏功能，减轻心功能障碍，以及减少患有心血管疾病的受试者的心外膜脂肪组织和/或心包脂肪组织。
T21902	ML351	Lipoxygenase	Metabolism
	ML351 是一种高度特异的15-LOX-1抑制剂，其 IC50=200 nM。它对 T1D 非肥胖糖尿病小鼠模型的血糖异常和β细胞氧化应激有抑制作用。它对相关同工酶 (5-LOX、血小板 12-LOX、15-LOX-2、绵羊 COX-1 和人 COX-2) 表现出良好的选择性(>250倍)。
T16087	Quiflapon 喹夫拉朋,MK-591	Apoptosis; FLAP	Apoptosis; Immunology/Inflammation
	Quiflapon (MK-591) 是一种选择性和特异性的FLAP 抑制剂，可诱导细胞凋亡。它也是口服白三烯生物合成抑制剂，在完整的人和诱导的大鼠多形核白细胞 PMNLs 中，其IC50值分别为 3.1 nM 和 6.1 nM。
T1482	Ciclopirox 环吡酮,HOE296b,环吡酮胺	ATPase; Ferroptosis; Antibacterial; Autophagy; Antifungal	Apoptosis; Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Ciclopirox (HOE296b) 是一种合成的抗真菌剂，可研究浅表真菌病。
T6576	Malotilate Malotilatum,NKK 105,马洛替酯,Kantec	Lipoxygenase	Metabolism
	Malotilate (Kantec) 是一种抗纤维化物质，是一种口服活性的促肝药，可选择性抑制5-lipoxygenase (5-LOX)(IC50=4.7 μM)。它通过降低肝脏乙醛水平并防止转铁蛋白保留在肝细胞中，从而预防了酒精-吡唑肝炎中肝细胞损伤的发展。
T0825	Ebselen SPI-1005,PZ-51,依布硒,CCG-39161	Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物，是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒，是HIV-1衣壳 CTD 二聚化的抑制剂，具有抗炎、抗癌和抗氧化活性。
T24338	L 689065 L-689,065,L689065,L689,065,L-689065,L 689,065
	L 689065 is a 5-lipoxygenase inhibitor.
T35310	ZM 230487 ZM230487,ICI-230487,ZM-230487,ICI230487,ICI 230487
	ZM 230487 is a 5-lipoxygenase inhibitor.
T28528	RG 6866 RG-6866,RG6866
	RG 6866 is a inhibitor of 5-lipoxygenase.
T24306	L 651896 L651896,L-651896
	L 651896 is an inhibitor of 5-lipoxygenase.
T24345	L 699333 L-699333,L699333,L699,333,L 699,333,L-699,333
	L 699333 is an effective inhibitor of 5-lipoxygenase.
T10438	AZD 4407 ZD 4407	Lipoxygenase	Metabolism
	AZD 4407 is a potent inhibitor of 5-lipoxygenase.
T11196	Enazadrem	Lipoxygenase	Metabolism
	Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
T14986	CMI977 LDP977	Others	Others
	CMI977 is a potent inhibitor of 5-Lipoxygenase (5-LO).
T28718	Sch 40120 Sch40120,Sch-40120
	Sch 40120 is an inhibitor of 5-lipoxygenase.
T70921	CGS 23885
	CGS 23885 is a 5-lipoxygenase inhibitor.
T27359	FR 110302 FR110302,FR-110302
	FR 110302 is a potent inhibitor of 5-lipoxygenase.
T15548	ICI 211965 ZM-211965	Others	Others
	ICI 211965 is a selective and orally potent of 5-Lipoxygenase (5-LPO).
T27311	Fenleuton A76745,A 767456,A-76745
	Fenleuton is a 5-lipoxygenase inhibitor.
T28674	SB 210661 SB-210661,SB210661
	SB 210661 is a potent and selective 5-lipoxygenase inhibitor.
T15783	LP117	Others	Others
	LP117 is a novel and effective inhibitor of 5-Lipoxygenase (5-LO) product synthesis (IC50: 1.1 μM).
T28907	TA-270 LS-123351,LS123351
	TA-720, a 5-lipoxygenase inhibitor, is used potentially for the treatment of asthma.

化合物

5-Lipoxygenase-In-1

Cat.No: T10151

Target: Lipoxygenase

Cat.No: T8356

Target: Lipoxygenase, COX

5-Lipoxygenase-IN-3

Cat.No: T75122

Cat.No: T16802

Synonym: RS4317,氯萘帕林

Target: Others

Cat.No: T22054

Target: Lipoxygenase

Cat.No: T61211

Target: Lipoxygenase

Cat.No: T12784

Synonym: RWJ-63556

Target: Lipoxygenase, COX

Cat.No: T27244

Synonym: UCB 28754,UCB-28754,UCB28754

Target: Lipoxygenase, Histamine Receptor

Cat.No: T8950

Target: Lipoxygenase

Cat.No: T16817

Target: Lipoxygenase, COX

Cat.No: T9023

Synonym: AZD5718

Target: FLAP

Cat.No: T10098

Synonym: KME-4

Target: Lipoxygenase, Prostaglandin Receptor

Cat.No: T16503

Synonym: PF-04191834

Target: Lipoxygenase

Cat.No: T25737

Synonym: TMK 688,TMK-688,TMK688

Target: Lipoxygenase, LTR, Histamine Receptor

Cat.No: T22358

Synonym: LY293111,VML295

Target: Apoptosis, Leukotriene Receptor, LTR

Cat.No: T70188

Target: Lipoxygenase

Cat.No: TQ0159

Synonym: U 73343

Target: Phospholipase

Cat.No: T22502

Target: Lipoxygenase

Cat.No: T9878

Target: Lipoxygenase, LTR

Cat.No: T11487

Synonym: GSK2190915,AM-803

Target: FLAP

Cat.No: T10208

Synonym: N-1-(Fur-3-ylethyl)-N-hydroxyurea

Target: Lipoxygenase

Cat.No: T0477

Synonym: Abbott 64077,齐留通,A 64077

Target: Ferroptosis, Lipoxygenase, COX

Cat.No: T8844

Target: Others, FLAP, Epoxide Hydrolase

Cat.No: T68173

Synonym: Ici-D2138

Target: Lipoxygenase

Cat.No: T77528

Target: Apoptosis, Lipoxygenase

Cat.No: T7724

Synonym: RWJ-20485,RWJ20485,ORF20485,替泊沙林,ORF-20485,RWJ 20485,ORF 20485

Target: Lipoxygenase, COX

Cat.No: T4657

Synonym: 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉

Target: JAK

Cat.No: T6893

Synonym: MK886,L 663536

Target: Apoptosis, Leukotriene Receptor, COX, PPAR, FLAP

Cat.No: T68037L

Synonym: N-Phenylbenzamidrazone hydrochloride,cbs-1114 HCl(46721-85-1 Free base)

Target: Lipoxygenase

Cat.No: T21902

Target: Lipoxygenase

Cat.No: T16087

Synonym: 喹夫拉朋,MK-591

Target: Apoptosis, FLAP

Cat.No: T1482

Synonym: 环吡酮,HOE296b,环吡酮胺

Target: ATPase, Ferroptosis, Antibacterial, Autophagy, Antifungal

Cat.No: T6576

Synonym: Malotilatum,NKK 105,马洛替酯,Kantec

Target: Lipoxygenase

Cat.No: T0825

Synonym: SPI-1005,PZ-51,依布硒,CCG-39161

Target: Phosphatase, Virus Protease, Calcium Channel, COX, HIV Protease

Cat.No: T24338

Synonym: L-689,065,L689065,L689,065,L-689065,L 689,065

Cat.No: T35310

Synonym: ZM230487,ICI-230487,ZM-230487,ICI230487,ICI 230487

Cat.No: T28528

Synonym: RG-6866,RG6866

Cat.No: T24306

Synonym: L651896,L-651896

Cat.No: T24345

Synonym: L-699333,L699333,L699,333,L 699,333,L-699,333

Cat.No: T10438

Synonym: ZD 4407

Target: Lipoxygenase

Cat.No: T11196

Target: Lipoxygenase

Cat.No: T14986

Synonym: LDP977

Target: Others

Cat.No: T28718

Synonym: Sch40120,Sch-40120

Cat.No: T70921

Cat.No: T27359

Synonym: FR110302,FR-110302

Cat.No: T15548

Synonym: ZM-211965

Target: Others

Cat.No: T27311

Synonym: A76745,A 767456,A-76745

Cat.No: T28674

Synonym: SB-210661,SB210661

Cat.No: T15783

Target: Others

Cat.No: T28907

Synonym: LS-123351,LS123351

Cat. No.	Product Name	Target	Signaling Pathways
T8260	4',5-Dihydroxyflavone	Lipoxygenase; Glucosidase	Metabolism
	4',5-Dihydroxyflavone 是大豆 LOX-1，Ki=102.6 μM。它也是一种酵母 α-葡萄糖苷酶抑制剂，IC50=66 μM。
T5714	5-O-Demethylnobiletin 5-DEMETHYLNOBILETIN,去甲基川陈皮素	Leukotriene Receptor; Lipoxygenase	GPCR/G Protein; Metabolism
	5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) 是从黄芪中分离出的多甲氧基黄酮，具有抗炎活性，可通过直接抑制 5-LOX 发挥作用，IC50为 0.1 μM。
T3S0153	Xanthatin 苍耳亭,叶黄制菌素	Apoptosis; VEGFR; Lipoxygenase; Wnt/beta-catenin; Antibacterial	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Metabolism; Microbiology/Virology; Stem Cells; Tyrosine Kinase/Adaptors
	Xanthatin 是一种从Xanthium strumarium 叶子中提取的天然产物，可诱导细胞凋亡。它抑制布鲁氏菌的IC50值为 2.63 μg/ mL，对寄生虫特异性锥虫硫磷还原酶具有不可逆的弱抑制作用。它通过抑制PGE2的合成和 5-脂氧合酶的活性而显示出抗炎活性。
TN2330	Phenethyl ferulate Caffeic Acid 3-Methyl Phenethyl Ester,阿魏酸苯乙酯,阿魏酸苯乙醇酯	Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience
	Phenethyl ferulate (Caffeic Acid 3-Methyl Phenethyl Ester) 对化学诱导的结肠癌具有化学预防特性，可增强偶氮甲烷诱导的结肠肿瘤的细胞凋亡。它抑制环氧合酶(COX) 和 5-脂氧合酶 (5-LOX) ，IC50 值分别为 4.35 和 5.75 μM。
T6S0413	Pectolinarigenin 柳穿鱼黄素,Pectolinaringenin	Others; Lipoxygenase; COX	Immunology/Inflammation; Metabolism; Neuroscience; Others
	Pectolinarigenin (Pectolinaringenin) 是 COX-2/5-LOX 的双重抑制剂，可抑制炎症病变中类花生酸的形成，具有抗炎活性。
T3399	Psoralidin	Others; Estrogen/progestogen Receptor; Reactive Oxygen Species; Lipoxygenase; Gamma-secretase; Akt; COX; Antibacterial	Cytoskeletal Signaling; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB; Others; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Psoralidin 是COX-2和5-LOX 的抑制剂，有抗癌，抗菌和抗炎作用。它显著下调NOTCH1信号传导，还极大地诱导活化氧产生。
TN1255	3-O-Acetyl-11-hydroxy-beta-boswellic acid	Lipoxygenase	Metabolism
	3-O-Acetyl-11-hydroxy-beta-boswellic acid 是 5-脂氧合酶抑制剂。
TN2068	Picrinine	Lipoxygenase	Metabolism
	Picrinine 是一种从 Alstonia scholaris 的叶子中提取出来的 Akuammiline 生物碱。 Picrinine 具有抗炎活性，通过抑制5-脂氧合酶来发挥作用。
TN1182	11-Keto-beta-boswellic acid 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸	Leukotriene Receptor; NF-κB; Lipoxygenase	GPCR/G Protein; Metabolism; NF-κB
	11-Keto-beta-boswellic acid 是来自乳香的一种五环三萜酸，具有抗炎活性和剂量依赖性心脏保护作用，主要是由于抑制5-脂氧合酶、白三烯、NF-κB 的激活和肿瘤坏死因子 α 的产生。
TN1308	6-Hydroxyflavanone	Others; Lipoxygenase; COX; GABA Receptor	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others
	6-Hydroxyflavanone 是从菖蒲叶中提取分离，通过靶向环氧合酶-2（COX-2），5-脂氧合酶（5-LOX）以及阿片类药物和 GABA-A 受体从而具有抗炎和抗神经性疼痛活性。6-Hydroxyflavanone 在链脲佐菌素诱导的糖尿病神经病变模型中具有抗伤害感受特性。
TJS0315	4-Methyldaphnetin 7,8-Dihydroxy-4-methylcoumarin,4-甲基瑞香素,DHMC,7,8-二羟基-4-甲基香豆素	Apoptosis; Lipoxygenase	Apoptosis; Metabolism
	4-Methyldaphnetin (DHMC) 是一种合成 4-甲基香豆素衍生物的前体。它对几种肿瘤细胞株具有选择性的抗增殖和诱导凋亡的作用。它能够清除自由基，显著抑制膜脂过氧化。
T6389	Anacardic Acid 漆树酸,6-pentadecylsalicylic Acid,Hydroginkgolic acid	Others; Epigenetic Reader Domain; Histone Acetyltransferase; Antibacterial	Chromatin/Epigenetic; Microbiology/Virology; Others
	Anacardic Acid (6-pentadecylsalicylic Acid) 是从腰果壳中提取液中分离到的酸类物质，是一种组蛋白乙酰转移酶抑制剂，对 p300 和 PCAF 的 IC50值分别为 ∼8.5 μM 和 ∼5 μM。
T24869	Texasin IR2,IR 2,IR-2
	Texasin is a selective inhibitor of human leukocyte 5-lipoxygenase.
TN2688	2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone	Antioxidant; Lipoxygenase	Metabolism; oxidation-reduction
	2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone 是一种天然产物，可从 Parinari hypochrysea (Chrysobalanaceae) 中提取得到。2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone 具有抗氧化活性且对脂氧合酶具有抑制作用。
T10821	Cirsiliol	Lipoxygenase	Metabolism
	Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors.
T13764	Lycopodine	Lipoxygenase; Caspase	Apoptosis; Metabolism; Proteases/Proteasome
	Lycopodine, a bioactive compound derived from Lycopodium clavatum spores, effectively inhibits the proliferation of HeLa cells through the induction of apoptosis. This process is mediated by caspase-3 activation. In refractory prostate cancer cells, Lycopodine triggers apoptosis by modulating 5-lipoxygenase and depolarizing the mitochondrial membrane potential, without altering p53 activity.
TN4088	Futoenone	PAFR	GPCR/G Protein
	Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2' site of the enzymes. Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both platelet activating factor receptor(PAF)and 5-lipoxygenase antagonist activity.
TN6458	Acetylshikonin
	Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.
T37272	9(S),12(S),13(S)-TriHOME
	9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...

天然产物

4',5-Dihydroxyflavone

Cat.No: T8260

Target: Lipoxygenase, Glucosidase

5-O-Demethylnobiletin

Cat.No: T5714

Synonym: 5-DEMETHYLNOBILETIN,去甲基川陈皮素

Target: Leukotriene Receptor, Lipoxygenase

Cat.No: T3S0153

Synonym: 苍耳亭,叶黄制菌素

Target: Apoptosis, VEGFR, Lipoxygenase, Wnt/beta-catenin, Antibacterial

Phenethyl ferulate

Cat.No: TN2330

Synonym: Caffeic Acid 3-Methyl Phenethyl Ester,阿魏酸苯乙酯,阿魏酸苯乙醇酯

Target: Lipoxygenase, COX

Pectolinarigenin

Cat.No: T6S0413

Synonym: 柳穿鱼黄素,Pectolinaringenin

Target: Others, Lipoxygenase, COX

Cat.No: T3399

Target: Others, Estrogen/progestogen Receptor, Reactive Oxygen Species, Lipoxygenase, Gamma-secretase, Akt, COX, Antibacterial

3-O-Acetyl-11-hydroxy-beta-boswellic acid

Cat.No: TN1255

Target: Lipoxygenase

Cat.No: TN2068

Target: Lipoxygenase

11-Keto-beta-boswellic acid

Cat.No: TN1182

Synonym: 11-Keto-beta-boswellic acid,11-酮基-BETA-乳香酸

Target: Leukotriene Receptor, NF-κB, Lipoxygenase

6-Hydroxyflavanone

Cat.No: TN1308

Target: Others, Lipoxygenase, COX, GABA Receptor

4-Methyldaphnetin

Cat.No: TJS0315

Synonym: 7,8-Dihydroxy-4-methylcoumarin,4-甲基瑞香素,DHMC,7,8-二羟基-4-甲基香豆素

Target: Apoptosis, Lipoxygenase

Cat.No: T6389

Synonym: 漆树酸,6-pentadecylsalicylic Acid,Hydroginkgolic acid

Target: Others, Epigenetic Reader Domain, Histone Acetyltransferase, Antibacterial

Cat.No: T24869

Synonym: IR2,IR 2,IR-2

2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone

Cat.No: TN2688

Target: Antioxidant, Lipoxygenase

Cat.No: T10821

Target: Lipoxygenase

Cat.No: T13764

Target: Lipoxygenase, Caspase

Cat.No: TN4088

Target: PAFR

Cat.No: TN6458

9(S),12(S),13(S)-TriHOME

Cat.No: T37272

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