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103

抑制剂 & 化合物

39

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T15486	HLM006474	Others	Others
	HLM006474 是光谱的E2F 抑制剂，在 A375 细胞中，可抑制 E2F4 DAN 结合(IC50:29.8 µM)。
T16465	Penicillin G benzathine Benzathine benzylpenicillin,Benzathine penicilline G	Antibacterial	Microbiology/Virology
	Penicillin G benzathine 具有抗细菌感染活性，可用于研究早期梅毒。
T5560	Dicyclanil	Others	Others
	Dicyclanil 是一种化学结构与环丙嗪相似的昆虫生长调节剂。
T13673	EGTA-AM EGTA Acetoxymethyl ester	Others	Others
	EGTA-AM (EGTA Acetoxymethyl ester) 是一种钙离子螯合剂，是一种膜渗透形式的 EGTA，是早发型子痫前期和晚发性子痫前期的代谢生物学标志物。
T9109	SSAA09E2	RAAS; SARS-CoV	Endocrinology/Hormones; Microbiology/Virology
	SSAA09E2 是一种新型的SARS-CoV 复制抑制剂，通过阻断SARS-S 与SARS-CoV 受体血管紧张素转换酶-2 的早期相互作用发挥作用。
T77162	Donanemab
	Donanemab (LY3002813)为针对N末端焦谷氨酸β淀粉样蛋白(Aβ)表位的人源化IgG1单克隆抗体, 具潜力于早期阿尔茨海默病研究。
T12321	ORM-10103	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	ORM-10103 是一种新型有效且具有选择性的 Na+/Ca2+ 交换体 (NCX) 抑制剂。ORM-10103 对 NCX 电流有抑制作用，在 -80 和 20 mV 下的 IC50 的估算值分别为 55 和 67 nM，可减少犬心脏的早期和延迟后去极化。
T9925	Ofatumumab	Others	Others
	Ofatumumab 是一种人源化靶向抗 CD20单克隆抗体。它作用于表达 CD20 的 B 淋巴细胞，能够诱导产生抗体依赖性细胞介导的细胞毒性和补体依赖性细胞毒性的作用。
T35258	YM 16638 YM 638,YM-16638,YM16638	LTR	Immunology/Inflammation
	YM 16638 是一种具有口服活性的白三烯（LT）拮抗剂，具有降低甘油三酯和增加过氧化物酶体的作用，可用于研究抗原诱导过敏性绵羊早期和晚期气道反应。
T3131	Fosfomycin calcium Phosphomycin calcium salt,Fosmicin,磷霉素钙	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin calcium (Phosphomycin calcium salt) 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药细菌。
T3628	Madrasin DDD00107587	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Madrasin (DDD00107587) 是剪接抑制剂，在体外能够阻止剪接中间体和产物的形成，并干扰剪接体组装途径中的一个或多个早期步骤。它能在体外抑制 pre-mRNA 的剪接，并修饰细胞中内源性 pre-mRNA 的剪接。
T30249	AZD 7009 AZD-7009,AZD7009	Sodium Channel	Membrane transporter/Ion channel
	AZD 7009是一种新型抗心律失常化合物，对CHO K1细胞中 hNav1.5的钠电流具有抑制作用，IC50为11 uM。AZD 7009 对离体兔心房和心室肌细胞的晚期钠电流具有抑制作用，对e -4031诱导的动作电位持续时间延长具有抑制作用，促使浦肯野纤维的早期后去极化(EADs)。
T63788	PCLX-001	Others	Others
	PCLX-001 is a small-molecule compound that acts as an orally active inhibitor of N-myristoyltransferase (NMT), specifically targeting NMT1 and NMT2 with IC50 values of 5 nM and 8 nM, respectively. This compound demonstrates anti-tumor effects and effectively inhibits the early signaling of B-cell receptor (BCR). Consequently, PCLX-001 is a valuable tool for researching B-cell malignancies [1] [2].
T8903	Retro-2 Retro 2,2-{[(5-methyl-2-thienyl)methylene]amino}	Others; Virus Protease; Parasite; Autophagy	Autophagy; Microbiology/Virology; Others
	Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) 是一种植物毒素蓖麻毒素抑制剂，它保护 HeLa 细胞免受蓖麻毒素、Stx1 和 Stx2 的侵害，选择性地阻断早期内体蛋白质-高尔基体界面处的逆行毒素运输。
T21327	Uridine triacetate RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate	Others	Others
	Uridine triacetate (RG 2133 triacetate) 是一种具有口服活性的 Uridine 前药。Uridine triacetate 能在肠道内迅速被吸收，在循环中迅速脱乙酰，生成游离尿苷。Uridine triacetate 可用于研究 5-氟尿嘧啶 (5-FU) 和卡培他滨的毒性，或早发性心脏或中枢神经系统 (CNS) 毒性。
T36466	Chlorin E6 Ce6,Chlorin e6,CE6	Parasite	Microbiology/Virology
	Chlorin E6 (CE6) 是一种第二代光敏剂，在与辐照结合使用时具有抗肿瘤活性。在植入性纤维肉瘤的小鼠模型中，Chlorin E6（2.5-10 毫克/千克，静脉注射，50-200 焦耳/平方厘米的辐照）在不同程度的辐照后会导致肿瘤完全消失。在一项针对支气管源性早期浅表鳞状细胞癌患者的 I 期临床研究中，对包括 Chlorin E6 在内的制剂进行了测试，结果良好（40 毫克/平方米，静脉注射，100 焦耳/平方厘米的激光辐照）。在一项针对早期肺癌患者的二期临床试验中，同样的给药模式使 82.9% 的患者获得了完全应答。Chlorin E6 已被研究为一种纳米技术给药工具。
T16500	PF-3450074 PF-74	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	PF-3450074 (PF-74)是 HIV-1 衣壳蛋白的特异性抑制剂，可广谱抑制 HIV 分离株。它在 HIV-1 感染的早期阶段起作用，通过与 CPSF6 和 NUP153 的结合直接竞争来抑制病毒复制，并阻断病毒生命周期的脱膜，组装和逆转录步骤。
T26873	BMY-27709 BMY 27709,BMY27709	Influenza Virus	Microbiology/Virology
	BMY-27709 是一种流感病毒生长抑制剂，对 A/WSN/33 病毒生长的 IC50 值为 3-8 μM，对流感病毒的部分亚型也展现出抑制活性。BMY-27709 对 H1 和 H2 病毒感染的早期起作用，通过抑制血凝素蛋白展现其抗病毒活性。然而，BMY-27709 对 H3 亚型病毒以及 B 型/Lee/40 流感病毒没有作用。
T77697	BML-278 BML278,BML 278	Sirtuin; Histone Methyltransferase	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BML-278 是一种 SIRT1 激活剂，EC150 值为 1 μM。BML-278 增加父本和母本原核中的 H3K9 甲基化并抑制 H3K9 乙酰化，可用于改善早期胚胎发育。BML-278 促使原代人间充质细胞的细胞周期停止在 G1/S 期，可用于延缓衰老。BML-278 减少 U937 细胞中的微管蛋白乙酰化，增加小鼠 C2C12 成肌细胞的线粒体密度。
T27333	FLI-28 FLI28
	FLI-28 is a novel general secretion inhibitor in early stage.
T32014	GTC365 GTC 365,NSC 177365,GTC-365,NSC-177365,NSC177365
	GTC365 is an hTERT transcriptional repressor that acts in the early stages of the G-quadruplex folding pathway.
T61421	LUF7244
	LUF7244, a selective allosteric modulator of K v 11.1 channels, effectively suppresses early afterdepolarizations and holds potential for anti-arrhythmia research [1].
T32684	Leuprolide (1-3) Leuprorelin
	Leuprolide (1-3) is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty.
T68834	Lortalamine
	Lortalamine is an antidepressant which was synthesized in the early 1980s. It acts as a potent and highly selective norepinephrine reuptake inhibitor.
T69613	Ar-H047108 free base
	Ar-H047108 free base is an imidazopyridine potassium competitive acid blocker (P-CAB). This drug may be used to treat early stellate cell activation and veno-occlusive-disease (VOD)-like hepatotoxicity.
T20676	Anilofos 莎稗磷,Rico,Arozin
	Anilofos, a widely used thionoorganophosphate herbicide, is used for pre-emergence and early post-emergence control annual sedges and grass weeds in transplanted rice crops.
T41135	Defensin HNP-1 human
	Defensin HNP-1 human is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development.Defensin HNP-1 human can regulate the growth of atherosclerosis.
T70577	PEN-866
	PEN-866 is a potential agent for controlling early stage tumor growth for non-small cell lung cancer (NSCLC). PEN-866 is a novel esterase-cleavable conjugate of an HSP90i and a topoisomerase I inhibitor, SN-38
T34903	TO-PRO3 iodide TOPRO3 iodide,TO-PRO3 iodide salt
	TO-PRO3 iodide is a nucleic acid stain that can stain the nucleus of cells in different states, including living, early apoptotic, and necrotic cells.
T69788	Daledalin
	Daledalin is an antidepressant which was synthesized and trialed for depression in the early 1970s, but was never marketed. It is a selective norepinephrine reuptake inhibitor, with no significant effects on the reuptake of serotonin and dopamine, and no antihistamine or anticholinergic properties.
T28782	Sinoporphyrin sodium sinoporphyrin,DVDMS Free,DVDMS
	Sinoporphyrin sodium significantly suppressed cell proliferation, promoted early apoptotic response, triggered collapse of F-actin filaments and inhibited cell migration. Sinoporphyrin sodium potentially a treatment for cancer. Sinoporphyrin sodium is als
T10408	ATWLPPR Peptide TFA	Others	Others
	ATWLPPR Peptide TFA is a selective neuropilin-1 inhibitor and inhibits VEGF165 binding to NRP-1. It has the potential in reducing the early retinal damage caused by diabetes.
TP2296	TLQP-21	Others	Others
	TLQP 21 is a VGF-derived peptide. TLQP 21 can protect cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis and increases energy expenditure and prevents early phase diet-induced diabetes.
T71808	Tisopurine
	Tisopurine is a drug used in the treatment of gout in some countries. It reduces uric acid production through inhibiting an early stage in its production.
T37327	Prostaglandin F2α 1,15-lactone Prostaglandin F2α 1,15-lactone
	PGF2α 1,15-lactone is a lipid-soluble internal ester of PGF2α. Hydrolysis of the lactone readily produces free PGF2α in plasma. In rhesus monkeys, a total dose of 15 mg of PGF2α 1,15-lactone terminates early pregnancy, whereas PGF2α is ineffective.
T9763	MMV666810
	MMV666810 是一种类似于 MMV390048 的2-氨基吡嗪，5.94 nM 的 MMV666810 对无性寄生虫有效。与早期相比，MMV666810 对晚期配子体细胞的选择性是早期的3.3倍（早期配子体:IC50603 ± 88 nM; 晚期配子体:IC50179 ± 8 nM）。
T39256	MMV674850 MMV674850
	MMV674850 exhibits potency against asexual stage parasites, with IC50 values of 2.7 and 4.5 nM. Furthermore, it demonstrates a preferential affinity for early-stage gametocytes, displaying an IC50 value of 4.5 ± 3.6 nM, compared to late-stage gametocytes with an IC50 value of 28.7 ± 0.2 nM.
T82005	JNJ-8003	RSV	Microbiology/Virology
	JNJ-8003 为 RSVPolymerase 高效抑制剂，能在 RNA 转录与复制初期阶段抑制核苷酸的聚合作用。
T31671	Erythrityl Tetranitrate Eritrityli tetranitras,Tetranitrato de eritritilo,CHEBI:60072,Tetranitrate d'eritrityle
	Erythrityl Tetranitrate is a vasodilator with general properties similar to nitroglycerin. Like many nitrate esters, ETN acts as a vasodilator, and was the active ingredient in the original "sustained release" tablets, made in the early 50s. Ingesting ETN or prolonged skin contact can lead to absorption and what is known as a "nitro headache".
T22685	CP-471474 CP 471474	Others	Others
	Broad spectrum MMP inhibitor (IC<sub>50</sub> values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice.
T39068	Fomivirsen sodium
	Fomivirsen sodium is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen sodium binds to and degrades the mRNAs encoding CMV immediate-early 2 protein (required for viral replication), thus providing bioactive effects for CMV retinitis by inhibition of virus proliferation.
T83836	3'-O-Methylguanosine-5'-O-triphosphate sodium 3'-O-methyl GTP
	3'-O-Methylguanosine-5'-O-triphosphate（3'-O-methyl GTP）是GTP的甲基化衍生物，用作早期RNA聚合酶II延伸中间体制备中的链终止试剂。
T60386	LCS-1
	LCS-1, a superoxide dismutase 1 (SOD1) inhibitor, effectively inhibits the enzymatic activity of SOD1 with an IC50 value of 1.07 μM. Additionally, LCS-1 triggers both early and late-stage apoptosis in multiple myeloma (MM.1S) cells [1] [2] [3].
T21951	CDP 840 hydrochloride
	CDP-840 (GR259653X) 是一种有效的、选择性和口服活性的phosphodiesterase IV (PDE IV)抑制剂。CDP-840 抑制有意识的松鼠猴中抗原诱导的早期和晚期支气管收缩。
T1769	Pardoprunox 帕多芦诺,SLV-308,DU-126891	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Pardoprunox (SLV-308) 是多巴胺受体D2、D3部分激动剂和5-HT1A 激动剂，pEC50分别为 8、9.2 和 6.3。
T68588	CP-10447
	CP-10447 is an inhibitor apolipoprotein B (apoB) and triglyceride secretion in human hepatoma cells (HepG2) by inhibiting MTP activity and stimulating the early ER degradation of apoB. It is useful tool for further study of the mechanisms of apoB secretion and triglyceride-rich lipoprotein assembly.
T70800	Elenbecestat free base
	Elenbecestat,also known as E2609 is a BACE1 inhibitor. By inhibiting BACE, a key enzyme in the production of Aβ peptides, E2609 decreases the formation of these peptides which can aggregate into toxic oligomers and protofibrils and eventually form amyloid plaques in the brain. Elenbecestat has been shown to reduce Aβ levels in cerebrospinal fluid, was investigated in two global phase 3 studies in early AD.
T28933	TCV-309 TCV309
	TCV-309 is an inhibitor of platelet activating factor (PAF). TCV-309 reduces graft PMN infiltration and enhances early function of 24-hour-preserved rat kidneys with long warm ischemia. TCV-309 attenuates the priming effects of bronchoalveolar macrophages
T73749	Fomivirsen
	Fomivirsen (ISIS-2922 free base)为一种21 mer磷酸硫寡核苷酸反义药物。作为抗巨细胞病毒视网膜炎(CMV)研究的重要试剂，通过结合并降解CMV immediate-early 2蛋白的mRNA，Fomivirsen有效抑制病毒复制。
T82006	JM3A
	JM3A为高特异性生物活性肽，针对早期肺癌细胞转化过程中新表达的细胞表面波形蛋白(CSV)。通过与荧光团耦合，JM3A能够检测并标记CSV。

化合物

Cat.No: T15486

Target: Others

Penicillin G benzathine

Cat.No: T16465

Synonym: Benzathine benzylpenicillin,Benzathine penicilline G

Target: Antibacterial

Cat.No: T5560

Target: Others

Cat.No: T13673

Synonym: EGTA Acetoxymethyl ester

Target: Others

Cat.No: T9109

Target: RAAS, SARS-CoV

Cat.No: T77162

Cat.No: T12321

Target: Calcium Channel

Cat.No: T9925

Target: Others

Cat.No: T35258

Synonym: YM 638,YM-16638,YM16638

Target: LTR

Fosfomycin calcium

Cat.No: T3131

Synonym: Phosphomycin calcium salt,Fosmicin,磷霉素钙

Target: Antibacterial, Antibiotic

Cat.No: T3628

Synonym: DDD00107587

Target: DNA/RNA Synthesis

Cat.No: T30249

Synonym: AZD-7009,AZD7009

Target: Sodium Channel

Cat.No: T63788

Target: Others

Cat.No: T8903

Synonym: Retro 2,2-{[(5-methyl-2-thienyl)methylene]amino}

Target: Others, Virus Protease, Parasite, Autophagy

Uridine triacetate

Cat.No: T21327

Synonym: RG 2133 triacetate,PN-401,Tri-O-acetyluridine,PN401,RG 2133,RG-2133,PN 401,RG2133,RG2133 triacetate

Target: Others

Cat.No: T36466

Synonym: Ce6,Chlorin e6,CE6

Target: Parasite

Cat.No: T16500

Synonym: PF-74

Target: HIV Protease

Cat.No: T26873

Synonym: BMY 27709,BMY27709

Target: Influenza Virus

Cat.No: T77697

Synonym: BML278,BML 278

Target: Sirtuin, Histone Methyltransferase

Cat.No: T27333

Synonym: FLI28

Cat.No: T32014

Synonym: GTC 365,NSC 177365,GTC-365,NSC-177365,NSC177365

Cat.No: T61421

Leuprolide (1-3)

Cat.No: T32684

Synonym: Leuprorelin

Cat.No: T68834

Ar-H047108 free base

Cat.No: T69613

Cat.No: T20676

Synonym: 莎稗磷,Rico,Arozin

Defensin HNP-1 human

Cat.No: T41135

Cat.No: T70577

Cat.No: T34903

Synonym: TOPRO3 iodide,TO-PRO3 iodide salt

Cat.No: T69788

Sinoporphyrin sodium

Cat.No: T28782

Synonym: sinoporphyrin,DVDMS Free,DVDMS

ATWLPPR Peptide TFA

Cat.No: T10408

Target: Others

Cat.No: TP2296

Target: Others

Cat.No: T71808

Prostaglandin F2α 1,15-lactone

Cat.No: T37327

Synonym: Prostaglandin F2α 1,15-lactone

Cat.No: T9763

Cat.No: T39256

Synonym: MMV674850

Cat.No: T82005

Target: RSV

Erythrityl Tetranitrate

Cat.No: T31671

Synonym: Eritrityli tetranitras,Tetranitrato de eritritilo,CHEBI:60072,Tetranitrate d'eritrityle

Cat.No: T22685

Synonym: CP 471474

Target: Others

Fomivirsen sodium

Cat.No: T39068

3'-O-Methylguanosine-5'-O-triphosphate sodium

Cat.No: T83836

Synonym: 3'-O-methyl GTP

Cat.No: T60386

CDP 840 hydrochloride

Cat.No: T21951

Cat.No: T1769

Synonym: 帕多芦诺,SLV-308,DU-126891

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Cat.No: T68588

Elenbecestat free base

Cat.No: T70800

Cat.No: T28933

Synonym: TCV309

Cat.No: T73749

Cat.No: T82006

Cat. No.	Product Name	Target	Signaling Pathways
TN1025	3,29-O-Dibenzoyloxykarounidiol	Others	Others
	3,29-O-Dibenzoyloxykarounidiol 是一种苯甲酸三萜烯酯，从 Momordica grosvenori 果实中提取。它能够抑制肿瘤启动子 TPA 诱导的 EB 病毒早期抗原活化。
T5785	MALTOTETRAOSE Fujioligo 450,Amylotetraose,α-1,4-Tetraglucose,麦芽四糖	TNF; Endogenous Metabolite	Apoptosis; Metabolism
	Maltotetraose (Fujioligo 450) 能够作为生物流体中酶联测定淀粉酶特性的底物。
T0613	3-Hydroxyisovaleric acid β-羟基异戊酸,Beta-Hydroxyisovaleric acid	Others; Endogenous Metabolite	Metabolism; Others
	3-Hydroxyisovaleric acid (Beta-Hydroxyisovaleric acid) 是尿液中排泄的内源性代谢产物，可作为生物素缺乏的早期和敏感指标。
T19564	Stearoylcarnitine Stearoyl-L-carnitine	Endogenous Metabolite	Metabolism
	Stearoylcarnitine (Stearoyl-L-carnitine) 是一种脂肪酯脂质分子，是一种人内源代谢产物，可作为早发型子痫前期和晚发性子痫前期的生物标志物。
TN1031	Poricoic acid B 茯苓酸B,茯苓新酸 B	Others	Others
	Poricoic acid B 是提取自 Poria cocos 中，拥有抗肿瘤作用。
TN2121	3,5,7,3′,4′-Pentamethoxyflavone 栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether	Others	Others
	3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) 是一种分离自小花山奈中的多甲氧基黄酮。在分化早期，它可以调控转录因子，促进 3T3-L1 前脂肪细胞形成脂肪。
T8262	Fosfomycin sodium Fosfomycin Disodium,磷霉素钠	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin sodium 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药的细菌。
TN1661	Ganoderic acid C2 灵芝酸 C2	Reductase; Histamine Receptor; Immunology/Inflammation related	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Ganoderic acid C2 是分离自灵芝的一种三萜化合物，具有潜在的抗肿瘤生物活性，以及抗组胺、抗衰老和细胞毒性作用。它对rat lens aldose reductase 具有很高的抑制活性，IC50为 3.8 µM。
T41358	2-Hydroxybenzylamine	Others	Others
	2-Hydroxybenzylamine 是一种有效的 IsoLG 小分子清除剂，可将活性物质作为惰性加合物螯合。 2-Hydroxybenzylamine 可用于通过减少具有天然生物分子的 IsoLG 加合物来减少心房颤动消融后心房颤动和其他心房心律失常的早期复发。
T10109	3-Carene Delta-3-Carene	COX; Antifungal	Immunology/Inflammation; Microbiology/Virology; Neuroscience
	3-Carene（Delta-3-Carene）是西部落叶松和花旗松中提取的双环单萜烯，可做为植物杀菌剂。3-Carene 对痛觉刺激引起的炎症浸润和 COX-2 过表达有抑制作用。3-Carene 具有抗伤害作用，能促进成骨细胞分化的早期标志物碱性磷酸酶的活性和表达。
T3976	Cytosporone B Csn-B,Dothiorelone G	Others	Others
	Cytosporone B (Dothiorelone G) 是一种天然存在的核孤儿受体Nur77/NR4A1激动剂(EC50=0.278 nM)。
T4947	3-Hydroxybutyric acid Butanoic acid,3-羟基丁酸	Endogenous Metabolite	Metabolism
	3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物，在 I 型糖尿病中升高。它能够调节膜脂的性质。
T19496	Oleuroside	Others	Others
	Oleuroside can protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing.
T17270	Yatein	Others	Others
	Yatein inhibits herpes simplex virus type 1 replication by interruption the immediate-early gene expression. Yatein is a lignan isolated from A. chilensis. It also has antiproliferative activity.
TN3309	9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid	Others	Others
	9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate.
TN2500	1,5,15-Tri-O-methylmorindol	Others	Others
	1,5,15-Tri-O-methylmorindol has effects against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA.
TN2926	3-Epicabraleahydroxylactone	Others	Others
	3-Epicabraleahydroxylactone has anti-tumor promoting effect, it has anti-carcinogenic activity by the inhibitory effect on the induction of Epstein-Barr virus early antigen(EBV-EA) by the tumor promoter.
TN5578	Abieta-8,11,13-triene-7,15,18-triol
	Abieta-8,11,13-triene-7alpha,15,18-triol,7alpha,8alpha,13beta,14beta-diepoxyabietan-18-oic acid, and 18-nor-abieta-8,11,13-triene-4alpha,7alpha,15-triol may have inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tum
TN5961	Gardenolic acid B
	Gardenolic acid B shows promising hepatoprotective effects on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells. Gardenolic acid B shows significant effects on terminating early pregnancy in rats.
TN4421	Latisxanthone C	Others	Others
	Latisxanthone C shows inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, it may be a valuable antitumor promoter.
TN3736	Cycloart-25-ene-3,24-diol	Others	Others
	(24R)-Cycloart-25-ene-3beta,24-diol may be an anti-tumor promoter, it exhibits inhibitory effects on both Epstein-Barr virus early antigen (EBV-EA) and (+/-)-(E)-methtyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3- hexemide (NOR 1) activation.
T14368	Azadirachtin B	Others	Others
	Azadirachtin B, a limonoid derived from the seed kernels of Azadirachta indica, exhibits a broad spectrum of biochemical activities, including insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral, and osteogenic effects. It is effective against the Epstein-Barr virus early antigen (EBV-EA), enhances alkaline phosphatase (ALP) activity, and promotes osteoblast differentiation[1][2][3].
T83281	6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine
	6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine 显著影响细胞器特性，涉及早期内体、线粒体及自噬体（源自帕金森病患者的嗅觉细胞）。
T81813	Methyl lucidenate Q
	Methyl lucidenate Q，一种灵芝甲酯，展现了显著的抑制作用于EBV-EA诱导活性。
TN3321	9-Methoxy-alpha-lapachone	Others	Others
	9-Methoxy-alpha-lapachone has antitumor-promoting effect, it exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein- Barr virus early antigen (EBV-EA) activation in Raji cells.
TN1632	Euparin	Antifection	Microbiology/Virology
	Euparin exhibits a moderate antioxidant activity, it also exhibits antifungal activity against Trichophyton mentagrophytes. Euparin has antiviral activity, it exerts its effect during the early events of the replication cycle, from the virus adsorption to
TN3019	4,9-Dihydroxy-alpha-lapachone	Others	Others
	4,9-Dihydroxy-alpha-lapachone has antitumor-promoting effects, it exhibits significant inhibitory activity against 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced Epstein-Barr virus early antigen (EBV-EA) activation in Raji cells. 4,9-Dihydroxy-alpha-l
TN4999	Serratenediol	BCL; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects being stronger than that of a representative control, oleanolic acid. Serratenediol can promote
TN2928	Pygenic acid A 3-Epicorosolic acid,脓毒酸A
	3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.3-Epicorosolic acid shows both potent α-glucosidase and pro
TN2839	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay o
T75567	Cabenoside D
	Cabenoside D（化合物 8）是从苔藓根的甲醇提取物中分离的一种三萜苷，显示出对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的小鼠炎症的抗炎活性，并能抑制TPA促使的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）激活。
TN4592	Murrangatin	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line,
TN4277	Isocupressic acid	cAMP; P450; PKA	GPCR/G Protein; Metabolism; Tyrosine Kinase/Adaptors
	Isocupressic acid induces abortion in pregnant cows when ingested primarily during the last trimester, it decrease affects the angiogenesis of the female reproductive system, the decrease in blood flow and apoptosis of corpus luteum-derived endothelial ce
T5157	9,13-Epidioxy-8(14)-abieten-18-oic acid	Others	Others
	9,13β-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 ± 0.2 uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 α ,13 β -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory...
TN4140	Glochidiol	Others	Others
	Glochidiol exhibits strong inhibitory effects against all three human tumor cell lines (MCF-7, NCI-H-460 and SF-268), it exerts its antiproliferative activity through the involvement of apoptosis. It exhibits a strong inhibitory effect on mouse skin tumor
TN3607	Catalpalactone	cAMP	GPCR/G Protein
	Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone can inhibit dopamine biosynthesis by
T75566	11-Oxomogroside II A1
	11-Oxomogroside II A1（化合物 7）是一种从罗汉果乙醇提取物中分离的氧化葫芦苷，对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）活化具有抑制效果，并对一氧化氮（NO）供体（+/-）-(E)-甲基-2-[(E)羟基亚氨基]-5-硝基-6-甲氧基-3-己酰胺（NOR 1）的活化也展示出轻微的抑制作用。
TN2977	3-O-trans-p-Coumaroyltormentic acid	Caspase; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, an...
T36791	Lysophosphatidylcholine 18:2
	1-Linoleoyl-2-hydroxy-sn-glycero-3-PC (LGPC) is a lysophospholipid containing linoleic acid at thesn-1 position that has been found in mouse heart, lung, liver, spleen, kidney, plasma, and serum.1Serum levels of LGPC decrease with increasing insulin resistance and dysglycemia in humans.2 1.Okudaira, M., Inoue, A., Shuto, A., et al.Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MSJ. Lipid Res.55(10)2178-2192(2014) 2.Gall, ...

天然产物

3,29-O-Dibenzoyloxykarounidiol

Cat.No: TN1025

Target: Others

Cat.No: T5785

Synonym: Fujioligo 450,Amylotetraose,α-1,4-Tetraglucose,麦芽四糖

Target: TNF, Endogenous Metabolite

3-Hydroxyisovaleric acid

Cat.No: T0613

Synonym: β-羟基异戊酸,Beta-Hydroxyisovaleric acid

Target: Others, Endogenous Metabolite

Stearoylcarnitine

Cat.No: T19564

Synonym: Stearoyl-L-carnitine

Target: Endogenous Metabolite

Poricoic acid B

Cat.No: TN1031

Synonym: 茯苓酸B,茯苓新酸 B

Target: Others

3,5,7,3′,4′-Pentamethoxyflavone

Cat.No: TN2121

Synonym: 栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether

Target: Others

Fosfomycin sodium

Cat.No: T8262

Synonym: Fosfomycin Disodium,磷霉素钠

Target: Antibacterial, Antibiotic

Ganoderic acid C2

Cat.No: TN1661

Synonym: 灵芝酸 C2

Target: Reductase, Histamine Receptor, Immunology/Inflammation related

2-Hydroxybenzylamine

Cat.No: T41358

Target: Others

Cat.No: T10109

Synonym: Delta-3-Carene

Target: COX, Antifungal

Cat.No: T3976

Synonym: Csn-B,Dothiorelone G

Target: Others

3-Hydroxybutyric acid

Cat.No: T4947

Synonym: Butanoic acid,3-羟基丁酸

Target: Endogenous Metabolite

Cat.No: T19496

Target: Others

Cat.No: T17270

Target: Others

9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid

Cat.No: TN3309

Target: Others

1,5,15-Tri-O-methylmorindol

Cat.No: TN2500

Target: Others

3-Epicabraleahydroxylactone

Cat.No: TN2926

Target: Others

Abieta-8,11,13-triene-7,15,18-triol

Cat.No: TN5578

Gardenolic acid B

Cat.No: TN5961

Latisxanthone C

Cat.No: TN4421

Target: Others

Cycloart-25-ene-3,24-diol

Cat.No: TN3736

Target: Others

Cat.No: T14368

Target: Others

6-(1-Hydroxyethyl)-5,6-dihydrochelerythrine

Cat.No: T83281

Methyl lucidenate Q

Cat.No: T81813

9-Methoxy-alpha-lapachone

Cat.No: TN3321

Target: Others

Cat.No: TN1632

Target: Antifection

4,9-Dihydroxy-alpha-lapachone

Cat.No: TN3019

Target: Others

Cat.No: TN4999

Target: BCL, PARP, Caspase

Cat.No: TN2928

Synonym: 3-Epicorosolic acid,脓毒酸A

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid

Cat.No: TN2839

Target: HIV Protease

Cat.No: T75567

Cat.No: TN4592

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

Isocupressic acid

Cat.No: TN4277

Target: cAMP, P450, PKA

9,13-Epidioxy-8(14)-abieten-18-oic acid

Cat.No: T5157

Target: Others

Cat.No: TN4140

Target: Others

Cat.No: TN3607

Target: cAMP

11-Oxomogroside II A1

Cat.No: T75566

3-O-trans-p-Coumaroyltormentic acid

Cat.No: TN2977

Target: Caspase, Antifection

Lysophosphatidylcholine 18:2

Cat.No: T36791

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