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Search Results for " insulin resistance "

39

抑制剂 & 化合物

17

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21955	GQ-16	PPAR	DNA Damage/DNA Repair; Metabolism
	GQ-16 是 PPARγ 的部分激动剂，Ki 为 160 nM。 GQ-16 可减少脂肪生成作用并促进胰岛素敏化而不会增加体重。
T4628	Seladelpar MBX 8025	PPAR	DNA Damage/DNA Repair; Metabolism
	Seladelpar (MBX 8025) 是一种有效的，具有口服活性的，特异性PPAR-δ激动剂，EC50为 2 nM。
T7656	Apelin-13
	Apelin-13 是存在于中枢和外周神经系统由13个氨基酸组成的多肽序列，是 G 蛋白偶联受体angiotensin II protein J (APJ) 的内源性配体，对 APJ 的 EC50 值为 0.37 nM。Apelin-13 具有扩张血管和降压活性，可用于研究 2 型糖尿病综合征。
T7714	Temocapil	Tyrosinase	Proteases/Proteasome
	Temocapil 是一种酪氨酸激酶抑制剂。
T10353	APX-115 free base Ewha-18278 free base	NADPH-oxidase; NADPH	Immunology/Inflammation; Metabolism
	APX-115 free base (Ewha-18278 free base) 是口服具有活性的、非选择性的 Nox 抑制剂，对 Nox1，Nox2和 Nox4的 Ki 分别为 1.08 μM，0.57 μM 和 0.63 μM。它能够有效预防糖尿病小鼠的肾损伤。
T6698	Temocapril hydrochloride CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利	RAAS	Endocrinology/Hormones
	Temocapril hydrochloride (CS-622 HCl) 是血管紧张素转化酶 (ACE) 抑制剂。Temocapril HCl 能够用于充血性心力衰竭、急性心肌梗死、高血压、胰岛素抵抗和肾脏疾病的研究。
T26656	ARH-049020 X334,X-334,X 334,ARH 049020
	ARH-049020, a peroxisome proliferator-activated receptor (PPAR) agonist, is used potentially for the treatment of insulin resistance and type 2 diabetes.
T76664	Adropin (34-76) (human, mouse, rat)
	Adropin (34-76) (human, mouse, rat) 是一种多肽，可减轻肝纤维化和胰岛素抵抗，而不依赖于肥胖或食物摄入。
T38715	MSDC-0602K MSDC-0602K,Azemiglitazone potassium	PPAR	DNA Damage/DNA Repair; Metabolism
	MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both ...
T30579	BRD4097	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BRD4097是HDAC1/2/3/8检测中的阴性对照品,是一种选择性组蛋白去乙酰化酶（HDAC3）抑制剂，可用于保护b 细胞和改善胰岛素抵抗，有助于促进认知功能和增强学习和记忆的形成。
T62656	GPR81 agonist 1	GPR	Endocrinology/Hormones; GPCR/G Protein
	GPR81 agonist 1 是一种具有高效性和选择性的 GPR81 激动剂，对人和小鼠 GPR81 具有很高的亲和力。GPR81 agonist 1 抑制分化的 3T3-L1 脂肪细胞的脂解，改善胰岛素抵抗和糖尿病小鼠模型的胰岛素敏感性和血糖控制，可用于研究糖尿病和肥胖。
T78169	Enpp-1-IN-16	PDE	Metabolism
	Enpp-1-IN-16 是一种靶向 ENPP1 的抑制剂，具有潜在的抗癌症活性。Enpp-1-IN-16 可用于研究胰岛素抵抗与II型糖尿病和软骨钙化病和骨关节炎类由 ENPP1介导的各类疾病。
T72617	Nampt activator-2	P450; NAMPT	Metabolism
	Nampt activator-2 是一种 NAMPT 激活剂（EC50 ： 0.023 μM）。 Nampt activator-2 对 CYP2C9、2D6、2C19 具有亲和力，亲和力数值分别为 0.060 μM、 0.41 μM 和 0.59 μM 。Nampt activator-2 可用来研究动脉粥样硬化，肥胖，II型糖尿病，胰岛素抵抗和I型糖尿病。
T62238	AMPK activator 4	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	AMPK activator 4 是一种有效且具有选择性的AMPK激活剂，不抑制线粒体复合物 I。AMPK activator 4 选择性地激活肌肉组织中的 AMPK且剂量依赖性地改善正常小鼠的糖耐量，显著降低 db/db 糖尿病小鼠的空腹血糖水平和改善胰岛素抵抗。AMPK activator 4 具有降血糖作用。
T27706	K-111 BM170744,BM 170744,BM-170744,K111
	K-111 is a PPAR alpha agonist. K-111 improves insulin resistance, reducing bodyweight, and ameliorating atherogenic dyslipidemia.
T25780	MDK-4823 LMPTP-IN-23,LMPTP-IN 23,MDK4823,LMPTP-IN23,MDK 4823
	MDK-4823, also known as LMPTP inhibitor1, is a potent low-molecular-weight tyrosine phosphatase (LMPTP) inhibitor. LMPTP is highly expressed in insulin-target tissues. LMPTP promotes diabetes and insulin resistance in obesity.
T28511	Reglitazar JTT-501,JTT501,PNU-182716,PNU182716,PNU-716
	Reglitazar is a PPARɑ agonist and PPARγ agonist. Reglitazar rapidly stimulates glucose disposal rates by enhancing insulin signal transduction in skeletal muscle. Reglitazar improves insulin resistance in genetic and non-genetic insulin-resistant models.
T68132	quercetin-3'-o-phosphate
	Quercetin-3'-O-phosphate belongs to the class of organic compounds known as flavonols,has been used in trials studying the treatment of Insulin Resistance and Impaired Glucose Tolerance.
T31732	Evogliptin HCl Evogliptin hydrochloride,DA 1229,DA1229,Evogliptin,DA-1229
	Evogliptin(DA-1229) is a potent and selective DPP4 inhibitor (dipeptidyl peptidase 4 inhibitor) that can improve insulin resistance and delays the onset of diabetes. Evogliptin delays the onset of diabetes in young db/db mice and improves insulin sensitiv
T70141	MDK80908
	MDK80908, also known as PPARalpha/gamma agonist N15, is a dual PPARα/γ agonist, ameliorating insulin resistance and gluconeogenesis in vivo and vitro. MDK80908 has CAS#1821380-90-8.
T60696	CXCR2 antagonist 8
	CXCR2 antagonist 8 是可用于研究胰岛素抵抗的，CXCR2受体的选择性拮抗剂。
TP1183	Amylin, amide, human DAP amide, human
	Amylin, a 37-amino acid polypeptide that is structurally related to calcitonin, is secreted from the B cells of the pancreas. Amylin has anoretic effects in rats. Amylin may be responsible for the etiology of insulin resistance of type II diabetes mellitu
T38764	Amylin (8-37), human
	Amylin (8-37), human, derived from human Amylin, possesses direct vasodilator effects in isolated mesenteric resistance arteries of rats. Human Amylin is a small pancreatic β-cell hormone that forms aggregates in the absence of insulin and is a key pathological feature of type II diabetes mellitus.
T15043	D5D-IN-326	Others	Others
	D5D-IN-326 is an orally active delta-5 desaturase (D5D) inhibitor (IC50s: 72 and 22 nM for rat and human D5D in enzymic and cell-based assays). It has no effect on D6D or D9D activity. D5D-IN-326 reduces insulin resistance and decreases body weight in die
T74716	Curcumin 5-8
	Curcumin 5-8 (CUR5-8)，一种CUR类天然活性姜黄素类似物，具有抑制脂滴形成、促进细胞自噬 (autophagy)、抑制细胞凋亡 (Apoptosis) 以及改善胰岛素抵抗和胰岛素敏感性的功能。
T71251	DS-1558
	DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyperglycemia and increased insulin secretion during the oral glucose tolerance test in Zucker fatty rats, the model of insulin resistance and glucose intolerance. DS-1558 not only increased the glucose-stimulated insulin secretion by GLP-1 but also potentiated the maximum insulinog...
T35588	Ganglioside GM3 Mixture (sodium salt)
	Ganglioside GM3 is a monosialoganglioside that demonstrates antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation. It suppresses angiogenesis and reduces proliferation and migration of human umbilical vein endothelial cells (HUVECs) when used at a concentration of 20 μM via inhibition of VEGFR2 and Akt phosphorylation. Ganglioside GM3 induces dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functi...
T80915	Tyr0-Neurokinin A
	Tyr0-Neurokinin A，一种神经肽，隶属于速激肽家族，作为Tacr2的激动剂，适用于胰岛素抵抗、肥胖和糖尿病研究领域。
T39490	Aclimostat ZGN-1061,Aclimostat
	Aclimostat (ZGN-1061) is a highly potent inhibitor of the MetAP2 enzyme that demonstrates promising efficacy and safety profiles in preclinical trials. In a mouse model of obesity and insulin resistance, ZGN-1061 exhibits comparable weight loss efficacy to beloranib, while also improving metabolic parameters. Additionally, ZGN-1061 induces consistent changes in gene transcription in HepG2 cells, further supporting its positive pharmacological effects.
T76310	Acetyl Gastric Inhibitory Peptide (human)
	AcetylGastric Inhibitory Peptide(human)，一种脂肪酸衍生的葡萄糖依赖性胰岛素多肽类似物，具备改善抗高血糖和胰岛素敏感性的特性。适用于糖尿病、胰岛素抵抗及肥胖研究。
T35809	C20 Sphingomyelin (d18:1/20:0)
	C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in m...
TP2019	[D-Ala2]-GIP (human)
	Highly potent GIP receptor agonist (EC50 = 630 ± 119 pM). Displays equivalent cAMP stimulating properties and improved resistance to enzymatic degradation compared to native GIP in cells expressing wild type GIP receptor. Improves glucose tolerance, insul
T78543	Acetyl Gastric Inhibitory Peptide (human) TFA Human N-acetyl GIP TFA
	AcetylGastric Inhibitory Peptide(human) TFA 是一种葡萄糖依赖性胰岛素释放多肽的改性脂肪酸衍生物，具有增强的抗高血糖和促胰岛素作用。它主要用于糖尿病、胰岛素抵抗和肥胖的科研领域。
T68808	11-Dehydrocorticosterone
	11-Dehydrocorticosterone is an endogenous mineralocorticoid. It increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner. 11-Dehydrocorticosterone decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of 11β-hydroxysteroid dehydrogenase inhibition induced by carbenoxolone. Chronic administration 11-dehydro...
T35799	MBX-8025 (sodium salt)
	MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increases in fasting blood glucose and serum insulin levels, and decreases insulin resistance in Alms1 mutant (foz/foz) mice fed an atherogenic diet as a model of diet-induced obesity, type 2 diabetes, and non-alcoholic steatohepatitis (NASH).2 It also decreases serum alanine transamin...
T72889	FXR agonist 4
	FXR agonist4，一种法尼酯X受体(FXR)激动剂，具有1.05 μM的EC50值。该化合物在DIO小鼠模型中有效地改善了高脂血症、肝脏脂肪变性、胰岛素抵抗以及肝脏炎症，因此可用于非酒精性脂肪性肝病(NAFLD)的研究。
T36582	Glucocerebrosides (Gaucher's spleen)
	Glucocerebrosides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase. They are present in neuronal and non-neuronal mammalian tissues and are found at low quantities in a large number of plant species. Glucocerebrosides are precursors in the synthesis of lactosylceramides and gangliosides. Increased levels of glucocerebrosides are associated with obesity-induced insulin resistance in mice and with neuronal deficits observed in neuronopathic Gaucher disease. This pr...
T71981	Gliclazide-d4
	Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin...
T35634	Platensimycin
	Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM). It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively). By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic ...

化合物

Cat.No: T21955

Target: PPAR

Cat.No: T4628

Synonym: MBX 8025

Target: PPAR

Cat.No: T7656

Cat.No: T7714

Target: Tyrosinase

APX-115 free base

Cat.No: T10353

Synonym: Ewha-18278 free base

Target: NADPH-oxidase, NADPH

Temocapril hydrochloride

Cat.No: T6698

Synonym: CS-622 HCl,Acecol,Temocapril HCl,CS-622,盐酸替莫普利

Target: RAAS

Cat.No: T26656

Synonym: X334,X-334,X 334,ARH 049020

Adropin (34-76) (human, mouse, rat)

Cat.No: T76664

Cat.No: T38715

Synonym: MSDC-0602K,Azemiglitazone potassium

Target: PPAR

Cat.No: T30579

Target: HDAC

GPR81 agonist 1

Cat.No: T62656

Target: GPR

Cat.No: T78169

Target: PDE

Nampt activator-2

Cat.No: T72617

Target: P450, NAMPT

AMPK activator 4

Cat.No: T62238

Target: AMPK

Cat.No: T27706

Synonym: BM170744,BM 170744,BM-170744,K111

Cat.No: T25780

Synonym: LMPTP-IN-23,LMPTP-IN 23,MDK4823,LMPTP-IN23,MDK 4823

Cat.No: T28511

Synonym: JTT-501,JTT501,PNU-182716,PNU182716,PNU-716

quercetin-3'-o-phosphate

Cat.No: T68132

Cat.No: T31732

Synonym: Evogliptin hydrochloride,DA 1229,DA1229,Evogliptin,DA-1229

Cat.No: T70141

CXCR2 antagonist 8

Cat.No: T60696

Amylin, amide, human

Cat.No: TP1183

Synonym: DAP amide, human

Amylin (8-37), human

Cat.No: T38764

Cat.No: T15043

Target: Others

Cat.No: T74716

Cat.No: T71251

Ganglioside GM3 Mixture (sodium salt)

Cat.No: T35588

Tyr0-Neurokinin A

Cat.No: T80915

Cat.No: T39490

Synonym: ZGN-1061,Aclimostat

Acetyl Gastric Inhibitory Peptide (human)

Cat.No: T76310

C20 Sphingomyelin (d18:1/20:0)

Cat.No: T35809

[D-Ala2]-GIP (human)

Cat.No: TP2019

Acetyl Gastric Inhibitory Peptide (human) TFA

Cat.No: T78543

Synonym: Human N-acetyl GIP TFA

11-Dehydrocorticosterone

Cat.No: T68808

MBX-8025 (sodium salt)

Cat.No: T35799

Cat.No: T72889

Glucocerebrosides (Gaucher's spleen)

Cat.No: T36582

Cat.No: T71981

Cat.No: T35634

Cat. No.	Product Name	Target	Signaling Pathways
T3881	Vaccarin	Integrin; Akt; PERK; AMPK	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Vaccarin 是从王不留行中提取的一种黄酮糖苷，可显著促进伤口愈合以及伤口部位的内皮和成纤维细胞增殖。它通过激活 AMPK 信号通路改善胰岛素抵抗和脂肪变性。
T6670	Silymarin Silybin B,水飞蓟素	SARS-CoV	Microbiology/Virology
	Silymarin (Silybin B) 是一种多酚类黄酮，是从水飞蓟或水飞蓟的种子中提取的一种 SARS-CoV-2 主蛋白酶抑制剂。它可降低肿瘤细胞的增殖，血管生成以及胰岛素抵抗，用于预防和治疗肝脏疾病，有潜力研究 COVID-19 。
T2869	Emodin Frangula emodin,大黄素	SARS-CoV; Casein Kinase; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Stem Cells
	Emodin (Frangula emodin) 是蒽醌衍生物，有抗SARS-CoV 作用。它阻断 SARS 冠状病毒刺突蛋白和血管紧张素转化酶 2 的相互作用。它抑制酪蛋白激酶 2 ，具有抗炎和抗癌作用。它可改善饮食诱导的肥胖小鼠的代谢紊乱。
TL0006	Cichoric Acid 菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid	Reactive Oxygen Species; HIV Protease	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
	Cichoric Acid (Dicaffeoyltartaric acid) 是一种天然化合物，具有抗氧化作用。
TN6339	(R)-5-Hydroxy-1,7-diphenylheptan-3-one (5R)-Dihydroyashabushiketol,(R)-5-羟基-1,7-二苯基-3-庚酮	Others	Others
	(R)-5-Hydroxy-1,7-diphenylheptan-3-one ((5R)-Dihydroyashabushiketol) 是从中药材高良姜的根茎中提取的。它抑制茶碱刺激的鼠 B16 黑色素瘤 4A5 细胞中的黑色素生成。
T4461	3,5-Diiodo-L-thyronine 3,5-二碘-L-甲状腺素,Diiodothyronine	Thyroid hormone receptor(THR); Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	3,5-Diiodo-L-thyronine (Diiodothyronine) 是内源性代谢产物的一种。
T4785	Oxfenicine 4-羟基-L-苯甘氨酸,4-Hydroxy-L-phenylglycine	Others	Others
	Oxfenicine (4-Hydroxy-L-phenylglycine) 是具有口服活性的肉碱棕榈酰转移酶-1 抑制剂。它在缺血期间保护心脏免受坏死组织的损害。它可抑制心脏中脂肪酸的氧化。
T4797	DEHP Bis(2-ethylhexyl) phthalate,邻苯二甲酸二(2-乙基己)酯	Others; Endogenous Metabolite	Metabolism; Others
	DEHP (Bis(2-ethylhexyl) phthalate) 是内源性代谢产物的一种。
T4S2128	Bilobetin 白果双黄酮,白果素	PKA; PPAR	DNA Damage/DNA Repair; Metabolism; Tyrosine Kinase/Adaptors
	Bilobetin 是银杏的活性成分，可改善胰岛素抵抗，增加肝脏对脂质的吸收和氧化，降低极低密度脂蛋白甘油三酯分泌和血液甘油三酯水平，增强组织中 β-氧化的酶的表达和活性，并减弱甘油三酯及其代谢产物的积累。它还增加了 PPARα的磷酸化，核转位和活性，并伴随着 cAMP 水平和 PKA 活性的升高。
T1273	Diacerein 双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein	IL Receptor; Interleukin	Immunology/Inflammation
	Diacerein (Fisiodar) 是一种慢效具有白介素-1β 抑制效果的蒽醌类化合物。
T6S0232	Eriodictyol 圣草酚,Huazhongilexone	Influenza Virus; DNA/RNA Synthesis; Nrf2; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Eriodictyol (Huazhongilexone) 是从中草药中得到的一种黄酮类天然产物，具有抗氧化、抗炎和抗糖尿病作用。它还是一种流感依赖 RNA 的RNA 聚合酶抑制剂，IC50为 18 nM。它可诱导Nrf2信号通路。
T3822	Bellidifolin Bellidifoline,龙胆山酮酚,Bellidifolium,雏菊叶龙胆酮	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Bellidifolin (Bellidifoline) 是从獐牙菜的茎中提取的一种呫吨酮，它能作为病毒蛋白 R 的抑制剂，具有保肝、降血糖、抗炎、抗氧化、抗肿瘤作用。
T2532	Tauroursodeoxycholate Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA	Apoptosis; ERK; P450; Caspase; Endogenous Metabolite	Apoptosis; MAPK; Metabolism; Proteases/Proteasome
	Tauroursodeoxycholate (UR 906)，又称 ursodoxicoltaurine，是一种高度亲水性的三级胆汁酸，在人体内以低浓度产生。Tauroursodeoxycholate 是 ursodeoxycholic acid 更亲水的形式，而 ursodeoxycholic acid 是人类体内自然产生的更丰富的胆汁酸。Tauroursodeoxycholate 正在研究用于几种疾病，如原发性胆汁性肝硬化(PBC)、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤滞和肌萎缩性侧索硬化症。
TN3511	Bi-linderone	Others	Others
	Bi-linderone shows significant activity against glucosamine-induced insulin resistance in HepG2 cells at a concentration of 1 microg/mL.
TL0014	Pinusolide	ERK; p38 MAPK; Calcium Channel; Lipoxygenase; PAFR; Caspase; JNK; AMPK	Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.
T36791	Lysophosphatidylcholine 18:2
	1-Linoleoyl-2-hydroxy-sn-glycero-3-PC (LGPC) is a lysophospholipid containing linoleic acid at thesn-1 position that has been found in mouse heart, lung, liver, spleen, kidney, plasma, and serum.1Serum levels of LGPC decrease with increasing insulin resistance and dysglycemia in humans.2 1.Okudaira, M., Inoue, A., Shuto, A., et al.Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MSJ. Lipid Res.55(10)2178-2192(2014) 2.Gall, ...
T83915	Norbixin hydrate
	Norbixin是一种在B. orellana中发现的类胡萝卜素，具有多样的生物活性。在无细胞测试中，它与过氧化物酶体增殖物激活受体γ (PPARγ)结合（Ki = 1.15 µM）。在心脑血管代谢综合征大鼠模型中，Norbixin (47.7 mg/kg) 能够减轻高血糖、高胰岛素血症和胰岛素抗性，降低血清脂质水平及心脏中硫代巴比妥酸反应性物质（TBARS）和谷胱甘肽（GSH）的水平。在胆固醇诱导的动脉粥样硬化兔模型中，它降低氧化型LDL和主动脉蛋白氧化水平，并减少动脉粥样硬化面积。Norbixin（每天0.1和1 mg/kg）减少汞诱导的大鼠肝细胞和白细胞DNA损伤。此外，它还能预防与年龄相关的黄斑变性（AMD）Abca4-/- Rdh8-/-小鼠模型中的光感受器退化。

天然产物

Cat.No: T3881

Target: Integrin, Akt, PERK, AMPK

Cat.No: T6670

Synonym: Silybin B,水飞蓟素

Target: SARS-CoV

Cat.No: T2869

Synonym: Frangula emodin,大黄素

Target: SARS-CoV, Casein Kinase, Autophagy

Cat.No: TL0006

Synonym: 菊苣酸,Dicaffeoyltartaric acid,Chicoric Acid

Target: Reactive Oxygen Species, HIV Protease

(R)-5-Hydroxy-1,7-diphenylheptan-3-one

Cat.No: TN6339

Synonym: (5R)-Dihydroyashabushiketol,(R)-5-羟基-1,7-二苯基-3-庚酮

Target: Others

3,5-Diiodo-L-thyronine

Cat.No: T4461

Synonym: 3,5-二碘-L-甲状腺素,Diiodothyronine

Target: Thyroid hormone receptor(THR), Endogenous Metabolite

Cat.No: T4785

Synonym: 4-羟基-L-苯甘氨酸,4-Hydroxy-L-phenylglycine

Target: Others

Cat.No: T4797

Synonym: Bis(2-ethylhexyl) phthalate,邻苯二甲酸二(2-乙基己)酯

Target: Others, Endogenous Metabolite

Cat.No: T4S2128

Synonym: 白果双黄酮,白果素

Target: PKA, PPAR

Cat.No: T1273

Synonym: 双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein

Target: IL Receptor, Interleukin

Cat.No: T6S0232

Synonym: 圣草酚,Huazhongilexone

Target: Influenza Virus, DNA/RNA Synthesis, Nrf2, Endogenous Metabolite

Cat.No: T3822

Synonym: Bellidifoline,龙胆山酮酚,Bellidifolium,雏菊叶龙胆酮

Target: Others, HIV Protease

Tauroursodeoxycholate

Cat.No: T2532

Synonym: Taurolite,牛磺熊去氧胆酸,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA

Target: Apoptosis, ERK, P450, Caspase, Endogenous Metabolite

Cat.No: TN3511

Target: Others

Cat.No: TL0014

Target: ERK, p38 MAPK, Calcium Channel, Lipoxygenase, PAFR, Caspase, JNK, AMPK

Lysophosphatidylcholine 18:2

Cat.No: T36791

Norbixin hydrate

Cat.No: T83915

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