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Search Results for " cot "

Targets Recommended: Na-K-Cl cotransporter TNF MAPK

136

抑制剂 & 化合物

37

天然产物

12

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10865L	Cot inhibitor-1 hydrochloride Cot inhibitor-1 hydrochloride(915365-57-0 Free base)	TNF; MAPK	Apoptosis; MAPK
	Cot inhibitor-1 hydrochloride 是肿瘤进展位点 2 激酶 (IC50 = 28 nM) 的抑制剂，可抑制人全血中 TNF-α 的产生 (IC50 = 5.7 nM)。
T10865	Cot inhibitor-1	TNF; MAPK	Apoptosis; MAPK
	Cot inhibitor-1 是一种选择性的 Cot 蛋白激酶(也被称为 Tpl2或 MAP3K8)抑制剂(IC50 为 28 nM)。Cot inhibitor-1 抑制人全血中 TNF-alpha 的产生，其 IC50 为 5.7 nM。Cot 参与多种细胞信号通路，特别是与炎症和免疫反应有关的信号通路。Cot inhibitor-1抑制 Cot 活性，可能对类风湿关节炎、炎症性肠病和某些类型的癌症具有潜在的治疗效果。
T10866	Cot inhibitor-2	TNF; MAPK	Apoptosis; MAPK
	Cot inhibitor-2 是一种 cot (Tpl2/MAP3K8) 抑制剂(IC50 : 1.6 nM)，具有有效性，选择性和口服活性。Cot inhibitor-2 对LPS 刺激的人全血中 TNF-α 的产生具有抑制作用，IC50 为 0.3 μM。
T22459	Xanthinol Nicotinate Angioamin,烟酸占替诺,Complamin	Others	Others
	Xanthinol Nicotinate (Complamin) 是血管扩张剂，可直接作用于小动脉和毛细血管的平滑肌，能够扩大血管，改善血液流变学并降低外周血管阻力。
T76883	Talacotuzumab CSL 362,JNJ 56022473	Immunology/Inflammation related; Interleukin	Immunology/Inflammation
	Talacotuzumab (JNJ 56022473) 是一种含有修饰的 Fc 结构的IgG1 型完全人源化的 CD123 中和单克隆抗体。Talacotuzumab 对 CD123、CD32b/c、CD16-158F、CD16-158V 具有很高的亲和力， KD 分别为 0.43 nM、188 nM、46 nM、16.8 nM。Talacotuzumab 通过抑制 IL-3 与 CD123 结合进而抑制靶细胞中的 IL-3 信号传导。Talacotuzumab 诱导 Fc 区发生突变以增加对 CD16 (FcγRIIIa) 的亲和力，从而加强抗体依赖性细胞介导的细胞毒性 (ADCC)。Talacotuzumab 急性髓性白血病 (AML) 异种移植小鼠模型中抑制白血病细胞生长。
T40042	Evifacotrep	TRP/TRPV Channel	Membrane transporter/Ion channel
	Evfacotrep 是一种有效的短期瞬态受体电位通道5 拮抗剂。Evfacotrep 可用于神经系统疾病的研究。
T0067	Nicotinic acid N-oxide 烟酸-N-氧化物,Nicotinic acid 1-oxide,氧烟酸,Oxiniacic Acid	Others	Others
	Nicotinic acid N-oxide (Nicotinic acid 1-oxide) 是一种烟酸衍生物，用于治疗高脂血症。
T77676	(Z)-Metanicotine 2HCl (Z)-Metanicotine 2HCl(1129-68-6 Free base)	Others	Others
	(Z)-Metanicotine 2HCl 具有镇痛活性，可用于治疗中枢系统疾病。
TP1244L1	Adrenocorticotropic Hormone (ACTH) (1-10), human acetate Adrenocorticotropic Hormone (ACTH) (1-10), human acetate(2791-05-1 Free base)	Others	Others
	Adrenocorticotropic Hormone (ACTH) (1-10), human acetate 是促肾上腺皮质激素的一个片段。 Adrenocorticotropic Hormone (ACTH) (1-10), human acetate 仅在 100 和 1000 nM 时具有较弱的 α-MSH 效力。
T15199	Edicotinib JNJ-527,JNJ-40346527	c-Fms; FLT; CSF-1R; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Edicotinib (JNJ-527) 是能够透过血脑屏障的、口服具有活性的、选择性的CSF-1R 抑制剂 (IC50:3.2 nM)。它对 KIT (IC50:20 nM) 和 FLT3 (IC50:190 nM) 的抑制作用较小。它抑制小胶质细胞的扩张，减弱小胶质细胞的增殖和神经退行性变。它可用于研究阿尔茨海默病和类风湿性关节炎。
T31195	Dalcotidine KU 1257,KU-1257	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Dalcotidine (KU 1257) 是一种新型组胺H2受体拮抗剂，具有组胺H9受体拮抗活性和抗分泌作用，与豚鼠大脑皮层结合的Ki 值为0.040 对分离性豚鼠右心房组胺诱导的正变时反应的拮抗作用的KB 值为0.041。Dalcotidine 提高了溃疡愈合的质量，可能有助于降低溃疡的复发率和复发率。
T38654	Cotosudil	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Cotosudil 是一种 ROCK 激酶抑制剂，具有抗高血压活性，可用于治疗或预防白内障、心血管疾病或神经退行性疾病或神经损伤引起的疾病或病症。
T0548	Methyl 5-methylnicotinate	Others	Others
	Methyl 5-methylnicotinate 用作医药中间体。
T20366	beta-Nicotyrine bata-碱二烯,Nicotyrine,alpha-Nicotyrine	Others	Others
	beta-Nicotyrine 是一种 Nicotine 的代谢物。它是一种微量的烟草生物碱，提取自普通烟草植物的叶子和香烟烟雾冷凝物。
T0552	Isonicotinamide	Others	Others
	Isonicotinamide 用作医药中间体，用于合成头孢氯铵等。
T16951	Sulcotrione	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Sulcotrione 属于β-三酮类除草剂，对羟基苯基丙酮酸双加氧酶有抑制作用。
T20444	Hexyl nicotinate AI3 15769,AI3-15769,烟酸己酯,AI315769	Others	Others
	Hexyl nicotinate (AI3 15769) 是一种皮肤血管扩张剂，可用于研究头皮、面部和背部的非免疫性接触性荨麻疹。
T7545	6-Aminonicotinamide	Others	Others
	6-Aminonicotinamide 是一种竞争性 NADP+依赖性酶，是一种烟酰胺抗代谢药，葡萄糖 6-磷酸脱氢酶抑制剂 (Ki=0.46 μM)。它干扰糖酵解，导致 ATP 耗竭，并与 DNA 交联化学疗法药物，如Cisplatin，协同杀死癌细胞。
T2319	Acotiamide monohydrochloride trihydrate Acotiamide hydrochloride,YM-443 HCl,盐酸阿考替胺,Z-338 HCl	AChE	Neuroscience
	Acotiamide monohydrochloride trihydrate (Z-338 HCl) 是一种首创的、具有口服活性的胃肠动力药。它通过促毒蕈碱受体拮抗作用和乙酰胆碱酯酶(AChE)抑制作用增强肠神经元释放的乙酰胆碱，从而增强胃排空和胃部适应性，有潜力用于功能性消化不良的研究。
T0664	Nicotinic acid hydrazide	Others	Others
	Nicotinic acid hydrazide（NAH）是烟酸的酰肼衍生物，一种杂环有机物，是过氧化物酶抑制剂，可以形成具有较强生物活性的固态金属配合物。
T4509	Inositol nicotinate Inositol niacinate,Hexanicotol,Myo-Inositol hexanicotinate,Mesotal,肌醇烟酸酯,Dilexpal,Inositol hexanicotinate	Others	Others
	Inositol nicotinate (Mesotal) 是一种血管扩张剂，可用于研究外周动脉疾病。
T5314	pyridoxal isonicotinoyl hydrazone 吡哆醛异烟酰肼,PIH	Others	Others
	pyridoxal isonicotinoyl hydrazone (PIH) 是亲脂的三价铁螯合剂，具有高铁螯合特性。
T24533	Nicotinoyl azide N-Az,NAz,叠氮烟酸甲酰,N Az	Others	Others
	Nicotinoyl azide (N-Az) 是一种光活化化学探针。它已被用于测量嘌呤核碱基的溶剂可及性。
T40377	Nicotredole Tryptamide,尼可曲多；尼可曲朵	Others	Others
	Nicotredole (Tryptamide) 是一种口服有效的消炎剂，与 Phenylbutazone 的抗炎作用相当。它仅具有弱的致溃疡活性。它可用于缓解疼痛方面的研究。
T8231	Adrenocorticotropic Hormone (ACTH) (1-39), human ACTH (1-39), human,丝拉克肽	Others	Others
	Adrenocorticotropic Hormone (ACTH) (1-39), human (ACTH (1-39), human) 是黑皮质素受体激动剂。
T77443	Racotumomab	Others	Others
	Racotumomab (Anti-Human NGcGM3 Recombinant Antibody) 是一种小鼠 γ 型抗独特型单克隆抗体，可特异性诱导针对在多种实体瘤中过表达的 Neu-glycolyl GM3 神经节苷脂（NeuGcGM3）的抗体反应。Racotumomab 可与含有 Neu-glycolyl (NeuGc) 的神经节苷脂、硫苷脂和肿瘤中表达的其他抗原发生反应。Racotumomab 具有抗癌活性，可用于肺癌的研究。
T22348	Isonipecotic acid 4-Piperidinecarboxylic acid,Hexahydroisonicotinic acid,4-哌啶甲酸,4-Carboxypiperidine	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Isonipecotic acid (4-Piperidinecarboxylic acid) 是一种杂环化合物。它主要表征为 GABAA 受体部分激动剂。
T79157	Pimicotinib ABSK021,ABSK-021	c-Fms; Others	Others; Tyrosine Kinase/Adaptors
	Pimicotinib (ABSK021) 为一种有效的 CSF1R 抑制剂，具抗肿瘤活性，可用于研究晚期实体瘤。
T4325	COTI-2 COTI 2,COTI2	Apoptosis; p53	Apoptosis
	COTI-2是一种具有口服活性的低毒性抗癌药物，是 p53 突变体激活剂。它通过激活突变型 p53 和抑制PI3K/AKT/mTOR 途径发挥作用，通过 p53 依赖和非依赖机制在 HNSCC 中具有抗肿瘤活性。它诱导多种人肿瘤细胞凋亡，可将突变型 p53 转化为野生型构象。
T6153	Icotinib BPI-2009,埃克替尼,BPI-2009H,Conmana	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Icotinib (Conmana) 是一种口服的基于喹唑啉的表皮生长因子受体 (EGFR) 抑制剂，IC50值为5 nM，具有潜在的抗肿瘤活性。
TP1144L	Corticotropin-releasing factor (human) acetate Corticotropin-releasing factor (human) acetate (86784-80-7 Free base)	CRFR	GPCR/G Protein
	Corticotropin-releasing factor (human) acetate 刺激垂体前叶合成和分泌促肾上腺皮质激素。
T9735	6-(4-methylpiperazin-1-yl)-4-o-tolylnicotinamide	Others	Others
	6-(4-methylpiperazin-1-yl)-4-o-tolylnicotinamide 可用于合成befetupitant 和netupitant。
T3357	Clascoterone Cortexolone 17 alpha-propionate,17 alpha-propionate,21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮,CB-03-01,Cortexolone 17α-propionate	Androgen Receptor	Endocrinology/Hormones
	Clascoterone (CB-03-01) 是一种新型的局部和外周的雄性激素拮抗剂。
T7627L	Adrenocorticotropic Hormone (ACTH) (4-10) TFA Adrenocorticotropic Hormone (ACTH) (4-10) TFA(4037-01-8(free base)),Acth (4-10)	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	Adrenocorticotropic Hormone (ACTH) (4-10) TFA (Acth (4-10)) 是一种有效的黑皮质素 (MC4R) 受体激动剂。
T7869	N-(Hydroxymethyl)nicotinamide Nicoform,N-hydroxymethylnicotinamide,Bilamid,N-羟甲基烟酰胺,Nikomethamide,N-(Hytroxymethy)micotinamide	Anti-infection; Antibacterial	Microbiology/Virology
	N-(Hydroxymethyl)nicotinamide (Bilamid) 是一种抗微生物剂。
TP1240	Adrenocorticotropic Hormone (ACTH) (18-39), human TFA CLIP (human) (TFA)	Others	Others
	Adrenocorticotropic Hormone (ACTH) (18-39), human TFA (CLIP human TFA) 是一种似皮质促素中叶肽，由垂体中叶的促黑素细胞产生。
TP1103	Cotadutide acetate MEDI0382 acetate,Cotadutide acetate (1686108-82-6 Free base)	Glucagon Receptor	GPCR/G Protein
	Cotadutide acetate (MEDI0382 acetate) 是一种有效的胰高血糖素样肽-1 (GLP-1) 和胰高血糖素受体肽双重激动剂，EC50 分别为 6.9 pM 和 10.2 pM。
T9153	Picotamide	Others	Others
	Picotamide 具有抗凝和纤维蛋白溶解特性。
T1365	Thioisonicotinamide Pyridine-4-carbothioamide,Isothionicotinamide,硫代异烟酰胺,4-Pyridylthiocarboxamide	Antibiotic	Microbiology/Virology
	Thioisonicotinamide (Isothionicotinamide) 是一种可用于药物合成的合成中间体。
T2307	Icotinib Hydrochloride 埃克替尼盐酸盐,盐酸埃克替尼,BPI-2009H	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Icotinib Hydrochloride (BPI-2009H) 是一种口服的基于喹唑啉的表皮生长因子受体 (EGFR) 抑制剂，IC50值为5 nM，具有潜在的抗肿瘤活性。
T7713	Benzyl nicotinate 烟酸苄酯,Rubriment,Pycaril	GPR	Endocrinology/Hormones; GPCR/G Protein
	Benzyl nicotinate (Pycaril) 是血管扩张剂，可用于引起充血的一种活性成分。
T19438	Myristyl nicotinate Tetradecyl nicotinate,肉豆蔻醇烟酸酯	GPR	Endocrinology/Hormones; GPCR/G Protein
	Myristyl nicotinate (Tetradecyl nicotinate) 是 Nicotinic acid 的亲脂衍生物，是一种酯前药。它能够刺激光损伤的皮肤中的表皮分化，增加皮肤 NAD 含量并增强人皮肤屏障。它被开发用于将烟酸输送到皮肤中，以防止光化性角化病及其发展为皮肤癌。
T63237	Acotiamide hydrochloride
	Acotiamide hydrochloride 是选择性的、口服具有活力的、可逆的乙酰胆酶碱酯 (AChE) 抑制剂 (IC50: 1.79 μM)，能够提高胃收缩性，加速胃排空延迟，能够用于研究胃动力障碍的功能性消化不良及肠道炎症。
T34017	Phenyl nicotinate NSC75878,NSC 75878,NSC-75878
	Phenyl nicotinate is a biochemical.
T69804	Nicotine monomethiodide
	Nicotine monomethiodide is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
T68819	Icotidine hydrochloride
	Icotidine hydrochloride is an antagonist of histamine at both H1 and H2 receptors.
T125939	Ascotrichic acid
	Ascotrichic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125939，CAS号为 1393815-37-6。
T40059	Nicotinamide riboside tartrate
	Nicotinamide riboside tartrate (NRT) is an oral NAD+ precursor that raises NAD+ levels, activates SIRT1 and SIRT3, and serves as a vitamin B3 (niacin) source. NRT also improves oxidative metabolism and protects against metabolic abnormalities induced by a high-fat diet. Furthermore, NRT mitigates cognitive decline in a transgenic mouse model of Alzheimer's disease.
T73663	Adrenocorticotropic hormone
	Adrenocorticotropic hormone (ACTH) 是一种由垂体前叶分泌的促肾上腺皮质激素(tropic hormone)，能够调节皮质醇和雄激素的产生。
T75309	R-(+)-Cotinine
	R-(+)-Cotinine ((+)-Cotinine) 是一种尼古丁代谢物，在广泛的药理靶标中缺乏显着活性。R-(+)-Cotinine 可以增强人 α7nAChR 中的 Ach 诱发电流。

化合物

Cot inhibitor-1 hydrochloride

Cat.No: T10865L

Synonym: Cot inhibitor-1 hydrochloride(915365-57-0 Free base)

Target: TNF, MAPK

Cot inhibitor-1

Cat.No: T10865

Target: TNF, MAPK

Cot inhibitor-2

Cat.No: T10866

Target: TNF, MAPK

Xanthinol Nicotinate

Cat.No: T22459

Synonym: Angioamin,烟酸占替诺,Complamin

Target: Others

Cat.No: T76883

Synonym: CSL 362,JNJ 56022473

Target: Immunology/Inflammation related, Interleukin

Cat.No: T40042

Target: TRP/TRPV Channel

Nicotinic acid N-oxide

Cat.No: T0067

Synonym: 烟酸-N-氧化物,Nicotinic acid 1-oxide,氧烟酸,Oxiniacic Acid

Target: Others

(Z)-Metanicotine 2HCl

Cat.No: T77676

Synonym: (Z)-Metanicotine 2HCl(1129-68-6 Free base)

Target: Others

Adrenocorticotropic Hormone (ACTH) (1-10), human acetate

Cat.No: TP1244L1

Synonym: Adrenocorticotropic Hormone (ACTH) (1-10), human acetate(2791-05-1 Free base)

Target: Others

Cat.No: T15199

Synonym: JNJ-527,JNJ-40346527

Target: c-Fms, FLT, CSF-1R, c-Kit

Cat.No: T31195

Synonym: KU 1257,KU-1257

Target: Histamine Receptor

Cat.No: T38654

Target: ROCK

Methyl 5-methylnicotinate

Cat.No: T0548

Target: Others

beta-Nicotyrine

Cat.No: T20366

Synonym: bata-碱二烯,Nicotyrine,alpha-Nicotyrine

Target: Others

Isonicotinamide

Cat.No: T0552

Target: Others

Cat.No: T16951

Target: Reactive Oxygen Species

Hexyl nicotinate

Cat.No: T20444

Synonym: AI3 15769,AI3-15769,烟酸己酯,AI315769

Target: Others

6-Aminonicotinamide

Cat.No: T7545

Target: Others

Acotiamide monohydrochloride trihydrate

Cat.No: T2319

Synonym: Acotiamide hydrochloride,YM-443 HCl,盐酸阿考替胺,Z-338 HCl

Target: AChE

Nicotinic acid hydrazide

Cat.No: T0664

Target: Others

Inositol nicotinate

Cat.No: T4509

Synonym: Inositol niacinate,Hexanicotol,Myo-Inositol hexanicotinate,Mesotal,肌醇烟酸酯,Dilexpal,Inositol hexanicotinate

Target: Others

pyridoxal isonicotinoyl hydrazone

Cat.No: T5314

Synonym: 吡哆醛异烟酰肼,PIH

Target: Others

Nicotinoyl azide

Cat.No: T24533

Synonym: N-Az,NAz,叠氮烟酸甲酰,N Az

Target: Others

Cat.No: T40377

Synonym: Tryptamide,尼可曲多；尼可曲朵

Target: Others

Adrenocorticotropic Hormone (ACTH) (1-39), human

Cat.No: T8231

Synonym: ACTH (1-39), human,丝拉克肽

Target: Others

Cat.No: T77443

Target: Others

Isonipecotic acid

Cat.No: T22348

Synonym: 4-Piperidinecarboxylic acid,Hexahydroisonicotinic acid,4-哌啶甲酸,4-Carboxypiperidine

Target: GABA Receptor

Cat.No: T79157

Synonym: ABSK021,ABSK-021

Target: c-Fms, Others

Cat.No: T4325

Synonym: COTI 2,COTI2

Target: Apoptosis, p53

Cat.No: T6153

Synonym: BPI-2009,埃克替尼,BPI-2009H,Conmana

Target: EGFR

Corticotropin-releasing factor (human) acetate

Cat.No: TP1144L

Synonym: Corticotropin-releasing factor (human) acetate (86784-80-7 Free base)

Target: CRFR

6-(4-methylpiperazin-1-yl)-4-o-tolylnicotinamide

Cat.No: T9735

Target: Others

Cat.No: T3357

Synonym: Cortexolone 17 alpha-propionate,17 alpha-propionate,21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮,CB-03-01,Cortexolone 17α-propionate

Target: Androgen Receptor

Adrenocorticotropic Hormone (ACTH) (4-10) TFA

Cat.No: T7627L

Synonym: Adrenocorticotropic Hormone (ACTH) (4-10) TFA(4037-01-8(free base)),Acth (4-10)

Target: Melanocortin Receptor

N-(Hydroxymethyl)nicotinamide

Cat.No: T7869

Synonym: Nicoform,N-hydroxymethylnicotinamide,Bilamid,N-羟甲基烟酰胺,Nikomethamide,N-(Hytroxymethy)micotinamide

Target: Anti-infection, Antibacterial

Adrenocorticotropic Hormone (ACTH) (18-39), human TFA

Cat.No: TP1240

Synonym: CLIP (human) (TFA)

Target: Others

Cotadutide acetate

Cat.No: TP1103

Synonym: MEDI0382 acetate,Cotadutide acetate (1686108-82-6 Free base)

Target: Glucagon Receptor

Cat.No: T9153

Target: Others

Thioisonicotinamide

Cat.No: T1365

Synonym: Pyridine-4-carbothioamide,Isothionicotinamide,硫代异烟酰胺,4-Pyridylthiocarboxamide

Target: Antibiotic

Icotinib Hydrochloride

Cat.No: T2307

Synonym: 埃克替尼盐酸盐,盐酸埃克替尼,BPI-2009H

Target: EGFR

Benzyl nicotinate

Cat.No: T7713

Synonym: 烟酸苄酯,Rubriment,Pycaril

Target: GPR

Myristyl nicotinate

Cat.No: T19438

Synonym: Tetradecyl nicotinate,肉豆蔻醇烟酸酯

Target: GPR

Acotiamide hydrochloride

Cat.No: T63237

Phenyl nicotinate

Cat.No: T34017

Synonym: NSC75878,NSC 75878,NSC-75878

Nicotine monomethiodide

Cat.No: T69804

Icotidine hydrochloride

Cat.No: T68819

Ascotrichic acid

Cat.No: T125939

Nicotinamide riboside tartrate

Cat.No: T40059

Adrenocorticotropic hormone

Cat.No: T73663

R-(+)-Cotinine

Cat.No: T75309

Cat. No.	Product Name	Target	Signaling Pathways
T9352	hydrocotarnine	Others	Others
	hydrocotarnine 是 Cbl 的抑制剂。
T19768	γ-Tocotrienol gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol,γ-生育三烯酚	Others	Others
	γ-Tocotrienol (Plastochromanol) 是一种维生素 E 的活性形式。
T4721	β-Nicotinamide mononucleotide β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸	Others; Endogenous Metabolite	Metabolism; Others
	β-Nicotinamide mononucleotide (β-NM) 是烟酰胺磷酸核糖转移酶 (NAMPT) 反应的产物。β-nicotinamide mononucleotide 的作用包括其在细胞生化功能、心脏保护、糖尿病、肥胖相关并发症和阿尔茨海默病中的作用。
T7919	6-Aminonicotinic acid	Others	Others
	6-Aminonicotinic acid 是一种天然产物。
T66582	6-Methylnicotinamide	Endogenous Metabolite	Metabolism
	6-Methylnicotinamide 是烟酰胺的衍生物，是一种内源性代谢物。在脑出血 (ICH) 急性期， 6-Methylnicotinamide 突然增加会加剧神经损伤。6-Methylnicotinamide 可用于制作共晶体/盐。
TMA2474	δ-Tocotrienol Delta-Tocotrienol,δ-生育三烯酚	ERK; BCL; VEGFR; Akt; PI3K; PDK; p53	Angiogenesis; Apoptosis; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	δ-Tocotrienol (Delta-Tocotrienol) 是一种维生素 E，存在于蔬菜，水果，种子，坚果，谷物和油等。维生素 E 是抗氧化剂、神经保护剂和抗癌剂，可以降低胆固醇和其他脂质，保护心血管疾病。
T5562	Methyl nicotinate 烟酸甲酯,methyl pyridine-3-carboxylate	Others	Others
	Methyl nicotinate (methyl pyridine-3-carboxylate) 是一种盐酸甲酯，发现于酒精饮料中，在非处方局部制剂中用作活性成分，用于研究肌肉和关节疼痛。
T6S1294	Nicotiflorin Nictoflorin,Kaempferol-3-O-Rutinoside,山奈酚-3-O-芸香糖苷,Nicotifloroside	Others	Others
	Nicotiflorin (Kaempferol-3-O-Rutinoside) 是一种黄酮苷，从传统中药Flos Carthami 中提取得到。它有抗糖化活性和神经保护作用。
T8166	Pennogenin 3-O-beta-chacotrioside 偏诺皂苷元-3-O-Α-L-吡喃鼠李糖-(1→4)[Α-L-吡喃鼠李糖基](1→2)-Β-D-葡萄糖苷	Autophagy	Autophagy
	Pennogenin 3-O-beta-chacotrioside 是从七叶一枝花中分离得到的一种天然产物，具有抗结肠癌活性。它可以调节自噬，增加自噬相关蛋白 LC3 和 Beclin-1 的表达。
T4816	6-Hydroxynicotinic acid 6-Hydroxypyridine-3-carboxylic acid,6-羟基烟酸,2-Hydroxy-5-pyridinecarboxylic acid	Others; Endogenous Metabolite	Metabolism; Others
	6-Hydroxynicotinic acid (6-Hydroxypyridine-3-carboxylic acid) 用于核磁共振波谱或气相色谱-质谱法诊断尿路感染中的铜绿假单胞菌。在引起尿液感染的常见细菌中，只有铜绿假单胞菌从烟酸中产生6-羟基烟酸。
T5228	Nicotinuric acid	Others; Endogenous Metabolite	Metabolism; Others
	Nicotinuric acid 是一种酰基甘氨酸，通常是脂肪酸的次要代谢物。酰基甘氨酸是通过甘氨酸 N-酰基转移酶的作用产生的。
T1202	Cotinine (-)-Cotinine,S-(-)-Cotinine,(S)-Cotinine,NIH-10498,可替宁	Endogenous Metabolite; AChR	Metabolism; Neuroscience
	Cotinine (NIH-10498) 是烟草中的生物碱, 也是尼古丁的主要代谢物。Cotinine (NIH-10498) 是测量烟草烟雾成分的生物指标。
Fr13756	Isonicotinic acid	Endogenous Metabolite; Drug Metabolite	Metabolism
	Isonicotinic acid 是 Isoniazid 的代谢产物。Isoniazid 通过肼解转化为 Isonicotinic acid。 Isoniazid 向 Isonicotinic acid 的生物转化可以通过细胞色素 P450 酶催化。
T5233	N-Methylnicotinamide N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide,N-甲基烟酰胺	Others; Endogenous Metabolite	Metabolism; Others
	N-Methylnicotinamide (Nicotinic Acid Methylamide) 是内源性代谢产物的一种。
T6220	Nicotinamide riboside chloride 烟酰胺核糖氯酸盐,烟酰胺核苷	Sirtuin; Endogenous Metabolite	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Nicotinamide riboside Chloride 是维生素 B3 的来源，可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。它是具有口服活性的 NAD+的前体，增加 NAD+水平并激活SIRT1和SIRT3，可用于研究阿尔茨海默氏病的认知退化。
T9675	α-Tocotrienol	Endogenous Metabolite	Metabolism
	α-Tocotrienol 是维生素 E 的一种亚型，存在于蔬菜、水果、种子、坚果、谷物和油脂中。α-Tocotrienol 是抗氧化剂，可以降低胆固醇和其他脂类，也是神经保护和抗癌剂，在心血管疾病的保护中发挥作用。
T13795	Nicotinamide riboside	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Nicotinamide riboside 是维生素 B3 的来源，可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。它是具有口服活性的 NAD+的前体，增加 NAD+水平并激活SIRT1和SIRT3，可用于研究阿尔茨海默氏病的认知退化。
T13626	Cottonseed oil	Others	Others
	Cottonseed oil 是一种提取自棉花种子中的食用油，是一种植物油中杀虫能力极强的油。
TN1698	Glucotropaeolin potassium 金莲葡糖硫苷钾盐,Glucotropaeolin,Benzylglucosinolate potassium,Glucotropaeolin Potassium Salt	Others	Others
	Glucotropaeolin potassium (Benzylglucosinolate potassium) 存在于十字花科蔬菜中，并且可适度减少动物的自发性DNA 损伤。
TN1528	Cotoin	AChE	Neuroscience
	Cotoin 是从 Garcinia virgate 茎皮中分离出的一种天然产物。Cotoin 具有解痉活性，可降低孤立的兔肠的音调和收缩。它部分抑制乙酰胆碱、毛果芸香碱和 BaCl 对分离肠的影响。
T0617	Nicotinamide N-oxide Nicotinamide-N-oxide,Nicotinamide 1-oxide,N-氧代烟酰胺,烟酰胺-N-氧化物,1-oxynicotinamide	c-Myc; Endogenous Metabolite; CXCR; Drug Metabolite	Autophagy; Cell Cycle/Checkpoint; GPCR/G Protein; Immunology/Inflammation; Metabolism
	Nicotinamide N-oxide (Nicotinamide 1-oxide) 是生物体内烟酰胺分解代谢物，是高效选择性CXCR2受体拮抗剂。
TN6365	3-Deoxy-11,13-dihydroisosecotanapartholide
	3-Deoxy-11,13-dihydroisosecotanapartholide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6365，CAS号为 572924-43-7。
TN1220	20(S),24(R)-Ocotillol	Others	Others
	20(S),24(R)-Ocotillol is a natural product
TN1323	6-O-Nicotinoylbarbatin C 6-O-烟酰半枝莲素 C	Others	Others
	6-O-Nicotinoylbarbatin C is a natural product
TN5930	Ocotillone
	Ocotillone has potent antibacterial activity against Gram-negative bacteria, P. aeruginosa and S. typhimurium, that are without hemolytic activity, whereas it has weak antimicrobial activity against Gram-positive bacteria and fungi. Ocotillone shows only
T78481	Lactodifucotetraose 2′,3-Difucosyllactose,Difucosyllactose
	Lactodifucotetraose (Difucosyllactose)，一种四糖，源自人乳。该分子包括D-葡萄糖，D-半乳糖及L-fucose。
T21523	β-Tocotrienol Beta-Tocotrienol	Caspase	Apoptosis; Proteases/Proteasome
	Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers. It inhibits the growth of both A549 (GI50=1.38±0.334μM) and U87MG (GI50=2.53±0.604μM) cells at rather low concentrations.
T19361	Hydroxycotinine	Others	Others
	Hydroxycotinine is the main nicotine metabolite detected in smokers' urine.
TN2890	3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one	Trk receptor	Tyrosine Kinase/Adaptors
	3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one是一种天然产物，属于大戟科大戟属，其产品编号为 TN2890，CAS号为 244277-75-6。3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one可用作对照参考。
TN1324	6-O-Nicotinoylscutebarbatine G	Others	Others
	6-O-Nicotinoylscutebarbatine G shows cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC50 values in the range of 2.1 5.7 μM.
TN4655	Nicotine 1'-N-oxide	Others	Others
	Nicotine 1'-N-oxide is a natural product from tobacco smoke.
T36403	Methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate
	Preterramide C is a fungal metabolite that has been found inA. terreus.1It is active againstS. aureus(MIC = 52.4 μM) but notE. aerogenes,P. aeruginosa, orC. albicans(MICs = >100 μM for all).2Preterramide C inhibits the growth of L5178Y mouse lymphoma cells with an IC50value of 0.1 μg/ml.3It also inhibits nitric oxide (NO) production induced by LPS in RAW 264.7 cells (IC50= 5.48 μM).
T19477	Nicotinic acid mononucleotide	Others	Others
	Nicotinic acid mononucleotide is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD+.
TN4237	Hydrocotarnine hydrobromide	Others	Others
	Hydrocotarnine hydrobromide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN4237，CAS号为 5985-00-2。
T67407	Nicotinic acid riboside
	Nicotinic acid riboside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 T67407，CAS号为 17720-18-2。
TN2889	3,4-Secotirucalla-4(28,7,24-triene-3),26-dioic acid	Others	Others
	3,4-Secotirucalla-4(28,7,24-triene-3),26-dioic acid是一种天然产物，属于杨梅科杨梅属，其产品编号为 TN2889，CAS号为 159623-48-0。3,4-Secotirucalla-4(28,7,24-triene-3),26-dioic acid可用作对照参考。
TN1236	3',4',7-Trihydroxyisoflavone	MAPK; JNK	MAPK
	3',4',7-Trihydroxyisoflavone 是大豆异黄酮大豆苷元衍生物，是 Cot (Tpl2/MAP3K8) 和 MKK4 抑制剂，具有抗癌、抗血管生成和自由基清除特性。3',4',7-Trihydroxyisoflavone 通过调节小鼠胆碱能功能和BDNF信号通路增强记忆作用，可改善因内源性或外源性糖皮质激素而受损的皮肤屏障功能，可用于研究特应性皮炎。

天然产物

Cat.No: T9352

Target: Others

Cat.No: T19768

Synonym: gamma Tocotrienol,gammaTocotrienol,gamma-Tocotrienol,D-gamma-Tocotrienol,Plastochromanol,γ-生育三烯酚

Target: Others

β-Nicotinamide mononucleotide

Cat.No: T4721

Synonym: β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸

Target: Others, Endogenous Metabolite

6-Aminonicotinic acid

Cat.No: T7919

Target: Others

6-Methylnicotinamide

Cat.No: T66582

Target: Endogenous Metabolite

Cat.No: TMA2474

Synonym: Delta-Tocotrienol,δ-生育三烯酚

Target: ERK, BCL, VEGFR, Akt, PI3K, PDK, p53

Methyl nicotinate

Cat.No: T5562

Synonym: 烟酸甲酯,methyl pyridine-3-carboxylate

Target: Others

Cat.No: T6S1294

Synonym: Nictoflorin,Kaempferol-3-O-Rutinoside,山奈酚-3-O-芸香糖苷,Nicotifloroside

Target: Others

Pennogenin 3-O-beta-chacotrioside

Cat.No: T8166

Synonym: 偏诺皂苷元-3-O-Α-L-吡喃鼠李糖-(1→4)[Α-L-吡喃鼠李糖基](1→2)-Β-D-葡萄糖苷

Target: Autophagy

6-Hydroxynicotinic acid

Cat.No: T4816

Synonym: 6-Hydroxypyridine-3-carboxylic acid,6-羟基烟酸,2-Hydroxy-5-pyridinecarboxylic acid

Target: Others, Endogenous Metabolite

Nicotinuric acid

Cat.No: T5228

Target: Others, Endogenous Metabolite

Cat.No: T1202

Synonym: (-)-Cotinine,S-(-)-Cotinine,(S)-Cotinine,NIH-10498,可替宁

Target: Endogenous Metabolite, AChR

Isonicotinic acid

Cat.No: Fr13756

Target: Endogenous Metabolite, Drug Metabolite

N-Methylnicotinamide

Cat.No: T5233

Synonym: N'-Methylnicotinamide,Nicotinic Acid Methylamide,N-Methylpyridine-3-carboxamide,N-甲基烟酰胺

Target: Others, Endogenous Metabolite

Nicotinamide riboside chloride

Cat.No: T6220

Synonym: 烟酰胺核糖氯酸盐,烟酰胺核苷

Target: Sirtuin, Endogenous Metabolite

Cat.No: T9675

Target: Endogenous Metabolite

Nicotinamide riboside

Cat.No: T13795

Target: Sirtuin

Cottonseed oil

Cat.No: T13626

Target: Others

Glucotropaeolin potassium

Cat.No: TN1698

Synonym: 金莲葡糖硫苷钾盐,Glucotropaeolin,Benzylglucosinolate potassium,Glucotropaeolin Potassium Salt

Target: Others

Cat.No: TN1528

Target: AChE

Nicotinamide N-oxide

Cat.No: T0617

Synonym: Nicotinamide-N-oxide,Nicotinamide 1-oxide,N-氧代烟酰胺,烟酰胺-N-氧化物,1-oxynicotinamide

Target: c-Myc, Endogenous Metabolite, CXCR, Drug Metabolite

3-Deoxy-11,13-dihydroisosecotanapartholide

Cat.No: TN6365

20(S),24(R)-Ocotillol

Cat.No: TN1220

Target: Others

6-O-Nicotinoylbarbatin C

Cat.No: TN1323

Synonym: 6-O-烟酰半枝莲素 C

Target: Others

Cat.No: TN5930

Lactodifucotetraose

Cat.No: T78481

Synonym: 2′,3-Difucosyllactose,Difucosyllactose

Cat.No: T21523

Synonym: Beta-Tocotrienol

Target: Caspase

Hydroxycotinine

Cat.No: T19361

Target: Others

3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one

Cat.No: TN2890

Target: Trk receptor

6-O-Nicotinoylscutebarbatine G

Cat.No: TN1324

Target: Others

Nicotine 1'-N-oxide

Cat.No: TN4655

Target: Others

Methyl 3,4,5-trimethoxy-2-(2-(nicotinamido)benzamido)benzoate

Cat.No: T36403

Nicotinic acid mononucleotide

Cat.No: T19477

Target: Others

Hydrocotarnine hydrobromide

Cat.No: TN4237

Target: Others

Nicotinic acid riboside

Cat.No: T67407

3,4-Secotirucalla-4(28,7,24-triene-3),26-dioic acid

Cat.No: TN2889

Target: Others

3',4',7-Trihydroxyisoflavone

Cat.No: TN1236

Target: MAPK, JNK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02453	CROT Protein, Human, Recombinant (474 Leu/Val, His) carnitine O-octanoyltransferase,COT	Human	Baculovirus Insect Cells
	Carnitine octanoyltransferase (CROT or COT), also known as octanoyl-CoA: L-carnitine O-octanoyltransferase, medium-chain/long-chain carnitine acyltransferase, and carnitine medium-chain acyltransferase, is a carnitine acyltransferase belonging to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups that catalyzes the reversible transfer of fatty acyl groups between CoA and carnitine. Carnitine octanoyltransferase (CROT or COT) facilitate...
TMPY-04389	MAP3K8 Protein, Human, Recombinant (GST) TPL2,MEKK8,EST,ESTF,COT,Tpl-2,c-COT,AURA2,...	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase 8, also known as Cancer Osaka thyroid oncogene, Proto-oncogene c-Cot, Serine/threonine-protein kinase cot, Tumor progression locus 2 and MAP3K8, is a cytoplasm protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase kinase subfamily. MAP3K8 is expressed in several normal tissues and human tumor-derived cell lines. Isoform 1 of MAP3K8 is activated specifically during the S and G2/M phases of the...
TMPH-03449	Nicotinamidase/PNC1 Protein, S. cerevisiae, Recombinant (His)	Saccharomyces cerevisiae	E. coli
	Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Acts also on nicotinyl hydroxamate. Nicotinamidase/PNC1 Protein, S. cerevisiae, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.0 kDa and the accession number is P53184.
TMPH-00661	Ecotin Protein, E. coli O127:H6, Recombinant (His & Myc) eco,Ecotin	E. coli	E. coli
	General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases.
TMPH-03710	Viscotoxin-A3 Protein, Viscum album, Recombinant (His & SUMO)	Viscum album	E. coli
	Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known. Viscotoxin-A3 Protein, Viscum album, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 20.8 kDa and the accession number is P01538.
TMPH-03060	NaD1 Protein, Nicotiana alata, Recombinant (His & SUMO)	Nicotiana alata	E. coli
	Plant defense peptide with antifungal activity against F.oxysporum and B.cinerea. Retards the growth of the Lepidopteran insect pests H.armigera and H.punctigera.
TMPY-01140	ACOT13/THEM2 Protein, Human, Recombinant (His) THEM2,HT012,ACOT13,PNAS-27,acyl-CoA thioesterase 13	Human	E. coli
	The metabolites of fatty acyl-Coenzyme A (CoA) and metabolic enzymes contribute to lipid biosynthesis, signal transduction, and gene transcription. Members of the acyl-CoA thioesterase (Acot) gene family hydrolyze fatty acyl-CoAs, but their biological functions remain incompletely understood. Thioesterase superfamily member 2 (Them2; synonym Acot13) is enriched in oxidative tissues, associated with mitochondria, and relatively specific for long chain fatty acyl-CoA substrates. Using Them2(-/-) m...
TMPH-03709	Viscotoxin-A3 Protein, Viscum album, Recombinant (His)	Viscum album	P. pastoris (Yeast)
	Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known. Viscotoxin-A3 Protein, Viscum album, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 6.8 kDa and the accession number is P01538.
TMPH-00433	Ex-FABP Protein, Coturnix coturnix japonica, Recombinant (His & Myc)	Coturnix coturnix japonica	E. coli
	Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor. Ex-FABP Protein, Coturnix coturnix japonica, Recombinant (His & Myc) is expr...
TMPH-00434	Ovomucoid Protein, Coturnix delegorguei, Recombinant (His & Myc & SUMO)	Coturnix delegorguei	E. coli
	Ovomucoid Protein, Coturnix delegorguei, Recombinant (His & Myc & SUMO) is expressed in E. coli.
TMPH-03061	Osmotin Protein, Nicotiana tabacum, Recombinant (His & SUMO)	Nicotiana tabacum	E. coli
	Osmotin Protein, Nicotiana tabacum, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 40.3 kDa and the accession number is P14170.
TMPH-03450	Nicotinamidase/PNC1 Protein, S. cerevisiae, Recombinant	Saccharomyces cerevisiae	E. coli
	Catalyzes the deamidation of nicotinamide, an early step in the NAD(+) salvage pathway. Positively regulates SIR2-mediated silencing and longevity by preventing the accumulation of intracellular nicotinamide, an inhibitor of SIR2, during times of stress. Acts also on nicotinyl hydroxamate. Nicotinamidase/PNC1 Protein, S. cerevisiae, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 25.0 kDa and the accession number is P53184.

重组蛋白

CROT Protein, Human, Recombinant (474 Leu/Val, His)

Cat.No: TMPY-02453

Species: Human

Expression System: Baculovirus Insect Cells

MAP3K8 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04389

Species: Human

Expression System: Baculovirus Insect Cells

Nicotinamidase/PNC1 Protein, S. cerevisiae, Recombinant (His)

Cat.No: TMPH-03449

Species: Saccharomyces cerevisiae

Expression System: E. coli

Ecotin Protein, E. coli O127:H6, Recombinant (His & Myc)

Cat.No: TMPH-00661

Species: E. coli

Expression System: E. coli

Viscotoxin-A3 Protein, Viscum album, Recombinant (His & SUMO)

Cat.No: TMPH-03710

Species: Viscum album

Expression System: E. coli

NaD1 Protein, Nicotiana alata, Recombinant (His & SUMO)

Cat.No: TMPH-03060

Species: Nicotiana alata

Expression System: E. coli

ACOT13/THEM2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01140

Species: Human

Expression System: E. coli

Viscotoxin-A3 Protein, Viscum album, Recombinant (His)

Cat.No: TMPH-03709

Species: Viscum album

Expression System: P. pastoris (Yeast)

Ex-FABP Protein, Coturnix coturnix japonica, Recombinant (His & Myc)

Cat.No: TMPH-00433

Species: Coturnix coturnix japonica

Expression System: E. coli

Ovomucoid Protein, Coturnix delegorguei, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00434

Species: Coturnix delegorguei

Expression System: E. coli

Osmotin Protein, Nicotiana tabacum, Recombinant (His & SUMO)

Cat.No: TMPH-03061

Species: Nicotiana tabacum

Expression System: E. coli

Nicotinamidase/PNC1 Protein, S. cerevisiae, Recombinant

Cat.No: TMPH-03450

Species: Saccharomyces cerevisiae

Expression System: E. coli

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