56
2
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12165 |
nAChR agonist 1
DUN71755 |
AChR | Neuroscience |
nAChR agonist 1 (DUN71755) 是一种脑渗透性和口服有效的正变构 α7 烟碱乙酰胆碱受体 (α7 nAChR) 调节剂。它在 Ca2+中,对内源性表达 α7 nAChR 的人 IMR-32 神经母细胞瘤细胞的EC50为 0.32 μM。它可用于阿尔茨海默病的研究。 | |||
T14389 |
AZD 9272
|
GluR | Neuroscience |
AZD 9272 是一种脑渗透性的mGluR5 拮抗剂,可用于研究胃食管反流。 | |||
T9956 |
VK-28
|
Mitochondrial Metabolism; Lipid | Metabolism |
VK-28 是一种具有神经保护作用的脑渗透性铁螯合剂。 VK-28 抑制基础以及铁诱导的线粒体脂质过氧化。 | |||
T1741 |
AZD1080
|
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
AZD1080 是一种选择性GSK3抑制剂。它抑制重组人GSK3α和GSK3β,pKi(IC50) 分别为 8.2 (6.9 nM) 和 7.5 (31 nM)。 | |||
T22972 |
Methoxy-X04
|
Others | Others |
Methoxy-X04, a derivative of Congo red and Chrysamine-G, is a brain-permeable fluorescent probe for amyloid-β (Aβ). | |||
T6679 |
SRT 2104
SRT2104,sirtuin modulator,GSK2245840 |
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SRT 2104 (GSK2245840) 是一种高度选择性、可通过血脑屏障的 Sirt1激活剂,依赖于 NAD+,增加 Sirt1 蛋白水平,用于糖尿病和亨廷顿氏症的研究。 | |||
TQ0075 |
ML314
|
Neurotensin Receptor | GPCR/G Protein |
ML314 是一种具有脑渗透性非肽 β-抑制素偏向神经降压素 NTR1 受体激动剂(EC50:1.9 μM),是一种用于甲基苯丙胺滥用的偏向神经降压素受体配体,抑制 NTR2 和 GPR35。 | |||
T5490 |
AK-7
|
Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
AK-7 是一种大脑可渗透的 SIRT2 抑制剂,可在神经元模型中表征其降低胆固醇的特性,IC50 为 15.5 μM。 | |||
TQ0026 |
MDR-1339
DWK-1339 |
Beta Amyloid; Gamma-secretase | Neuroscience; Proteases/Proteasome; Stem Cells |
MDR-1339 是口服有效Aβ聚集抑制剂,可透过血脑屏障的。MDR-1339可用于阿尔兹海默症的研究。 | |||
TQ0238 |
Lanabecestat
LY3314814,AZD3293 |
BACE | Neuroscience |
Lanabecestat (AZD3293) 是一种具有高效性和高渗透性、口服活性且可穿过血脑屏障的 BACE1 抑制剂(Ki:0.4 nM),Lanabecestat 可用于研究像阿尔茨海默症类的神经系统疾病。 | |||
T10355 |
Apyramide
|
COX | Immunology/Inflammation; Neuroscience |
Apyramide 是一种抗炎试剂 (NSAID),是吲哚美辛的前药。Indomethacin 是一种强效的、血脑通透的、非选择性的 COX1 和 COX2 抑制剂。 | |||
T5468 |
YF-2
|
Others; Epigenetic Reader Domain; Histone Acetyltransferase | Chromatin/Epigenetic; Others |
YF-2 是一种高选择性,可透过血脑屏障的组蛋白乙酰转移酶激动剂,能够在海马区乙酰化 H3,对 CBP、PCAF 和 GCN5 的EC50值分别为 2.75、29.04 和 49.31 μM,具有抗肿瘤和抗阿尔滋海默症的活性。 | |||
T13298 |
Verubulin hydrochloride
MPC-6827 hydrochloride,N-(4-甲氧基苯基)-N,2-二甲基-4-喹唑啉胺盐酸盐 |
Microtubule Associated | Cytoskeletal Signaling |
Verubulin hydrochloride (MPC-6827 hydrochloride) 是一种血脑屏障渗透性微管破坏剂,具有强效和广谱的细胞毒活性,在人 MX-1 乳腺癌和其他小鼠异种移植癌模型中具有有效的抗癌活性。 | |||
T33514 |
MSC 2032964A
MSC-2032964A,MSC2032964A |
ASK | Apoptosis |
MSC 2032964A 是一种有效的选择性 ASK1 抑制剂 (IC50 = 93 nM),具有口服生物利用度和脑渗透性。它在小鼠 EAE 模型中抑制神经炎症,并在培养的小鼠星形胶质细胞中阻断 LPS 诱导的 ASK1 和 p38 磷酸化。 | |||
T73177 |
hCAII-IN-9
|
Carbonic Anhydrase | Metabolism |
hCAII-IN-9 是一种强效的碳酸酐酶抑制剂,对hCA II、hCA IX 和hCA XII 有抑制作用,IC50 分别为 1.18 μM 和 0.17 μM , and 2.99 μM 。hCAII-IN-9 没有血脑屏障透过性。 | |||
T8702 |
SKF-83566
|
Dopamine Receptor; 5-HT Receptor; AChR | GPCR/G Protein; Neuroscience |
SKF-83566 是一种具有血脑渗透性和口服活性的 D1 样多巴胺受体拮抗剂和一种较弱的竞争性 5-HT2 受体拮抗剂,Ki 为 11 nM。它是竞争性多巴胺转运蛋白抑制剂,可用于研究帕金森氏症和对尼古丁渴望的缓解的相关研究。 | |||
T72420 |
MTK458
EP-0035985 |
PTEN | PI3K/Akt/mTOR signaling |
MTK458 (EP-0035985) 是一种具有脑渗透性和口服活性的 PINK1 激活剂。MTK458 通过刺激 PINK1/TOM 复合物的二聚化和稳定来选择性地激活 PINK1MTK458 驱动α-突触核蛋白病理学的清除,可用于研究帕金森病。 | |||
T4494 |
CLOZAPINE N-OXIDE
氯氮平N-氧化,氯氮平N-氧化物 |
Dopamine Receptor; 5-HT Receptor; AChR; Drug Metabolite | GPCR/G Protein; Metabolism; Neuroscience |
Clozapine N-oxide 是 Clozapine 的主要代谢产物,具有血脑屏障渗透性。Clozapine N-oxide 是一种 DREADDs 激动剂,可激活 DREADD 受体 hM3Dq 和 hM4Di。Clozapine N-oxide 也是一种多巴胺拮抗剂和选择性毒蕈碱 M4 受体激动剂。 | |||
T4019 |
Cambinol
SIRT1/2 Inhibitor IV,NSC 112546 |
Apoptosis; Phospholipase; Sirtuin | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
Cambinol (SIRT1/2 Inhibitor IV) 是一种SIRT1和SIRT2的抑制剂,IC50值分别为 56 μM 和 59 μM。它是中性鞘磷脂酶的外泌体抑制剂。 | |||
T77341 |
GSK-3 inhibitor 4
|
GSK-3; CDK | Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells |
GSK-3 inhibitor 4 是一种具有口服活性和脑渗透性的 GSK-3,CDK2 和 CDK5 三重抑制剂,对 GSK-3β,GSK-3α,CDK2 和 CDK5 具有抑制作用,IC50 值分别为 0.56 nM ,0.45 nM ,0.47 μM,0.68 μM。GSK-3 inhibitor 4 可有效降低 Tau protein 水平。GSK-3 inhibitor 4 可用于研究阿尔茨海默症 。 | |||
T77342 |
GSK-3 inhibitor 3
|
GSK-3; Microtubule Associated | Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Stem Cells |
GSK-3 inhibitor 3 是一种具有选择性、具有口服活性和脑渗透性的 GSK-3 抑制剂,对 GSK-3α 和 GSK-3β 具有抑制作用, IC50s 分别为 0.35 nM 和 0.25 nM。GSK-3 inhibitor 3 在三重转基因小鼠阿尔茨海默病模型中降低 Tau 蛋白 (tau protein) S396 磷酸化水平,IC50为 10 nM。GSK-3 inhibitor 3 可用于研究神经系统疾病。 | |||
T13001 | SRT3657 | Sirtuin | Chromatin/Epigenetic; DNA Damage/DNA Repair |
SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect. | |||
T15407 |
GNE-0723
|
Others | Others |
GNE 0723 is an NMDAR brain permeable positive allosteric modulator (EC50: 21 nM for GluN2A; 7.4 and 6.2 μM for GluN2C and GluN2D, respectively). | |||
T15408 | GNE 5729 | Others | Others |
GNE 5729 is an NMDAR of brain permeable positive allosteric modulator (EC50: 37 nM for GluN2A; 4.7 and 9.5 μM for GluN2C and GluN2D, respectively). | |||
T14334 |
ASP2535
|
GlyT | Neuroscience |
ASP2535 is a potent, selective, orally bioavailable, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor.ASP2535 can improve cognitive impairment in animal models of schizophrenia and Alzheimer's disease[1]. | |||
T10688 |
Casopitant mesylate
GW679769B |
P450; Neurokinin receptor | GPCR/G Protein; Metabolism; Neuroscience |
Casopitant mesylate (GW679769B) is a selective, brain permeable, and orally active antagonist of neurokinin 1 (NK1) receptor. It is a second in the class of antiemetics. | |||
T41159 | NCT 501 hydrochloride | ||
NCT 501 hydrochloride is a potent and selective ALDH1A1 inhibitor (IC50 = 40 nM). Exhibits >1000-fold selectivity for ALDH1A1 over ALDH3A1, ALDH1B1, ALDH2, HPGD and HSD17β4. Also selective over a panel of 168 GPCRs. Blood-brain barrier permeable. | |||
T70807 |
Lanabecestat HCl
|
||
Lanabecestat, also known as AZD3293 and LY3314814, is a potent, highly permeable, orally active, blood-brain barrier (BBB) penetrating, BACE1 inhibitor with unique slow off-rate kinetics. AZD3293 displayed significant dose- and time-dependent reductions in plasma, cerebrospinal fluid, and brain concentrations of Aβ40, Aβ42, and sAβPPβ. | |||
T61644 | α-Synuclein inhibitor 6 | ||
α-Synuclein inhibitor 6 (compound 3ge) is a highly effective and blood-brain barrier-permeable inhibitor that targets the aggregation of α-Synuclein (α-Syn). It exhibits a potent inhibitory activity, with an IC50 value of 1.70 μM, leading to a remarkable inhibition ratio of 94.4% at 30 μM [1]. | |||
T40046 |
UGT8-IN-1
UGT8-IN-1 |
||
UGT8-IN-1 is a brain-permeable and orally-active inhibitor that specifically targets the ceramide galactosyltransferase enzyme (UGT8). By inhibiting UGT8, this compound has the potential to be employed in research pertaining to lysosomal storage disorders. | |||
T11185 |
EML741
|
Histone Methyltransferase | Chromatin/Epigenetic |
EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated. EML741 is a histone lysine methyltransferase G9a/GLP inhibitor, with an IC50 of 23 nM, Kd of 1.13 μM for G9a. | |||
T69608 |
TG11-77 HCl
|
||
TG11-77 HCl is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 HCl has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 HCl are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties. | |||
T62142 |
COX-2-IN-17
|
||
COX-2-IN-17 是一种有效的、具有血脑屏障通透性的 COX-2(环氧化酶 -2) 抑制剂 (IC50: 0.02 μM),具有抗炎和镇痛活性。 | |||
T69609 |
TG11-77 free base
|
||
TG11-77 free base is a novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist. TG11-77 free base has a Schild KB of 9.7 nM on EP2, a water solubility of 2.5 mM, a brain-to-plasma ratio of 0.4, and a plasma half-life of 2.4 h in mice. TG11-77 free base are representative second generation EP2 antagonists with improved pharmacodynamic and pharmacokinetic properties. | |||
T35563 |
PF-5274857 hydrochloride
|
||
PF-5274857 hydrochloride 是有效的、具有口服活性的、选择性的、可透过血脑屏障的 Smo 拮抗剂,其 IC50=5.8 nM,Ki=4.6 nM。它有用于包括激活的 Hh 途径驱动的脑肿瘤和脑转移在内的多种肿瘤的研究潜力。 | |||
T79253 |
HAT-IN-8
|
Parasite | Microbiology/Virology |
HAT-IN-8(Compound 38)是一款能穿透血脑屏障的T. brucei抑制剂(EC50:0.18 μM),适用于研究人类非洲锥虫病。 | |||
T61611 |
α-Synuclein inhibitor 4
|
||
α-Synuclein inhibitor 4 (compound 3gh) is a highly effective and blood-brain barrier-permeable inhibitor of α-Synuclein aggregation. It displays potent activity, with an IC50 value of 0.98 μM, and exhibits a remarkable inhibition ratio of 91.2% at a concentration of 30 μM [1]. | |||
T78969 | PB131 | HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
PB131为选择性HDAC6抑制剂,能穿透血脑屏障且显示出高结合亲和性(IC50: 1.8 nM)。该化合物展现出显著的抗炎活性,适用于炎症特别是神经炎症的研究领域。 | |||
T62202 |
mGluR2 modulator 1
|
||
mGluR2 modulator 1 (compound 95) 是一种有效的、具有血脑屏障通透性的 mGluR2 (代谢型谷氨酸受体-2)正向变构调节剂 (EC50: 0.03 μM)。mGluR2 modulator 1 能够用于研究精神病。 | |||
T37577 |
Glycogen Phosphorylase Inhibitor
|
||
Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM). It blocks glucagon-induced hepatic glycogenolysis in vivo. Glycogen phosphorylase inhibitor has been used to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells. | |||
T41143 |
pCPA methyl ester hydrochloride
4-氯-DL-苯基丙氨酸甲酯盐酸盐,4-Chloro-DL-phenylalanine methyl ester hydrochloride |
5-HT Receptor; Hydroxylase | GPCR/G Protein; Metabolism; Neuroscience |
pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) 是色氨酸羟化酶抑制剂和5-HT 合成的抑制剂。 pCPA methyl ester hydrochloride 可穿过血脑屏障并降低 5-HT 中枢可用性。 | |||
T62674 | LSD1-IN-21 | ||
LSD1-IN-21 是一种有效的、具有血脑屏障通透性的 LSD1 (赖氨酸特异性去甲基化酶-1) 抑制剂 (IC50: 0.956 μM)。LSD1-IN-21 能够明显减少促炎细胞因子 TNF-α,表现出良好的抗癌和抗炎效果。 | |||
T62898 |
Glucosylceramide synthase-IN-1
|
||
Glucosylceramide synthase-IN-1 (T-036) 是一种有效的、口服具有活力的、具有血脑屏障通透性的 glucosylceramide synthase (GCS) 抑制剂,作用于人 GCS (IC50: 31 nM) 和小鼠 GCS (IC50: 51 nM)。Glucosylceramide synthase-IN-1 能够用于研究戈谢病。 | |||
T74781 |
UT-11
|
||
UT-11是一种有效且具有脑渗透性的mPGES-1抑制剂,能够降低人类(SK-N-AS)和小鼠(BV2)细胞内PGE2的生成,其IC50s分别是0.10 μM和2.00 μM。 | |||
T69632 |
VRT-043198
|
||
VRT-043198 是 VX-765 (Belnacasan) 的活性代谢物,是有效的、选择性的、能透过血脑屏障的caspase-1的抑制剂。VRT-043198 对caspase-1和 caspase-4 的 Ki 值分别为 0.8 nM 和 0.6 nM。 | |||
T83469 | 10m/ZS44 | ||
10m/ZS44是一种能够穿透血脑屏障的Glioblastoma (GBM) 抑制剂,在小鼠异种移植模型中有效抑制了GBM肿瘤生长,并通过激活SIRT1/p53介导的细胞凋亡途径来抑制U251细胞增殖。 | |||
T62062 | MAO-B-IN-7 | ||
MAO-B-IN-7 是有效的、具有血脑屏障渗透性的MAO-B 和AChE 抑制剂。MAO-B-IN-7抑制人 AChE、电鳗 AChE 和 MAO-B 的IC50分别为 41 nM、87 nM 和 0.3 μM。MAO-B-IN-7 可以有效缓解氧化应激和神经炎症损伤。 | |||
T62578 | BuChE-IN-1 | ||
BuChE-IN-1 (Compound 23) 是一种丁酰胆碱酯酶 (BuChE) 的有效抑制剂。其中丁酰胆碱酯酶 (BuChE) 被认为是进展性阿尔茨海默病 (AD) 的生物标志物。BuChE-IN-1 具有低细胞毒性和高血脑屏障 (BBB) 渗透性。BuChE-IN-1 是一种具有潜力能够用于研究 AD 的 BuChE 抑制剂。 | |||
T78603 |
Sotuletinib dihydrochloride
BLZ945 dihydrochloride |
c-Fms | Tyrosine Kinase/Adaptors |
Sotuletinib (BLZ945) dihydrochloride 是一种CSF1-R特异性抑制剂,具有口服活性和血脑屏障透过性 (IC50=1 nM)。它能诱导肿瘤细胞凋亡,并在小鼠模型中有效抑制肿瘤生长,适用于癌症和肌萎缩侧索硬化症 (ALS) 研究。 | |||
T62664 | Glucosylceramide synthase-IN-2 | ||
Glucosylceramide synthase-IN-2 (compound T-690) 是一种有效的、具有血脑屏障通透性的、口服具有活力的 glucosylceramide synthase (GCS) 抑制剂,作用于人 GCS (IC50: 15 nM) 和小鼠 GCS (IC50: 190 nM)。Glucosylceramide synthase-IN-2 能够非竞争性抑制 C8 神经酰胺和 UDP 葡萄糖。Glucosylceramide synthase-IN-2 能够用于研究戈谢病。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T16012 |
Marizomib
NPI-0052,Salinosporamide A,ML858 |
Proteasome | Proteases/Proteasome; Ubiquitination |
Marizomib (ML858) 是一种新型不可逆的脑渗透性泛蛋白酶体 (proteasome) 抑制剂,对 20S 蛋白酶体的 CT-L (β5)、CT-T-laspase 样 (C-L, β1) 和胰蛋白酶样 (T-L, β2) 具有抑制作用, IC50 分别为 3.5, 28, 430 nM。 | |||
T13493 | 3-Acetyldeoxynivalenol | Others | Others |
3-Acetyldeoxynivalenol is a trichothecene mycotoxin deoxynivalenol acetylated derivative and a blood-brain barrier (BBB) permeable mycotoxin. |