269
47
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38298 |
Tuberculosis inhibitor 3
|
||
Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC < 0.016 μg/mL) against drug-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability[1]. | |||
T13223 |
Tuberculosis inhibitor 1
|
Others | Others |
Tuberculosis inhibitor 1 is a potent and non-cytotoxic inhibitor of trypanosoma brucei growth (EC50: 5 nM). | |||
T38359 |
Dup-721
|
Antibacterial | Microbiology/Virology |
DuP-721 是广谱的口服有效的抗菌剂,可以抑制多种临床敏感和耐药细菌,特别是结核杆菌M. tuberculosis。 | |||
T9734 |
InhA-IN-2
|
CDK | Cell Cycle/Checkpoint |
InhA-IN-2直接抑制 InhA,不需要过氧化氢酶过氧化物酶 KatG 的激活。 | |||
T3582 |
BTZ043
|
Antibacterial; Antibiotic; DprE1 | Microbiology/Virology; Others |
BTZ043 是一种 DprE1 的抑制剂,它对结核分枝杆菌 H37Rv 和耻垢分枝杆菌具有纳摩尔杀菌活性,MIC 值分别为 2.3 nM 和 9.2 nM。 | |||
T79510 |
Tuberculosis inhibitor 7
|
||
Tuberculosis inhibitor 7 (compound 2d) 为3-甲氧基-2-苯基咪唑并[1,2-b]哒嗪类衍生物,对结核分枝杆菌(MIC90为0.63 μM)及海洋分枝杆菌(MIC90为0.63 μM)具有显著抑制效果。 | |||
T80926 | Tuberculosis inhibitor 11 | ||
Tuberculosis inhibitor 11 (Compound 14) 是一种增强抗结核药物针对分枝杆菌活性的化学化合物。 | |||
T62086 | Tuberculosis inhibitor 5 | ||
Tuberculosis inhibitor 5 (Compound 11i) 是一种有效的抗结核剂,无明显细胞毒性。Tuberculosis inhibitor 5 是一种抗分枝杆菌 (antimycobacterial) 联苯类似物。 | |||
T62087 | Tuberculosis inhibitor 4 | ||
Tuberculosis inhibitor 4 (compound 16) 是基于扁桃酸的螺噻唑烷酮,表现出有效的抗分枝杆菌 (antimycobacterial) 作用。Tuberculosis inhibitor 4 的浓度低于 6.25 μg/mL 时,能够抑制 98% 的结核分枝杆菌菌株 H37Rv。 | |||
T80925 |
Tuberculosis inhibitor 12
|
||
Tuberculosis inhibitor 12(compound 12)作为恶二唑衍生物,表现出对结核分枝杆菌的显著抑制作用。在7H9-Tw-OADC介质中,Tuberculosis inhibitor 12(20 μM)展现了82%的抑制率,而在相同条件下抑制率为78%。 | |||
T79511 |
Tuberculosis inhibitor 8
|
||
Tuberculosis inhibitor 8 (compound 3b) 是 3-甲氧基-2-苯基咪唑并[1,2-b]哒嗪衍生物,具有针对结核分枝杆菌 (MIC90为 0.69 μM) 和海洋分枝杆菌 (MIC90为 0.69 μM) 的高抗菌活性。 | |||
T80927 | Tuberculosis inhibitor 10 | ||
Tuberculosis inhibitor 10 对 MSMEG_6649 的酶活性呈现中等抑制效果,并增强了 PAS 对分枝杆菌的抑制作用。 | |||
T79509 |
Tuberculosis inhibitor 6
|
||
Tuberculosis inhibitor 6 (compound 2c),作为3-甲氧基-2-苯基咪唑并[1,2-b]哒嗪衍生物,对结核分枝杆菌(MIC90≤1.66 μM)及海洋分枝杆菌(MIC90为2.65 μM)展示出显著的抑制活性。 | |||
T79512 |
Tuberculosis inhibitor 9
|
||
Tuberculosis inhibitor 9 (compound 3d) 为具有高抗菌性的3-甲氧基-2-苯基咪唑并[1,2-b]哒嗪衍生物,其针对结核分枝杆菌和海洋分枝杆菌的最小抑菌浓度(MIC90)均为0.64 μM。 | |||
T3583 |
Macozinone
PBTZ169 |
Antibacterial; DprE1 | Microbiology/Virology; Others |
Macozinone (PBTZ169) 是具有杀菌作用的苯并噻嗪酮,也有抗结核作用。它也是一种 DprE1有效抑制剂,可通过与活性位点 Cys387 残基形成共价键来抑制必需的黄素蛋白 DprE1。 | |||
T7342 |
BM212
|
Antibacterial | Microbiology/Virology |
BM212 是一种分枝杆菌膜蛋白 MmpL3抑制剂。它抑制结核分枝杆菌和部分非结核分枝杆菌,抗结核杆菌 H37Rv 菌株的 MIC 值为 5 µM。 | |||
T4044 |
DprE1-IN-2
|
Antibacterial; DprE1 | Microbiology/Virology; Others |
DprE1-IN-2 是 DprE1抑制剂,IC50为 28 nM,有抗结核作用。 | |||
T8411 |
C-215
|
Others | Others |
C-215 是MmpL3抑制剂。它在 HTS 中被鉴定为对结核分枝杆菌具有独立的甘油活性,对哺乳动物细胞的非特异性毒性较低,对结核分枝杆菌的IC90=16 μM,并且能够有效抑制在巨噬细胞中生长的结核分枝杆菌。 | |||
T10411 |
AU1235
|
Antibacterial | Microbiology/Virology |
AU1235是金刚烷脲,是一种MmpL3抑制剂。结核分枝杆菌蛋白MmpL3在细胞壁合成中起重要作用,它影响海藻糖单支霉菌酸酯跨内膜转运。 | |||
T8694 |
ML406
|
Antibacterial; Antibiotic | Microbiology/Virology |
ML406 是一种小分子探针,通过抑制M.tuberculosisBioA(DAPA 合酶) 显示出抗结核活性,IC50为 30 nM。 | |||
T5315 |
TCA1
TCA-1,TCA 1 |
Antibacterial; Antibiotic | Microbiology/Virology |
TCA1 (TCA 1) 是一种小分子,具有抗耐药性和持续性结核病的活性。 | |||
T0827 |
Cefsulodin sodium
Cefsulodine sodium,Sulcephalosporin,头孢磺啶钠 |
Antibacterial; Antibiotic | Microbiology/Virology |
Cefsulodin sodium (Sulcephalosporin) 是β内酰胺抗生素,对缘脓杆菌和肠杆菌有活性。 | |||
T3224 |
TBA-7371
AZ 7371,DprE1-IN-1 |
Antibacterial; PDE; DprE1 | Metabolism; Microbiology/Virology; Others |
TBA-7371 (DprE1-IN-1) 是一种非共价 DprE1有效抑制剂,具有强大的抗结核活性。 | |||
T7419 |
Sutezolid
PNU-100480,U-100480,PF-02341272 |
Antibacterial; Antibiotic | Microbiology/Virology |
Sutezolid (U-100480) 是一种具有口服活性恶唑烷酮抗菌剂,通过抑制细菌蛋白质合成发挥作用。它有抗分枝杆菌活性,可研究耐药结核病。 | |||
T22365 |
Methyl α-D-mannopyranoside
甲基-D-丙噻,Methyl α-D-mannopyranoside |
Antibacterial | Microbiology/Virology |
Methyl α-D-mannopyranoside (Methyl α-D-mannopyranoside) 是一种化学合成的中间体,在抗结核吸入治疗中靶向巨噬细胞。 | |||
T6425 |
BTZ043 Racemate
BTZ044,BTZ10526038,Benzothiazinone 10526038 |
Antibacterial; DprE1 | Microbiology/Virology; Others |
BTZ043 Racemate (Benzothiazinone 10526038) 是一种癸二烯基磷酰-β-D-核糖 2'-差向异构酶(DprE1) 抑制剂,用作新的抗分枝杆菌剂。 | |||
T0509 |
Cloxiquine
5-Chloro-8-quinolinol,氯羟喹,Dermofungin,Dermofongin,5-氯-8-羟基喹啉 |
Antibacterial; Antibiotic; PPAR; Parasite; Antifungal | DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Cloxiquine (Dermofongin) 具有抗菌,抗真菌和抗阿米巴虫的作用。它还可通过激活 PPARγ抑制黑素瘤细胞的生长和转移。它可研究结核病和皮肤病。 | |||
T16339 |
Norverapamil hydrochloride
(±)-Norverapamil hydrochloride,D591 hydrochloride,盐酸去甲维拉帕米 |
Calcium Channel; P-gp; Drug Metabolite | Membrane transporter/Ion channel; Metabolism; Neuroscience |
Norverapamil hydrochloride (D591 hydrochloride) 是 Verapamil 的 N-去甲基代谢物,是 L 型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。 | |||
T9995 |
Antituberculosis agent-5
|
Others | Others |
Antituberculosis agent-5是一种用于高通量测定的小分子。 | |||
T60879 |
Antituberculosis agent-2
|
||
Antituberculosis agent-2 (Compound 8d) 是一种针对耐多药结核病和药物敏感结核病均有效的抗结核剂。Antituberculosis agent-2 在小鼠和人类中显示出良好的微粒稳定性,具有低细胞毒性和可接受的口服生物利用度。Antituberculosis agent-2 具有抗结核活性。Antituberculosis agent-2 对结核分枝杆菌 H37Rv、13946 和 14862 的 MIC 值分别为0.454、1.757 和 1.644 μg/mL。 | |||
T72262 | Antituberculosis agent-6 | ||
Antituberculosis agent-6 是一种有效的抗结核分枝杆菌 (antimycobacterial) 剂。Antituberculosis agent-6 对M. tuberculosis 显示出显著的抑制活性,MIC 为 3.49 μM。Antituberculosis agent-6 还对A. niger 表现出良好的抗真菌 (antifungal) 活性,MIC 为 62.50 μM。 Antituberculosis agent-6 表现出高胃肠道吸收。 | |||
T61222 |
Antituberculosis agent-1
|
||
Antituberculosis agent-1 (Compound 8a) 是一种抗结核剂,对 M. tuberculosisH37Rv 的 MIC 值为 3.84 μg/mL。 | |||
T72263 |
Antituberculosis agent-8
|
||
Antituberculosis agent-8 是一种抗结核剂,对M. tuberculosis H37Rv 的 MIC 值为 3.53 μM (1.6 μg/mL)。Antituberculosis agent-8 对A. niger 也显示出良好的抗真菌 (antifungal) 活性,MIC 为 62.50 μM。 | |||
T63286 |
Antituberculosis agent-3
|
||
Antituberculosis agent-3 是一种具有抗霉菌作用的抗结核剂,对结核杆菌 H37Rv 株的生长具有抑制作用,其 MIC 值为 12.5 μg/mL。 | |||
T75019 | Antituberculosis agent-7 | ||
Antituberculosis agent-7 是一种氧杂环丁基喹啉衍生物,对P. mirabilis 具有良好的抗菌活性,MIC 为 31.25 μM。Antituberculosis agent-7 对A. niger 显示出良好的抗真菌活性,MIC 为 62.5 μM。Antituberculosis agent-7 显示出优异的抗分枝杆菌活性,对结核分枝杆菌 H37Rv 的 MIC 为 3.41 μM。 | |||
T74769 | Antituberculosis agent-9 | ||
Antituberculosis agent-9 (Compound 5a) 是一种具有口服活性的抗结核剂,对H37Ra 的MIC 为 0.5 μg/mL。 | |||
T5400 |
Q203
IAP6,Telacebec |
Antibacterial; Antibiotic | Microbiology/Virology |
Q203 (Telacebec)是一种中氮杂吡啶酰胺。 在培养基中抑制结核分枝杆菌H37Rv 活性的MIC50值为2.7 nM。 | |||
T7877 |
Thiacetazone
氨硫脲,Diazam,Thioacetazone,Neustab,Neotibil |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Thiacetazone (Diazam) 是一种氨基硫脲抗结核剂,也是一种具有口服活性抗生素。它具有抗菌作用,可抑制结核分枝杆菌 H37Rv 的生长,MIC 值为 0.1 μg/mL。 | |||
T4531 |
GSK2200150A
|
Antibacterial | Microbiology/Virology |
GSK2200150A 是一种通过高通量筛选活动确定的抗结核剂,对 H37Rv 的 MIC 是 0.38 μM。 | |||
T27482 |
GSK572A
|
Others | Others |
GSK572A 是一种新型且强效的EchA6强效抑制剂,可用来治疗肺结核。 | |||
T77730 |
QST4
|
Antifungal | Microbiology/Virology |
QST4 具有抗结核、抗真菌活性,在结核分枝杆菌 Mycobacterium tuberculosis H37Rv 中的 MIC 值为 6.25 μM。 | |||
T3642 |
TBA-354
TBA 354 |
Antibacterial; Antibiotic | Microbiology/Virology |
TBA-354 有抗结核作用,对结核分枝杆菌 H37Rv 菌株具有活性。 | |||
T9830 |
GSK2556286
GSK286 |
Antibacterial | Microbiology/Virology |
GSK2556286 (GSK286) 是一种具有口服活性的结核分枝杆菌 (M. tuberculosis) 抑制剂。GSK2556286 对人巨噬细胞 (macrophages) 生长具有抑制作用,IC50值为 0.07 μM。GSK2556286对多重耐药 (MDR) 或广泛耐药 (XDR) 和药物敏感 (DS) 结核分枝杆菌均有效。 | |||
T61411 |
InhA-IN-4
|
Antibacterial | Microbiology/Virology |
InhA-IN-4 (TU14) 是一种有效的结核分枝杆菌InhA(烯酰 ACP 还原酶) 抑制剂,具有潜在的抗癌和抗增殖活性,可用于研究结核分枝杆菌感染。 | |||
T11497 |
Ganfeborole HCl
GSK3036656 HCl,GSK656 HCl |
Antibacterial | Microbiology/Virology |
Ganfeborole HCl (GSK3036656 HCl) 是一种具有抗结核活性的小分子化合物,是结核分枝杆菌(Mtb)亮氨酰-tRNA 合成酶(LeuRS;IC50:0.2 μM)的抑制剂。 | |||
T5997 |
TBAJ-587
|
Antibacterial; Antibiotic | Microbiology/Virology |
TBAJ-587 是一种抗结核药物,在 MABA 和 LORA 试验中抑制 M.tb 菌株 H37Rv 的生长,MIC90 分别为 0.006 和 <0.02 µg/mL。它对 M. tuberculosis 具有更有效的活性,并且在 TB 动物模型中具有更好的功效。 | |||
T2585 |
Bedaquiline
R207910,TMC207,贝达喹啉 |
Antibacterial; Antibiotic | Microbiology/Virology |
Bedaquiline (R207910) 是一种二芳基喹啉药物,能同时靶向 c-亚基和 ε-亚基,抑制结核分枝杆菌 (Mtb) F1FO-ATP 合酶。它具有解偶联活性和有用于耐多药结核病的潜力。 | |||
T25817 |
Mitonafide
NSC-300288,米托萘胺,NSC300288,NSC 300288 |
Antibacterial | Microbiology/Virology |
Mitonafide (NSC-300288) 抑制 M. tuberculosis NAD+ 依赖性 DNA 连接酶 A 的活性。 它是一种 DNA 嵌入剂。 | |||
T27453 |
GSK1733953A
DG70 |
Antibacterial | Microbiology/Virology |
GSK1733953A 可作为一种小分子结核分枝杆菌呼吸抑制剂,对 MenG 活性有抑制作用,IC50 值为 2.6 ± 0.6 μM。GSK1733953A 是一种具有选择性的联苯苯甲酰胺,对结核分枝杆菌去甲基萘醌甲基转移酶的催化甲基化有抑制作用,对结核分枝杆菌H4Rv的MIC为8.37 μg/ml,对耐药菌株的MIC为1.2至9.6 μg/ml。GSK1733953A 是治疗结核病的候选化合物。 | |||
T6096 |
Pretomanid
(S)-PA 824,PA-824 |
Antibacterial; Antibiotic | Microbiology/Virology |
Pretomanid ((S)-PA 824) 是一种抗生素,可研究肺部多重耐药性结核病。它对结核病(MTB) 具有亚微摩尔作用活性。它对 MTB 泛敏感和抗 Rifampin 的临床分离株的 MIC 值为 0.015 至 0.25 μg/mL。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1426 |
Pyrazinamide
Pyrazinoic acid amide,Pyrazinecarboxamide,吡嗪酰胺 |
Antibacterial; Antibiotic; Autophagy; Fatty Acid Synthase | Autophagy; Metabolism; Microbiology/Virology |
Pyrazinamide (Pyrazinecarboxamide) 是一种口服抗结核类抗生素。它是一种前药,通过结核分枝杆菌pncA 基因编码的 PZase/烟酰胺酶转化为活性吡嗪酸形式。 | |||
T8347 |
Rifamycin S
|
Reactive Oxygen Species; ROS; Antibacterial; Antibiotic | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Rifamycin S 是一种 DNA 依赖性 RNA 聚合酶抑制剂,是一种醌和一种针对革兰氏阳性细菌的抗生素试剂。它是涉及两个电子的可逆氧化还原系统的氧化形式。它能产生活性氧并抑制微粒体脂质过氧化,可研究肺结核和麻风病。 | |||
T3332 |
Isosteviol
异甜菊醇,(-)-Isosteviol |
IL Receptor; Potassium Channel; TNF; NF-κB; Reactive Oxygen Species; COX; Topoisomerase | Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB |
Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂,属于四环二萜糖苷,是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶,具有抗菌、抗癌和抗结核作用。 | |||
T1589 |
D-Cycloserine
RO-1-9213,D-环丝氨酸 |
Others; Antibacterial; Antibiotic; iGluR | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others |
D-Cycloserine (RO-1-9213) 是一种抗生素,靶向细菌细胞壁肽聚糖生物合成酶。它是一种NMDA 部分激动剂,可以改善认知功能,可研究耐多药结核病。 | |||
T0793 |
Kanamycin sulfate
硫酸卡那霉素,Kanamycin monosulfate,Kanamycin A monosulfate,Ophtalmokalixan |
ribosome; Antibacterial; Antibiotic | Microbiology/Virology |
Kanamycin sulfate (Kanamycin monosulfate) 是氨基糖苷类杀菌抗生素,它通过与细菌30S 核糖体结合起作用。 | |||
TN1466 |
Canthin-6-one
NSC 103003 |
Antifungal | Microbiology/Virology |
Canthin-6-one(NSC 103003) 是一种从 Allium neapolitanum 分离出来的生物碱,具有抗菌活性,对结核分枝杆菌具有抑制作用。 | |||
TN2279 |
Totarol
(+)-Totarol,桃柁酚 |
Antibacterial; Antifection | Microbiology/Virology |
Totarol ((+)-Totarol) 对几种致病性革兰氏阳性细菌、结核分枝杆菌具有抗菌作用。 | |||
TN5503 |
Linaroside
|
Antibacterial | Microbiology/Virology |
Linaroside 在 6.25 microg mL(-1) 浓度下对结核分枝杆菌、菌株 H(37)Rv 的抗分枝杆菌活性表现出 30%的抑制作用。 | |||
T8298 |
Vasicine hydrochloride
鸭嘴花碱盐酸盐,Peganine hydrochloride |
Antibacterial; Antibiotic | Microbiology/Virology |
Vasicine hydrochloride (Peganine hydrochloride) 是从Justicia adhatoda 中分离得到的一种喹唑啉类生物碱,有抗结核活性。 | |||
T5041 |
Faropenem sodium
法罗培南,法罗培南钠 |
Antibacterial; Antibiotic | Microbiology/Virology |
Faropenem sodium 是一种口服生物可利用的青霉烯类抗生素,能有效杀灭结核分枝杆菌,治疗结核病和社区获得性肺炎。 | |||
T67136 |
1-Hydroxy-2-butanone
|
Endogenous Metabolite; Antibiotic | Metabolism; Microbiology/Virology |
1-Hydroxy-2-butanone 是可从竹子汁和番茄叶中提取得到的天然产物,具有抗结核活性。 | |||
TQ0184 |
Chebulinic acid
|
ATPase; Proton pump; DNA/RNA Synthesis; Antibacterial; TGF-beta/Smad | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Stem Cells |
Chebulinic acid 是从诃子果中提取的一种天然产物,结核分枝杆菌 DNA 促旋酶的有效抑制剂。它也能抑制 SMAD-3 phosphorylation 和 H+ K+-ATPase 的活性。 | |||
T5722 |
Nevadensin
Pedunculin,石吊兰素,5,7-二羟基-6,8,4'-三甲氧基黄酮 |
Anti-infection; Antibacterial | Microbiology/Virology |
Nevadensin 是一种重要的草本成分,可抑制雌二醇的生物活化。 它具有抗结核分枝杆菌、镇咳、抗炎、抗高血压等多种药理作用。 | |||
T4964 |
steviolbioside
CCRIS-6025,菊双糖甙,甜菊双糖苷 |
Others | Others |
Steviolbioside (CCRIS-6025) 是一种存在于甜菊叶中的罕见甜味剂。它对几种人类癌细胞有抑制作用,对乳腺癌具有潜在的研究价值。 | |||
T1165 |
Ethionamide
Bayer 5312,乙硫异烟胺,2-ethylthioisonicotinamide,Ethinamide |
Dehydrogenase; CAT; Antibacterial; Antibiotic | Metabolism; Microbiology/Virology; oxidation-reduction |
Ethionamide (2-ethylthioisonicotinamide) 是一种抗结核抗生素。 | |||
TN2086 |
Piperlotine A
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Antibacterial | Microbiology/Virology |
Piperlotine A 是一种可从罗洛胡椒中提取得到的生物碱,具有抗血小板聚集活性。Piperlotine A 在体外试验中显示出对结核分枝杆菌的抑制作用,MIC 值为 50 ug/mL。 | |||
TN1019 |
Beta-mangostin
β-Mangostin,beta-倒捻子素 |
Apoptosis; Antibacterial; Parasite | Apoptosis; Microbiology/Virology |
Beta-mangostin (β-Mangostin) 是存在 Cratoxylum arborescens 中的一种氧杂蒽酮类天然产物,有抗癌和抗菌活性,对结核分枝杆菌的 MIC 值为 6.25 μg/mL。它在体外有抗疟活性,对恶性疟原虫的 IC50值为 3.00 μg/mL。 | |||
TN1622 |
Ermanin
堪非醇3,4'-二-O-甲醚 |
NOS; Influenza Virus; COX; HIV Protease; Antibacterial; Antibiotic | Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ermanin 是一种从 Tanacetum microphyllum 中分离出来的类黄酮。Ermanin抑制血小板聚集,具有抗结核和抗病毒/细菌特性。Ermanin 可抑制 iNOS 和 COX-2 的表达,从而具有抗炎活性。Ermanin 可能具有抗 HIV-1 活性。Ermanin 在较低浓度下可有效地抑制 Dione juno 幼虫。 | |||
T3S1612 |
kuwanon G
桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G |
Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase | GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂,具有杀菌作用。 | |||
TN5614 |
Dehydrobruceantin
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Dehydrobruceantin has anti-tuberculosis activity. | |||
TN3674 |
Clauszoline M
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Antifection | Microbiology/Virology |
Clauszoline M shows a significant anti-tuberculosis activity. | |||
TN5657 | Goniotriol | ||
Goniotriol shows antimycobacterial activity against Mycobacterium tuberculosis (MIC =100 microg/mL). It exhibits antiplasmodial activity against Plasmodium falciparum (IC50=2.6 microg/mL). Goniotriol shows cytotoxicity against cancer cells, KB, BC1, NCI-H | |||
TN1378 |
α-Viniferin
ALPHA-VINIFERIN,Alpha-葡萄素 |
P450; NO Synthase; Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism |
α-Viniferin 也称为2-芳基苯并呋喃类黄酮,是前列腺素H2合成酶抑制剂。具有抗阿尔茨海默病、抗结核、抗肿瘤、抗炎、抗糖尿病等多种药理活性 | |||
TN5648 | Porson | ||
Porson exhibited anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro and MICs values of 40.0 μg/mL. | |||
TN3422 |
Anisofolin A
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Antifection | Microbiology/Virology |
Anisofolin A has promising antimalarial activity (IC50 4.39 ± 0.25 uM). It has promising antimycobacterium activity [IC50 4.50 ± 0.75 uM (3.31 ug/mL)] against M. tuberculosis H37Ra and at 100 ug/mL, shows 55.6 % inhibition of M. bovis. | |||
TN5684 |
5,6-Desmethylenedioxy-5-methoxyaglalactone
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5,6-Desmethylenedioxy-5-methoxyaglalactone is cytotoxic to small cell lung cancer (NCI-H187) cell line. It has antimycobacterial activity against Mycobacterium tuberculosis H(37)Ra. | |||
TN4944 | Santamarine | Caspase | Apoptosis; Proteases/Proteasome |
Santamarine has significant anticancer activity, can inhibit L1210 cells because of its cytotoxic,cytostatic and blocking mitosis and reducing uptake of thymidine. Santamarine and reynosin show bactericidal activity against clinical strains of Mycobacterium tuberculosis. | |||
T75564 | Pomolic acid 3-acetate | ||
Pomolic acid 3-acetate 是一种抗结核 (antitubercular) 剂,对 Mycobacterium tuberculosisH37Rv 的 MIC 为 32 μM。 | |||
TN4336 | Isothymusin | Antifection | Microbiology/Virology |
Isothymusin( MIC= 200 microg/mL) exhibits inhibition activity against Mycobacterium tuberculosis. It ( IC50=7.7 microg/mL ) exhibits antioxidant activity against the radical scavenging ability of DPPH. | |||
T69368 |
GKK1032B
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GKK1032B is a fungal metabolite that has antiproliferative and antibacterial activities. GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells and Vero cells. It also inhibits the growth of B. subtilis and M. tuberculosis. | |||
TN3924 | Eichlerialactone | Others | Others |
Eichlerialactone and ethyl eichlerianoate show antimycobacterial activity against mycobacterium tuberculosis H37Ra, with minimum inhibitory concentration in the range of 25-50ug/mL; eichlerialactone exhibits good antibacterial activity against both the Gr | |||
TN4953 |
Sativan
三叶草 |
Antifection | Microbiology/Virology |
Sativan possesses a broad spectrum of antimicrobial activity against bacteria and phytopathogenic fungi, it exhibits antituberculosis activity against Mycobacterium tuberculosis H37Rv, with the MIC value of 50 ug/mL. | |||
T38019 |
Nybomycin
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Nybomycin is a fungal metabolite originally isolated from Streptomyces sp. A717 and has antibacterial activity. It is active against B. subtilis, B. cereus, B. mycoides, M. smegmatis, and K. pneumoniae (MICs = 0.025, 2, 0.8, 0.2, and 0.003 μg/ml, respectively). Nybomycin is also active against M. tuberculosis and M. bovis (MICs = 4.5 and 1 μg/ml, respectively). | |||
TN3560 |
Cabralealactone
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Antifection | Microbiology/Virology |
Cabralealactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line, it is moderately active against a small-cell lung cancer (NCI-H187) cell line. | |||
TN3559 |
Cabraleahydroxylactone
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HSV | Microbiology/Virology |
Cabraleahydroxylactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line.It shows antiviral activity against herpes simplex virus type-1 with an IC50 value of 3.20 ug/mL, in comparison with the standard acyclovir (IC50=1.90ug/mL). | |||
TN5404 |
(+)-Conocarpan
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Conocarpan has antinociceptive effects. Conocarpan is quite active against S. aureus and B. subtilis with MIC of 6.25 micrograms/ml, it also shows activity against M. tuberculosis (MIC=15.6 ug/ml). Conocarpan shows considerable activity against epimastigo | |||
T75631 | Ganorbiformin B | ||
Ganorbiformin B是一种具有与灵芝酸相同羊毛甾烷骨架的羊毛甾烷三萜类化合物。其C-3差向异构体灵芝酸T对结核分枝杆菌H37Ra显示出强抗分枝杆菌活性。 | |||
TN4776 | Physalin D | TNF; Antifection | Apoptosis; Microbiology/Virology |
Physalin D shows antimalarial activity; it also exhibits a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 microg/mL. Physalin D displays considerable cytotoxicity against several cancer cell lines. It | |||
TN3557 |
Cabraleadiol
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ATPase; Antifection | Membrane transporter/Ion channel; Microbiology/Virology |
Cabraleadiol displays antimycobacterial activity against Mycobacterium tuberculosis, it also is weakly cytotoxic to a breast cancer (BC) cell line. Cabraleadiol inhibits photosystem II (PS II) and induces the appearance of small G band which is related wi | |||
T75676 | Orotidine 5′-monophosphate trisodium | ||
Orotidine 5'-monophosphate trisodium 是一种嘧啶核苷酸。Orotidine 5'-monophosphate trisodium 是通过从头合成途径合成的,用于在大量微生物中合成 DNA,包括 M. tuberculosis、S. cerevisiae、S. typhimurium 和 P. falciparum 等等。乳清酸磷酸核糖基转移酶 (OPRT) 以磷酸核糖焦磷酸 (PRPP) 和乳清酸 (OA) 作为底物催化合成 Orotidine 5'-monophosphate trisodium[1] | |||
T36815 | Chevalone C | ||
Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). Chevalone C inhibits the growth of multidrug-resistant isolates of E. coli, S. aureus, and E. faecium in a disc diffusion assay when used at a concentration of 15 μg/disc. It also induces cell death in HCT116 colorectal carcinoma cells. | |||
T75633 | (22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid | ||
(22S,24E)-3β,22-Diacetoxylanosta-7,9(11),24-trien-26-oic acid (compound 15) 为具有抗结核活性的化合物,对结核分枝杆H37Ra的最小抑菌浓度(MIC)为12.5 μg/mL,并展现出对Vero细胞的细胞毒性,其半数抑制浓度(IC50)值为32 μM[1]。 | |||
TN4840 |
Psoromic acid
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Others | Others |
Psoromic acid is a selective and covalent rab-prenylation inhibitor targeting autoinhibited RabGGTase, it shows antibacterial activities against Streptococcus gordonii and Porphyromonas gingivalis, and it is an effective and safe natural drug plausible fo | |||
TN5014 | Shoreic acid | Antifection; HSV | Microbiology/Virology |
Shoreic acid exhibits antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis with activity indices (AI) of 0.2, 0.3, 0.5 and 0.4, respectively, it also shows antifungal activity against C. albicans and T. mentagrophytes with AI | |||
T72742 |
(-)-Pinocembrin
(-)-乔松素 |
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(-)-Pinocembrin 对 H37Ra 结核分枝杆菌展示了抗菌活性,无论是休眠还是活跃期,其 IC50 值分别为1.11 mg/mL 和 1.21 mg/mL。作为一种抗增殖剂,(-)-Pinocembrin 对于 THP-1、A549、Panc-1、HeLa 和 MCF7 细胞系,IC50 值范围为 1.88 至 11.00 mg/mL。 | |||
T38330 |
Collinin
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Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a... | |||
TN1694 |
Gliotoxin
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Apoptosis; NF-κB; Wnt/beta-catenin; COX; PKA; Antibacterial; Antifection | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors |
Gliotoxin 是一种次生代谢产物,由A. fumigatus 分泌,可以抑制巨噬细胞的吞噬作用和其他免疫细胞的免疫功能。它通过阻止 IκB 降解来抑制诱导型NF-κB 活性,从而诱导宿主细胞凋亡。它可以激活PKA 并增加细胞内 cAMP 浓度,调节肌动蛋白细胞骨架重排以促进A. fumigatus 内化到肺上皮细胞。 |