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93

抑制剂 & 化合物

27

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14007	PAF-AN-1	PAFR	GPCR/G Protein
	PAF-AN-1是一种新型有效的血小板激活因子受体 (PAF) 拮抗剂，参与研究过敏性死亡。
T21547	PAF (C16) C16-PAF	ERK; MEK; MAPK; Endogenous Metabolite	MAPK; Metabolism
	PAF (C16) 是有效的 MAPK 和 MEK/ERK 激活剂，可诱导血管通透性增加。PAF (C16) (PAF (C16)) 是血小板活化因子，是一种磷脂衍生介质，也是 PAF G 蛋白偶联受体 (PAFR) 的配体。PAF (C16) 在体外实验中显示出抗凋亡和抗炎活性，通过与其受体（PAF-R）相互作用以执行细胞信号传导来抑制 caspase 依赖性凋亡。
T36180	Azelaoyl PAF
	Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which promote the differentiation of monocytes via the nuclear receptor PPARγ. One of these substances was recently isolated and purified from oxLDL, and identified as azelaoyl PAF. Azelaoyl PAF is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF is more potent than 15-deoxy-δ12,14-prostaglandin J2, and equipotent with rosiglitazone as a ligand for this receptor.
T36763	PAF C-18
	PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling" and 'de novo' pathways. It is less potent than PAF C-16 in the induction of platelet aggregation
T36764	PAF C-18:1
	PAF C-18:1 is a naturally occurring phospholipid produced by cells upon stimulation and plays a role in the establishment and maintenance of the inflammatory response. It is less potent than PAF C-16 and PAF C-18 in the induction of neutrophil chemotaxis, but is equipotent to PAF C-16 and PAF C-18 in promoting eosinophil migration. PAF C-18:1 activates the PAF receptor and has been used in antibody binding experiments to determine the importance of an acyl linkage at the sn-2 position for recogn...
T36205	Methylcarbamyl PAF C-16
	Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH. It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma. In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc and c-fos and the activation of mitogen-activated protein kinase. Methy...
T37268	PAF C-16 Carboxylic Acid
	PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling" and 'de novo' pathways. It is a potent mediator of neutrophil migration and the production of reactive oxygen species and IL-6. Pathological processes involving PAF include necrotizing enterocolitis
T19104	2-Thio-PAF	Others	Others
	2-Thio-PAF is a synthetic analog of PAF used in a colorimetric assay for PAF acetylhydrolase.
T29308	Lyso-PAF C-16
	Lyso-PAF C-16 is a biologically inactive precursor of platelet activating factor.
T6242	Rupatadine Fumarate 富马酸卢帕他定,Rinialer,Rupafin,Alergoliber	PAFR; Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Rupatadine Fumarate (Rinialer) 是一种可口服的长效PAF/H1受体的双抑制剂，Ki 值分别为 0.55 μM 和 0.1 μM。它可研究过敏性鼻炎和荨麻疹。
T80312	PAF26
	PAF26为针对植物病原真菌Penicillium digitatum、Penicillium italicum及Botrytis cinerea具有活性的抗菌肽。
T15338	Foropafant SR27417,福罗帕泛	Others; Platelet aggregation	Others
	Foropafant (SR27417) 是一种高效和特异性的血小板活化因子 (PAF) 受体拮抗剂 (Ki: 57 pM)。 Foropafant 有效抑制 PAF 诱导的兔和人血小板聚集。
T28607	Rocepafant LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730	Platelet aggregation	Others
	Rocepafant (LAU8080) 是一种血小板活化因子(PAF)拮抗剂，可减轻新生大鼠缺氧缺血性脑损伤。Rocepafant 抑制肿瘤坏死因子-Afa 介导的小鼠 L929 肿瘤细胞的细胞毒性。
T17178	Tulopafant RP 59227	PAFR	GPCR/G Protein
	Tulopafant（RP 59227）是一种有效的血小板活化因子 (PAF) 拮抗剂，可增加毛细血管通畅性并延长异体心脏移植的生存期。
T68124	Pafenolol	Adrenergic Receptor; P-gp	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Pafenolol 是一种 P-糖蛋白调节剂，Ki 值为5.5 µM。Pafenolol 是一种可口服的且具有选择性的β肾上腺素受体拮抗剂。
T0866	Propafenone Rythmol,普罗帕酮,Propafenonum	Potassium Channel; MRP; Sodium Channel	Immunology/Inflammation; Membrane transporter/Ion channel
	Propafenone (Propafenonum) 是钠通道阻滞剂，它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ，具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡，从而抑制食管癌增殖。
T1280	Nepafenac AL 6515,AHR 9434,奈帕芬胺	COX	Immunology/Inflammation; Neuroscience
	Nepafenac (AHR 9434) 是一种非甾体抗炎药，可抑制COX-2，是Amfenac 的原药。
T9445	Vepafestinib	c-RET	Apoptosis; Tyrosine Kinase/Adaptors
	Vepafestinib 是 RET 的抑制剂，具有潜在的抗癌活性。
T6955	Propafenone hydrochloride Propafenone HCl,Arythmol,SA-79 (hydrochloride),Rytmonorm,盐酸普罗帕酮,Rythmol	Sodium Channel	Membrane transporter/Ion channel
	Propafenone hydrochloride (Arythmol8) 具有抗心律不齐的功效，可用于心房和心室性心律不齐。
T14300	Apafant WEB 2086,阿帕泛	Others	Others
	Apafant is a potent antagonist of platelet-activating factor (PAF), inhibits PAF binding to human PAF receptors(Ki : 9.9 nM).
T33466	Modipafant
	Modipaafant is a potent dihydropyridine PAF (platelet activating factor) antagonist.
T28081	(Rac)-Modipafant UK-74505,Modipafant racemate,UK74505,UK 74505
	Modipafant racemate is a potent and specific oral platelet activating factor (PAF) receptor antagonist.
T27821	Lexipafant ISV-611,GR-167089,DO-6,BB-882,DO6,BB882
	Lexipafant is a platelet-activating factor (PAF) receptor antagonist.
T27638	Israpafant Y-24180,Y 24180,Y24180
	Israpafant is a selective antagonist for the platelet-activating factor receptor ( IC50 = 0.84nM). Israpafant inhibits PAF-induced human platelet aggregation. Israpafant inhibits the activation of eosinophil cells and consequently delays the development o
T26775	Bepafant WEB-2170,WEB2170,STY 2108,STY-2108,WEB 2170
	Bepafant is a platelet activating factor (PAF) antagonist. Bepafant may produce significant anti-inflammatory effects. Bepafant triggered apoptosis in NB4, KG1, and NB4-MR4 cells where PTEN was expressed, but not in THP1 and U937 cells where PTEN was abse
T12548	Propafenone D7 hydrochloride 盐酸普罗帕酮 D7,SA-79 (D7 hydrochloride)	Others	Others
	Propafenone D7 hydrochloride is the deuterium labeled Propafenone, and is a classic anti-arrhythmic medication.
T16874	Setipafant BN-50727,司替帕泛,LAU-0901	Others	Others
	Setipafant is an antagonist of the platelet-activating factor.
T39103	Pafolacianine OTL 38
	Pafolacianine (OTL 38) is a near-infrared dye-based fluorescent marker utilized for identifying ovarian cancer lesions during surgeries.
T81111	SPPHPSPAFSPAFDNLYYWDQ TFA
	SPPHPSPAFSPAFDNLYYWDQ TFA，一种II类大鼠HER2/neu多表位肽，应用于II类HER2-DC1疫苗的研究。
T81112	SPPHPSPAFSPAFDNLYYWDQ
	SPPHPSPAFSPAFDNLYYWDQ 为多表位 II 类大鼠HER2/neu 肽，适用于 HER2-DC1 II 类疫苗研究。
T81270	Ripafollitropin alfa (bovine)
	Ripafollitropin alfa (bovine)为一种结合了重组促卵泡激素(FSH)与绒毛膜促性腺激素(HCG)的融合蛋白。
T19153	5-Hydroxy Propafenone D5 Hydrochloride GPV-129 D5 Hydrochloride	Others	Others
	5-Hydroxy Propafenone D5 HCl is the deuterium labeled 5-Hydroxy Propafenone.
T70999	Aspafilioside B
	Aspafilioside B is a steroidal saponin extracted from Asparagus filicinus that inhibits the growth and proliferation of HCC cell lines.
T12811	(S)-Propafenone (S)-SA-79	Others	Others
	(S)-Propafenone ((S)-SA-79) is the S-enantiomer of Propafenone. It possesses beta-blocking properties and exhibits class 1 antiarrhythmic activity reliant on sodium channel blockade.
T31996	Grepafloxacin Hydrochloride DSSTox_CID_26692,OPC-17116,DSSTox_RID_81826,DSSTox_GSID_46692
	Grepafloxacin Hydrochloride is an antimicrobial agent, oral broad-spectrum fluoroquinolone. It is used to treat bacterial infections.
T23951	Dacopafant UNII-H1T03Z1G60
	Dacopafant is an antagonist of platlet activationg factor receptor.
T24587	Pafuramidine maleate DB-289,DB289,DB 289
	Pafuramidine is an orally bioavailable prodrug of formamidine which was developed for the treatment of human African trypanosomiasis.
T20840	Apaflurane FM200,FM-200,FM 200
	Apaflurane is a chemical fire extinguishing agent.
T12208	Nepafenac-d5 奈帕芬胺 D5,AHR-9434 D5,AL-6515 D5	Others	Others
	Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective inhibitor of COX-2 .
T16428	Pafuramidine DB289	Others	Others
	Pafuramidine is an orally bioavailable prodrug of furamidine. It has activity against Pneumocystis pneumonia (IC50 value: 4.5 nM)
T38586	Grepafloxacin dl-Grepafloxacin,OPC-17116
	Grepafloxacin (OPC-17116) is a fluoroquinolone antibiotic that is administered orally. It possesses strong efficacy against community-acquired respiratory pathogens, notably Streptococcus pneumonia. Grepafloxacin exhibits excellent tissue penetration and demonstrates a promising pharmacodynamic profile.
T25461	Grepafloxacin, (S)- L-Grepafloxacin
	Grepafloxacin, (S)- is an oral broad-spectrum fluoroquinolone antibacterial used for the treatment of bacterial infections.
T77039	Ipafricept
	Ipafricept (OMP-54F28; FZD8-Fc) 是一类重组融合蛋白，由人卷曲 8 受体胞外部分融合到结合Wnt 配体的人IgG1Fc 片段组成。Ipafricept 具有实体瘤抑制活性，耐受性良好。
T24586	PAFAH1b2 PAFAH-1-b-2,3-IN-P11,3INP11,3 IN P11,PAFAH 1 b 2
	PAFAH1b2 is a selective platelet-activating factor acetylhydrolases 1b2 and 1b3 inhibitor that acts by impairing cancer cell survival.
T68101	minopafant
	minopafant 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T68101，CAS号为 790174-16-2。
T19686	SCH-37370 乙酰地氯雷他定	Platelet aggregation	Others
	SCH-37370 是一种有效且具有口服活性的血小板活化因子和组胺双重拮抗剂。 Sch 37370 阻断 [3H]pyrilamine 与大鼠脑膜中组胺-H1 受体的结合。 Sch 37370 选择性地抑制 PAF 诱导的人血小板聚集（IC50：0.6 mM），并且还与 PAF 竞争与人肺膜制剂中特定位点的结合（IC50：1.2 mM）。
T27159	DF-1111301 DF1111301,DF 1111301	Platelet aggregation; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience; Others
	DF-1111301 是一种具有抗组胺 H1和抗PAF活性的新型抗过敏化合物。
T27102	CV-6209
	CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor.
T4511	ST271 ST 271	Phospholipase; Tyrosine Kinases	Metabolism; Tyrosine Kinase/Adaptors
	ST271 是蛋白质酪氨酸激酶 (PTK) 抑制剂，抑制 fMet-Leu-Phe 和 PAF 引起的 phospholipase D 活化的IC50值分别为 6.7 和 9 μM。
T10844	CMI-392	Others	Others
	CMI-392 is a dual 5-lipoxygenase inhibitor and platelet-activating factor (PAF) receptor antagonist (IC50s: 100 and 10 nM).

化合物

Cat.No: T14007

Target: PAFR

Cat.No: T21547

Synonym: C16-PAF

Target: ERK, MEK, MAPK, Endogenous Metabolite

Cat.No: T36180

Cat.No: T36763

Cat.No: T36764

Methylcarbamyl PAF C-16

Cat.No: T36205

PAF C-16 Carboxylic Acid

Cat.No: T37268

Cat.No: T19104

Target: Others

Lyso-PAF C-16

Cat.No: T29308

Rupatadine Fumarate

Cat.No: T6242

Synonym: 富马酸卢帕他定,Rinialer,Rupafin,Alergoliber

Target: PAFR, Autophagy, Histamine Receptor

Cat.No: T80312

Cat.No: T15338

Synonym: SR27417,福罗帕泛

Target: Others, Platelet aggregation

Cat.No: T28607

Synonym: LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730

Target: Platelet aggregation

Cat.No: T17178

Synonym: RP 59227

Target: PAFR

Cat.No: T68124

Target: Adrenergic Receptor, P-gp

Cat.No: T0866

Synonym: Rythmol,普罗帕酮,Propafenonum

Target: Potassium Channel, MRP, Sodium Channel

Cat.No: T1280

Synonym: AL 6515,AHR 9434,奈帕芬胺

Target: COX

Cat.No: T9445

Target: c-RET

Propafenone hydrochloride

Cat.No: T6955

Synonym: Propafenone HCl,Arythmol,SA-79 (hydrochloride),Rytmonorm,盐酸普罗帕酮,Rythmol

Target: Sodium Channel

Cat.No: T14300

Synonym: WEB 2086,阿帕泛

Target: Others

Cat.No: T33466

(Rac)-Modipafant

Cat.No: T28081

Synonym: UK-74505,Modipafant racemate,UK74505,UK 74505

Cat.No: T27821

Synonym: ISV-611,GR-167089,DO-6,BB-882,DO6,BB882

Cat.No: T27638

Synonym: Y-24180,Y 24180,Y24180

Cat.No: T26775

Synonym: WEB-2170,WEB2170,STY 2108,STY-2108,WEB 2170

Propafenone D7 hydrochloride

Cat.No: T12548

Synonym: 盐酸普罗帕酮 D7,SA-79 (D7 hydrochloride)

Target: Others

Cat.No: T16874

Synonym: BN-50727,司替帕泛,LAU-0901

Target: Others

Pafolacianine

Cat.No: T39103

Synonym: OTL 38

SPPHPSPAFSPAFDNLYYWDQ TFA

Cat.No: T81111

SPPHPSPAFSPAFDNLYYWDQ

Cat.No: T81112

Ripafollitropin alfa (bovine)

Cat.No: T81270

5-Hydroxy Propafenone D5 Hydrochloride

Cat.No: T19153

Synonym: GPV-129 D5 Hydrochloride

Target: Others

Aspafilioside B

Cat.No: T70999

(S)-Propafenone

Cat.No: T12811

Synonym: (S)-SA-79

Target: Others

Grepafloxacin Hydrochloride

Cat.No: T31996

Synonym: DSSTox_CID_26692,OPC-17116,DSSTox_RID_81826,DSSTox_GSID_46692

Cat.No: T23951

Synonym: UNII-H1T03Z1G60

Pafuramidine maleate

Cat.No: T24587

Synonym: DB-289,DB289,DB 289

Cat.No: T20840

Synonym: FM200,FM-200,FM 200

Cat.No: T12208

Synonym: 奈帕芬胺 D5,AHR-9434 D5,AL-6515 D5

Target: Others

Cat.No: T16428

Synonym: DB289

Target: Others

Cat.No: T38586

Synonym: dl-Grepafloxacin,OPC-17116

Grepafloxacin, (S)-

Cat.No: T25461

Synonym: L-Grepafloxacin

Cat.No: T77039

Cat.No: T24586

Synonym: PAFAH-1-b-2,3-IN-P11,3INP11,3 IN P11,PAFAH 1 b 2

Cat.No: T68101

Cat.No: T19686

Synonym: 乙酰地氯雷他定

Target: Platelet aggregation

Cat.No: T27159

Synonym: DF1111301,DF 1111301

Target: Platelet aggregation, Histamine Receptor

Cat.No: T27102

Cat.No: T4511

Synonym: ST 271

Target: Phospholipase, Tyrosine Kinases

Cat.No: T10844

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN4222	Homoeriodictyol 7-O-β-D-glucoside 高圣草素-7-O-Β-D-葡萄糖苷,Homoeriodictyol 7-O-glucoside	Others; Platelet aggregation	Others
	Homoeriodictyol 7-O-β-D-glucoside (Homoeriodictyol 7-O-glucoside) 是 Viscum coloratum(Kom.)Nakai 的天然产物。Homoeriodictyol 7-O-β-D-glucoside 是血小板活化因子 (PAF) 的拮抗剂。
T30170	Aspafilioside A
	Aspafilioside A is a steroidal saponin isolated from the root of Asparagus filicinus.
TN1170	1-Cinnamoylpyrrolidine	Platelet aggregation	Others
	1-Cinnamoylpyrrolidine 是从 Piper caninum 制备的天然产物，可作为一种 DNA 链断裂剂，在Cu2+ 存在下诱导质粒 pBR322 DNA 超螺旋的松弛。1-Cinnamoylpyrrolidine 对 PAF 诱导的血小板聚集有抑制作用，IC50 值为 37.3 μM。
TN2322	Yangambin	Calcium Channel; PAFR	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism
	Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素，是选择性PAF 受体拮抗剂，通过调控Ca2+通道抑制 Ca2+流入，导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少，具有降压作用。
T2749	Ginkgolide A 银杏内酯A,BN-52020	GABA Receptor; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism; Neuroscience
	Ginkgolide A (BN-52020) 是从银杏叶提取出来的一种天然产物，是 GABA 拮抗剂，有用于多种炎症和免疫疾病的研究潜力。
T7030	anemarsaponin B 知母皂苷B,知母皂苷 B	p38 MAPK; NF-κB; MEK; COX; NO Synthase	Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Anemarsaponin B 是一种甾体皂苷，可降低iNOS 和COX-2的蛋白和 mRNA 水平，减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-κB 的 p65 亚基的核转位，还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。
TN3161	6-Deoxyjacareubin	Antioxidant; PAFR; Platelet aggregation; Antifection	GPCR/G Protein; Microbiology/Virology; Others; oxidation-reduction
	6-Deoxyjacareubin 具有有效的抗氧化和抗真菌活性。 6-Deoxyjacareubin 抑制血小板活化因子 (PAF) 受体，IC50 为 29.0 microM，可用于天然 PAF 受体拮抗剂的研究。
TN4795	Piperenone	PAFR	GPCR/G Protein
	Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist.
TN3520	Bisdethiobis(methylthio)gliotoxin	PAFR	GPCR/G Protein
	Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist.
TN2763	2-Hydroxy-3-methoxybenzoic acid glucose ester	PAFR	GPCR/G Protein
	2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF-induced death at a dose of 300 micrograms/mouse.
TN4181	Hancinone C	PAFR	GPCR/G Protein
	Hancinone C shows inhibitory activity against the platelet aggregation caused by PAF.
TN5045	Spiradine F	PAFR	GPCR/G Protein
	Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner.
TN4821	Pregomisin	PAFR	GPCR/G Protein
	Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M.
TN4794	Pinusolidic acid	PAFR	GPCR/G Protein
	Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 micrograms/ml).
T68233	Kadsurenone
	Kadsurenone is a platelet-activating factor receptor antagonist from Chinese herbal plant, haifenteng. It is a useful and promising treatment strategy for breast cancer bone metastases by blocking the PAF/PTAFR signaling pathway.
TN6056	Zanthobungeanine 8-Methoxy-N-methylflindersine
	Zanthobungeanine has anti-inflammatory activity, it shows moderate NO production inhibitory activity with an IC50 value of 37.26 mg /L.It shows obviously inhibitoryactivity to platelet aggregation caused by platelet-activating factor (PAF). Zanthobungeani
T83460	11-O-β-D-glucopyranosyl thamnosmonin
	11-O-β-D-glucopyranosyl thamnosmonin是一种香豆素苷，能够从Angelica apaensis根部提取。该化合物对PAF、AA和ADP诱发的兔血小板聚集表现出轻度的抑制效果。
TN1815	Kadsulignan L	HBV; PAFR	GPCR/G Protein; Microbiology/Virology
	Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC50 value of 2.6 x 10(-5) M.
T79948	Kadsurenin B
	Kadsurenin B为PAF（platelet-activating factor）拮抗剂，展现出神经保护作用。该化合物在药理学领域显示出广泛的研究潜力，包括抗菌、抗炎、神经保护、抗氧化、抗血小板聚集、细胞毒性和抗寄生虫等效能。
T13716	(+)-Guaiacin	Others	Others
	(+)-Guaiacin is a compound isolated from the bark of Machilus wangchiana Chun. It shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF).
TN5414	Wallichinine
	Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significa
TN3723	Cryptomeridiol	PAFR; Antifection	GPCR/G Protein; Microbiology/Virology
	Cryptomeridiol is a potential skin-whitening agent, exhibits melanogenesis inhibitory activity on α-MSH-stimulated B16 melanoma cells. Cryptomeridiol has low activity against A. niger, T. mentagrophytes, and C. albicans. (-)-Cryptomeridiol also exhibits a significant and concentration-dependent inhibitory effect on PAF receptor binding, with inhibitory concentration (IC)(50) values of 17.5 uM.
TN4088	Futoenone	PAFR	GPCR/G Protein
	Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2' site of the enzymes. Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both platelet activating factor receptor(PAF)and 5-lipoxygenase antagonist activity.
T38015	Herquline A
	Herquline A is an alkaloid fungal metabolite originally isolated from P. herquei. It inhibits cell death induced by influenza A strain A/PR/8/34 in MDCK cells with an IC50 value of 10 μg/ml and inhibits viral replication in a plaque assay in a concentration-dependent manner. Herquline A also inhibits platelet aggregation induced by ADP and platelet-activating factor (PAF) in vitro (IC50s = 180 and 240 μM, respectively).
TL0014	Pinusolide	ERK; p38 MAPK; Calcium Channel; Lipoxygenase; PAFR; Caspase; JNK; AMPK	Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.
TN4664	Norarmepavine	Others	Others
	N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)- N-norarmepavine exhibits significa
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...

天然产物

Homoeriodictyol 7-O-β-D-glucoside

Cat.No: TN4222

Synonym: 高圣草素-7-O-Β-D-葡萄糖苷,Homoeriodictyol 7-O-glucoside

Target: Others, Platelet aggregation

Aspafilioside A

Cat.No: T30170

1-Cinnamoylpyrrolidine

Cat.No: TN1170

Target: Platelet aggregation

Cat.No: TN2322

Target: Calcium Channel, PAFR

Cat.No: T2749

Synonym: 银杏内酯A,BN-52020

Target: GABA Receptor, Endogenous Metabolite

anemarsaponin B

Cat.No: T7030

Synonym: 知母皂苷B,知母皂苷 B

Target: p38 MAPK, NF-κB, MEK, COX, NO Synthase

6-Deoxyjacareubin

Cat.No: TN3161

Target: Antioxidant, PAFR, Platelet aggregation, Antifection

Cat.No: TN4795

Target: PAFR

Bisdethiobis(methylthio)gliotoxin

Cat.No: TN3520

Target: PAFR

2-Hydroxy-3-methoxybenzoic acid glucose ester

Cat.No: TN2763

Target: PAFR

Cat.No: TN4181

Target: PAFR

Cat.No: TN5045

Target: PAFR

Cat.No: TN4821

Target: PAFR

Pinusolidic acid

Cat.No: TN4794

Target: PAFR

Cat.No: T68233

Zanthobungeanine

Cat.No: TN6056

Synonym: 8-Methoxy-N-methylflindersine

11-O-β-D-glucopyranosyl thamnosmonin

Cat.No: T83460

Cat.No: TN1815

Target: HBV, PAFR

Cat.No: T79948

Cat.No: T13716

Target: Others

Cat.No: TN5414

Cat.No: TN3723

Target: PAFR, Antifection

Cat.No: TN4088

Target: PAFR

Cat.No: T38015

Cat.No: TL0014

Target: ERK, p38 MAPK, Calcium Channel, Lipoxygenase, PAFR, Caspase, JNK, AMPK

Cat.No: TN4664

Target: Others

Cat.No: T38330

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