42
17
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T72322 |
R 59-022 hydrochloride
DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride |
5-HT Receptor; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; Neuroscience |
R 59-022 hydrochloride (DKGI-I hydrochloride) 是一种 5-HT Receptor 拮抗剂,可激活蛋白激酶 C (PKC)。R 59-022 hydrochloride 是一种 DGK 抑制剂 (IC50:2.8 µM),可抑制 OAG 磷酸化为 OAPA。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生,并抑制嗜中性粒细胞中磷脂酸的产生。 | |||
T12620 |
(R)-CSN5i-3
|
Others | Others |
(R)-CSN5i-3 是 R 构型的 CSN5i-3 。 | |||
T16709 |
R 59-022
Diacylglycerol kinase inhibitor I,DKGI-I |
Others | Others |
R 59-022 is a 5-HTR antagonist and activates protein kinase C (PKC). R 59-022 is a diacylglycerol kinase inhibitor (IC50=2.8 μM). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neu | |||
T8476 |
RSVA405
RSVA 405 |
AMPK; STAT; Autophagy | Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Stem Cells |
RSVA405 是一种具有口服活性的AMPK 激活剂,EC50值为 1 μM。它也是一种 STAT3 抑制剂,具有抗炎作用,可研究肥胖症。它通过促进 CaMKKβ 依赖的 AMPK 活化,从而抑制mTOR,并促进自噬以增加 Aβ 的降解。 | |||
T6547 |
Ipratropium Bromide
Sch 1000,异丙托溴铵,Itrop,Atrovent |
AChR | Neuroscience |
Ipratropium Bromide (Sch 1000) 是毒蕈碱的受体的拮抗剂,可用于 COPD 和哮喘等研究,对 M1、M2 和 M3 受体的结合的IC50值分别为 2.9、2 和 1.7 nM。 | |||
T19930 |
Nitrosoglutathione
S-Nitrosoglutathione,S-亚硝基谷胱甘肽,SNOG,Glutathione thionitrite,GSNO |
RAAS; NO Synthase | Endocrinology/Hormones; Immunology/Inflammation |
Nitrosoglutathione (GSNO) 是一种外源性的 NO 供体,是大鼠酒精脱氢酶III 类同工酶的底物,能够减少脑血管紧张素II 依赖性及非依赖型的 AT1 受体反应。 | |||
T0098 |
Ipratropium bromide monohydrate
Ipratropium bromide hydrate,溴化异丙托品单水合物 |
AChR | Neuroscience |
Ipratropium bromide monohydrate (Ipratropium bromide hydrate) 是一种毒蕈碱拮抗剂,结构上与阿托品相关,但它通常被认为对吸入使用更安全、更有效。它用于各种支气管疾病、鼻炎和抗心律失常。 | |||
TD0001 |
SYBR GREEN 1
SUPER Green I (效果同SYBR Green I)核酸染料(10,000× DMSO溶液)(电泳级),SYBR(R) GREEN I NUCLEIC ACID GEL STAIN *10,000× concentrate in DMSO,SYBRGREENⅠ核苷酸胶体染料 |
Others | Others |
SYBR GREEN 1 是一种不对称花青染料,用于检测核酸。它由一个 N-烷基化的苯并噻唑或苯并恶唑环系统组成,通过一甲基桥连接到吡啶鎓或喹啉鎓环系统。 SYBR Green I 与 dsDNA 的小沟结合,在 480 nm 波长处被激发。它具有 520 nm 的峰值荧光发射。 | |||
T16708 |
R-268712
|
ALK; TGF-beta/Smad | Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors |
R-268712 是选择性的 ALK5 抑制剂(IC50:2.5 nM)。 | |||
T27335 |
Floctafenine
RU 15750,R-4318,R 4318,RU-15750,R4318 |
COX | Immunology/Inflammation; Neuroscience |
Floctafenine (R-4318) 是一种可口服的非甾体抗炎化合物,是 COX-I 和 COX-2 抑制剂,可干扰阿司匹林的抗血小板作用。Floctafenine 具有镇痛活性,可用于研究疼痛。 | |||
T4191 |
Multi-kinase inhibitor 1
Multi-kinase inhibitor I |
Others; Bcr-Abl; PDGFR; c-Kit | Angiogenesis; Cytoskeletal Signaling; Others; Tyrosine Kinase/Adaptors |
Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) 是多激酶抑制剂。它有用于导致与酪氨酸激酶活性异常或失控有关的疾病或失调的潜力,特别是与c-Kit,PDGF-R,Bcr-abl 活性相关的疾病。 | |||
T30981 |
Clometocillin
Penicilline 356 |
||
Clometocillin is a penicillin that can active penicillin to pen-I or pen-R pneumococci. | |||
T15672 | KU14R | Others | Others |
KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines. | |||
T33451 |
ML 7
ML7,ML-7 |
||
ML 7 is an inhibitor of myosin light chain kinase that protects cardiac function from ischemia/reperfusion (I/R) injury. | |||
T61491 |
(R)-ND-336
|
||
(R)-ND-336 is a highly potent and selective MMP-9 inhibitor, displaying a K i value of 19 nM. It also exhibits inhibitory activity against MMP-2 (K i = 127 nM) and MMP-14 (K i =119 nM). With its significant potential, (R)-ND-336 is being investigated in the field of diabetic foot ulcers (DFUs) research [1]. | |||
T39870 |
5-HT7R antagonist 1 free base
5-HT7R antagonist 1 free base |
||
5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM. | |||
T74723 | MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan | ||
MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan 是一种抗体偶联活性分子的一部分 (drug-linker conjugate for ADC),包含 Exatecan 。Exatecan 是一种 DNA 拓扑异构酶 I (Topoisomerase I) 抑制剂 (IC50=2.2 μM)。 | |||
T22140 |
(R)-SLV 319
|
||
(R)-SLV 319 是一种有效的、选择性的大麻素受体 1 (CB1)拮抗剂,Ki 值为 894 nM。(R)-SLV 319 是 SLV 319 的右旋对映体。 | |||
T61980 | Carbonic anhydrase inhibitor 8 | ||
Carbonic anhydrase inhibitor 8 (compound R-13) 是一种有效的人碳酸酐酶 (hCA) 抑制剂。Carbonic anhydrase inhibitor 8抑制 hCA I、hCA II、hCA IV 的Ki 值分别为 60.7 nM、320.7 nM、2298 nM。 | |||
T39795 |
Tricarbonyldichlororuthenium(II) dimer
CORM-2 |
||
Tricarbonyldichlororuthenium(II) dimer, a pharmacological CO donor, prevents ischemia/reperfusion (I/R)-induced oxidative damage to the gastric mucosa by enhancing gastric blood flow (GBF) and reducing DNA oxidation and systemic inflammatory response. | |||
T71001 | GSK-598809 | ||
GSK598809 is a selective D(3)R antagonist recently progressed in Phase I trials. GSK-598809 may decrease the rewarding effects of contextual cues associated with drug intake preclinically, which may reduce drug craving in humans. | |||
T61982 | Human carbonic anhydrase II-IN-2 | ||
Human carbonic anhydrase II-IN-24 (Compound R-13) 是一种有效的人碳酸酐酶(hCA)抑制剂。Human carbonic anhydrase II-IN-24抑制 hCA I、II、IV 和 IX 的 Ki 分别为 60.7、320.7 和 2298 和 35.2 nM。 | |||
T83043 |
Anti-MI/R injury agent 1
|
||
Anti-MI/R injury agent 1 (compound 18) 是一种口服有效的人参三醇衍生物,专用于抗心肌缺血/再灌注 (MI/R) 损伤。该化合物能增强经氧-葡萄糖剥夺和再灌注 (OGD/R) 诱导心肌细胞损伤模型中的细胞活力,显着缩小大鼠心肌梗死面积,减少循环心肌肌钙蛋白 I (cTnI) 的释放,并减轻心脏组织损害。 | |||
T37680 |
3-hydroxy Palmitic Acid methyl ester
|
||
3-hydroxy Palmitic acid methyl ester (3-hydroxy PAME) is an esterized long-chain fatty acid involved in quorum sensing in R. solanacearum, a bacteria that causes lethal wilting in plants. 3-hydroxy-PAME (175 nM) increases levels of PhcA-regulated virulence factors, greater than 20-, 30-, and 25-fold for EPS I, EGL, and PME, respectively, in the AW1-83 strain of R. solanacearum. | |||
T74331 | hCAII-IN-7 | ||
hCAII-IN-7 (Compound R-13) 是一种有效的人碳酸酐酶(hCA)抑制剂,对 hCA I、II、IV 和 IX 的 Ki 分别为 60.7、320.7 和 2298 和 35.2 nM。 | |||
T81267 |
RIPK3-IN-4
|
RIP kinase | Apoptosis; NF-κB |
RIPK3-IN-4(Compound 42)是一种抑制RIPK3活性的化合物。它能有效减轻HK-2细胞的损伤和凋亡(necroptosis),同时降低急性肾损伤中(Cisplatin)以及缺血/再灌注(I/R)引起的肾脏损伤、炎症及坏死性凋亡现象。 | |||
T74724 | MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan | ||
MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan 是抗体偶联活性分子的一部分 (drug-linker conjugate for ADC),包含 Exatecan 。Exatecan 是一种 DNA 拓扑异构酶 I (Topoisomerase I) 抑制剂 (IC50=2.2 μM)。 | |||
T76223 | NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) | ||
NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) (化合物 39) 作为APJ激动剂表现出高亲和力,其Ki值为0.6 nM。该化合物能有效激活Gαi1,具有EC50值0.8 nM,并能募集β-arrestin2,相关EC50值为31 nM。同时,NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) 对心脏功能具有显著的延长作用。 | |||
T80138 |
(D-Arg8)-Inotocin
|
Vasopressin Receptor | GPCR/G Protein |
"(D-Arg8)-Inotocin"是一种对加压素受体V1aR表现出高效、选择性和竞争性拮抗作用的化合物,其Ki值为1.3 nM。该化合物对人类V1aR具有显著的选择性,相较于其他三种亚型(OTR, V1bR, V2R),其选择性超过3000倍。 | |||
T38329 |
CU-76
|
||
CU-76 is an inhibitor of cyclic GMP-AMP synthase (cGAS; IC50= 0.24 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. CU-76 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM. 1.Padilla-Salinas, R., Sun, L., Anderson, R., et al.Discovery of small-molecule cyclic GMP-AMP sy... | |||
T37887 |
1-Heptadecanoyl-rac-glycerol
|
||
1-Heptadecanoyl-rac-glycerol is a monoacylglycerol that contains heptadecanoic acid at the sn-1 position. It is active against the bacteria E. aerogens, E. cloacae, P. mirabilis, and S. faecalis (MIC = 78 μg/ml for all).1 1-Heptadecanoyl-rac-glycerol has been found in T. africana, I. sonorae, and wheat bran.1,2,3 |1. Kuete, V., Metuno, R., Ngameni, B., et al. Antimicrobial activity of the methanolic extracts and compounds from Treculia africana and Treculia acuminata (Moraceae). S. Afr. J. Bot. ... | |||
T38328 |
CU-32
|
||
CU-32 is an inhibitor of cyclic GMP-AMP (cGAMP) synthase (cGAS; IC50= 0.45 μM).1It reduces DNA-, but not Sendai virus-, induced dimerization of IFN regulatory factor 3 in THP-1 cells, indicating selectivity for the cGAS DNA sensing pathway over the RIG-I-MAVS RNA sensing pathway. It is also selective for cGAS over toll-like receptors (TLRs) at 50 μM. CU-32 decreases IFN-stimulatory DNA-induced production of IFN-β in THP-1 cells when used at concentrations of 10, 30, and 100 μM. 1.Padilla-Salinas... | |||
T72091 |
ADRA1D receptor antagonist 1 free base
|
||
ADRA1D receptor antagonist 1 (free base) (化合物 (R)-9s),是口服高效、强效及选择性的人类α1D-肾上腺素受体(α1D-AR)拮抗剂,具有Ki值为1.6 nM。该化合物能剂量依赖性降低膀胱收缩,IC30值为15 nM,适用于膀胱过度活动症(包括尿急、尿频和尿失禁)的研究。 | |||
T35762 | MC1742 | ||
MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).1 It is selective for class I and class IIb over class IIa HDACs (IC50s = >50 μM for HDAC4, -5, -7, and -9). MC1742 reduces proliferation of HOS, MG-63, RD, A204, SK-ES-1, and A673 sarcoma cancer stem cells (CSCs). It increases levels of acetylated histone H3 and acetylated tubulin... | |||
T37536 | Carbazomycin A | ||
Carbazomycin A is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2It is active againstS. aureus,T. asteroides, andT. mentagrophytes(MIC = 12.5 μg/ml for all), as well as the plant pathogenic fungusP. oryzae(MIC = 25 μg/ml). Carbazomycin A is cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 26.2, 30.1, 18.4, and 32.6 μg/ml, respectively).2 1.Sakano, K.-I., Ishimaru, K., and Nakamura, S.New antibiotics, carbazomycins A and B. I. Fermenta... | |||
T36929 |
Pal-KTTKS (acetate)
|
||
Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%.2 Following topical administration, pal-KTTKS (50 μg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin.1 It can self-assemble into flat tapes and extended fibrillar structures.3 Pal-KTTKS... | |||
T36679 | Rp-cAMPS sodium salt | ||
Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6]. A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic t... | |||
T38284 |
C24 dihydro 1-Deoxyceramide (m18:0/24:0)
C24 dihydro 1-Deoxyceramide (m18:0/24:0) |
||
C24 dihydro 1-Deoxyceramide (m18:0/24:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C24 dihydro 1-Deoxyceramide (m18:0/24:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found in mouse brain, spinal cord, ... | |||
T83765 |
Dendrogenin A
DDA |
||
Dendrogenin A (DDA) 作为一种选择性肝X受体(LXR)调节剂(SLiM)、胆固醇环氧水解酶(ChEH; Ki = 120 nM)的抑制剂及胆固醇的活性代谢产物,通过DDA合成酶将5,6α-环氧胆固醇与组胺结合形成。DDA在非癌性人乳腺上皮细胞和上皮黑色素细胞中存在,但在多种乳腺癌细胞或黑色素瘤细胞中未发现,且在分离的人乳腺肿瘤组织中仅以低水平存在。它抑制22(R)-羟基胆固醇诱导的LXRβ和LXRα激活(分别以IC50 = 76和362 nM),但也是LXR的部分激动剂,在B16/F10小鼠黑色素瘤细胞中增加Nur77、NOR-1、LC3-I和LC3-II的蛋白水平。DDA选择性调节LXRα和LXRβ,而非孕烯X受体(PXR)、芳香烃受体(AhR)、维生素D受体(VDR)、维甲酸X受体γ(RXRγ)、维甲酸受体α(RARα)、过氧化物酶体增殖物激活受体α(PPARα)、PPARγ、糖皮质激素受体、雄激素受体、雌激素受体α(ERα)及ERβ在2.5 µM下。此外,DDA在2.5和5 µM的浓度下增加B16/F10和SK-MEL-28癌细胞中LC3-II的蛋白水平,并在2... | |||
T38280 |
C22 dihydro 1-Deoxyceramide (m18:0/22:0)
C22 dihydro 1-Deoxyceramide (m18:0/22:0) |
||
C22 dihydro 1-Deoxyceramide (m18:0/22:0) is a very long-chain atypical ceramide containing a 1-deoxysphinganine backbone. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 C22 dihydro 1-Deoxyceramide (m18:0/22:0) has been found in mouse embryonic fibroblasts (MEFs) following application of 1-deoxysphinganine alkyne or 1-deoxysphinganine-d3.3 It has also been found as the most prevalent dihydro... | |||
T36892 | 4'-Acetyl Chrysomycin A | ||
4'-Acetyl chrysomycin A is a bacterial metabolite and derivative of chrysomycin A that has been found inStreptomycesand has antibacterial and anticancer activities.1It is active against strains of methicillin-resistantS. aureus(MRSA) and vancomycin-resistant strains ofE. faecalisandE. faecium(MICs = 0.5-2 μg/ml for all). 4'-Acetyl chrysomycin A is cytotoxic against a panel of human cancer cell lines, including doxorubicin-sensitive or -resistant cells (IC50s = 0.085-0.26 and 3.4-16 ng/ml, respec... | |||
T38214 |
1-Deoxysphingosine (m18:1(4E))
1-Deoxysphingosine (m18:1(4E)) |
||
1-Deoxysphingosine (m18:1(4E)) is an atypical sphingolipid that contains a double bond at the 4E native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 Plasma levels of 1-deoxysphingosine (m18:1(4E)) are increased in patients with chronic idiopathic axonal neuropathy (CIAP) and diabetic distal symmetrical polyneuropathy (DSPN).3 |1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemica... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1895 |
Luteolinidin chloride
|
CD38 | Immunology/Inflammation |
Luteolinidin chloride 是天然的脱氧花青素,分离自苔藓和蕨类植物中。它是一种有效的 CD38 抑制剂,可以保留 eNOS 功能并预防体内内皮功能障碍,同时可以保护心脏免受 I/R 损伤。 | |||
T2961 |
Notoginsenoside R1
Sanqi glucoside R1,Sanchinoside R1,三七皂苷R1 |
Apoptosis; ERK; Beta Amyloid | Apoptosis; MAPK; Neuroscience |
Notoginsenoside R1 (Sanchinoside R1) 是一种从三七中分离出来的皂苷,具有抗氧化、抗炎、抗血管生成和抗凋亡的活性。它有神经保护和抗缺血/再灌注损伤的心脏保护作用。 | |||
T21328 |
Carubicin
carminomycin,Carminomycin I,Carminomicin I,Antibiotic R 588A,Demethyldaunomycin |
||
Carubicin is an anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. | |||
TN5997 |
Stipuleanoside R1
Tarasaponin I,屏边三七苷R1 |
||
Stipuleanoside R1 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5997,CAS号为 96627-79-1。 | |||
T5S1262 |
Methylophiopogonanone A
|
Others | Others |
Methylophiopogonanone A 是从Ophiopogon japonicas 提取到的黄酮类化合物,具有抗炎和抗氧化的特性。它通过调节 MMP-9 和紧密连接蛋白的表达来减轻 BBB 破坏的能力,具有治疗脑 I/R 损伤的潜力。 | |||
T5S1632 |
Barlerin
8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01 |
VEGFR; TNF; NF-κB; Akt; Caspase | Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷,从中国西藏民间药用植物中分离得到,能够抑制NF-κB 活性。 | |||
T3753 |
Sinapinic Acid
Sinapic acid,芥子酸,Synapoic acid |
Apoptosis; RAAS; Reactive Oxygen Species; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB |
Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类,是HDAC 抑制剂,对ACE-I 的活性也有抑制作用。它有抗肿瘤活性,诱导肿瘤细胞凋亡,具有抗氧化、抗糖尿病的作用。 | |||
T6S1369 |
Vitexin
牡荆素,Apigenin-8-C-glucoside |
Antioxidant | oxidation-reduction |
Vitexin 是一种存在于多种药用植物(如榕树、螺旋藻)中的 c-糖基化的黄酮。 它具有广泛的药理作用,包括抗氧化,抗癌,抗炎,抗痛觉过敏和神经保护作用。 | |||
T3893 |
Forsythoside B
连翘酯苷 B,连翘脂苷B |
TNF; NF-κB | Apoptosis; NF-κB |
Forsythoside B 是传统中药植物独一味叶子中分离的一种苯乙醇苷。它可抑制 TNF-alpha,IL-6,IκB, 调节 NF-κB。它抑制炎症反应,具有抗氧化和神经保护作用。 | |||
T5S0053 |
Coptisine
黄连碱,Coptisin |
Indoleamine 2,3-Dioxygenase (IDO) | Metabolism |
Coptisine (Coptisin) 是一种从黄连中分离到的生物碱,是非竞争性的IDO 抑制剂,Ki=为 5.8 μM,IC50=6.3 μM。 | |||
T13576 |
β-cyano-L-Alanine
Beta-cyano-l-alanine |
Others | Others |
β-cyano-L-Alanine (Beta-cyano-l-alanine) 是广泛存在于高等植物中的腈,氰基丙氨酸合成酶以氰化物和半胱氨酸作为底物反应产生。它消除了乙醇对脑缺血/再灌注 (I/R) 损伤的保护作用。 | |||
T4S2326 |
Cornuside
7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside |
ERK; p38 MAPK; NF-κB; JNK | MAPK; NF-κB |
Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷,可用于炎症疾病的研究和促进血液循环。 它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应,用于炎性过敏性疾病中的潜能。 | |||
T3895 |
Polyphyllin I
重楼皂苷I,重楼皂甙 |
Apoptosis; Akt; JNK; PDK; mTOR; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Polyphyllin I 是从七叶一枝花中提取的生物活性成分,具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂,也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬,G2/M 期阻滞和细胞凋亡。 | |||
T40576 |
(S)-Salsolidine
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(S)-Salsolidine, a chemical compound, functions as a weak inhibitor of monoamine oxidase (MAO), exhibiting an inhibition constant (K i ) of 63 μM. R enantiomer demonstrating a greater efficacy than (S)-Salsolidine, boasting a K i value of 26 μM compared to the S form. | |||
TN3914 | Echinatine | ATPase; IL Receptor; TNF | Apoptosis; Immunology/Inflammation; Membrane transporter/Ion channel |
Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin can inhibit DNP-ATPase activity whil | |||
T19169 |
9-cis-Retinal
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Others | Others |
9-cis-Retinal is a natural retinoid. Dietary 9-cis-β-carotene generates 9-cis-retinoids via cleavage into 9-cis-retinal. 9-cis Retinal binds to CRBP-I and CRBP-II (Kds: 8 nM and 5 nM). It expedites differentiation and maturation of rod photoreceptors in r | |||
T36000 |
3-Hydroxyterphenyllin
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3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methi... |