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Search Results for " melanin "

44

抑制剂 & 化合物

53

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1104L	Melanin Concentrating Hormone, salmon acetate MCH (salmon),Melanin Concentrating Hormone, salmon acetate(87218-84-6 free base)	Others; Melanin-concentrating Hormone Receptor (MCHR)	GPCR/G Protein; Others
	Melanin Concentrating Hormone, salmon acetate (MCH (salmon))(87218-84-6 free base) 是一种 19 个氨基酸的环状肽，主要在下丘脑中表达。
T38855	Melanin probe-1
	Melanin probe-1, an 18F-picolinamide-based PET probe, is utilized for PET imaging of malignant melanoma. It demonstrates remarkable tumor targeting efficacy, superior tumor imaging contrasts, favorable biodistribution profiles, and robust in vivo stability.
TP1104	Melanin Concentrating Hormone, salmon MCH (salmon)
	Melanin Concentrating Hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus.
T64640	Melanin probe-2
	Melanoma is a lethal skin cancer. The early detection of melanoma using positron emission tomography (PET) probes is critical for improving the survival of melanoma patients. Melanin probe-2 is a non-radioactive bromo-picolinamide precursor that has been used for the synthesis of18F-picolinamides based PET probe (melanin probe-1). The tumor-targeting efficacy and imaging property of three melanin probes were evaluated in B16F10 tumor-bearing mice.18F-1 and18F-3 had much lower tumor uptake compar...
T75970	Melanin Concentrating Hormone, salmon TFA
	Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是在硬骨鱼的垂体中发现的 19 个氨基酸组成的神经肽，它调节食物摄入，能量平衡，睡眠状态和心血管系统。Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是 SLC-1/GPR24和 MCHR2的配体。
T11966	MCHR1 antagonist 2	HER; Melanin-concentrating Hormone Receptor (MCHR)	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	MCHR1 antagonist 2 是有效的黑色素聚集激素受体 1 拮抗剂，IC50为 65 nM。它也抑制hERG，在IMR-32 细胞中的IC50为 4.0 nM。
TP1102	MCH (salmon) TFA (87218-84-6 free base) Melanin Concentrating Hormone, salmon TFA,MCH (salmon) TFA
	Melanin Concentrating Hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus. Melanin Concentrating Hormone is implicated in the control of general arousal and goal-orientated behaviours in mammals, and appears to be a key
T8004	SNAP 94847 hydrochloride	GPR; Melanin-concentrating Hormone Receptor (MCHR)	Endocrinology/Hormones; GPCR/G Protein
	SNAP 94847 hydrochloride 是一种选择性黑色素浓缩激素受体1 拮抗剂，Ki 为 2.2 nM，具有抗抑郁样活性。它是 MCH 诱发的肌醇磷酸形成的高亲和力拮抗剂，pA2为 7.81。
TP1996	MCH(human, mouse, rat) MCH (human, mouse, rat),黑色素聚集激酶素(MCH)( 大鼠)	GPR; Melanin-concentrating Hormone Receptor (MCHR)	Endocrinology/Hormones; GPCR/G Protein
	MCH(human, mouse, rat) 是MCH-R 肽激动剂，对 CHO 细胞系中 MCH-2R 高度敏感，激活 MCH-1R 和 MCH-2R 的IC50 值分别为 0.3 和 1.5 nM，EC50值对分别为 3.9 和 0.1 nM。
T7769	Nonapeptide-1 Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,九胜肽-1,Melanostatine™ 5	Others	Others
	Nonapeptide-1 (Melanostatine™ 5) 可以抑制黑色素的合成，这使得它对治疗某些皮肤病很感兴趣。
T5406	SNAP 94847 SNAP-94847	GPR; Melanin-concentrating Hormone Receptor (MCHR)	Endocrinology/Hormones; GPCR/G Protein
	SNAP 94847 (SNAP-94847) 是一种选择性黑色素浓缩激素受体1 拮抗剂，Ki 为 2.2 nM。它具有抗焦虑和抗抑郁活性，可减少小鼠的食物摄入。
T31423	Diazoluminolmelanin DALM
	Diazoluminolmelanin is a synthetic luminescent biopolymer.
T5955	Tricyclazole 三环唑,Tricyclazol	Antibacterial	Microbiology/Virology
	Tricyclazole (Tricyclazol) 是一种源自五肽的黑色素生物合成抑制剂，是一种独特的杀菌剂，用于防治水稻稻瘟病菌。
T9208	1,3,6,8-Tetrahydroxynaphthalene T4HN,1,3,6,8-THN,naphthalene-1,3,6,8-tetrol	Others	Others
	1,3,6,8-Tetrahydroxynaphthalene (T4HN) 是一种独特的对称聚酮起源化合物，是 DHN 黑色素不可缺少的前体。
T21588	Olomoucine	ERK; CDK	Cell Cycle/Checkpoint; MAPK
	Olomoucine 是 Cdk2/cyclin A、Cdc2/CyclinB、CDK2/CyclinE、CDK5/p35 和 ERK1/p44 MAP 激酶的 ATP 竞争性抑制剂，IC50 分别为 7、7、7、3 和 25 µM。 Olomoucine 调节细胞周期并表现出抗黑色素肿瘤活性。
T60278	Tyrosinase-IN-2	Tyrosinase	Proteases/Proteasome
	Tyrosinase-IN-2 (compound 67) 是一种有效的酪氨酸酶抑制剂。酪氨酸酶是一种含铜金属酶，负责黑色素生物合成和酶促褐变中的限速催化步骤。Tyrosinase-IN-2 具有研究皮肤美白剂和食品防腐剂的潜力。
T66491	4-(1-Phenylethyl)resorcinol 4-(1-Phenylethyl)benzene-1,3-diol,Phenylethyl resorcinol	Others	Others
	4-(1-Phenylethyl)resorcinol (4-(1-Phenylethyl)benzene-1,3-diol) 是一种亮肤剂，属于化妆品添加。它的作用是抑制黑色素的产生，减少黑斑、色素沉着和肤色不均的出现，提亮肤色减少皮肤暗沉。4-(1-Phenylethyl)resorcinol 在化妆品行业一般认为是安全的，在多个国家和地区广泛使用。
TP1097	Melanotan I 美拉诺坦,美拉诺坦 I,[Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I	Others	Others
	Melanotan I 是一种非特异性黑素皮质激素受体 (MCR) 激动剂，是一种 α- 黑素细胞刺激激素 (α-MSH) 类似物，皮下注射可增加黑色素在皮肤中的含量。Melanotan I 可用于辅助美黑。Melanotan I 可用于预防阳光诱发皮肤癌，可用于研究黑色素瘤和男性勃起功能障碍。
T28902	T-226296 T 226296,T226296
	T-226296 is a antagonist of melanin concentrating hormone receptor 1 (MCHR1).
T16852	SB-568849	Others	Others
	SB-568849 is a melanin-concentrating hormone receptor 1 antagonist (pKi: 7.7).
T23719	AMG-076
	AMG-076 is an antagonist of melanin-concentrating hormone receptor 1. It also reduced hERG inhibition.
T26677	ATC0175 ATC 0175,ATC-0175
	ATC0175 is a melanin-concentrating hormone receptor 1 antagonist with oral activity.
T14372	AZD1979	Others	Others
	AZD1979 is an antagonist of Melanin-concentrating hormone receptor 1 (MCHr1) (IC50: 12 nM).
T26676	ATC0065 ATC 0065,ATC-0065
	ATC0065 is a melanin-concentrating hormone receptor 1 antagonist with oral activity.
T28823	SNAP-7941 SNAP7941
	SNAP-7941 is a selective antagonist of the melanin concentrating hormone receptor MCH1 with promising anxiolytic, antidepressant and anorectic effects in initial animal studies.
T16293	NGD-4715	Others	Others
	NGD-4715 is a selective and orally active antagonist of melanin-concentrating hormone receptor 1.
T26703	AZ13483342 AZ-13483342,AZ 13483342
	AZ13483342 is an antagonist of the melanin concentrating hormone receptor 1 (MCH1) with a potential diabetes therapeutic activity.
T68845	Americanin A
	Americanin A natural thrombin inhibitor, suppressing melanin synthesis, regulating the ATM/ATR signaling pathway and the Skp2-p27 axis in human colon cancer cells.
T11964	MCH-1 antagonist 1	P450	Metabolism
	MCH-1 antagonist 1 also inhibits CYP3A4 (IC50: 10μM).MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist (Ki: 2.6 nM).
T69170	ATC0065 HCl
	ATC0065 dihydrochloride is a novel nonpeptidic and potent melanin-concentrating hormone receptor 1 (MCHR1) selective antagonist.
T71265	BMS-830216
	BMS-830216 is a nonbasic melanin hormone receptor 1 antagonist and a prodrug of BMS-819881.
T11965	MCHR1 antagonist 3	Others	Others
	MCHR1 antagonist 3, a potent antagonist of the melanin-concentrating hormone receptor-1 (MCHR1), is employed for the regulation of energy metabolism.
T10173	MCHR1 antagonist 1	Others	Others
	MCHR1 antagonist 1 is a selective antagonist of melanin-concentrating hormone-1 (MCH1) receptor (Kb: 1 nM, Ki: 4 nM at human MCH1).
T15450	GW-803430 GW-3430	Others	Others
	GW-803430 is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH R1) (pIC50: 9.3). GW-803430 is orally active in an animal model of obesity.
T69607	Dersimelagon phosphate
	Dersimelagon phosphate is a selective melanocortin-1 receptor (MC1R) agonist that increases skin melanin without sun exposure and is being developed to increase light tolerance in EPP/XLP patients.
TP1997	[Ala17]-MCH
	Potent melanin-concentrating hormone (MCH) receptor agonist (EC50 values are 17 and 54 nM at MCH1 and MCH2 receptors respectively). Displays some selectivity towards MCH1 over MCH2 (Ki values are 0.16 and 34 nM respectively).
T61460	Tyrosinase-IN-3
	Tyrosinase-IN-3 (compound 54) is a powerful tyrosinase inhibitor, an enzyme involved in the key catalytic step of melanin biosynthesis and enzymatic browning. As a copper-containing metalloenzyme, tyrosinase plays a crucial role in these processes. The compound shows promise for studying skin whitening agents and food preservatives [1].
T80207	Tetrapeptide	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Tetrapeptide 作为α-MSH的类似物，能促进黑色素的合成；其通过降低活性氧化物质生成和提升DNA光产物修复效率，有效减轻DNA损伤。
T7749	ALB-127158
	ALB-127158(a) 是一种有效的选择性黑色素浓缩激素 1 (MCH1) 受体拮抗剂，可能是炎症性肠病 (IBD) 的潜在治疗方法
T73598	Tyrosinase
	Tyrosinase(Polyphenol oxidase) 是控制黑色素产生的限速酶，由 TYR 基因编码。Tyrosinase 主要存在于皮肤黑素细胞合成的黑素体中。
T76640	hMCH-1R antagonist 1
	hMCH-1R antagonist 1 (Compound 30)为高效且具有选择性的hMCHR1拮抗剂，KB值仅为3.6 nM。它与hMCHR1和hMCHR2的结合能力强，IC50值分别为65 nM与49 nM，主要用于代谢研究领域。
T75714	Decapeptide-12
	Decapeptide-12，一个小型寡肽，作为tyrosinase的抑制剂，通过与tyrosinase的C末端残基相互作用(Kd: 61.1 μM)发挥作用。作为mushroom tyrosinase的竞争性抑制剂(IC50: 40 µM)，Decapeptide-12有效上调SIRT的转录水平，并能减少黑色素细胞中的黑色素含量，适用于黑色素生成、衰老和炎症的研究。
T73676	MIF-1 TFA
	MIF-1 TFA（Melanostatin）是一种内源性脑肽，具有有效调节多巴胺受体变构的作用，并抑制黑色素生成。此外，它通过阻断阿片受体的激活，调控吗啡的镇痛效果及应激诱导的镇痛（SIA）。MIF-1 TFA 能直接穿过血脑屏障（BBB）进入中枢神经系统。
T75715	Nonapeptide-1 acetate salt
	Nonapeptide-1 (Melanostatine-5) acetate salt，一种多肽类激素，是 MC1R 选择性拮抗剂 (Ki: 40 nM)。 Nonapeptide-1 acetate salt 是一种竞争性的α-MSH 拮抗剂，可有效抑制黑素细胞中 α-MSH 诱导的细胞内 cAMP 和黑素体扩散 (IC50分别为 2.5 nM 和 11 nM)。 Nonapeptide-1 acetate salt 抑制黑色素合成，可用于研究皮肤色素沉着和肾上腺类固醇生成的调节、皮肤癌。

化合物

Melanin Concentrating Hormone, salmon acetate

Cat.No: TP1104L

Synonym: MCH (salmon),Melanin Concentrating Hormone, salmon acetate(87218-84-6 free base)

Target: Others, Melanin-concentrating Hormone Receptor (MCHR)

Melanin probe-1

Cat.No: T38855

Melanin Concentrating Hormone, salmon

Cat.No: TP1104

Synonym: MCH (salmon)

Melanin probe-2

Cat.No: T64640

Melanin Concentrating Hormone, salmon TFA

Cat.No: T75970

MCHR1 antagonist 2

Cat.No: T11966

Target: HER, Melanin-concentrating Hormone Receptor (MCHR)

MCH (salmon) TFA (87218-84-6 free base)

Cat.No: TP1102

Synonym: Melanin Concentrating Hormone, salmon TFA,MCH (salmon) TFA

SNAP 94847 hydrochloride

Cat.No: T8004

Target: GPR, Melanin-concentrating Hormone Receptor (MCHR)

MCH(human, mouse, rat)

Cat.No: TP1996

Synonym: MCH (human, mouse, rat),黑色素聚集激酶素(MCH)( 大鼠)

Target: GPR, Melanin-concentrating Hormone Receptor (MCHR)

Cat.No: T7769

Synonym: Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-,九胜肽-1,Melanostatine™ 5

Target: Others

Cat.No: T5406

Synonym: SNAP-94847

Target: GPR, Melanin-concentrating Hormone Receptor (MCHR)

Diazoluminolmelanin

Cat.No: T31423

Synonym: DALM

Cat.No: T5955

Synonym: 三环唑,Tricyclazol

Target: Antibacterial

1,3,6,8-Tetrahydroxynaphthalene

Cat.No: T9208

Synonym: T4HN,1,3,6,8-THN,naphthalene-1,3,6,8-tetrol

Target: Others

Cat.No: T21588

Target: ERK, CDK

Tyrosinase-IN-2

Cat.No: T60278

Target: Tyrosinase

4-(1-Phenylethyl)resorcinol

Cat.No: T66491

Synonym: 4-(1-Phenylethyl)benzene-1,3-diol,Phenylethyl resorcinol

Target: Others

Cat.No: TP1097

Synonym: 美拉诺坦,美拉诺坦 I,[Nle4,D-Phe7]-α-MSH,Afamelanotide,MT-I

Target: Others

Cat.No: T28902

Synonym: T 226296,T226296

Cat.No: T16852

Target: Others

Cat.No: T23719

Cat.No: T26677

Synonym: ATC 0175,ATC-0175

Cat.No: T14372

Target: Others

Cat.No: T26676

Synonym: ATC 0065,ATC-0065

Cat.No: T28823

Synonym: SNAP7941

Cat.No: T16293

Target: Others

Cat.No: T26703

Synonym: AZ-13483342,AZ 13483342

Cat.No: T68845

MCH-1 antagonist 1

Cat.No: T11964

Target: P450

Cat.No: T69170

Cat.No: T71265

MCHR1 antagonist 3

Cat.No: T11965

Target: Others

MCHR1 antagonist 1

Cat.No: T10173

Target: Others

Cat.No: T15450

Synonym: GW-3430

Target: Others

Dersimelagon phosphate

Cat.No: T69607

Cat.No: TP1997

Tyrosinase-IN-3

Cat.No: T61460

Cat.No: T80207

Target: DNA/RNA Synthesis

Cat.No: T7749

Cat.No: T73598

hMCH-1R antagonist 1

Cat.No: T76640

Cat.No: T75714

Cat.No: T73676

Nonapeptide-1 acetate salt

Cat.No: T75715

Cat. No.	Product Name	Target	Signaling Pathways
T3816	Velutin	NF-κB; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; NF-κB
	Velutin 是一种苷元，提取自槲寄生中，能够抑制黑色素生物合成。它利用 NF-κB 途径减少破骨细胞分化和下调 HIF-1α。
TN1545	D-Tyrosine	Tyrosinase	Proteases/Proteasome
	D-Tyrosine，是酪氨酸的D异构体，通过抑制酪氨酸酶活性，作为黑色素合成的负向调节剂。此外，D-Tyrosine还能抑制生物膜的形成，并诱导生物膜的自我分散，同时不影响细菌的生长。
T9135	Epirosmanol	Others	Others
	Epirosmanol 是含有内酯部分的二萜类化合物。 Epirosmanol 是一种极弱碱性（基本中性）的化合物（基于其 pKa）。
T7052	Gnetol	Tyrosinase; COX; HDAC; AChR	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Neuroscience; Proteases/Proteasome
	Gnetol 是从买麻藤的根中分离出来的一种酚类。它是酪氨酸酶抑制剂，对鼠酪氨酸酶的 IC50为 4.5 μM，可抑制黑色素的生物合成。它有效抑制 COX-1和 HDAC，具有抗氧化、抗增殖、抗癌和保肝活性，还具有浓度依赖性的 α-淀粉酶、α-葡萄糖苷酶和脂肪形成活性。
T5826	Eupalinolide A	HSP	Cytoskeletal Signaling; Metabolism
	Eupalinolide A 是分离于林泽兰中的一种天然产物，通过抑制 HSF1 与 HSP90 的相互作用，激活 HSF1，诱导 HSP70 的表达。它对 A-549、BGC-823、SMMC-7721 和 HL-60 肿瘤细胞系具有强大的细胞毒性。
TN6901	Methyl myristate 肉豆蔻酸甲酯,methyl tetradecanoate	Others	Others
	Methyl myristate (methyl tetradecanoate) 是一种肉豆蔻酸经酯化反应得到的饱和脂肪酸甲酯。对 B16F10 黑色素瘤具有显著的诱导作用。
T8244	Raspberry ketone glucoside 覆盆子酮葡糖苷,树莓苷，覆盆子酮葡萄糖甙	Others	Others
	Raspberry ketone glucoside 是一种山莓果实中的天然产物。它能够抑制黑色素的合成。
T1310	2-Thiouracil Thiouracil,硫代由雪,Deracil,2-硫脲嘧啶	Thyroid hormone receptor(THR); NO Synthase	Endocrinology/Hormones; Immunology/Inflammation
	2-Thiouracil (Deracil) 是神经型一氧化氮合酶 (nNOS) 的选择性抑制剂(Ki:20 μM)，是一种抗甲状腺化合物，可用作高度特异性的黑色素瘤探测物。
T2P2810	Methyl Linoleate Linoleic acid methyl ester,亚油酸甲酯,Telfairic Acid methyl ester	Antioxidant	oxidation-reduction
	Methyl Linoleate (Telfairic Acid methyl ester) 是一种 Sageretia thea 果实的主要活性成分，能够下调小眼畸形相关转录因子和酪氨酸酶相关蛋白，是一种主要的抗黑色素生成化合物。
T2819	Methyl p-coumarate 对羟基肉桂酸乙酯,4-羟基肉桂酸甲酯,Methyl 4-hydroxycinnamate	Others; Antifungal	Microbiology/Virology; Others
	Methyl 4-hydroxycinnamate 是一种从 Trixis michuacanavarlongifolia 的花中分离出来的对香豆酸的酯化衍生物，有抗菌和抗黑色素形成的作用。
T5985	Glycolic acid	Tyrosinase; Endogenous Metabolite	Metabolism; Proteases/Proteasome
	Glycolic acid 是一种酪氨酸酶抑制剂，可以抑制黑色素的形成，从而减淡皮肤的颜色。
TQ0118	Britannilactone Desacetylinulicin,旋覆花内酯	Others	Others
	Britannilactone, extracted from the dried flower of Inula britannica L, significantly reduces melanin production in a dose-dependent manner (IC50: 15.5 uM).
TN3231	Pratol 7-Hydroxy-4'-methoxyflavone,三叶草,车轴草醇	Others	Others
	Pratol (7-Hydroxy-4'-methoxyflavone) 显着增加细胞中的黑色素含量和酪氨酸酶活性，而没有细胞毒性。
T0689	D-Phenylalanine	Endogenous Metabolite; Monocarboxylate transporter	Membrane transporter/Ion channel; Metabolism
	D-Phenylalanine 是一种苯丙氨酸的合成右旋异构体，可抑制Pseudoalteromonas sp.SC2014 的生物膜发育。
T0759	Monobenzone 4-苄氧基苯酚,Benoquin	Tyrosinase	Proteases/Proteasome
	Monobenzone (Benoquin) 是皮肤脱色剂。它可引起色素脱失和活跃的人白癜风，对白癜风具有潜在的研究价值。
T3676	Sesamol 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Sesamol (1,3-Benzodioxol-5-ol) 是芝麻油的主要成分，具有抗氧化和抗肿瘤活性。它是一种自由基清除剂，在 DPPH 实验中，IC50为 5.95±0.56 μg/mL。
T19924	Rhododendrol Betuligenol,Frambinol,杜鹃醇	Others	Others
	Rhododendrol (Frambinol) 是一种黑色素合成物，防止雄性小鼠高脂饮食引起的体重升高和增加雄性小鼠白色脂肪细胞的脂肪分解。Rhododendrol 可用作美白/美白化妆品抑制剂。
T5889	Kojic acid	Tyrosinase; Parasite	Microbiology/Virology; Proteases/Proteasome
	Kojic acid 是 Aspergillus oryzae 产生的一种真菌代谢物，用作抗氧化剂和防辐射剂，可抑制酪氨酸酶。
TN2296	Vinaginsenoside R4 越南参皂苷R4	Others	Others
	Vinaginsenoside R4 是分离自水培人参的叶子中。它能够抑制黑色素的生物合成，并增强斑马鱼的色素沉着，对 melan-a 细胞没有任何细胞毒性作用。
T10164	5,6-Dihydroxyindole Dopamine lutine	Endogenous Metabolite	Metabolism
	5,6-Dihydroxyindole (Dopamine lutine) 是黑色素的前体，显示出广谱的抗菌，抗真菌，抗病毒，抗寄生虫活性。5,6-Dihydroxyindole 也显示出细胞毒性作用。
T5755	Aloesin	Tyrosinase	Proteases/Proteasome
	Aloesin 是芦荟的活性成分之一，能够通过 MAPK 信号通路发挥抗癌作用，并具有抗炎、紫外线保护和抗菌作用。
T0473	Arbutin Uva,p-Arbutin,p-Arbutin,熊果苷,β-Arbutin	Tyrosinase	Proteases/Proteasome
	Arbutin (p-Arbutin) 是一种从熊果植物 Arctostaphylos uvaursi 中分离出的天然多酚，具有抗氧化，抗炎和抗肿瘤特性。它是一种脱色剂，也是一种黑色素细胞中酪氨酸酶的竞争性抑制剂，对单酚酶的 Kiapp 值为 1.42 mM；对二酚酶Kiapp 的值为 0.9 mM。
TN6972	Methyl pentadecanoate	Others	Others
	Methyl pentadecanoate 是一种天然产物。它是由肉豆蔻酸酯化得到的饱和脂肪酸甲酯。肉豆蔻酸甲酯(Methyl myristate) 在 B16F10 黑色素瘤中显示出高黑色素诱导。
T4S0998	Trifolirhizin 红车轴草根甙/三叶豆紫檀苷,三叶豆紫檀苷	TNF; Tyrosinase	Apoptosis; Proteases/Proteasome
	Trifolirhizin 是一种从苦参根中分离出的 pterocarpan 黄酮类化合物。它具有酪氨酸酶高抑制活性，IC50=506 μM。它具有抗炎和抗癌的潜能。
T3S0645	N-trans-Feruloyltyramine Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺	Others; COX	Immunology/Inflammation; Neuroscience; Others
	N-trans-Feruloyltyramine (Feruloyltyramine) 是从大麻中分离得到的一种生物碱，是COX1和COX2的抑制剂，具有抗氧化和抗炎活性。
T5S1177	Aloin B Isobarbaloin,芦荟苷B,芦荟素B	Others	Others
	Aloin B (Isobarbaloin) 是一种芦荟素的异构体。其中芦荟素是芦荟中的具生理活性蒽醌化合物。
TCS2070	Homogentisic acid 高龙胆酸,2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid	Antioxidant; Endogenous Metabolite	Metabolism; oxidation-reduction
	Homogentisic acid (2,5-dihydroxyphenylacetic acid) 是一种尿液和血清代谢物中的特定代谢物，可用于尿黑酸尿症的诊断。
T3606	γ-Oryzanol 谷维素,Gamma-Oryzanol,Oliver,γ-谷维素,Gammariza	DNA Methyltransferase	Chromatin/Epigenetic
	γ-Oryzanol (Gamma-Oryzanol) 是一种从米糠油中分离出来的营养提取物，是含有甾醇和阿魏酸的混合物，有助于破坏皮肤中的自由基。它有效抑制小鼠纹状体中的 DNA 甲基转移酶(DNMTs)。它抑制DNMT1和DNMT3a，IC50分别为 3.2 和 22.3 μM。
TN2601	12-O-Methylcarnosic acid	Reductase	Endocrinology/Hormones; Metabolism
	12-O-Methylcarnosic acid 是分离自小叶丹参的丙酮提取物的一种二萜肉桂酸，可抑制 5α-还原酶 (5α-reductase) 活性，IC50为 61.7 μM。它抑制 LNCaP 细胞的增殖。它具有抗微生物活性、抗氧化和抗癌活性。
TN4085	Fupenzic acid	Others	Others
	Fupenzic acid shows a significant decrease in intracellular melanin content in B16-F10 cells, and in culture media melanin.
TN1320	6-O-Caffeoylarbutin	Others	Others
	6'-O-caffeoylarbutin may serve as a skin-whitening ingredient with the merits of potent melanin inhibition,less toxicity and reversible melanin synthesis after stopping use.
TN4642	Neorauflavane	Tyrosinase	Proteases/Proteasome
	Neorauflavane shows tyrosinase inhibition, it can inhibit tyrosinase monophenolase activity with an IC50 of 30 nM, it also can efficiently reduce melanin content in B16 melanoma cells with 12.95 uM of IC50.
TN2792	2-Oxopomolic acid
	2-Oxopomolic acid shows cytotoxic activity, it shows a significant decrease in intracellular melanin content in B16-F10 cells, and in culture media melanin. 2-Oxopomolic acid shows radical-scavenging activities similar to that of the reference antioxidant
TN4329	Isosaxalin	Others	Others
	Isosaxalin, heraclenin and heraclenol 3'-Me ether have melanin biosynthesis inhibitory activities.
T13762	Luteolin 7-sulfate	Others	Others
	Luteolin 7-sulfate, derived from the marine plant Phyllospadix iwatensis Makino, suppresses TYR gene expression by intervening in a signaling pathway involving the cAMP-responsive element binding protein (CREB) and microphthalmia-associated transcription factor (MITF). This inhibition ultimately leads to a decrease in melanin synthesis.
TN3644	Chlorophorin	Tyrosinase; Antifection	Microbiology/Virology; Proteases/Proteasome
	Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values of 2.5 ± 0.408 uM; it inhibits α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells.
TN1840	Kurarinol	Tyrosinase; HBV; STAT	JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
	Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, is a candidate as skin-whitening agents.
TN5477	GB-2a
	GB 2a shows antioxidant and anti-inflammatory effects, it can prevent the carrageenan-induced paw oedema. GB 2a biflavonoid can promote inhibition on tyrosinase activity and reduced melanin biosynthesis in B16F10 cells, which suggests great potential for
TN3003	4-(3,4-Dimethoxyphenyl)-3-buten-1-ol	ERK; p38 MAPK	MAPK
	(E)-4-(3,4-dimethoxyphenyl)but-3-en-1-ol may promote melanin synthesis via USF1 dependent fashion and could be used as a clinical therapeutic agent against hypopigmentation-associated diseases.
TMA0003	Trans-caffeic acid	cAMP; Tyrosinase	GPCR/G Protein; Proteases/Proteasome
	Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyrosinase activity, DOPA oxidase activity and melanin synthesis.
T20612	4,5,6,7-Tetrachlorophthalide KF 32,KF32,Rabcide,KF-32,Fthalide
	4,5,6,7-Tetrachlorophthalide is a fungicide used for the control of rice blast. It has a role as a melanin synthesis inhibitor and an antifungal agrochemical.
TN2280	Trametenolic acid	Tyrosinase	Proteases/Proteasome
	Trametenolic acid is a cytotoxic agent.It exhibits a mode of mixed inhibition with a K I of 0.9μM, K IS of 0.5μM, and an IC50 of 7.25μM.Trametenolic acid and Betulin as a new candidate of potent tyrosinase inhibitors, can decrease tyrosinase activity and melanin content.
T75506	6-Acetylnimbandiol
	6-Acetylnimbandiol (6-O-Acetylnimbandiol) 是一种无细胞毒性的 tyrosinase 抑制剂 (IC50=69.85 μM)，能有效抑制黑色素的生成和MITF 的表达。6-Acetylnimbandiol 可用于黑色素瘤的研究。
TN4699	Ohchinin	Others	Others
	Ohchinin exhibits potent inhibitory activities with 26 - 66% reduction of melanin content at 100 μm concentration with almost no or low toxicity to the B16 melanoma cells (70 - 99% cell viability at 100 μm).
TN3009	4',5,7-Trihydroxy-6-prenylflavone	Others	Others
	6-Prenylapigenin(4',5,7-Trihydroxy-6-prenylflavone) shows potent inhibitory activity on melanin formation, it may be potential sources for skin whitening agents. It also shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarci
TN1958	Mulberroside F 桑皮苷F,桑皮苷 F	Tyrosinase	Proteases/Proteasome
	Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells, it also exhibits superoxide scavenging activity that is involved in the protection against auto-oxidation, suggests that mulberroside F may be us
TN3882	Dodoviscin A	cAMP; Tyrosinase; transporter	GPCR/G Protein; Metabolism; Proteases/Proteasome
	Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isobutyl-1-methylxanthine and PD98059.Dodoviscin A can promote adipocyte differentiation as charact
T83344	3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside
	3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside 是Polaskia chichipeBackbg 中分离的一种皂苷，具有抑制B16黑色素瘤细胞中黑色素生物合成的活性，100 μM 浓度可达到84.2%的抑制效果。
TN3753	Dalbergioidin	Tyrosinase; ROS; Akt; PI3K; TGF-beta/Smad	Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator organism. Dalbergioidin protects MC3T3-E1 osteoblastic cells against H2O2-induced cell damage through activation of the PI3K/AKT/SMAD1 pathway, suggests that it may be useful in bone metabolism diseases, particularly osteoporosis. Dalbergioidin also ameliorates doxorubicin-induced ...
T75554	6-O-Isobutyrylbritannilactone
	6-O-Isobutyrylbritannilactone 是一种天然的黑素生成抑制剂。6-O-Isobutyrylbritannilactone 是一种倍半萜，可从英菊花中分离得到。6-O-Isobutyrylbritannilactone 抑制 IBMX 诱导 B16F10 细胞产生黑色素。6-O-Isobutyrylbritannilactone 也调控 ERK、PI3K/AKT 和 CREB，在斑马鱼胚胎模型中显示出抗黑色素原活性。
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天然产物

Cat.No: T3816

Target: NF-κB, HIF/HIF Prolyl-Hydroxylase

Cat.No: TN1545

Target: Tyrosinase

Cat.No: T9135

Target: Others

Cat.No: T7052

Target: Tyrosinase, COX, HDAC, AChR

Cat.No: T5826

Target: HSP

Methyl myristate

Cat.No: TN6901

Synonym: 肉豆蔻酸甲酯,methyl tetradecanoate

Target: Others

Raspberry ketone glucoside

Cat.No: T8244

Synonym: 覆盆子酮葡糖苷,树莓苷，覆盆子酮葡萄糖甙

Target: Others

Cat.No: T1310

Synonym: Thiouracil,硫代由雪,Deracil,2-硫脲嘧啶

Target: Thyroid hormone receptor(THR), NO Synthase

Methyl Linoleate

Cat.No: T2P2810

Synonym: Linoleic acid methyl ester,亚油酸甲酯,Telfairic Acid methyl ester

Target: Antioxidant

Methyl p-coumarate

Cat.No: T2819

Synonym: 对羟基肉桂酸乙酯,4-羟基肉桂酸甲酯,Methyl 4-hydroxycinnamate

Target: Others, Antifungal

Cat.No: T5985

Target: Tyrosinase, Endogenous Metabolite

Britannilactone

Cat.No: TQ0118

Synonym: Desacetylinulicin,旋覆花内酯

Target: Others

Cat.No: TN3231

Synonym: 7-Hydroxy-4'-methoxyflavone,三叶草,车轴草醇

Target: Others

D-Phenylalanine

Cat.No: T0689

Target: Endogenous Metabolite, Monocarboxylate transporter

Cat.No: T0759

Synonym: 4-苄氧基苯酚,Benoquin

Target: Tyrosinase

Cat.No: T3676

Synonym: 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚

Target: Apoptosis, AMPK

Cat.No: T19924

Synonym: Betuligenol,Frambinol,杜鹃醇

Target: Others

Cat.No: T5889

Target: Tyrosinase, Parasite

Vinaginsenoside R4

Cat.No: TN2296

Synonym: 越南参皂苷R4

Target: Others

5,6-Dihydroxyindole

Cat.No: T10164

Synonym: Dopamine lutine

Target: Endogenous Metabolite

Cat.No: T5755

Target: Tyrosinase

Cat.No: T0473

Synonym: Uva,p-Arbutin,p-Arbutin,熊果苷,β-Arbutin

Target: Tyrosinase

Methyl pentadecanoate

Cat.No: TN6972

Target: Others

Cat.No: T4S0998

Synonym: 红车轴草根甙/三叶豆紫檀苷,三叶豆紫檀苷

Target: TNF, Tyrosinase

N-trans-Feruloyltyramine

Cat.No: T3S0645

Synonym: Feruloyltyramine,N-Feruloyltyramine,Moupinamide,N-反式阿魏酰酪胺

Target: Others, COX

Cat.No: T5S1177

Synonym: Isobarbaloin,芦荟苷B,芦荟素B

Target: Others

Homogentisic acid

Cat.No: TCS2070

Synonym: 高龙胆酸,2,5-dihydroxyphenylacetic acid,Homogentisinic Acid,Melanic acid

Target: Antioxidant, Endogenous Metabolite

Cat.No: T3606

Synonym: 谷维素,Gamma-Oryzanol,Oliver,γ-谷维素,Gammariza

Target: DNA Methyltransferase

12-O-Methylcarnosic acid

Cat.No: TN2601

Target: Reductase

Cat.No: TN4085

Target: Others

6-O-Caffeoylarbutin

Cat.No: TN1320

Target: Others

Cat.No: TN4642

Target: Tyrosinase

2-Oxopomolic acid

Cat.No: TN2792

Cat.No: TN4329

Target: Others

Luteolin 7-sulfate

Cat.No: T13762

Target: Others

Cat.No: TN3644

Target: Tyrosinase, Antifection

Cat.No: TN1840

Target: Tyrosinase, HBV, STAT

Cat.No: TN5477

4-(3,4-Dimethoxyphenyl)-3-buten-1-ol

Cat.No: TN3003

Target: ERK, p38 MAPK

Trans-caffeic acid

Cat.No: TMA0003

Target: cAMP, Tyrosinase

4,5,6,7-Tetrachlorophthalide

Cat.No: T20612

Synonym: KF 32,KF32,Rabcide,KF-32,Fthalide

Trametenolic acid

Cat.No: TN2280

Target: Tyrosinase

6-Acetylnimbandiol

Cat.No: T75506

Cat.No: TN4699

Target: Others

4',5,7-Trihydroxy-6-prenylflavone

Cat.No: TN3009

Target: Others

Cat.No: TN1958

Synonym: 桑皮苷F,桑皮苷 F

Target: Tyrosinase

Cat.No: TN3882

Target: cAMP, Tyrosinase, transporter

3-O-β-D-Glucopyranosyl(1→2)-[a-Lrhamnopyranosyl(1→3)]-β-D-glucopyranosyl 28-O-β-D-glucuronopyranoside

Cat.No: T83344

Cat.No: TN3753

Target: Tyrosinase, ROS, Akt, PI3K, TGF-beta/Smad

6-O-Isobutyrylbritannilactone

Cat.No: T75554

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