70
15
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38776 |
LP-922056
|
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
LP-922056 是 Notum Pectinacetylesterase 的抑制剂,对人和小鼠的 EC50 值分别为 21 nM 和 55 nM。 | |||
T3198L |
PRE-084 hydrochloride
|
Sigma receptor | GPCR/G Protein |
PRE-084 hydrochloride 是 σ1 的选择性激动剂在sigma 受体检测中,IC50值为44 nM。 | |||
T3217 |
PF-CBP1 hydrochloride
PF-CBP1 HCl |
Epigenetic Reader Domain; Histone Acetyltransferase | Chromatin/Epigenetic |
PF-CBP1 hydrochloride (PF-CBP1 HCl) 是 CREB 结合蛋白溴结构域的一种高选择性抑制剂,抑制 CREBBP 和 EP300溴结构域的 IC50分别为 125 和 363 nM。它降低 LPS 诱导的巨噬细胞中炎症因子的表达,也可下调皮质神经元 RGS4 的表达,可用于癫痫和帕金森病等神经疾病的研究。 | |||
T21460 |
Teriparatide acetate
hPTH 1-34 (acetate salt),Parathar acetate,Forteo,醋酸立特帕肽 |
Others | Others |
Teriparatide acetate (Forteo) 是一种 PHT 激动剂,在 HEK293 细胞中的 IC50 为 2 nM。Teriparatide acetate 是一种重组形式的甲状旁腺激素。它是一种有效的合成代谢(即骨骼生长)剂,用于治疗某些形式的骨质疏松症。间歇使用特立帕肽比破骨细胞更能激活成骨细胞,从而导致骨骼整体增加。 | |||
T12472 |
Pifithrin-α, p-Nitro, Cyclic
PFN-α |
p53 | Apoptosis |
Pifithrin-α, p-Nitro, Cyclic (PFN-α) 是 p53 的细胞渗透性和活性形式抑制剂。它对暴露于 Etoposide 的皮层神经元的保护作用比 Pifithrin-α 强一个数量级,ED50为30 nM。它也作为 p53 转录后的活性抑制剂。 | |||
T22517 |
5,7-Dichlorokynurenic acid
5,7-二氯犬尿喹啉酸,5,7-dichlorokynurenic acid sodium,5,7-DCKA |
NMDAR | Neuroscience |
5,7-Dichlorokynurenic acid (5,7-dichlorokynurenic acid sodium) 是一种专门针对于NMDA 受体甘氨酸位点的竞争性拮抗剂(KB:65 nM)。它是犬尿酸的衍生物,可降低大鼠皮质细胞培养物中 NMDA 诱导的神经元损伤程度。 | |||
TP2045 |
CH 275
|
||
Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin release in the rat nucleus accumbens | |||
T21584 |
CP 465022
|
iGluR | Membrane transporter/Ion channel; Neuroscience |
CP 465022 hydrochloride 是强效的、选择性的AMPA 受体非竞争性拮抗剂,具有抗惊厥活性。CP 465022 hydrochloride 在大鼠皮层神经元中抑制Kainate 诱导的反应 (IC50= 25 nM)。 | |||
T11217 |
Eplivanserin
依利色林,SR-46349 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Eplivanserin (SR-46349) 是一种有效和特异性的 5-HT2A 受体拮抗剂,Kd 值为 1.14 nM,在大鼠皮质膜中 IC50 值为 5.8 nM。 | |||
T14490 |
Talipexole dihydrochloride
Domnin,盐酸他利克索,B-HT 920 dihydrochloride |
Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Talipexole dihydrochloride (Domnin) 是一种多巴胺 D2 受体激动剂、α2-肾上腺素受体激动剂和 5-HT3 受体拮抗剂,有抗帕金森病活性。 | |||
T69467 |
Azacosterol
IMD760,Diazasterol |
Others | Others |
Azacosterol (Diazasterol) 是一种DHCR24抑制剂。Azacosterol 口服或腹腔注射后会在皮质神经元中发生一系列反应。 | |||
TP1140L |
Neuropeptide Y (29-64), amide, human acetate
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Neuropeptide Y (29-64), amide, human acetate 参与阿尔茨海默病 (AD) 并保护大鼠皮质神经元免受 β-淀粉样蛋白毒性。 | |||
T11684 |
Isoguvacine hydrochloride
1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride,异四氢烟酸 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Isoguvacine hydrochloride (1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride) 是 GABA 受体激动剂。它与大鼠突触皮质膜结合并激活 α1β2γ2S、α2β2γ2S、α3β2γ2S、α5β2γ2S 和 ρ1 亚基 GABAA 受体。 | |||
T9691L |
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate
|
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate 是一种高效的甲状旁腺激素 (PTH) 拮抗剂,在牛肾皮质膜中的 Ki 值为 69 nM。 | |||
T10162 |
5-HT3 antagonist 3
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
5-HT3 antagonist 3 是一种高亲和力的 5-HT3 受体拮抗剂。5-HT3 antagonist 3 结合到大鼠脑皮质膜中的 5-HT3 受体,Ki 为 0.25 nM。 | |||
T10998 |
Deriglidole
SL 86-0715 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Deriglidole (SL 86-0715) 是一种外周肾上腺素能受体拮抗剂,是一种具有选择性的α2受体抑制剂。 Deriglidole 对可乐定和 Idazoxan 有抑制作用而对哌唑嗪与大鼠皮质和人血小板α2-肾上腺素能受体不显示活性。 | |||
T23394 |
SR 57227A
SR57227盐酸盐,SR 57227 hydrochloride |
5-HT Receptor | GPCR/G Protein; Neuroscience |
SR 57227A (SR 57227 hydrochloride) 是一种有效的、具有口服活性和选择性的 5-HT3 受体激动剂,具有穿越血脑屏障的能力和抗抑郁作用。它对大鼠皮质膜和整个 NG 108-15 细胞或其膜上的 5-HT3 受体结合位点的亲和力,IC50在 2.8 至 250 nM 之间。 | |||
TP1223L |
Apamin acetate
Apamine acetate,Apamin acetate(24345-16-2 Free base) |
Potassium Channel | Membrane transporter/Ion channel |
Apamin acetate (Apamine acetate) 是一种具有选择性的 Ca2+ 激活的 K+ (SK) 通道的阻断剂,是在蜂毒素中发现的一种 18 个氨基酸的肽类神经毒素。Apamin acetate 可增强皮质神经元撕裂损伤后的神经突生长和再生。Apamin acetate 具有抗炎和抗纤维化的作用。 | |||
T0939 |
Phenytoin
苯妥英,Diphenylhydantoin,5,5-Diphenylhydantoin |
Virus Protease; Sodium Channel | Membrane transporter/Ion channel; Microbiology/Virology |
Phenytoin (5,5-Diphenylhydantoin) 是一种有效的电压门控钠离子通道阻滞剂,可减少小鼠乳腺肿瘤的生长和转移,具有抗癫痫活性。 | |||
T3486 |
3-MATIDA
|
GluR; NMDAR | Neuroscience |
3-MATIDA 是一种有效的 mGluR-1 拮抗剂(IC50:6.3 μM,大鼠 mGluR-1a)。显示出 ≥ 40 倍于其他受体的选择性:mGluR-5、mGluR-2、mGluR-4 (mGluR-4a) (IC50 > 300 μM)、NMDA 和 GluR (AMPA) (IC50 = 250 μM)。 3-MATIDA 在体外培养的鼠皮质细胞和大鼠海马切片培养物中充当神经保护剂。 | |||
T70540 |
Pinokalant
LOE-908 |
SARS-CoV; TRP/TRPV Channel | Membrane transporter/Ion channel; Microbiology/Virology |
Pinokalant (LOE-908) 是一种新型非选性阳离子通道抑制剂。Pinokalant 在体内实验中可显著减少皮质梗死体积,可改善缺血半影区的代谢和电生理状态,可减少大鼠大脑中动脉闭塞后急性期磁共振图像上的病变大小。Pinokalant是一种潜在的SARS-CoV-2蛋白酶抑制剂,可用于研究脑卒中。 | |||
T36141 |
Boscalid
|
Mitochondrial Metabolism | Metabolism |
Boscalid 是一种广谱羧酰胺类杀菌剂,通过与线粒体复合物 II/琥珀酸脱氢酶的泛醌位点结合来抑制真菌呼吸。 | |||
T26482 |
A-57696
|
||
A-57696 is a cholecystokinin antagonist with selective for cortical CCK-B receptors (IC50 = 25 nM). | |||
T0068L |
Fluphenazine Decanoate Dihydrochloride
|
||
Fluphenazine Decanoate Dihydrochloride is an antipsychotic agent, it could block postsynaptic dopamine D2 receptors in the limbic, cortical system and basal ganglia. | |||
T36446 |
Neuropeptide Y (human) (TFA)
|
||
Neuropeptide Y (human) TFA, a compound implicated in Alzheimer's disease (AD), exhibits protective effects against β-Amyloid toxicity in rat cortical neurons. | |||
TP1338 |
Neuropeptide Y (29-64), amide, human TFA
|
||
Neuropeptide Y (29-64), amide, human (TFA) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.It is showed that Neuropeptide Y (29-64), amide, human (TFA) is able to protect cortical neurons from Aβ25-35 t | |||
T8456 |
GALNON
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Galnon 是一种甘丙肽受体激动剂,可改善内在的皮质骨组织特性。 | |||
T71554 | ARN 14494 | ||
ARN 14494 is a potent serine palmitoyltransferase inhibitor (SPT; IC50 = 27.3 nM). ARN 14494 inhibits synthesis of long chain ceramides and dihydroceramides in an in vitro model of Alzheimer's diease. The compound prevents the synthesis of proinflammatory cytokines and the oxidative stress-related enzymes iNOS and COX-2 in mouse primary cortical astrocytes. ARN 14494 is neuroprotective against β-amyloid 1-42 induced neurotoxicity in primary cortical neurons co-cultured with astrocytes. | |||
T38610 |
Pirepemat
IRL752 |
||
Pirepemat (IRL752) is a cortical-preferring catecholamine agent that enhances cognition. It is utilized in the investigation of Parkinson's disease. | |||
T70916 |
AGN-190851
|
||
AGN-190851 is an alpha-2 adrenoceptor agonist which acts as a water diuretic by inhibiting vasopressin-stimulated cyclic AMP accumulation in cortical collecting tubules in mouse models. | |||
T71733 | VU0606170 | ||
VU0606170 is a slack channels inhibitor and was shown to successfully decrease the malfunctioning spontaneous firing rate of cortical neurons, providing a potential avenue for achieving an anti-epileptic effect not previously attainable. | |||
T28850 |
SR57227A
SR 57227A,SR-57227A |
||
SR 57227A is a highly selective of peripheral and central 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive beh | |||
T60950 |
Pirepemat fumarate
|
||
Pirepemat (IRL752) fumarate 可用于研究帕金森病。Pireemat fumarate 是一种偏向皮质的儿茶酚胺传递剂和认知促进剂。 | |||
T16155 | MSN-125 | Akt | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling |
MSN-125 effectively inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons protect primary neurons against glutamate excitotoxicity. MSN-125 is an effective Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochond | |||
T29809 |
AL-1
AL 1,AL1 |
||
AL-1 is a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR containing ephrin found in developing tectum. It can mediate the bundling of cortical axons and repel the axonal growth of retinal ganglia axons. It exists in a variety of adult tissues of BRAIN; HEART; | |||
T0068L2 |
Fluphenazine free base
Siqualine,Fluphenazine,Fluorophenazine,Fluorphenazine,Triflumethazine,Fluorfenazine |
||
Flufenazine is an antipsychotic drug. It is used to treat chronic mental illnesses such as schizophrenia. Flufenazine works by blocking postsynaptic dopamine D2 receptors in the limbic system, cortical system, and basal ganglia. This prevents the effects | |||
T40510 |
Ac-RYYRWK-NH2 TFA
Ac-RYYRWK-NH2 TFA |
||
Ac-RYYRWK-NH2 is a highly effective and specific partial agonist for the nociceptin receptor (NOP). It demonstrates a remarkable affinity for rat cortical membranes ORL1, with [3H]Ac-RYYRWK-NH2 exhibiting a Kd value of 0.071 nM. However, it shows negligible affinity towards μ-, κ-, or δ-opioid receptors. | |||
T3648 |
Hypidone hydrochloride
YL0919 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Hypidone hydrochloride (YL0919) 是一种新型抗抑郁候选药物,具有作为 5-HT1A 受体激动剂和选择性 5-羟色胺再摄取抑制剂的双重活性。 | |||
T73408 | Immepip | ||
Immepip 是一种 H3激动剂。Immepip 可以减少皮质组胺的释放。Immepip 可用于神经系统疾病的研究。 | |||
T37203 |
CCK (26-30) (sulfated)
|
||
CCK (26-30) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. The sulfated form of CCK (26-30) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 10% when used at a concentration of 0.1 mM. | |||
T29002 |
Trazium Esilate
EGYT3615,EGYT-3615,EGYT 3615 |
||
Trazium esilate is an adrenergic receptor antagonist. Trazium esilate is a weak displacer on a1-, a2- and D2-receptors, however, it induced a2-receptor desenzitization after repeated treatment. It had no influence on rat brain cortical noradrenaline and s | |||
T37661 |
LY 2886721 Hydrochloride
|
||
Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model. | |||
T79784 |
VU6004909
|
||
VU6004909为mGlu5受体正构效应调节剂,pEC50值为7.59。其具有抗精神病样效应,并能逆转MK801引起的皮质活动增强和认知功能障碍。 | |||
TP2060 |
Conantokin G
|
||
GluN2B (formally NR2B) selective, competitive antagonist of the NMDA receptor. Blocks NMDA-evoked current in mouse cortical neurons (IC50 = 480 nM); also inhibits NMDA-evoked responses in oocytes expressing GluN2B (formally NR2B), but not GluN2A (formally | |||
T81899 | LY836 | iGluR | Membrane transporter/Ion channel; Neuroscience |
LY836是口服活性神经保护剂,有效阻断皮层神经元中PSD95-nNOS的关联,适用于缺血性脑卒中研究。 | |||
T37205 |
CCK (26-31) (sulfated)
|
||
CCK (26-31) is an N-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. The sulfated form of CCK (26-31) inhibits binding of [125I]CCK-33 to guinea pig cortical membranes by 21% when used at a concentration of 0.1 mM. | |||
T21875 |
CP-465022 (maleate)
|
||
CP-465022 Maleate is a potent, selective, noncompetitive AMPA receptor antagonist with anticonvulsant activity. It effectively counters the Kainate-induced response in rat cortical neurons, exhibiting an IC 50 of 25 nM. As such, CP-465022 Maleate presents a valuable instrument for studying the involvement of AMPA receptors in various physiological and pathophysiological processes [1] [2]. | |||
T35920 |
N-methyl Paroxetine
|
||
N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM). It inhibits serotonin uptake in rat brain synaptosomes with an IC50 value of 22 nM. N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine. | |||
T36811 |
uPSEM 817 tartrate
|
||
Selective ultrapotent PSEM (uPSEM) agonist for α7L131G,Q139L,Y217F-GlyR (PSAM4-GlyR) and PSAM4-5-HT3 chimeric ion channel agonist (EC50 values are 0.3 and 0.5 nM, respectively). Suppresses firing of layer 2/3 cortical neurons expressing PSAM4-GlyR in brain slices. Increases contralateral rotation in mice expressing PSAM4-GlyR unilaterally in the substantia nigra reticulata (LED 0.1 mg/kg). Magnus et al (2019) Ultrapotent chemogenetics for research and potential clinical applications. Science 3... | |||
T76061 |
Parathyroid hormone (1-34) (rat) acetate
|
||
Parathyroid hormone (1-34) (rat) (acetate) 是一种甲状旁腺激素,主要用于骨质疏松症的研究,具有改善皮质和松质骨结构的功能。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN5131 |
Tetrahydrocannabivarin
THCV,delta9-Tetrahydrocannabivarin,CRM,Tetrahydrocannavarin |
Cannabinoid Receptor | GPCR/G Protein |
Tetrahydrocannabivarin (CRM) 是 cannabinoid type 1 receptor 的中性拮抗剂,对 2 型糖尿病有潜在治疗价值。 | |||
T6S1418 |
Praeruptorin C
|
Antioxidant; Calcium Channel | Membrane transporter/Ion channel; Metabolism; oxidation-reduction |
Praeruptorin C 是白花前胡中的一种主要成分,是钙拮抗剂,pD2′值为 5.7。 | |||
T5S2129 |
Sciadopitysin
|
TNF; NF-κB | Apoptosis; NF-κB |
Sciadopitysin 是一种双黄酮类化合物,来自银杏叶片中。它通过抑制NF-κB 活化并降低c-Fos 和NFATc1的表达来抑制 RANKL 诱导的破骨细胞生成和骨丢失。 | |||
TN2037 |
Paeonilactone C
(3S,3AR,6S,7AR)-3-[(苯甲酰基氧基)甲基]四氢-6-羟基-6-甲基-2,5(3H,4H)-苯并呋喃二酮,芍药内苷 C |
Others | Others |
Paeonilactone C significantly protects primary cultures of rat cortical cells against H2O2-induced neurotoxicity. | |||
TN5169 |
Traxillaside
香榧 |
Others | Others |
Traxillaside has significant neuroprotective activities against glutamate-induced toxicity in primary cultures of rat cortical cells . | |||
TN2257 |
Tanshinone IIB
丹参酮ⅡB |
BCL; Caspase; P-gp | Apoptosis; Membrane transporter/Ion channel; Neuroscience; Proteases/Proteasome |
Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the elevated Bax protein and decreased bc | |||
TN3771 |
Dasycarpol
|
Others | Others |
Dasycarpol(9beta-Hydroxyfraxinellone) shows significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at a concentration of 0.1 microM. Dasycarpol also shows moderate inhibitory activity on lung | |||
TCA2511 |
11Beta-hydroxyprogesterone
|
Sodium Channel | Membrane transporter/Ion channel |
The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone in the rat in vivo. 11beta-Hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells. | |||
TN2036 |
Paeonilactone B
(+)-Paeonilactone B |
NADPH-oxidase | Immunology/Inflammation |
Paeonilactone B ((+)-Paeonilactone B) 是一种来自白芍的单萜类化合物,具有神经保护活性,抑制氧化应激,在大鼠皮质细胞在抑制 H2O2 诱导的神经毒性。 | |||
T16846 |
Sauristolactam
Saurolactam |
Others | Others |
Sauristolactam inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation. Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus Chi | |||
T83288 | 5-Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone | ||
Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone 是一种神经保护剂,对谷氨酸诱导的大鼠皮质细胞原代培养显示显著的神经保护效果。 | |||
TN4286 | Isodunnianol | NOS; NF-κB; ROS; AChR | Immunology/Inflammation; Neuroscience; NF-κB |
Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the primary cultured rat cortical neurons. Isodunnianol, dunnianol, and Macrant | |||
TN3444 |
Aristolactam BII
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Aristolactam BII exhibits antimicrobial and antiinflammatory activity, it shows significant activity towards DPPH radical scavenging and potent inhibitory effects against tyrosinase mushroom. Aristolactam BII also exerts its significant neuroprotective ef | |||
T75890 |
Conantokin G TFA
|
||
Conantokin G TFA 是一种 17 个氨基酸的肽,是一种有效,选择性和竞争性的 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂。Conantokin G TFA 抑制鼠皮质神经元中NMDA 诱发的电流,IC50为 480 nM,具有神经保护作用。 | |||
TN5164 |
trans-Hinokiresinol
|
IL Receptor; TNF; NOS; LTR | Apoptosis; Immunology/Inflammation |
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyasol (cis-hinokiresinol) are estrogen |